C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 16/22 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des facteurs de croissance
The invention relates to proteins having multi-specific binding abilities by fusion of an OB-fold variant, in particular from the Sac7d family, to the light or heavy chain of an antibody.
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
3.
ANTI-FACTOR C3 SAC7D VARIANTS AND THEIR MEDICAL USE FOR TREATING COMPLEMENT-MEDIATED DISORDERS
The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the complement component 3 (C3) and/or the component C3b obtained after hydrolysis of C3, and inhibits the complement cascade.
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 38/00 - Préparations médicinales contenant des peptides
4.
COMPOUNDS AND METHODS FOR EXTENDING HALF LIFE OF BIOMOLECULES
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind to human and mouse serum albumin and that can be used to increase serum half-life of elements associated therewith.
The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the human leptin receptor and is able to trigger the crossing of the intestinal barrier, in particular of biologicals associated with it.
The invention relates to variants of OB-fold proteins, hi particular of the Sac7d family that bind PD-L1 or HSP110 and are able to be used alone or in combination for cancer treatment.
C07K 14/31 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Micrococcaceae (F) provenant de Staphylococcus (G)
The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the complement component 3 (C3) and/or the component C3b obtained after hydrolysis of C3, and inhibits the complement cascade.
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
9.
COMPOUNDS AND METHODS FOR EXTENDING HALF LIFE OF BIOMOLECULES
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind to human and mouse serum albumin and that can be used to increase serum half-life of elements associated therewith.
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that are able to bind a subunit of a multimeric protein and inhibit the formation of the multimer.
C07K 14/44 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de protozoaires
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind PD-L1 or HSP110 and are able to be used alone or in combination for cancer treatment.
The invention relates to proteins having multi-specific binding abilities by fusion of an OB-fold variant, in particular from the Sac7d family, to the light or heavy chain of an antibody.
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical products for use in industry and science; chemical
reagents (other than for medical or veterinary use);
chemical diagnostic reagents for industrial use; chemical
substances intended for separation (other than for medical
or veterinary purposes). Pharmaceutical products and substances; medical products
and substances; veterinary preparations and substances;
biological preparations for pharmaceutical use; reagents
for medical, surgical, veterinary and dental use; diagnostic
reagents for medical, surgical, veterinary and dental use;
chemical products intended for use in chromatography
(medical, surgical, dental and veterinary). Diagnostic apparatus for non-medical use; testing apparatus
for non-medical use; scientific apparatus and instruments
for therapeutic, diagnostic and analytical use purposes,
namely protein chips or DNA chips; scientific apparatus,
namely, protein synthesis apparatus, purification of
proteins and biomolecules, protein deposition, imaging for
identification of molecular interactions; biosensors and
sensors (measuring apparatus and instruments). Research and development of new products regarding science
and medicine; laboratory services, namely diagnostic and
research services with respect to medicine, pharmaceuticals
and biotechnology provided by a laboratory.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical products for use in industry and science; chemical
reagents (other than for medical or veterinary use);
chemical diagnostic reagents for industrial use; chemical
substances intended for separation (other than for medical
or veterinary purposes). Pharmaceutical products and substances; medical products
and substances; veterinary preparations and substances;
biological preparations for pharmaceutical use; reagents
for medical, surgical, veterinary and dental use; diagnostic
reagents for medical, surgical, veterinary and dental use;
chemical products intended for use in chromatography
(medical, surgical, dental and veterinary). Diagnostic apparatus for non-medical use; testing apparatus
for non-medical use; scientific apparatus and instruments
for therapeutic, diagnostic and analytical use purposes,
namely protein chips or DNA chips; scientific apparatus,
namely, protein synthesis apparatus, purification of
proteins and biomolecules, protein deposition, imaging for
identification of molecular interactions; biosensors and
sensors (measuring apparatus and instruments). Medical apparatus and instruments; screening apparatus and
instruments for medical use; separation apparatus and
instruments for medical use; chromatography apparatus and
instruments for medical use. Research and development of new products regarding science
and medicine; laboratory services, namely medical,
pharmaceutical and biological research and diagnostic
services provided by a laboratory.
16.
BINDERS FOR INHIBITING FORMATION OF MULTIMERIC PROTEINS
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that are able to bind a subunit of a multimeric protein and inhibit the formation of the multimer.
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C40B 30/04 - Procédés de criblage des bibliothèques en mesurant l'aptitude spécifique à se lier à une molécule cible, p. ex. liaison anticorps-antigène, liaison récepteur-ligand
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
11 - Appareils de contrôle de l'environnement
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical products for use in industry and science; chemical
reagents (except for medical and veterinary use); chemical
diagnostic reagents for industrial use; chemical substances
intended for separation (other than for medical or
veterinary purposes); chemical substances, chemical
materials and chemical products, and natural elements;
chemical products for the purification of proteins for
in-vitro use; media for chromatography other than for
medical use; chromatography media for scientific
laboratories; substances for laboratory use; laboratory
reagents for scientific use; diagnostic reagents for
scientific use or for research; proteins for scientific
purposes; chemical products for use in scientific
diagnosis; laboratory chemicals for scientific use;
biochemical products for in-vitro and in-vivo scientific
use; proteins for use in industry; chemical products for
use in chromatography, other than for medical or veterinary
use. Biochemical preparations for medical use; biochemical
preparations for veterinary use; biological preparations
for veterinary use; biological preparations for medical
use; chemical preparations for medical use; chemical
preparations for veterinary use; medical preparations;
reagents for medical use; pharmaceutical preparations and
substances; biological reagents for medical use; biological
reagents for veterinary use; reagents and substances for
medical and veterinary diagnostic purposes; diagnostic
reagents for medical use; chemical reagents for medical or
veterinary use. Diagnostic apparatus for non-medical use; testing apparatus
not for medical use; scientific apparatus and instruments;
chromatography apparatus for laboratory or scientific use;
separation apparatus for laboratories; laboratory apparatus
and instruments; chromatography columns for laboratory use;
separation columns for scientific purposes. Medical apparatus and instruments; instruments for medical
use; separation instruments for medical use; chromatography
instruments for medical use; chromatography columns for
medical use; affinity chromatography columns for medical
use. Chromatography columns for industrial use; chemical
treatment equipment; chromatography apparatus for
industrial use. Medical and pharmacological research services; scientific
laboratory services; biological laboratory services;
research and development in the field of biotechnology;
research and development for the pharmaceutical industry;
research and development of new products; scientific
research and development.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical reagents other than for medical or veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes Pharmaceutical products and substances for the treatment of cancers, inflammation, neurologic disorders and immune system related diseases and disorders; diagnostic preparations and substances for veterinary purposes; biological preparations for pharmaceutical use, namely, biological preparations for the treatment of cancers, inflammation, neurologic disorders, and immune system related diseases and disorders; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in medical, surgical, dental and veterinary chromatography Diagnostic apparatus for non-medical use, namely, diagnostic apparatus for testing food; testing apparatus for non-medical use, namely, electronic and optical analyzers for testing chemical and biological substances for the presence, absence and quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for diagnostic and analytical use purposes, namely, protein chips and DNA chips; scientific apparatus for use in protein purification; measuring apparatus and instruments, namely, electronic portable analyzers for detecting biological agents Research and development of new products regarding science and medicine; laboratory services, namely, diagnostic and research services with respect to medicine, pharmaceuticals and biotechnology provided by a laboratory
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
11 - Appareils de contrôle de l'environnement
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical reagents, other than for medical and veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; chemical products for the purification of proteins for in-vitro use; media for chromatography other than for medical use, namely, for separation of a mixture into components; chromatography media for scientific laboratories, namely, for separation of a mixture into components; diagnostic laboratory reagents for scientific use; diagnostic reagents for scientific use or for research; proteins in raw material form for scientific research purposes; chemical products for use in scientific diagnosis, not for medical or veterinary purposes; biochemical products for in-vitro and in-vivo scientific use; proteins for use in industry; chemical products for use in chromatography, other than for medical or veterinary use Biochemical preparations for medical use, namely, for the detection and the diagnosis of cancers, inflammation, neurologic disorders, immune system related diseases and disorders; diagnostic preparations for medical purposes; reagents for medical use; biological reagents for medical use; reagents and substances for medical and veterinary diagnostic purposes; diagnostic reagents for medical use; chemical reagents for medical or veterinary use Diagnostic apparatus for the detection of pathogens, allergens and contaminants for laboratory or research use and not for medical use; testing apparatus not for medical use, namely, electronic analyzers for testing chemical and biological substances for the presence, absence, or quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for measuring relative DNA, RNA and proteins and parts and fittings therefor; chromatography apparatus for laboratory or scientific use; separation apparatus for laboratories, namely, pre-packed columns, laboratory filters and hollow fiber membranes for use in separation; chromatography columns for laboratory use; separation columns for scientific purposes Separation instruments, namely, gas chromatography apparatus for medical use; chromatography instruments for medical use; chromatography columns for medical use; affinity chromatography columns for medical use Chromatography columns for industrial use; chromatography apparatus for industrial use Medical and pharmacological research services; scientific laboratory services; biological laboratory services; research and development in the field of biotechnology; research and development for the pharmaceutical industry; research and development of new products; scientific research and development
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical reagents other than for medical or veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes Pharmaceutical products and substances for the treatment of cancers, inflammation, neurologic disorders and immune system related diseases and disorders; diagnostic preparations and substances for veterinary purposes; biological preparations for pharmaceutical use, namely, biological preparations for the treatment of cancers, inflammation, neurologic disorders, and immune system related diseases and disorders; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in medical, surgical, dental and veterinary chromatography Diagnostic apparatus for non-medical use, namely, diagnostic apparatus for testing food; testing apparatus for non-medical use, namely, electronic and optical analyzers for testing chemical and biological substances for the presence, absence and quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for diagnostic and analytical use purposes, namely, protein chips and DNA chips; scientific apparatus for use in protein purification; measuring apparatus and instruments, namely, electronic portable analyzers for detecting biological agents Research and development of new scientific and medical products; laboratory services, namely, diagnostic and research services with respect to medicine, pharmaceuticals and biotechnology provided by a laboratory
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical products for use in industry and science; chemical
reagents (except for medical and veterinary use); chemical
diagnostic reagents for industrial use; chemical substances
intended for separation (other than for medical or
veterinary purposes). Pharmaceutical products and substances; medical products
and substances; veterinary preparations and substances;
biological preparations for pharmaceutical use; reagents
for medical, surgical, veterinary and dental use; diagnostic
reagents for medical, surgical, veterinary and dental use;
chemical products intended for use in chromatography
(medical, surgical, dental and veterinary). Diagnostic apparatus for non-medical use; testing apparatus
for non-medical use; scientific apparatus and instruments
for therapeutic, diagnostic and analytical use purposes,
namely protein chips or DNA chips; scientific apparatus,
namely, protein synthesis apparatus, purification of
proteins and biomolecules, protein deposition, imaging for
identification of molecular interactions; biosensors and
sensors (measuring apparatus and instruments). Research and development of new scientific and medical
products; laboratory services, namely diagnostic and
research services with respect to medicine, pharmaceuticals
and biotechnology provided by a laboratory.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical reagents other than for medical or veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes Pharmaceutical products and substances for the treatment of cancers, inflammation, neurologic disorders and immune system related diseases and disorders; diagnostic preparations and substances for veterinary purposes; biological preparations for pharmaceutical use, namely, biological preparations for the treatment of cancers, inflammation, neurologic disorders, and immune system related diseases and disorders; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in medical, surgical, dental and veterinary chromatography Diagnostic apparatus for non-medical use, namely, diagnostic apparatus for testing food; testing apparatus for non-medical use, namely, electronic and optical analyzers for testing chemical and biological substances for the presence, absence and quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for diagnostic and analytical use purposes, namely, protein chips and DNA chips; scientific apparatus for use in protein purification; measuring apparatus and instruments, namely, electronic portable analyzers for detecting biological agents Medical apparatus and instruments for use in surgery and medical imaging; medical apparatus and instruments for cardiac screening, cancer screening and infection screening; blood component separation apparatus and instruments for medical use; chromatography apparatus and instruments for medical use Research and development of new products regarding science and medicine; laboratory services, namely, medical, pharmaceutical and biological research and diagnostic services provided by a laboratory
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
11 - Appareils de contrôle de l'environnement
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals for use in industry and science; Chemical reagents, other than for medical or veterinary purposes; Chemical diagnostic reagents for industrial use; Chemical substances for use in separation [other than medical or veterinary use]; Chemical substances, chemical materials and chemical preparations, and natural elements; Chemicals for use in the purification of proteins for in vitro use; Media for use in chromatography [not medical]; Chromatographic supports for scientific laboratory use; Substances for laboratory use; Laboratory reagents for scientific use; Diagnostic reagents for scientific or research use; Proteins for use in science; Chemical products for diagnostic use [scientific]; Laboratory chemicals for scientific use; Biochemicals for in vitro and in vivo scientific use; Proteins for use in industry; Chemicals for use in chromatography [other than medical and veterinary]. Biochemical preparations for medical use; Biochemical preparations for veterinary use; Biological preparations for veterinary purposes; Biological preparations for medical purposes; Chemical preparations for medical purposes; Chemical preparations for veterinary purposes; Medical preparations; Reagents for medical use; Pharmaceutical preparations and substances; Biological reagents for medical use; Biological reagents for veterinary use; Reagents and media for medical and veterinary diagnostic purposes; Diagnostic reagents for medical use; Chemical reagents for medical or veterinary purposes. Diagnostic apparatus, not for medical purposes; Testing apparatus not for medical purposes; Scientific apparatus and instruments; Chromatographs for scientific or laboratory use; Separating apparatus for laboratory use; Laboratory apparatus and instruments; Chromatography columns; Separation columns for scientific purposes. Medical apparatus and instruments; Medical instruments; Separation instruments for medical use; Chromatographic instruments for medical use; Chromatographic columns for medical use; Columns for affinity chromatography [for medical use]. Chromatography columns for industrial use; Chemical processing equipment; Chromatography apparatus for industrial purposes. Medical and pharmacological research services; Scientific laboratory services; Biological laboratory services; Research and development in the field of biotechnology; Research and development for the pharmaceutical industry; Research and development of new products; Scientific research and development.
The invention relates to proteins having multi-specific binding abilities byfusion of an OB-fold variant, in particular from the Sac7d family,to the light or heavy chain of an antibody.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry and science; chemical reagents (other than for medical or veterinary purposes); chemical diagnostic reagents for industrial use; chemical substances for use in separation (other than for medical or veterinary purposes). Pharmaceutical preparations and substances; medical substances and preparations; veterinary substances and preparations; Biological preparations for pharmaceutical purposes; reagents for medical, surgical, veterinary and dental purposes; diagnostic reagents for medical, surgical, veterinary and dental purposes; chemicals for use in chromatography (medical, surgical, dental and veterinary). Diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; scientific apparatus and instruments for therapeutic, diagnostic and analytical purposes, namely protein chips or DNA chips; scientific apparatus, namely apparatus for synthesising proteins, purifying proteins and biomolecules, depositing proteins, imaging for identifying molecular interactions; sensors and biosensors (apparatus and measuring instruments). Scientific and medical research and development; laboratory work, namely medical, pharmaceutical and biotechnological research and diagnosis carried out by a laboratory.
30.
ORAL ADMINISTRATION COMPOSITIONS COMPRISING AN OB-FOLD PROTEIN VARIANT
The invention relates to proteins having multi-specific binding abilities byfusion of an OB-fold variant, in particular from the Sac7d family,to the light or heavy chain of an antibody.
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind PD-L1 or HSP110 and are able to be used alone or in combination for cancer treatment.
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind to human and mouse serum albumin and that can be used to increase serum half-life of elements associated therewith.
The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the human leptin receptor and is able to trigger the crossing of the intestinal barrier, in particular of biologicals associated with it.
