01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Proteins for use in industry; proteins for use in
manufacture; proteins for use in science; proteins for use
in the manufacture of pharmaceutical products; raw proteins;
raw proteins for use in industry; raw proteins for use in
manufacture; raw proteins for use in science; raw proteins
for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic
solvents; purification of proteins; purification of proteins
by chemical methods. Scientific research and development services; drug discovery
services; development of pharmaceutical preparations and
medicines; drug screening for scientific purposes;
pharmaceutical drug development services; research and
development of vaccines and medicines; research and
development of drugs; research relating to medicines;
services for assessing the efficacy of drugs; conducting
early evaluations in the field of new pharmaceuticals;
consultancy in the field of pharmaceutical research;
consultancy relating to pharmaceutical research and
developments; development of pharmaceutical preparations and
medicines; inspection of pharmaceuticals; laboratory
research services relating to pharmaceuticals;
pharmaceutical drug development services; pharmaceutical
product evaluation; pharmaceutical research and development;
proving medical and scientific research information in the
field of pharmaceuticals and drug development; research and
development in the pharmaceutical and drug development
fields; testing of pharmaceutical drugs; assay development
services; biological research; biological analysis;
biological development services; biological laboratory
services; biological research, clinical research and medical
research; consultancy relating to pharmacology; medical and
pharmacological research services; scientific research for
medical purposes; research in the field of synthetic
biology; research and development in the field of
microorganisms and cells; chemical research and analysis
services; chemical engineering; chemistry services;
medicinal, synthetic, analytical and high throughput
chemistry services; clinical research; organic chemistry
research and analysis services; consultancy in the field of
organic chemistry; laboratory research and analysis services
in the field of organic chemistry; research and development
services in the field of organic chemistry; development,
testing and analysis of chemicals; development, testing and
analysis of chemical production methods; protein and peptide
mapping for scientific purposes; scientific analysis
services; protein analysis services for scientific purposes;
protein sequencing research; protein crystallisation
screening for scientific purposes; quality control; testing
of materials; testing of products; technological research;
industrial analysis and research services; scientific
services relating to cell line generation; scientific
screening services; compound profiling and selectivity
services; X-ray imaging, other than for medical purposes;
blood analysis services; blood analysis services for
scientific research purposes; information, advisory and
consultancy services relating to the aforesaid services.
01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Proteins for use in industry; proteins for use in
manufacture; proteins for use in science; proteins for use
in the manufacture of pharmaceutical products; raw proteins;
raw proteins for use in industry; raw proteins for use in
manufacture; raw proteins for use in science; raw proteins
for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic
solvents; purification of proteins; purification of proteins
by chemical methods. Scientific research and development services; drug discovery
services; development of pharmaceutical preparations and
medicines; drug screening for scientific purposes;
pharmaceutical drug development services; research and
development of vaccines and medicines; research and
development of drugs; research relating to medicines;
services for assessing the efficacy of drugs; conducting
early evaluations in the field of new pharmaceuticals;
consultancy in the field of pharmaceutical research;
consultancy relating to pharmaceutical research and
developments; development of pharmaceutical preparations and
medicines; inspection of pharmaceuticals; laboratory
research services relating to pharmaceuticals;
pharmaceutical drug development services; pharmaceutical
product evaluation; pharmaceutical research and development;
proving medical and scientific research information in the
field of pharmaceuticals and drug development; research and
development in the pharmaceutical and drug development
fields; testing of pharmaceutical drugs; assay development
services; biological research; biological analysis;
biological development services; biological laboratory
services; biological research, clinical research and medical
research; consultancy relating to pharmacology; medical and
pharmacological research services; scientific research for
medical purposes; research in the field of synthetic
biology; research and development in the field of
microorganisms and cells; chemical research and analysis
services; chemical engineering; chemistry services;
medicinal, synthetic, analytical and high throughput
chemistry services; clinical research; organic chemistry
research and analysis services; consultancy in the field of
organic chemistry; laboratory research and analysis services
in the field of organic chemistry; research and development
services in the field of organic chemistry; development,
testing and analysis of chemicals; development, testing and
analysis of chemical production methods; protein and peptide
mapping for scientific purposes; scientific analysis
services; protein analysis services for scientific purposes;
protein sequencing research; protein crystallisation
screening for scientific purposes; quality control; testing
of materials; testing of products; technological research;
industrial analysis and research services; scientific
services relating to cell line generation; scientific
screening services; compound profiling and selectivity
services; X-ray imaging, other than for medical purposes;
blood analysis services; blood analysis services for
scientific research purposes; information, advisory and
consultancy services relating to the aforesaid services.
01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. (1) Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods.
(2) Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods. Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods. Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. (1) Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods.
(2) Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.
C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 311/24 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
8.
SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
A61P 37/00 - Drugs for immunological or allergic disorders
C07C 1/00 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
C07D 217/16 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
C07D 307/85 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
C07D 311/24 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
C07D 311/68 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
C07D 317/68 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 319/20 - 1,4-DioxanesHydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
