01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Proteins for use in industry; proteins for use in
manufacture; proteins for use in science; proteins for use
in the manufacture of pharmaceutical products; raw proteins;
raw proteins for use in industry; raw proteins for use in
manufacture; raw proteins for use in science; raw proteins
for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic
solvents; purification of proteins; purification of proteins
by chemical methods. Scientific research and development services; drug discovery
services; development of pharmaceutical preparations and
medicines; drug screening for scientific purposes;
pharmaceutical drug development services; research and
development of vaccines and medicines; research and
development of drugs; research relating to medicines;
services for assessing the efficacy of drugs; conducting
early evaluations in the field of new pharmaceuticals;
consultancy in the field of pharmaceutical research;
consultancy relating to pharmaceutical research and
developments; development of pharmaceutical preparations and
medicines; inspection of pharmaceuticals; laboratory
research services relating to pharmaceuticals;
pharmaceutical drug development services; pharmaceutical
product evaluation; pharmaceutical research and development;
proving medical and scientific research information in the
field of pharmaceuticals and drug development; research and
development in the pharmaceutical and drug development
fields; testing of pharmaceutical drugs; assay development
services; biological research; biological analysis;
biological development services; biological laboratory
services; biological research, clinical research and medical
research; consultancy relating to pharmacology; medical and
pharmacological research services; scientific research for
medical purposes; research in the field of synthetic
biology; research and development in the field of
microorganisms and cells; chemical research and analysis
services; chemical engineering; chemistry services;
medicinal, synthetic, analytical and high throughput
chemistry services; clinical research; organic chemistry
research and analysis services; consultancy in the field of
organic chemistry; laboratory research and analysis services
in the field of organic chemistry; research and development
services in the field of organic chemistry; development,
testing and analysis of chemicals; development, testing and
analysis of chemical production methods; protein and peptide
mapping for scientific purposes; scientific analysis
services; protein analysis services for scientific purposes;
protein sequencing research; protein crystallisation
screening for scientific purposes; quality control; testing
of materials; testing of products; technological research;
industrial analysis and research services; scientific
services relating to cell line generation; scientific
screening services; compound profiling and selectivity
services; X-ray imaging, other than for medical purposes;
blood analysis services; blood analysis services for
scientific research purposes; information, advisory and
consultancy services relating to the aforesaid services.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Proteins for use in industry; proteins for use in
manufacture; proteins for use in science; proteins for use
in the manufacture of pharmaceutical products; raw proteins;
raw proteins for use in industry; raw proteins for use in
manufacture; raw proteins for use in science; raw proteins
for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic
solvents; purification of proteins; purification of proteins
by chemical methods. Scientific research and development services; drug discovery
services; development of pharmaceutical preparations and
medicines; drug screening for scientific purposes;
pharmaceutical drug development services; research and
development of vaccines and medicines; research and
development of drugs; research relating to medicines;
services for assessing the efficacy of drugs; conducting
early evaluations in the field of new pharmaceuticals;
consultancy in the field of pharmaceutical research;
consultancy relating to pharmaceutical research and
developments; development of pharmaceutical preparations and
medicines; inspection of pharmaceuticals; laboratory
research services relating to pharmaceuticals;
pharmaceutical drug development services; pharmaceutical
product evaluation; pharmaceutical research and development;
proving medical and scientific research information in the
field of pharmaceuticals and drug development; research and
development in the pharmaceutical and drug development
fields; testing of pharmaceutical drugs; assay development
services; biological research; biological analysis;
biological development services; biological laboratory
services; biological research, clinical research and medical
research; consultancy relating to pharmacology; medical and
pharmacological research services; scientific research for
medical purposes; research in the field of synthetic
biology; research and development in the field of
microorganisms and cells; chemical research and analysis
services; chemical engineering; chemistry services;
medicinal, synthetic, analytical and high throughput
chemistry services; clinical research; organic chemistry
research and analysis services; consultancy in the field of
organic chemistry; laboratory research and analysis services
in the field of organic chemistry; research and development
services in the field of organic chemistry; development,
testing and analysis of chemicals; development, testing and
analysis of chemical production methods; protein and peptide
mapping for scientific purposes; scientific analysis
services; protein analysis services for scientific purposes;
protein sequencing research; protein crystallisation
screening for scientific purposes; quality control; testing
of materials; testing of products; technological research;
industrial analysis and research services; scientific
services relating to cell line generation; scientific
screening services; compound profiling and selectivity
services; X-ray imaging, other than for medical purposes;
blood analysis services; blood analysis services for
scientific research purposes; information, advisory and
consultancy services relating to the aforesaid services.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. (1) Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods.
(2) Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods. Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods. Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Proteins for use in industry; proteins for use in manufacture; proteins for use in science; proteins for use in the manufacture of pharmaceutical products; raw proteins; raw proteins for use in industry; raw proteins for use in manufacture; raw proteins for use in science; raw proteins for use in the manufacture of pharmaceutical products. (1) Processing of organic chemical liquids; recycling of organic solvents; purification of proteins; purification of proteins by chemical methods.
(2) Scientific research and development services; drug discovery services; development of pharmaceutical preparations and medicines; drug screening for scientific purposes; pharmaceutical drug development services; research and development of vaccines and medicines; research and development of drugs; research relating to medicines; services for assessing the efficacy of drugs; conducting early evaluations in the field of new pharmaceuticals; consultancy in the field of pharmaceutical research; consultancy relating to pharmaceutical research and developments; development of pharmaceutical preparations and medicines; inspection of pharmaceuticals; laboratory research services relating to pharmaceuticals; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; proving medical and scientific research information in the field of pharmaceuticals and drug development; research and development in the pharmaceutical and drug development fields; testing of pharmaceutical drugs; assay development services; biological research; biological analysis; biological development services; biological laboratory services; biological research, clinical research and medical research; consultancy relating to pharmacology; medical and pharmacological research services; scientific research for medical purposes; research in the field of synthetic biology; research and development in the field of microorganisms and cells; chemical research and analysis services; chemical engineering; chemistry services; medicinal, synthetic, analytical and high throughput chemistry services; clinical research; organic chemistry research and analysis services; consultancy in the field of organic chemistry; laboratory research and analysis services in the field of organic chemistry; research and development services in the field of organic chemistry; development, testing and analysis of chemicals; development, testing and analysis of chemical production methods; protein and peptide mapping for scientific purposes; scientific analysis services; protein analysis services for scientific purposes; protein sequencing research; protein crystallisation screening for scientific purposes; quality control; testing of materials; testing of products; technological research; industrial analysis and research services; scientific services relating to cell line generation; scientific screening services; compound profiling and selectivity services; X-ray imaging, other than for medical purposes; blood analysis services; blood analysis services for scientific research purposes; information, advisory and consultancy services relating to the aforesaid services.
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.
C07D 231/12 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
C07D 311/24 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des atomes d'oxygène ou de soufre liés directement en position 4 avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement en position 2
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
8.
SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
C07C 1/00 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure
C07D 209/08 - IndolesIndoles hydrogénés avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone de l'hétérocycle
C07D 217/16 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec des radicaux, substitués par des hétéro-atomes, liés aux atomes de carbone du cycle contenant l'azote autres que des radicaux aralkyle substitués par des atomes d'oxygène
C07D 307/85 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 2
C07D 311/24 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des atomes d'oxygène ou de soufre liés directement en position 4 avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement en position 2
C07D 311/68 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des substituants autres que des atomes d'oxygène ou de soufre en position 2 ou 4 avec des atomes d'azote liés directement en position 4
C07D 317/68 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
C07D 319/20 - Dioxanes-1, 4Dioxanes-1, 4 hydrogénés condensés avec des carbocycles ou avec des systèmes carbocycliques condensés avec un cycle à six chaînons avec des substituants liés à l'hétérocycle
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 413/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
