The present invention relates to a method for preparing benzaldehyde oximes of the general formula (I) and to the use thereof as important precursors for the synthesis of agrochemical and pharmaceutical active substances.
C07C 249/08 - Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
C07C 45/45 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by condensation
C07C 47/55 - Compounds having —CHO groups bound to carbon atoms of six-membered aromatic rings containing halogen
C07C 251/48 - Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
2.
LIPASE WITH IMPROVED STEREOSELECTIVITY AND LIPASE-BASED CHIRAL RESOLUTION METHODS
The present invention relates to proteins having improved lipase activity, nucleic acid molecules encoding respective proteins having improved lipase activity and methods for chiral resolution of secondary alcohols.
The invention relates to a method for collecting data on a field used for agriculture by combining flying remote and ground level sensing, wherein, in a first step, by means of ground level sensing at reference points on the field used for agriculture, the geographical position of the respective reference point is captured and at least one photographic recording of at least one weed on the field used for agriculture is made for each reference point; in a second step, flying remote sensing parameters are determined on the basis of the data from an image analysis of the photographic recordings of the at least one weed for each reference point; and, in a third step, at least the reference points on the field used for agriculture are photographically captured by means of flying remote sensing, wherein at least some of the flying remote sensing parameters determined in step b) are used for the flying remote sensing.
Systems, methods, and computer programs disclosed herein relate to the prediction of disease progression in patients suffering from chronic kidney disease (CKD).
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
5.
ANDROGEN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PATIENTS WITH BIOCHEMICAL RECURRENCE OF HORMONE SENSITIVE PROSTATE CANCER
Described herein are methods of treating patients with biochemical recurrence of hormone-sensitive prostate cancer using a drug product comprising an androgen receptor inhibitor, such as darolutamide.
A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
A61K 31/4166 - 1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Disclosed are substituted indanylaminotriazines and salts thereof, methods for the production thereof, and the use thereof as herbicides, in particular for controlling weeds and/or unwanted grasses in crop cultures and/or as plant growth regulators for influencing the growth of crop cultures. Also encompassed is the use of substituted indanylaminotriazines and salts thereof for the production of herbicidal agents, as well as herbicidal agents containing said compounds.
A01N 43/70 - Diamino-1,3,5-triazines with only one oxygen, sulfur or halogen atom or only one cyano, thiocyano (—SCN), cyanato (—OCN) or azido (—N3) group directly attached to a ring carbon atom
A01N 43/68 - 1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms with two or three nitrogen atoms directly attached to ring carbon atoms
7.
PROCESS FOR THE PREPARATION OF 2-(2-HYDROXYPHENOXY)ACETATES
The present invention relates to 2-(2-hydroxyphenoxy)acetates of formula (I) as well as to processes for the synthesis of such compounds and their use as important intermediates in the synthesis of agrochemical and pharmaceutical active ingredients.
C07C 67/03 - Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
C07C 69/712 - Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
8.
DEVICE FOR ASSISTING WITH THE CREATION OF IMAGE RECORDS, USE OF THE DEVICE AND METHOD FOR CREATING AN IMAGE RECORD
The subject of the present disclosure is a device for assisting with the generation of image recordings, and the use of the device for generating image recordings of plant parts and/or plant pests.
This present invention relates to a crystalline form of (6S)-5-[4′-Fluoro-2-(trifluoromethyl)biphenyl-4-yl]-6-methyl-3, 6-dihydro-2H-1,3,4-oxadiazin-2-one which is the polymorph C, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the treatment of disorders.
The present invention provides methods for the preparation of Compound (I) intermediate compounds and their use for the preparation of compound (I).
The present invention provides methods for the preparation of Compound (I) intermediate compounds and their use for the preparation of compound (I).
Disclosed are substituted indanylcarboxamides and salts thereof of formula (I), methods for the preparation thereof, and the use thereof as herbicides, in particular for controlling weeds and/or unwanted grasses in crop cultures and/or as plant growth regulators for influencing the growth of crop cultures. Also encompassed are the use of substituted indanylcarboxamides and salts thereof for the preparation of herbicidal agents, as well as herbicidal agents containing said compounds.
C07C 233/06 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
C07C 233/14 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
C07C 233/23 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
A01N 37/18 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof
12.
DATA STRUCTURE FOR PARTIALLY ELUCIDATED MOLECULAR STRUCTURES
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in agriculture, horticulture and forestry; Manures; Grain treatment preparations not included in other classes; Genes of seeds for agricultural production; Growing media Preparations for destroying vermin; Fungicides; Herbicide for agricultural use
14.
AGROCHEMICAL FORMULATIONS COMPRISING CRYSTALLINE FORM A OF 4-[(6-CHLORO-3-PYRIDYL-METHYL )(2,2-DIFL UOROETHYL )AMINO]FURAN-2(5H)-ONE
The present invention relates to agrochemical formulations comprising the crystalline form A of 4-[(6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino]furan-2(5H)-one of formula (I) and to its use in plant protection applications.
The present invention relates to agrochemical formulations comprising the crystalline form A of 4-[(6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino]furan-2(5H)-one of formula (I) and to its use in plant protection applications.
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
15.
SOLUBLE GUANYLATE CYCLASE ACTIVATORS FOR USE IN THE TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN WOMEN
The invention relates to soluble guanylate cyclase (sGC) activators, preferably (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoic acid (runcaciguat) and/or substituted pyrazolo piperidine carboxylic acids, preferably selected from the list consisting of 1-[1-{4-Chloro-4′-[4-(2-methylpropyl)piperazin-1-yl][1,1′-biphenyl]-2-yl}piperidin-3-yl]-5-(difluoromethyl)-1H-pyrazole-4-carboxylic acid, 1-{3(R)-1-[4-Chloro-4′-(4-isobutylpiperazin-1yl)[biphenyl]-2-yl]piperidin-3-yl}-5-(difluoromethyl)-1H-pyrazole-4-carboxylic acid, 1-{3(R)-1-[4-Chloro-4′-(4-isobutylpiperazin-1-yl)[biphenyl]-2-yl]piperidin-3-yl}-5-(difluoromethyl)-1H-pyrazole-4-carboxylic acid hydrochloride, 1-{3(R)-1-[4-Chloro-4′-(4-isobutylpiperazin-1-yl)[biphenyl]-2-yl]piperidin-3-yl}-5-(difluoromethyl)-1H-pyrazole-4-carboxylic acid hydrochloride hemihydrate or 1-[1-{4-chloro-4′-[4-(2-methylpropyl)piperazin-1-yl][1,1′-biphenyl]-2-yl}piperidin-3-yl]-5-(trifluoro-methyl)-1H-pyrazole-4-carboxylic acid hydrochloride (Enantiomer 1) for use in the treatment and/or prophylaxis of heart failure with preserved ejection fraction (HFpEF) in women and their use for preparing medicaments for the use in the treatment and/or prophylaxis of heart failure with preserved ejection fraction (HFpEF) in women.
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure
The application relates to an extraction method for purifying 3-phenyl-5-vinyl-4H-isoxazole-5-carboxylic acids of formulae (Ia) and/or (Ib), in particular those which are contaminated with by-products of a preceding elimination reaction.
C07D 261/04 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
18.
Solid formulation of insecticidal mixtures having particularly good dispersion properties
The invention relates to solid-state formulations (especially water-dispersible granules) of tetramic acid derivatives and mixtures of these tetramic acid derivatives that break down particularly efficiently in water and nevertheless have good long-term stability, and to a process for production thereof and to the use thereof for application of the active ingredients present.
A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
A01N 25/30 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
A01N 43/36 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
The present disclosure primarily relates to certain agrochemically active herbicidal combinations comprising (A) diflufenican and (B) mesotrione. The disclosure further relates to the use of these combinations for controlling weeds, in particular for controlling resistant weeds, and to corresponding methods.
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
The systems, methods and computer programs disclosed herein relate to the automated recognition of functional impairments with camera-monitored insect traps using machine learning methods.
G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
24.
COMBINATIONS OF DGK (DIACYLGLYCEROL KINASE) INHIBITORS
Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts (Germany)
Inventor
Kirchhoff, Dennis
Gorjanacz, Matyas
Petersen, Kirstin
Schmees, Norbert
Offringa, Rienk
Olesch, Catherine
Cichon, Frederik
Wengner, Antje Margret
Hethey, Christoph Phillipp
Abstract
The present invention covers combinations comprising one or more inhibitors of DGKalpha and one or more inhibitors of DGKzeta Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly of a condition with dysregulated immune responses, particularly cancer, or a viral infection or another disorder associated with aberrant DGKalpha and/or DGKzeta signaling.
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
Provided are liquid, solid, and semi-solid oral pharmaceutical compositions comprising a multi-component taste-masking physical barrier. The oral pharmaceutical compositions comprise an active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable excipients, a pH modifying agent, and the multi-component taste-masking physical barrier comprising one or more of an ion exchange resin, a cyclodextrin, and a hydrocolloid.
A topical composition, preferably an emulsion or wash, more preferably a (W/O) emulsion, (O/W) emulsion or wash, for use on the skin comprising: a. 0.01 to 8.00% of a selective prebiotic comprising: i. Xylitol, ii. Anhydroxylitol, and iii. Xylitylglucoside, b. at least one humectant, c. at least one provitamin, vitamin and/or vitamin derivate from provitamin, vitamin B3 and/or a salt thereof, preferably niacinamide, provitamin, vitamin B5 and/or a salt thereof, preferably dexpanthenol and/or provitamin, vitamin E and/or a salt thereof, preferably tocopheryl acetate, and d. at least two lipids from the list comprising or consisting of ceramides, cholesterol, cholesterol esters, triglycerides, free fatty acids, free fatty acid derivates including glyceryl oleate and ethyl linoleate, caprylic capric triglyceride, Butyrospermum parkii (shea) butter, shea butter derivatives, squalane and/or squalene. Said composition for use in the treatment and/or prevention of an acne and/or an eczema skin disease. Non-therapeutic use of said composition for strengthening the physical, biochemical and microbial layer of the skin, wherein the skin is newborn, infant, child, adolescent, adult or mature, preferably newborn and/or infant skin.
The present disclosure provides engineered type V nucleases suitable for editing eukaryotic genomic DNA, as well as methods of producing the nucleases, systems comprising the nucleases, as well as methods of using the nucleases and systems to edit eukaryotic genomic DNA.
Systems for artificial intelligence based event management may include at least one processor to receive data associated with an event involving a medical device via a user interface (UI) associated with the medical device; receive data associated with an identification characteristic of the medical device; generate an event message; wherein the event message comprises the data associated with the event involving the medical device and the data associated with the identification characteristic of the medical device; provide a response message via the UI associated with the medical device based on the data associated with the event involving the medical device; where the response message includes information based on an output of a generative and conversational artificial intelligence (AI) platform; determine a category of the event message; and perform an action based on the category of the event message. Methods and computer program products are also disclosed.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
29.
4-FLUOROALKYLBENZAMIDES AND THEIR USE AS HERBICIDES
4-Fluoroalkylbenzamides of formula (I) are described as herbicides. In this formula (I), X, Y, Z and R represent, inter alia, groups such as alkyl, cycloalkyl, haloalkyl and halogen.
C07D 257/06 - Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
A01N 43/713 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
The present disclosure relates to methods of treating metastatic castration-resistant prostate cancer (mCRPC) in a subject, comprising administering to the subject (a) darolutamide, and (b) Compound 1, or a pharmaceutically acceptable salt thereof, including those methods wherein the mCRPC in the subject has been determined to be resistant to one or more androgen receptor signaling inhibitors (ARSI), including, for example, abiraterone acetate.
The present invention relates to a composition comprising a) at least one biological control agent which is a fungicidally active bacterium and/or a fungicidally active metabolite produced by the respective bacterium and b) one or more fatty acids or derivatives thereof selected from unsaturated and saturated C12-24 fatty acids, salts thereof, esters thereof or mixtures of any of the foregoing as well as methods of using this composition and related uses.
The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a N-cyclopropyl-N-[substituted-benzyl]-3-(ditluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively or eradicatively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
A01N 43/84 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
A01N 55/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
Systems for operating a fluid injection system may include at least one processor to receive patient data associated with a patient undergoing a fluid injection procedure, automatically generate at least one parameter of an injection protocol for the fluid injection procedure based on the patient data and independent of an input associated with a dosage of a medical fluid for the fluid injection procedure received via a user interface associated with a fluid injection system that is to execute the fluid injection procedure, wherein, when automatically generating the at least one parameter, the at least one processor is to determine the dosage of the medical fluid for the fluid injection procedure, and provide the at least one parameter of the injection protocol to the fluid injection system. Methods and computer program products are also disclosed.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
The present disclosure relates to the technical field of precision farming. The subjects of the present invention are a device and a method for the precise application of a liquid to a target object in an agricultural field.
The invention relates to substituted S-alaninate derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07F 9/6558 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
40.
NEW CHEMICAL PROCESS FOR THE PRODUCTION OF 4-(4-FLUORO-2-METHYL-PHENYL)-5-NITRO- 1H-PYRIDIN-2-ONE, A KEY INTERMEDIATE OF ELINZANETANT
The present invention relates to a process for producing 4-(4-fluoro-2-methyl-phenyl)-5- nitro-1H-pyridin-2-one, a key intermediate of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4- fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1- c][1,4]oxazin-8(1H)-yl]pyridin-3-yl}-N,2-dimethylpropanamide (elinzanetant). Further, the invention relates to a compound of Formula (VII): [Formula should be inserted] wherein R1144-alkyl or optionally substituted phenyl; a compound being 3-(4- fluoro-2-methyl-phenyl)-4-nitro-butanamide; and a compound being 4-(4-fluoro-2-methyl- phenyl)-5-nitro-3,4-dihydro-1H-pyridin-2-one.
The present invention relates to a process for producing 4- (4-fluoro-2-methyl-phenyl) -5-nitro-1H-pyridin-2-one, a key intermediate of 2- [3, 5-bis (trifluoromethyl) phenyl] -N- {4- (4-fluoro-2-methylphenyl) -6- [ (7S, 9aS) -7- (hydroxymethyl) hexahydropyrazino [2, 1-c][1, 4] oxazin-8 (1H) -yl] pyridin-3-yl} -N, 2-dimethylpropanamide (elinzanetant). Further, the invention relates to a compound of Formula (VII), wherein R1144-alkyl or optionally substituted phenyl; a compound being 3- (4-fluoro-2-methyl-phenyl) -4-nitro-butanamide; and a compound being 4- (4-fluoro-2-methyl-phenyl)-5-nitro-3,4-dihydro-1H-pyridin-2-one.
The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
The invention relates to a lettuce plant (Lactuca sativa L.) comprising a resistance QTL which confers dual resistance to Fusarium oxysporum f.sp lactucae race Fol-1 and race Fol-4, wherein the QTL is located on chromosome 7. The invention further provides seeds, progeny, propagation material and food products from the plant.
A fluid injector system for reconstituting a solute contrast media and injecting reconstituted contrast media solution resulting therefrom includes a first syringe containing a diluent, a container containing the solute contrast media, a first valve configured to provide selective fluid communication between the container and the first syringe, and a controller. The controller is programmed or configured to deliver the diluent into the container to reconstitute the solute contrast media into a reconstituted contrast media solution, and deliver the reconstituted contrast media solution into an administration line configured to be fluidly connectable to a patient.
The present disclosure relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.
The present disclosure relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.
A01N 25/30 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
49.
Sequential one-pot synthesis for preparing 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
The present invention covers a sequential one-pot synthesis for preparing 4-(4-cyano-2-methoxy-phenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide according to formula (XIII). In particular, in the sequential one-pot synthesis (4R)-4-(4-cyano-2-methoxy-phenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide according to formula ent-(I) is used as starting material to obtain 4-(4-cyano-2-methoxy-phenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide according to formula (XIII) via electrochemical oxidation and electrochemical reduction.
The present disclosure provides engineered type V nucleases suitable for editing eukaryotic genomic DNA, as well as methods of producing the nucleases, systems comprising the nucleases, as well as methods of using the nucleases and systems to edit eukaryotic genomic DNA.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Cosmetics (for topical and oral application, and eye drops), for treatment of the skin, nose and eyes, including skin care products for use during pregnancy and while breastfeeding, and for babies, for the care of wounds and scars and for allergic and dry skin irritations, except hair care and hair styling products of all kinds, depilatories and hair dyes. Pharmaceuticals; medical preparations.
The present invention relates to a process for preparing of pure (3S)-Pyrrolidin-3-ol (“the base”) of formula (I), and the preparation of the corresponding (3S)-Pyrrolidin-3-ol hydrochloride (“the hydrochloride”) of formula (II).
The present invention relates to a process for preparing of pure (3S)-Pyrrolidin-3-ol (“the base”) of formula (I), and the preparation of the corresponding (3S)-Pyrrolidin-3-ol hydrochloride (“the hydrochloride”) of formula (II).
A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/28 - Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
A61B 5/296 - Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
Provided are topical analgesic gel compositions having relatively high payloads of menthol and camphor by micro-emulsion technology and methods of preparing topical analgesic gel compositions having relatively high payloads of menthol and camphor. Topical analgesic gel compositions may include from 12 to 16 wt. % menthol; from 4 to 8 wt. % camphor; from 0.1 to 2 wt. % carbomer; and 60 to 70 wt. % solvent. Topical analgesic gel compositions can have a viscosity from 60,000 to 110,000 centipoise.
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
56.
SYSTEM AND METHOD UTILIZING AN INTEGRATED CAMERA WITH A FLUID INJECTOR
A fluid injector system configured for use in administering at least one fluid to a patient, the fluid injector system including at least one image capture device configured for capturing image data in an environment surrounding the fluid injector system; and a control device comprising at least one processor programmed or configured to receive, with the at least one processor, the image data captured by the at least one image capture device; determine, with the at least one processor, whether the received image data comprises at least one predetermined characteristic; and perform, with the at least one processor, at least one action in response to determining whether the received image data comprises at least one predetermined characteristic.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
57.
INCREASED NITROGEN FIXATION USING BACTERIA WITH IMPROVED AMMONIA SECRETION
Herbaspirillum bacterial strains are engineered to express or overexpress one or more proteins and/or attenuate expression of or delete one or more genes involved in nitrogen fixation and its regulation. This enables the diazotrophic bacteria to secrete more ammonia. The engineered bacteria arc introduced to agricultural plants, or seeds for growing such, forming a symbiotic relationship that results in increased nitrogen availability to the plant and improved plant agronomic traits.
The computer-implemented methods, computer systems and non-transitory computer readable storage medium disclosed herein relate to predicting the bioavailability for at least one agricultural active ingredient with a trained machine learning model based on spectral data of soil of an agricultural field.
G01N 21/3554 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for determining moisture content
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
The invention also refers to finerenone or a hydrate, solvate, pharmaceutically acceptable salt thereof, or a polymorph thereof for use in the prevention or treatment of chronic kidney disease in a patient with type I diabetes, comprising administering to the patient a therapeutically effective amount of finerenone or a hydrate, solvate, pharmaceutically acceptable salt thereof, or a polymorph thereof.
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
The present invention deals with the selection of antibodies and/or antibody fragments in a selection method. Subjects of the present invention are a method, a system and a computer program product for generating score values for pairs of genes which encode the variable domains of light and heavy chains of antibodies and/or antibody fragments. Antibodies and/or antibody fragments can be selected on the basis of the score values.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Computationally implemented methods, computing systems and computer program products disclosed herein relate to the calculation of risk values for crop plant phytotoxicity based on the classification of digital images into vegetation classes, including additional agronomic data and the provision of agricultural recommendations based on these risk values.
The invention relates to novel herbicidal active compound combinations which comprise substituted isoxazolincarboxamides or agrochemical acceptable salts thereof and substituted aminopyridines and aminopyrimidines. They can be used with particularly good results for the control of weeds in various crops of useful plants.
A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Herbal Composition for Activation of the Endocannabinoid System The present invention relates to herbal compositions and methods to activate the endocannabinoid system in order to alleviate stress and its attendant adverse health effects.
The present invention relates to compositions containing herbicidally active compounds (A) and (B), wherein (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for control of harmful plants or for growth regulation.
A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
A01N 47/06 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing —O—CO—O— groupsThio-analogues thereof
3-Heterocyclylbenzamides of the formula (I) are described as herbicides. In this formula (I), X, Y, Z and Rx are radicals such as alkyl, cycloalkyl, haloalkyl and halogen.
A01N 43/713 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
C07D 261/04 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
C07D 261/08 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 263/32 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
70.
SUBSTITUTED ISOPHTHALIC ACID DIAMIDES AND USE THEREOF AS HERBICIDES
Isophthalamides of the formula (I) are described as herbicides. In this formula (I), X, Y, Z1, Z2 and Rx are radicals such as alkyl, cycloalkyl, haloalkyl and halogen.
A01N 43/713 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
C07C 235/42 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
C07D 257/06 - Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
71.
PRESSURE JACKETS AND SYRINGE RETENTION FEATURES FOR ANGIOGRAPHY FLUID INJECTORS
An assembly for retaining a pressure jacket and a syringe on a fluid injector, the assembly including a base plate comprising a body; at least a first retaining arm and a second retaining arm operatively mounted on the body of the base plate, the first retaining arm having a first retaining surface at a distal end thereof and the second retaining arm having a second retaining surface at a distal end thereof, wherein the first retaining surface and the second retaining surface are configured for abutting a distal surface of at least one of the pressure jacket and the syringe; a linkage assembly operatively connected to at least one of the first retaining arm and the second retaining arm, wherein the linkage assembly is configured to move at least one of the first retaining arm and the second retaining arm between at least a first open position and a closed position.
Sulfonimidoylbenzamides of the formula (I) are described as herbicides. In this formula (I), X, W, Z, R, R' and R" are radicals such as alkyl, cycloalkyl, haloalkyl and halogen.
A01N 43/82 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with three hetero atoms
Arylcarboxamides of the formula (I) are described as herbicides. In this formula (I), X, Y, Z and Rx are radicals such as alkyl, cycloalkyl, haloalkyl, and halogen.
A01N 43/713 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
C07C 317/02 - SulfonesSulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
C07D 257/06 - Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
3-Acylbenzamides of the formula (I) are described as herbicides. In this formula (I), X, Y, Z and Rx are radicals such as alkyl, cycloalkyl, haloalkyl and halogen.
A01N 43/713 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
C07D 257/06 - Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
The present invention relates to compositions comprising herbicidally active compounds (A) and (B), wherein (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a process and to the use of the herbicidal composition of the invention for the control of harmful plants or for growth regulation.
A01N 47/38 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the group N—CO—N where at least one nitrogen atom is part of a heterocyclic ringThio-analogues thereof
A fluid path connector for a medical fluid delivery system, the fluid path connector including a first connector element comprising a body, a first lumen, a first flexible leg, and a second flexible leg, and a second connector element comprising a body defining an undercut, a second lumen, a channel defined in the body, and at least one sealing element positioned within the channel, in which the first flexible leg comprises a first flange and the second flexible leg comprises a second flange, and in which, upon engagement of the first connector element with the second connector element, the first flange and the second flange engage with the undercut of the body of the second connector element to prevent disengagement of the first connector element and the second connector element.
The present invention relates to high dose VEGF antagonists for the treatment of angiogenic eye disorders secondary to retinal vein occlusion – such as vascular permeability, macular edema, retinal hemorrhage, and neovascularization – and for the treatment of retinal vein occlusion. The treatments include high doses of aflibercept and lengthening intervals between doses.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A system for providing a quick response (QR) code associated with an injection system is disclosed. The system includes the injection system and at least one processor. The at least one processor is programmed or configured to: receive data associated with the injection system; generate a network resource based on the data associated with the injection system, wherein, when generating the network resource, the at least one processor is programmed or configured to encode the data associated with the injection system into the network resource; generate a QR code based on the network resource; and display the QR code on a display screen of the injection system.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
What is described herein relates to a method for optimizing purification conditions of a protein of interest comprising: a) prediction of filtration performance of a protein of interest based on the hydrophobicity of said protein of interest and/or b) filtration of a protein of interest wherein the protein of interest has an isoelectric point in the range of between 3.0 and 7.5 and the filtration is earned out at a pH above the isoelectric point.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dietary food preparations for medical purposes; medical
preparations for use as additives for human consumption;
medical preparations and substances; pharmaceutical
preparations.
83.
GENERATION OF ARTIFICIAL CONTRAST-ENHANCED RADIOLOGICAL IMAGES
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/28 - Details of apparatus provided for in groups
G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
The present invention relates to regimens for the treatment of angiogenic eye disorders secondary to retinal vein occlusion, such as vascular permeability, macular edema, retinal hemorrhage, and neovascularization, and for treatment of retinal vein occlusion, characterized by high doses of aflibercept and lengthening intervals between doses.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 9/00 - Medicinal preparations characterised by special physical form
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
The present invention relates to compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application also relates to a process and to the use of the herbicidal composition according to the invention for controlling undesirable plants or regulating plant growth.
irir3.4, KCNJ5) inhibitory compounds, the preparation thereof and the use thereof for the treatment and/or prevention of diseases. These compounds can be used for the treatment and/or prevention of cardiovascular disorders. In one Example the disorder can be atrial fibrillation (AF) and/or other related cardiac arrhythmias.
A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
88.
BIFIDOBACTERIUM LONGUM SUBSP. INFANTIS CAPABLE OF ALLEVIATING AND PREVENTING ALLERGIC RHINITIS, AND USE THEREOF
Provided are a bifidobacterium longum subsp. infantis capable of alleviating and preventing allergic rhinitis, and a use thereof, relating to the technical fields of microorganisms and medicine. The bifidobacterium longum subsp. infantis CCFM111 can alleviate allergic reactions in allergic mice, and alleviate and prevent allergic disorders in patients with perennial allergic rhinitis. Specifically: (1) the bifidobacterium longum subsp. infantis CCFM111 alleviates weight loss and symptoms caused by allergies in mice, reduces pulmonary inflammation infiltration, lowers serum OVA-sIgE and total IgE levels, and regulates the expression of pro-inflammatory and anti-inflammatory factors. (2) The bifidobacterium longum subsp. infantis CCFM111 alleviates allergic symptoms and reduces medication scores in patients, increases the proportion of symptom-free days of patients, lowers the serum sIgE levels against dermatophagoides farinae and dermatophagoides pteronyssinus in patients, and regulates the expression of cytokines in the serum and nasal lavage fluid of patients. Therefore, the bifidobacterium longum subsp. infantis CCFM111 has broad prospects for application in the preparation of a product for preventing and/or treating allergic rhinitis.
Systems, methods, and computer programs disclosed herein relate to training and using a machine learning model to predict compositions and/or properties of formulations, in particular of active ingredient formulations.
The present invention relates to the technical field of the marking of articles by means of optically readable codes and of decoding the codes. Such a code is introduced into a surface of an article. The code is decoded on the basis of a transformed captured image of the code. The transformed captured image is generated from at least one captured image of the code using a machine learning model. The model is trained to generate a transformed captured image from at least one captured image and the readout of the optically readable code leads to less decoding errors than the readout of the code in the at least one captured image. The present invention relates to a method for training the machine learning model and to a method, a system and a computer program product for decoding a code using the trained machine learning model.
G06K 7/14 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
The present invention relates to a process for preparing (4S)-24-chloro-4-ethyl-73-fluoro-35- methoxy-32,5-dioxo-14-(trifluoromethyl)-32HH-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola- 2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide (I) from (Z)-2-bromobut-2-enoic acid (XXII), 4- amino-2-fluorobenzamide (XII) and 4-{5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1- yl]phenyl}-5-methoxypyridin-2(1H)-one (XV) with an enantioselective hydrogenation of the 5 double bond in the last synthesis step.
C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
C07C 237/30 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
The present invention relates to a process for preparing (4S)-24-chloro-4-ethyl-73-fluoro-35- methoxy-32,5-dioxo-14-(trifluoromethyl)-32H-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola- 2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide (I) from 2,5-dimethoxypyridine (II), 1-(2-bromo- 4-chlorophenyl)-4-(trifluoromethyl)-1H-1,2,3-triazole (IV), 4-amino-2-fluorbenzamide (IX) and (2R)-2-bromobutanoic acid - N-cyclohexylcyclohexanamine (XI).
C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
The present disclosure relates to monitoring arthropods on the basis of captured images. The subject matter of the present disclosure comprises a device, a system, and a method.
Medical instruments; medical devices; medical devices for the delivery of contraceptives; non-chemical contraceptives for delivery via devices; contraceptives (non-chemical) for the delivery via device; none of the aforementioned goods being Cardiac ablation catheters.
