Abrégé

The present invention relates to regimens for the treatment of angiogenic eye disorders such as nAMD, DR and DME characterized by high doses of aflibercept extended periods between doses.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/02 - Composés inorganiques
• A61K 47/18 - Amines; Amides; Urées; Composés d’ammonium quaternaire; Acides aminés; Oligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/22 - Composés hétérocycliques, p.ex. acide ascorbique, tocophérol ou pyrrolidones
• A61K 47/26 - Hydrates de carbone, p.ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharides; Leurs dérivés, p.ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61P 27/02 - Agents ophtalmiques

Produits et services

Software; application software; both relating to agriculture and the cultivation of fruits and vegetables. Providing temporary use of non-downloadable computer software; software as a service (SaaS); platform as a service (PaaS); platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables. Consultancy relating to horticulture; agriculture services; consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; horticulture services.

Abrégé

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Classes IPC  ?

• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique

Abrégé

The present invention relates to novel, herbicidally active (1,4,5-trisubstituted 1H-pyrazol-3-yl)oxy-2-alkoxyalkyl acids and their derivatives of the general formula (I) and their agrochemically compatible/acceptable salts, N-oxides, hydrates, and hydrates of the salts and N-oxides, to processes for preparation thereof and to the use thereof for control of broadleaved weeds and weed grasses in crops of useful plants, and for general control of broadleaved weeds and weed grasses in areas of the environment where plant growth is troublesome. The present invention relates to novel, herbicidally active (1,4,5-trisubstituted 1H-pyrazol-3-yl)oxy-2-alkoxyalkyl acids and their derivatives of the general formula (I) and their agrochemically compatible/acceptable salts, N-oxides, hydrates, and hydrates of the salts and N-oxides, to processes for preparation thereof and to the use thereof for control of broadleaved weeds and weed grasses in crops of useful plants, and for general control of broadleaved weeds and weed grasses in areas of the environment where plant growth is troublesome. The derivatives of the (1,4,5-trisubstituted 1H-pyrazol-3-yl)oxy-2-alkoxyalkyl acids include in particular their esters and/or amides.

Classes IPC  ?

• C07D 231/20 - Un atome d'oxygène lié en position 3 ou 5
• A01N 43/56 - Diazoles-1,2; Diazoles-1,2 hydrogénées

Abrégé

The present invention covers spirocyclic compounds of general formula (I), in which R1, R2, X, Y, and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant KRAS signaling, as a sole agent or in combination with other active ingredients.

Classes IPC  ?

• C07D 495/10 - Systèmes condensés en spiro
• C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
• A61P 35/00 - Agents anticancéreux

Produits et services

Non-medicated cosmetics and toiletry preparations. Pharmaceutical preparations for medical purposes; sanitary preparations for medical purposes; Dietetic substances adapted for medical use; dietary supplements for human beings; food supplements.

Produits et services

Software; application software; both relating to agriculture and the cultivation of fruits and vegetables. Providing temporary use of non-downloadable computer software; software as a service (SaaS); platform as a service (PaaS); platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables. Consultancy relating to horticulture; agriculture services; consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; horticulture services.

Abrégé

The present invention relates to aqueous dispersions comprising an ALS inhibitor, typically a sulfonylurea herbicide, specifically from the class of triazolinones herbicides, a HPPD inhibitor, specifically a triketone as from the class of 2-benzoyl-1,3-cyclohexanedione herbicides, optionally a safener from the class of the sulfonamides, a water-soluble herbicide present as a salt, specifically glyphosate and to dispersions resulting from dispersing the concentrate suspension in water, to a method of making the aqueous suspension and to a method of controlling unwanted plants using these dispersions.

Classes IPC  ?

• A01N 47/38 - Urées ou thiourées contenant les groupes N—CO—N ou N—CS—N contenant le groupe N—CO—N avec au moins un atome d'azote faisant partie d'un hétérocycle; Leurs thio-analogues
• A01N 25/04 - Dispersions ou gels
• A01N 41/10 - Sulfones; Sulfoxydes
• A01N 57/12 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques du phosphore comportant des liaisons phosphore-oxygène ou des liaisons phosphore-soufre contenant des radicaux acycliques ou cycloaliphatiques
• A01P 13/02 - Herbicides; Algicides sélectifs

Abrégé

A fluid delivery system and method for determining whether the correct fluid is being drawn into and/or dispensed from a syringe. The system includes a syringe, a fluid injector for drawing fluid into and dispensing fluid from the syringe, one or more sensors adapted to measure a force required to draw the fluid into and/or dispense the fluid from the syringe, a processor in communication with the one or more sensors, and a non-transitory, computer-readable storage medium in operable communication with the processor. The computer-readable storage medium contains one or more programming instructions that, when executed, cause the processor to receive from the one or more sensors one or more measurements of the force required to draw the fluid into and/or dispense the fluid from the syringe and determine from the one or more measurements whether a correct fluid is being drawn into and/or dispensed from the syringe.

Classes IPC  ?

• A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p.ex. compteurs de goutte-à-goutte
• A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
• G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p.ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection

Produits et services

Software; application software; both relating to agriculture and the cultivation of fruits and vegetables. Providing temporary use of non-downloadable computer software; software as a service (SaaS); platform as a service (PaaS); platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables. Consultancy relating to horticulture; agriculture services; consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; horticulture services.

Abrégé

A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engageable with the piston regardless of a rotational orientation of the piston relative to the plunger.

Classes IPC  ?

• A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
• A61M 5/315 - Pistons; Tiges de piston; Guidage, blocage, ou limitation des mouvements de la tige; Accessoires disposés sur la tige pour faciliter le dosage

Abrégé

The present invention relates to the technical field of producing synthetic medical images. The subject matter of the present disclosure relates to a method, a computer system and a computer-readable storage medium comprising a computer program for identifying artifacts in synthetic medical images.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 11/00 - Génération d'images bidimensionnelles [2D]

Abrégé

Systems for providing a medical procedure plan may include a fluid injector and at least one processor to select a specific dosage amount of a contrast agent from a plurality of dosage amounts of the contrast agent that is to be administered by a fluid injection system during an injection procedure for a patient; automatically execute an injection protocol for the injection procedure based on selecting the specific dosage amount of the contrast agent from the plurality of dosage amounts of contrast agent where the injection protocol includes the specific dosage amount; generate an image of an area of a body of the patient based on automatically executing the injection protocol; generate an image analysis result of the image of the area of the body of the patient; and determine whether the image analysis result satisfies a threshold of image quality. Methods, fluid injectors, and components thereof are also disclosed.

Classes IPC  ?

• G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p.ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p.ex. l’édition
• A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
• A61B 6/00 - Appareils pour diagnostic par radiations, p.ex. combinés avec un équipement de thérapie par radiations

Abrégé

The present invention relates to a composition comprising (a) one or more fatty acids or derivatives thereof selected from unsaturated and saturated C12-24 fatty acids, salts thereof, esters thereof or mixtures of any of the foregoing; and (b) a water conditioner comprising an organic acid and one or more compound according to Formula (I), (I), as well as methods and uses thereof. The invention is useful for alleviating the effects of hard water on the applicability of plant protection products based on fatty acids and derivatives thereof.

Classes IPC  ?

• A01N 37/04 - Acides carboxyliques saturés ou leurs thio-analogues; Leurs dérivés polybasiques
• A01P 3/00 - Fongicides
• A01P 7/04 - Insecticides

Abrégé

Systems and methods are provided that includes the processing of video material for reducing video material to temporal segments in which a significant movement of an object is recorded. The systems and methods may be used for the observation of animals.

Classes IPC  ?

• G06T 7/215 - Découpage basé sur le mouvement
• G06T 5/70 - Débruitage; Lissage
• G06T 7/254 - Analyse du mouvement impliquant de la soustraction d’images
• G06V 40/10 - Corps d’êtres humains ou d’animaux, p.ex. occupants de véhicules automobiles ou piétons; Parties du corps, p.ex. mains

Abrégé

12-244 fatty acids, salts thereof, esters thereof or mixtures of any of the foregoing; and (b) one or more compound according to Formula (I) as well as methods and uses thereof.

Classes IPC  ?

• A01P 3/00 - Fongicides
• A01P 7/04 - Insecticides
• A01N 37/02 - Acides carboxyliques saturés ou leurs thio-analogues; Leurs dérivés

Abrégé

The present invention primarily relates to kits for preparing herbicidal application mixtures (agronomic application mixtures, application compositions) comprising or consisting of two physically separate compositions in the form of Component A and Component B as defined herein. The present invention further relates to a method for producing application mixtures using said kit. Further, the present invention relates to certain compositions suitable as Components B useful as part of kits of the present invention. Also, the present invention also relates to the use of the kits of the present invention for controlling undesired vegetation and to corresponding methods.

Classes IPC  ?

• A01N 25/04 - Dispersions ou gels
• A01N 25/24 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'application; Substances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des ingrédients augmentant l'adhérence des ingrédients actifs
• A01N 35/06 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un ha contenant des groupes cétone ou thiocétone faisant partie d'un cycle, p.ex. cyclohexanone, quinone; Leurs dérivés, p.ex. cétals
• A01N 37/10 - Acides carboxyliques aromatiques ou araliphatiques, ou leurs thio-analogues; Leurs dérivés
• A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant le groupe —CO—N, p.ex. amides ou imides d'acide carboxylique; Leurs thio-analogues
• A01N 37/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant le groupe —CO—N, p.ex. amides ou imides d'acide carboxylique; Leurs thio-analogues l'atome d'azote étant lié directement à un système cyclique aromatique, p.ex. anilides
• A01P 13/00 - Herbicides; Algicides

Abrégé

The devices, methods and computer programs disclosed herein refer to the automated detection of functional impairment of a device, which comprises an image capturing unit and an image recognition unit for plants, by methods of machine learning. The device is in particular a spraying device.

Classes IPC  ?

• A01M 7/00 - Adaptations ou aménagements particuliers des appareils de pulvérisation de liquides aux fins couvertes dans la présente sous-classe
• G06Q 50/02 - Agriculture; Pêche; Exploitation minière
• G06T 7/00 - Analyse d'image
• G05B 23/02 - Test ou contrôle électrique

Abrégé

The invention relates to chiral iridium hydride complexes comprising a) chiral (P,N)-ligand and b) a stabilizing enone ligand of formula (I) wherein R1150025001500250015002500150025001500250038383815003861414-aryl, which may be substituted as further defined in the specification, R1a16166 -alkylcarbonyl, or R1aand R1form together with the carbon atom to which R1ais attached and the carbonyl group to which R15757161500150015001500500-haloalkoxy, R2150015001500150038383815003861414-aryl, which may be substituted as further defined in the specification, and the arrow indicates a bond to the iridium atom, as well as to a process for preparing optically active 4-substituted 1,2,3,4-tetrahydroquinolines by enantioselective hydrogenation of the corresponding 4-substituted 1,2-dihydroquinolines in presence of such chiral iridium hydride complex.

Classes IPC  ?

• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 de la classification périodique
• C07D 215/08 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle avec l'atome d'azote du cycle acylé

Abrégé

Provided is the use of a polypeptide with calcium indicator activity which comprises an amino acid sequence represented by SEQ ID NO. 1, or an amino acid sequence which has at least 80% sequence identity thereto, for identifying transmembrane pore formation capability of a target polypeptide, especially an insecticidal protein, in a cellular assay.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• C07K 14/435 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The present invention relates to regimens for the treatment of angiogenic eye disorders such as nAMD, DR and DME characterized by high doses of aflibercept extended periods between doses.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 27/02 - Agents ophtalmiques
• C07K 14/71 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des régulateurs de croissance

Produits et services

Pharmaceutical preparations for the treatment of soil-transmitted helminthiasis and onchocerciasis; pharmaceutical preparations, namely althelmintic agents.

Produits et services

Pharmaceutical preparations for the treatment of soil-transmitted helminthiasis and onchocerciasis; pharmaceutical preparations, namely althelmintic agents.

Produits et services

Pharmaceutical preparations for the treatment of soil-transmitted helminthiasis and onchocerciasis; pharmaceutical preparations, namely althelmintic agents.

Produits et services

Software used for radiology activity and diagnosis; artificial intelligence software; downloadable computer software for processing, interpreting and managing data produced by putting into operation medical imaging procedures. Surgical and medical apparatus and instruments; medical devices for radiology activity and diagnosis. Providing access to medical databases; transmission and reception [transmission] of medical database information via a telecommunication network; telecommunications services for providing access to databases; provision of access to databases on computer networks; provision of access to on-line computer databases; transmission of database information via telecommunication networks; electronic transmission of messages, data and documents; all the aforesaid services being provided or related to the medical field. Design and development of software; installation of software, maintenance of software, updating of software, software as a service (SaaS) for use in the medical field; development of software application solutions; software as a service [SaaS] enabling the interpretation of images obtained in the context of medical imaging procedures; providing temporary use of online non-downloadable and/or downloadable software for processing, interpreting and managing data produced by putting into operation medical imaging procedures; scientific research; technological research; engineering services; research in the field of artificial intelligence; advice in the field of technological development; design and development of engineering products; all the aforesaid services being provided or connected with the medical field. Medical and health services; medical information; information in the field of health; information services with respect to diagnostic products for medical use; radiology activity assistance services.

Abrégé

The present invention covers furoindazole compounds of general formula (I): in which R1, R2, R3, R4, R5, R6a and R6b are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of autoimmune diseases such as multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, primary and secondary autoimmune uveitis, inflammatory disorders like endometriosis, inflammatory eye diseases, inflammatory kidney diseases, inflammatory liver diseases like non-alcoholic, alcoholic- and toxic fatty liver diseases, lung diseases like asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and metabolic and metabolic-endocrine disorders like metabolic syndrome, insulin resistance, diabetes mellitus type I and type II, and polycystic ovary syndrome (PCOS) disorders, neuropathic and inflammatory pain disorders in humans and animals. The present invention covers furoindazole compounds of general formula (I): in which R1, R2, R3, R4, R5, R6a and R6b are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of autoimmune diseases such as multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, primary and secondary autoimmune uveitis, inflammatory disorders like endometriosis, inflammatory eye diseases, inflammatory kidney diseases, inflammatory liver diseases like non-alcoholic, alcoholic- and toxic fatty liver diseases, lung diseases like asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and metabolic and metabolic-endocrine disorders like metabolic syndrome, insulin resistance, diabetes mellitus type I and type II, and polycystic ovary syndrome (PCOS) disorders, neuropathic and inflammatory pain disorders in humans and animals.

Classes IPC  ?

• C07D 491/048 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à cinq chaînons

Abrégé

Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens

Abrégé

The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals. The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

Classes IPC  ?

• C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A01N 43/653 - Triazoles-1,2,4; Triazoles-1,2,4 hydrogénés
• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
• C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
• C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles

Abrégé

Systems, methods, and computer programs disclosed herein relate to training and using a machine learning model to generate contrast-enhanced magnetic resonance images.

Classes IPC  ?

• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

A system, method, and computer program product are disclosed for a flow rate algorithm that utilizes changes in fluid pressure over a set time interval to calculate a true flow rate compared to a programmed flow rate, determine any over-delivery or under-delivery in the amount of fluid delivered over the set time interval, compensate for any determined over-delivery or under-delivery in the fluid flow rate over a subsequent set time interval, and repeat the flow rate algorithm for a series of subsequent set time intervals over the duration of a fluid injection procedure.

Classes IPC  ?

• A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
• A61M 5/142 - Perfusion sous pression, p.ex. utilisant des pompes

Abrégé

The present invention relates to the technical field of generating artificial contrast-enhanced radiological images.

Classes IPC  ?

• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p.ex. l’édition
• A61B 6/00 - Appareils pour diagnostic par radiations, p.ex. combinés avec un équipement de thérapie par radiations
• G06N 3/045 - Combinaisons de réseaux
• A61B 6/50 - spécialement adaptés à des parties du corps spécifiques; spécialement adaptés à des applications cliniques spécifiques
• G06N 3/088 - Apprentissage non supervisé, p.ex. apprentissage compétitif
• G06N 3/09 - Apprentissage supervisé
• G06N 3/096 - Apprentissage par transfert
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p.ex. pour analyser les cas antérieurs d’autres patients
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
• A61B 6/03 - Tomographes assistés par ordinateur

Abrégé

The invention relates to a system comprising at least one disposable comprising one or more wells in a body, wherein the wells are capable of acting as vessel for one or more chemical, biochemical or molecular biological reactions requiring one or more prescribed reaction temperatures according to a prescribed protocol, said body comprising a flat bottom side building a first heating surface capable of homogeneously conducting heat into the wells and a flat upper side comprising well openings sealed by means of a transparent sealing foil building a second heating surface capable of homogeneously conducting heat in the wells, said body being arranged in a rigid frame support; one or more separate tempering units TUx, each tempering unit TUx comprising at least one first temperature-controlled plates with a planar seat to conform to the flat bottom side of the disposable; transport means comprising a carrier in which the disposable is placed and a moving mechanism for moving the disposable into and/or out of the tempering unit TUx and for contacting one of the heating surfaces of the disposable with the first temperature-controlled plates; a control unit comprising one or more processors configured to activate the tempering units TUx and the transport means for the one or more chemical, biochemical, or molecular biological reactions. The solution of the present invention is particularly adapted for high throughput reactions or assay.

Classes IPC  ?

• C12Q 1/6851 - Amplification quantitative
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
• B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes ; Manipulation de matériaux à cet effet

Abrégé

A fluid mixing device for mixing a first injection fluid and a second injection fluid includes a first fluid inlet, a second fluid inlet, a mixing chamber in fluid communication with the first and second fluid inlets, and an outlet port in fluid communication with the mixing chamber. The first fluid inlet is configured to conduct the first injection fluid in a first direction and has a first redirecting surface. The second fluid inlet is configured to conduct the second injection fluid in a second direction along a different axis from the first direction and has a second redirecting surface. The mixing chamber is configured to mix the first injection fluid and the second fluid together. The mixture of the first injection fluid and the second injection fluid exits the fluid mixing device via the outlet port.

Classes IPC  ?

• A61M 39/10 - Raccords ou accouplements pour tubes
• A61M 39/00 - Tubes, raccords ou accouplements pour tubes, soupapes, voies d'accès ou similaires, spécialement adaptés pour un usage médical
• A61M 39/24 - Soupapes de retenue ou soupapes anti-retour

Produits et services

Software; Application software; both relating to agriculture and the cultivation of fruits and vegetables Providing temporary use of non-downloadable computer software; Software as a Service (SaaS); Platform as a service (PaaS); Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables Consultancy relating to horticulture; Agriculture services; Consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; Horticulture services

Produits et services

Software; Application software; both relating to agriculture and the cultivation of fruits and vegetables Providing temporary use of non-downloadable computer software; Software as a Service (SaaS); Platform as a service (PaaS); Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables Consultancy relating to horticulture; Agriculture services; Consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables.; Horticulture services

Produits et services

Software; Application software; both relating to agriculture and the cultivation of fruits and vegetables Providing temporary use of non-downloadable computer software; Software as a Service (SaaS); Platform as a service (PaaS); Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables Consultancy relating to horticulture; Agriculture services; Consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; Horticulture services

Produits et services

(1) Software; Application software; both relating to agriculture and the cultivation of fruits and vegetables. (1) Providing temporary use of non-downloadable computer software; Software as a Service (SaaS); Platform as a service (PaaS); Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables. (2) Consultancy relating to horticulture; Agriculture services; Consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; Horticulture services.

Produits et services

(1) Software; Application software; both relating to agriculture and the cultivation of fruits and vegetables. (1) Providing temporary use of non-downloadable computer software; Software as a Service (SaaS); Platform as a service (PaaS); Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables. (2) Consultancy relating to horticulture; Agriculture services; Consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; Horticulture services.

Produits et services

(1) Software; Application software; both relating to agriculture and the cultivation of fruits and vegetables. (1) Providing temporary use of non-downloadable computer software; Software as a Service (SaaS); Platform as a service (PaaS); Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; all relating to agriculture and the cultivation of fruits and vegetables. (2) Consultancy relating to horticulture; Agriculture services; Consultancy services relating to agriculture; all relating to agriculture and the cultivation of fruits and vegetables; providing information via a website in the field of agriculture and the cultivation of fruits and vegetables; Horticulture services.

Produits et services

Preparations for destroying vermin; Fungicides; Herbicides.

Abrégé

The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
• A61P 35/00 - Agents anticancéreux
• C07K 14/715 - Récepteurs; Antigènes de surface cellulaire; Déterminants de surface cellulaire pour des interférons
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer

Abrégé

The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

Classes IPC  ?

• A01N 43/80 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec des atomes d'azote et des atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle des cycles à cinq chaînons avec un atome d'azote et soit un atome d'oxygène, soit un atome de soufre, en positions 1,2
• A01N 25/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'application; Substances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles
• A01N 37/34 - Nitriles
• A01N 43/38 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à cinq chaînons condensés avec des carbocycles
• A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
• A01N 43/54 - Diazines-1,3; Diazines-1,3 hydrogénées
• A01N 43/56 - Diazoles-1,2; Diazoles-1,2 hydrogénées
• A01N 43/90 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant plusieurs hétérocycles déterminants condensés entre eux ou avec un système carbocyclique commun
• A01N 47/08 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone ne faisant pas partie d'un cycle et ne comportant pas de liaison à un atome d l'atome de carbone comportant une ou plusieurs liaisons simples à des atomes d'azote
• A01N 47/28 - Urées ou thiourées contenant les groupes N—CO—N ou N—CS—N
• A01N 57/12 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques du phosphore comportant des liaisons phosphore-oxygène ou des liaisons phosphore-soufre contenant des radicaux acycliques ou cycloaliphatiques

Abrégé

The present invention primarily relates to certain compositions (Components B) suitable for use in the field of agriculture comprising different drift retarding agents. These Components B are suitable for controlling offsite movement of (volatile) pesticide actives, in particular of herbicidal actives. The present invention further relates to kits for preparing herbicidal application mixtures (agronomic application mixtures, application compositions) comprising or consisting of two physically separate compositions in the form of Component A and Component B as defined herein. The present invention further relates to a method for producing application mixtures using said Components B or said kits. Components B of the present invention can be used (in methods to) control offsite movement and as part of kits of the present invention. Also, the present invention relates to the use of the kits of the present invention for controlling undesired vegetation and to corresponding methods.

Classes IPC  ?

• A01N 25/24 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'application; Substances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des ingrédients augmentant l'adhérence des ingrédients actifs
• A01N 25/04 - Dispersions ou gels
• A01N 35/06 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un ha contenant des groupes cétone ou thiocétone faisant partie d'un cycle, p.ex. cyclohexanone, quinone; Leurs dérivés, p.ex. cétals
• A01N 37/10 - Acides carboxyliques aromatiques ou araliphatiques, ou leurs thio-analogues; Leurs dérivés
• A01N 37/26 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant le groupe —CO—N, p.ex. amides ou imides d'acide carboxylique; Leurs thio-analogues contenant le groupe ; Leurs thio-analogues
• A01N 37/28 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un contenant le groupe —CO—N, p.ex. amides ou imides d'acide carboxylique; Leurs thio-analogues contenant le groupe ; Leurs thio-analogues
• A01P 13/00 - Herbicides; Algicides

Abrégé

A new and distinct tomato variety NUN 00327 TOP is disclosed, as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/82 - Solanaceae, p.ex. poivron, tabac, pomme de terre, tomate ou aubergine
• A01H 5/08 - Fruits

Abrégé

A new and distinct tomato variety NUN 00333 TOP is disclosed, as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/82 - Solanaceae, p.ex. poivron, tabac, pomme de terre, tomate ou aubergine
• A01H 5/08 - Fruits
• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues

Abrégé

A new and distinct plant of variety NUN 53044 CUP is disclosed as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/34 - Cucurbitaceae, p.ex. melon amer, concombre ou pastèque
• A01H 5/08 - Fruits

Abrégé

The invention is concerned with the technical area of generating synthetic medical recordings and relates to a method, a computer system, and a computer-readable storage medium comprising a computer program for identifying artifacts in synthetic medical recordings.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 7/90 - Détermination de caractéristiques de couleur
• G06N 3/02 - Réseaux neuronaux

Abrégé

A prime tube for use with a fluid injector includes a patient tube connector and a connection interface for removably connecting a distal end of the patient tube connector to a proximal end of the prime cap. The connection interface includes a first connector at the proximal end of the prime cap, and a second connector at the distal end of the patient tube connector. The prime cap is removably engageable with a prime tube housing having a sensing arrangement for sensing the presence of the prime cap and for sensing whether the prime cap is filled with air or filled with a liquid for monitoring the progress of a priming operation.

Classes IPC  ?

• A61M 39/20 - Couvercles ou bouchons d'obturation pour connecteurs ou extrémités ouvertes de tubes
• A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
• A61M 39/10 - Raccords ou accouplements pour tubes
• A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
• A61M 5/50 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour empêcher la réutilisation ou pour indiquer si le dispositif est défectueux, usagé, non stérile ou si l'on a tenté de l'utiliser

Abrégé

The present disclosure is concerned with the technical field of generation of artificial contrast-enhanced radiological images.

Classes IPC  ?

• G06V 10/774 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p.ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]; Séparation aveugle de source méthodes de Bootstrap, p.ex. "bagging” ou “boosting”
• A61K 49/10 - Composés organiques
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux

Abrégé

The present disclosure relates to the technical field of generation of synthetic medical images. The subjects of the present disclosure are a method, a computer system and a computer-readable storage medium comprising a computer program for detecting artifacts in synthetic medical images.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 7/90 - Détermination de caractéristiques de couleur
• G06T 11/00 - Génération d'images bidimensionnelles [2D]
• G06T 11/60 - Edition de figures et de texte; Combinaison de figures ou de texte

Abrégé

The following disclosure relates to the field of data analysis, in particular medical data analysis, or more particularly relates to systems, apparatuses, and methods for processing in particular medical data stored in different modalities, so-called multi-modal data. In some embodiments, the disclosure relates to similarity retrieval for input data, in particular medical input data.

Classes IPC  ?

• G06N 3/08 - Méthodes d'apprentissage
• G06V 10/74 - Appariement de motifs d’image ou de vidéo; Mesures de proximité dans les espaces de caractéristiques
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
• G06V 20/10 - Scènes terrestres

Abrégé

A new and distinct plant of variety NUN 53040 CUP is disclosed as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/34 - Cucurbitaceae, p.ex. melon amer, concombre ou pastèque
• A01H 5/08 - Fruits

Abrégé

A new and distinct lettuce variety NUN 06620 LTL is disclosed, as well as seeds and plants and heads or leaves thereof.

Classes IPC  ?

• A01H 6/14 - Asteraceae ou Compositae, p.ex. carthame, tournesol, artichaut ou laitue
• A01H 5/12 - Feuilles

Abrégé

A new and distinct tomato variety NUN 00331 TOP is disclosed, as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/82 - Solanaceae, p.ex. poivron, tabac, pomme de terre, tomate ou aubergine
• A01H 5/08 - Fruits
• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues

Abrégé

A plunger for use with a syringe includes a plunger body defining a central longitudinal axis and having a proximal end, a distal end, and a circumferential sidewall connecting the proximal end and the distal end. The plunger further includes at least one retaining member associated with and extending proximally from the plunger body. The at least one retaining member has a first end connected to the plunger body, a second end proximal to the first end and radially and resiliently deflectable relative to the first end, and at least one catch on the second end. A fluid injector system includes a piston having a plunger engagement mechanism configured for interacting with the at least one retaining element of the plunger to releasably engage the plunger for reciprocally driving the plunger within a barrel of the syringe.

Classes IPC  ?

• A61M 5/145 - Perfusion sous pression, p.ex. utilisant des pompes utilisant des réservoirs sous pression, p.ex. au moyen de pistons
• A61M 5/315 - Pistons; Tiges de piston; Guidage, blocage, ou limitation des mouvements de la tige; Accessoires disposés sur la tige pour faciliter le dosage
• A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps

Produits et services

Eye drops

Produits et services

Preparations for killing weeds and destroying vermin, insecticides, herbicides, fungicides

Produits et services

Chemicals used in agriculture, horticulture and forestry; seed preserving substances; plant growth regulating preparations; genes of seeds for agricultural production; fertilizers. Preparations for destroying vermin; Herbicides; fungicides. Agricultural seeds; Vegetable seeds.

Produits et services

Chemicals used in agriculture, horticulture and forestry; seed preserving substances; plant growth regulating preparations; genes of seeds for agricultural production; fertilizers. Preparations for destroying vermin; Herbicides; fungicides. Agricultural seeds; Vegetable seeds.

Produits et services

Chemicals used in agriculture, horticulture and forestry; seed preserving substances; plant growth regulating preparations; genes of seeds for agricultural production; fertilizers. Preparations for destroying vermin; Herbicides; fungicides. Agricultural seeds; Vegetable seeds.

Produits et services

Chemicals used in agriculture, horticulture and forestry; seed preserving substances; plant growth regulating preparations; genes of seeds for agricultural production; fertilizers. Preparations for destroying vermin; Herbicides; fungicides. Agricultural seeds; Vegetable seeds.

Abrégé

The present invention relates to novel, herbicidally active (1,4,5-trisubstituted 1H-pyrazol-3-yl)oxy-2-alkoxyalkyl acids and their derivatives of the general formula (I) and their agrochemically compatible salts, N-oxides, hydrates, and hydrates of the salts and N-oxides, to processes for preparation thereof and to the use thereof for control of broadleaved weeds and weed grasses in crops of useful plants, and for general control of broadleaved weeds and weed grasses in areas of the environment where plant growth is troublesome. The present invention relates to novel, herbicidally active (1,4,5-trisubstituted 1H-pyrazol-3-yl)oxy-2-alkoxyalkyl acids and their derivatives of the general formula (I) and their agrochemically compatible salts, N-oxides, hydrates, and hydrates of the salts and N-oxides, to processes for preparation thereof and to the use thereof for control of broadleaved weeds and weed grasses in crops of useful plants, and for general control of broadleaved weeds and weed grasses in areas of the environment where plant growth is troublesome. The derivatives of the (1,4,5-trisubstituted 1H-pyrazol-3-yl)oxy-2-alkoxyalkyl acids include in particular their esters and/or amides.

Classes IPC  ?

• C07C 59/40 - Composés non saturés
• A01N 37/06 - Acides carboxyliques non saturés ou leurs thio-analogues; Leurs dérivés
• A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
• A01N 43/60 - Diazines-1,4; Diazines-1,4 hydrogénées
• C07D 213/61 - Atomes d'halogènes ou radicaux nitro
• C07D 213/74 - Radicaux amino ou imino substitués par des radicaux hydrocarbonés ou par des radicaux hydrocarbonés substitués
• C07D 213/77 - Radicaux hydrazine
• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles

Abrégé

A new and distinct lettuce variety NUN 06623 LTL is disclosed, as well as seeds and plants and heads or leaves thereof.

Classes IPC  ?

• A01H 6/14 - Asteraceae ou Compositae, p.ex. carthame, tournesol, artichaut ou laitue
• A01H 5/12 - Feuilles

Abrégé

A new and distinct lettuce variety NUN 06832 LTL is disclosed, as well as seeds and plants and heads or leaves thereof.

Classes IPC  ?

• A01H 6/14 - Asteraceae ou Compositae, p.ex. carthame, tournesol, artichaut ou laitue
• A01H 5/12 - Feuilles
• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues

Abrégé

A new and distinct tomato variety NUN 00330 TOP is disclosed, as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/82 - Solanaceae, p.ex. poivron, tabac, pomme de terre, tomate ou aubergine
• A01H 5/08 - Fruits

Abrégé

Provided is a system for generation of artificial intelligence (Al) based automated healthcare applications that includes an Al medical device platform that comprises at least one processor in communication with a data repository system, the at least one processor configured to receive formatted data associated with a plurality of medical procedures for generation of one or more machine learning models, receive data associated with one or more regulatory guidance and approval processes, generate one or more machine learning models configured to predict one or more aspects associated with a medical procedure based on the data associated with the plurality of medical procedures and the data associated with the regulatory guidance and approval process, and deploy the one or more machine learning models to a production environment based on generating the one or more machine learning models. Methods and computer program products are also disclosed.

Classes IPC  ?

• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p.ex. l’édition
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p.ex. pour analyser les cas antérieurs d’autres patients
• G06N 20/00 - Apprentissage automatique
• G06T 11/60 - Edition de figures et de texte; Combinaison de figures ou de texte
• G06T 7/00 - Analyse d'image

Abrégé

The invention refers to a process for the preparation of pegylated adrenomedullin according to formula (I), to intermediates used therein, and the use of the intermediates for the preparation of pegylated adrenomedullin according to formula (I). The invention refers to a process for the preparation of pegylated adrenomedullin according to formula (I), to intermediates used therein, and the use of the intermediates for the preparation of pegylated adrenomedullin according to formula (I).

Classes IPC  ?

• C07D 207/416 - Pyrrolidines-2, 5 diones avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p.ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
• C07C 315/04 - Préparation de sulfones; Préparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde

Abrégé

A new and distinct watermelon variety NUN 12201 WMW is disclosed as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/34 - Cucurbitaceae, p.ex. melon amer, concombre ou pastèque
• A01H 5/08 - Fruits
• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues

Abrégé

A new and distinct watermelon variety NUN 12102 WMW is disclosed as well as seeds and plants and fruits thereof.

Classes IPC  ?

• A01H 6/34 - Cucurbitaceae, p.ex. melon amer, concombre ou pastèque
• A01H 5/08 - Fruits

Abrégé

Provided are improved herbicide tolerant Beta vulgaris, particularly improved sugar beet plants, with increased yield performance, while maintaining optimal and agronomically relevant herbicide tolerance, wherein the large and small subunits of the herbicide tolerance acetolactate synthase enzyme are optimally fitted. Further provided are markers for identifying such improved herbicide tolerant Beta vulgaris plants, as well methods for obtaining and identifying such improved herbicide tolerant Beta vulgaris plants.

Classes IPC  ?

• A01H 1/04 - Procédés de sélection
• A01H 1/00 - Procédés de modification des génotypes
• A01H 5/06 - Racines
• A01H 6/02 - Amaranthaceae or Chenopodiaceae, p.ex. betterave ou épinard

Abrégé

The present invention relates to melon plants comprising ToLCNDV-ES resistance against resistance breaking strains of ToLCNDV-ES and methods for generating such plants. A TIR-NBS-LRR gene was identified as conferring resistance.

Classes IPC  ?

• A01H 1/00 - Procédés de modification des génotypes
• A01H 1/04 - Procédés de sélection
• A01H 5/08 - Fruits
• A01H 6/34 - Cucurbitaceae, p.ex. melon amer, concombre ou pastèque

Produits et services

(1) Fungicides; herbicides; preparations for destroying vermin

Produits et services

(1) Fungicides; herbicides; insecticides; preparations for killing weeds and destroying vermin

Produits et services

Preparations for destroying vermin; Fungicides; Herbicides.

Produits et services

Preparations for destroying vermin; Fungicides; Herbicides.

Produits et services

(1) Laxatives, dietary and nutritional supplements for general health and well-being; dietary supplements for medical purposes, namely, vitamin and mineral supplements, fiber dietary supplements adapted for medical use; dietary and nutritional herbal and food supplements for the treatment of inflammatory diseases, namely inflammatory bowel diseases and inflammatory connective tissue diseases; enzyme dietary supplement; dietary fiber to aid digestion; dietary fiber for supporting regularity; stool softeners; antacids; nutritional supplement meal replacement bars for boosting energy; probiotic supplements; combined probiotic and fiber dietary supplements; hemorrhoid treatment preparations; anti-flatulent preparations.

Abrégé

The present invention relates to substituted 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines of the general formula (I) or salts thereof, The present invention relates to substituted 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines of the general formula (I) or salts thereof, The present invention relates to substituted 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines of the general formula (I) or salts thereof, where the radicals in the general formula (I) correspond to the definitions given in the description, and to their use as herbicides, in particular for controlling weed grasses and/or broad-leaved weeds in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.

Classes IPC  ?

• A01N 43/90 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant plusieurs hétérocycles déterminants condensés entre eux ou avec un système carbocyclique commun
• A01N 55/08 - Biocides, produits repoussant ou attirant les animaux nuisibles ou régulateurs de croissance des végétaux, contenant des composés organiques comportant des éléments autres que le carbone, l'hydrogène, les halogènes, l'oxygène, l'azote et le soufre contenant du bore
• A01P 13/00 - Herbicides; Algicides
• A01P 21/00 - Régulateurs de croissance des végétaux
• C07D 513/04 - Systèmes condensés en ortho
• C07F 5/02 - Composés du bore
• C07F 5/05 - Composés cycliques ayant au moins un cycle comportant le bore mais sans carbone dans le cycle

Abrégé

* combinations of: component A: one or more 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (A1) or (A2) as defined herein, or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; component B: anti-Programmed Cell Death Protein 1 (also referred to as “PD-1” or “CD279” (cluster of differentiation 279)) antibody (anti-PD-1 mAb) as defined herein; in which optionally some or all of the components are in the form of a pharmaceutical formulation which is ready for use to be administered simultaneously, concurrently, separately or sequentially; independently of one another by the oral, intravenous, topical, local installations, intraperitoneal or nasal route; * combinations of: component A: one or more 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (A1) or (A2) as defined herein, or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; component B: anti-Programmed Cell Death Protein 1 (also referred to as “PD-1” or “CD279” (cluster of differentiation 279)) antibody (anti-PD-1 mAb) as defined herein; in which optionally some or all of the components are in the form of a pharmaceutical formulation which is ready for use to be administered simultaneously, concurrently, separately or sequentially; independently of one another by the oral, intravenous, topical, local installations, intraperitoneal or nasal route; * use of such combinations for the preparation of a medicament for the treatment or prophylaxis of a cancer; and * combinations of: component A: one or more 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (A1) or (A2) as defined herein, or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; component B: anti-Programmed Cell Death Protein 1 (also referred to as “PD-1” or “CD279” (cluster of differentiation 279)) antibody (anti-PD-1 mAb) as defined herein; in which optionally some or all of the components are in the form of a pharmaceutical formulation which is ready for use to be administered simultaneously, concurrently, separately or sequentially; independently of one another by the oral, intravenous, topical, local installations, intraperitoneal or nasal route; * use of such combinations for the preparation of a medicament for the treatment or prophylaxis of a cancer; and * a kit comprising such a combination.

Classes IPC  ?

• A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to new manganese (Mn2+) chelate compounds, to methods of preparing said compounds, to the use of said compounds as contrast agents in diagnostic imaging such as magnetic resonance imaging (MRI) and to their use in a mammalian body.

Classes IPC  ?

• C07D 498/08 - Systèmes pontés
• A61K 49/10 - Composés organiques
• C07F 13/00 - Composés contenant des éléments des groupes 7 ou 17 de la classification périodique
• C07F 15/02 - Composés du fer
• C07H 23/00 - Composés contenant du bore, du silicium ou un métal, p.ex. chélates, vitamine B12

Produits et services

Vitamins; dietary supplements; nutritional supplements

Produits et services

Vitamins; dietary supplements; nutritional supplements

Produits et services

Vitamins; dietary supplements; nutritional supplements

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

Vitamins; dietary supplements; nutritional supplements

Produits et services

Vitamins; dietary supplements; nutritional supplements

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

(1) Vitamins; dietary supplements; nutritional supplements;

Produits et services

Vitamins; dietary supplements; nutritional supplements

Produits et services

Vitamins; dietary supplements; nutritional supplements

Produits et services

vitamins; dietary supplements; nutritional supplements

Produits et services

Vitamins; dietary supplements; nutritional supplements

Abrégé

The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also to the preparation of the enantiomer (Ia) by racemate resolution using chiral substituted tartaric acid esters of the general formulae (IIIa) and (IIIb) The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also to the preparation of the enantiomer (Ia) by racemate resolution using chiral substituted tartaric acid esters of the general formulae (IIIa) and (IIIb) The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also to the preparation of the enantiomer (Ia) by racemate resolution using chiral substituted tartaric acid esters of the general formulae (IIIa) and (IIIb) where Ar represents a substituted or unsubstituted aromatic or heteroaromatic radical.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho

Abrégé

A syringe including a proximal end, a distal end, and a cylindrical sidewall extending between the proximal end and the distal end, wherein the distal end comprises a conical distal end wall and a fluid nozzle at a distal end of the conical distal end wall; a cylindrical load bearing wall extending axially from the cylindrical sidewall past a proximal end of the conical distal end wall; and a plurality of radial ribs positioned around a periphery of the conical distal end wall, wherein a longitudinal axis of the plurality of radial ribs extends radially inward from the cylindrical load bearing wall towards the fluid nozzle over at least a portion of the conical distal end wall.

Classes IPC  ?

• A61M 5/31 - Seringues - Parties constitutives
• A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras

Produits et services

Seeds Chemical preparations for the treatment of seeds Insecticides; herbicides; fungicides; preparations for destroying vermin Agricultural research Agricultural services; agricultural consultancy