Abstract

The present invention relates to a fast-acting complex tablet containing dutasteride and tadalafil and, more specifically, to a fast-acting complex tablet composed of a first granule composition containing dutasteride as an active ingredient and a second granule composition containing tadalafil as an active ingredient, wherein the first granule composition contains, besides dutasteride, macroleol-15-hydroxystearate, linoleyl macrogol-6-glyceride, hypromellose acetate succinate, and colloidal silicon dioxide, and wherein the second granule composition contains, besides tadalafil, low-substituted hydroxypropyl cellulose, mannitol, and a disintegrant comprising microcrystalline cellulose and dibasic potassium phosphate.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

Abstract

Provided are a tablet free of a metal-containing lubricant and a preparation method therefor, the tablet containing: a tenofovir disoproxil free base as a pharmaceutically active ingredient; and one or more metal-free lubricants selected from the group consisting of glyceryl behenate, hydrogenated castor oil, a sucrose fatty acid ester, hardened vegetable oil, stearic acid, and polyethylene glycol.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

Abstract

The present invention provides a method for purifying fluvoxamine free base, comprising the conversion of crude fluvoxamine free base into fluvoxamine tartrate. In addition, the present invention provides a method for preparing fluvoxamine maleate using the purification method.

IPC Classes  ?

• C07C 251/58 - Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
• C07C 249/12 - Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reactions not involving the formation of oxyimino groups
• C07C 249/14 - SeparationPurificationStabilisationUse of additives

Abstract

The present invention provides novel anhydrous aripiprazole crystals, and more specifically anhydrous aripiprazole crystals having a powder X-ray diffraction spectrum having peaks at 7.6, 8.0, 13.4, 13.8, 20.4, 22.1, 22.5 and 24.1 °2θ(± 0.2°), and the present invention also provides a production method for same. The anhydrous aripiprazole crystals obtained according to the production method of the present invention do not exhibit changes in crystal form by maintaining an inherent melting point (melting point of from 148-149°C) which is unchanged even under accelerated conditions. Also, because the hygroscopic properties are very low and the light stability is outstanding, the invention can efficiently be made into a preparation.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Provided is a process for preparing tolterodine or its salt, which comprises: (a) reacting 2-[3-(p-nitrobenzenesulfonyloxy)-1-phenylpropyl]-4-methyl-(p-nitrobenzenesulfonyloxy or p-toluenesulfonyloxy)benzene with diisopropylamine to obtain 2-[3-(N,N-diisopropylamino)-1-phenylpropyl]-4-methyl-(p-nitrobenzenesulfonyloxy or p-toluenesulfonyloxy)benzene; and (b) deprotecting 2-[3-(N,N-diisopropylamino)-1-phenylpropyl]-4-methyl-(p-nitrobenzenesulfonyloxy or p-toluenesulfonyloxy)benzene in the presence of a base.

IPC Classes  ?

• C07C 215/56 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups