The invention relates to an aqueous parenteral pharmaceutical composition comprising:
a) 0.96-2.60% w/v of bilastine, or a pharmaceutically acceptable salt or solvate thereof,
b) 10-30% w/v of a β-cyclodextrin selected from unmodified β-cyclodextrin, C1-C6 alkyl-β-cyclodextrin, C1-C6 hydroxyalkyl β-cyclodextrin, C1-C6 carboxyalkyl-β-cyclodextrin, carbonyl-β-cyclodextrin, C1-C6 sulfoalkylether β-cyclodextrin and mixtures thereof,
wherein the pH value of the composition is between 3.0 and 7.2, both lower and upper limits of the range included and wherein parenteral is selected from intravenous or intramuscular;
and its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases and allergic symptoms; particularly when immediate action is required.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 9/00 - Medicinal preparations characterised by special physical form
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth and dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals for the prevention and treatment of vitamin D deficiency, medical and veterinary preparations for the prevention and treatment of vitamin D deficiency; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use for the prevention and treatment of vitamin D deficiency, food for babies; dietary supplements for human beings and animals for the prevention and treatment of vitamin D deficiency; Plasters, materials for dressings; Material for stopping teeth and dental wax.
The invention relates to an aqueous parenteral pharmaceutical composition comprising: a) 0.96-2.60% w/v of bilastine, or a pharmaceutically acceptable salt or solvate thereof, b) 10-30% w/v of a β-cyclodextrin selected from unmodified β-cyclodextrin, C1-C6 alkyl-β-cyclodextrin, C1-C6 hydroxyalkyl β-cyclodextrin, C1-C6 carboxyalkyl-β- cyclodextrin, carbonyl-β-cyclodextrin, C1-C6 sulfoalkylether β-cyclodextrin and mixtures thereof, wherein the pH value of the composition is between 3.0 and 7.2, both lower and upper limits of the range included and wherein parenteral is selected from intravenous or intramuscular; and its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases and allergic symptoms; particularly when immediate action is required.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
The invention relates to an aqueous pharmaceutical composition comprising:
a) bilastine, or a pharmaceutically acceptable salt or solvate thereof,
b) benzalkonium chloride, in combination with at least one further preservative selected from the group comprising phenylethyl alcohol, benzyl alcohol, sodium benzoate, chlorbutanol, phenoxyethanol, cetrimide and 2-(ethylmercuriomercapto)benzoic acid sodium salt,
c) a suspending agent, and
d) 2-hydroxypropyl-β-cyclodextrin;
wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5.
The invention relates to an aqueous pharmaceutical composition comprising:
a) bilastine, or a pharmaceutically acceptable salt or solvate thereof,
b) benzalkonium chloride, in combination with at least one further preservative selected from the group comprising phenylethyl alcohol, benzyl alcohol, sodium benzoate, chlorbutanol, phenoxyethanol, cetrimide and 2-(ethylmercuriomercapto)benzoic acid sodium salt,
c) a suspending agent, and
d) 2-hydroxypropyl-β-cyclodextrin;
wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5.
The invention also relates to said compositions for use in the treatment and/or prevention of a disorder or disease susceptible to amelioration by antagonism of H1 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration.
The invention relates to an aqueous pharmaceutical composition comprising:
a) bilastine, or a pharmaceutically acceptable salt or solvate thereof,
b) benzalkonium chloride, in combination with at least one further preservative selected from the group comprising phenylethyl alcohol, benzyl alcohol, sodium benzoate, chlorbutanol, phenoxyethanol, cetrimide and 2-(ethylmercuriomercapto)benzoic acid sodium salt,
c) a suspending agent, and
d) 2-hydroxypropyl-β-cyclodextrin;
wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5.
The invention also relates to said compositions for use in the treatment and/or prevention of a disorder or disease susceptible to amelioration by antagonism of H1 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration.
The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/569 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone substituted in position 17 alpha, e.g. ethisterone
A61K 9/00 - Medicinal preparations characterised by special physical form
The present invention relates to an immediate-release oral pharmaceutical composition for use in the prevention and/or treatment of a disease or condition caused by vitamin D deficiency. The invention also relates to a method for increasing and/or maintaining the serum levels of 25-hydroxy vitamin D in a subject to a value equal to or above 20 ng/mL which comprises the administration to said subject of an immediate- release oral composition. The composition of the invention comprises from 0.050 to 0.175 mg of 25-hydroxy vitamin D3 per dosage unit and each dosage unit is for administration following a dosage regime of at least once per week wherein the dosage regime is maintained for a period of at least 1 month. The invention further relates to a method of adapting the dosage regime.
A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
The present invention relates to an immediate-release oral pharmaceutical composition for use in the prevention and/or treatment of a disease or condition caused by vitamin D deficiency. The invention also relates to a method for increasing and/or maintaining the serum levels of 25-hydroxy vitamin D in a subject to a value equal to or above 20 ng/mL which comprises the administration to said subject of an immediate- release oral composition. The composition of the invention comprises from 0.050 to 0.175 mg of 25-hydroxy vitamin D3 per dosage unit and each dosage unit is for administration following a dosage regime of at least once per week wherein the dosage regime is maintained for a period of at least 1 month. The invention further relates to a method of adapting the dosage regime.
A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
The invention relates to new intermediates in the synthesis of Eldecalcitol and to processes for the preparation of said intermediates and of Eldecalcitol.
C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations, Medicinal preparations and Veterinary preparations for use in the following fields: Prevention and treatment of vitamin D deficiency and osteoporosis.
The present invention relates to a multi-layer oral pharmaceutical composition comprising a matrix core, comprising a decongestant and a combination of at least two cellulose derivatives, a first layer comprising a cellulose derivative and an optional second layer comprising bilastine. The present invention provides an oral dosage form comprising a decongestant drug and bilastine with a reproducible profile characterized by a controlled release of the decongestant over a period in excess of twelve hours and preferably at least 16 hours and an immediate release of bilastine after oral administration. The invention further contemplates medical uses thereof.
A61K 9/24 - Layered or laminated unitary dosage forms
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
The invention relates to compounds of formula (I):
The invention relates to compounds of formula (I):
The invention relates to compounds of formula (I):
or pharmaceutically acceptable sails or solvates thereof, to pharmaceutical compositions comprising them and to their use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
16.
Process and intermediates for the preparation of bilastine
The invention relates to a process for preparing a compound of (III)
which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof
Compounds of formula (III) are key intermediates in the synthesis of Bilastine.
C07C 67/42 - Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester by oxidation of secondary alcohols or ketones
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07C 51/09 - Preparation of carboxylic acids or their salts, halides, or anhydrides from carboxylic acid esters or lactones
C07C 67/00 - Preparation of carboxylic acid esters
17.
Aqueous compositions comprising bilastine and mometasone
wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5, and wherein the content of 2-hydroxypropyl-β-cyclodextrin is less than 8.5% by weight.
1 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration.
The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
The invention relates to an aqueous ophthalmic pharmaceutical composition comprising:
a) at least 0.4% w/v of bilastine, of formula
The invention relates to an aqueous ophthalmic pharmaceutical composition comprising:
a) at least 0.4% w/v of bilastine, of formula
or a pharmaceutically acceptable salt or solvate thereof, wherein the bilastine salt or solvate thereof is completely dissolved in the pharmaceutical composition;
b) at least one β-cyclodextrin; and
c) at least one pharmaceutically acceptable water-soluble gelling agent; and wherein the pH is comprised between 4 and 9.
and its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention relates to the treatment and/or prevention of allergic conjunctivitis.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
The invention relates to new intermediates in the synthesis of Eldecalcitol and to processes for the preparation of said intermediates and of Eldecalcitol.
11 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration. The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
21.
PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS
The invention relates to compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, to pharmaceutical compositions comprising them and to their use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor.
The invention relates to a process for preparing a compound of (III) wherein X is a leaving group; and R1166 alkyl; which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof Compounds of formula (III) are key intermediates in the synthesis of Bilastine.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
The invention relates to compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, to pharmaceutical compositions comprising them and to their use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
The present invention relates to a formulation comprising hidrosmin characterized by a modified release rate suitable for once-daily administration.The use of said composition in the prevention or treatment of a disease selected from chronic venous insufficiency, varicose veins, hemorrhoids, edema,metabolic syndrome,non-alcoholic fatty liver disease and diabetic nephropathy is also provided.
A61K 31/00 - Medicinal preparations containing organic active ingredients
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 9/14 - VasoprotectivesAntihaemorrhoidalsDrugs for varicose therapyCapillary stabilisers
A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
26.
AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE
The invention relates to an aqueous pharmaceutical composition comprising: a) bilastine or a pharmaceutically acceptable salt or solvate thereof, b) mometasone, or a pharmaceutically acceptable derivative thereof, c) a suspending agent, and d) 2-hydroxypropyl-3-cyclodextrin; wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5, and wherein the content of 2-hydroxypropyl-β-cyclodextrin is less than 8.5% by weight. The invention also relates to said compositions for use in the treatment and/or prevention of a disorder or disease susceptible to amelioration by antagonism of Hi histamine receptor and/or of a corticosteroid-responsive disease through nasal administration. The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Veterinary and sanitary preparations, chemical pharmaceuticals and pharmaceuticals; Medicines for human purposes; Dietetic food and substances adapted for medical use; Baby food; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides, nutritional supplements for human beings.
05 - Pharmaceutical, veterinary and sanitary products
31 - Agricultural products; live animals
Goods & Services
Pharmaceutical preparations for medical and veterinary use; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Food supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides. Raw and unprocessed agricultural, aquacultural, horticultural and forestry products; Raw and unprocessed grains and seeds; Fresh fruits and vegetables, fresh herbs; Natural plants and flowers; Bulbs, seedlings and seeds for planting; Live animals; Foodstuffs and beverages for animals; Malt.
Orthopaedic soles; Orthopaedic insoles; Orthopedic soles; Heel pads for orthopaedic use; Orthopaedic heelpieces; Orthopaedic soles and insoles for controlling and cushioning ground vibrations and shock waves; Thin orthopaedic soles for insertion between hygiene insoles and footwear soles, or between orthopaedic insoles and soles of footwear.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals, veterinary preparations and sanitary pharmaceuticals; Dietetic substances adapted for medical use; plasters; Bandaging materials; Material for stopping teeth; Disinfectants; Preparations for destroying weeds and vermin.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals, veterinary preparations and sanitary pharmaceuticals; Dietetic substances adapted for medical use; plasters; Bandaging materials; Material for stopping teeth; Disinfectants; Preparations for destroying weeds and vermin.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.
The invention relates to a cocrystal comprising a) at least bilastine and, b) at least a cocrystal forming compound selected from the group consisting of glutaric acid, adipic acid, sorbic acid, succinic acid, benzoic acid, 4-aminobenzoic acid, L-malic acid, resorcinol, methyl 4-hydroxy benzoate and N-(4- hydroxyphenyl)acetamide and mixtures thereof, or a solvate thereof. The invention further relates to methods for obtaining said cocrystals and to their use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention also relates to a method for increase the aqueous solubility of the above compounds of formula (I).
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
The invention relates to a stable supersaturatedaqueous solution comprising bilastine and an selected from glutaric acid, citric acid, α-cetoglutaric acid, tartaric acid, acetic acid, propionic acid and mixtures thereofand to its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention also relates to the use of the above organic carboxylic acids to increase the aqueous solubility of bilastine.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical, veterinary and sanitary products; dietetic
substances for medical use; food for babies; plasters,
material for dressings; material for dental fillings and
dental impressions; disinfectants; products for destroying
vermin; fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Pharmaceutical and veterinary preparations for the prevention and treatment of vitamin D deficiency and osteoporosis; dietetic substances adapted for medical use namely nutritional supplements for general health and well-being, calcium supplements, vitamin supplements; baby food; disinfectants namely all-purpose disinfectants, disinfectants for medical instruments; preparations for destroying vermin; fungicides; herbicides
(2) Pharmaceutical and veterinary preparations for the prevention and treatment of vitamin D deficiency and osteoporosis
The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.
The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases.
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use;
cleaning, polishing, degreasing and abrasive preparations;
soaps; perfumery, essential oils, cosmetics, hair lotions;
dentifrices. Pharmaceutical and veterinary products; sanitary products
for medical purposes; dietetic substances for medical use,
food for babies; plasters, material for dressings; material
for dental fillings and for dental impressions;
disinfectants; products for destroying vermin; fungicides,
herbicides. Surgical, medical, dental and veterinary apparatus and
instruments, artificial limbs, eyes and teeth; orthopedic
articles; suture materials.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
Business management; wholesaling via global telematic networks, mail order, catalogue order or telephone orders, relating to pharmaceutical preparations, dietetic food, dietary supplements and cosmetics; Sales promotion for others relating to the pharmaceutical sector, the production of dietetic food, dietary supplements and the cosmetics industry.
orthopaedic soles; orthopaedic inner soles; orthopaedic heelpieces and heel reinforcements; ground vibration and shock waves controlling and shock absorbing orthopaedic soles and inner soles, namely, a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole; and heelpieces for shoes and heel reinforcements, namely, heel inserts, all used in all type of shoes for orthopaedic purpose soles, inner soles, heelpieces and heel reinforcements; ground vibration and shock waves controlling and shock absorbing soles, inner soles, namely, a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole; and heelpieces for shoes and heel reinforcements, namely, heel inserts, all used in all type of shoes for sport activites purpose
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical preparations, other than for use in the dental sector, and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides. Meat, fish, poultry and game; Meat extracts; Preserved, frozen, dried and cooked fruits and vegetables; Jellies, jams, compotes; Eggs; Milk and milk products; Edible oils and fats. Coffee, tea, cocoa and artificial coffee; Rice; Tapioca and sago; Flour and preparations made from cereals; Bread, pastry and confectionery; Ices; Sugar, honey, treacle; Yeast, baking-powder; Salt; Mustard; Vinegar, sauces (condiments); Spices; Ice.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
(1) Soles for footwear, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, heelpieces for shoes and heel reinforcements, namely heel inserts; ground vibration and shock waves controlling and shock absorbing soles for footwear, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, and heelpieces for shoes and heel reinforcements, namely heel inserts; ground vibration and shock waves controlling and shock absorbing soles, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, and heelpieces and heel reinforcements, namely heel inserts, all used in all types of shoes, for sport activities; ground vibration and shock waves controlling and shock absorbing soles, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, and heelpieces and heel reinforcements, namely heel inserts, all used in all types of shoes, for medical and orthopaedic purpose.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Bleaching preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations; Soaps; Perfumery, essential oils, cosmetics, hair lotions; Dentifrices. Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides,Herbicides, medicated beverages.
65.
DIPHENYL-AMINE DERIVATIVES: USES, PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS
The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
C07C 211/27 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
C07C 211/29 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
C07C 217/58 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
C07C 255/58 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
C07D 233/58 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
C07D 235/08 - Radicals containing only hydrogen and carbon atoms
C07D 473/16 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
C07D 473/34 - Nitrogen atom attached in position 6, e.g. adenine
66.
FLUFENOXINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF AMILOYD PATHOLOGIES
The present invention is directed to a compound of formula (I) for use in a method to treat or ameliorate amyloid or tau pathologies, such as Alzheimer's disease, or symptoms thereof. The invention is also directed to new compounds of formula (I), of subformula (II), (III), (IV), or (V).
C07D 211/22 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by oxygen atoms
C07D 211/24 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by sulfur atoms to which a second hetero atom is attached
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/4462 - Non-condensed piperidines, e.g. piperocaine only substituted in position 3
A61K 31/4465 - Non-condensed piperidines, e.g. piperocaine only substituted in position 4
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations; sanitary preparations for
medical purposes; dietetic substances for medical use, food
for babies; plasters, materials for dressings; material for
stopping teeth, dental wax; disinfectants; preparations for
destroying vermin; fungicides, herbicides.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; Cleaning-, polishing, scouring- and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
32 - Beers; non-alcoholic beverages
Goods & Services
Bleaching preparations and other substances for laundry use; Cleaning-, polishing, scouring- and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and cereal preparations, bread, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice. Beers; mineral and aerated waters and other non-alcoholic drinks; fruit drinks and fruit juices; syrups and other preparations for making beverages.
17 - Rubber and plastic; packing and insulating materials
Goods & Services
Rubber, gutta-percha, gum, elastic gum, balata and
substitutes, objects made thereof not included in other
classes; sheets, plates and rods of plastic (semi-finished
goods); weatherstripping, caulking and insulating materials;
all aforementioned products suitable for shock, wave,
vibration, sound absorption.
72.
5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES
The invention relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in the preparation of a medicament for the treatment of an acute or chronic inflammatory disease, by inhibiting the production of at least one pro-inflammatory cytokine selected from TNF-alpha and IFN-gamma, or by inmunomodulating the IL-8 chemokine and/or the IL-10 regulatory cytokine. The invention also relates to novel compounds of formula (I') or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, as well as a pharmaceutical composition comprising said compound.
05 - Pharmaceutical, veterinary and sanitary products
30 - Basic staples, tea, coffee, baked goods and confectionery
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle, yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice. Medical services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.
74.
WEIGHT MANAGEMENT dietline high protein.low calory
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Bleaching preparations and other substances for laundry use; Cleaning-, polishing, scouring- and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Medical services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Préparations pour blanchir et autres substances pour
lessiver; préparations pour nettoyer, polir, dégraisser et
abraser (préparations abrasives); savons; parfumerie; huiles
essentielles, cosmétiques, lotions pour les cheveux;
dentifrices. Produits pharmaceutiques et vétérinaires; produits
hygiéniques pour la médecine; substances diététiques à usage
médical, aliments pour bébés; emplâtres, matériel pour
pansements; matières pour plomber les dents et pour
empreintes dentaires; désinfectants; produits pour la
destruction des animaux nuisibles; fongicides, herbicides. Viande, poisson, volaille et gibier; extraits de viande;
fruits et légumes conservés, séchés et cuits; gelées,
confitures, compotes; oeufs, lait et produits laitiers;
huiles et graisses comestibles. Café, thé, cacao, sucre, riz, tapioca, sagou, succédanés du
café; farines et préparations faites de céréales, pain,
pâtisserie et confiserie, glaces comestibles; miel, sirop de
mélasse; levure, poudre pour faire lever; sel, moutarde;
vinaigre, sauces (condiments); épices; glace.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; artificial manures and chemicals used in preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; artificial manures and chemicals used in preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.
82.
4-⏧(3-FLUOROPHENOXY)PHENYLMETHYL]PIPERIDINE METHANESULFONATE: USES, PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS
The present patent application is directed to 4-⏧(3-fluorophenoxy)phenylmethyl] piperidine methanesulfonic acid salt (formula I), its synthesis and use in the manufacture of a medicament for the treatment and/or prevention of a serotonine and/or norepinephrine mediated disease or condition. The present invention is also directed to pharmaceutical compositions comprising the same.
C07D 211/22 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by oxygen atoms
A61K 31/4465 - Non-condensed piperidines, e.g. piperocaine only substituted in position 4
A61P 25/00 - Drugs for disorders of the nervous system
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
16 - Paper, cardboard and goods made from these materials
Goods & Services
Soaps; perfumery; essential oils; cosmetics; hair lotions; dentifrices; tissues impregnated with cosmetic lotions. Sanitary preparations for medical purposes; disinfectants; tissues impregnated with pharmaceutical lotions. Tissues; paper napkins; tissues of paper for removing make-up; face towels of paper; impregnated moist paper wipes; toilet paper.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry; artificial manures and chemicals used in preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
25 - Clothing; footwear; headgear
28 - Games; toys; sports equipment
Goods & Services
Pharmaceutical, veterinary and sanitary preparations;
sanitary products for medical purposes; dietetic substances
adapted for medical use, food for babies; plasters,
materials for dressings; material for stopping teeth and
dental wax; disinfectants; preparations for destroying
vermin; fungicides; herbicides. Surgical, medical, dental and veterinary apparatus and
instruments, artificial limbs, eyes and teeth; orthopaedic
articles; orthopaedic soles; orthopaedic inner soles;
shock-absorbent orthopaedic inner soles; suture materials. Clothing, footwear, headgear; soles; inner soles;
shock-absorbent inner soles. Games, toys; gymnastic and sports articles not included in
other classes; Christmas tree ornaments and decorations.
Crystalline form 1 of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1 -piperidinyl]ethyl]-αα-dimethyl-benzen⊖eacetic acid Crystalline form 1 of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1 -piperidinyl]ethyl]-αα-dimethyl-benzen⊖eacetic acid of formula (I) is described, procedures for its preparation, pharmaceutical formulae containing crystalline form 1 and the use of crystalline form 1 to treat allergic reactions and pathological processes mediated by histamine in mammals such as man.
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Préparations pour blanchir et autres substances pour
lessiver; préparations pour nettoyer, polir, dégraisser et
abraser; savons; parfumerie, huiles essentielles,
cosmétiques, lotions pour les cheveux; dentifrices. Produits pharmaceutiques, vétérinaires et hygiéniques;
substances diététiques à usage médical, aliments pour bébés;
emplâtres, matériel pour pansements; matières pour plomber
les dents et pour empreintes dentaires; désinfectants;
produits pour la destruction des animaux nuisibles;
fongicides, herbicides. Viande, poisson, volaille et gibier; extraits de viande;
fruits et légumes conservés, séchés et cuits; gelées,
confitures, compotes; oeufs, lait et produits laitiers;
huiles et graisses comestibles. Café, thé, cacao, sucre, riz, tapioca, sagou, succédanés du
café; farines et préparations faites de céréales, pain,
pâtisserie et confiserie, glaces comestibles; miel, sirop de
mélasse; levure, poudre pour faire lever; sel, moutarde;
vinaigre, sauces (condiments); épices; glace à rafraîchir.
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved, dried and cooked fruits and vegetables; jellies, jams, fruit sauces; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved, dried and cooked fruits and vegetables; jellies, jams, fruit sauces; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; disinfectants; preparations for destroying vermin; fungicides, herbicides. Jellies, jams, fruit sauces; eggs. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
16 - Paper, cardboard and goods made from these materials
Goods & Services
Soaps; perfumery; essentials oils; Cosmetics; hair lotions; dentifrices; napkins of paper impregnated (moistened) with cosmetic preparations; napkins of paper impregnated (moistened) with make-up removal preparations. Tissues; paper serviettes; tissues of paper for removing make-up; face towels of paper; toilet paper.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical preparations made from plants in the form of ointments, creams, sticks or gels.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved, dried and cooked fruits and vegetables; jellies, jams, fruit sauces; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals used in science, agriculture, horticulture and forestry, artificial fertilizers and chemical substances for preserving foodstuffs. Perfumery, such as cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics. Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use; food for babies; plasters, materials for dressings; material for filling teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical, veterinary and sanitary preparations;
dietetic substances adapted for medical use, baby food;
plasters, materials for dressings; material for stopping
teeth and dental wax; disinfectants; preparations for
destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and
instruments, artificial limbs, eyes and teeth; orthopaedic
articles; suture materials.
