Abrégé

The present invention relates to nanostructured lipid carriers (NLC) comprising vitamin D3 compounds, pharmaceutical compositions comprising the NLCs, and to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.

Classes IPC  ?

• A61K 9/51 - Nanocapsules

Abrégé

The invention relates to microparticles comprising a solid core that comprises mesalazine and a polymeric binder, wherein the core has a particle size distribution with d50 of 20-100 µm and span lower than 2.5, and wherein the core comprises at least 75 wt% of mesalazine based on the total weight of the core. The invention also refers to a method for the manufacture of the microparticles, to a pharmaceutical composition comprising the microparticles and to the use of the microparticles in the prevention or treatment of an inflammatory bowel disease, such as ulcerative colitis or Crohn's disease.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 31/606 - Acide salicyliqueSes dérivés ayant des groupes amino
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

Produits et services

Productos farmacéuticos, preparaciones para uso médico y veterinario; preparaciones higiénicas para uso médico; alimentos y sustancias dietéticas para uso médico o veterinario, alimentos para bebés; suplementos alimenticios para personas o animales; esparadrapos, material para apósitos; materiales para empastes dentales, cera dental; desinfectantes; preparaciones para eliminar animales dañinos; fungicidas, herbicidas; productos químicos para la medicina y farmacia, sustancias, productos y preparados farmacéuticos, medicamentosos, veterinarios y curativos de todas clases, dietéticos de empleo medicinal, desinfectantes y antiparasitarios para uso humano.

Abrégé

The present invention relates to a controlled release pharmaceutical composition comprising a decongestant, an acrylate copolymer, a cellulose derivative and a crosslinked acrylic acid polymer. The present invention provides an oral dosage form exhibiting a reproducible profile characterized by a controlled release of the decongestant over a period in excess of twelve hours and preferably at least 16 hours after oral administration. The invention further contemplates medical uses thereof. The release profile of the delivery system of the invention is highly reproducible and can be administered once daily, thus improving patient compliance.

Classes IPC  ?

• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères

Abrégé

The invention relates to the compound of formula (I) or a salt or solvate thereof, to a pharmaceutical composition comprising the same and to its use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor and/or by histamine H1 receptor.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 11/06 - Antiasthmatiques
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 17/04 - Antiprurigineux
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
• A61P 27/02 - Agents ophtalmiques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles

Produits et services

Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; Adhesive plasters, Materials for dressings; Teeth filling materials, dental wax; Disinfectants; Vermin destroying preparations; Fungicides, herbicides.

Produits et services

Non-medicated cosmetics and toiletry preparations; Non-medicated dentifrices; Perfumes; Bleaching preparations and other substances for laundry use; Cleaning, polishing, and abrasive preparations. Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; Adhesive plasters, Materials for dressings; Teeth filling materials, dental wax; Disinfectants; Vermin destroying preparations; Fungicides, herbicides; Sanitary preparations for medical purposes; Adhesive tapes for medical purposes.

Abrégé

The disclosure relates to an aqueous ophthalmic pharmaceutical composition including: a) at least 0.4% w/v of bilastine, of formula The disclosure relates to an aqueous ophthalmic pharmaceutical composition including: a) at least 0.4% w/v of bilastine, of formula The disclosure relates to an aqueous ophthalmic pharmaceutical composition including: a) at least 0.4% w/v of bilastine, of formula or a pharmaceutically acceptable salt or solvate thereof, wherein the bilastine salt or solvate thereof is completely dissolved in the pharmaceutical composition; b) at least one β-cyclodextrin; and c) at least one pharmaceutically acceptable water-soluble gelling agent; and wherein the pH is comprised between 4 and 9. Use of the composition is described for the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The treatment and/or prevention of allergic conjunctivitis is described.

Classes IPC  ?

• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/40 - CyclodextrinesLeurs dérivés

Produits et services

Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth and dental wax; Disinfectants; Vermin destroying preparations; Fungicides, herbicides.

Produits et services

Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth and dental wax; Disinfectants.

Abrégé

The invention relates to an aqueous parenteral pharmaceutical composition comprising: a) 0.96-2.60% w/v of bilastine, or a pharmaceutically acceptable salt or solvate thereof, b) 10-30% w/v of a β-cyclodextrin selected from unmodified β-cyclodextrin, C1-C6 alkyl-β-cyclodextrin, C1-C6 hydroxyalkyl β-cyclodextrin, C1-C6 carboxyalkyl-β-cyclodextrin, carbonyl-β-cyclodextrin, C1-C6 sulfoalkylether β-cyclodextrin and mixtures thereof, wherein the pH value of the composition is between 3.0 and 7.2, both lower and upper limits of the range included and wherein parenteral is selected from intravenous or intramuscular; and its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases and allergic symptoms; particularly when immediate action is required.

Classes IPC  ?

• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/08 - Solutions
• A61K 47/40 - CyclodextrinesLeurs dérivés
• A61P 37/08 - Agents antiallergiques

Produits et services

Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth and dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Pharmaceuticals for the prevention and treatment of vitamin D deficiency, medical and veterinary preparations for the prevention and treatment of vitamin D deficiency; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use for the prevention and treatment of vitamin D deficiency, food for babies; dietary supplements for human beings and animals for the prevention and treatment of vitamin D deficiency; Plasters, materials for dressings; Material for stopping teeth and dental wax.

Produits et services

cosmetics dermatological pharmaceutical products; veterinary preparations for dermatological conditions

Abrégé

The invention relates to an aqueous parenteral pharmaceutical composition comprising: a) 0.96-2.60% w/v of bilastine, or a pharmaceutically acceptable salt or solvate thereof, b) 10-30% w/v of a β-cyclodextrin selected from unmodified β-cyclodextrin, C1-C6 alkyl-β-cyclodextrin, C1-C6 hydroxyalkyl β-cyclodextrin, C1-C6 carboxyalkyl-β- cyclodextrin, carbonyl-β-cyclodextrin, C1-C6 sulfoalkylether β-cyclodextrin and mixtures thereof, wherein the pH value of the composition is between 3.0 and 7.2, both lower and upper limits of the range included and wherein parenteral is selected from intravenous or intramuscular; and its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases and allergic symptoms; particularly when immediate action is required.

Classes IPC  ?

• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 9/08 - Solutions
• A61K 47/40 - CyclodextrinesLeurs dérivés
• A61P 37/08 - Agents antiallergiques

Abrégé

The invention relates to an aqueous parenteral pharmaceutical composition comprising: a) 0.96-2.60%whi ofbilasrinc, or a pharmaceutically acceptable salt or solvate thereof, b) 10-30% wA’of a p-cyclodextrin selected from unmodified p-cyclodcxtrin, C1-C6 alkyl-P-cyclodcxtrin, CI-C6 hydroxyalkyl p-cyclodcxtrin. CI-C6 carboxyalkyl-p- cyclodcxtrin, carbouyl-p-cyclodextrin, ClC6 snlfoalkylethcrp-cyclodcxtriii andmixtures thereof, whereinthe pH value of tire compositionisbctwccn3.Q and7.2.bothlower and upper limits of the range included and whereinparenteral is selectedfrom intravenous or intramuscular; andits usein the treatment and/ orpreventionofconditions mediatedbyIIIhistamine receptor,suchas allergic disorders or diseases andallergic symptoms;particularly when immediate actionis required.

Classes IPC  ?

• A61K 9/08 - Solutions
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 47/40 - CyclodextrinesLeurs dérivés
• A61P 37/08 - Agents antiallergiques

Abrégé

The invention relates to an aqueous pharmaceutical composition comprising: a) bilastine, or a pharmaceutically acceptable salt or solvate thereof, b) benzalkonium chloride, in combination with at least one further preservative selected from the group comprising phenylethyl alcohol, benzyl alcohol, sodium benzoate, chlorbutanol, phenoxyethanol, cetrimide and 2-(ethylmercuriomercapto)benzoic acid sodium salt, c) a suspending agent, and d) 2-hydroxypropyl-β-cyclodextrin; wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5. The invention relates to an aqueous pharmaceutical composition comprising: a) bilastine, or a pharmaceutically acceptable salt or solvate thereof, b) benzalkonium chloride, in combination with at least one further preservative selected from the group comprising phenylethyl alcohol, benzyl alcohol, sodium benzoate, chlorbutanol, phenoxyethanol, cetrimide and 2-(ethylmercuriomercapto)benzoic acid sodium salt, c) a suspending agent, and d) 2-hydroxypropyl-β-cyclodextrin; wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5. The invention also relates to said compositions for use in the treatment and/or prevention of a disorder or disease susceptible to amelioration by antagonism of H1 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration. The invention relates to an aqueous pharmaceutical composition comprising: a) bilastine, or a pharmaceutically acceptable salt or solvate thereof, b) benzalkonium chloride, in combination with at least one further preservative selected from the group comprising phenylethyl alcohol, benzyl alcohol, sodium benzoate, chlorbutanol, phenoxyethanol, cetrimide and 2-(ethylmercuriomercapto)benzoic acid sodium salt, c) a suspending agent, and d) 2-hydroxypropyl-β-cyclodextrin; wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5. The invention also relates to said compositions for use in the treatment and/or prevention of a disorder or disease susceptible to amelioration by antagonism of H1 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration. The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.

Classes IPC  ?

• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/40 - CyclodextrinesLeurs dérivés
• A61K 31/569 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone substitués en position 17 alpha, p. ex. œthistérone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

The present invention relates to an immediate-release oral pharmaceutical composition for use in the prevention and/or treatment of a disease or condition caused by vitamin D deficiency. The invention also relates to a method for increasing and/or maintaining the serum levels of 25-hydroxy vitamin D in a subject to a value equal to or above 20 ng/mL which comprises the administration to said subject of an immediate- release oral composition. The composition of the invention comprises from 0.050 to 0.175 mg of 25-hydroxy vitamin D3 per dosage unit and each dosage unit is for administration following a dosage regime of at least once per week wherein the dosage regime is maintained for a period of at least 1 month. The invention further relates to a method of adapting the dosage regime.

Classes IPC  ?

• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3
• A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
• A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

The present invention relates to an immediate-release oral pharmaceutical composition for use in the prevention and/or treatment of a disease or condition caused by vitamin D deficiency. The invention also relates to a method for increasing and/or maintaining the serum levels of 25-hydroxy vitamin D in a subject to a value equal to or above 20 ng/mL which comprises the administration to said subject of an immediate- release oral composition. The composition of the invention comprises from 0.050 to 0.175 mg of 25-hydroxy vitamin D3 per dosage unit and each dosage unit is for administration following a dosage regime of at least once per week wherein the dosage regime is maintained for a period of at least 1 month. The invention further relates to a method of adapting the dosage regime.

Classes IPC  ?

• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3
• A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
• A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

The invention relates to new intermediates in the synthesis of Eldecalcitol and to processes for the preparation of said intermediates and of Eldecalcitol.

Classes IPC  ?

• C07C 41/48 - Préparation de composés comportant des groupes
• C07C 43/188 - Éthers non saturés
• C07F 7/18 - Composés comportant une ou plusieurs liaisons C—Si ainsi qu'une ou plusieurs liaisons C—O—Si
• C07C 401/00 - Produits d'irradiation du cholestérol ou de ses dérivésDérivés de vitamine D, séco-9,10 cyclopenta[a]phénanthrène ou leurs analogues obtenus par préparation chimique sans irradiation

Produits et services

Pharmaceutical preparations, Medicinal preparations and Veterinary preparations for use in the following fields: Prevention and treatment of vitamin D deficiency and osteoporosis.

Produits et services

(1) Pharmaceutical product for the treatment of inflammatory intestinal diseases.

Produits et services

(1) Pharmaceutical product for the treatment of inflammatory intestinal diseases.

Abrégé

The present invention relates to a multi-layer oral pharmaceutical composition comprising a matrix core, comprising a decongestant and a combination of at least two cellulose derivatives, a first layer comprising a cellulose derivative and an optional second layer comprising bilastine. The present invention provides an oral dosage form comprising a decongestant drug and bilastine with a reproducible profile characterized by a controlled release of the decongestant over a period in excess of twelve hours and preferably at least 16 hours and an immediate release of bilastine after oral administration. The invention further contemplates medical uses thereof.

Classes IPC  ?

• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
• A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61P 11/02 - Agents rhinologiques, p. ex. décongestionnants
• A61P 27/14 - Décongestionnants ou antiallergiques
• A61P 37/08 - Agents antiallergiques

Abrégé

The invention relates to compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, to pharmaceutical compositions comprising them and to their use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho
• C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou

Abrégé

The invention relates to a process for preparing a compound of (III) which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof Compounds of formula (III) are key intermediates in the synthesis of Bilastine.

Classes IPC  ?

• C07C 67/42 - Préparation d'esters d'acides carboxyliques par oxydation des groupes précurseurs de la partie acide de l'ester d'alcools secondaires ou de cétones
• C07C 45/46 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par condensation par réactions de Friedel-Crafts
• C07D 235/04 - BenzimidazolesBenzimidazoles hydrogénés
• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07C 51/09 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides à partir de lactones ou d'esters d'acides carboxyliques
• C07C 67/00 - Préparation d'esters d'acides carboxyliques

Abrégé

wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5, and wherein the content of 2-hydroxypropyl-β-cyclodextrin is less than 8.5% by weight. 1 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration. The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/10 - DispersionsÉmulsions
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
• A61K 47/38 - CelluloseSes dérivés
• A61K 47/40 - CyclodextrinesLeurs dérivés

Abrégé

The invention relates to an aqueous ophthalmic pharmaceutical composition comprising: a) at least 0.4% w/v of bilastine, of formula The invention relates to an aqueous ophthalmic pharmaceutical composition comprising: a) at least 0.4% w/v of bilastine, of formula or a pharmaceutically acceptable salt or solvate thereof, wherein the bilastine salt or solvate thereof is completely dissolved in the pharmaceutical composition; b) at least one β-cyclodextrin; and c) at least one pharmaceutically acceptable water-soluble gelling agent; and wherein the pH is comprised between 4 and 9. and its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention relates to the treatment and/or prevention of allergic conjunctivitis.

Classes IPC  ?

• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/40 - CyclodextrinesLeurs dérivés

Abrégé

The invention relates to new intermediates in the synthesis of Eldecalcitol and to processes for the preparation of said intermediates and of Eldecalcitol.

Classes IPC  ?

• C07F 7/18 - Composés comportant une ou plusieurs liaisons C—Si ainsi qu'une ou plusieurs liaisons C—O—Si
• C07C 41/48 - Préparation de composés comportant des groupes
• C07C 43/178 - Éthers non saturés contenant des groupes hydroxyle ou O-métal

Abrégé

11 histamine receptor and/or of a corticosteroid-responsive disease through nasal administration. The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/08 - Solutions
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
• A61K 47/38 - CelluloseSes dérivés
• A61K 47/40 - CyclodextrinesLeurs dérivés
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit

Abrégé

The invention relates to compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, to pharmaceutical compositions comprising them and to their use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor.

Classes IPC  ?

• A61K 31/52 - Purines, p. ex. adénine
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• C07D 471/04 - Systèmes condensés en ortho

Abrégé

The invention relates to a process for preparing a compound of (III) wherein X is a leaving group; and R1166 alkyl; which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof Compounds of formula (III) are key intermediates in the synthesis of Bilastine.

Classes IPC  ?

• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07C 45/46 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par condensation par réactions de Friedel-Crafts
• C07C 49/233 - Composés non saturés comportant des groupes cétone liés à des atomes de carbone acycliques contenant des atomes d'halogène contenant des cycles aromatiques à six chaînons
• C07C 57/58 - Composés non saturés comportant des groupes carboxyle liés à des atomes de carbone acycliques contenant des atomes d'halogène contenant des cycles aromatiques à six chaînons
• C07C 51/09 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides à partir de lactones ou d'esters d'acides carboxyliques
• C07C 67/00 - Préparation d'esters d'acides carboxyliques

Abrégé

The invention relates to compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, to pharmaceutical compositions comprising them and to their use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61K 31/52 - Purines, p. ex. adénine

Abrégé

11 histamine receptor, such as allergic disorders or diseases.The invention relates to the treatment and/or prevention of allergic conjunctivitis.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/40 - CyclodextrinesLeurs dérivés
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61P 27/14 - Décongestionnants ou antiallergiques

Abrégé

The present invention relates to a formulation comprising hidrosmin characterized by a modified release rate suitable for once-daily administration.The use of said composition in the prevention or treatment of a disease selected from chronic venous insufficiency, varicose veins, hemorrhoids, edema,metabolic syndrome,non-alcoholic fatty liver disease and diabetic nephropathy is also provided.

Classes IPC  ?

• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
• A61P 9/14 - VasoprotecteursAntihémorroïdauxMédicaments pour le traitement des varicesStabilisateurs capillaires
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins

Abrégé

The invention relates to an aqueous pharmaceutical composition comprising: a) bilastine or a pharmaceutically acceptable salt or solvate thereof, b) mometasone, or a pharmaceutically acceptable derivative thereof, c) a suspending agent, and d) 2-hydroxypropyl-3-cyclodextrin; wherein the pH of the aqueous pharmaceutical composition is between 3.5 and 5.5, and wherein the content of 2-hydroxypropyl-β-cyclodextrin is less than 8.5% by weight. The invention also relates to said compositions for use in the treatment and/or prevention of a disorder or disease susceptible to amelioration by antagonism of Hi histamine receptor and/or of a corticosteroid-responsive disease through nasal administration. The invention also relates to a process for preparing the aqueous pharmaceutical composition above mentioned.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/38 - CelluloseSes dérivés
• A61K 47/40 - CyclodextrinesLeurs dérivés
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
• A61P 11/06 - Antiasthmatiques
• A61P 11/02 - Agents rhinologiques, p. ex. décongestionnants
• A61P 37/08 - Agents antiallergiques
• A61K 9/08 - Solutions

Produits et services

Veterinary and sanitary preparations, chemical pharmaceuticals and pharmaceuticals; Medicines for human purposes; Dietetic food and substances adapted for medical use; Baby food; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides, nutritional supplements for human beings.

Produits et services

Pharmaceutical preparations for medical and veterinary use; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Food supplements for human beings and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides. Raw and unprocessed agricultural, aquacultural, horticultural and forestry products; Raw and unprocessed grains and seeds; Fresh fruits and vegetables, fresh herbs; Natural plants and flowers; Bulbs, seedlings and seeds for planting; Live animals; Foodstuffs and beverages for animals; Malt.

Produits et services

Orthopaedic soles; Orthopaedic insoles; Orthopedic soles; Heel pads for orthopaedic use; Orthopaedic heelpieces; Orthopaedic soles and insoles for controlling and cushioning ground vibrations and shock waves; Thin orthopaedic soles for insertion between hygiene insoles and footwear soles, or between orthopaedic insoles and soles of footwear.

Produits et services

Pharmaceuticals, veterinary preparations and sanitary pharmaceuticals; Dietetic substances adapted for medical use; plasters; Bandaging materials; Material for stopping teeth; Disinfectants; Preparations for destroying weeds and vermin.

Produits et services

Pharmaceuticals, veterinary preparations and sanitary pharmaceuticals; Dietetic substances adapted for medical use; plasters; Bandaging materials; Material for stopping teeth; Disinfectants; Preparations for destroying weeds and vermin.

Abrégé

1 histamine receptor, such as allergic disorders or diseases.

Classes IPC  ?

• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 471/04 - Systèmes condensés en ortho

Abrégé

The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.

Classes IPC  ?

• A61K 31/047 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates ayant plusieurs groupes hydroxyle, p. ex. sorbitol
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3

Abrégé

The invention relates to a cocrystal comprising a) at least bilastine and, b) at least a cocrystal forming compound selected from the group consisting of glutaric acid, adipic acid, sorbic acid, succinic acid, benzoic acid, 4-aminobenzoic acid, L-malic acid, resorcinol, methyl 4-hydroxy benzoate and N-(4- hydroxyphenyl)acetamide and mixtures thereof, or a solvate thereof. The invention further relates to methods for obtaining said cocrystals and to their use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention also relates to a method for increase the aqueous solubility of the above compounds of formula (I).

Classes IPC  ?

• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/445 - Pipéridines non condensées, p. ex. pipérocaïne
• A61P 37/08 - Agents antiallergiques

Abrégé

The invention relates to a stable supersaturatedaqueous solution comprising bilastine and an selected from glutaric acid, citric acid, α-cetoglutaric acid, tartaric acid, acetic acid, propionic acid and mixtures thereofand to its use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention also relates to the use of the above organic carboxylic acids to increase the aqueous solubility of bilastine.

Classes IPC  ?

• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/445 - Pipéridines non condensées, p. ex. pipérocaïne
• A61P 37/08 - Agents antiallergiques

Produits et services

Pharmaceutical, veterinary and sanitary products; dietetic substances for medical use; food for babies; plasters, material for dressings; material for dental fillings and dental impressions; disinfectants; products for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical products, namely, Antihistamines

Produits et services

(1) Pharmaceutical and veterinary preparations for the prevention and treatment of vitamin D deficiency and osteoporosis; dietetic substances adapted for medical use namely nutritional supplements for general health and well-being, calcium supplements, vitamin supplements; baby food; disinfectants namely all-purpose disinfectants, disinfectants for medical instruments; preparations for destroying vermin; fungicides; herbicides (2) Pharmaceutical and veterinary preparations for the prevention and treatment of vitamin D deficiency and osteoporosis

Abrégé

The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.

Classes IPC  ?

• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3
• A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
• A61P 3/02 - Nutriments, p. ex. vitamines, minéraux

Abrégé

The present invention relates to calcifediol soft capsules, to their use in the treatment or prevention of diseases related to vitamin D deficiency, such as vitamin D deficiency, demineralization such as hypocalcemia and hypophosphatemia, renal osteodystrophy, rickets, osteoporosis, osteopenia, osteoarthritis, osteoarthrosis, osteomalacia, hypoparathyroidism, and inflammatory bowel disease, and to their process of manufacture.

Classes IPC  ?

• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat

Abrégé

The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases.

Classes IPC  ?

• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 471/04 - Systèmes condensés en ortho
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 11/06 - Antiasthmatiques

Produits et services

Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

(1) Antihistamines

Produits et services

Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Neurotonic pharmaceuticals. Paper and cardboard; Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); plastic materials forpackaging; Printers' type; Printing blocks.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs; Chemical preparations for cosmetics. Perfumery, including cosmetics, Soaps, Lotions, Essential oils, Dentifrices, Washing preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Pharmaceutical, veterinary and sanitary preparations; Dietetic substances adapted for medical use; Baby food; Plasters, materials for dressings; Materials for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices.

Produits et services

Business management; wholesaling via global telematic networks, mail order, catalogue order or telephone orders, relating to pharmaceutical preparations, dietetic food, dietary supplements and cosmetics; Sales promotion for others relating to the pharmaceutical sector, the production of dietetic food, dietary supplements and the cosmetics industry.

Produits et services

orthopaedic soles; orthopaedic inner soles; orthopaedic heelpieces and heel reinforcements; ground vibration and shock waves controlling and shock absorbing orthopaedic soles and inner soles, namely, a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole; and heelpieces for shoes and heel reinforcements, namely, heel inserts, all used in all type of shoes for orthopaedic purpose soles, inner soles, heelpieces and heel reinforcements; ground vibration and shock waves controlling and shock absorbing soles, inner soles, namely, a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole; and heelpieces for shoes and heel reinforcements, namely, heel inserts, all used in all type of shoes for sport activites purpose

Produits et services

(1) Soles for footwear, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, heelpieces for shoes and heel reinforcements, namely heel inserts; ground vibration and shock waves controlling and shock absorbing soles for footwear, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, and heelpieces for shoes and heel reinforcements, namely heel inserts; ground vibration and shock waves controlling and shock absorbing soles, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, and heelpieces and heel reinforcements, namely heel inserts, all used in all types of shoes, for sport activities; ground vibration and shock waves controlling and shock absorbing soles, inner soles, undersoles, namely a thin sole which is inserted between the sanitary sole and the footwear sole, or between the orthopaedic sole and the footwear sole, and heelpieces and heel reinforcements, namely heel inserts, all used in all types of shoes, for medical and orthopaedic purpose.

Produits et services

Bleaching preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations; Soaps; Perfumery, essential oils, cosmetics, hair lotions; Dentifrices. Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

(1) Antihistamines

Produits et services

Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides,Herbicides, medicated beverages.

Abrégé

The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.

Classes IPC  ?

• A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 31/341 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide non condensés avec un autre cycle, p. ex. ranitidine, furosémide, bufétolol, muscarine
• A61K 31/381 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à cinq chaînons
• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
• A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/52 - Purines, p. ex. adénine
• C07C 211/27 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant au moins un cycle aromatique à six chaînons ayant des groupes amino reliés au cycle aromatique à six chaînons par l'intermédiaire de chaînes carbonées saturées
• C07C 211/29 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant au moins un cycle aromatique à six chaînons le squelette carboné étant substitué de plus par des atomes d'halogène ou par des groupes nitro ou nitroso
• C07C 217/58 - Composés contenant des groupes amino et hydroxy éthérifiés liés au même squelette carboné ayant des groupes hydroxy éthérifiés liés à des atomes de carbone d'au moins un cycle aromatique à six chaînons et des groupes amino liés à des atomes de carbone acycliques ou à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du même squelette carboné avec des groupes amino reliés au cycle aromatique à six chaînons, ou au système cyclique condensé contenant ce cycle, par l'intermédiaire de chaînes carbonées qui ne sont pas substituées de plus par des atomes d'oxygène liés par des liaisons simples avec des groupes amino et le cycle aromatique à six chaînons, ou le système cyclique condensé contenant ce cycle, liés au même atome de carbone de la chaîne carbonée
• C07C 255/58 - Nitriles d'acides carboxyliques ayant des groupes cyano liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné contenant des groupes cyano et des atomes d'azote, liés par des liaisons simples et n'étant pas liés de plus à d'autres hétéro-atomes, liés au squelette carboné
• C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
• C07D 235/08 - Radicaux ne contenant que des atomes d'hydrogène et de carbone
• C07D 473/16 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'azote
• C07D 473/34 - Atome d'azote lié en position 6, p. ex. adénine

Abrégé

The present invention is directed to a compound of formula (I) for use in a method to treat or ameliorate amyloid or tau pathologies, such as Alzheimer's disease, or symptoms thereof. The invention is also directed to new compounds of formula (I), of subformula (II), (III), (IV), or (V).

Classes IPC  ?

• C07D 211/22 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes de carbone du cycle avec des radicaux hydrocarbonés, substitués par des atomes d'oxygène ou de soufre liés par des liaisons simples par des atomes d'oxygène
• C07D 211/24 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes de carbone du cycle avec des radicaux hydrocarbonés, substitués par des atomes d'oxygène ou de soufre liés par des liaisons simples par des atomes de soufre auxquels est lié un second hétéro-atome
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 409/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• A61K 31/4462 - Pipéridines non condensées, p. ex. pipérocaïne substituées uniquement en position 3
• A61K 31/4465 - Pipéridines non condensées, p. ex. pipérocaïne substituées uniquement en position 4
• A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; Artificial fertilizers and Chemical substances for preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides.

Produits et services

Pharmaceutical preparations; sanitary preparations for medical purposes; dietetic substances for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Bleaching preparations and other substances for laundry use; Cleaning-, polishing, scouring- and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.

Produits et services

Bleaching preparations and other substances for laundry use; Cleaning-, polishing, scouring- and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and cereal preparations, bread, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice. Beers; mineral and aerated waters and other non-alcoholic drinks; fruit drinks and fruit juices; syrups and other preparations for making beverages.

Produits et services

Rubber, gutta-percha, gum, elastic gum, balata and substitutes, objects made thereof not included in other classes; sheets, plates and rods of plastic (semi-finished goods); weatherstripping, caulking and insulating materials; all aforementioned products suitable for shock, wave, vibration, sound absorption.

Abrégé

The invention relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in the preparation of a medicament for the treatment of an acute or chronic inflammatory disease, by inhibiting the production of at least one pro-inflammatory cytokine selected from TNF-alpha and IFN-gamma, or by inmunomodulating the IL-8 chemokine and/or the IL-10 regulatory cytokine. The invention also relates to novel compounds of formula (I') or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, as well as a pharmaceutical composition comprising said compound.

Classes IPC  ?

• C07D 277/24 - Radicaux substitués par des atomes d'oxygène
• A61K 31/425 - Thiazoles

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle, yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice. Medical services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Produits et services

Bleaching preparations and other substances for laundry use; Cleaning-, polishing, scouring- and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Medical services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking - powder; salt, mustard; vinegar, sauces (condiments); spices; ice.

Produits et services

Préparations pour blanchir et autres substances pour lessiver; préparations pour nettoyer, polir, dégraisser et abraser (préparations abrasives); savons; parfumerie; huiles essentielles, cosmétiques, lotions pour les cheveux; dentifrices. Produits pharmaceutiques et vétérinaires; produits hygiéniques pour la médecine; substances diététiques à usage médical, aliments pour bébés; emplâtres, matériel pour pansements; matières pour plomber les dents et pour empreintes dentaires; désinfectants; produits pour la destruction des animaux nuisibles; fongicides, herbicides. Viande, poisson, volaille et gibier; extraits de viande; fruits et légumes conservés, séchés et cuits; gelées, confitures, compotes; oeufs, lait et produits laitiers; huiles et graisses comestibles. Café, thé, cacao, sucre, riz, tapioca, sagou, succédanés du café; farines et préparations faites de céréales, pain, pâtisserie et confiserie, glaces comestibles; miel, sirop de mélasse; levure, poudre pour faire lever; sel, moutarde; vinaigre, sauces (condiments); épices; glace.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; artificial manures and chemicals used in preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; artificial manures and chemicals used in preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Soaps; perfumery; essential oils; cosmetics; hair lotions; dentifrices; tissues impregnated with cosmetic lotions. Sanitary preparations for medical purposes; disinfectants; tissues impregnated with pharmaceutical lotions. Tissues; paper napkins; tissues of paper for removing make-up; face towels of paper; impregnated moist paper wipes; toilet paper.

Produits et services

Soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; frozen, preserved, dried and cooked fruits and vegetables; jellies, jams, fruit sauces; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry; artificial manures and chemicals used in preserving foodstuffs. Perfumery including cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics, bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations. Pharmaceutical, veterinary and sanitary preparations, dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical, veterinary and sanitary preparations; sanitary products for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth and dental wax; disinfectants; preparations for destroying vermin; fungicides; herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopaedic articles; orthopaedic soles; orthopaedic inner soles; shock-absorbent orthopaedic inner soles; suture materials. Clothing, footwear, headgear; soles; inner soles; shock-absorbent inner soles. Games, toys; gymnastic and sports articles not included in other classes; Christmas tree ornaments and decorations.

Produits et services

orthopedic soles; orthopedic inner soles; shock-absorbent orthopedic inner soles footwear; soles; inner soles; shock-absorbent inner soles

Produits et services

Soaps; perfumery; essentials oils; Cosmetics; hair lotions; dentifrices; napkins of paper impregnated (moistened) with cosmetic preparations; napkins of paper impregnated (moistened) with make-up removal preparations. Tissues; paper serviettes; tissues of paper for removing make-up; face towels of paper; toilet paper.

Produits et services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical preparations made from plants in the form of ointments, creams, sticks or gels.

Produits et services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Meat, fish, poultry and game; meat extracts; preserved, dried and cooked fruits and vegetables; jellies, jams, fruit sauces; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, ices; honey, treacle; yeast, baking-powder; salt, mustard; vinegar, sauces (condiments); spices; ice.

Produits et services

Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Chemicals used in science, agriculture, horticulture and forestry, artificial fertilizers and chemical substances for preserving foodstuffs. Perfumery, such as cosmetics, soaps, lotions, essential oils, dentifrices, chemical preparations for cosmetics. Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use; food for babies; plasters, materials for dressings; material for filling teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, baby food; plasters, materials for dressings; material for stopping teeth and dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopaedic articles; suture materials.

Produits et services

Chemical preparations. Hair lotions, dentifrices, chemical preparations for cosmetics. Pharmaceutical preparations.

Produits et services

Mouchoirs en papier; serviettes en papier; papier hygiénique.

Produits et services

Produits et spécialités chimico-pharmaceutiques.