Abstract

D-serine is effective for inhibiting neuron loss due to an immune response by glial cells to a brain injury. An example of a method includes artificially administering a composition including D-serine to brain cells after an injury thereto, the composition including an amount of D-serine effective to inhibit death of neurons.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Disclosed herein are methods and kits for quantifying the presence of a microorganism in a sample. Specifically, disclosed are methods for quantifying a pathogen in a sample, such as a food sample, to determine if the levels of pathogen present in the sample are within an acceptable range.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12R 1/42 - Salmonella

Abstract

A non-bonded, tape wound magnet includes a stack of disk coils, the disk coils having outer radius rd stacked on a z axis having opposing terminal ends. The disk coils include pancake-wound superconducting tape including a superconducting material and having a wound radius rsc. At least one disk coil at each opposing terminal end of the stack has overbanding positioned radially outward from the pancake wound superconducting tape. The overbanding has an elastic modulus and ultimate tensile strength at least 50% greater than the elastic modulus and ultimate tensile strength of the superconducting tape, and an electrical resistance at least 100% greater than that of the superconducting material, the overbanding having a radial dimension ro. The overbanding applies radial compression to the pancake wound superconducting tape. A method of making a magnet is also disclosed.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• H01F 41/071 - Winding coils of special form

Abstract

The present disclosure relates in some aspects to substituted ergolines, such as 14-monosubstituted and 2,14-disubstituted lysergamides, and quaternized derivatives thereof. In some aspects, the disclosure relates to methods of synthesizing the compounds, compositions containing the compounds, and methods of using the compounds, including their administration to subjects. In some aspects, features of the compounds include neuromodulatory activity, for example, activation of serotonin receptors. In some further aspects, the compounds are useful as therapeutic agents, such as anti-inflammatory agents.

IPC Classes  ?

• C07D 457/06 - Lysergic acid amides
• A61K 31/48 - Ergoline derivatives, e.g. lysergic acid, ergotamine

Abstract

Various implementations include a method of decreasing oxygen saturation levels in a patient, including securing a leg and foot of the patient to a splint having a leg supporting portion, a foot supporting portion, and an inflatable device. The leg supporting portion includes a leg support body and leg support surface. The foot supporting portion includes a foot support body and foot support surface. The inflatable device rotates the foot support surface relative to the leg support surface from a first position to a second position. The angle between a leg longitudinal axis and a foot longitudinal axis is less in the second position than in the first position. The method further includes inflating the inflatable device to rotate the foot support surface from the first position to the second position and maintaining the second position to decrease oxygen saturation levels in the patient.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Disclosed herein are a system and methods for determining an area's vulnerability to waterborne diseases and evaluating stormwater best management practices (BMPs) to mitigate vulnerabilities, according to various implementations. Generally, the disclosed system is configured to obtain data relating to a number of waterborne disease cases in a given area and corresponding socioeconomic data for the area. Based on these datasets, the disclosed system can determine a vulnerability index that is indicative of the area's vulnerability to waterborne diseases. The system can then predict how various stormwater BMPs can impact the vulnerability index (e.g., positively or negatively) to evaluate how implementing stormwater BMPs can improve the subject area's vulnerability to waterborne diseases. In some cases, the system and methods described herein may be implemented via a software tool; however, other implementations are contemplated herein.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

Various implementations described herein include methods and systems for characterizing material properties at cryogenic temperatures that are suitable for studying epoxy and metal interfaces. One implementation include a mold for forming composite samples for a pullout test. Various other implementations include a method of forming a composite sample for a pullout test.

IPC Classes  ?

• G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
• B29C 33/12 - Moulds or coresDetails thereof or accessories therefor with incorporated means for positioning inserts, e.g. labels
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process

Abstract

Metal halide perovskite crystals, composite materials that include metal halide perovskite crystals and a polymeric matrix material, devices that include metal halide perovskite crystals, and methods of forming metal halide perovskite crystals, composite materials, and devices. The devices may include optoelectronic devices, such as light-emitting diodes. The light-emitting diodes may emit red light.

IPC Classes  ?

• C07F 7/24 - Lead compounds
• C07F 1/00 - Compounds containing elements of Groups 1 or 11 of the Periodic Table
• C07F 7/00 - Compounds containing elements of Groups 4 or 14 of the Periodic Table
• H10K 85/10 - Organic polymers or oligomers
• H10K 85/60 - Organic compounds having low molecular weight
• H10K 102/10 - Transparent electrodes, e.g. using graphene

Abstract

A wearable clip system comprises a shoulder strap with a front portion comprising an upper section having two ends, wherein one end attaches to a back portion of the shoulder strap and a second end attaches to a first clip portion of a middle clip; a lower section having two ends, wherein one end attaches to a first clip portion of an end clip and a second end attaches to the first clip portion of the middle clip; and an additional strap section having two ends, wherein one end attaches to the back portion of the shoulder strap and a second end attaches to a second clip portion of the middle clip.

IPC Classes  ?

• A41C 3/12 - Component parts
• A41C 3/04 - Brassières for nursing mothers

Abstract

Described is a magnetocaloric regenerator comprising one or more materials containing cobalt, manganese and boron and optionally carbon.

IPC Classes  ?

• H01F 1/01 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials
• C22C 19/00 - Alloys based on nickel or cobalt
• C22C 19/07 - Alloys based on nickel or cobalt based on cobalt

Abstract

Described herein are processes for preparing compounds of Formula I, Formula IIa, Formula IIb, Formula IIc, and Formula IId.

IPC Classes  ?

• C07D 487/10 - Spiro-condensed systems
• C07D 205/04 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• C07D 205/12 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

Abstract

A prefilled syringe testing system may include an interface configured to fluidly couple with the cavity of the prefilled sealed container. A prefilled syringe testing system may include a vacuum pump providing a predetermined negative pressure to the interface. A prefilled syringe testing system may include a pressure gauge coupled to the interface and providing a pressure measurement indicative of leakage from the cavity.

IPC Classes  ?

• G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
• A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing

Abstract

Described herein are systems and methods for continuous metabolism of contaminants of emerging concern. An example bioreactor can include at least one screen positioned downstream in relation to the at least one adsorbent layer, wherein: the bioreactor system is configured to retain within the housing the biofilm that becomes detached from the at least one adsorbent layer, the housing is configured to receive through the inlet a flow of an influent comprising water contaminated with the at least one target contaminant, and the bioreactor system is configured to discharge an effluent from the outlet, which comprises water with a lower concentration of the contaminant compared to the influent.

IPC Classes  ?

• C02F 3/10 - PackingsFillingsGrids
• C02F 3/00 - Biological treatment of water, waste water, or sewage
• C02F 3/08 - Aerobic processes using moving contact bodies

Abstract

Bulk assemblies are provided, which may have desirable photoluminescence quantum efficiencies. The bulk assemblies may include two or more metal halides, and a wide band gap organic network. The wide band gap organic network may include organic cations. The metal halides may be disposed in the wide band gap organic network. Light emitting composite materials also are provided.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• C09K 11/74 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing arsenic, antimony or bismuth
• C09K 11/77 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing rare earth metals
• H05B 33/14 - Light sources with substantially two-dimensional radiating surfaces characterised by the chemical or physical composition or the arrangement of the electroluminescent material
• H05B 33/20 - Light sources with substantially two-dimensional radiating surfaces characterised by the chemical or physical composition or the arrangement of the material in which the electroluminescent material is embedded

Abstract

Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.

IPC Classes  ?

• G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal
• G01T 1/20 - Measuring radiation intensity with scintillation detectors

Abstract

An apparatus is provided for reel-to-reel assessment of superconducting tapes (for example, REBCO CC tape) at low temperatures (for example, less than or equal to 65K). For example, the apparatus may be a forced magnetometer. The apparatus may include one or more reels and pulleys used to move the superconducting tape into and out of a cryostat. The apparatus may also include a permanent magnet or electromagnet provided at a low temperature proximate to the tape. The magnet induces screening currents in the tape. The apparatus may also include an electric motor used to drive movement of the tape relative to the magnet. A tensionmeter may be provided to measure a tension of the tape. Alternatively, a current provided to the motor may also be measured. The apparatus may be used to measure the critical current at various positions on the superconducting tape at the low temperatures.

IPC Classes  ?

• G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids

Abstract

The present disclosure provides for a composition comprising a hydrochar, wherein the hydrochar comprises microwave-irradiated biomass. Further provided herein is a method of making the composition of claim 1, the method comprising: irradiating the biomass with microwaves under an inert atmosphere at conditions effective to yield the hydrochar. Also disclosed herein is a method of improving the quality of a soil comprising combining the soil with the composition disclosed herein.

IPC Classes  ?

• C09K 17/42 - Inorganic compounds mixed with organic active ingredients, e.g. accelerators
• C10L 9/08 - Treating solid fuels to improve their combustion by heat treatment, e.g. calcining

Abstract

Described herein are systems and methods providing online, interactive, trustworthy knowledge graphs for a specific topic (e.g., COVID-19) and search engines using such knowledge graphs. In some aspects, a method for automatically constructing knowledge graphs includes: accessing a dataset, the dataset including a plurality of articles related to a specific topic; classifying, using a first artificial intelligence (AI) model, a plurality of tables within the dataset; classifying, using a second AI model, a plurality of hierarchal metadata of the tables; and fusing, using a third AI model, the hierarchal metadata into a knowledge graph, the knowledge graph being associated with the specific topic.

IPC Classes  ?

• G06N 5/02 - Knowledge representationSymbolic representation

Abstract

For renewable energy technology to become ubiquitous, it is imperative to develop efficient oxygen evolution reaction (OER) electrocatalysts, which is challenging due to the kinetically and thermodynamically unfavorable OER mechanism. In accordance with the purpose(s) of the present disclosure, described herein are iron/nickel carbide compounds that possess unique electrochemical properties. The electrochemical performance of carbides can fine-tuned via Fe incorporation and with control, or suppression, of the growth of the oxide phase on the carbide catalytic surface.

IPC Classes  ?

• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C01B 32/90 - Carbides
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• H01M 4/90 - Selection of catalytic material

Abstract

For renewable energy technology to become ubiquitous, it is imperative to develop efficient oxygen evolution reaction (OER) electrocatalysts, which is challenging due to the kinetically and thermodynamically unfavorable OER mechanism. In accordance with the purpose(s) of the present disclosure, described herein are iron/cobalt/nickel carbide compounds that possess unique electrochemical properties.

IPC Classes  ?

• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C01B 32/90 - Carbides
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• H01M 4/90 - Selection of catalytic material

Abstract

Described and disclosed herein are embodiments of a tribometer. In some instances the tribometer comprises an actuator system composed of a monolithic biaxial load cell with an integrated sample holder, a flexure, and an amplified piezo actuator.

IPC Classes  ?

• G01N 19/02 - Measuring coefficient of friction between materials

Abstract

Molecular quantum random access memory (QRAM) devices are provided based on chirality-induced spin selectivity (CISS).

IPC Classes  ?

• G11C 11/44 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using super-conductive elements, e.g. cryotron
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect

Abstract

Described herein are articles coated with one or more polyelectrolyte complexes. The polyelectrolyte complexes have a high glass transition temperature when the coating is contacted with an aqueous medium. In one aspect, the coating has a glass transition temperature of at least 45° C. when in contact with an aqueous medium, which makes the coatings described herein as “glassy.” The coating compositions described herein are effective in reducing adhesion of organisms on the surface of the coated article, which makes the coatings an effective antifouling coating.

IPC Classes  ?

• C09D 5/16 - Anti-fouling paintsUnderwater paints
• C08F 212/08 - Styrene
• C08F 212/14 - Monomers containing only one unsaturated aliphatic radical containing one ring substituted by hetero atoms or groups containing hetero atoms
• C08F 226/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
• C08F 226/06 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
• C08G 65/40 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols from phenols and other compounds
• C08G 75/029 - Modification with organic compounds
• C08G 75/14 - Polysulfides
• C08G 75/20 - Polysulfones
• C09D 7/20 - Diluents or solvents

Abstract

The disclosure relates to a devices, systems and methods implementing desaturation protection during faults (over-current or short-circuit faults) for a power device by monitoring drain source voltage and rate of change of the drain source voltage which provides a fault response time (t0 to t2) that is shorter than the blanking time (t0 to t5) required by conventional desaturation protection methods.

IPC Classes  ?

• H03K 17/0812 - Modifications for protecting switching circuit against overcurrent or overvoltage without feedback from the output circuit to the control circuit by measures taken in the control circuit

Abstract

An example of a bottlebrush polymer has a polymer backbone and a plurality of individual brush moieties bonded to the polymer backbone. The individual brush moieties respectively include a crosslinked oxyamine moiety, a hydrophilic segment, and a surface adhesive terminal group.

IPC Classes  ?

• C08F 290/00 - Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
• C08F 290/02 - Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
• C08F 290/04 - Polymers provided for in subclasses or
• C08F 290/06 - Polymers provided for in subclass
• C08F 291/06 - Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups on to oxygen-containing macromolecules
• C08F 291/12 - Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups on to nitrogen-containing macromolecules
• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C08G 65/333 - Polymers modified by chemical after-treatment with organic compounds containing nitrogen
• C08G 65/334 - Polymers modified by chemical after-treatment with organic compounds containing sulfur
• C08G 65/336 - Polymers modified by chemical after-treatment with organic compounds containing silicon
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules

Abstract

A short-circuit protection and localization circuit for power devices includes a first subcircuit for detecting dv/dt of a power device at turn on, a second subcircuit for short-circuit fault localization and soft turn-off of the power device, the second subcircuit including a totem-pole driver having an upper switch and a lower switch, and a third subcircuit for detecting short-circuit faults based on the output (Vdip) of the first subcircuit and the output of an upper switch (Vp) of the second subcircuit. The first subcircuit outputs a voltage (Vdip) having a magnitude that is proportional to dv/dt of the power device. The third subcircuit outputs a signal (Vsto) to the second subcircuit that causes the second subcircuit to softly turn-off the power device. The second subcircuit outputs a voltage of the upper switch (Vp) and a fault-latching signal for short-circuit localization.

IPC Classes  ?

• G01R 31/52 - Testing for short-circuits, leakage current or ground faults
• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof
• G01R 19/12 - Measuring rate of change
• G01R 29/02 - Measuring characteristics of individual pulses, e.g. deviation from pulse flatness, rise time or duration
• G01R 31/26 - Testing of individual semiconductor devices

Abstract

For renewable energy technology to become ubiquitous, it is imperative to develop efficient oxygen evolution reaction (OER) electrocatalysts, which is challenging due to the kinetically and thermodynamically unfavorable OER mechanism. In accordance with the purpose(s) of the present disclosure, described herein are iron/cobalt carbide compounds. The electrochemical performance of carbides can fine-tuned via Fe incorporation and with control, or suppression, of the growth of the oxide phase on the carbide catalytic surface.

IPC Classes  ?

• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C01B 32/90 - Carbides
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• H01M 4/90 - Selection of catalytic material

Abstract

This disclosure relates to pharmaceutical compositions comprising one or more therapeutic agents selected from a SERPINE1 serine protease inhibitor, a histone acetyltransferase inhibitor, a histone deacetylase inhibitor, an insulin-like growth factor inhibitor, an anti-hypertensive agent, a topoisomerase II inhibitor, a tyrosine kinase inhibitor, an agent that downregulates growth factors or any combination thereof, and methods of treating fibrotic disorders, including keloid, pulmonary fibrosis, hepatic fibrosis, cardiac fibrosis, renal fibrosis, mediastinal fibrosis, retroperitoneal cavity fibrosis, bone marrow fibrosis, and/or scleroderma using the same. The disclosed methods can be accompanied by application of radiation and/or surgical resection. For treating keloids, the compositions can be formulated topically and do not cause systemic side effects. For treating fibrotic diseases of internal organs, the compositions can be administered systemically or delivered to the affected organs. The compositions can include two or more therapeutic agents that work synergistically, allowing lower doses of each therapeutic agent.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A method of conducting reactions utilizing a gas/liquid/plasma reactor includes the steps of providing a gas/liquid/plasma reactor, providing a liquid and a gas defining a gas/liquid interface within the gas/liquid/plasma reactor, and charging the liquid and gas inside the gas/liquid/plasma reactor. The charging includes the application of a voltage to electrodes and thereby to the liquid and gas which includes a series of voltage bursts having an outer burst pulse frequency. The bursts each include a series of voltage pulses having an inner burst pulse frequency. The electrodes can be oriented such that a plasma is propagated across the gas/liquid interface when the voltage pulses are applied. A system for conducting reactions utilizing a gas/liquid/plasma reactor is also disclosed.

IPC Classes  ?

• B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
• C01B 15/029 - Preparation from hydrogen and oxygen

Abstract

Systems and methods are provided for image reconstruction of a sample via adaptive probing of piecewise continuous surfaces. A machine learning algorithm can be employed with scanning-based measurement instruments or experimental probers to optimize the selection of probe locations for effectively scanning piecewise continuous surfaces. A limited number of initial probes may first be obtained to estimate the piecewise continuous surface. The machine learning algorithm may then be leveraged to identify any subsequent probe locations used to obtain additional data points about the piecewise continuous surface. The selection of the probe locations may be performed iteratively until sufficient data has been obtained to generate an accurate image reconstruction.

IPC Classes  ?

• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
• G06F 17/17 - Function evaluation by approximation methods, e.g. interpolation or extrapolation, smoothing or least mean square method

Abstract

The invention concerns compositions and a method for treating or delaying the onset, progression, or relapse of a cancer in a subject, the method comprising administering, optionally with radiation therapy, two or more of: a DNA-dependent protein kinase catalytic subunit (DNA-PKcs) inhibitor, a poly-ADP ribose polymerase (PARP) inhibitor, an isocitrate dehydrogenase (IDH) inhibitor, a histone acetyltransferase (HAT) inhibitor, a histone deacetylase (HDAC), inhibitor, and a DNA polymerase theta (POLθ) inhibitor. The inhibitors can be administered to the subject simultaneously, or sequentially in any order or combination.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/12 - Ketones
• A61P 35/00 - Antineoplastic agents
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir

Abstract

The disclosure relates to a devices, systems and methods implementing a delta-connected cascaded multilevel converter comprised of a plurality of U-PEBBs, each U-PEBB comprising a bi-directional and isolated ac to dc converter module using Si or SiC power semiconductor devices.

IPC Classes  ?

• H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

Organic metal halide hybrids (OMHHs) that can be used as improved materials (e.g., emitter materials) for electrically driven LEDs are provided, as well as methods of fabricating the same. The OMHHs can be highly luminescent and conductive zero-dimensional (0D) OMHHs. Efficient LEDs can include one or more of the OMHHs described herein. For example, the OMHH can be (and the LEDs can be based on) solution processed TPPcarzSbBr4 thin films and/or TPPcarzSbBr4 single crystals.

IPC Classes  ?

• H10K 85/60 - Organic compounds having low molecular weight
• C07F 9/572 - Five-membered rings
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

The present disclosure provides block copolymers, thin films including block copolymers, and methods for forming block copolymers and thin films. The block copolymers, due to self-assembly or otherwise, may include one or more regions. The one or more regions may permit a thin film including a block copolymer to be used as a nanostructured membrane.

IPC Classes  ?

• C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
• B01D 71/80 - Block polymers
• C08F 212/08 - Styrene
• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• C08F 226/06 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
• C08F 228/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a bond to sulfur or by a heterocyclic ring containing sulfur by a bond to sulfur

Abstract

Systems and methods for error reduction in three-dimensional (3D) printing are provided and can include automatically adjusting printing parameters (for example, printing speed, acceleration, extrusion rate, and/or any other parameters) in the “G-codes” for a 3D printer (for example, fused deposition modeling) to compensate for printing errors that may occur when printing is performed at a high speed. An algorithm can be used to increase printing speed while mitigating reductions in printing quality.

IPC Classes  ?

• B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes

Abstract

Extracellular vesicles (EVs) from human induced pluripotent stem cells (hiPSCs) may be produced by forming 3-D brain organoids of the hiPSCs in a dynamic bioreactor and collecting the EVs from the bioreactor. The EVs may be used for treating ischemic conditions.

IPC Classes  ?

• A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/06 - OintmentsBases therefor
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/079 - Neural cells
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

An apparatus is provided for reel-to-reel assessment of superconducting tapes (for example, REBCO CC tape) at low temperatures (for example, less than or equal to 65K). For example, the apparatus may be a force magnetometer. The apparatus may include one or more reels and pulleys used to move the superconducting tape into and out of a cryostat. The apparatus may also include a permanent magnet or electromagnet provided at a low temperature proximate to the tape. The magnet induces screening currents in the tape. The apparatus may also include an electric motor used to drive movement of the tape relative to the magnet. A tension meter may be provided to measure a tension of the tape. Alternatively, a current provided to the motor may also be measured. The apparatus may be used to measure the critical current at various positions on the superconducting tape at the low temperatures.

IPC Classes  ?

• G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
• G01R 33/38 - Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
• G01R 33/421 - Screening of main or gradient magnetic field

Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein is versatile polyene cyclization strategy that exploits conjugated β-ionyl derivatives. Photomediated disruption of the extended π-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C-Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.

IPC Classes  ?

• C07D 215/227 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
• C07C 13/68 - Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings the condensed ring system contains only four rings with a bridged ring system
• C07C 22/08 - Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings containing fluorine
• C07C 25/22 - Polycyclic aromatic halogenated hydrocarbons with condensed rings
• C07C 35/44 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed ring system having more than three rings
• C07C 43/215 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
• C07C 49/753 - Unsaturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
• C07C 49/755 - Unsaturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
• C07D 215/06 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
• C07D 307/79 - Benzo [b] furansHydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Abstract

Disclosed herein are methods and kits for quantifying the presence of a microorganism in a sample. Specifically, disclosed are methods for quantifying a pathogen in a sample, such as a food sample, to determine if the levels of pathogen present in the sample are within an acceptable range.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12Q 1/6851 - Quantitative amplification

Abstract

The disclosure relates to devices, systems and methods implementing a charge pump gate driver (CPGD) that offers adjustable pump voltage, enabling online and active dv/dt and di/dt control for power devices, including the wide bandgap devices, such as SiC MOSFETs and GaN HEMTs. The disclosed CPGD allows a flexible pump voltage adjustment through the pre-charging interval control. Both the turn-on and turn-off switching speed (both dv/dt and di/dt) of power devices can be online regulated rapidly within each switching cycle, without interrupting the power converter operation. The disclosed CPGD has a simple structure and eliminates the extra power supplies to reduce circuit cost and footprint.

IPC Classes  ?

• H03K 17/06 - Modifications for ensuring a fully conducting state
• H03K 17/0412 - Modifications for accelerating switching without feedback from the output circuit to the control circuit by measures taken in the control circuit
• H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors

Abstract

Systems, devices, and methods are described herein that facilitate using predictive-control based LVRT methods for grid-tied inverters.

IPC Classes  ?

• H02M 7/539 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency
• H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks

Abstract

Disclosed are methods of forming lignin-based biodegradable polymers. The methods comprise the use of a coupling reagent allowing formation between lignin-based material and an additional polymer material. The formed polymers include lignin-based polycarbonates, lignin-based polyurethanes, and lignin-based polyesters.

IPC Classes  ?

• C08L 97/00 - Compositions of lignin-containing materials
• C08K 5/3445 - Five-membered rings
• C08L 67/00 - Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chainCompositions of derivatives of such polymers
• C08L 69/00 - Compositions of polycarbonatesCompositions of derivatives of polycarbonates
• C08L 75/04 - Polyurethanes

Abstract

Disclosed are methods of forming lignin-based recyclable polymers. The methods comprise using a carbon dioxide-containing gas as a reagent to form a lignin-based polycarbonate. Also disclosed are methods for capturing carbon dioxide gas and recycling lignin-based materials.

IPC Classes  ?

• C08G 64/02 - Aliphatic polycarbonates
• C07D 319/06 - 1,3-DioxanesHydrogenated 1,3-dioxanes not condensed with other rings
• C08G 64/30 - General preparatory processes using carbonates

Abstract

Example coil guns and methods of using coil guns are described herein. An example coil gun includes a first pancake module; a second pancake module, where the first pancake module and the second pancake module are each formed of a winding with an inner superconducting material layer and an outer ordinary conductor layer, where the first pancake module and the second pancake module are physically and/or inductively coupled to propagate a quench of a superconducting state of the first pancake module to the second pancake module.

IPC Classes  ?

• B64G 1/00 - Cosmonautic vehicles
• H01F 6/00 - Superconducting magnetsSuperconducting coils
• H01F 6/02 - QuenchingProtection arrangements during quenching

Abstract

In one aspect, the disclosure a system for near infrared-to-green upconversion of light in solid-state optoelectronic devices, the system comprising a bulk semiconductor layer capable of absorbing a near-infrared first wavelength of light and an organic annihilator in contact with the bulk semiconductor, wherein the organic annihilator is capable of upconversion via triplet-triplet annihilation from triplet states in the organic annihilator to produce green light at a second wavelength. In one aspect, the bulk semiconductor can be a formamidinium-based metal halide perovskite and the organic annihilator can be a polycyclic aromatic hydrocarbon or derivative thereof. Also disclosed are devices incorporating the same and methods for upconverting near infrared light to green light.

IPC Classes  ?

• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 30/50 - Photovoltaic [PV] devices
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

Methods of passivating a surface. The methods may include providing a mixture including a liquid and a derivative of quinacridone, applying the mixture to a first surface of a film that includes a metal halide perovskite, and annealing the film for a time and a temperature effective to convert the derivative of quinacridone to quinacridone. Composite materials and electronic devices also are provided.

IPC Classes  ?

• H10K 30/88 - PassivationContainersEncapsulations
• B05D 1/00 - Processes for applying liquids or other fluent materials
• H10K 30/10 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising heterojunctions between organic semiconductors and inorganic semiconductors

Abstract

Methods of passivating a surface. The methods may include providing a mixture including a liquid and a derivative of quinacridone, applying the mixture to a first surface of a film that includes a metal halide perovskite, and annealing the film for a time and a temperature effective to convert the derivative of quinacridone to quinacridone. Composite materials and electronic devices also are provided.

IPC Classes  ?

• H10K 30/88 - PassivationContainersEncapsulations
• B05D 1/00 - Processes for applying liquids or other fluent materials
• H10K 30/10 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising heterojunctions between organic semiconductors and inorganic semiconductors

Abstract

Disclosed are methods of forming lignin-based recyclable polymers. The methods comprise using a carbon dioxide-containing gas as a reagent to form a lignin-based polycarbonate. Also disclosed are methods for capturing carbon dioxide gas and recycling lignin-based materials.

IPC Classes  ?

• C08L 97/00 - Compositions of lignin-containing materials
• C08L 97/02 - Lignocellulosic material, e.g. wood, straw or bagasse
• C08G 64/42 - Chemical after-treatment
• C08G 64/30 - General preparatory processes using carbonates

Abstract

Systems and methods are provided for in situ observation of reservoirs, such as syringes, during the freeze thaw cycle to allow for more in depth understanding of the behavior of the system. The systems and methods may include an inert environment and/or a low concentration (e.g., on the order of parts per million (ppm)) of water, which may inhibit frost formation.

IPC Classes  ?

• F17C 13/02 - Special adaptations of indicating, measuring, or monitoring equipment

Abstract

Disclosed are methods of forming lignin-based biodegradable polymers. The methods comprise the use of a coupling reagent allowing formation between lignin-based material and an additional polymer material. The formed polymers include lignin-based polycarbonates, lignin-based polyurethanes, and lignin-based polyesters.

IPC Classes  ?

• B01J 20/26 - Synthetic macromolecular compounds
• C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
• C08L 51/00 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
• C08F 289/00 - Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups
• C01B 32/50 - Carbon dioxide

Abstract

Described herein are systems and methods for performing literature retrieval and related machine learning model training methods. An example computer-implemented method of training a machine learning model configured for literature retrieval I includes receiving a plurality of full-text articles; extracting, from the plurality of full-text articles, a plurality of positive sentence-citation pairs, each positive sentence-citation pair comprising a respective citing sentence and at least one cited article that is associated with the respective citing sentence; creating a labeled dataset comprising the plurality of positive sentence-citation pairs; and training a machine learning model using the labeled dataset.

IPC Classes  ?

• G06F 40/216 - Parsing using statistical methods
• G06N 3/091 - Active learning

Abstract

Organic photovoltaic materials (OPV) and devices using the same are provided, as well as methods of fabricating and using the same. An OPV material can be used as a photo-absorbing layer for mechanoluminescent (ML) light (e.g., in a flexible organic ML photodiode). The OPV material can include, for example, a blend of a donor polymer (e.g., P3HT) and a non-halogenated, non-fullerene acceptor (e.g., Y6).

IPC Classes  ?

• H10K 85/10 - Organic polymers or oligomers
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

Contrast agents, compositions including contrast agents, methods of forming contrast agents, and methods of imaging. Contrast agents may have a desirable solubility in liquids, such as aqueous liquids. Methods of forming contrast agents may include contacting a polymer that includes anhydride functional groups with one or more compounds. Methods of imaging may include administering to patients a contrast agent or composition including a contrast agent.

IPC Classes  ?

• A61K 49/12 - Macromolecular compounds

Abstract

Described herein stabilized polysiloxane particles and methods for making and using the same. In one aspect, the composite includes (a) a polysiloxane comprising one or more positively charged groups and a negatively charged polyelectrolyte polymer or (b) a polysiloxane comprising one or more negatively charged groups and a positively charged polyelectrolyte polymer. Additionally, components such as, for example, inorganic drying agent, a filler, a reinforcing agent, magnetic particles, a wet/dry indicator, a pharmaceutical agent, a catalyst, or any combination thereof. The composites are effective in encapsulating hydrophobic materials that can subsequently be dispersed in aqueous medium.

IPC Classes  ?

• C08L 83/04 - Polysiloxanes
• C09D 183/04 - Polysiloxanes

Abstract

The present invention includes scalable and cost-effective auxetic foam sensors (AFS) created through conformably coating a thin conductive nanomaterial-sensing layer on a porous substrate having a negative Poisson's ratio. In general, the auxetic foam sensors possess multimodal sensing capability, such as large deformation sensing, small pressure sensing, shear/torsion sensing and vibration sensing and excellent robustness in humidity environment.

IPC Classes  ?

• G01L 1/18 - Measuring force or stress, in general using properties of piezo-resistive materials, i.e. materials of which the ohmic resistance varies according to changes in magnitude or direction of force applied to the material
• G01L 1/22 - Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluidsMeasuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress using resistance strain gauges
• G01R 29/22 - Measuring piezoelectric properties
• B32B 37/24 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer not being coherent before laminating, e.g. made up from granular material sprinkled onto a substrate
• B29C 44/34 - Component parts, details or accessoriesAuxiliary operations
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G01L 1/26 - Auxiliary measures taken, or devices used, in connection with the measurement of force, e.g. for preventing influence of transverse components of force, for preventing overload

Abstract

Organic metal halide hybrid-based scintillation materials are provided, as well as methods of fabricating and using the same. The scintillation materials can be zero-dimensional (0D) organic metal halide hybrid-based scintillation materials, such as 4-(4-(diphenylamino) phenyl)-1-(Propyl)-pyrindin-lium zinc bromide ((TPA-P)2ZnBr4), in which at least one metal halide anion (e.g., ZnBr42−) act(s) as an X-ray sensitizer and at least one aggregate induced emission (AIE) organic cation (e.g., TPA-P+) act(s) as a light emitter.

IPC Classes  ?

• C09K 11/54 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing zinc or cadmium
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

2444 2-) act(s) as an X-ray sensitizer and at least one aggregate induced emission (AIE) organic cation (e.g., TPA-P+) act(s) as a light emitter.

IPC Classes  ?

• G01T 1/00 - Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation

Abstract

Determining whether a particular sample is what it is labeled or sold as is an important concept, particularly to those who buy or sell food products. Particularly for end users, a fast, efficient, accurate way of determining whether a sample is being accurately marketed and sold is necessary. This invention allows a user to rapidly determine if a product is from a certain species or not, based on genetic markers for that product.

IPC Classes  ?

• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

A device may include a transcranial magnetic stimulation (TMS) device configured to generate a localized magnetic field waveform at a brain region. A device may include an acoustic controller configured to generate an audio waveform having at least one of rhythm, harmonic element, or melodic element synchronized to the localized magnetic field waveform. In various implementations, the brain region is a motor cortex of a patient. The device can evoke or produce neurostimulation effects through acoustic stimulation (e.g., music) through classical (or Pavlovian) conditioning paired in combination with synchronized transcranial magnetic stimulation output. The device can be used to extend the effects of neuromodulation, thus reducing the burden of in-patient visits (for procedural neurostimulation), reducing battery life demand of implanted devices, or simply improving the patient experience with achieving benefits (i.e., by listening to music versus unnatural sensory sensations with neurostimulation).

IPC Classes  ?

• A61N 2/00 - Magnetotherapy
• A61B 5/395 - Details of stimulation, e.g. nerve stimulation to elicit EMG response
• A61N 2/02 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
• G10H 1/00 - Details of electrophonic musical instruments

Abstract

A system may measure, via a functional Near-Infrared Spectroscopy (fNIRS) device, a first set of measurements of a prefrontal cortex region of a patient. The system may perform, via a transcranial magnetic stimulation (TMS) device, TMS treatment to the prefrontal cortex region for therapeutic effect. The fNIRS device may measure a second set of measurements of the prefrontal cortex region. The system includes a processor to determine an applied dosing of the TMS treatment based on the first set of measurements and/or the second set of measurements. The system may output control feedback to the TMS device or visualization to a display to adjust one or more parameters or localization of the TMS treatment based on the applied dosing. The system personalizes the treatment dosing of TMS more accurately over the prefrontal cortex by calibrating the dose to the prefrontal cortex based on measurements from the fNIRS device.

IPC Classes  ?

• A61N 2/00 - Magnetotherapy
• A61N 2/02 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Abstract

The present disclosure relates generally to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly referred to as coronavirus disease 2019 (COVID-19). The present disclosure relates more particularly to small molecule inhibitors of SARS-CoV-2 of Formula (II) and prodrug derivatives thereof of Formula (I), and methods of treating COVID-19 therewith. The present disclosure relates generally to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly referred to as coronavirus disease 2019 (COVID-19). The present disclosure relates more particularly to small molecule inhibitors of SARS-CoV-2 of Formula (II) and prodrug derivatives thereof of Formula (I), and methods of treating COVID-19 therewith.

IPC Classes  ?

• C07C 235/84 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• C07D 211/46 - Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
• C07D 209/26 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
• C07D 277/44 - Acylated amino or imino radicals
• A61P 31/14 - Antivirals for RNA viruses
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07D 215/50 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

Abstract

Improved hybrid neurovascular spheroids and methods for making the same are provided. In some embodiments of a method for making a hybrid neurovascular spheroid, the method includes i) propagating cortical cells to form a cortical spheroid; ii) propagating endothelial cells to form an endothelial spheroid; iii) propagating mesenchymal stem cells to form a mesenchymal cell culture; and iv) combining the cortical spheroid, endothelial spheroid, and mesenchymal spheroid under conditions to form the hybrid neurovascular spheroid.

IPC Classes  ?

• C12N 5/079 - Neural cells

Abstract

An induction machine with localized voltage unbalance compensation is disclosed. The use of an induction machine with a voltage unbalance correction compensator (VUC) may be used to maintain proper working conditions of the machine during intervals of voltage unbalance.

IPC Classes  ?

• H02P 29/024 - Detecting a fault condition, e.g. short circuit, locked rotor, open circuit or loss of load
• H02P 1/26 - Arrangements for starting electric motors or dynamo-electric converters for starting dynamo-electric motors or dynamo-electric converters for starting an individual polyphase induction motor
• G01R 31/34 - Testing dynamo-electric machines
• H02K 15/16 - Centring rotors within the stators

Abstract

The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

IPC Classes  ?

• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/28 - DrageesCoated pills or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/38 - CelluloseDerivatives thereof
• A61K 47/40 - CyclodextrinsDerivatives thereof

Abstract

Bulk assemblies are provided, which may have desirable photoluminescence quantum efficiencies. The bulk assemblies may include two or more metal halides, and a wide band gap organic network. The wide band gap organic network may include organic cations. The metal halides may be disposed in the wide band gap organic network. Light emitting composite materials also are provided.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• C09K 11/74 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing arsenic, antimony or bismuth
• C09K 11/77 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing rare earth metals
• H05B 33/14 - Light sources with substantially two-dimensional radiating surfaces characterised by the chemical or physical composition or the arrangement of the electroluminescent material
• H05B 33/20 - Light sources with substantially two-dimensional radiating surfaces characterised by the chemical or physical composition or the arrangement of the material in which the electroluminescent material is embedded

Abstract

In one aspect, the disclosure relates to cytosolic microparticles comprising a polymeric material such as, for example, poly(N-isopropylacrylamide) (PNIPAM), and containing nanoparticles, and methods for producing the same. The disclosure further relates to phagocytic cells such as macrophages containing the cytosolic microparticles, wherein the microparticles are not subject to the harsh environment of the phagosome. Also disclosed are compositions containing the phagocytic cells and methods for treating diseases in a subject, including various cancers, wherein the methods include administering the phagocytic cells or disclosed compositions to a subject.

IPC Classes  ?

• C08F 220/54 - Amides
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61P 35/00 - Antineoplastic agents
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 33/26 - IronCompounds thereof
• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters

Abstract

Methods of preparation of lysergic acid and derivatives thereof. Methods of using lysergic acid and derivatives thereof, such as methods of treating neurodegenerative disorders. Derivatives of lysergic acid and pharmaceutically acceptable salts thereof.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 457/04 - Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula: , e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
• C07D 457/06 - Lysergic acid amides
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 31/48 - Ergoline derivatives, e.g. lysergic acid, ergotamine

Abstract

Methods of preparation of lysergic acid and derivatives thereof. Methods of using lysergic acid and derivatives thereof, such as methods of treating neurodegenerative disorders. Derivatives of lysergic acid and pharmaceutically acceptable salts thereof.

IPC Classes  ?

• C07D 457/02 - Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula: , e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
• B01J 23/44 - Palladium

Abstract

Apparatuses and methods for removing caps, such as NMR rotor caps. The apparatuses and methods may permit caps to be removed in a manner that minimizes damage to equipment and instruments. Microwave waveguides that may include an elongated waveguide, a spline horn, and a slotted waveguide. Analytical instruments that include the waveguides.

IPC Classes  ?

• G01R 33/30 - Sample handling arrangements, e.g. sample cells, spinning mechanisms

Abstract

Apparatuses and methods for removing caps, such as NMR rotor caps. The apparatuses and methods may permit caps to be removed in a manner that minimizes damage to equipment and instruments. Microwave waveguides that may include an elongated waveguide, a spline horn, and a slotted waveguide. Analytical instruments that include the waveguides.

IPC Classes  ?

• G01R 33/30 - Sample handling arrangements, e.g. sample cells, spinning mechanisms

Abstract

0≤x≤2, 0≤y<1, and 0≤z≤2, except that cases i) x and y and z are simultaneously 0, ii) M is Hf, X is F, x is 1, y is 0, and z is 1, iii) M is Hf, X is Cl, x is 2, y is 0, and z is 2, and iv) M is Hf, X is F, x is 2, y is 0, and z is 2.

IPC Classes  ?

• H01M 10/0562 - Solid materials
• C01B 25/45 - Phosphates containing plural metal, or metal and ammonium
• C01B 25/455 - Phosphates containing halogen
• C01B 33/32 - Alkali metal silicates
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

Photovoltaic devices, and methods of fabricating photovoltaic devices. The photovoltaic devices may include a first electrode, at least one quantum dot layer, at least one semiconductor layer, and a second electrode. The first electrode may include a layer including Cr and one or more silver contacts.

IPC Classes  ?

• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H01L 31/0224 - Electrodes
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
• H01L 31/032 - Inorganic materials including, apart from doping materials or other impurities, only compounds not provided for in groups

Abstract

DNA or RNA including a target nucleotide sequence are amplified by placing a probe nucleotide sequence on the DNA or RNA. The probe nucleotide sequence is complementary to the target nucleotide sequence. The interaction between the probe nucleotide sequence and target nucleotide sequence causes the single-stranded DNA to form a hairpin. The hairpinned single-stranded DNA are selected for amplification.

IPC Classes  ?

• C12Q 1/6855 - Ligating adaptors

Abstract

Contrast agents, compositions including contrast agents, methods of forming contrast agents, and methods of imaging. Contrast agents may have a desirable solubility in liquids, such as aqueous liquids. Methods of forming contrast agents may include contacting a polymer that includes anhydride functional groups with one or more compounds. Methods of imaging may include administering to patients a contrast agent or composition including a contrast agent.

IPC Classes  ?

• A61K 49/12 - Macromolecular compounds

Abstract

Photovoltaic devices, and methods of fabricating photovoltaic devices. The photovoltaic devices may include a first electrode, at least one quantum dot layer, at least one semiconductor layer, and a second electrode. The first electrode may include a layer including Cr and one or more silver contacts.

IPC Classes  ?

• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H01L 31/0224 - Electrodes
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
• H01L 31/032 - Inorganic materials including, apart from doping materials or other impurities, only compounds not provided for in groups

Abstract

Various implementations include a mold for forming composite samples for a pullout test. The mold includes a body having a first surface and a second surface spaced apart from the first surface. The first surface defines one or more slots and one or more channels. Each of the one or more channels has a longitudinal axis. At least one of the one or more channels intersects one of the one or more slots. Various other implementations include a method of forming a composite sample for a pullout test. The method includes providing a mold as described above; disposing a resin within one of the slots; disposing a fiber within at least one of the channels intersecting the one of the slots such that a portion of the fiber is disposed within the one of the slots; and causing the resin to cure.

IPC Classes  ?

• G01N 1/36 - Embedding or analogous mounting of samples

Abstract

The invention concerns molecular biomarkers useful for screening individuals for steroid resistance and steroid sensitivity in the selection of treatments for keloids and other conditions. Aspects of the invention include a method for determining whether or not an individual will respond beneficially to a steroid therapy; a method for selecting a therapy for an individual having a condition, using the screening method; a method for treating a condition of an individual, using the screening method; and a detection device useful for detecting expression levels of the biomarkers.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present disclosure provides for a method of detecting the displacement of a specific analyte, including providing an indicator in an organic phase to form a first composition; providing an aqueous phase with a test analyte to form a second composition; adding at least one organic solute to the organic phase; putting the first composition and second composition in contact with each other, thereby forming a lamellar phase and an interface between the first composition and second composition; and detecting the presence of the indicator in the organic phase, wherein the presence of the indicator in the organic phase indicates the presence of the specific analyte. The present disclosure also provides for a method of developing a high throughput assay for contemporaneous detection of multiple analytes. Further, the present disclosure provides for a biosensor for detection of a specific analyte.

IPC Classes  ?

• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Fluorescent collagen a1(I) and a2(I) mRNA compounds can be used to detect whether a test compound affects the binding of collagen a1(I) and/or a2(I) mRNAs to LARP6 protein. Fluorescent collagen a1(I) and a2(I) mRNA compounds include collagen a1(I) and a2(I) mRNA sequences that have been tagged with a fluorophore and have LARP6 binding affinity.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

bb-ionyl derivatives. Photomediated disruption of the extended p-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C–Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.

IPC Classes  ?

• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61P 35/00 - Antineoplastic agents
• C07C 49/587 - Unsaturated compounds containing a keto group being part of a ring

Abstract

Photopolymers, monomers, compositions including photopolymers and a dopant, and methods, including methods for eliciting a photomechanical response. The dopant may be a triplet sensitizing dopant. The exposing of compositions to the one or more wavelengths of electromagnetic radiation may elicit a photomechanical response via a triplet excited state mechanism.

IPC Classes  ?

• H10K 85/10 - Organic polymers or oligomers
• H10K 30/00 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation
• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromoleculePolyhydrazidesPolyamide acids or similar polyimide precursors

Abstract

A magnet includes a stack of a plurality of superconducting pancake wound coils having a stacking axis normal to a winding direction of the coils. The stack has axial ends and has a stack midplane relative to the stacking axis. A quench detector is provided for detecting a quench in the stack of superconducting pancake wound coils. A plurality of resistance quench heaters (RQH) are distributed symmetrically along the axis with respect to the stack midplane. Control circuitry is provided for controlling the operation of the RQH upon the detection of a quench by the quench detector. A method of quenching a magnet is also disclosed.

IPC Classes  ?

• H01F 6/02 - QuenchingProtection arrangements during quenching
• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

Abstract

Multi-media parcel delivery systems and associated methods are provided herein including systems capable of delivering a parcel through air and one or more bodies of water. In certain embodiments, an aerial vehicle is configured to couple to the parcel using a cable. A control system is used to control operating parameters including velocity, altitude, and pose of the aerial vehicle, and a length and orientation of the cable extending between the aerial vehicle and the parcel.

IPC Classes  ?

• B64D 1/22 - Taking-up articles from earth's surface
• B64U 80/86 - Land vehicles
• B64U 10/14 - Flying platforms with four distinct rotor axes, e.g. quadcopters
• G05D 1/08 - Control of attitude, i.e. control of roll, pitch, or yaw
• G05D 1/06 - Rate of change of altitude or depth

Abstract

Provided herein are photochemical separations. The methods herein can include exposing a first metal complex and a second metal complex to light to facilitate an irreversible chemical reaction to form a modified first metal complex. The modified first metal complex then may be separated from the second metal complex. Compositions also are provided.

IPC Classes  ?

• C07B 63/02 - PurificationSeparation specially adapted for the purpose of recovering organic compoundsStabilisationUse of additives by treatment giving rise to a chemical modification
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• C07F 15/02 - Iron compounds

Abstract

A non-intrusive, in-situ power method for measuring the loss associated with magnetic components (for example, an inductor) of a power converter is provided. The method involves first capturing a first set of voltage and current waveforms from the power converter. An additional capacitor is then connected to the power converter and a second set of voltage and current waveforms are captured. Based on the first set of waveforms and the second set of waveforms, a timing skew between the current and voltage waveforms captured from the power converter may be determined. This timing skew may then be used to determine the loss of the inductor. The loss may be used to design an optimized power converter.

IPC Classes  ?

• G01R 31/40 - Testing power supplies
• G01R 21/06 - Arrangements for measuring electric power or power factor by measuring current and voltage

Abstract

Disclosed herein are methods and kits for quantifying the presence of a microorganism in a sample. Specifically, disclosed are methods for quantifying a pathogen in a sample, such as a food sample, to determine if the levels of pathogen present in the sample are within an acceptable range.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12R 1/42 - Salmonella

Abstract

Bioreactors and associated methods are provided herein including bioreactors capable of treating water contaminated with 1,4-dioxane. In certain embodiments, a bioreactor is disclosed and may include an adsorbent layer with a biofilm capable of metabolizing 1,4-dioxane and a screen disposed downstream of the adsorbent layer configured to retain detached biofilm.

IPC Classes  ?

• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used

Abstract

A synthetic foldable protein has a tertiary structure emulating the tertiary structure of a reference foldable protein. The reference foldable protein has a folding nucleus peptide sequence associated with folding the reference foldable protein. The synthetic foldable protein also has a peptide sequence including the folding nucleus peptide sequence and at least one repeat thereof.

IPC Classes  ?

• C07K 14/50 - Fibroblast growth factor [FGF]

Abstract

Disclosed herein are systems and methods for removing trichloroethane (TCA), trichloroethene (TCE), and 1,4-dioxane (1,4-D) from contaminated liquids. The system and methods rely on catalyst reduction of TCA and TCE, where the reduced products are then degraded by microorganisms The system comprises a first reactor comprising a catalyst film of precious metal nanoparticles deposited on a first nonporous membrane and a second reactor comprising a biofilm of microorganisms that are capable of degrading ethane and 1,4-D deposited on a second nonporous membrane. The first reactor further comprises a hydrogen gas source, wherein the hydrogen gas source delivers hydrogen to the gas-phase side of the first nonporous membrane, and the catalyst film is deposited on the liquid-phase side. The second reactor further comprises an oxygen gas source, wherein the oxygen gas source delivers oxygen to the gas-phase side of the second non-porous membrane, and the biofilm is deposited on the liquid-phase side.

IPC Classes  ?

• C02F 1/70 - Treatment of water, waste water, or sewage by reduction
• B01J 23/44 - Palladium
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/23 - Catalysts, in general, characterised by their form or physical properties characterised by their non-solid state in a colloidal state
• B01J 35/30 - Catalysts, in general, characterised by their form or physical properties characterised by their physical properties
• B01J 35/39 - Photocatalytic properties
• C02F 3/10 - PackingsFillingsGrids
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C02F 101/34 - Organic compounds containing oxygen
• C02F 101/36 - Organic compounds containing halogen

Abstract

Composite materials that include a plurality of nanofibers and a ceramic. Methods of forming composite materials, which may include removing a liquid from a dispersion that includes a plurality of nanofibers, a pre-ceramic precursor, and a liquid to form an intermediate material, and annealing the intermediate material. A pre-ceramic precursor may be added before or after removal of a liquid. An article having a surface on which a composite material is disposed.

IPC Classes  ?

• C04B 35/80 - Fibres, filaments, whiskers, platelets, or the like
• C04B 35/626 - Preparing or treating the powders individually or as batches
• C04B 35/64 - Burning or sintering processes
• C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products

Abstract

A new type of charge transport layer based on organometal halide perovskite for highly efficient organic light emitting diodes (OLEDs) is demonstrated. By solution processing of halide perovskite precursors, smooth essentially pure perovskite thin films may be prepared with high transparency and conductivity. Solution processed multilayer OLED with this perovskite-based hole transport layer outperforms a device with a PEDOT:PSS layer.

IPC Classes  ?

• H10K 30/10 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising heterojunctions between organic semiconductors and inorganic semiconductors
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 50/15 - Hole transporting layers
• H10K 50/16 - Electron transporting layers
• H10K 85/60 - Organic compounds having low molecular weight
• H10K 85/10 - Organic polymers or oligomers
• H10K 85/30 - Coordination compounds
• H10K 71/00 - Manufacture or treatment specially adapted for the organic devices covered by this subclass
• H10K 71/40 - Thermal treatment, e.g. annealing in the presence of a solvent vapour
• H10K 101/10 - Triplet emission
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating

Abstract

Systems and methods are provided for producing optimized electronic components. Particularly, the systems and methods may involve the use of a "three-legged approach" for determining design parameters for electrical components (and/or insulation of the electrical components) such that the electrical component is not subject to partial discharges (PDs) at a maximum operating voltage of the electrical component. The approach may involve extracting maximum bulk (e.g., orthogonal) and surface (e.g., tangential) electrical stress (e.g., electrical field) information at operating temperatures, comparing the values of these electric fields with electric field values that are likely to cause the inception of one or more PDs in the electrical component (which may be determined through modeling), and linking these results with PD measurements (such as the surface partial discharge inception voltage, SPDIV).

IPC Classes  ?

• G01R 31/12 - Testing dielectric strength or breakdown voltage
• G01R 31/14 - Circuits therefor

Abstract

The present disclosure provides for a method of making a plant growth medium comprising isolating cellulose nanocrystals from a feedstock, and adding the cellulose nanocrystals to the plant growth medium. Further provided herein is a plant starter plug comprising the plant growth medium. Also provided herein is a plant growth medium comprising germination material and cellulose nanocrystals, and a plant starter plug comprising thereof. The present disclosure further provides for a method of isolating CNCs from waste.

IPC Classes  ?

• A01G 24/22 - Growth substratesCulture mediaApparatus or methods therefor based on or containing natural organic material containing plant material
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C12N 9/42 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase

Abstract

Methods are provided for treating disorders associated with default mode network (DMN) dysfunction in a patient, where the methods include administering alpha-frequency transcranial alternating current stimulation (α-tACS) to the brain of the patient via at least one electrode, and where the α-tACS is effective to regulate DMN dysfunction and treat disorders associated therewith. Diseases and disorders associated with DMN dysfunction include normal or abnormal aging, cognitive impairment, or neuropsychiatric disorders such as Alzheimer's disease, schizophrenia, autism, or posttraumatic stress disorder (PTSD).

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes

Abstract

Methods of encapsulating perovskites, such as metal halide perovskites, that may include depositing a nitride or an oxide on a film that includes a perovskite. Composite materials that include a perovskite layer and a layer of a nitride or an oxide. Devices, such as electronic devices, that include composite materials.

IPC Classes  ?

• H10K 50/844 - Encapsulations
• H10K 30/88 - PassivationContainersEncapsulations

Abstract

A compound of Formula 1 A compound of Formula 1 Li1+(4−a)αHf2−αMaα(PO4−δ)3  (1) A compound of Formula 1 Li1+(4−a)αHf2−αMaα(PO4−δ)3  (1) is disclosed, wherein M is at least one cationic element having a valence of a, wherein 0<α≤⅔, 1≤a≤4, and 0≤δ≤0.1. Also described are an electrolyte composition, a separator, a protected positive electrode, a protected negative electrode, and a lithium battery, each including the compound of Formula 1.

IPC Classes  ?

• H01M 10/0562 - Solid materials
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• C01G 27/00 - Compounds of hafnium
• H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
• C01B 25/37 - Phosphates of heavy metals
• H01M 50/451 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising layers of only organic material and layers containing inorganic material
• H01M 50/454 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising a non-fibrous layer and a fibrous layer superimposed on one another

Abstract

Methods are provided for treating disorders associated with default mode network (DMN) dysfunction in a patient, where the methods include administering alpha-frequency transcranial alternating current stimulation (α-tACS) to the brain of the patient via at least one electrode, and where the α-tACS is effective to regulate DMN dysfunction and treat disorders associated therewith. Diseases and disorders associated with DMN dysfunction include normal or abnormal aging, cognitive impairment, or neuropsychiatric disorders such as Alzheimer's disease, schizophrenia, autism, or posttraumatic stress disorder (PTSD).

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

Provided are methods and apparatus for recovering collided packets in a wireless network, as well as for implementing block-based error correction techniques. In an example, provided is a method to recover collided packets by (A) assigning a peak of a collided packet to a respective packet by calculating a matching cost, per collided packet, from an amplitude of the peak and a time when the peak occurred, where the matching cost is determined from a combination of per-collided packet parameters including (i) respective estimated symbol boundaries of the collided packets, (ii) respective estimated Carrier Frequency Offsets of the collided packets, and (iii) a peak amplitude history of prior packets received from wireless network nodes, and (B) assigning, based on a respective packet in the collided packets having the parameters producing a lowest matching cost among the calculated matching costs, the peak to the respective packet.

IPC Classes  ?

• H04W 74/08 - Non-scheduled access, e.g. ALOHA
• H04W 72/0453 - Resources in frequency domain, e.g. a carrier in FDMA

Abstract

A dual multi-level inverter topology with reduced switch count and small DC-link capacitor is provided. The inverter topology provides multi-level inverter operation without requiring a neutral point connection that is commonly present in a stacked capacitor topology (for example, a topology including two capacitors).

IPC Classes  ?

• H02M 7/483 - Converters with outputs that each can have more than two voltage levels
• H02M 7/487 - Neutral point clamped inverters
• H02M 1/12 - Arrangements for reducing harmonics from AC input or output
• H02M 1/00 - Details of apparatus for conversion

Abstract

Coils for superconducting magnets and methods of making coils for superconducting magnets and controlling the turn-to-turn contact resistance of coils. The coils include a REBCO superconducting tape coated with a layer of tin-lead solder, co-wound with an oxidized stainless steel tape. The inclusion of tin-lead solder on the REBCO tape and a layer of oxidation on the stainless steel tape advantageously allow for tuning of the turn-to-turn contact resistance of the coil, and advantageously mitigates the effect of repeated pressure cycling on the turn-to-turn contact resistance.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils
• G01R 33/3815 - Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using electromagnets with superconducting coils, e.g. power supply therefor
• H01B 12/06 - Films or wires on bases or cores
• H10N 60/01 - Manufacture or treatment
• H10N 60/20 - Permanent superconducting devices
• H10N 60/80 - Constructional details