FONDAZIONE PER ADROTERAPIA ONCOLOGICA - TERA (Italy)
Inventor
Amaldi, Ugo
Abstract
An improved beam transport line is described for a proton or ion accelerator that guides protons or ions from the accelerator to a dose distribution system. The accelerator, beam transport line and dose distribution system are controllable by a control system. The beam transport line includes a plurality of electromagnetic elements and at least one of these is connected to a 2-quadrant or 4-quadrant power supply unit arranged to produce a current that can be varied by the control system in less than 50 milliseconds so that, when the beam energy is changed to move the beam-spot in the direction of the beam, it is kept focused on a target with losses along the beam transport line and dose distribution system not greater than 10% and variations in the total widths transverse to the mid-height of the beam-spot of the beam not greater than 10%. This solves the problem of how to transport a beam of rapidly changing energy.
05 - Pharmaceutical, veterinary and sanitary products
30 - Basic staples, tea, coffee, baked goods and confectionery
35 - Advertising and business services
38 - Telecommunications services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
43 - Food and drink services, temporary accommodation
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Food for diabetics; Infant formula; Dietetic foods adapted for invalids; Nutritional supplements for animal foodstuffs; Dietetic foods adapted for medical use; Food for medically restricted diets; Homogenized food adapted for medical purposes; Dietetic foods for use in clinical nutrition; Dietary supplements for humans; Food for diabetics; Food supplements; Vitamin supplements; Nutritional supplements; Anti-oxidant supplements; Probiotic supplements; Anti-oxidant food supplements; Medical food supplements; Dietary and nutritional supplements; Mineral food supplements; Mineral nutritional supplements; Liquid vitamin supplements; Protein dietary supplements; Arginate dietary supplements; Pollen dietary supplements; Enzyme dietary supplements; Vitamin and mineral supplements; Lecithin dietary supplements; Lecithin dietary supplements; Dietary and nutritional supplements; Mineral food supplements; Dietary supplements consisting of vitamins; Dietary supplements for infants; Nutritional supplements; Calcium supplements; Dietary supplements and dietetic preparations; Dietary and nutritional supplements; Mineral dietary supplements for humans; Zinc dietary supplements; Dietary supplements for controlling cholesterol; Health food supplements made principally of minerals; Health food supplements made principally of vitamins; Health food supplements for persons with special dietary requirements; Nutritional supplements made of starch adapted for medical use; Food supplements consisting of amino acids; Pharmaceuticals; Pharmaceutical compositions; Cardiovascular pharmaceuticals; Pharmaceuticals and natural remedies; Anti-diabetic pharmaceuticals; Ocular pharmaceuticals; Pharmaceutical preparations for the treatment of cancer; Pharmaceutical preparations for treating arthritis; Pharmaceutical preparations for the prevention of osteoporosis; Pharmaceutical preparations for the prevention of allergies; Pharmaceutical preparations for treating rheumatological diseases; Pharmaceutical preparations for the treatment of hormonal disorders; Intravenous fluids used for rehydration, nutrition and the delivery of pharmaceutical preparations; Compounds for treating cancer; Biopharmaceuticals for the treatment of cancer; Pharmaceutical preparations and substances for the treatment of cancer; Pharmaceutical preparations and substances for the prevention of cancer; Pharmaceutical preparations and substances for use in oncology. Farinaceous foods; Foodstuffs made from cereals; Farinaceous foods; Foodstuffs made from maize; Oat-based food; Foodstuffs made of rice; Buckwheat-based foodstuffs; Breakfast cereals; Barley flour for food. Providing consumer product information relating to food or drink products; Advertising in relation to oncology provided by means of a database; Advertising in relation to pharmaceuticals provided online from a computer database or the internet. Transmission of information relating to pharmaceuticals for cancer, medicine; Communication by computer; Communication of information by computer; Mobile telephone communication services; Electronic transmission of data; Transmission of encrypted communications; Transmission of written communications (Electronic -); Communications by television for meeting; Communications by computer terminals; Communications via multinational telecommunication networks; Communications via a global computer network or the internet; rental of access time to a computerdatabase; Providing access to and leasing access time to computer databases; Providing telecommunications connections to a global computer network or databases. Training in the handling of food; Occupationally orientated instruction; Provision of training and education; Medical training and teaching; Conducting educational support programmes for patients; Provision of training courses; Courses (Training -) relating to medicine; Continuing medical training courses; Organisation of training courses; Arranging of lectures; Organisation of shows; Arranging of classes; Arranging of conferences; Organization of educational congresses; Organisation of seminars; Organising of entertainment; Organisation of teaching activities; Arranging of seminars relating to business; Organisation of educational events; Organization of educational congresses; Organisation of meetings and conferences; Arranging and conducting of congresses; Arranging of demonstrations for training purposes; Workshops (Arranging and conducting of -) [training]; Publication of texts, other than publicity texts; Publication of text books; Running seminars in the field of oncology; Library services provided by means of a computerised database containing information extracted from magazines and results of clinical studies in relation to oncology. Research of foodstuffs; Technical consultancy in relation to the technical research in the field of food and beverages; Technical consultancy in relation to research services relating to foods and dietary supplements; Pharmaceutical product evaluation; Testing of pharmaceuticals; Research on the subject of pharmaceuticals; Pharmaceutical products development; Pharmaceutical research and development; Development of pharmaceutical preparations and medicines; Research on the subject of pharmaceuticals; Conducting clinical trials for pharmaceutical products; Laboratory research services relating to pharmaceuticals; Conducting early evaluations in the field of new pharmaceuticals; Services for assessing the efficiency of pharmaceuticals; Providing information about the results of clinical trials for pharmaceutical products; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Electronic data storage; Computer system design; Scientific research for medical purposes in the area of cancerous diseases; Providing of information online in relation to research and clinical studies in relation to oncology from a computer database or the internet. Consultancy services relating to food. Providing nutritional information about food; Providing information relating to dietary and nutritional supplements; Pharmaceutical services; Provision of pharmaceutical information; Advisory services relating to pharmaceuticals; Individual medical counseling services provided to patients; Medical analysis services relating to the treatment of patients; Medical care and analysis services relating to patient treatment; Providing of information for patients relating to the administration of drugs and medicines; Providing medical support in the monitoring of patients receiving medical treatments; Medical laboratory services for the analysis of samples taken from patients; Bowel cancer screening services; Medical analysis services for the diagnosis of cancer; Medical advice for individuals with disabilities; Medical services in the field of oncology; Medical services provided by means of a database; Arranging of medical treatment; Providing on-line information relating to oncology; Information in relation to oncology provided online from a computer database or on the internet. Providing personal support services for cancer patients and their families.
05 - Pharmaceutical, veterinary and sanitary products
30 - Basic staples, tea, coffee, baked goods and confectionery
35 - Advertising and business services
38 - Telecommunications services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
43 - Food and drink services, temporary accommodation
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Food for diabetics; Infant formula; Dietetic foods adapted for invalids; Nutritional supplements for animal foodstuffs; Dietetic foods adapted for medical use; Food for medically restricted diets; Homogenized food adapted for medical purposes; Dietetic foods for use in clinical nutrition; Dietary supplements for humans; Food for diabetics; Food supplements; Vitamin supplements; Nutritional supplements; Anti-oxidant supplements; Probiotic supplements; Anti-oxidant food supplements; Medical food supplements; Dietary and nutritional supplements; Mineral food supplements; Mineral nutritional supplements; Liquid vitamin supplements; Protein dietary supplements; Arginate dietary supplements; Pollen dietary supplements; Enzyme dietary supplements; Vitamin and mineral supplements; Lecithin dietary supplements; Lecithin dietary supplements; Dietary and nutritional supplements; Mineral food supplements; Dietary supplements consisting of vitamins; Dietary supplements for infants; Nutritional supplements; Calcium supplements; Dietary supplements and dietetic preparations; Dietary and nutritional supplements; Mineral dietary supplements for humans; Zinc dietary supplements; Dietary supplements for controlling cholesterol; Health food supplements made principally of minerals; Health food supplements made principally of vitamins; Health food supplements for persons with special dietary requirements; Nutritional supplements made of starch adapted for medical use; Food supplements consisting of amino acids; Pharmaceuticals; Pharmaceutical compositions; Cardiovascular pharmaceuticals; Pharmaceuticals and natural remedies; Anti-diabetic pharmaceuticals; Ocular pharmaceuticals; Pharmaceutical preparations for the treatment of cancer; Pharmaceutical preparations for treating arthritis; Pharmaceutical preparations for the prevention of osteoporosis; Pharmaceutical preparations for the prevention of allergies; Pharmaceutical preparations for treating rheumatological diseases; Pharmaceutical preparations for the treatment of hormonal disorders; Intravenous fluids used for rehydration, nutrition and the delivery of pharmaceutical preparations; Compounds for treating cancer; Biopharmaceuticals for the treatment of cancer; Pharmaceutical preparations and substances for the treatment of cancer; Pharmaceutical preparations and substances for the prevention of cancer; Pharmaceutical preparations and substances for use in oncology. Farinaceous foods; Foodstuffs made from cereals; Farinaceous foods; Foodstuffs made from maize; Oat-based food; Foodstuffs made of rice; Buckwheat-based foodstuffs; Breakfast cereals; Barley flour for food. Providing consumer product information relating to food or drink products; Advertising in relation to oncology provided by means of a database; Advertising in relation to pharmaceuticals provided online from a computer database or the internet. Transmission of information relating to pharmaceuticals for cancer, medicine; Communication by computer; Communication of information by computer; Mobile telephone communication services; Electronic transmission of data; Transmission of encrypted communications; Transmission of written communications (Electronic -); Communications by television for meeting; Communications by computer terminals; Communications via multinational telecommunication networks; Communications via a global computer network or the internet; rental of access time to a computerdatabase; Providing access to and leasing access time to computer databases; Providing telecommunications connections to a global computer network or databases. Training in the handling of food; Occupationally orientated instruction; Provision of training and education; Medical training and teaching; Conducting educational support programmes for patients; Provision of training courses; Courses (Training -) relating to medicine; Continuing medical training courses; Organisation of training courses; Arranging of lectures; Organisation of shows; Arranging of classes; Arranging of conferences; Organization of educational congresses; Organisation of seminars; Organising of entertainment; Organisation of teaching activities; Arranging of seminars relating to business; Organisation of educational events; Organization of educational congresses; Organisation of meetings and conferences; Arranging and conducting of congresses; Arranging of demonstrations for training purposes; Workshops (Arranging and conducting of -) [training]; Publication of texts, other than publicity texts; Publication of text books; Running seminars in the field of oncology; Library services provided by means of a computerised database containing information extracted from magazines and results of clinical studies in relation to oncology. Research of foodstuffs; Technical consultancy in relation to the technical research in the field of food and beverages; Technical consultancy in relation to research services relating to foods and dietary supplements; Pharmaceutical product evaluation; Testing of pharmaceuticals; Research on the subject of pharmaceuticals; Pharmaceutical products development; Pharmaceutical research and development; Development of pharmaceutical preparations and medicines; Research on the subject of pharmaceuticals; Conducting clinical trials for pharmaceutical products; Laboratory research services relating to pharmaceuticals; Conducting early evaluations in the field of new pharmaceuticals; Services for assessing the efficiency of pharmaceuticals; Providing information about the results of clinical trials for pharmaceutical products; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Electronic data storage; Computer system design; Scientific research for medical purposes in the area of cancerous diseases; Providing of information online in relation to research and clinical studies in relation to oncology from a computer database or the internet. Consultancy services relating to food. Providing nutritional information about food; Providing information relating to dietary and nutritional supplements; Pharmaceutical services; Provision of pharmaceutical information; Advisory services relating to pharmaceuticals; Individual medical counseling services provided to patients; Medical analysis services relating to the treatment of patients; Medical care and analysis services relating to patient treatment; Providing of information for patients relating to the administration of drugs and medicines; Providing medical support in the monitoring of patients receiving medical treatments; Medical laboratory services for the analysis of samples taken from patients; Bowel cancer screening services; Medical analysis services for the diagnosis of cancer; Medical advice for individuals with disabilities; Medical services in the field of oncology; Medical services provided by means of a database; Arranging of medical treatment; Online in relation to oncology; Information in relation to oncology provided online from a computer database or on the internet. Providing personal support services for cancer patients and their families.
4.
USE OF LINEAR ION ACCELERATORS FOR THE TREATMENT OF ATRIAL FIBRILLATION AND ION ACCELERATOR SYSTEM THERE FOR
FONDAZIONE PER ADROTERAPIA ONCOLOGICA - TERA (Italy)
Inventor
Amaldi, Ugo
Abstract
The application of a system (12) is proposed for the acceleration of ions to treat Atrial Fibrillation (AF), arteriovenous malformations (AVMS) and focal epileptic lesions; this system (12) is composed of a pulsed ion source (1), a pre-accelerator (3) and one or more linear accelerators or linacs (5, 6, 7) operating at frequencies above 1 GHz with a repetition rate between 1 Hz and 500 Hz. The particle beam coming out of the complex (12) can vary in intensity (i), (acting on the ion source (1) ), (ii) in deposition depth (by independently adjusting the radiofrequency of the power sources that feed the linac accelerators units) and (iii) transversally with respect to the central beam direction (by varying the current in the coils of two orthogonal scanning magnets placed upstream of the patient). The possibility of adjusting in a few milliseconds and in three orthogonal directions, the location of each energy deposition in the body of the patient makes that system of accelerators (12) perfectly suited to irradiation of a beating heart.
FONDAZIONE PER ADROTERAPIA ONCOLOGICA - TERA (Italy)
Inventor
Amaldi, Ugo
Braccini, Saverio
Magrin, Giulio
Pearce, Peter
Zennaro, Riccardo
Abstract
The ion acceleration system or complex (T) for medical and/or other applications is composed in essence by an ion source (1), a pre-accelerator (3) and one or more linear accelerators or linacs (6, 8, 10, 13), at least one of which is mounted on a rotating mechanical gantry-like structure (17). Said isocentrical gantry (17) is equipped with a beam delivery system, which can be either 'active' or 'passive', for medical and/or other applications. The ion source (1) and the pre-accelerator (3) can be either installed on the floor, which is connected with the gantry basement, or mounted, fully or partially, on the rotating mechanical structure (17). The output beam can vary in energy and intensity pulse-by-pulse by adjusting the radio-frequency field in the accelerating modules of the linac(s) and the beam parameters at the input of the linear accelerators.
FONDAZIONE PER ADROTERAPIA ONCOLOGICA - TERA (Italy)
Inventor
Amaldi, Ugo
Abstract
A complex of proton accelerators, particularly devoted to medical applications, is disclosed comprising the following functionally interconnected components: a proton source, a cyclotron, at least one target, located either internally or externally to said cyclotron, a medium energy beam transport magnetic channel (MEBT), a radiofrequency linear accelerator (linac), a high energy beam transport channel (HEBT) towards an area dedicated to the irradiation of tumours with proton beams, as well as a modular system for supplying radio frequency (RF) power capable of feeding, independently two or more accelerating modules of said linac. An integrated computerized system controls said complex of accelerators so to carry out, either in alternation or simultaneously, both the production of radioisotopes - for medical, industrial and therapeutical purposes - and the therapeutical irradiation of, even deep seated tumours. Said complex of accelerators produces proton beams which, applying the recently developped 'spot scanning' technique, are more suited for the tumour irradiation than the ones produced by cyclotrons and synchrotrons. Moreover the proposed complex of accelerators requires a reduced energy consumption and, given its dual nature and presents a remarkable compactness that eases its installation in hospital and in research facilities dedicated to tumour diagnostics, brachitherapy and teletherapy.