A system has a digital health avatar can substitute to a neurologist, nurse practitioner, physical assistant or research coordinator (in the context of a clinical trial) to run efficiently a routine neurological examination and document the report. This avatar supports the neurologist in his/her work, and will not replace the neurologist who still need to use his/her expertise to do the final diagnostic and manage the patient disease.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
2.
CYBER-PHYSICAL SYSTEM TO ENHANCE USABILITY AND QUALITY OF TELEHEALTH CONSULTATION
A cyber-physical system for conducting a telehealth session. In embodiments, the system includes a hardware control box that enables patients (e.g., elderly or cognitively-impaired patients) to easily participate in the telehealth session. In some embodiments, the system analyzes sensor data (e.g., thermal images, eye tracking data, etc.) and calculates state variables that form a mathematical representation (a “digital twin”) indicative of the physical, emotive, cognitive, or social state of the patient. In some of those embodiments, the system calculates Myasthenia Gravis core examination metrics by performing computer vision analysis on patient video data and/or audio analysis on patient audio data. In some embodiments, the system controls a pan-tile-zoom camera to zoom in on each region of interest that is relevant to the examination. In some embodiments, the digital twin is used as an input of a heuristic computer reasoning system, which uses artificial intelligence to support clinical diagnosis and decision-making.
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
3.
MODIFIED BIOCHAR/COAL LIGNITES AND THEIR USE IN PHOSPHATE REMEDIATION AND AS SOLID AMENDMENTS
The present disclosure relates to improved processes for preparing modified lignite by reacting raw lignite with a source of magnesium (Mg2+) ions and a source of calcium (Ca2+) ions, washing the modified lignite (e.g., with water), drying, and pyrolyzing the treated lignite, and to the use of such products for phosphorous remediation.
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/30 - Processes for preparing, regenerating or reactivating
Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. Here, we provide a design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.
Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to immune checkpoint inhibitors. In certain embodiments, compositions herein can have at least one nanoparticle formed of Prussian blue materials and, optionally, one or more CD137 agonists. In other embodiments, methods of treating tumors herein can include administering an effective amount of at least photothermal therapy agent in combination with at least one CD137 agonist separately or in a combination therapy/combination composition.
Due to the precautions put in place during the COVID-19 pandemic, utilization of telemedicine has increased quickly for patient care and clinical trials. Unfortunately, teleconsultation is closer to a video conference than a medical consultation with the current solutions setting the patient and doctor into a discussion that relies entirely on a two-dimensional view of each other. A telehealth platform is augmented by a digital twin of the patient that assists with diagnostic testing of ocular manifestations of myasthenia gravis. A hybrid algorithm combines deep learning with computer vision to give quantitative metrics of ptosis and ocular muscle fatigue leading to eyelid droop and diplopia. The system works both on a fixed image and video in real time allowing capture of the dynamic muscular weakness during the examination. The robustness of the system can be more important that the accuracy obtained in controlled conditions, so that the system and method can operate in practical standard telehealth conditions. The approach is general and can be applied to many disorders of ocular motility and ptosis.
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
G06V 40/18 - Eye characteristics, e.g. of the iris
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
41 - Education, entertainment, sporting and cultural services
Goods & Services
Clothing, namely, shirts, collared shirts Paper notebooks; desktop business card holders; pens; pen holders; stickers; pencil; paper weights; gift bags; bookends Tote bags, umbrellas Insulated sports water bottles, ceramic mugs Educational services, namely, providing instruction and training at the undergraduate, graduate and postgraduate levels; providing a website featuring information on university academic programs
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
41 - Education, entertainment, sporting and cultural services
Goods & Services
Clothing, namely, shirts, collared shirts Paper notebooks; desktop business card holders; pens; pen holders; stickers; pencil; paper weights; gift bags; bookends Tote bags, umbrellas Insulated sports water bottles, ceramic mugs Educational services, namely, providing instruction and training at the undergraduate, graduate and postgraduate levels; providing a website featuring information on university academic programs
9.
SYSTEMS AND METHODS FOR CYTOCAPTURE OF IMMUNE CELLS TO DETECT INTERNAL INFECTIONS
The present technology detects immune cell activation. In certain embodiments, the system has a polymer block with a reaction chamber having an optically clear light path and fluidic connections to a device having a microcontroller in communication with electromagnets, air pumps, valves, an LED light source, and a photosensor. The polymer block is able to receive a blood sample in media comprising antibody coated beads.
Disclosed herein are compositions for use in and methods of producing HDAC11-activated macrophages. Also disclosed herein are methods of treating inflammation and providing adaptive cell therapy comprising HDAC11-activated M2 macrophages.
A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Disclosed herein are nucleic acid molecules, viral vectors, plasmids, and pharmaceutical formulations for use as effectors in methods of maturing iPSC-CMs. Disclosed herein are methods of maturing iPSC-CMs.
A plenoptic, or light field, imaging enables the reconstruction of the light field, and therefore of a 3D scene, from a single camera through computational imaging. The plenoptic approach is an improvement to Fourier integral microscopy, or FIMic, to macroscopic imaging. The plenoptic imaging scheme offers better spatial resolution and simpler calibration and many generic computational reconstruction schemes. The plenoptic system does not require a complex customization of a camera, but instead relies on the design of a camera objective, which greatly reduces the complexity and cost of the scheme and simplifies its deployment to many cameras.
H04N 23/957 - Light-field or plenoptic cameras or camera modules
G02B 15/20 - Optical objectives with means for varying the magnification by axial movement of one or more lenses or groups of lenses relative to the image plane for continuously varying the equivalent focal length of the objective with interdependent non-linearly related movements between one lens or lens group, and another lens or lens group having an additional movable lens or lens group for varying the objective focal length
G06T 15/00 - 3D [Three Dimensional] image rendering
H04N 23/12 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from different wavelengths with one sensor only
13.
SYSTEM AND METHOD FOR NANOSCALE AXIAL LOCALIZATION AND SUPER RESOLUTION AXIAL IMAGING WITH HEIGHT-CONTROLLED MIRROR
Systems and methods for microscopic imaging include an inverted microscope directed at a sample on a coverglass, where the sample is comprised of one or more cells and one or more chromophores. A ridge separates the coverglass from a silicon dioxide layer, and a silicon mirror is situated on the silicon dioxide layer, opposite the ridge and coverglass, while a weight is situated against the silicon mirror, opposite the silicon dioxide layer. The inverted microscope uses a spatial light modulator to diffract light through a linear polarizer and a filter wheel comprised of one or more Fourier filters. A beam or beams of s-polarized light is directed to the silicon mirror to create axial light modulation with its reflection on the silicon mirror, producing image data that is captured at a light detector.
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
Inventor
Kumar, Nirbhay
Holeski Hayashi, Clifford Thomas
Cao, Yi
Weissman, Drew
Abstract
Disclosed herein are methods inducing an antigen specific immune response, methods of interrupting malaria transmission, and methods of treating and/or preventing malaria. Disclosed herein are mRNA molecules, viral vectors, mRNA vaccines, and pharmaceutical formulations for use in the disclosed methods.
A method and system of real-time determination of control parameters for generating a plasma jet with a specific chemical composition is disclosed. The system includes a controller coupled to a gas source and a voltage source to generate a plasma jet having the desired chemical composition via control parameters for the gas and voltage. An optical emission spectroscopy sensor detects spectral data from the plasma jet. A diagnostic neural network module is trained to output chemical compositions and energy distribution of gasses of the gas source from an input of spectral data. The detected spectral data is input to the diagnostic neural network. A control neural has an input of the chemical compositions and energy distribution output by the diagnostic neural network and an output of the control parameters. The control neural network is trained via chemical compositions output from the diagnostic neural network and the desired chemical composition.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
16.
BIORESORBABLE CARDIOVASCULAR INSTRUMENTS, AND OPERATION AND FABRICATION METHODS OF SAME
A device implantable on a target of interest of a subject for pacemaker, neuromodulator, and/or defibrillator therapy comprises a wireless power harvesting unit configured to deliver power via resonant inductive coupling to the target tissue for stimulation in a manner that eliminates need for batteries and allows for externalized control without transcutaneous leads. The device relies exclusively on materials that resorb when exposed to biofluids in a time-controlled manner via metabolic action and hydrolysis. The materials and design choices create a thin, flexible, and lightweight form that maintain excellent biocompatibility and stable function throughout a desired period of use. Over a subsequent timeframe following the completion of therapy, the devices disappear completely through natural biological processes. These characteristics and a miniaturized geometry facilitate full implantation into the body to eliminate the need for percutaneous hardware, which thereby minimizes the risk of device-associated infections and dislodgement.
The present disclosure relates to novel compounds useful as antimicrobial agents. The present disclosure also relates to processes for their preparation, pharmaceutical compositions comprising them, and to their use in methods for treating or preventing microbial infections caused by parasites or bacteria, such as, for example, Plasmodium falciparum or related Plasmodium parasite species, Mycobacterium tuberculosis or related Mycobacterium bacteria species, S aureus, and ESKAPE pathogens.
A01N 57/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups , , , containing acyclic or cycloaliphatic radicals
The present disclosure relates to novel compounds useful as antimicrobial agents. The present disclosure also relates to processes for their preparation, pharmaceutical compositions comprising them, and to their use in methods for treating or preventing microbial infections caused by parasites or bacteria, such as, for example, Plasmodium falciparum or related Plasmodium parasite species, Mycobacterium tuberculosis or related Mycobacterium bacteria species, S. aureus, and ESKAPE pathogens.
A sensor has a surface acoustic wave (SAW) generator with an input and an output forming a SAW wave therebetween. A 2D material assembly is positioned between the input and output of the SAW generator. The 2D material assembly including a 2D material, whereby the SAW wave increases the sensitivity of the 2D material. A sensor array includes a plurality of sensors, each with a different 2D material.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Healthcare; Healthcare services, namely, integrated healthcare services with a network of healthcare providers; Healthcare offered through an organization of healthcare providers that correlates reimbursements with quality metrics and reductions in cost of care for an assigned group; Healthcare in the nature of providing in-person and online-based clinical management of disease treatment programs, wellness programs and geriatric health care management services as well as strategies related thereto for managing individual's health; Hospital services; Medical services; Medical services in the fields of general practice, allergies, anesthesiology, anorexia and bulimia, audiology, bariatric rehabilitation patient care services, bariatric surgery, bloodless medicine medical services, breast care, breast oncology, breast surgery, breath and lung diseases and disorders, cardiology, clinical mental health counseling, electrophysiology, endovascular medical services, autism, autoimmune diseases, cystic fibrosis, dermatology, diabetes, endocrinology, epilepsy, fertility, gastroenterology, genetics, geriatrics and palliative care, hematology, hepatology, hypertension, immunology, infectious diseases, obstetrics and gynecology, orthopedics, neonatology, nephrology, neurology, neuroscience, nutrition, obesity, oncology, ophthalmology, optometry, orthopedics, otolaryngology, pathology, pain management, pancreatitis, pediatrics, plastic surgery, podiatry, preventive medicine, psychiatry and behavioral medicine, pulmonology, radiology, rheumatology, urgent care, urology, virology, imaging and radiology, vein treatment, voice treatment, weight loss, and surgery of all types; Medical care; Medical counseling; Managed health care services; Managed health care services, namely, providing wellness services, namely, personal health assessments, health maintenance schedules and routines; Providing information in the fields of health and wellness to consumers and physicians, hospitals and other health care providers
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Healthcare; Healthcare services, namely, integrated healthcare services with a network of healthcare providers; Healthcare offered through an organization of healthcare providers that correlates reimbursements with quality metrics and reductions in cost of care for an assigned group; Healthcare in the nature of providing in-person and online-based clinical management of disease treatment programs, wellness programs and geriatric health care management services as well as strategies related thereto for managing individual's health; Hospital services; Medical services; Medical services in the fields of general practice, allergies, anesthesiology, anorexia and bulimia, audiology, bariatric rehabilitation patient care services, bariatric surgery, bloodless medicine medical services, breast care, breast oncology, breast surgery, breath and lung diseases and disorders, cardiology, clinical mental health counseling, electrophysiology, endovascular medical services, autism, autoimmune diseases, cystic fibrosis, dermatology, diabetes, endocrinology, epilepsy, fertility, gastroenterology, genetics, geriatrics and palliative care, hematology, hepatology, hypertension, immunology, infectious diseases, obstetrics and gynecology, orthopedics, neonatology, nephrology, neurology, neuroscience, nutrition, obesity, oncology, ophthalmology, optometry, orthopedics, otolaryngology, pathology, pain management, pancreatitis, pediatrics, plastic surgery, podiatry, preventive medicine, psychiatry and behavioral medicine, pulmonology, radiology, rheumatology, urgent care, urology, virology, imaging and radiology, vein treatment, voice treatment, weight loss, and surgery of all types; Medical care; Medical counseling; Managed health care services; Managed health care services, namely, providing wellness services, namely, personal health assessments, health maintenance schedules and routines; Providing information in the fields of health and wellness to consumers and physicians, hospitals and other health care providers
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Healthcare; Healthcare services, namely, integrated healthcare services with a network of healthcare providers; Healthcare offered through an organization of healthcare providers that correlates reimbursements with quality metrics and reductions in cost of care for an assigned group; Healthcare in the nature of providing in-person and online-based clinical management of disease treatment programs, wellness programs and geriatric health care management services as well as strategies related thereto for managing individual's health; Hospital services; Medical services; Medical services in the fields of general practice, allergies, anesthesiology, anorexia and bulimia, audiology, bariatric rehabilitation patient care services, bariatric surgery, bloodless medicine medical services, breast care, breast oncology, breast surgery, breath and lung diseases and disorders, cardiology, clinical mental health counseling, electrophysiology, endovascular medical services, autism, autoimmune diseases, cystic fibrosis, dermatology, diabetes, endocrinology, epilepsy, fertility, gastroenterology, genetics, geriatrics and palliative care, hematology, hepatology, hypertension, immunology, infectious diseases, obstetrics and gynecology, orthopedics, neonatology, nephrology, neurology, neuroscience, nutrition, obesity, oncology, ophthalmology, optometry, orthopedics, otolaryngology, pathology, pain management, pancreatitis, pediatrics, plastic surgery, podiatry, preventive medicine, psychiatry and behavioral medicine, pulmonology, radiology, rheumatology, urgent care, urology, virology, imaging and radiology, vein treatment, voice treatment, weight loss, and surgery of all types; Medical care; Medical counseling; Managed health care services; Managed health care services, namely, providing wellness services, namely, personal health assessments, health maintenance schedules and routines; Providing information in the fields of health and wellness to consumers and physicians, hospitals and other health care providers
23.
ICEPHOBIC SURFACES AND METHODS OF PRODUCING THE SAME
An icephobic substrate includes a base substrate and an icephobic coating on a first surface of the base substrate, the icephobic coating comprising nanoparticles on the first surface of the substrate, carbon nanotubes bound to the nanoparticles, and fluorinated polyhedral oligomeric silsesquioxane (POSS) compounds impregnated into and/or onto the carbon nanotubes, wherein the icephobic substrate has a plurality of flowpaths for the movement of solids and/or liquids relative to the icephobic coating.
C08G 77/24 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen halogen-containing groups
24.
3D PRINTING OF BIOMIMETIC FLEXIBLE MULTILAYER BLOOD VESSELS
Systems and methods for producing artificial blood vessels. In certain embodiments, the method for producing blood vessels includes printing an elastic outer layer and removing polyvinyl alcohol component from the elastic outer layer. The process then involves forming a first inner layer of smooth muscle cells, wherein the smooth muscle cells are mixed with 5 fibrinogen solution and extruded with thrombin to form a smooth muscle cell gel, and forming a second inner layer of endothelial cells, wherein the endothelial cells are mixed with fibrinogen solution and extruded with thrombin to form an endothelial cell gel.
Disclosed herein are compositions for and methods of directing evolution of biomolecules. The disclosed methods simplify traditional error prone PCR of a single or multiple genes expressed on plasmid DNA for directed evolution and remove several previously required molecular biology steps, thereby affording facile purification of plasmid DNA expressing biomolecules directly from mammalian cells.
A reactor for use with a media and a standard microtiter well plate having a transparent bottom, and a target substance at the bottom of the well, a support layer with a lower surface that extends substantially parallel to the top surface of the well plate, a perfusion plug extending outward from the lower surface of said support layer which has a distal end that is at a distance from the bottom of the well to form a bottom flow channel at the bottom portion of the well, an inlet channel extending through the support layer and through or around the perfusion plug and in fluid communication with the bottom flow channel, an outlet channel extending through said support layer and through or around the perfusion plug and in fluid communication with the bottom flow channel, media travelling from the inlet channel, through the bottom flow channel, to the outlet.
A plasma thruster has a tunable electron source configured to provide electrons with controllable energy. An entry electrode and an exit electrode permit an air flow to pass from the entry electrode to the exit electrode. The entry electrode and exit electrode receive electrons from the tunable electron source. A controller selectively controls the entry and exit electrodes to accelerate positive and negative ions in the air.
A telehealth platform is augmented by a digital twin of the patient that assists with diagnostic testing of ocular manifestations of myasthenia gravis. A hybrid algorithm combines deep learning with computer vision to give quantitative metrics of ptosis and ocular muscle fatigue leading to eyelid droop and diplopia. The system works both on a fixed image and video in real time allowing capture of the dynamic muscular weakness during the examination. The robustness of the system can be more important that the accuracy obtained in controlled conditions, so that the system and method can operate in practical standard telehealth conditions. The approach is general and can be applied to many disorders of ocular motility and ptosis
Embodiments of the instant disclosure relate to compositions and methods of use thereof that allow for faster integration of acute cardiac pacing experiments compared to the direct genetic modification methods currently in use. Embodiments provided herein provide for spheroids that may be stored, transported, and deployed on site to confer optical pacing of cardiac tissue for use in high-throughput functional in vitro screening assays.
The present invention relates to an integrated electrochemical lithium extraction process to directly produce lithium hydroxide from geothermal brine. The process integrates electrochemical silica removal, selective uptake and release of lithium using an intercalation material, and electro-driven generation of hydroxy (OH-) ions.
A hardware framework for cyber-deception operations provides flexibility in formulating counterattacks and leverages hardware support for efficiency. Hardware-assisted deception primitives are provided at kernel crossing boundaries to privileged system features that propel the security defenses to dynamically manipulate the malware execution and present a deceptive view of the system state to the attackers. Malware may be in the form of various attack vectors including ransomware, infostealers, buffer overflow, and side-channels.
G06F 21/54 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by adding security routines or objects to programs
G06F 21/56 - Computer malware detection or handling, e.g. anti-virus arrangements
32.
TWO-DIMENSIONAL MATERIAL PRINTER AND TRANSFER SYSTEM
A material transfer system transfers 2-dimensional (2D) material to or from a substrate. The system comprises a transfer apparatus having a transfer material holder for retaining a transfer material, and a stamping apparatus having an intermediate portion with a longitudinal axis and a distal end portion. The distal end portion has a proximal section, middle section and distal section forming a distal end face. The middle section is curved with respect to the longitudinal axis to form a stamper contact surface at the middle section. The stamper contact is surface configured to contact the transfer material.
A photovoltaic receiver includes a string of photovoltaic cells that includes at least two photovoltaic cells, where the at least two photovoltaic cells are coupled to one another in series. The string of photovoltaic cells has rotational symmetry with respect to a reference point. The photovoltaic receiver further includes an energy storage element for a photovoltaic cell of the string of photovoltaic cells and being coupled to the photovoltaic cell of the string of photovoltaic cells in parallel.
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
Inventor
Millar, Richard C.
Meyer, Robert Walter
Abstract
The operation of multiple unmanned vehicles (UAV) commanded and supported by a manned "Tender" air vehicle carrying a pilot and flight manager(s). The "Tender" is equipped to flexibly and economically monitor and manage multiple diverse UAVs over otherwise inaccessible terrain through wireless communication. The architecture enables operations and analysis enabled by means to detect, assess and accommodate change and hazards on the spot with effective human observation and coordination. Further, the optimal trajectories for UAVs to collect data from sensors in a predefined continues space. The system formulates the path-planning problem for a cooperative, and homogeneous swarm of UAVs tasked with optimizing multiple objectives simultaneously as its objectives are maximizing accumulated data within a given fly time and designed data clouding processing constraints as well as minimizing the probable imposed risk during UAVs mission. The risk assessment model determines risk indicators using an integrated SORA-BBN (the Specific Operation Risk Assessment - Bayesian Belief Network) approach while its resultant analysis is weighted through AHP ranking model. To this end, as the problem is formulated as a convex optimization model, therefore, the system has a low complexity Multi-objective reinforcement (MORL) algorithm with a provable performance guarantee to solve the problem efficiently. The MORL architecture is successfully trained and allow each UAV to map each observation of the network state to an action to make optimal movement decisions. This network architecture enables the UAVs balance multi objectives. Estimated MSE measures show that the introduced algorithm followed decreasing error in learning process with the increase in the epoch number.
A hyper-excitation hyperspectral imaging (HE-HSI) system. The system represents a technology-empowered expansion of spectroscopy into the imaging domain. The system includes optical components such as tunable filters, light sources, hyperspectral cameras, and advanced data processing algorithms. The HE-HSI system collects information across the entire UV10 VIS-IR range by collecting both excitation and emission data from each pixel of an image. HEHSI yields a computationally rich 4D data array that includes both fluorescence and reflectance profiles.
G01N 21/33 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01J 3/30 - Measuring the intensity of spectral lines directly on the spectrum itself
G01J 3/40 - Measuring the intensity of spectral lines by determining density of a photograph of the spectrumSpectrography
Systems and methods are disclosed for a method of production of carbon nanochain, for use as cathodes, either alone or in combination with multi-walled carbon nanotubes. The carbon nanochain precursors are heated in the presence of inert atmosphere to synthesize the carbon nanochains. The carbon nanochains have high gravimetric and volumetric capacity and good cycle life when used as cathodes in Li—O2 batteries. The performance of Li—O2 battery cathodes comprised of mixtures of carbon nanochains and multiwalled carbon nanotubes is dramatically improved relative to cathodes comprised of either material in the absence of the other.
The present disclosure generally relates target cancer cell specific immunotherapy compositions, methods of making and use thereof. Also provided in the disclosure are methods of treating a cancer in a subject in need thereof.
Aspects of this disclosure are directed to optical probes for collecting images of a region of interest for determining wall shear stress. The optical probe includes an imager with a line of sight and a light guide configured to steer light from a light source to the region of interest. The optical probe includes an objective configured to focus light reflected off of the region of interest to the line of sight of the imager. The optical probe can include a micro-lens array at the objective. The micro-lens array can focus light from the objective onto the imager. The imager can collect images from the light from the micro-lens array for determining wall shear stress at the region of interest.
A thruster has a first stage and a second stage. The first stage is a plasma source that outputs a plasma. The second stage is an accelerator. In one embodiment, the second stage is a plasma accelerator that accelerates the plasma. In another embodiment, the second stage is an ion accelerator that accelerates the ions from the plasma.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
A wearable includes: a mechanical amplifier; a first acoustic transducer positioned to sense acoustic signals from a target surface and amplified by the mechanical amplifier, the first acoustic transducer configured to generate a first set of electrical signals based on the sensed acoustic signals; a second acoustic transducer offset from the first acoustic transducer and positioned to sense ambient acoustic noise, the second acoustic transducer configured to generate a second set of electrical signals; a microcontroller coupled to the first and second acoustic transducers; and a transmitter coupled to the microcontroller. The microcontroller is configured to prepare a data set based on a digitized version of the first and second sets of electrical signals. The transmitter is configured to: receive the data set from the microcontroller; and transmit the data set to another device.
Among the various aspects of the present disclosure is the provision of devices, systems, and methods for tracking the positions and orientations of at least one bone screw implanted within a surgical site. The disclosed device includes an extension that includes an extension base configured to couple to the bone screw, a marker arm coupled at one end to the extension base in a hinged arrangement, and an optical marker attached to a free end of the marker arm opposite the hinged attachment. The optical marker includes a pair of lenticular arrays in a coplanar arrangement in which the major axes of the lenticular arrays are mutually perpendicular. Each lenticular array is configured to display different hues at different viewing angles. The disclosed method includes transforming a single image of a surgical site containing at least one bone screw and extension into the global positions of each bone screw based on the pixel positions and hues corresponding to the lenticular arrays of each optical marker.
A61B 17/58 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Precise nerve detection during surgery is crucial for safe operational outcomes, which largely depend on the surgeon's skills. Therefore, automatic real-time identification of anatomical structures is of great importance. However, image processing times must be kept as low as possible to be a viable solution for real-time visual identification. By using a general purpose graphics processing unit (GPGPU) implementation for birefringence mapping, the process can achieve rates of 43 frames per second (FPS); a 118x gain from a CPU implementation. Furthermore, by including a deep learning network, the complete framework can automatically detect nerves close to 12 FPS. By leveraging GPU for the processing task, the framework can run on compact devices with NVIDIA modules, such as Jetson Xavier AGX, while still achieving reasonably fast nerve identification and visualization.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
An electronic system for multimodal diagnostic measurements and therapeutic interventions includes a plurality of element network layers vertically stacked one with another on a flexible substrate, each element network layer being bi-axially stretchable and comprising a plurality of elements configured in an addressable, interconnected array formed in a multilayered structure and operably performing a distinct function. The electronic system is a multimodal, multiplexed soft electronic system in a multilayered configuration that supports capabilities ranging from high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters, to options in programmable high-density actuation of thermal inputs and/or electrical stimulation, drug elution, radio frequency ablation, and/or irreversible electroporation ablation.
Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A transient closed-loop system for cardiac pacing and/or defibrillator therapy for a subject includes a bioresorbable module configured to at least partially attach to an epicardial interface of the subject's heart for the cardiac pacing; at least one skin-interfaced module configured to attach to an outer surface of the subject's skin, wherein the bioresorbable module is in wireless communication with the at least one skin-interfaced module; and a control module in wireless communication with the at least one skin-interfaced module.
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Paper notebooks; stickers; decals; stationery; pens; pencils; pen holders; paper weights; desktop business card holders; bookends; writing paper; gift bags; printed calendars; printed posters; letter openers; adhesive note paper; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holder in the nature of card cases Insulated sports water bottles sold empty; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner drinking glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Cloth pennants; blanket throws Clothing, namely, pants and shirts; clothing, namely, caps, hats, knitted caps, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirts, short-sleeve shirts, long-sleeve shirts, polo shirts, tank tops, tee shirts, t-shirts, shirts for infants, babies, toddlers and children, shorts, neckties, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves and socks; women's clothing, namely, dresses, skirts and blouses; athletic apparel, namely, sports shirts, athletic shirts, pants, jackets, footwear, athletic uniforms, baseball caps and swim caps Retail book store and Retail store services featuring a wide variety of consumer goods of others; on-line retail book store and On-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; Association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; Arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; organizing and conducting college sport competitions and athletic events; providing collegiate athletic and sporting events; career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
The present disclosure relates to a process for preparing long-chain alkanes and alkenes from alcohols, aldehydes, or both. The process proceeds via acceptorless dehydrogenation and decarbonylative coupling using a supported catalyst.
C07C 1/24 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms by elimination of water
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Paper notebooks; stickers; decals; stationery; writing paper; writing pads; writing pad holders; pens; pencil; pen holders; paper weights; desktop business card holders; bookends; gift bags; printed calendars; desk pads; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Cloth pennants; blanket throws Clothing, namely shirts and pants; clothing, namely, caps, hats, knitted caps, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirts, short-sleeve shirts, long-sleeve shirts, polo shirts, tank tops, tee shirts, t-shirts, shirts for infants, babies, toddlers and children, shorts, neckties, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves and socks; women's clothing, namely, dresses, skirts and blouses; athletic apparel, namely, sports shirts, athletic shirts, pants, jackets, footwear, athletic uniforms, baseball caps and swim caps Retail bookstore and retail store services featuring a wide variety of consumer goods of others; on-line retail book store and on-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; Recruitment of students for higher education institutions, namely, organizing and conducting law school admission fairs, by bringing together students and professionals interested in attending law school and representatives from law schools; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; organizing and conducting college sport competitions and athletic events; providing collegiate athletic and sporting events; career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Paper notebooks; stickers; decals; stationery; writing paper; writing pads; writing pad holders; pens; pencil; pen holders; paper weights; desktop business card holders; bookends; gift bags; printed calendars; desk pads; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Cloth pennants; blanket throws Clothing, namely, shirts and pants; clothing, namely, caps, hats, knitted caps, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirts, short-sleeve shirts, long-sleeve shirts, polo shirts, tank tops, tee shirts, t-shirts, shirts for infants, babies, toddlers and children, shorts, neckties, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves and socks; women's clothing, namely, dresses, skirts and blouses; athletic apparel, namely, sports shirts, athletic shirts, pants, jackets, footwear, athletic uniforms, baseball caps and swim caps Retail bookstore and retail store services featuring a wide variety of consumer goods of others; on-line retail book store and on-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; Recruitment of students for higher education institutions, namely, organizing and conducting law school admission fairs, by bringing together students and professionals interested in attending law school and representatives from law schools; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; organizing and conducting college sport competitions and athletic events; providing collegiate athletic and sporting events; career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Paper notebooks; stickers; decals; stationery; writing paper; writing pads; writing pad holders; pens; pencil; pen holders; paper weights; desk top business card holders; bookends; gift bags; printed calendars; desk pads; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Cloth pennants; blanket throws Clothing, namely, shirts and pants; clothing, namely, caps, hats, knitted caps, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirts, short-sleeve shirts, long-sleeve shirts, polo shirts, tank tops, tee shirts, t-shirts, shirts for infants, babies, toddlers and children, shorts, neckties, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves and socks; women's clothing, namely, dresses, skirts and blouses; athletic apparel, namely, sports shirts, athletic shirts, pants, jackets, footwear, athletic uniforms, baseball caps and swim caps Retail bookstore and retail store services featuring a wide variety of consumer goods of others; on-line retail book store and on-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; Recruitment of students for higher education institutions, namely, organizing and conducting law school admission fairs, by bringing together students and professionals interested in attending law school and representatives from law schools; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; organizing and conducting college sport competitions and athletic events; providing collegiate athletic and sporting events; career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Paper notebooks; stickers; decals; stationery; writing paper; writing pads; writing pad holders; pens; pencil; pen holders; paper weights; desktop business card holders; bookends; gift bags; printed calendars; desk pads; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Cloth pennants; blanket throws Clothing, namely, shirts and pants; clothing, namely, caps, hats, knitted caps, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirts, short-sleeve shirts, long-sleeve shirts, polo shirts, tank tops, tee shirts, t-shirts, shirts for infants, babies, toddlers and children, shorts, neckties, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves and socks; women's clothing, namely, dresses, skirts and blouses; athletic apparel, namely, sports shirts, athletic shirts, pants, jackets, footwear, athletic uniforms, baseball caps and swim caps Retail bookstore and retail store services featuring a wide variety of consumer goods of others; on-line retail book store and on-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; Recruitment of students for higher education institutions, namely, organizing and conducting law school admission fairs, by bringing together students and professionals interested in attending law school and representatives from law schools; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; organizing and conducting college sport competitions and athletic events; providing collegiate athletic and sporting events; career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Paper notebooks; stickers; decals; stationery; writing paper; writing pads; writing pad holders; pens; pencil; pen holders; paper weights; desktop business card holders; bookends; gift bags; printed calendars; desk pads; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Cloth pennants; blanket throws Clothing, namely, shirts and pants; clothing, namely, caps, hats, knitted caps, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirts, short-sleeve shirts, long-sleeve shirts, polo shirts, tank tops, tee shirts, t-shirts, shirts for infants, babies, toddlers and children, shorts, neckties, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves and socks; women's clothing, namely, dresses, skirts and blouses; athletic apparel, namely, sports shirts, athletic shirts, pants, jackets, footwear, athletic uniforms, baseball caps and swim caps Retail bookstore and retail store services featuring a wide variety of consumer goods of others; on-line retail book store and on-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; Recruitment of students for higher education institutions, namely, organizing and conducting law school admission fairs, by bringing together students and professionals interested in attending law school and representatives from law schools; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; organizing and conducting college sport competitions and athletic events; providing collegiate athletic and sporting events; career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Paper notebooks; stickers; decals; stationery; writing paper; writing pads; writing pad holders; pens; pencil; pen holders; paper weights; desktop business card holders; bookends; gift bags; printed calendars; desk pads; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Cloth pennants; blanket throws Clothing, namely, shirts and pants; clothing, namely, caps, hats, knitted caps, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirts, short-sleeve shirts, long-sleeve shirts, polo shirts, tank tops, tee shirts, t-shirts, shirts for infants, babies, toddlers and children, shorts, neckties, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves and socks; women's clothing, namely, dresses, skirts and blouses; athletic apparel, namely, sports shirts, athletic shirts, pants, jackets, footwear, athletic uniforms, baseball caps and swim caps Retail bookstore and retail store services featuring a wide variety of consumer goods of others; on-line retail book store and on-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; Recruitment of students for higher education institutions, namely, organizing and conducting law school admission fairs, by bringing together students and professionals interested in attending law school and representatives from law schools; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; organizing and conducting college sport competitions and athletic events; providing collegiate athletic and sporting events; career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
56.
CYBER-PHYSICAL SYSTEM TO ENHANCE USABILITY AND QUALITY OF TELEHEALTH CONSULTATION
A cyber-physical system for conducting a telehealth session. In embodiments, the system includes a hardware control box that enables patients (e.g., elderly or cognitively-impaired patients) to easily participate in the telehealth session. In some embodiments, the system analyzes sensor data (e.g., thermal images, eye tracking data, etc.) and calculates state variables that form a mathematical representation (a "digital twin") indicative of the physical, emotive, cognitive, or social state of the patient. In some of those embodiments, the system calculates Myasthenia Gravis core examination metrics by performing computer vision analysis on patient video data and/or audio analysis on patient audio data. In some embodiments, the system controls a pan-tile-zoom camera to zoom in on each region of interest that is relevant to the examination. In some embodiments, the digital twin is used as an input of a heuristic computer reasoning system, which uses artificial intelligence to support clinical diagnosis and decision-making.
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
57.
COMPOSITIONS FOR AND METHODS OF TREATING A SUBJECT HAVING INFLAMMATION
Disclosed herein are compositions for use in and methods of producing HDAC11-activated macrophages. Also disclosed herein are methods of treating inflammation and providing adaptive cell therapy comprising HDAC11-activated M2 macrophages.
A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (USA)
THE GEORGE WASHINGTON UNIVERSITY (USA)
Inventor
Zhang, Ningyan
An, Zhiqiang
Deng, Hui
Sun, Xiujie
Li, Rong
Abstract
The present disclosure relates to antibodies binding to tumor discoidin domain receptor 1 (DDR1) and the uses of the antibodies in detecting and treating cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
The present disclosure generally relates to classes of compounds that bind the chromo-barrel domain of AT-rich interactive domain 4B (ARID4B). In some aspects, the compounds are of the Formula (II) as described herein, or a diamine composite thereof as set forth in Formula III herein. In some aspects, the compound is selected from compounds 1a, 1b, 1c, 1d, 1e, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, (as described herein) or combinations thereof. The present disclosure further considers administration of the compounds to target ARID4B in cells and for the treatment of cancerous breast tissue cells.
A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
60.
MODIFIED NATURAL KILLER CELLS AND METHODS OF USING THE SAME
The disclosure provides modified NK cells and pharmaceutical compositions comrpsing the same. The disclosure also provides methods of treating cancer using the same.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
41 - Education, entertainment, sporting and cultural services
Goods & Services
Promoting public awareness of the need to improve food policy and to transform how we grow, distribute, consume, and think about food; public advocacy to promote new food production solutions; public policy consultancy services; providing public policy information in the field of food policy and food production solutions Educational services, namely, arranging and conducting training programs, classes, seminars, online non-downloadable webinars, workshops, conferences, and online courses in the field of food policy; providing online publications, namely, articles, books, magazines, bulletins, white papers, case studies, and reports in the field of food policy and food production solutions to hunger, poverty, public health, and the climate crisis
Multistate non-volatile photonic memory devices are disclosed. The photonic devices comprise phase change materials with broadband transparencies used to store discretized information with negligible losses in the 0 state. The photonic memories comprise multiple configurations for reading and writing multi-bit words. The reading mechanisms comprises schemes based on light-absorption (FIG. 1), shift in resonances of a cavity (ring resonator, photonic crystal; FIG. 2) or interferometric schemes (FIG. 3). The photonic memory devices employ multiple techniques for writing electrically (FIG. 4 and related performance) and/or all-optically (FIGS. 7-10). The optical writing can be performed with pulsed laser light coming either from free space or on-chip using dedicated writing lines and opportune drops.
Disclosed herein are compositions for and methods of directing evolution of biomolecules. The disclosed methods simplify traditional error prone PCR of a single or multiple genes expressed on plasmid DNA for directed evolution and remove several previously required molecular biology steps, thereby affording facile purification of plasmid DNA expressing biomolecules directly from mammalian cells.
Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with at least one biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.
A method of forming a surface texture includes arranging a flexible mask (610, 920) with a pattern over a surface (621) of a component (620); and performing electrochemical etching on the surface (621) of the component (620) to form a surface texture on the surface (621) according to the pattern of the flexible mask.
The present disclosure relates to improved processes for preparing modified lignite by reacting raw lignite with a source of magnesium (Mg2+) ions and a source of calcium (Ca2+) ions, washing the modified lignite (e.g., with water), drying, and pyrolyzing the treated lignite, and to the use of such products for phosphorous remediation.
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
Inventor
Kumar, Nirbhay
Hayashi, Clifford Thomas Holeski
Cao, Yi
Weissman, Drew
Abstract
Disclosed herein are methods inducing an antigen specific immune response, methods of interrupting malaria transmission, and methods of treating and/or preventing malaria. Disclosed herein are mRNA molecules, viral vectors, mRNA vaccines, and pharmaceutical formulations for use in the disclosed methods.
14 - Precious metals and their alloys; jewelry; time-keeping instruments
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
20 - Furniture and decorative products
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Cufflinks; Earrings; Jewelry; Necklaces; Watches Paper notebooks; stickers; decals; stationery; pens; pencils; pen holders; paper weights; desktop business card holders; bookends; writing paper; gift bags; printed calendars; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Picture frames; bulletin boards Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Blanket throws; Cloth pennants Clothing, namely, shirts and pants; Clothing, namely, caps, hats, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirt, tank tops, tee shirts, T-shirts, shorts, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves, socks, cloth bibs, infant wear; Athletic apparel, namely, shirts, pants, jackets, footwear, hats and caps, athletic uniforms Retail book store and Retail store services featuring a wide variety of consumer goods of others; on-line retail book store and On-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; Association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; Arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects. Organizing and conducting college sport competitions and athletic events; Providing collegiate athletic and sporting events; Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; Providing a website featuring entertainment information; Career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
14 - Precious metals and their alloys; jewelry; time-keeping instruments
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
20 - Furniture and decorative products
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Cufflinks; Earrings; Jewelry; Necklaces; Watches Paper notebooks; stickers; decals; stationery; pens; pencils; pen holders; paper weights; desktop business card holders; bookends; writing paper; gift bags; printed calendars; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Picture frames; bulletin boards Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Blanket throws; Cloth pennants Clothing, namely, pants and shirts; Clothing, namely, caps, hats, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirt, tank tops, tee shirts, T-shirts, shorts, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves, socks, cloth bibs, infant wear; Athletic apparel, namely, shirts, pants, jackets, footwear, hats and caps, athletic uniforms Retail book store and Retail store services featuring a wide variety of consumer goods of others; on-line retail book store and On-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; Association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; Arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Organizing and conducting college sport competitions and athletic events; Providing collegiate athletic and sporting events; Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; Providing a website featuring entertainment information; Career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities Hospital services; medical services; health care services; providing general health, wellness, and medical information to the public; providing educational information about disease management, health and wellness
14 - Precious metals and their alloys; jewelry; time-keeping instruments
16 - Paper, cardboard and goods made from these materials
18 - Leather and imitations of leather
20 - Furniture and decorative products
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Cufflinks; Earrings; Jewelry; Necklaces; Watches Paper notebooks; stickers; decals; stationery; pens; pencils; pen holders; paper weights; desktop business card holders; bookends; writing paper; gift bags; printed calendars; printed posters; letter openers; adhesive paper notes; paper name badges Athletic bags; overnight bags; tote bags; umbrellas; wallets; business card holders in the nature of card cases Picture frames; bulletin boards Insulated sports water bottles; decorative plates; decorative bowls; pewter tankards; ceramic tankards; ceramic mugs; plastic mugs; ceramic vases; insulating sleeve holders for beverage cans; pilsner glasses; tumblers for use as drinking glasses; shot glasses; drinking glasses Blanket throws; Cloth pennants Clothing, namely, shirts and pants; Clothing, namely, caps, hats, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirt, tank tops, tee shirts, T-shirts, shorts, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves, socks, cloth bibs, infant wear; Athletic apparel, namely, shirts, pants, jackets, footwear, hats and caps, athletic uniforms Retail book store and Retail store services featuring a wide variety of consumer goods of others; on-line retail book store and On-line retail store services featuring a wide variety of consumer goods of others; retail store services featuring merchandise bearing college or university logos, emblems or insignia; on-line retail store services featuring merchandise bearing college or university logos, emblems or insignia; Association services, namely, promoting the interests of a university and its alumni; association services, namely, promoting the interests of the membership of a university alumni association; association services, namely, promoting the interests of the alumni of a university through membership in an alumni association, organizing chapters of an alumni association and promoting the interests of the members thereof; Arranging and conducting special events for business purposes, namely, alumni events for business development, business networking, and professional networking purposes; providing employment counseling; providing information via the Internet to alumni and members and friends of a university regarding business networking and association services, namely, promoting the interests of the alumni of a university; charitable services, namely, organizing and conducting volunteer programs and community service projects Organizing and conducting college sport competitions and athletic events; Providing collegiate athletic and sporting events; Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on university academic programs; Providing information on attending college and university with an emphasis on newly enrolled students via a website; providing a website featuring information on university sports events and entertainment; Providing a website featuring entertainment information; Career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities Hospital services; medical services; health care services; providing general health, wellness, and medical information to the public; providing educational information about disease management, health and wellness
A system performing optical and/or electro-optical tensor operations and featuring a photonic dot product engine with a first input and a second input and summation to perform multiply-accumulate operations. The first and/or second input is a matrix, and/or a vector, and/or scalar. The system is a Photonic Tensor Core.
A satellite propulsion system and methods of operating the same include a first ionization stage and a second acceleration stage. The first ionization stage has a plasma source configured to produce an arc discharge and emit a preliminary plasma. The plasma source includes an external magnetic field configured to magnetize the arc discharge. The second acceleration stage has an accelerator positioned in series with the plasma source. The accelerator is configured to accelerate the preliminary plasma out through the accelerator, thereby creating an accelerated plasma flow. The application of an activation threshold voltage to the accelerator results in a surge in system performance parameters.
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (USA)
THE GEORGE WASHINGTON UNIVERSITY (USA)
Inventor
Zhang, Ningyan
An, Zhiqiang
Deng, Hui
Sun, Xiujie
Li, Rong
Abstract
The present disclosure relates to antibodies binding to tumor discoidin domain receptor 1 (DDR1) and the uses of the antibodies in detecting and treating cancer. Thus, in one aspect, the present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to DDR1. In certain embodiments, the antibody or antigen-binding fragment, when bound to DDR1, modulates the activity of DDR1, i.e., suppresses DDR1.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to one or more anticancer drugs, such as platinum-based chemotherapeutics.
C07D 311/02 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
Systems and methods for microscopic imaging include an inverted microscope directed at a sample on a coverglass, where the sample is comprised of one or more cells and one or more chromophores. A ridge separates the coverglass from a silicon dioxide layer, and a silicon mirror is situated on the silicon dioxide layer, opposite the ridge and coverglass, while a weight is situated against the silicon mirror, opposite the silicon dioxide layer. The inverted microscope uses a spatial light modulator to diffract light through a linear polarizer and a filter wheel comprised of one or more Fourier filters. A beam or beams of s-polarized light is directed to the silicon mirror to create axial light modulation with its reflection on the silicon mirror, producing image data that is captured at a light detector.
G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
G02B 7/182 - Mountings, adjusting means, or light-tight connections, for optical elements for prismsMountings, adjusting means, or light-tight connections, for optical elements for mirrors for mirrors
The present disclosure relates to microencapsulated friction modifiers additives used in lubricants or other solutions, to their preparation, and to the use thereof to improve fuel economy of the engines and machines by enhancing friction reduction and prolonging the friction reduction time period.
C10M 177/00 - Special methods of preparation of lubricating compositionsChemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes
C10M 169/04 - Mixtures of base-materials and additives
77.
SYSTEMS AND METHODS FOR TRIPLE-PARAMETRIC OPTICAL MAPPING
Systems and methods are disclosed for an optical mapping device. The device emits different wavelengths of light from a plurality of light sources to a cardiac tissue and passes the light through a lens, a first filter cube in the path of the light with a first light filter, a second light filter, and a third light filter. Light passing through the filters is recorded by three cameras that each record an indicator of cardiac physiology, which are mapped simultaneously by the device.
The present technology detects immune cell activation. In certain embodiments, the system has a polymer block with a reaction chamber having an optically clear light path and fluidic connections to a device having a microcontroller in communication with electromagnets, air pumps, valves, an LED light source, and a photosensor. The polymer block is able to receive a blood sample in media comprising antibody coated beads.
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
C12N 5/0787 - Granulocytes, e.g. basophils, eosinophils, neutrophils or mast cells
C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
41 - Education, entertainment, sporting and cultural services
Goods & Services
Clothing, namely, caps, hats, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirt, tank tops, tee shirts, T-shirts, shorts, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves, socks, cloth bibs, infant wear; Athletic apparel, namely, shirts, pants, jackets, footwear, hats and caps, athletic uniforms Organizing and conducting college sport competitions and athletic events; Providing collegiate athletic and sporting events; Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on education and in the field of entertainment; Career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
41 - Education, entertainment, sporting and cultural services
Goods & Services
Clothing, namely, caps, hats, sweatpants, sweatshirts, sweaters, collared shirts, non-collared shirt, tank tops, tee shirts, T-shirts, shorts, jackets, sleepwear, pants, rainwear, gloves, mittens, scarves, socks, cloth bibs, infant wear; Athletic apparel, namely, shirts, pants, jackets, footwear, hats and caps, athletic uniforms Organizing and conducting college sport competitions and athletic events; Providing collegiate athletic and sporting events; Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on education and in the field of entertainment; Career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
41 - Education, entertainment, sporting and cultural services
Goods & Services
Organizing and conducting college sport competitions and athletic events; Providing collegiate athletic and sporting events; Educational services, namely, providing post-secondary level courses, seminars, and lectures of instruction; Providing a website featuring information on education and in the field of entertainment; Career counseling to alumni and graduating students, namely, providing advice concerning education options to pursue career opportunities
82.
COMPOSITIONS AND METHODS FOR TREATMENT OF PLATINUM-BASED CHEMOTHERAPEUTIC RESISTANT TUMORS
Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to platinum-based chemotherapy. In certain embodiments, methods of treating tumors herein can include administering an effective amount of at least one ursolic acid derivative. In certain embodiments, methods of treating tumors herein can include administering an effective amount of at least one ursolic acid derivative in combination with at least one platinum-based chemotherapeutic separately or in a combination therapy. In some embodiments, methods of treating tumors disclosed herein can include screening and/or selecting a subject suitable for treatment on the basis of SENP1 tumor expression. In other embodiments, methods of treating tumors can include administering a composition disclosed herein to a subject, the composition having a combination of at least one ursolic acid derivative and at least one platinum-based chemotherapeutic.
C07C 233/58 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
C07C 235/74 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
C07C 235/88 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups further acylated
C07C 235/26 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
A device implantable on a target of interest of a subject for pacemaker, neuromodulator, and/or defibrillator therapy comprises a wireless power harvesting unit configured to deliver power via resonant inductive coupling to the target tissue for stimulation in a manner that eliminates need for batteries and allows for externalized control without transcutaneous leads. The device relies exclusively on materials that resorb when exposed to biofluids in a time-controlled manner via metabolic action and hydrolysis. The materials and design choices create a thin, flexible, and lightweight form that maintain excellent biocompatibility and stable function throughout a desired period of use. Over a subsequent timeframe following the completion of therapy, the devices disappear completely through natural biological processes. These characteristics and a miniaturized geometry facilitate full implantation into the body to eliminate the need for percutaneous hardware, which thereby minimizes the risk of device-associated infections and dislodgement.
The disclosure provides for cryopreservation compositions and methods of use thereof. Aspects of the present disclosure provide for cryopreservation compositions useful in the freezing and thawing of cell therapies. Other aspects of the present disclosure provide for systems for use in the cryopreservation cell therapies. Still other aspects of the present disclosure provide for methods of cryopreserving cell therapies.
A photonic device that includes two electrodes and a two-dimensional (2D) material electrically connecting the two electrodes. The 2D material may be molybdenum ditelluride. Strain may be induced in the 2D material (e.g., by placing the 2D material on a waveguide) to reduce the band gap of the 2D material and increase the efficiency of the photodetector. The photonic device may be a photodetector with 2D material that absorbs light energy and converts it into a photocurrent in a circuit that includes the two electrodes. The photonic device may be an emitter with 2D material that emits light energy in response to an electric field across the two electrodes. The photonic device may be a modulator with 2D material that modulates a property of an optical signal (e.g., the amplitude or phase) by modulating the amount of strain induced in the 2D material.
Embodiments of the instant disclosure relate to compositions and methods of use thereof that allow for faster integration of acute cardiac pacing experiments compared to the direct genetic modification methods currently in use. Embodiments provided herein provide for spheroids that may be stored, transported, and deployed on site to confer optical pacing of cardiac tissue for use in high-throughput functional in vitro screening assays.
Disclosed herein are methods for quantifying contact lens deposition. An example method may comprise disposing a contact lens sample in a fluid well. The example method may comprise disposing a volume of tear fluid in the well with the contact lens sample. The example method may comprise capturing pre-rinse images of the contact lens sample. The example method may comprise rinsing the contact lens sample. The example method may comprise capturing post-rinse images of the contact lens after the rinsing. The example method may comprise determining, using one or more of the tear images or the post-rinse images, a deposition metric. The example method may comprise outputting the deposition metric.
Embodiments of the instant disclosure relate to novel methods and compositions for distinguishing high-grade ductal carcinoma in situ (DCIS) from lower-grade DCIS in a breast tissue. Other embodiments of the instant disclosure provide for methods of administering one or more appropriate breast cancer treatment regimens to a subject diagnosed with high-risk DCIS.
Embodiments of the instant disclosure relate to novel methods and compositions for distinguishing high-grade ductal carcinoma in situ (DCIS) from low-grade DCIS in a breast tissue. Other embodiments of the instant disclosure provide for methods of administering one or more appropriate breast cancer treatment regimens to a subject diagnosed with high-risk DCIS.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to immune checkpoint inhibitors. In certain embodiments, compositions herein can have at least one nanoparticle formed of Prussian blue materials and, optionally, one or more CD137 agonists. In other embodiments, methods of treating tumors herein can include administering an effective amount of at least photothermal therapy agent in combination with at least one CD137 agonist separately or in a combination therapy/combination composition.
Systems and methods for producing artificial blood vessels. In certain embodiments, the method for producing blood vessels includes printing an elastic outer layer and removing polyvinyl alcohol component from the elastic outer layer. The process then involves forming a first inner layer of smooth muscle cells, wherein the smooth muscle cells are mixed with 5 fibrinogen solution and extruded with thrombin to form a smooth muscle cell gel, and forming a second inner layer of endothelial cells, wherein the endothelial cells are mixed with fibrinogen solution and extruded with thrombin to form an endothelial cell gel.
A method and system of sensitization of cancerous cells in a volume is disclosed. A plasma tube including a pair of electrodes coupled to a power supply is provided. The plasma tube generates a plasma jet between the electrodes. A controller is coupled to a power supply to control a discharge voltage to the electrodes to generate the plasma jet and direct an electro-magnetic field at the volume having cancerous cells and normal cells for a sufficient time to sensitize the cancer cells. A treatment device applies a treatment such as TMZ to the sensitized cancer cells after the cancer cells are sensitized by the electro-magnetic field.
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A method and system of real-time determination of control parameters for generating a plasma jet with a specific chemical composition is disclosed. The system includes a controller coupled to a gas source and a voltage source to generate a plasma jet having the desired chemical composition via control parameters for the gas and voltage. An optical emission spectroscopy sensor detects spectral data from the plasma jet. A diagnostic neural network module is trained to output chemical compositions and energy distribution of gasses of the gas source from an input of spectral data. The detected spectral data is input to the diagnostic neural network. A control neural has an input of the chemical compositions and energy distribution output by the diagnostic neural network and an output of the control parameters. The control neural network is trained via chemical compositions output from the diagnostic neural network and the desired chemical composition.
Johns Hopkins University, School of Medicine (USA)
Inventor
Mendelowitz, David
Polotsky, Vsevolod
Freire, Carla
Abstract
The present disclosure generally relates to compositions and methods of treating opioid-induced respiratory depression in a subject in need thereof, the method comprising administering leptin.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
A binary code similarity detection system that compares a target binary code to a source code by comparing the target binary code to a comparing binary generated by compiling the source code. Rather than using a comparing binary generated using a random or fixed compiling configuration, the system identifies the compiling configuration of the target binary code and compares the target binary code to a comparing binary generated using the same compiling configuration as the target binary code. The compiling configuration of the target binary code may be identified by a neural network (e.g., a graph attention network trained on attributed function call graphs of binary codes with known compiling configurations). The target binary code and the comparing binary may be compared using a graph neural network (e.g., a graph triplet loss network) that compares attributed control flow graphs of the of the target binary code and the comparing binary.
The present invention discloses a unique panel of gene transcripts down-regulated in patients with coronary artery disease (CAD). Methods and compositions for detecting CAD in patient blood samples are provided.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
100.
NANOPARTICLE-MEDIATED IMMUNE CELL MANUFACTURE AND USES THEREOF
The present disclosure generally relates target cancer cell specific immunotherapy compositions, methods of making and use thereof. Also provided in the disclosure are methods of treating a cancer in a subject in need thereof.
