Abstract

The present application relates to hyaluronic acid (HA) hydrogels comprising divalent cations and hyaluronic acid molecules cross-lined with the divalent cations, and uses thereof. The present application also relates to methods of preparing the HA hydrogels of the present application.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

A microfluidic assembly including at least one microfluidic device is provided herein. The microfluidic assembly can be applied for vascularizing multicellular aggregates such as 2D or 3D animal cells or tissue implanted in a matrix that is held within an aperture of the microfluidic device. The microfluidic device in the microfluidic assembly is connected to a primary circulation system, which allows establishment and maintenance of physiologically relevant pressure gradients across the aperture of the microfluidic device. The microfluidic apparatus allows for connection of living microvessels, such as human microvessels, to a pressurized microfluidic channel via a porous membrane, allowing support of multicellular aggregates for long term culture.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• F15C 1/04 - Means for controlling fluid streams to fluid devices, e.g. by electric signals
• F15C 1/06 - Constructional detailsSelection of specified materials

Abstract

The present disclosure relates to a MEA electrolyser comprising a cathodic compartment operating CO2 reduction reactions (CO2RR) of CO2 from a gaseous CO2-containing stream, an anodic compartment operating all-liquid organic oxidation reactions (OOR), an ionic exchange membrane in between. A CO2RR-OOR system can further include a gas-liquid separation unit in fluid communication with the anodic compartment to receive the anodic product mixture and separate gaseous CO2 from the anodic product mixture to produce a CO2-depleted liquid product stream and a recovered pure gaseous CO2 stream. The system can further include a recycle line in fluid communication with the gas-liquid separation unit to redirect the recovered pure gaseous CO2 stream to the cathodic compartment of the MEA electrolyser as a portion of the gaseous CO2-containing stream. The present disclosure also concerns a process for electrochemically converting the gaseous CO2-containing stream to multi-carbon products in such a MEA CO2RR-OOR electrolyser.

IPC Classes  ?

• C25B 3/26 - Reduction of carbon dioxide
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 9/70 - Assemblies comprising two or more cells
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

Described in this document is a process for making heat transfer devices such as cold plates. The cold plates can be made by 3-D printing a polymer substrate, applying thermal spraying deposition of metal over the substrate, dissolving the substrate for removal to form an enclosed flow region through for passage of heat transfer fluid. Molten metal droplets can be sprayed onto the substrate having a surface region comprising a water-soluble thermoplastic to form metal splats on the surface region at a splat temperature and surface properties such that the metal splats penetrate and interlock to form a solid metal coating adhered to the polymer substrate. A dissolvable substrate can facilitate removal by contacting with a solvent to form the enclosed flow region defined by metallic surfaces, and also can enable complex geometries and enhanced heat transfer performance without the need for extensive machining.

IPC Classes  ?

• C23C 4/18 - After-treatment
• B22D 23/00 - Casting processes not provided for in groups
• B22D 29/00 - Removing castings from moulds, not restricted to casting processes covered by a single main groupRemoving coresHandling ingots
• C23C 4/01 - Selective coating, e.g. pattern coating, without pre-treatment of the material to be coated
• C23C 4/02 - Pretreatment of the material to be coated, e.g. for coating on selected surface areas
• C23C 4/06 - Metallic material

Abstract

The present invention provides a method for near real-time high-resolution measurements of molecular (bio)markers selected from soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), Angiopoietin-1 (Ang-1), and Angiopoietin-2 (Ang-2) based on surface-enhanced Raman spectroscopy (SERS). Using these measurements, the invention provides a means of monitoring progression of sepsis.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Abstract

nnnn-propanol using the system.

IPC Classes  ?

• C25B 11/046 - Alloys
• C25B 3/26 - Reduction of carbon dioxide
• C25B 3/29 - Coupling reactions
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

This technology relates to polynucleotides comprising optimized FMR1 open reading frame (ORF) sequences, viral vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of FMR1, such as Fragile X syndrome (“FXS”).

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/86 - Viral vectors

Abstract

A phased antenna array is operable to generate a radio-frequency beam having a first beam angle. A converging lens adjusts the beam generated by the phased antenna array to output a first adjusted beam. A diverging lens adjusts the first adjusted beam to output a second adjusted beam having a second beam angle. The converging lens and the diverging lens are positioned relative to the phased antenna array such that the second beam angle is greater than the first beam angle, such that a scan range of the phased antenna array is increased.

IPC Classes  ?

• H01Q 21/00 - Antenna arrays or systems
• H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
• H01Q 25/00 - Antennas or antenna systems providing at least two radiating patterns

Abstract

Methods and devices for identifying a pulmonary function pattern for a subject. A time series of measurements is obtained using an oscillometer. The time series of measurements are processed using a trained machine learning model, which may include inputting the time series of measurements to a filter bank to produce a feature vector composed of a set of proportion of positive values, and inputting the feature vector to a classifier to select one of a plurality of lung function patterns for the feature vector. A classification decision is then based on the selected lung function pattern.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/087 - Measuring breath flow
• G06F 18/24 - Classification techniques
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 20/00 - Machine learning

Abstract

A fluidic wound dressing device comprises a branching network of fluidic channels connecting a single inlet port to a plurality of outlet ports in a biocompatible, treatment site-facing surface. The branching network enables the delivery of injected fluids containing therapeutic agents such as cells, drugs, antimicrobics, saline, and the like to the treatment site vis the outlet ports with a substantially uniform distribution. The outlet ports may be arranged in a regular grid array or other arrangement of substantially consistent density. The branching network may be based on a fractal arrangement such as an H-network to provide channels of substantially equal length connecting the inlet with each outlet. The relative cross-sectional areas of the channels may be determined in accordance with Murray's law to provide for optimal fluid delivery. The device may be used to deposit hydrogels comprising therapeutic cells such as fibroblasts and keratinocytes in layered structures.

IPC Classes  ?

• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
• A61F 13/40 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators having means integral therewith for supplying media to the absorbent material, e.g. contained in a rupturable reservoir
• A61K 35/33 - Fibroblasts
• A61K 35/36 - SkinHairNailsSebaceous glandsCerumenEpidermisEpithelial cellsKeratinocytesLangerhans cellsEctodermal cells
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The present disclosure provides a method of fabrication of physically crosslinked polyimide (PCPI) aerogels with significantly improved properties using no chemical crosslinker. The fabricated PCPI aerogels present high moisture resistance, hydrophobic behavior, ultralow density, ultrahigh porosity, excellent thermal stability, increased mechanical strength, and high mechanical flexibility. Also, samples have been successfully fabricated in a thin-film geometry with high mechanical flexibility and controlled thickness. Furthermore, some fabricated aerogel films present improved optical transparency of over 80%, which is the highest transparency reported so far for organic PI aerogels.

IPC Classes  ?

• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules

Abstract

Multilayer cathodes for the electrochemical reduction of carbon dioxide as well as membrane electrode assemblies and bipolar membrane electrode assemblies comprising the multilayer cathodes are described. More particularly, the multilayer cathodes for the electrochemical reduction of carbon dioxide comprise a gas diffusion layer, a cathode catalyst layer disposed on the gas diffusion layer, and a permeable carbon dioxide regeneration layer comprising an anion exchange ionomer disposed on the cathode catalyst layer. The uses of the multilayer cathodes, the membrane electrode assemblies and the bipolar membrane electrode assemblies for the production of multicarbon products as well as their processes of manufacturing are also described. Finally, also described are methods for electrochemical production of a multicarbon product using the multilayer cathodes, the membrane electrode assemblies and the bipolar membrane electrode assemblies.

IPC Classes  ?

• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 3/07 - Oxygen containing compounds
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/032 - Gas diffusion electrodes
• C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
• C25B 13/02 - DiaphragmsSpacing elements characterised by shape or form
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

The present disclosure provides a method of fabrication of physically crosslinked polyimide (PCPI) aerogels with significantly improved properties using no chemical crosslinker. The fabricated PCPI aerogels present high moisture resistance, hydrophobic behavior, ultralow density, ultrahigh porosity, excellent thermal stability, increased mechanical strength, and high mechanical flexibility. Also, samples have been successfully fabricated in a thin-film geometry with high mechanical flexibility and controlled thickness. Furthermore, some fabricated aerogel films present improved optical transparency of over 80%, which is the highest transparency reported so far for organic PI aerogels.

IPC Classes  ?

• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08J 3/09 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids
• C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors

Abstract

Methods and devices for microfluidic porous membrane electrical cell-substrate impedance sensing (ECIS) are provided. Efficient methods of fabricating ECIS membrane electrodes as well as ECIS membrane electrodes having lower electrode resistance values, which allow for higher sensitivity measurements.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
• G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance

Abstract

An azide-containing cross-linker and method of preparing the same are provided. Such cross-linker can be used as an intermediate in a scalable production of a cross-linked hemoglobin protein having its beta subunits covalently linked to the azide-containing cross¬ linker. The present disclosure also pertains to a hemoglobin-based oxygen carrier (HBOC) comprising a pair of azide cross-linked hemoglobin proteins coupled by a copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) and a method for preparing the same. The HBOC may be used in a method for increasing oxygen transport or for use in transfusions or perfusions.

IPC Classes  ?

• A61K 35/14 - BloodArtificial blood
• A61K 38/42 - HaemoglobinsMyoglobins
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 7/08 - Plasma substitutesPerfusion solutionsDialytics or haemodialyticsDrugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 14/805 - HaemoglobinsMyoglobins
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08K 5/521 - Esters of phosphoric acids, e.g. of H3PO4

Abstract

Novel chimeric peptides comprise an N-cadherin binding domain for binding N-cadherin, which is expressed on the surface of cells, in particular smooth muscle cells, and a fibronectin-binding domain, which binds surrounding extracellular matrix and a binding site for fibronectin. The chimeric peptides can be loaded on to nanoparticles, suitably degradable polar hydrophobic ionic polyurethane (D-PHI) nanoparticles for delivery, which can be incorporated into coatings for medical devices, including stents and balloons.

IPC Classes  ?

• A61F 2/06 - Blood vessels
• A61F 2/07 - Stent-grafts
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61K 9/51 - Nanocapsules
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 19/00 - Hybrid peptides

Abstract

A linear double stranded deoxyribonucleic acid (dsDNA) molecule comprising operatively linked in 5′ to 3′ direction: a) one or more Ter sites at 5′ terminus (“5′ Ter”); b) a segment comprising a DNA sequence of interest; and c) one or more Ter sites at 3′ terminus (“3′ Ter). Also methods of protecting DNA sequences of interest from exonuclease degradation using the DNA constructs of the present disclosure, cells transformed with the DNA construct of the present disclosure and cell-free synthetic biology system comprising a linear dsDNA molecule of the present disclosure.

IPC Classes  ?

• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Provided herein is a method of decreasing a-syn levels and/or decreasing a-syn toxicity in a cell, the method comprising contacting the cell with a charged multivesicular body protein 2B: a-synuclein (CHMP2B:a-syn) inhibitor and a method of inhibiting neural degeneration, the method comprising administering to a subject in need thereof a charged multivesicular body protein 2B: a-synuclein (CHMP2B:a-syn) inhibitor.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

Systems and methods for aortic assessment are disclosed. Imaging data representing a four-dimensional (4D) flow are received. Upon processing the imaging data, kinetic energy of the flow at a first location of an aorta is estimated and kinetic energy of the flow at a second location downstream of the first location is also estimated. A loss metric measuring loss of kinetic energy from the first location to the second location is computed. A prediction of risk of aortic dissection based on at least the loss metric is generated.

IPC Classes  ?

• A61B 5/026 - Measuring blood flow
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06T 7/00 - Image analysis
• G06T 7/20 - Analysis of motion
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

Cryptographic processor chips, systems and associated methods are disclosed. In one embodiment, a cryptographic processor is disclosed. The cryptographic processor includes a first cryptographic processing module to perform a first logic operation. The first cryptographic processing module includes first input circuitry to receive ciphertext input symbols. A first pipeline stage performs a first operation on the ciphertext input symbols and generates a first stage output. On-chip memory temporarily stores the first stage output and feeds the first stage output to a second pipeline stage in a pipelined manner. The second pipeline stage is configured to perform a second operation on the first stage output in a pipelined manner with respect to the first pipeline stage.

IPC Classes  ?

• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems

Abstract

A device for regulating light passing through the device comprises a multi-layered stack. The stack comprises a first layer and a second layer. The first layer and the second layer allow the light to pass through the first layer and the second layer. A first fluid channel is defined between the first layer and the second layer. The first fluid channel allows the light to pass through the first fluid channel. A first fluid is operably received into the first fluid channel and operably withdrawn from the first fluid channel.

IPC Classes  ?

• E06B 3/67 - Units comprising two or more parallel glass or like panes in spaced relationship, the panes being permanently secured together, e.g. along the edges characterised by additional arrangements or devices for heat or sound insulation
• E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance

Abstract

222222R catalyst and the metallic COR catalyst are a metal-Sb compound comprising a metal and antimony, the antimony being atomically dispersed in a lattice formed by a crystalline structure of the metal.

IPC Classes  ?

• C25B 1/23 - Carbon monoxide or syngas
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 3/07 - Oxygen containing compounds
• C25B 3/25 - Reduction
• C25B 11/032 - Gas diffusion electrodes
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound

Abstract

A storage unit stores one of flow and distance matrices for an assignment problem having an evaluation function represented by a matrix operation of the flow and distance matrices, and a processing unit selects first and second entities from entities to be assigned to destinations, reads at least one first matrix element corresponding to the first and second entities from the stored flow or distance matrix, generates at least one second matrix element for the other of the flow and distance matrices, which is a patterned matrix, based on the first and second entities, calculates a change in the value of the evaluation function resulting from an assignment change of changing the destination of the first or second entity, using the first and second matrix elements, determines based on the change whether to allow the assignment change, and updates an assignment state when determining to allow the assignment change.

IPC Classes  ?

• G06F 17/16 - Matrix or vector computation
• G06F 17/11 - Complex mathematical operations for solving equations

Abstract

The present disclosure provides formulations of cannabinoid with advantages such as high drug-loading and stability, and related methods of manufacturing and using the formulations.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

There is described herein polyvalent HCV vaccines, preferably comprising SEQ ID Nos. 1-5. There is also described herein methods of designing polyvalent vaccines.

IPC Classes  ?

• A61K 39/29 - Hepatitis virus
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 40/30 - Unsupervised data analysis

Abstract

A system comprising a self-decarbonizing combustor and method of using the same are provided. The system comprises a combustor defining: a combustion chamber for combusting oxidizing agent and processed hydrocarbon. The combustor comprises an exhaust and a pyrolytic reactor which comprises a heating region and a separator. The heating region is defined within the combustion chamber for thermally coupling the heating region and the combustion chamber such that thermal energy generated in the combustion chamber is absorbed by the heating region to thermally decompose hydrocarbon feed. The separator is in fluid communication with the heating region for receiving hydrocarbon, where the separator is configured to pyrolyze the hydrocarbon and separate it into processed hydrocarbon and carbon black. The processed hydrocarbon is circulated to the combustion chamber for combustion and to heat the pyrolytic reactor. Carbon black may be removed from the separator as a separate product.

IPC Classes  ?

• C10G 31/06 - Refining of hydrocarbon oils, in the absence of hydrogen, by methods not otherwise provided for by heating, cooling, or pressure treatment
• B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds
• B01J 8/18 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles
• C01B 32/00 - CarbonCompounds thereof
• C10G 27/00 - Refining of hydrocarbon oils, in the absence of hydrogen, by oxidation
• F23K 5/08 - Preparation of fuel

Abstract

22 includes a reduction compartment comprising a cathode of a first electrolyser; an oxidation compartment comprising an anode of a second electrolyser; and an alternating redox compartment separated from the reduction compartment by a first cation exchange membrane of the first electrolyser and from the oxidation compartment by a second cation exchange membrane of the second electrolyser. The redox compartment receives an electrolyte solution comprising an organic redox-active molecule in fluid isolation of the reduction compartment. The redox compartment includes an alternating electrode serving as an anode of the first electrolyser for oxidation of the redox-active molecule in the redox compartment to facilitate regeneration of hydroxide capture solution in the reduction compartment, and as a cathode of the second electrolyser for reduction of the oxidized redox-active molecule to facilitate regeneration of an acidic neutralizing solution in the redox compartment.

IPC Classes  ?

• C25B 1/50 - Processes
• C07D 213/22 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07F 9/58 - Pyridine rings
• C25B 1/00 - Electrolytic production of inorganic compounds or non-metals

Abstract

There is provided a light-harvesting heterostructure for a photovoltaic device. The photovoltaic device includes at least an electron-transport layer and a hole-transport layer. The light-harvesting heterostructure includes a 3D perovskite material contacting one of the electron-transport layer and the hole-transport layer. The lightharvesting heterostructure also includes a 2D perovskite capping material extending over at least a portion of the 3D perovskite material and contacting another one of the electron-transport layer and the hole-transport layer. The 2D perovskite capping material includes one or more perovskite layers, each perovskite layer having a corresponding width n, wherein a majority of the corresponding width n is greater or equal to 3. The 2D perovskite capping material also includes a spacer extending between two subsequent perovskite layers.

IPC Classes  ?

• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/50 - Photovoltaic [PV] devices
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating

Abstract

Disclosed herein are methods for making a peptoid using green solvents such as ethyl acetate, DMSO and/or mixtures thereof. Methods using an acylation solvent that is DMSO or EtOAc or mixtures thereof as well as methods using an acylation wash solvent comprising DMSO wherein the DMSO is greater than 30% v/v are described.

IPC Classes  ?

• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 1/08 - General processes for the preparation of peptides using protecting groups or activating agents using activating agents
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides

Abstract

A process is provided using a single atom metal or semi-metal catalyst to photoreform abundant small molecule hydrogen vectors to produce hydrogen and a value-added by- product.

IPC Classes  ?

• C01B 3/02 - Production of hydrogen or of gaseous mixtures containing hydrogen
• B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
• B01J 32/00 - Catalyst carriers in general
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C01B 3/22 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds

Abstract

0.90.133). The light source used in the reaction has an intensity of at least 2 W cm-1. Processes for preparing copper substituted lanthanum manganese oxide perovskites for use as photocatalysts for dehydrogenation reactions are also disclosed.

IPC Classes  ?

• C07C 5/333 - Catalytic processes
• B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor

Abstract

A process for the production of hydrogen from a small molecule hydrogen vector by reforming such small molecule hydrogen vector under light in the presence of a light-absorbing carbon enabler.

IPC Classes  ?

• C01B 3/34 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents
• C01B 3/02 - Production of hydrogen or of gaseous mixtures containing hydrogen
• C01B 3/32 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air
• C10L 3/00 - Gaseous fuelsNatural gasSynthetic natural gas obtained by processes not covered by subclasses , Liquefied petroleum gas

Abstract

The present disclosure relates to combinations comprising an ATR inhibitor and a PARP inhibitor and optionally further comprising an additional pharmaceutically active agent. Also provided are certain methods of treatment, e.g., a method for treating cancer such as ovarian cancer, with a combination comprising an effective amount of an ATR inhibitor and an effective amount of a PARP inhibitor and optionally further comprising an additional pharmaceutically active agent. In particular, a combination comprising a liposomal composition of an ATR inhibitor and a liposomal composition of a PARP inhibitor is disclosed herein.

IPC Classes  ?

• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Abstract

A culture medium is provided for the maturation of pluripotent stem-cell derived cardiomyocytes. The culture medium contains a number of soluble factors, which can include putrescine, leukemia inhibitor factor and metformin.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

A co-formulation comprising: (i) an ionizable colloid forming active substance; (ii) a nucleic acid molecule; and (iii) an amphiphilic molecule. Also, a method of treating a disease or disorder comprising administering the co-formulation to a subject in need, wherein the ionizable colloid-forming active substance and the nucleic acid molecule included in the co-formulation act together in the treatment of the disease or disorder; and a method of manufacturing the co-formulation.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/51 - Nanocapsules
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present disclosure relates to an electrode for CO2 electroreduction in an acidic electrolyte comprising cation species, the electrode comprising: a substrate, a metal-based catalyst material, and a cation-augmenting material; wherein the cation-augmenting material comprises an acidic group exchanging protons with the cation species of the acidic electrolyte so as to increase a concentration of the cation species at a surface of the electrode.

IPC Classes  ?

• C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
• C25B 3/26 - Reduction of carbon dioxide
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 15/031 - Concentration pH

Abstract

A cathode catalyst for the electrochemical reduction of carbon monoxide and/or carbon dioxide is described. The cathode catalyst comprises a cathode catalyst layer and a nitrogen- and phosphorus- doped carbon coating layer disposed on the cathode catalyst layer. Also described is a membrane electrode assembly comprising the cathode catalyst. The use of the cathode catalyst and the membrane electrode assembly for the production of multicarbon products as well as their processes of manufacturing are also described. Finally, also described are methods for electrochemical production of a multicarbon product using the membrane electrode assembly.

IPC Classes  ?

• C25B 3/25 - Reduction
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/032 - Gas diffusion electrodes
• C25B 11/053 - Electrodes comprising one or more electrocatalytic coatings on a substrate characterised by multilayer electrocatalytic coatings
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25B 11/095 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one of the compounds being organic
• C25B 11/065 - Carbon
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials

Abstract

Methods and devices for microfluidic porous membrane electrical cell-substrate impedance sensing (ECIS) are provided. Efficient methods of fabricating ECIS membrane electrodes as well as ECIS membrane electrodes having lower electrode resistance values, which allow for higher sensitivity measurements.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G03F 7/16 - Coating processesApparatus therefor

Abstract

A light assisted photochemical process for converting carbonaceous materials and carbon dioxide to carbon monoxide under ambient operating conditions, and system therefor are disclosed.

IPC Classes  ?

• C01B 32/40 - Carbon monoxide
• B01J 19/24 - Stationary reactors without moving elements inside

Abstract

The present application provides methods for production of induced oligodendrocyte lineage cells (IOLCs) from donor astrocytes comprising contact the donor astrocytes with a polynucleotide comprising a nucleic acid encoding a single transcription factor (TF), wherein the single TF is Olig2, Sox10, or Nkx6.2. Also provided are pharmaceutical compositions for performing the method and associated uses thereof.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C12N 15/86 - Viral vectors

Abstract

Fully homomorphic encryption integrated circuit (IC) chips, systems and associated methods are disclosed. In one embodiment, a method of operation for a number theoretic transform (NTT) butterfly circuit is disclosed. The (NTT) butterfly circuit includes a high input word path cross-coupled with a low word path. The high input word path includes a first adder/subtractor, and a first multiplier. The low input word path includes a second adder/subtractor, and a second multiplier. The method includes selectively bypassing the second adder/subtractor and the second multiplier, and reconfiguring the low and high input word paths into different logic processing units in response to different mode control signals.

IPC Classes  ?

• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
• G06F 7/50 - AddingSubtracting
• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G09C 1/00 - Apparatus or methods whereby a given sequence of signs, e.g. an intelligible text, is transformed into an unintelligible sequence of signs by transposing the signs or groups of signs or by replacing them by others according to a predetermined system
• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems

Abstract

A multiple-layer gas diffusion electrode for sustaining electrochemical reduction of gaseous CO2 and/or CO into multi-carbon products is provided, including a gas diffusion layer comprising a support layer, a microporous layer having pores that are sized to maintain the gaseous CO2 and/or CO, or a combination thereof available for electroreduction, and a catalytic layer comprising a catalyst favoring reduction of the CO2 and/or CO. There are also provided, a method for producing the gas diffusion electrode, a spacer being positionable between an ion exchange membrane and an anode of a membrane electrode assembly, a reactor including a membrane electrode assembly and a support structure, a stack reactor that can include the gas diffusion electrode and the spacer as described herein, a method to diagnose and isolate at least one faulty repeat cell unit in an electrolyzer stack reactor, and a rinsing method for facilitating operation of an electroreduction system.

IPC Classes  ?

• C25B 11/032 - Gas diffusion electrodes
• C25B 1/23 - Carbon monoxide or syngas
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate

Abstract

The present disclosure provides biostable dental resin acrylate-based monomers useful in resin-based restorative materials which exhibit enhanced resistance to breakdown catalyzed by salivary enzymes. These hydrolytically stable monomers possess crosslinkable moieties susceptible to free radical polymerization.

IPC Classes  ?

• C07C 271/00 - Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
• C07C 233/00 - Carboxylic acid amides

Abstract

The present application relates to compounds (e.g. Formulae III, V, VII, IX, and XII) having a negative singlet-triplet gap and a positive oscillator strength. The present application also relates to use of the compounds of the present application in photocatalysis and in OLEDs as emitters and/or dopants. The present application relates to compounds (e.g. Formulae III, V, VII, IX, and XII) having a negative singlet-triplet gap and a positive oscillator strength. The present application also relates to use of the compounds of the present application in photocatalysis and in OLEDs as emitters and/or dopants.

IPC Classes  ?

• H10K 85/60 - Organic compounds having low molecular weight
• C07D 487/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H01S 5/36 - Structure or shape of the active regionMaterials used for the active region comprising organic materials

Abstract

An azide-containing cross-linker and method of preparing the same are provided. Such cross-linker can be used as an intermediate in a scalable production of a cross-linked hemoglobin protein having its beta subunits covalently linked to the azide-containing cross-linker. The present disclosure also pertains to a hemoglobin-based oxygen carrier (HBOC) comprising a pair of azide cross-linked hemoglobin proteins coupled by a copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) and a method for preparing the same. The HBOC may be used in a method for increasing oxygen transport or for use in transfusions or perfusions. An azide-containing cross-linker and method of preparing the same are provided. Such cross-linker can be used as an intermediate in a scalable production of a cross-linked hemoglobin protein having its beta subunits covalently linked to the azide-containing cross-linker. The present disclosure also pertains to a hemoglobin-based oxygen carrier (HBOC) comprising a pair of azide cross-linked hemoglobin proteins coupled by a copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) and a method for preparing the same. The HBOC may be used in a method for increasing oxygen transport or for use in transfusions or perfusions.

IPC Classes  ?

• C07K 14/805 - HaemoglobinsMyoglobins
• A61K 38/00 - Medicinal preparations containing peptides
• C07F 9/09 - Esters of phosphoric acids

Abstract

Aptamers as nucleic acid affinity reagents are gaining traction in analytical applications owing to their high stability, compact size, and amenability to chemical modifications. It is highly desired to generate aptamers with different binding affinities to meet the requirements of various applications. However, systematic evolution of ligands by exponential enrichment (SELEX), the gold standard for aptamer generation, is unable to quantitatively produce aptamers with desired binding affinities and requires multiple rounds of selection to eliminate false positive hits. Here we introduce Pro-SELEX, a new approach for rapid discovery of aptamers with precisely defined binding affinities that combines efficient particle display, high-performance microfluidic sorting and high-content bioinformatics. Using the Pro-SELEX workflow, we were able to investigate the binding performance of individual aptamer candidates under different selective pressure in a single round of selection. Using human myeloperoxidase (MPO) as a target, we demonstrated that aptamers with dissociation constants spanning a twenty-fold range of affinities can be identified within one round of Pro-SELEX. Our selection strategy will have a significant impact on the fields of biosensing and bioseparation by generating aptamers with tailored binding affinities.

IPC Classes  ?

• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (III) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection. The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (III) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection.

IPC Classes  ?

• A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
• A01N 43/54 - 1,3-DiazinesHydrogenated 1,3-diazines
• A01N 43/60 - 1,4-DiazinesHydrogenated 1,4-diazines
• A01P 5/00 - Nematocides
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 33/10 - Anthelmintics

Abstract

This disclosure relates to a method to identify xenobiotics that can debilitate a target organism. In particular, the present disclosure provides methods of heterologously expressing a xenobiotic metabolizing enzyme from the target organism in yeast, libraries of yeast strains heterologously expressing a different xenobiotic metabolizing enzyme and methods of screening libraries with xenobiotics to identify a xenobiotic that debilitates a target organism. The disclosure further relates to a method of treating or preventing a nematode infection comprising administering, to a subject in need thereof, an effective amount of a compound of Formula I, or a solvate thereof, as well as certain novel compounds of Formula I, or a solvate thereof.

IPC Classes  ?

• C12Q 1/18 - Testing for antimicrobial activity of a material
• A01N 43/82 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with three hetero atoms
• A01P 5/00 - Nematocides
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase

Abstract

There is provided a pressure sensor for converting applied pressure to electrical signals, a method for using the pressure sensor, and a method for calibrating the pressure sensor. The pressure sensor including: a non-conductive substrate; conductive material in the non-conductive substrate, the conductive material forming a lattice structure; and a plurality of electrodes connected to the conductive material at respective locations of a boundary of the lattice structure.

IPC Classes  ?

• G01L 1/20 - Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluidsMeasuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress
• G01L 25/00 - Testing or calibrating of apparatus for measuring force, torque, work, mechanical power, or mechanical efficiency

Abstract

Various embodiments for AI-based systems and methods for engineering ionizable lipids for lipid nanoparticle (LNP)-based cargo molecule delivery are disclosed herein. In one example embodiment, the method comprises: designing a plurality of ionizable lipid structures based on a combination of a plurality of lipid headgroups, a plurality of first tailgroups and a plurality of second tailgroups; training a machine learning model based on the plurality of ionizable lipid structures; subsequently, selecting a first subset of ionizable lipid structures from the plurality of ionizable lipid structures and designating the first subset of ionizable lipid structures as experimental ionizable lipid structures; synthesizing, for example using a high throughput synthetic method, each of the experimental ionizable lipid structures; preparing a first set of separate LNPs, each LNP comprising a unique experimental ionizable lipid structure and the cargo molecule; determining a corresponding cargo molecule transfection efficiency value of each of the prepared LNPs in a target cell; further training the machine learning model based on the prepared LNPs and the corresponding cargo molecule transfection efficiency values; and deploying the further trained machine learning model to identify at least one lead ionizable lipid structure.

IPC Classes  ?

• G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
• A61K 9/51 - Nanocapsules
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• G06N 20/00 - Machine learning
• G16C 20/64 - Screening of libraries
• G16C 20/70 - Machine learning, data mining or chemometrics
• G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance

Abstract

2+2+2422 capture operations, such as direct air capture.

IPC Classes  ?

• C25B 3/26 - Reduction of carbon dioxide
• B01D 53/62 - Carbon oxides
• B01J 39/08 - Use of material as cation exchangersTreatment of material for improving the cation exchange properties
• B01J 47/12 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

There is provided a system and method for determining active and reactive currents during asymmetrical low-voltage ride through (LVRT) conditions at an inverter. The method including: receiving an indication of an LVRT condition; and where the largest phase current magnitude does not exceed a phase current limit, determining a maximum active current for associated positive-sequence and negative-sequence reactive currents by determining a largest active current magnitude and outputting the largest active current and associated positive-sequence and negative-sequence reactive currents to the inverter, otherwise: scaling down each of the positive-sequence and negative-sequence reactive currents, or superimposed positive-sequence and negative-sequence reactive currents, uniformly or non-uniformly to determine revised positive-sequence and negative-sequence reactive currents; where the magnitudes of all of the phase currents are below the phase current limit, determining a non-zero positive-sequence revised active current; and outputting the revised active current and the revised positive-sequence and negative-sequence reactive currents to the inverter.

IPC Classes  ?

• H02M 1/32 - Means for protecting converters other than by automatic disconnection
• G01R 19/06 - Measuring real componentMeasuring reactive component
• H02M 1/00 - Details of apparatus for conversion
• H02M 7/5395 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency by pulse-width modulation

Abstract

The proposed system can be utilized in the field of electric and hybrid vehicles, and in particular, provide an improved traction-to-auxiliary converter topology, circuit, and control approach that can be utilized for inverter-based vehicles (e.g., cars, ships, airplanes) that controls charging of different batteries such that an auxiliary vehicle battery (e.g., for headlamps, air conditioning, electrical subsystems) can be charged. A proposed approach is utilized for introducing a controlled phase shift/delay between operation of the inverter(s) for charging the auxiliary vehicle battery.

IPC Classes  ?

• H02J 7/34 - Parallel operation in networks using both storage and other DC sources, e.g. providing buffering
• B60L 50/60 - Electric propulsion with power supplied within the vehicle using propulsion power supplied by batteries or fuel cells using power supplied by batteries
• B60L 53/22 - Constructional details or arrangements of charging converters specially adapted for charging electric vehicles
• B60R 16/033 - Electric or fluid circuits specially adapted for vehicles and not otherwise provided forArrangement of elements of electric or fluid circuits specially adapted for vehicles and not otherwise provided for electric for supply of electrical power to vehicle subsystems characterised by the use of electrical cells or batteries
• H02M 1/00 - Details of apparatus for conversion
• H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

The present disclosure concerns the use of agents to increase the size of a population of normal hematopoietic stem and progenitor cells (HSPCs) outside of the body. The present disclosure also concerns the therapeutic use of a population of normal HSPCs, where the population size has been increased by the use of the agents. The present disclosure also concerns a kit that contains agents that can be use to increase the size of a population of normal HSPCs outside of the body.

IPC Classes  ?

• C12N 5/0789 - Stem cellsMultipotent progenitor cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells

Abstract

Provided is a system and method for sensory testing of a user. The method includes: initializing probability matrices based on knowledge of a sensory field; iteratively performing trials at locations in the sensory field until termination criteria have been met, where each trial is conducted at a particular location in the sensory field by providing a particular intensity of a stimulus to the user, each trial including: receiving a result that includes an indication from the user in response to the stimulus; transforming a set of psychometric functions using the result; updating the probability matrices by multiplying the probability matrices by the set of transformed psychometric functions; and generating updated probability distributions of sensory field estimates for locations in the sensory field using the updated probability matrices; determining statistical measures that describe the updated probability distributions; and outputting the statistical measures as estimates of the sensory field.

IPC Classes  ?

• A61B 3/032 - Devices for presenting test symbols or characters, e.g. test chart projectors

Abstract

Novel chimeric peptides comprise an N-cadherin binding domain for binding N-cadherin, which is expressed on the surface of cells, in particular smooth muscle cells, and a fibronectin- binding domain, which binds surrounding extracellular matrix and a binding site for fibronectin. The chimeric peptides can be loaded on to nanoparticles, suitably degradable polar hydrophobic ionic polyurethane (D-PHI) nanoparticles for delivery, which can be incorporated into coatings for medical devices, including stents and balloons.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• A61K 9/51 - Nanocapsules
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61L 27/28 - Materials for coating prostheses
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 31/08 - Materials for coatings
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/05 - Epstein-Barr virus
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof
• C07K 17/08 - Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer

Abstract

Disclosed herein are methods for making a poptoid using green solvents such as ethyl acetate, DMSO and/or mixtures thereof. Methods using an acylation solvent that is DMSO or EIOAc or mixtures thereof as well as methods using an acylation wash solvent comprising DMSO wherein the DMSO is greater than 30% v/v are described.

IPC Classes  ?

• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents

Abstract

A microfluidics device comprises a cover mounted to an addressing structure. The cover has a working surface on one side, and a plurality of electrodes on its other side. The electrodes may be used for manipulation of fluid droplets on the working surface. The electrodes are connected to a voltage source by way of the addressing structure to selectively apply voltage to individual ones of the plurality of electrodes.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices

Abstract

There is provide herein a compound of Formula (3): There is provide herein a compound of Formula (3): wherein R1, R2, R3, R4, R5, R6, and R7 are each independently H or an organic group.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C07F 5/04 - Esters of boric acids

Abstract

There is provided a light-harvesting heterostructure for a photovoltaic device. The photovoltaic device includes at least an electron-transport layer and a hole-transport layer. The light-harvesting heterostructure includes a 3D perovskite material contacting one of the electron-transport layer and the hole-transport layer. The light-harvesting heterostructure also includes a 2D perovskite capping material extending over at least a portion of the 3D perovskite material and contacting another one of the electron-transport layer and the hole-transport layer. The 2D perovskite capping material includes one or more perovskite layers, each perovskite layer having a corresponding width n, wherein a majority of the corresponding width n is greater or equal to 3. The 2D perovskite capping material also includes a spacer extending between two subsequent perovskite layers.

IPC Classes  ?

• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 30/85 - Layers having high electron mobility, e.g. electron-transporting layers or hole-blocking layers
• H10K 30/86 - Layers having high hole mobility, e.g. hole-transporting layers or electron-blocking layers
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating

Abstract

There is provided an iron-based complex of formula (IA) or (IB) or a solvate thereof (IA) (IB). The iron-based complex can be used for catalyzing a hydrosillation reaction, such as the hydrosilylation of a ketone or an aldehyde. Also provided is a method for preparing a silyl ether from a ketone or an aldehyde comprising the hydrosilylation of the ketone or aldehyde in the presence of the iron-based complex. Another method is provided for the synthesis of an alcohol from a ketone or an aldehyde comprising the hydrosilylation of the ketone or aldehyde in the presence of the iron-based complex to form a silyl ether, and then hydrolyzing the silyl ether to obtain the alcohol. A process for preparing the iron-based complex is further disclosed.

IPC Classes  ?

• B01J 31/22 - Organic complexes
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
• C07F 7/08 - Compounds having one or more C—Si linkages
• C07F 15/02 - Iron compounds

Abstract

The present disclosure relates to compounds of Formula I, element tags comprising soft metals, and methods and kits therefore for performing mass cytometry.

IPC Classes  ?

• C08F 8/42 - Introducing metal atoms or metal-containing groups
• C08F 20/38 - Esters containing sulfur

Abstract

A phased array antenna includes a substrate including an antenna element formed in an upper surface of the substrate. The antenna element is capable of being driven in order to create a propagation pattern. An upper substrate is positioned in a coplanar arrangement a distance above the substrate. The upper substrate includes a lattice of metallic scatterers formed in a plane of the upper substrate. The upper substrate includes a metamaterial including a metasurface with a plurality of unit cells formed therein with the plurality of unit cells arranged in a repeating pattern.

IPC Classes  ?

• H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
• H01Q 3/26 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture

Abstract

There is provided an electrical power converter from an input power source to a load and a method of controlling the power electronics converter. The converter including: a flying capacitor; an inductor electrically connected to the input power source; and a plurality of switches positioned in a circuit with the inductor, the flying capacitor, and the load to control electrical connections between the inductor, the flying capacitor, and the load, the plurality of switches configured to connect the inductor and the flying capacitor to the input power source to fully charge the flying capacitor to a blocking voltage in a charging configuration, and configured to connect the flying capacitor to the load to fully discharge the flying capacitor in a discharging configuration.

IPC Classes  ?

• H02M 1/00 - Details of apparatus for conversion
• H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters

Abstract

An integrated charging topology is introduced for drivetrain solutions operating split-phase machines with variations are proposed both for single phase and multi phase variants. An active power decoupling variant is introduced using a single-input space vector decomposition and the usage of a power ripple phasor. This variant approach enables closed-loop control of the harmonic output power ripple (e.g., second harmonic), compensating for unmeasured effects, such as the interfacing inductance periodic energy storage, and allowing for a near-total reduction in the experimental setting. In operation, the control approach can include controlling the average power transfer between the grid and the battery and/or attenuating a second harmonic power ripple.

IPC Classes  ?

• H02J 7/14 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from dynamo-electric generators driven at varying speed, e.g. on vehicle
• B60L 53/24 - Using the vehicle's propulsion converter for charging

Abstract

A three-phase heterogeneous photocatalyst composition is provided for catalysing dry reforming reactions. The photocatalyst composition is comprised of a photochemically active component, a photothermal component, and a plasmonic material that function synergistically to catalyze dry reforming reactions.

IPC Classes  ?

• B01J 27/185 - PhosphorusCompounds thereof with iron group metals or platinum group metals
• B01J 35/39 - Photocatalytic properties
• B01J 35/45 - Nanoparticles

Abstract

A heterologous transcriptional activator comprising a DNA targeting domain, preferably a catalytically inactive DNA targeting protein such as a CRISPR-Cas protein, and an effector domain comprising at least one transactivation domain described herein or an functional variant thereof. Also provided herein are expression constructs, vectors, and cells encoding or expressing said transcriptional activator, as well as systems and methods for transcriptional activation of a target gene, and compositions, kits and reagents employed in the making and use thereof.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

Methods and compositions for treating or preventing a neurodegenerative disease, such as Alzheimer's Disease, in a subject by administering to a subject a therapeutic amount of a pharmaceutical composition comprising a recombinant SUMO2 analogue.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 47/02 - Inorganic compounds
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 15/09 - Recombinant DNA-technology
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

22 and/or CO under acidic electroreduction conditions, remarkable in that the copper (Cu) is electrodeposited onto a substrate from an electrolyte solution comprising a copper precursor and wherein said electrolyte solution has a pH of at most 3.

IPC Classes  ?

• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/032 - Gas diffusion electrodes
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/065 - Carbon
• C25B 11/069 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of at least one single element and at least one compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of two or more compounds
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C25B 15/00 - Operating or servicing cells
• C25D 3/38 - ElectroplatingBaths therefor from solutions of copper
• C25D 5/54 - Electroplating of non-metallic surfaces

Abstract

The present invention relates to systems and methods for generating protein sequences using machine learning model. The training method including: training an encoder artificial neural network to map amino-acid-level representations into latent variables in a latent space, the amino-acid-level representations generated by a pre-trained protein language model using received input training samples as input; training a decoder artificial neural network to reconstruct protein sequences using the mapped latent variables as input, the decoder artificial neural network and the encoder artificial neural network trained using determination of a loss between the reconstructed protein sequences and the naturally-occurring protein sequences; and outputting the trained encoder artificial neural network and the trained decoder artificial neural network.

IPC Classes  ?

• G16B 40/20 - Supervised data analysis
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

A self-adhesive, conductive hydrogel composition for use as a skin-contacting electrode comprises a hydrogel comprising a crosslinked hydrophilic matrix polymer, a conductive agent, and an adhesive agent. The conductive and adhesive agents may comprise up to about 5% w/w of the composition. The hydrogel may be carboxymethyl cellulose with phytic acid as crosslinker; the conductive agent may be polystyrene sulfonate; and the adhesive agent may comprise tannic acid, polydopamine, or a combination of both. The composition may be prepared from a mixture of a first precursor of the hydrophilic matrix polymer or a salt thereof with water and the adhesive and conductive agents and a second precursor with the crosslinking agent.

IPC Classes  ?

• A61K 50/00 - Electrically conductive preparations for use in therapy or testing in vivo, e.g. conductive adhesives or gels to be used with electrodes for electrocardiography [ECG] or for transcutaneous drug administration
• A61B 5/259 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes using conductive adhesive means, e.g. gels
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C08J 3/075 - Macromolecular gels
• C08L 1/28 - Alkyl ethers
• C08L 25/18 - Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
• C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCompositions of derivatives of such polymers

Abstract

There is provided a system and method for single-photon imaging. The method including: receiving a plurality of asynchronous, or partially asynchronous, single-photon detections and an absolute timestamp associated with each one of the received single-photon detections; performing probing measurements to determine a sum of values of a probing function on the single-photon detection values at each of the absolute timestamps; reconstructing a continuous- time flux function from the probing measurements; and outputting the reconstructed continuous- time flux function or an integral thereof.

IPC Classes  ?

• H04N 23/82 - Camera processing pipelinesComponents thereof for controlling camera response irrespective of the scene brightness, e.g. gamma correction

Abstract

Amphiphilic oligomers are provided that yield phase-separated gels suitable for sustained release drug delivery. The amphiphilic backbone includes a hydrophilic domain and a degradable hydrophobic domain, which are linked with an isocyanate group, while the terminal domains on the oligomer are functionalized with catechol adhesive groups capable of cross-linking.

IPC Classes  ?

• C08G 18/42 - Polycondensates having carboxylic or carbonic ester groups in the main chain
• C08G 18/24 - Catalysts containing metal compounds of tin
• C08G 18/40 - High-molecular-weight compounds
• C08G 18/48 - Polyethers
• C08G 18/77 - Polyisocyanates or polyisothiocyanates having hetero atoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur

Abstract

The present application includes dendrons of Formula I, compositions comprising these dendrons and uses thereof, in particular for the delivery of agents such as nucleic acids and drugs to cells and subjects. The present application includes dendrons of Formula I, compositions comprising these dendrons and uses thereof, in particular for the delivery of agents such as nucleic acids and drugs to cells and subjects. The present application includes dendrons of Formula I, compositions comprising these dendrons and uses thereof, in particular for the delivery of agents such as nucleic acids and drugs to cells and subjects. wherein each Repeating Group is the same or different.

IPC Classes  ?

• C08G 83/00 - Macromolecular compounds not provided for in groups
• A61K 9/51 - Nanocapsules

Abstract

A computer-implemented method and system for implementing a n-fold fermionic excitation generator using linear combination of directly differentiable operators on a quantum computer. Computer-readable data is generated and stored which when executed on the quantum computer, causes a quantum circuit of the quantum computer to execute repeatedly to perform a sequence of operations that implements the unitary (I) generated by a fermionic n-fold excitation operator G. The Gradient with respect to the angle Θ of arbitrary expectation values involving the unitary operation can, in the general case, be evaluated by four expectation values obtained from replacing the corresponding unitary with fermionic shift operations (II). Fermionic shift operations can be constructed through the original unitary and unitary operations generated by the nullspace projector P0 of the fermionic excitation generator. Other operators and generators are disclosed.

IPC Classes  ?

• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms
• G06F 17/14 - Fourier, Walsh or analogous domain transformations
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

There is provided a method and image sensor for flux-to-digital conversion for a pixel of an image sensor. The method including: receiving light for a pixel in the image sensor while the pixel is being exposed to the light for an exposure period, the pixel provides an output that is a function of the light received; performing line fitting on transients of the pixel output, the transients determined using a periodic reference voltage; and outputting the line fitting value as the digital representative of the received light flux. The image sensor including a first port for receiving an exposure code that configures an exposure of the pixels in the array; and a second port for readout of the digital representative value, where line fitting is performed on transients of the readout, the transients determined using periodic reference voltage, and where the line fitting value is the digital representative value.

IPC Classes  ?

• H04N 25/53 - Control of the integration time
• H04N 25/77 - Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components

Abstract

An electroreduction system for converting carbon oxides selected from CO, CO2 or any mixture thereof into multicarbon (C2+) products. the system comprising a cathodic compartment having a reactant inlet and comprising a cathode, the cathode comprising a catalyst layer that is contactable with a catholyte solution; an anodic compartment having a product outlet to release the C2+ products, the anodic compartment comprising an anode and being configured to accommodate a flowing anolyte solution; and a bipolar membrane being positioned between the cathodic compartment and the anodic compartment, the bipolar membrane comprising an interfacial layer defined between a cation-exchange layer and a anion-exchange layer, wherein the cathodic compartment is configured to accommodate a stationary catholyte layer between the catalyst layer of the cathode and the CEL, the stationary catholyte layer comprising the catholyte solution.

IPC Classes  ?

• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 3/26 - Reduction of carbon dioxide
• C25B 9/21 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms two or more diaphragms
• C25B 11/032 - Gas diffusion electrodes
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 15/027 - Temperature
• C25B 15/031 - Concentration pH

Abstract

Provided are antibodies or fragments thereof having binding specificity to anti-IL-18 receptor alpha or beta. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory and autoimmune diseases are also provided.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Disclosed are optical devices suitable as security devices for document authentication, which comprise at least one two-dimensional array of elongate laser-modified tracks extending within a document substrate that have a distinct optical refractive index compared to the unmodified substrate, which can exhibit excellent diffractive effects. Also disclosed are the use of such devices for document authentication and methods for their production.

IPC Classes  ?

• B42D 25/435 - Marking by removal of material using electromagnetic radiation, e.g. laser
• B23K 26/354 - Working by laser beam, e.g. welding, cutting or boring for surface treatment by melting
• B23K 26/359 - Working by laser beam, e.g. welding, cutting or boring for surface treatment by providing a line or line pattern, e.g. a dotted break initiation line
• B41M 3/14 - Security printing
• B42D 25/29 - Securities Bank notes
• B42D 25/328 - Diffraction gratingsHolograms
• B42D 25/41 - Marking using electromagnetic radiation

Abstract

2222 into CO, wherein the first metal-based catalyst is atomically dispersed on the support; and a second catalyst layer comprising a second metal-based catalyst that is configured to sustain C-C coupling mechanisms to yield multi-carbon products from CO; wherein the first catalyst layer is positioned above the second catalyst layer to generate CO between the first catalyst layer and the second catalyst layer.

IPC Classes  ?

• C25B 3/20 - Processes
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/053 - Electrodes comprising one or more electrocatalytic coatings on a substrate characterised by multilayer electrocatalytic coatings
• C25B 11/095 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one of the compounds being organic
• C25B 1/23 - Carbon monoxide or syngas

Abstract

The present disclosure relates to the manufacturing and use of co-doped multi-metallic electrocatalysts for electroreduction of CO or CO2 to produce n-propanol. The co-doped multi-metallic electrocatalyst includes Cu as well as Ag and a secondary dopant, such as Ruthenium (Ru), Rhodium (Rh), Iridium (Ir), Palladium (Pd), Gold (Au) or Platinum (Pt). The co-doped multi-metallic electrocatalyst can be manufactured using a two-stage method where Cu nanoparticles are first doped with Ru and then doped with Ag. The co-doped multi-metallic electrocatalysts facilitate adsorption of CO, C1-C1 coupling, C1-C2 coupling and certain kinetics for the production of propanol by electroreduction with good selectivity at high current densities.

IPC Classes  ?

• C25B 11/097 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds comprising two or more noble metals or noble metal alloys
• C07C 29/48 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
• C25B 3/07 - Oxygen containing compounds
• C25B 3/25 - Reduction
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/032 - Gas diffusion electrodes

Abstract

The present application includes dendrons of Formula I, compositions comprising these dendrons and uses thereof, in particular for the delivery of agents such as nucleic acids and drugs to cells and subjects. The present application includes dendrons of Formula I, compositions comprising these dendrons and uses thereof, in particular for the delivery of agents such as nucleic acids and drugs to cells and subjects. The present application includes dendrons of Formula I, compositions comprising these dendrons and uses thereof, in particular for the delivery of agents such as nucleic acids and drugs to cells and subjects. wherein each Repeating Group is the same or different.

IPC Classes  ?

• C08G 83/00 - Macromolecular compounds not provided for in groups
• A61K 9/51 - Nanocapsules

Abstract

A magnetic torsion spring for a magnetically actuated mechanism, the spring having first and second links of the mechanism rotatably connected at a joint of the mechanism, the first link provided with a first magnet spaced from the joint and the second link provided with a second magnet spaced from the joint generating a spring effect, the spring defined by a torque curve with respect to spring deflection, the torque curve defined by spring type, dimensionless characteristic length ratio of the spring, and an amplitude constant, and the length ratio has a value between 0 and 1.

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

Methods and devices for analyzing and updating intermediate representations containing pointers includes compiling one or more source files into intermediate representations (IRs) having pointers, analyzing the IRs, producing transformed IRs comprising updated pointers, and producing object code from the transformed IRs. The device may include one or more non-transitory computer-readable storage devices having computer-executable instructions, when executed, cause a processing structure to perform the actions described relating to pointers. The analysis and updating of pointers may relate to types of bounds to enhance security of the systems in question by preventing erroneous references to memory space by pointers.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

Cryptographic processor chips, systems and associated methods are disclosed. In one embodiment, a cryptographic processor is disclosed. The cryptographic processor includes a first cryptographic processing module to perform a first logic operation. The first cryptographic processing module includes first input circuitry to receive ciphertext input symbols. A first pipeline stage performs a first operation on the ciphertext input symbols and generates a first stage output. On-chip memory temporarily stores the first stage output and feeds the first stage output to a second pipeline stage in a pipelined manner. The second pipeline stage is configured to perform a second operation on the first stage output in a pipelined manner with respect to the first pipeline stage.

IPC Classes  ?

• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems

Abstract

The present disclosure provides a method for generating progenitor T cells from stem and/or progenitor cells comprising exposing the stem and/or progenitor cells to Notch ligand Delta-like-4 (DL4) and vascular adhesion molecule 1 (VCAM-1) under conditions suitable to generate progenitor T cells. The method provided is suitable for in vitro and in vivo pro-T cell generation. In vitro, the pro-T cells are generated under serum-free conditions. Cells produced using the method are provided as well as methods of using same.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• A61P 35/00 - Antineoplastic agents
• C12N 5/074 - Adult stem cells
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 5/0789 - Stem cellsMultipotent progenitor cells

Abstract

Methods and modules for accelerating inference computations in transformer models using edge devices includes partitioning inputs for each layer and synchronizing between transformer layers. A method includes receiving a transformer input, partitioning the transformer input into two or more first-stage divisions, processing each first-stage division into a processed first-stage division, and combining the processed first-stage divisions into a first output. A module includes a computing device for partitioning a transformer input into two or more divisions, transmitting each of the divisions, and receiving processed divisions, as well as two or more transformer processing units, each for receiving a division from the computing device, processing the division into a processed division, and sending the processed division to the computing device.

IPC Classes  ?

• G06N 5/04 - Inference or reasoning models

Abstract

A fully dilutable in aqueous phase self-microemulsifying system for the delivery of one or more polar oil active compounds having a positive characteristic curvature (Cc), comprising: a lecithin compound; a hydrophilic linker or a combination two or more hydrophilic linkers, the hydrophilic linker or the combination of two or more hydrophilic linkers having one having one hydrocarbon group with 6 to 10 carbon atoms, and the hydrophilic linker or the combination of two or more HLs having a Cc of about −5 or more negative than about −5; and a carrier oil.

IPC Classes  ?

• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/107 - Emulsions
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/05 - Phenols

Abstract

The present application provides compositions and methods of use for inhibiting DUPD1 activity or by reducing or eliminating expression of DUPD1 in order to treat and/or prevent inflammatory bowel disease, including Crohn's disease and ulcerative colitis, colitis- associated colon cancer, or a metabolic disorder, such as obesity or an obesity-associated metabolic disorder, or for glucose regulation in a subject. The present application further relates to the identification of compounds that are useful in treating and/or preventing inflammatory bowel disease, colitis-associated colon cancer, or a metabolic disorder, or for glucose regulation.

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/18 - Sulfonamides
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 35/00 - Antineoplastic agents
• C07C 311/09 - Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
• C07C 323/22 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
• C07D 215/38 - Nitrogen atoms
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

There is provided systems and methods for generating formulations with improved performance and lower resource consumption. The population of formulations may be created by a Differential Evolution (DE) process. In each successive generation, lower performing formulations may be replaced with new formulations predicted to have better performance by a modeling pipeline. The modeling pipeline may perform a search for ML architectures and hyperparameter optimization for a suitable ML architecture, and then train one or more machine learning models to minimize error (otherwise maximizing the resulting score for a formulation). The machine learning models may be an ensemble of Random Forest models. These new formulations may form part of the next generation in the DE process. This modified version of the Differential Evolution process using machine learning techniques may result in populations of formulations which are superior in performance, and/or require fewer iterations of generations to achieve formulations which meet performance objectives.

IPC Classes  ?

• G16C 20/70 - Machine learning, data mining or chemometrics
• G06N 3/02 - Neural networks
• G06N 20/20 - Ensemble learning
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

The invention describes methods and reagents useful for sequencing polypeptide molecules. The method comprises affixing a polypeptide to a substrate and contacting the polypeptide with a plurality of probes that selectively bind to a terminal amino acid or a terminal amino acid derivative. Probes bound to the polypeptide molecule are then identified before cleaving the terminal amino acid or terminal amino acid derivative of the polypeptide. Also provided are probe compositions comprising (a) a ClpS variant comprising at least 80% sequence identity to SEQ ID NO: 1, wherein the ClpS variant binds to an N-terminal amino acid or a N-terminal amino acid derivative with a different selectivity than a wild-type ClpS; and (b) a detectable label.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07K 14/245 - Escherichia (G)
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

Systems and methods for vegetation detection from aerial photogrammetric multispectral data. The method includes: detecting apexes in a height model using Local Maxima (LM) detection; detecting vegetation as detected apexes; performing orthorectification to derive an orthomosaic; generating a fractional map of a vegetation class by applying a Fuzzy classifier on the orthomosaic using the detected vegetation to define the class; generating a binary ridge map using the height model to identify ridges; combining the binary ridge map and the fractional map of the vegetation class to generate a ridge integrated fractional map; performing delineation of individual vegetation on the ridge integrated fractional map on a vegetation class using an active contour algorithm; and outputting the delineated vegetation.

IPC Classes  ?

• G06V 20/10 - Terrestrial scenes
• G06T 5/70 - DenoisingSmoothing
• G06V 10/34 - Smoothing or thinning of the patternMorphological operationsSkeletonisation

Abstract

The present invention relates to compositions, methods and uses of Teneurin C-Terminal Associated Peptide (TCAP) as an antagonist of corticotropin-releasing factor (CRF). In some other embodiments the invention relates to methods and uses of TCAP to regulate cytosolic and mitochondrial calcium levels, such as mediate, control elevated cytosolic calcium levels or low mitochondrial calcium levels or efflux of calcium from the mitochnodria, such as that may be the result of CRF activity. In other aspects the invention provides a method of treating CRF- dependent or mediated conditions or symptoms by using or administering TCAP.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/00 - Drugs for disorders of the nervous system
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

Disclosed are optical devices suitable as security devices for document authentication, which comprise at least one array of patterns such as laser-fabricated patterns, or other structures, optionally formed for example from elongate laser-modified tracks extending within a document substrate. The patterns are combined with at least one array of microlenses to cause certain optical effects. Also disclosed are the use of such devices for document authentication, and methods for their production.

IPC Classes  ?

• G02B 3/00 - Simple or compound lenses
• B42D 25/328 - Diffraction gratingsHolograms
• B42D 25/351 - Translucent or partly translucent parts, e.g. windows
• B42D 25/41 - Marking using electromagnetic radiation
• G02B 5/18 - Diffracting gratings

Abstract

The disclosure provides antibodies that bind human ITGAv/B1 and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-ITGAv/B1 antibody.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 35/00 - Antineoplastic agents

Abstract

A method to obtain a cache miss ratio curve where a memory blocks of a cache have variable block sizes. By stacking sets of counters, each set being for a different block size, a stack distance for variable block sizes can be obtained and used to determine a miss ratio curve. Such curve can then be used to select a cache size that is appropriate for an application without requiring excessive memory. Methods can be used for batches of request, can apply limits to block sizes, and rounding for intermediary block sizes, they can be used with pruning, and their space complexity can be held constant.

IPC Classes  ?

• G06F 12/0815 - Cache consistency protocols

Abstract

Methods and systems for mRNA analysis and quantification of mRNA expression in cells are provided. An example method includes introducing a first capture probe and a second capture probe into the cells, the first capture probe and the second capture probe each configured to be complementary to a respective section of target mRNA within the cells, wherein binding of the first and second capture probes to the respective sections of the target mRNA results in tagging of the cells and causes the first and second capture probes to form clusters with each other. The first capture probe and the second capture probe are each bound to magnetic nanoparticles (MNPs) that, when trapped within the tagged cells, cause the tagged cells to be susceptible to magnetic forces. The method and system further include introducing the cells into a device configured to magnetically capture tagged cells.

IPC Classes  ?

• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Some embodiments of the present disclosure provide a deep-learning-based framework for designing components of a downlink precoding system. The components of such a system include downlink training pilots and channel estimation based on receipt of the downlink training pilots. Another component involves channel measurement and feedback strategy at the user equipment. The components include a precoding scheme designed at the base station based on the feedback from the user equipment.

IPC Classes  ?

• H04W 72/21 - Control channels or signalling for resource management in the uplink direction of a wireless link, i.e. towards the network
• G06N 3/04 - Architecture, e.g. interconnection topology
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04L 5/00 - Arrangements affording multiple use of the transmission path
• H04W 76/27 - Transitions between radio resource control [RRC] states