Center for Intelligent Research in Crystal Engineering, S.L.

Spain

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2020 3
Before 2020 3
IPC Class
C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups 4
C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane 4
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol 3
C07C 39/08 - Dihydroxy benzenesAlkylated derivatives thereof 3
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids 2
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NICE Class
01 - Chemical and biological materials for industrial, scientific and agricultural use 5
05 - Pharmaceutical, veterinary and sanitary products 2
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations 1
Status
Pending 5
Registered / In Force 13

1.

PTEROYOUTH

      
Application Number 018926990
Status Registered
Filing Date 2023-09-19
Registration Date 2024-01-18
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Chemical substances and Biochemical substances and natural elements for use in the following fields: manufacture of the following goods: Pharmaceuticals, Veterinary health products, Food stuff, Dietetic products, Cosmetic products, cleaning products and Products for personal care; Chemical compositions and materials for use in cosmetics; Chemical compositions and materials for use in the manufacture of cosmetics; Active chemical ingredients for use in the manufacture of pharmaceuticals; Chemical substances for use in the production of drugs; Chemical and organic compositions for use in the manufacture of food and beverages; Chemical substances, chemical materials and chemical preparations, and natural elements; Chemicals for use as ingredients in the course of manufacture.

2.

PTEROVITA

      
Application Number 1740599
Status Registered
Filing Date 2023-06-12
Registration Date 2023-06-12
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Chemical compositions and materials for scientific use; chemical materials and compositions for use in cosmetics; active chemical ingredients for use in the manufacture of pharmaceutical substances; chemical substances for use in drug production; chemical substances, chemical materials and chemical preparations, and natural elements; chemical active ingredients; active chemical ingredients; chemical products for use as ingredients during manufacturing; chemical substances for use as food ingredients; chemical compositions and materials for use in the manufacture of cosmetics; chemical and organic compounds for use in the manufacture of food and beverages; chemical and biochemical substances and natural elements for use in the manufacture of pharmaceutical, veterinary, food, dietetic, cosmetic and personal care products.

3.

PTEROVITA

      
Serial Number 79374390
Status Registered
Filing Date 2023-06-12
Registration Date 2024-12-03
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Chemical compositions and preparations for scientific use; chemical preparations and compositions for use in the manufacture of cosmetics; active chemical ingredients for use in the manufacture of pharmaceutical substances; chemical substances for use in drug production; chemical active ingredients, namely cocrystals for use in the manufacture of cosmetics, pharmaceuticals, nutritional supplements, dietetic foods and veterinary preparations; active chemical ingredients for use in the manufacture of cosmetics, pharmaceuticals, nutritional supplements, dietetic foods and veterinary preparations; chemical preparations for use as ingredients during manufacturing of cosmetics, pharmaceuticals, nutritional supplements, dietic foods and veterinary preparations; chemical additives for use in the manufacture of food; chemical compositions and preparations for use in the manufacture of cosmetics; chemical and organic chemical compounds for use in the manufacture of food and beverages; chemical and biochemical substances and natural elements in the nature of cocrystal preparations, all for use in the manufacture of pharmaceutical preparations, veterinary preparations, food, dietetic preparations, cosmetics and personal care products

4.

COCRYSTALS OF PTEROSTILBENE AND COMPOSITIONS COMPRISING THEM

      
Application Number 17786510
Status Pending
Filing Date 2020-12-18
First Publication Date 2023-02-16
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande López, Dafne
  • Prohens López, Rafel
  • Barbas Cañero, Rafael

Abstract

The present disclosure relates to a cocrystal of pterostilbene and a coformer capable to form hydrogen bond interactions, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The present disclosure also relates to a composition comprising the cocrystal.

IPC Classes  ?

  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • C07D 213/55 - AcidsEsters

5.

COCRYSTALS OF STEROID AND SECOSTEROID COMPOUNDS AND COMPOSITIONS COMPRISING THEM

      
Application Number 17779512
Status Pending
Filing Date 2020-11-24
First Publication Date 2023-01-05
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande López, Dafne
  • Prohens López, Rafel
  • Barbas Cañero, Rafael

Abstract

It is provided a cocrystal of a compound of formula (I) or of a compound formula (II) wherein X and Y are independently selected from —CH2— and —C(CH2)—, provided that al least one of X or Y is —CH2—; R1 is —CHCH3—Zm—Wn—(CH2)o-Tp-S, wherein Z is O, and m is 0 or 1; W is R4CH CHR5, wherein either R4 and R5 are H and the dashed line indicates that there is a single bond, or R4 and R5 together are forming a bond and the dashed line indicates that there is a double bond, and n is 0 or 1; o is 0, 1 or 3; T is selected from the group consisting of —CHR6—, —C(O), wherein R6 is —OH or —CH3, and p is 0 or 1; S is selected from the group consisting of H, (C1-C3) alkyl optionally substituted by —OH, (C1-C3) haloalkyl optionally substituted by —OH, cyclopropyl, or; and R2 is —H or —OH; R3 is H or CH3; and the dashed line in formula (II) indicates a single or a double bond; and a hydrogen bond donor coformer which is a phenolic compound. It is also provided a composition comprising the cocrystal and a personal care product comprising the composition. It is provided a cocrystal of a compound of formula (I) or of a compound formula (II) wherein X and Y are independently selected from —CH2— and —C(CH2)—, provided that al least one of X or Y is —CH2—; R1 is —CHCH3—Zm—Wn—(CH2)o-Tp-S, wherein Z is O, and m is 0 or 1; W is R4CH CHR5, wherein either R4 and R5 are H and the dashed line indicates that there is a single bond, or R4 and R5 together are forming a bond and the dashed line indicates that there is a double bond, and n is 0 or 1; o is 0, 1 or 3; T is selected from the group consisting of —CHR6—, —C(O), wherein R6 is —OH or —CH3, and p is 0 or 1; S is selected from the group consisting of H, (C1-C3) alkyl optionally substituted by —OH, (C1-C3) haloalkyl optionally substituted by —OH, cyclopropyl, or; and R2 is —H or —OH; R3 is H or CH3; and the dashed line in formula (II) indicates a single or a double bond; and a hydrogen bond donor coformer which is a phenolic compound. It is also provided a composition comprising the cocrystal and a personal care product comprising the composition.

IPC Classes  ?

  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
  • A23L 33/155 - Vitamins A or D
  • A23K 20/174 - Vitamins
  • A23K 50/40 - Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs

6.

PTEROVITA

      
Application Number 018807884
Status Registered
Filing Date 2022-12-13
Registration Date 2023-05-03
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
  • 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Chemical compositions and materials for use in science; Chemical compositions and materials for use in cosmetics; Active chemical ingredients for use in the manufacture of pharmaceuticals; Chemical substances for use in the production of drugs; Chemical substances, chemical materials and chemical preparations, and natural elements; Active chemical ingredients; Active chemical ingredients; Chemicals for use as ingredients in the course of manufacture; Chemical substances for use as food ingredients; Chemical compositions and materials for use in the manufacture of cosmetics; Chemical and organic compositions for use in the manufacture of food and beverages; Chemical substances and Biochemical substances and natural elements for use in the following fields: Manufacture of pharmaceuticals, veterinary, food, dietetic preparations, cosmetics and for personal care. Cosmetics and cosmetic preparations; Skin care preparations, not for medical purposes; Lotions, milks and creams for the body (non-medicated); Skin care creams, other than for medical use; Anti-aging skincare preparations; Anti-aging moisturizers; Anti-aging creams; Anti-aging serum for cosmetic use; Hair preparations and treatments; Cosmetic preparations for the hair and scalp, Not for medical purposes; Moisturizers; Soaps for personal use; Sun creams; Cosmetics for protecting the skin from sunburn; Compounds for skin care after exposure to the suns rays; Sun bronzers. Pharmaceuticals and natural remedies; Sanitary preparations for medical purposes; Skin care preparations for medical use; Medicated creams; Pharmacological preparations for skin care; Pharmaceutical preparations for hair care; Dietary supplements and dietetic preparations; Mineral dietary supplements; Dietary supplements for animals; Nutritional supplements; Dietary and nutritional supplements; Vitamin and mineral preparations; Dietetic food preparations adapted for medical use; Nutraceutical preparations for therapeutic or medical purposes; Veterinary preparations and substances; Medicated food supplements; Food supplements for non-medical purposes; Nutritional supplements; Dietetic substances adapted for medical use; Pharmaceutical preparations for treating sunburn; Medicated sunscreen preparations.

7.

CIRCE SCIENTIFIC

      
Application Number 018790842
Status Registered
Filing Date 2022-11-07
Registration Date 2023-03-31
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Chemical compositions and materials for use in science; Chemical compositions and materials for use in cosmetics; Active chemical ingredients for use in the manufacture of pharmaceuticals; Chemical substances for use in the production of drugs; Chemical substances, chemical materials and chemical preparations, and natural elements; Active chemical ingredients; Active chemical ingredients; Chemicals for use as ingredients in the course of manufacture; Chemical substances for use as food ingredients; Chemical compositions and materials for use in the manufacture of cosmetics; Chemical and organic compositions for use in the manufacture of food and beverages; Chemical substances and Biochemical substances and natural elements for use in the following fields: Manufacture of pharmaceuticals, veterinary, food, dietetic preparations, cosmetics and for personal care. Mineral dietary supplements; Dietary supplements for animals; Nutritional supplements; Dietary and nutritional supplements; Vitamin and mineral preparations; Dietetic food preparations adapted for medical use; Nutraceutical preparations for therapeutic or medical purposes; Veterinary preparations and substances; Medicated food supplements; Food supplements for non-medical purposes; Nutritional supplements; Dietetic substances adapted for medical use.

8.

Cocrystals of ubiquinone and compositions comprising them

      
Application Number 17265327
Grant Number 11952334
Status In Force
Filing Date 2019-08-02
First Publication Date 2021-07-29
Grant Date 2024-04-09
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande Lopez, Dafne
  • Prohens López, Rafel
  • Barbas Cañero, Rafael

Abstract

The present invention relates to a cocrystal of ubiquinone and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.

IPC Classes  ?

  • C07C 50/28 - Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
  • A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
  • A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
  • A61K 9/14 - Particulate form, e.g. powders

9.

COCRYSTALS OF PTEROSTILBENE AND COMPOSITIONS COMPRISING THEM

      
Document Number 03164093
Status Pending
Filing Date 2020-12-18
Open to Public Date 2021-06-24
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande Lopez, Dafne
  • Prohens Lopez, Rafel
  • Barbas Canero, Rafael

Abstract

The present disclosure relates to a cocrystal of pterostilbene and a coformer capable to form hydrogen bond interactions, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The present disclosure also relates to a composition comprising the cocrystal.

IPC Classes  ?

  • A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
  • A61K 31/132 - Amines, e.g. amantadine having two or more amino groups, e.g. spermidine, putrescine
  • A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
  • A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K 31/404 - Indoles, e.g. pindolol
  • A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
  • A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
  • A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
  • A61K 31/4965 - Non-condensed pyrazines
  • A61K 31/4995 - Pyrazines or piperazines forming part of bridged ring systems
  • A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
  • A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
  • A61P 9/00 - Drugs for disorders of the cardiovascular system
  • A61P 19/00 - Drugs for skeletal disorders
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 35/00 - Antineoplastic agents
  • A61P 37/00 - Drugs for immunological or allergic disorders
  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • C07C 65/05 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
  • C07C 211/10 - Diaminoethanes
  • C07C 229/26 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
  • C07C 275/00 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
  • C07C 275/02 - SaltsComplexesAddition compounds
  • C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
  • C07D 213/79 - AcidsEsters
  • C07D 239/557 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
  • C07D 241/12 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
  • C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
  • C07D 295/03 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
  • C07D 471/04 - Ortho-condensed systems
  • C07D 473/08 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
  • C07D 487/08 - Bridged systems

10.

COCRYSTALS OF PTEROSTILBENE AND COMPOSITIONS COMPRISING THEM

      
Application Number EP2020087017
Publication Number 2021/123162
Status In Force
Filing Date 2020-12-18
Publication Date 2021-06-24
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande López, Dafne
  • Prohens López, Rafel
  • Barbas Cañero, Rafael

Abstract

The present disclosure relates to a cocrystal of pterostilbene and a coformer capable to form hydrogen bond interactions, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The present disclosure also relates to a composition comprising the cocrystal.

IPC Classes  ?

  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • A61P 3/02 - Nutrients, e.g. vitamins, minerals
  • C07C 211/10 - Diaminoethanes
  • C07D 213/79 - AcidsEsters
  • C07D 241/04 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
  • C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
  • C07D 295/03 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
  • C07D 487/04 - Ortho-condensed systems
  • C07D 487/10 - Spiro-condensed systems
  • A61K 31/085 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon

11.

COCRYSTALS OF STEROID AND SECOSTEROID COMPOUNDS AND COMPOSITIONS COMPRISING THEM

      
Application Number EP2020083254
Publication Number 2021/105147
Status In Force
Filing Date 2020-11-24
Publication Date 2021-06-03
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande López, Dafne
  • Prohens López, Rafel
  • Barbas Cañero, Rafael

Abstract

2222-; R13mn2opp-S, wherein Z is O, and m is 0 or 1; W is R4CH CHR5, wherein either R4and R5are H and the dashed line indicates that there is a single bond, or R4and R5together are forming a bond and the dashed line indicates that there is a double bond, and n is 0 or 1; o is 0, 1 or 3; T is selected from the group consisting of -CHR6-, -C(O), wherein R6313133) haloalkyl optionally substituted by -OH, cyclopropyl, or; and R2is -H or -OH; R333; and the dashed line in formula (II) indicates a single or a double bond; and a hydrogen bond donor coformer which is a phenolic compound. It is also provided a composition comprising the cocrystal and a personal care product comprising the composicion.

IPC Classes  ?

  • C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
  • C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
  • C07C 39/08 - Dihydroxy benzenesAlkylated derivatives thereof
  • A61K 31/592 - 9,10-Secoergostane derivatives, e.g. ergocalciferol, vitamin D2
  • A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
  • A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
  • A61P 3/02 - Nutrients, e.g. vitamins, minerals
  • A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
  • A61P 35/00 - Antineoplastic agents
  • A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

12.

COCRYSTALS OF STEROID AND SECOSTEROID COMPOUNDS AND COMPOSITIONS COMPRISING THEM

      
Document Number 03161781
Status Pending
Filing Date 2020-11-24
Open to Public Date 2021-06-03
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande Lopez, Dafne
  • Prohens Lopez, Rafel
  • Barbas Canero, Rafael

Abstract

It is provided a cocrystal of a compound of formula (I) or of a compound formula (II) wherein X and Y are independently selected from -CH2- and -C(CH2)-, provided that al least one of X or Y is -CH2-; R1 is -CHCH3-Zm-Wn-(CH2)o-Tp-S, wherein Z is O, and m is 0 or 1; W is R4CH CHR5, wherein either R4 and R5 are H and the dashed line indicates that there is a single bond, or R4 and R5 together are forming a bond and the dashed line indicates that there is a double bond, and n is 0 or 1; o is 0, 1 or 3; T is selected from the group consisting of -CHR6-, -C(O), wherein R6 is -OH or -CH3, and p is 0 or 1; S is selected from the group consisting of H, (C1-C3) alkyl optionally substituted by -OH, (C1-C3) haloalkyl optionally substituted by -OH, cyclopropyl, or; and R2 is -H or -OH; R3 is H or CH3; and the dashed line in formula (II) indicates a single or a double bond; and a hydrogen bond donor coformer which is a phenolic compound. It is also provided a composition comprising the cocrystal and a personal care product comprising the composicion.

IPC Classes  ?

  • A61K 8/63 - SteroidsDerivatives thereof
  • A61K 8/67 - Vitamins
  • A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
  • A61K 31/59 - Compounds containing 9,10-seco-cyclopenta[a]hydro- phenanthrene ring systems
  • C07C 39/08 - Dihydroxy benzenesAlkylated derivatives thereof
  • C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
  • C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

13.

Cocrystals of ubiquinol and compositions comprising them

      
Application Number 16969869
Grant Number 11731927
Status In Force
Filing Date 2019-02-22
First Publication Date 2020-12-10
Grant Date 2023-08-22
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Prohens López, Rafel
  • Barbas Cañero, Rafael
  • Bofill Herrera, Lidia
  • De Sande López, Dafne

Abstract

The present invention relates to a cocrystal of ubiquinol and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.

IPC Classes  ?

  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • C07C 65/05 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

14.

Crystalline forms of beta-sitosterol

      
Application Number 16624842
Grant Number 11591363
Status In Force
Filing Date 2018-06-22
First Publication Date 2020-07-02
Grant Date 2023-02-28
Owner
  • CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
  • ALIMENTOMICA, S.L. (Spain)
Inventor
  • Prohens López, Rafel
  • Barbas Cañero, Rafael
  • Portell Bueso, Anna
  • Palou March, Mariona
  • Serra Vich, Francisca
  • Palou March, Andreu

Abstract

The present invention relates to a cocrystal of beta-sitosterol or a pharmaceutically acceptable ester thereof or an edible acceptable ester thereof and an organic carboxylic acid coformer, an hydrate crystal form of beta-sitosterol having 1.25 molecules of water per molecule of beta-sitosterol and a combination that comprises a cocrystal of beta-sitosterol and an organic carboxylic acid; and the hydrate crystal form of beta-sitosterol having 1.25 molecules of water per molecule of beta-sitosterol. It also relates to processes for their preparation, and compositions containing them, as well as their use as a medicament or dietary supplement or functional food, and in particular in the prophylaxis and/or treatment of a disease or conditions that involves an alteration of lipid metabolism, circulating levels of lipids in the blood and/or lipid composition in tissues and organs.

IPC Classes  ?

  • A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
  • C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

15.

COCRYSTALS OF UBIQUINONE AND COMPOSITIONS COMPRISING THEM

      
Application Number EP2019070856
Publication Number 2020/025781
Status In Force
Filing Date 2019-08-02
Publication Date 2020-02-06
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Bofill Herrera, Lidia
  • De Sande Lopez, Dafne
  • Prohens López, Rafel
  • Barbas Cañero, Rafael

Abstract

The present invention relates to a cocrystal of ubiquinone and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.

IPC Classes  ?

  • C07C 50/28 - Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
  • C07C 39/10 - Polyhydroxy benzenesAlkylated derivatives thereof
  • C07C 39/08 - Dihydroxy benzenesAlkylated derivatives thereof
  • A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
  • A61P 9/00 - Drugs for disorders of the cardiovascular system

16.

COCRYSTALS OF UBIQUINOL AND COMPOSITIONS COMPRISING THEM

      
Application Number EP2019054420
Publication Number 2019/162429
Status In Force
Filing Date 2019-02-22
Publication Date 2019-08-29
Owner CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
Inventor
  • Prohens López, Rafel
  • Barbas Cañero, Rafael
  • Bofill Herrera, Lidia
  • De Sande López, Dafne

Abstract

The present invention relates to a cocrystal of ubiquinol and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.

IPC Classes  ?

  • C07C 43/205 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
  • C07C 41/58 - SeparationPurificationStabilisationUse of additives

17.

CRYSTALLINE FORMS OF BETA-SITOSTEROL

      
Document Number 03067658
Status Pending
Filing Date 2018-06-22
Open to Public Date 2018-12-27
Owner
  • CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
  • ALIMENTOMICA, S.L. (Spain)
Inventor
  • Prohens Lopez, Rafel
  • Barbas Canero, Rafael
  • Portell Bueso, Anna
  • Palou March, Mariona
  • Serra Vich, Francisca
  • Palou March, Andreu

Abstract

The present invention relates to a cocrystal of beta-sitosterol or a pharmaceutically acceptable ester thereof or an edible acceptable ester thereof and an organic carboxylic acid coformer, an hydrate crystal form of beta-sitosterol having 1.25 molecules of water per molecule of beta-sitosterol and a combination that comprises a cocrystal of beta-sitosterol and an organic carboxylic acid; and the hydrate crystal form of beta-sitosterol having 1.25 molecules of water per molecule of beta-sitosterol. It also relates to processes for their preparation, and compositions containing them, as well as their use as a medicament or dietary supplement or functional food, and in particular in the prophylaxis and/or treatment of a disease or conditions that involves an alteration of lipid metabolism, circulating levels of lipids in the blood and/or lipid composition in tissues and organs.

IPC Classes  ?

  • A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
  • A61P 3/06 - Antihyperlipidemics
  • C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

18.

CRYSTALLINE FORMS OF BETA-SITOSTEROL

      
Application Number EP2018066745
Publication Number 2018/234540
Status In Force
Filing Date 2018-06-22
Publication Date 2018-12-27
Owner
  • CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (Spain)
  • ALIMENTOMICA, S.L. (Spain)
Inventor
  • Prohens López, Rafel
  • Barbas Cañero, Rafael
  • Portell Bueso, Anna
  • Palou March, Mariona
  • Serra Vich, Francisca
  • Palou March, Andreu

Abstract

The present invention relates to a cocrystal of beta-sitosterol or a pharmaceutically acceptable ester thereof or an edible acceptable ester thereof and an organic carboxylic acid coformer, an hydrate crystal form of beta-sitosterol having 1.25 molecules of water per molecule of beta-sitosterol and a combination that comprises a cocrystal of beta-sitosterol and an organic carboxylic acid; and the hydrate crystal form of beta-sitosterol having 1.25 molecules of water per molecule of beta-sitosterol. It also relates to processes for their preparation, and compositions containing them, as well as their use as a medicament or dietary supplement or functional food, and in particular in the prophylaxis and/or treatment of a disease or conditions that involves an alteration of lipid metabolism, circulating levels of lipids in the blood and/or lipid composition in tissues and organs.

IPC Classes  ?

  • C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
  • A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
  • A61P 3/06 - Antihyperlipidemics