Abstract

An object of the present invention is to provide a pharmaceutical composition for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease. The present invention provides a pharmaceutical composition containing a specific self-assembling peptide RADA16 for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

An object of the present invention is to provide a pharmaceutical composition for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease. The present invention provides a pharmaceutical composition containing a specific self-assembling peptide RADA16 for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

A retroreflective material having high retroreflective performance while being edible is provided with a reflector main body that has optical transparency. The reflector main body is formed from agar. One side of the reflector main body constitutes an incident surface where incident light enters into the reflector main body. The other side of the reflector main body is formed as a retroreflective surface that reflects incident light that has entered to an inner part of the reflector main body in a direction substantially parallel to an incident direction.

IPC Classes  ?

• G02B 5/124 - Reflex reflectors cube corner, trihedral or triple reflector type plural reflecting elements forming part of a unitary plate or sheet

Abstract

The present invention provides a novel nucleic acid molecule that can be used for detection of α-amylase. The α-amylase-binding nucleic acid molecule of the present invention is characterized in that it binds to α-amylase with a dissociation constant of 17 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 22, for example. According to the nucleic acid molecule of the present invention, it is possible to detect α-amylase in saliva.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/40 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving amylase
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The present invention provides an edible retroreflective material exhibiting high retroreflective performance. The retroreflective material includes a translucent reflective material body 10. The reflective material body 10 is made up of an agar. One surface of the reflective material body 10 constitutes a light incidence surface 20 that allows incidence light to enter the reflective material body 10. The other surface of the reflective material body 10 constitutes a retroreflective surface 30 that reflects the incidence light entering the reflective material body 10 in a direction substantially parallel to the incidence direction.

IPC Classes  ?

• G02B 5/124 - Reflex reflectors cube corner, trihedral or triple reflector type plural reflecting elements forming part of a unitary plate or sheet
• A23L 5/00 - Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
• A23L 29/256 - Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan

Abstract

The current disclosure relates to a novel therapeutic strategy for patients with hypertriglyceridemia and/or chylomicronemia, wherein the patient is determined to have autoantibodies to GPIHBP1. It was unexpectedly found that autoantibodies to GPIHBP1, a GPI anchored protein of capillary endothelial cells that shuttles lipoprotein lipase to its site of action in the capillary lumen, were found to be present in patients with hypertriglyceridemia, and that the autoantibodies blocked the binding of lipoprotein lipase (LPL) to GPIHBP1. Accordingly, aspects of the disclosure relate to a method for treating hypertriglyceridemia and/or chylomicronemia in a patient comprising administering a therapeutically effective amount of an immunosuppressive treatment and/or GPIHBP1 activator to the patient; wherein the patient has been determined to have GPIHBP1 autoantibodies.

IPC Classes  ?

• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 49/14 - Peptides, e.g. proteins

Abstract

Provided is a novel nucleic acid molecule that is usable for detecting α-amylase. The nucleic acid molecule according to the present invention that is capable of binding to α-amylase is characterized by having a dissociation constant to α-amylase of not more than 17 nM. The nucleic acid molecule preferably contains, for example, a polynucleotide comprising a base sequence represented by any of SEQ ID NOS: 1 to 22. By using the nucleic acid molecule according to the present invention, α-amylase in saliva can be detected.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12N 15/09 - Recombinant DNA-technology
• C12Q 1/40 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving amylase
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

Provided are a water-blocking filler, the swelling properties of which do not decrease easily even when in contact with water containing calcium ions, and a filler for engineered multi-barriers with said water-blocking filler as the engineered multi-barrier filler. A water-blocking filler mainly comprising sodium bentonite obtained by mixing 30 weight % or less, in terms of inner percentage, of a pozzolan substance such as fly ash or silica fume with said bentonite, and a filler using said water-blocking filler that is used for engineered multi-barriers in radioactive waste disposal facilities.

IPC Classes  ?

• B01J 20/12 - Naturally occurring clays or bleaching earth
• G21F 9/34 - Disposal of solid waste
• G21F 9/36 - Disposal of solid waste by baling
• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• G21F 9/16 - Processing by fixation in stable solid media

Abstract

Provided are a water-blocking filler, the swelling properties of which do not decrease easily even when in contact with water containing calcium ions, and a filler for manmade multi-barriers with said water-blocking filler as the manmade multi-barrier filler. A water-blocking filler mainly comprising sodium bentonite obtained by mixing 30 weight% or less, in terms of inner percentage, of a pozzolan substance such as fly ash or silica fume with said bentonite, and a filler using said water-blocking filler that is used for manmade multi-barriers in radioactive waste disposal facilities.

IPC Classes  ?

• C09K 3/10 - Materials not provided for elsewhere for sealing or packing joints or covers
• C09K 17/02 - Soil-conditioning materials or soil-stabilising materials containing inorganic compounds only
• C09K 17/08 - Aluminium compounds, e.g. aluminium hydroxide
• G21F 9/34 - Disposal of solid waste
• G21F 9/36 - Disposal of solid waste by baling

Abstract

The disclosed method for producing a microstructure can form a complicated three-dimensionally formed microstructure with few steps. A first mask pattern (22) containing a light transmitting section and a light blocking section is disposed along an unexposed photosensitive resin (42), and a second mask pattern (32) containing a light transmitting section and a light blocking section is disposed on the reverse side of the first mask pattern (22) from the photosensitive resin (42). Additionally, by means of integrally rotating the photosensitive resin (42) and the first mask pattern (22) around a central axis (Z) that passes through the photosensitive resin (42) and the first mask pattern (22), and at the same time radiating exposure light from the reverse side of the second mask pattern (32) from the photosensitive resin (42) and the first mask pattern (22) in a direction that is inclined obliquely with respect to the direction of the central axis (Z), the light beam of the exposure light that is transmitted through the light transmitting section of the second mask pattern (32) and the light transmitting section of the first mask pattern (22) exposes the photosensitive resin (42).

IPC Classes  ?

• G03F 7/20 - Exposure; Apparatus therefor
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
• B81C 99/00 - Subject matter not provided for in other groups of this subclass
• G03F 1/00 - Originals for photomechanical production of textured or patterned surfaces, e.g. masks, photo-masks or reticles; Mask blanks or pellicles therefor; Containers specially adapted therefor; Preparation thereof
• G03F 1/38 - Masks having auxiliary features, e.g. special coatings or marks for alignment or testing; Preparation thereof

Abstract

A transform spectrometer measurement apparatus and method for a planar waveguide circuit (PLC). The spectrometer typically includes an input optical signal waveguide carrying an input optical signal; a plurality of couplers, each connected to the input optical signal waveguide, and each including a coupler output for carrying a coupled optical signal related to the input optical signal; and an array of interleaved, waveguide Mach-Zehnder interferometers (MZI), each having at least one input MZI waveguide, each MZI input waveguide receiving a coupled optical signal from a respective coupler output. A phase shifting circuit is applied to at least one arm of the MZIs to induce an active phase shift on the arm to thereby measure phase error in the MZIs. Light output from the MZIs is measured under intrinsic phase error conditions and after an active phase shift by the phase shifting circuit.

IPC Classes  ?

• G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
• G06F 17/14 - Fourier, Walsh or analogous domain transformations

Abstract

The problem of the decline in quality of a low-diffusion layer (4) due to the leaching out of calcium ions from said layer (4) and the problem of reduced performance and change in quality of a low water-permeability layer (5) due to conversion of sodium type bentonite to the calcium type are resolved in an artificial multi-barrier for a radioactive waste treatment facility wherein a low-diffusion layer (4) comprising cement-based material and a low water-permeability layer (5) having sodium type bentonite as the main component are in contact.  A concrete pit (3) housing radioactive waste (2) is established in a tunnel (1), the low-diffusion layer (4) comprising cement-based material is arranged on the outside, and the low water-permeability layer (5) is arranged on the outside of said low-diffusion layer.  Sodium bicarbonate at a concentration supersaturating the mixing water or sodium carbonate exceeding the saturation concentration in the mixing water is mixed with the sodium-type bentonite/sand mixture of the low water-permeability layer (5) and when calcium ions leach out from the low diffusion layer (4), a barrier layer having calcium carbonate as the main component is formed in the vicinity of the interface between the low-diffusion layer (4) and the low water-permeability layer (5).

IPC Classes  ?

• G21F 9/36 - Disposal of solid waste by baling