PHARMACEUTICAL COMPOSITION CONTAINING SPECIFIC SELF-ASSEMBLING PEPTIDE RADA16 FOR TREATING OR PREVENTING LOWER GASTROINTESTINAL DISEASES SUCH AS INFLAMMATORY BOWEL DISEASE
An object of the present invention is to provide a pharmaceutical composition for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease. The present invention provides a pharmaceutical composition containing a specific self-assembling peptide RADA16 for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease.
A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61K 47/36 - Polysaccharides; Leurs dérivés, p.ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p.ex. antiacides, antisécrétoires, protecteurs de la muqueuse
2.
PHARMACEUTICAL COMPOSITION CONTAINING SPECIFIC SELF-ASSEMBLING PEPTIDE RADA16 FOR TREATING OR PREVENTING LOWER GASTROINTESTINAL DISEASES SUCH AS INFLAMMATORY BOWEL DISEASE
An object of the present invention is to provide a pharmaceutical composition for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease. The present invention provides a pharmaceutical composition containing a specific self-assembling peptide RADA16 for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease.
A retroreflective material having high retroreflective performance while being edible is provided with a reflector main body that has optical transparency. The reflector main body is formed from agar. One side of the reflector main body constitutes an incident surface where incident light enters into the reflector main body. The other side of the reflector main body is formed as a retroreflective surface that reflects incident light that has entered to an inner part of the reflector main body in a direction substantially parallel to an incident direction.
G02B 5/124 - Réflecteurs reflex du type en sommet de cube, en trièdre ou en réflecteur triple plusieurs éléments réfléchissants faisant partie d'une plaque ou d'une feuille formant un tout
4.
α-amylase-binding nucleic acid molecule and use thereof
The present invention provides a novel nucleic acid molecule that can be used for detection of α-amylase. The α-amylase-binding nucleic acid molecule of the present invention is characterized in that it binds to α-amylase with a dissociation constant of 17 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 22, for example. According to the nucleic acid molecule of the present invention, it is possible to detect α-amylase in saliva.
C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
C12N 15/115 - Aptamères, c. à d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
C12Q 1/40 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase une amylase
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
The present invention provides an edible retroreflective material exhibiting high retroreflective performance. The retroreflective material includes a translucent reflective material body 10. The reflective material body 10 is made up of an agar. One surface of the reflective material body 10 constitutes a light incidence surface 20 that allows incidence light to enter the reflective material body 10. The other surface of the reflective material body 10 constitutes a retroreflective surface 30 that reflects the incidence light entering the reflective material body 10 in a direction substantially parallel to the incidence direction.
G02B 5/124 - Réflecteurs reflex du type en sommet de cube, en trièdre ou en réflecteur triple plusieurs éléments réfléchissants faisant partie d'une plaque ou d'une feuille formant un tout
A23L 5/00 - Préparation ou traitement des aliments ou produits alimentaires en général; Aliments ou produits alimentaires ainsi obtenus; Leurs matériaux
A23L 29/256 - Aliments ou produits alimentaires contenant des additifs; Leur préparation ou leur traitement contenant des agents gélifiants ou épaississants d'origine végétale à base d'algues, p.ex. alginates, agar-agar ou carraghénane
6.
METHODS AND COMPOSITIONS FOR TREATING HYPERTRIGLYCERIDEMIA
The current disclosure relates to a novel therapeutic strategy for patients with hypertriglyceridemia and/or chylomicronemia, wherein the patient is determined to have autoantibodies to GPIHBP1. It was unexpectedly found that autoantibodies to GPIHBP1, a GPI anchored protein of capillary endothelial cells that shuttles lipoprotein lipase to its site of action in the capillary lumen, were found to be present in patients with hypertriglyceridemia, and that the autoantibodies blocked the binding of lipoprotein lipase (LPL) to GPIHBP1. Accordingly, aspects of the disclosure relate to a method for treating hypertriglyceridemia and/or chylomicronemia in a patient comprising administering a therapeutically effective amount of an immunosuppressive treatment and/or GPIHBP1 activator to the patient; wherein the patient has been determined to have GPIHBP1 autoantibodies.
Provided is a novel nucleic acid molecule that is usable for detecting α-amylase. The nucleic acid molecule according to the present invention that is capable of binding to α-amylase is characterized by having a dissociation constant to α-amylase of not more than 17 nM. The nucleic acid molecule preferably contains, for example, a polynucleotide comprising a base sequence represented by any of SEQ ID NOS: 1 to 22. By using the nucleic acid molecule according to the present invention, α-amylase in saliva can be detected.
C12Q 1/40 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase une amylase
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
8.
Water-blocking filler and filler for engineered multi-barriers using said water-blocking filler
Provided are a water-blocking filler, the swelling properties of which do not decrease easily even when in contact with water containing calcium ions, and a filler for engineered multi-barriers with said water-blocking filler as the engineered multi-barrier filler. A water-blocking filler mainly comprising sodium bentonite obtained by mixing 30 weight % or less, in terms of inner percentage, of a pozzolan substance such as fly ash or silica fume with said bentonite, and a filler using said water-blocking filler that is used for engineered multi-barriers in radioactive waste disposal facilities.
Provided are a water-blocking filler, the swelling properties of which do not decrease easily even when in contact with water containing calcium ions, and a filler for manmade multi-barriers with said water-blocking filler as the manmade multi-barrier filler. A water-blocking filler mainly comprising sodium bentonite obtained by mixing 30 weight% or less, in terms of inner percentage, of a pozzolan substance such as fly ash or silica fume with said bentonite, and a filler using said water-blocking filler that is used for manmade multi-barriers in radioactive waste disposal facilities.
The disclosed method for producing a microstructure can form a complicated three-dimensionally formed microstructure with few steps.
A first mask pattern (22) containing a light transmitting section and a light blocking section is disposed along an unexposed photosensitive resin (42), and a second mask pattern (32) containing a light transmitting section and a light blocking section is disposed on the reverse side of the first mask pattern (22) from the photosensitive resin (42). Additionally, by means of integrally rotating the photosensitive resin (42) and the first mask pattern (22) around a central axis (Z) that passes through the photosensitive resin (42) and the first mask pattern (22), and at the same time radiating exposure light from the reverse side of the second mask pattern (32) from the photosensitive resin (42) and the first mask pattern (22) in a direction that is inclined obliquely with respect to the direction of the central axis (Z), the light beam of the exposure light that is transmitted through the light transmitting section of the second mask pattern (32) and the light transmitting section of the first mask pattern (22) exposes the photosensitive resin (42).
G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
B81C 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
G03F 1/00 - Originaux pour la production par voie photomécanique de surfaces texturées, p.ex. masques, photomasques ou réticules; Masques vierges ou pellicules à cet effet; Réceptacles spécialement adaptés à ces originaux; Leur préparation
G03F 1/38 - Masques à caractéristiques supplémentaires, p.ex. marquages pour l'alignement ou les tests, ou couches particulières; Leur préparation
11.
PLANAR LIGHTWAVE FOURIER-TRANSFORM SPECTROMETER MEASUREMENT INCLUDING PHASE SHIFTING FOR ERROR CORRECTION
A transform spectrometer measurement apparatus and method for a planar waveguide circuit (PLC). The spectrometer typically includes an input optical signal waveguide carrying an input optical signal; a plurality of couplers, each connected to the input optical signal waveguide, and each including a coupler output for carrying a coupled optical signal related to the input optical signal; and an array of interleaved, waveguide Mach-Zehnder interferometers (MZI), each having at least one input MZI waveguide, each MZI input waveguide receiving a coupled optical signal from a respective coupler output. A phase shifting circuit is applied to at least one arm of the MZIs to induce an active phase shift on the arm to thereby measure phase error in the MZIs. Light output from the MZIs is measured under intrinsic phase error conditions and after an active phase shift by the phase shifting circuit.
The problem of the decline in quality of a low-diffusion layer (4) due to the leaching out of calcium ions from said layer (4) and the problem of reduced performance and change in quality of a low water-permeability layer (5) due to conversion of sodium type bentonite to the calcium type are resolved in an artificial multi-barrier for a radioactive waste treatment facility wherein a low-diffusion layer (4) comprising cement-based material and a low water-permeability layer (5) having sodium type bentonite as the main component are in contact. A concrete pit (3) housing radioactive waste (2) is established in a tunnel (1), the low-diffusion layer (4) comprising cement-based material is arranged on the outside, and the low water-permeability layer (5) is arranged on the outside of said low-diffusion layer. Sodium bicarbonate at a concentration supersaturating the mixing water or sodium carbonate exceeding the saturation concentration in the mixing water is mixed with the sodium-type bentonite/sand mixture of the low water-permeability layer (5) and when calcium ions leach out from the low diffusion layer (4), a barrier layer having calcium carbonate as the main component is formed in the vicinity of the interface between the low-diffusion layer (4) and the low water-permeability layer (5).
brevets
