The continuous liquid separation is a continuous liquid separating apparatus that separates a first liquid and a second liquid that is immiscible to the first liquid and has a higher specific gravity than the first liquid, and includes: a liquid separating tank configured to contain a liquid, and be supplied with a liquid mixture of the first liquid and the second liquid, and including a first discharge portion on a lower side thereof and a second discharge portion disposed at a position higher than the first discharge portion, a valve configured to open/close the first discharge portion, a first sensor configured to detect a first water level of the liquid mixture contained in the liquid separating tank, the first water level being lower than the second discharge portion, and a second sensor configured to detect a second water level of the liquid mixture contained in the liquid separating tank.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
30 - Basic staples, tea, coffee, baked goods and confectionery
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals; industrial chemicals; chemicals used in science;
plant extracts for use in the manufacture of
pharmaceuticals; plant extracts for use in the manufacture
of cosmetics; plant extracts for use in the manufacture of
food; chemical additives for use in the manufacture of food;
animal extracts for use in manufacture of pharmaceuticals;
animal extracts for use in manufacture of cosmetics; animal
extracts for use in the manufacture of foods; glues and
adhesives for industrial purposes; plant growth regulating
preparations; chemicals used in agriculture, horticulture
and forestry; fertilizers; ceramic glazings; oil cement
[putty]; higher fatty acids; fatty acids for industrial
purpose; non-metallic minerals; non-metallic minerals for
use in manufacture; photographic chemicals; photographic
developers; reagent paper [not for medical purposes];
reagent paper, other than for medical or veterinary
purposes; artificial sweeteners; artificial sweeteners
[chemical preparations]; flour and starch for industrial
purposes; plastics [raw materials]; plastics, unprocessed;
paper pulp, cellulose pulp, wood pulp; paper pulp;
dissolving pulp. Anti-static preparations for household purposes; de-greasing
preparations for household purposes; rust removing
preparations; stain removing benzine; fabric softeners for
laundry use; laundry bleach; adhesives for affixing false
hair; laundry starch; seaweed gelatine for laundry use
[Funori]; adhesives for affixing false eyelashes; breath
freshening preparations; breath freshening preparations for
personal hygiene; deodorants for animals; paint stripping
preparations; shoe cream; shoe black [shoe polish];
polishing preparations; soaps and detergents; bar soap; bath
soaps; liquid soap; detergent soap; detergents for household
use; dentifrices; cosmetics; perfumes and fragrances;
perfumes; perfumes for industrial purposes; essential oils
for use as food and drink flavorings; essential oils; body
deodorant cosmetics and fragrances; fragrances; incense;
abrasive paper; abrasive cloth; abrasive sand; artificial
pumice stone; polishing paper; false nails; false eyelashes. Pharmaceutical preparations and other preparations for
destroying vermin, fungicides, herbicides; pharmaceutical
preparations; pharmaceutical, medical and veterinary
preparations; chemical reagents for medical or veterinary
purposes; vitamin preparations; nutritional additives;
disinfectants; preparations for destroying vermin;
fungicides; herbicides; plant extracts for pharmaceutical
purposes; nutritional supplement drinks; nursing tonic
nutritional supplement drinks; nutritional supplement
beverage; reagent paper for medical purposes; oiled paper
for medical purposes; adhesive tapes for medical purposes;
drug delivery agents in the form of edible wafers for
wrapping powdered pharmaceuticals; gauze for dressings;
empty capsules for pharmaceuticals; eyepatches for medical
purposes; ear bandages; menstruation bandages; menstruation
tampons; sanitary napkins; sanitary panties; absorbent
cotton; adhesive plasters; bandages for dressings; liquid
bandages; liquid bandages for skin wounds; breast-nursing
pads; cotton swabs for medical use; dental materials;
diapers; diaper covers; mothproofing paper; lacteal flour
for babies; dietary supplements for humans; dietary
supplements for human consumption; dietary food supplements;
dietetic beverages adapted for medical purposes; dietetic
foods adapted for medical purposes; dietetic substances for
medical use; dietetic substances adapted for medical use;
dietetic food and substances adapted for medical or
veterinary use; dietetic food and substances adapted for
medical or veterinary use, food for babies; beverages for
babies; food for babies; dietary supplements for animals;
nutritional supplements for animals; dietary foods
supplements for pets; dietary foods supplements for
livestock feed; dietary foods supplements for wild animals;
dietary foods supplements for sea animals; dietary foods
supplements for fish; semen for artificial insemination;
propolis dietary supplements. Binding agents for ice cream; meat tenderizers for household
purposes; preparations for stiffening whipped cream;
aromatic preparations for food, not from essential oils;
aromatic preparations for food; aromatic preparations being
flavourings for drinks, not from essential oils; aromatic
preparations being flavourings for drinks; tea; prepared
coffee and coffee-based beverages; coffee; coffee-based
beverages; coffee substitutes; prepared cocoa and
cocoa-based beverages; cocoa; cocoa-based beverages;
confectionery other than fruit-based, vegetable-based,
bean-based or nut-based; chocolate desserts, muesli
desserts, custard-based desserts, ice cream desserts;
cereal-based, chocolate-based and rice-based snacks;
confectionery; bread and buns; sandwiches; steamed buns
stuffed with minced meat [Chuka-manjuh]; hamburgers
[sandwiches]; hamburger sandwiches; pizzas; hot dogs
[sandwiches]; hot dogs sandwiches; meat pies; seasonings
[other than spices]; seasonings; sauces [condiments]; miso;
worcester sauce; meat gravies; ketchup; tomato ketchup;
ketchup (sauce); soy sauce [soya sauce]; soy sauce; soya
sauce; vinegar; vinegar mixes; vinegar base; seasoning soy
sauce [Sobatsuyu]; salad dressings; white sauce; bechamel
[white sauce]; mayonnaise; sauces for barbecued meat;
barbecue sauce; cube sugar; fructose for culinary purposes;
crystal sugar [not confectionery]; sugar; maltose for
culinary purposes; maltose; honey; glucose for culinary
purposes; powdered starch syrup for culinary purposes;
powdered candy; starch syrup for culinary purposes; table
salt mixed with sesame seeds; cooking salt; roasted and
ground sesame seeds; celery salt; umami seasonings; spices;
ice cream mixes; sherbet mixes [ices]; cereal preparations;
chocolate spread; chocolate-based spreads; yeast powder;
Koji [fermented malted rice]; yeast; baking powder; instant
confectionery mixes; pasta sauce; by-product of rice for
food [Sake lees]; husked rice; husked oats; husked barley;
gluten for food; gluten prepared as foodstuff; flour;
propolis; royal jelly. Food processing; processing of foodstuffs for use in
manufacture; plant extraction being services of biological
materials treatment; animal extraction being services of
biological materials treatment; fruit crushing; processing
of raw materials for the manufacture of functional foods;
custom manufacture of dietary supplements; custom
manufacture of dietary supplements for human beings;
processing of raw materials for the manufacture of food and
beverages; processing of raw materials for the manufacture
of cosmetics; processing of chemicals; processing of raw
materials for the manufacture of pharmaceuticals; custom
manufacture of pharmaceuticals; custom manufacture of
products for the pharmaceutical, chemical and food
industries by compressing and compacting powders and
granules; processing of artificial limbs or artificial
teeth, including processing of medical materials; water
treating; recycling of waste; rental of machines and
apparatus for processing foods or beverages; rental of water
purifying apparatus; rental of chemical processing machines
and apparatus; providing material treatment information;
custom manufacture of pharmaceutical raw materials; custom
manufacture of drug substance; custom manufacture of
pharmaceutical intermediate; custom manufacture of
pharmaceutical additives; custom manufacture of
pharmaceutical ingredients; custom manufacture of chemicals;
custom manufacture of cosmetics; custom manufacture of
cosmetic ingredients; custom processing of foods, other than
cooking; custom processing of ingredients for food industry;
custom manufacture of medical materials; custom manufacture
of amino acids; custom manufacture of active pharmaceutical
ingredients; custom manufacture of biopharmaceuticals. Providing meteorological information; architectural design;
surveying; geological surveys or research; geological
surveys; geological research; designing of machines,
apparatus, instruments [including their parts] or systems
composed of such machines, apparatus and instruments;
designing, other than for advertising purposes; computer
software design, computer programming, or maintenance of
computer software; computer software design; computer
programming; maintenance of computer software; technological
advice relating to computers, automobiles and industrial
machines; testing, inspection or research of
pharmaceuticals, cosmetics or foodstuffs; pharmaceutical
research service; pharmaceutical research; medical research;
testing, inspection or research of pharmaceutical raw
materials; research of pharmaceutical production methods;
testing, inspection or research of drug substance; research
of drug substance production methods; testing, inspection or
research of pharmaceutical intermediate; research of
pharmaceutical intermediate production method; testing,
inspection or research of pharmaceutical additives; research
of pharmaceutical additive production methods; testing,
inspection or research of pharmaceutical ingredients;
research of pharmaceutical ingredient production methods;
testing, inspection or research of chemicals; chemical
analysis; chemical research; research of chemical production
methods; development and test of chemical production
methods; testing, inspection or research of cosmetics;
research of cosmetic production methods; laboratory research
in the field of cosmetics; laboratory analysis in the field
of cosmetics; testing, inspection or research of cosmetic
ingredients; research of cosmetic ingredient production
methods; testing, inspection or research of foodstuffs; food
research; research on food; research in the field of food;
research of foodstuff production methods; testing,
inspection or research of foodstuff ingredients; research of
foodstuff ingredient production methods; testing, inspection
or research of medical materials; research of medical
material production methods; testing, inspection or research
in the field of pharmaceutical, chemical and food
industries; research of production methods in the field of
pharmaceutical, chemical and food industries; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; research on
building construction or city planning; testing or research
on prevention of pollution; testing or research on
electricity; testing or research on civil engineering;
testing, inspection or research of agriculture, livestock
breeding or fisheries; testing or research on machines,
apparatus and instruments; rental of measuring apparatus;
rental of computers; providing computer programs on data
networks; rental of laboratory apparatus and instruments;
rental of technical drawing instruments; design and
development of new technology for others; scientific
research and development; scientific and medical research
and development; provision of information and data relating
to scientific and technological research and development;
research and development of new products for others; product
development for others.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
30 - Basic staples, tea, coffee, baked goods and confectionery
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals; industrial chemicals; chemicals used in science;
plant extracts for use in the manufacture of
pharmaceuticals; plant extracts for use in the manufacture
of cosmetics; plant extracts for use in the manufacture of
food; chemical additives for use in the manufacture of food;
animal extracts for use in manufacture of pharmaceuticals;
animal extracts for use in manufacture of cosmetics; animal
extracts for use in the manufacture of foods; glues and
adhesives for industrial purposes; plant growth regulating
preparations; chemicals used in agriculture, horticulture
and forestry; fertilizers; ceramic glazings; oil cement
[putty]; higher fatty acids; fatty acids for industrial
purpose; non-metallic minerals; non-metallic minerals for
use in manufacture; photographic chemicals; photographic
developers; reagent paper [not for medical purposes];
reagent paper, other than for medical or veterinary
purposes; artificial sweeteners; artificial sweeteners
[chemical preparations]; flour and starch for industrial
purposes; plastics [raw materials]; plastics, unprocessed;
paper pulp, cellulose pulp, wood pulp; paper pulp;
dissolving pulp. Anti-static preparations for household purposes; de-greasing
preparations for household purposes; rust removing
preparations; stain removing benzine; fabric softeners for
laundry use; laundry bleach; adhesives for affixing false
hair; laundry starch; seaweed gelatine for laundry use
[Funori]; adhesives for affixing false eyelashes; breath
freshening preparations; breath freshening preparations for
personal hygiene; deodorants for animals; paint stripping
preparations; shoe cream; shoe black [shoe polish];
polishing preparations; soaps and detergents; bar soap; bath
soaps; liquid soap; detergent soap; detergents for household
use; dentifrices; cosmetics; perfumes and fragrances;
perfumes; perfumes for industrial purposes; essential oils
for use as food and drink flavorings; essential oils; body
deodorant cosmetics and fragrances; fragrances; incense;
abrasive paper; abrasive cloth; abrasive sand; artificial
pumice stone; polishing paper; false nails; false eyelashes. Pharmaceutical preparations and other preparations for
destroying vermin, fungicides, herbicides; pharmaceutical
preparations; pharmaceutical, medical and veterinary
preparations; chemical reagents for medical or veterinary
purposes; vitamin preparations; nutritional additives;
disinfectants; preparations for destroying vermin;
fungicides; herbicides; plant extracts for pharmaceutical
purposes; nutritional supplement drinks; nursing tonic
nutritional supplement drinks; nutritional supplement
beverage; reagent paper for medical purposes; oiled paper
for medical purposes; adhesive tapes for medical purposes;
drug delivery agents in the form of edible wafers for
wrapping powdered pharmaceuticals; gauze for dressings;
empty capsules for pharmaceuticals; eyepatches for medical
purposes; ear bandages; menstruation bandages; menstruation
tampons; sanitary napkins; sanitary panties; absorbent
cotton; adhesive plasters; bandages for dressings; liquid
bandages; liquid bandages for skin wounds; breast-nursing
pads; cotton swabs for medical use; dental materials;
diapers; diaper covers; mothproofing paper; lacteal flour
for babies; dietary supplements for humans; dietary
supplements for human consumption; dietary food supplements;
dietetic beverages adapted for medical purposes; dietetic
foods adapted for medical purposes; dietetic substances for
medical use; dietetic substances adapted for medical use;
dietetic food and substances adapted for medical or
veterinary use; dietetic food and substances adapted for
medical or veterinary use, food for babies; beverages for
babies; food for babies; dietary supplements for animals;
nutritional supplements for animals; dietary foods
supplements for pets; dietary foods supplements for
livestock feed; dietary foods supplements for wild animals;
dietary foods supplements for sea animals; dietary foods
supplements for fish; semen for artificial insemination;
propolis dietary supplements. Binding agents for ice cream; meat tenderizers for household
purposes; preparations for stiffening whipped cream;
aromatic preparations for food, not from essential oils;
aromatic preparations for food; aromatic preparations being
flavourings for drinks, not from essential oils; aromatic
preparations being flavourings for drinks; tea; prepared
coffee and coffee-based beverages; coffee; coffee-based
beverages; coffee substitutes; prepared cocoa and
cocoa-based beverages; cocoa; cocoa-based beverages;
confectionery other than fruit-based, vegetable-based,
bean-based or nut-based; chocolate desserts, muesli
desserts, custard-based desserts, ice cream desserts;
cereal-based, chocolate-based and rice-based snacks;
confectionery; bread and buns; sandwiches; steamed buns
stuffed with minced meat [Chuka-manjuh]; hamburgers
[sandwiches]; hamburger sandwiches; pizzas; hot dogs
[sandwiches]; hot dogs sandwiches; meat pies; seasonings
[other than spices]; seasonings; sauces [condiments]; miso;
worcester sauce; meat gravies; ketchup; tomato ketchup;
ketchup (sauce); soy sauce [soya sauce]; soy sauce; soya
sauce; vinegar; vinegar mixes; vinegar base; seasoning soy
sauce [Sobatsuyu]; salad dressings; white sauce; bechamel
[white sauce]; mayonnaise; sauces for barbecued meat;
barbecue sauce; cube sugar; fructose for culinary purposes;
crystal sugar [not confectionery]; sugar; maltose for
culinary purposes; maltose; honey; glucose for culinary
purposes; powdered starch syrup for culinary purposes;
powdered candy; starch syrup for culinary purposes; table
salt mixed with sesame seeds; cooking salt; roasted and
ground sesame seeds; celery salt; umami seasonings; spices;
ice cream mixes; sherbet mixes [ices]; cereal preparations;
chocolate spread; chocolate-based spreads; yeast powder;
Koji [fermented malted rice]; yeast; baking powder; instant
confectionery mixes; pasta sauce; by-product of rice for
food [Sake lees]; husked rice; husked oats; husked barley;
gluten for food; gluten prepared as foodstuff; flour;
propolis; royal jelly. Food processing; processing of foodstuffs for use in
manufacture; plant extraction being services of biological
materials treatment; animal extraction being services of
biological materials treatment; fruit crushing; processing
of raw materials for the manufacture of functional foods;
custom manufacture of dietary supplements; custom
manufacture of dietary supplements for human beings;
processing of raw materials for the manufacture of food and
beverages; processing of raw materials for the manufacture
of cosmetics; processing of chemicals; processing of raw
materials for the manufacture of pharmaceuticals; custom
manufacture of pharmaceuticals; custom manufacture of
products for the pharmaceutical, chemical and food
industries by compressing and compacting powders and
granules; processing of artificial limbs or artificial
teeth, including processing of medical materials; water
treating; recycling of waste; rental of machines and
apparatus for processing foods or beverages; rental of water
purifying apparatus; rental of chemical processing machines
and apparatus; providing material treatment information;
custom manufacture of pharmaceutical raw materials; custom
manufacture of drug substance; custom manufacture of
pharmaceutical intermediate; custom manufacture of
pharmaceutical additives; custom manufacture of
pharmaceutical ingredients; custom manufacture of chemicals;
custom manufacture of cosmetics; custom manufacture of
cosmetic ingredients; custom processing of foods, other than
cooking; custom processing of ingredients for food industry;
custom manufacture of medical materials; custom manufacture
of amino acids; custom manufacture of active pharmaceutical
ingredients; custom manufacture of biopharmaceuticals. Providing meteorological information; architectural design;
surveying; geological surveys or research; geological
surveys; geological research; designing of machines,
apparatus, instruments [including their parts] or systems
composed of such machines, apparatus and instruments;
designing, other than for advertising purposes; computer
software design, computer programming, or maintenance of
computer software; computer software design; computer
programming; maintenance of computer software; technological
advice relating to computers, automobiles and industrial
machines; testing, inspection or research of
pharmaceuticals, cosmetics or foodstuffs; pharmaceutical
research service; pharmaceutical research; medical research;
testing, inspection or research of pharmaceutical raw
materials; research of pharmaceutical production methods;
testing, inspection or research of drug substance; research
of drug substance production methods; testing, inspection or
research of pharmaceutical intermediate; research of
pharmaceutical intermediate production method; testing,
inspection or research of pharmaceutical additives; research
of pharmaceutical additive production methods; testing,
inspection or research of pharmaceutical ingredients;
research of pharmaceutical ingredient production methods;
testing, inspection or research of chemicals; chemical
analysis; chemical research; research of chemical production
methods; development and test of chemical production
methods; testing, inspection or research of cosmetics;
research of cosmetic production methods; laboratory research
in the field of cosmetics; laboratory analysis in the field
of cosmetics; testing, inspection or research of cosmetic
ingredients; research of cosmetic ingredient production
methods; testing, inspection or research of foodstuffs; food
research; research on food; research in the field of food;
research of foodstuff production methods; testing,
inspection or research of foodstuff ingredients; research of
foodstuff ingredient production methods; testing, inspection
or research of medical materials; research of medical
material production methods; testing, inspection or research
in the field of pharmaceutical, chemical and food
industries; research of production methods in the field of
pharmaceutical, chemical and food industries; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; research on
building construction or city planning; testing or research
on prevention of pollution; testing or research on
electricity; testing or research on civil engineering;
testing, inspection or research of agriculture, livestock
breeding or fisheries; testing or research on machines,
apparatus and instruments; rental of measuring apparatus;
rental of computers; providing computer programs on data
networks; rental of laboratory apparatus and instruments;
rental of technical drawing instruments; design and
development of new technology for others; scientific
research and development; scientific and medical research
and development; provision of information and data relating
to scientific and technological research and development;
research and development of new products for others; product
development for others.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals; industrial chemicals. Dietary supplements for humans; dietary supplements for
human consumption; dietary food supplements; dietary
supplements consisting of minerals; dietetic beverages
adapted for medical purposes; dietetic food adapted for
medical purposes; dietetic substances for medical use other
than pharmaceutical preparations; dietetic substances
adapted for medical use other than pharmaceutical
preparations; dietetic food and substances adapted for
medical or veterinary use other than pharmaceutical
preparations; dietetic food and substances adapted for
medical or veterinary use, food for babies other than
pharmaceutical preparations; beverages for babies; food for
babies; dietary supplements for animals; nutritional
supplements for animals; dietary food supplements for pets;
dietary food supplements for livestock feed; dietary foods
supplements for wild animals; dietary food supplements for
sea animals; dietary foods supplements for fish.
01 - Chemical and biological materials for industrial, scientific and agricultural use
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals; industrial chemicals; chemical used in science;
glue and adhesives for industrial purposes; plant growth
regulating preparations; chemical used in agriculture,
horticulture and forestry; fertilizers; ceramic glazings;
oil cement [putty]; higher fatty acids; fatty acids for
industrial purpose; non-metallic minerals; non-metallic
minerals for use in manufacture; photographic chemicals;
reagent paper [not for medical purposes]; reagent paper,
other than for medical or veterinary purposes; artificial
sweeteners; flour and starch for industrial purposes;
plastics [raw materials]; plastic, unprocessed; pulp; paper
pulp; dissolving pulp. Custom manufacture of pharmaceuticals; custom manufacture of
products for the pharmaceutical, chemical and food
industries by compressing and compacting powders and
granules; custom manufacture of pharmaceutical raw
materials; custom manufacture of drug substance; custom
manufacture of pharmaceutical intermediate; custom
manufacture of pharmaceutical additives; custom manufacture
of pharmaceutical ingredients; custom manufacture of
chemicals; custom manufacture of cosmetics; custom
manufacture of cosmetic ingredients; custom manufacture of
foods; custom manufacture of food ingredients; custom
manufacture of medical materials; custom manufacture of
amino acids; custom manufacture of active pharmaceutical
ingredients; custom manufacture of biopharmaceuticals. Testing, inspection or research of pharmaceuticals,
cosmetics or foodstuffs; pharmaceutical research services;
pharmaceutical research; medical research; testing,
inspection or research of pharmaceutical raw materials;
research of pharmaceutical production methods; testing,
inspection or research of drug substance; research of drug
substance production methods; testing, inspection or
research of pharmaceutical intermediate; research of
pharmaceutical intermediate production method; testing,
inspection or research of pharmaceutical additives; research
of pharmaceutical additive production methods; testing,
inspection or research of pharmaceutical ingredients;
research of pharmaceutical ingredient production methods;
testing, inspection or research of chemicals; chemical
analysis; chemical research; research of chemical production
methods; development and test of chemical production
methods; testing, inspection or research of cosmetics;
research of cosmetic production methods; laboratory research
in the field of cosmetics; laboratory analysis in the field
of cosmetics; testing, inspection or research of cosmetic
ingredients; research of cosmetic ingredient production
methods; testing, inspection or research of foodstuffs; food
research; research on food; research in the field of food;
research of foodstuff production methods; testing,
inspection or research of foodstuff ingredients; research of
foodstuff ingredient production methods; testing, inspection
or research of medical materials; research of medical
material production methods; testing, inspection or research
of pharmaceutical products and foods and drinks; research on
manufacturing methods for pharmaceutical products and foods
and drinks; testing, inspection or research on agriculture,
livestock breeding or fisheries; design and development of
new technology for others; scientific research and
development; scientific and medical research and
development; provision of information and data relating to
scientific and technological research and development;
research and development of new products for others; product
development for others.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemicals; industrial chemicals. Dietary supplements for humans; dietary supplements for
human consumption; dietary food supplements; dietary
supplements consisting of minerals; dietetic beverages
adapted for medical purposes; dietetic food adapted for
medical purposes; dietetic substances for medical use other
than pharmaceutical preparations; dietetic substances
adapted for medical use other than pharmaceutical
preparations; dietetic food and substances adapted for
medical or veterinary use other than pharmaceutical
preparations; dietetic food and substances adapted for
medical or veterinary, food for babies other than
pharmaceutical preparations; beverages for babies; food for
babies; dietary supplements for animals; nutritional
supplements for animals; dietary food supplements for pets;
dietary food supplements for livestock feed; dietary foods
supplements for wild animals; dietary food supplements for
sea animals; dietary foods supplements for fish.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Chemicals; industrial chemicals.
(2) Dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietary supplements consisting of minerals; dietetic beverages adapted for medical purposes; dietetic food adapted for medical purposes; dietetic substances for medical use other than pharmaceutical preparations; dietetic substances adapted for medical use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary, food for babies other than pharmaceutical preparations; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary food supplements for pets; dietary food supplements for livestock feed; dietary foods supplements for wild animals; dietary food supplements for sea animals; dietary foods supplements for fish.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Chemicals; industrial chemicals.
(2) Dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietary supplements consisting of minerals; dietetic beverages adapted for medical purposes; dietetic food adapted for medical purposes; dietetic substances for medical use other than pharmaceutical preparations; dietetic substances adapted for medical use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use, food for babies other than pharmaceutical preparations; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary food supplements for pets; dietary food supplements for livestock feed; dietary foods supplements for wild animals; dietary food supplements for sea animals; dietary foods supplements for fish.
An object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a large amount of a peptide. Another object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a high-purity long-chain peptide. Still another object of the present invention is to provide a novel solid phase peptide synthesis method causing fewer side reactions. The present invention relates to a method for producing a peptide, and the method comprises solid-phase synthesis of a peptide under stirring with a centrifugal stirrer having no impeller.
C07K 1/04 - General processes for the preparation of peptides on carriers
B01J 8/10 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with moving particles moved by stirrers or by rotary drums or rotary receptacles
B01F 7/32 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a vertical axis with openwork frames or cages
The present invention addresses the problem of providing a novel peptide solid-phase synthesis method for synthesizing a peptide in a large quantity. The present invention also addresses the problem of providing a novel peptide solid-phase synthesis method for synthesizing a long-chain peptide having high purity. The present invention also addresses the problem of providing a novel peptide solid-phase synthesis method which causes few side reactions. The present invention relates to a method for producing a peptide, characterized in that the peptide is solid-phase-synthesized while stirring with a centrifugal stirrer equipped with no impeller.
C07K 1/04 - General processes for the preparation of peptides on carriers
B01F 7/16 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a vertical axis
B01F 7/32 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a vertical axis with openwork frames or cages
C07K 1/34 - ExtractionSeparationPurification by filtration, ultrafiltration or reverse osmosis
15.
Axially chiral N-(2-acylaryl)-2-[5,7-dihydro-6h-dibenzo[c,e]azepin-6-yl] acetamide compound and chirality interconversion method of a-amino acid using the same
An object of the present invention is to provide a method for producing an optically active amino acid in high yield and in a highly enantioselective manner, which method has fewer restrictions on the material that can be used as the substrate, and to provide, among others, a compound useful as a chiral auxiliary for the method. The present invention provides an N-(2-acylaryl)-2-[5,7-dihydro-6H-dibenzo[c,e]azepin-6-yl]acetamide compound represented by Formula (1):
or a salt thereof, or a metal complex represented, by Formula (3):
C07D 223/14 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
C07C 319/12 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
C07D 209/20 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
C07C 227/32 - Preparation of optical isomers by stereospecific synthesis
C07C 229/08 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
METHOD FOR SYNTHESIZING OPTICALLY ACTIVE α-AMINO ACID USING CHIRAL METAL COMPLEX COMPRISING AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL]ACETAMIDE COMPOUND AND AMINO ACID
The purpose of the invention is to provide a production method that makes possible the industrial production of an optically active α-amino acid at high yield and high enantioselectivity, to provide a simple method for producing optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful in the methods for producing the above optically active α-amino acid and α,α-disubstituted α-amino acid. Provided is a method for producing an optically active α-amino acid or salt thereof characterized in that a substituent is introduced at the α carbon of the α-amino acid moiety structure of a metal complex represented by formula (1) by an alkylation reaction, Aldol reaction, Michael reaction, or Mannich reaction, and an optically pure α-amino acid enantiomer or salt thereof is then liberated by decomposing the metal complex by an acid.
C07C 227/32 - Preparation of optical isomers by stereospecific synthesis
C07C 229/24 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
C07C 229/30 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
C07C 229/48 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
C07C 231/18 - Preparation of optical isomers by stereospecific synthesis
C07C 237/06 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
C07C 323/58 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
C07D 223/14 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
A method is provided for producing optically active alcohols from ketones by reducing a ketone in the presence of an iridium(III) complex having a chiral prolinamide compound as a ligand. The ketone is preferably a compound represented by formula [I]:
2 may be bound to each other at any appropriate position to form a ring, the ring optionally containing one or more atoms which may be the same or different and are selected from an oxygen atom, an optionally substituted nitrogen atom and a sulfur atom, and optionally being condensed with an aromatic or hetero-aromatic ring).
C07D 207/09 - Radicals substituted by nitrogen atoms not forming part of a nitro radical
C07C 29/143 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of ketones
C07D 311/74 - Benzo [b] pyrans, hydrogenated in the carbocyclic ring
C07C 41/26 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process. The disclosed method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines comprises reducing a quinoline compound represented by formula [I]:
in the presence of a hydrogen donor compound and an iridium (III) complex having a chiral prolinamide compound as a ligand to give an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II]:
C07D 215/00 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
C07D 215/04 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
C07D 215/06 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
C07D 215/22 - Oxygen atoms attached in position 2 or 4
C07D 215/227 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
C07D 215/14 - Radicals substituted by oxygen atoms
19.
AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[C,E]AZEPIN-6-YL]ACETAMIDE COMPOUND AND CHIRALITY INTERCONVERSION METHOD OF .ALPHA.-AMINO ACID USING THE SAME
An object of the present invention is to provide a method for producing an optically active amino acid in high yield and in a highly enantioselective manner, which method has fewer restrictions on the material that can be used as the substrate, and to provide, among others, a compound useful as a chiral auxiliary for the method. The present invention provides an N-(2-acylaryl)-2-[5,7-dihydro-6H-dibenzo[c,e]azepin-6-yl]acetamide compound represented by Formula (1):(See Formula 1)or a salt thereof, or a metal complex represented by Formula (3):(See Formula 3)
C07C 227/32 - Preparation of optical isomers by stereospecific synthesis
C07C 229/08 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
C07D 223/14 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
AXIAL-ASYMMETRIC N-(2-ACYLARYL)-2-[5, 7-DIHYDRO-6H-DIBENZO [C, E] AZEPINE-6-YL] ACETAMIDE COMPOUND AND CHIRALITY CONVERSION METHOD FOR Α-AMINO ACID USING SAME
The present invention addresses the problem of providing: a production method capable of high-yield/high-enantioselectively producing an optically active amino acid having few restrictions on the material that can be used as the substrate therefor; and a useful compound, as a chiral auxiliary agent; etc. The present invention provides an N-(2-acylaryl)-2-[5, 7-dihydro-6H-dibenzo [c, e] azepine-6-yl] acetamide compound indicated in formula (1), a salt thereof, or a metal complex indicated in formula (3).
C07D 223/14 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
C07C 227/32 - Preparation of optical isomers by stereospecific synthesis
C07C 229/08 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Provided is a method for producing an optically active alcohol with high yield by an industrially advantageous process with use of a low-cost asymmetric catalyst, while using a ketone, which may have various structures, as a starting material. A method for producing an optically active alcohol of the present invention is characterized by reducing a ketone in the presence of an iridium (III) complex that has a chiral proline amide compound as a ligand. It is preferable that the ketone is a compound represented by formula [I]. (In the formula, R1 and R2 are different from each other and represent an optionally substituted linear or branched alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group, an optionally substituted heteroaryl alkyl group, an optionally substituted alkenyl group or an optionally substituted alkynyl group; the R1 and R2 may combine together at arbitrary positions to form ring(s); and the rings may be the same or different and contain one or more oxygen atoms, an optionally substituted nitrogen atom or a sulfur atom, and may be fused with an aromatic ring or a heterocyclic aromatic ring.)
C07C 29/143 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of ketones
C07C 35/17 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing six-membered rings with unsaturation only outside the ring
C07C 35/22 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
C07C 41/26 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
C07C 43/196 - Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
C07D 311/74 - Benzo [b] pyrans, hydrogenated in the carbocyclic ring
Provided are: a novel iridium (III) complex that is chiral; and a production method wherein a 2-substituted-quinoline is converted into an optically active 2-substituted-1,2,3,4-tetrahydroquinoline with use of a chiral iridium (III) complex by economical and easily operable processes. A method for producing an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II], which is characterized by reducing a quinoline compound represented by formula [I] in the presence of a hydrogen-donating compound and an iridium (III) complex that has a chiral proline amide compound as a ligand.
C07D 215/04 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
A method for producing a fine powder of loxoprofen sodium dihydrate for pharmaceutical preparations, said method comprising milling loxoprofen sodium dihydrate crystals or a crystalline powder of loxoprofen sodium dihydrate with an impact mill, preferably a pulverizer-type mill, which is provided with a built-in air-classifying system and comprises a pin hammer, to thereby continuously produce a fine powder of loxoprofen sodium dihydrate the volume-average particle size of which is in the range of 20-120 μm, when measured with a laser diffraction particle size analyzer.
Disclosed are: a prophylactic or therapeutic agent for hyperlipemia, which contains a carnosinase inhibitor and L-carnosines; and an anti-fatigue agent which contains a carnosinase inhibitor and L-carnosines. The free fatty acid concentration in the plasma of a mammal can be decreased by the combined use of a carnosinase inhibitor and L-carnosines. In addition, the lactic acid concentration in the plasma can be decreased by the combined use of a carnosinase inhibitor and L-carnosines, thereby reducing fatigue, enhancing recovery from fatigue and improving endurance. Preferable examples of the carnosinase inhibitor may include β-alanine, N-alkanoyl-β-alanine derivatives, N-alkanoyl-L-carnosine derivatives and the like, and preferable examples of the L-carnosines may include L-carnosine, N-acetyl-L-carnosine, L-anserine, N-acetyl-L-anserine, L-balenine, L-homocarnosine, N-acetyl-L-homocarnosine, carcinine and the like.
A61K 31/4172 - Imidazole-alkanecarboxylic acids, e.g. histidine
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 9/00 - Drugs for disorders of the cardiovascular system
A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
The present invention provides a method for producing chiral amines, comprising asymmetric transfer hydrogenation of imine compounds in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand. The present invention is useful for production of chiral amines in an efficient manner in terms of their optical and chemical yields.
A compound represented by general formula (1), a tautomer thereof, or a salt of the compound or tautomer, which is useful as a bactericide/disinfectant. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like, R2 represents a hydrogen atom or an optionally substituted alkyl group, or alternatively R1 and R2 may combine together with an adjacent nitrogen atom to form an optionally substituted nitrogen-containing heterocyclic group; R4 represents a hydrogen atom or an optionally substituted alkyl group; R3 represents an optionally substituted alkyl group; and R5 and R6 each represents a hydrogen atom or a methyl group. In this connection, a compound wherein both R2 and R4 represent a hydrogen atom and a compound wherein both R1 and R4 represent a hydrogen atom are excluded.)
C07D 251/10 - Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
Disclosed is a process for producing 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, which is a compound useful as a pharmaceutical agent, with high efficiency and in an industrially advantageous manner. Specifically disclosed is a process for producing 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, which is represented by scheme (I). [In the scheme, R1 and R2 independently represent a protective group for a hydroxy group, or R1 and R2 together form a protective group for a hydroxy group; R3 and R4 independently represent a protective group for a hydroxy group; R5 represents a protective group for a hydroxy group; R6 represents a protective group for a hydroxy group; X represents a leaving group; and Y represents a halogen atom.]
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
Disclosed is a method for purifying 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof, which is characterized in that a crystal of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof is deposited by bringing a solution containing a base salt of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine and a base salt of a diastereomer of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine into contact with a solvent in which base salts of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine are poorly soluble. The method can efficiently and commercially advantageously purify 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof, which is useful as a pharmaceutical product.
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
Disclosed is a method for producing a chiral amine, which is characterized in that an imine compound is subjected to a hydrogen transfer-type asymmetric reduction in the presence of an iridium (III) complex having a chiral proline amide compound as a ligand and a hydrogen-donating compound. This method is useful for producing a chiral amine efficiently in both optical yield and chemical yield.
C07C 213/02 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
C07C 217/70 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
C07C 303/40 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
C07C 311/37 - Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
