Abrégé

The continuous liquid separation is a continuous liquid separating apparatus that separates a first liquid and a second liquid that is immiscible to the first liquid and has a higher specific gravity than the first liquid, and includes: a liquid separating tank configured to contain a liquid, and be supplied with a liquid mixture of the first liquid and the second liquid, and including a first discharge portion on a lower side thereof and a second discharge portion disposed at a position higher than the first discharge portion, a valve configured to open/close the first discharge portion, a first sensor configured to detect a first water level of the liquid mixture contained in the liquid separating tank, the first water level being lower than the second discharge portion, and a second sensor configured to detect a second water level of the liquid mixture contained in the liquid separating tank.

Classes IPC  ?

• B01D 17/02 - Séparation de liquides non miscibles
• B01D 17/12 - Dispositifs auxiliaires spécialement adaptés pour être utilisés avec les appareils pour séparer des liquides, p. ex. circuits de commande
• G01F 23/292 - Lumière

Produits et services

Chemicals; industrial chemicals; chemicals used in science; plant extracts for use in the manufacture of pharmaceuticals; plant extracts for use in the manufacture of cosmetics; plant extracts for use in the manufacture of food; chemical additives for use in the manufacture of food; animal extracts for use in manufacture of pharmaceuticals; animal extracts for use in manufacture of cosmetics; animal extracts for use in the manufacture of foods; glues and adhesives for industrial purposes; plant growth regulating preparations; chemicals used in agriculture, horticulture and forestry; fertilizers; ceramic glazings; oil cement [putty]; higher fatty acids; fatty acids for industrial purpose; non-metallic minerals; non-metallic minerals for use in manufacture; photographic chemicals; photographic developers; reagent paper [not for medical purposes]; reagent paper, other than for medical or veterinary purposes; artificial sweeteners; artificial sweeteners [chemical preparations]; flour and starch for industrial purposes; plastics [raw materials]; plastics, unprocessed; paper pulp, cellulose pulp, wood pulp; paper pulp; dissolving pulp. Anti-static preparations for household purposes; de-greasing preparations for household purposes; rust removing preparations; stain removing benzine; fabric softeners for laundry use; laundry bleach; adhesives for affixing false hair; laundry starch; seaweed gelatine for laundry use [Funori]; adhesives for affixing false eyelashes; breath freshening preparations; breath freshening preparations for personal hygiene; deodorants for animals; paint stripping preparations; shoe cream; shoe black [shoe polish]; polishing preparations; soaps and detergents; bar soap; bath soaps; liquid soap; detergent soap; detergents for household use; dentifrices; cosmetics; perfumes and fragrances; perfumes; perfumes for industrial purposes; essential oils for use as food and drink flavorings; essential oils; body deodorant cosmetics and fragrances; fragrances; incense; abrasive paper; abrasive cloth; abrasive sand; artificial pumice stone; polishing paper; false nails; false eyelashes. Pharmaceutical preparations and other preparations for destroying vermin, fungicides, herbicides; pharmaceutical preparations; pharmaceutical, medical and veterinary preparations; chemical reagents for medical or veterinary purposes; vitamin preparations; nutritional additives; disinfectants; preparations for destroying vermin; fungicides; herbicides; plant extracts for pharmaceutical purposes; nutritional supplement drinks; nursing tonic nutritional supplement drinks; nutritional supplement beverage; reagent paper for medical purposes; oiled paper for medical purposes; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; gauze for dressings; empty capsules for pharmaceuticals; eyepatches for medical purposes; ear bandages; menstruation bandages; menstruation tampons; sanitary napkins; sanitary panties; absorbent cotton; adhesive plasters; bandages for dressings; liquid bandages; liquid bandages for skin wounds; breast-nursing pads; cotton swabs for medical use; dental materials; diapers; diaper covers; mothproofing paper; lacteal flour for babies; dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; dietetic substances for medical use; dietetic substances adapted for medical use; dietetic food and substances adapted for medical or veterinary use; dietetic food and substances adapted for medical or veterinary use, food for babies; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary foods supplements for pets; dietary foods supplements for livestock feed; dietary foods supplements for wild animals; dietary foods supplements for sea animals; dietary foods supplements for fish; semen for artificial insemination; propolis dietary supplements. Binding agents for ice cream; meat tenderizers for household purposes; preparations for stiffening whipped cream; aromatic preparations for food, not from essential oils; aromatic preparations for food; aromatic preparations being flavourings for drinks, not from essential oils; aromatic preparations being flavourings for drinks; tea; prepared coffee and coffee-based beverages; coffee; coffee-based beverages; coffee substitutes; prepared cocoa and cocoa-based beverages; cocoa; cocoa-based beverages; confectionery other than fruit-based, vegetable-based, bean-based or nut-based; chocolate desserts, muesli desserts, custard-based desserts, ice cream desserts; cereal-based, chocolate-based and rice-based snacks; confectionery; bread and buns; sandwiches; steamed buns stuffed with minced meat [Chuka-manjuh]; hamburgers [sandwiches]; hamburger sandwiches; pizzas; hot dogs [sandwiches]; hot dogs sandwiches; meat pies; seasonings [other than spices]; seasonings; sauces [condiments]; miso; worcester sauce; meat gravies; ketchup; tomato ketchup; ketchup (sauce); soy sauce [soya sauce]; soy sauce; soya sauce; vinegar; vinegar mixes; vinegar base; seasoning soy sauce [Sobatsuyu]; salad dressings; white sauce; bechamel [white sauce]; mayonnaise; sauces for barbecued meat; barbecue sauce; cube sugar; fructose for culinary purposes; crystal sugar [not confectionery]; sugar; maltose for culinary purposes; maltose; honey; glucose for culinary purposes; powdered starch syrup for culinary purposes; powdered candy; starch syrup for culinary purposes; table salt mixed with sesame seeds; cooking salt; roasted and ground sesame seeds; celery salt; umami seasonings; spices; ice cream mixes; sherbet mixes [ices]; cereal preparations; chocolate spread; chocolate-based spreads; yeast powder; Koji [fermented malted rice]; yeast; baking powder; instant confectionery mixes; pasta sauce; by-product of rice for food [Sake lees]; husked rice; husked oats; husked barley; gluten for food; gluten prepared as foodstuff; flour; propolis; royal jelly. Food processing; processing of foodstuffs for use in manufacture; plant extraction being services of biological materials treatment; animal extraction being services of biological materials treatment; fruit crushing; processing of raw materials for the manufacture of functional foods; custom manufacture of dietary supplements; custom manufacture of dietary supplements for human beings; processing of raw materials for the manufacture of food and beverages; processing of raw materials for the manufacture of cosmetics; processing of chemicals; processing of raw materials for the manufacture of pharmaceuticals; custom manufacture of pharmaceuticals; custom manufacture of products for the pharmaceutical, chemical and food industries by compressing and compacting powders and granules; processing of artificial limbs or artificial teeth, including processing of medical materials; water treating; recycling of waste; rental of machines and apparatus for processing foods or beverages; rental of water purifying apparatus; rental of chemical processing machines and apparatus; providing material treatment information; custom manufacture of pharmaceutical raw materials; custom manufacture of drug substance; custom manufacture of pharmaceutical intermediate; custom manufacture of pharmaceutical additives; custom manufacture of pharmaceutical ingredients; custom manufacture of chemicals; custom manufacture of cosmetics; custom manufacture of cosmetic ingredients; custom processing of foods, other than cooking; custom processing of ingredients for food industry; custom manufacture of medical materials; custom manufacture of amino acids; custom manufacture of active pharmaceutical ingredients; custom manufacture of biopharmaceuticals. Providing meteorological information; architectural design; surveying; geological surveys or research; geological surveys; geological research; designing of machines, apparatus, instruments [including their parts] or systems composed of such machines, apparatus and instruments; designing, other than for advertising purposes; computer software design, computer programming, or maintenance of computer software; computer software design; computer programming; maintenance of computer software; technological advice relating to computers, automobiles and industrial machines; testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; pharmaceutical research service; pharmaceutical research; medical research; testing, inspection or research of pharmaceutical raw materials; research of pharmaceutical production methods; testing, inspection or research of drug substance; research of drug substance production methods; testing, inspection or research of pharmaceutical intermediate; research of pharmaceutical intermediate production method; testing, inspection or research of pharmaceutical additives; research of pharmaceutical additive production methods; testing, inspection or research of pharmaceutical ingredients; research of pharmaceutical ingredient production methods; testing, inspection or research of chemicals; chemical analysis; chemical research; research of chemical production methods; development and test of chemical production methods; testing, inspection or research of cosmetics; research of cosmetic production methods; laboratory research in the field of cosmetics; laboratory analysis in the field of cosmetics; testing, inspection or research of cosmetic ingredients; research of cosmetic ingredient production methods; testing, inspection or research of foodstuffs; food research; research on food; research in the field of food; research of foodstuff production methods; testing, inspection or research of foodstuff ingredients; research of foodstuff ingredient production methods; testing, inspection or research of medical materials; research of medical material production methods; testing, inspection or research in the field of pharmaceutical, chemical and food industries; research of production methods in the field of pharmaceutical, chemical and food industries; testing, inspection and research services in the fields of pharmaceuticals, cosmetics and foodstuffs; research on building construction or city planning; testing or research on prevention of pollution; testing or research on electricity; testing or research on civil engineering; testing, inspection or research of agriculture, livestock breeding or fisheries; testing or research on machines, apparatus and instruments; rental of measuring apparatus; rental of computers; providing computer programs on data networks; rental of laboratory apparatus and instruments; rental of technical drawing instruments; design and development of new technology for others; scientific research and development; scientific and medical research and development; provision of information and data relating to scientific and technological research and development; research and development of new products for others; product development for others.

Produits et services

Chemicals; industrial chemicals; chemicals used in science; plant extracts for use in the manufacture of pharmaceuticals; plant extracts for use in the manufacture of cosmetics; plant extracts for use in the manufacture of food; chemical additives for use in the manufacture of food; animal extracts for use in manufacture of pharmaceuticals; animal extracts for use in manufacture of cosmetics; animal extracts for use in the manufacture of foods; glues and adhesives for industrial purposes; plant growth regulating preparations; chemicals used in agriculture, horticulture and forestry; fertilizers; ceramic glazings; oil cement [putty]; higher fatty acids; fatty acids for industrial purpose; non-metallic minerals; non-metallic minerals for use in manufacture; photographic chemicals; photographic developers; reagent paper [not for medical purposes]; reagent paper, other than for medical or veterinary purposes; artificial sweeteners; artificial sweeteners [chemical preparations]; flour and starch for industrial purposes; plastics [raw materials]; plastics, unprocessed; paper pulp, cellulose pulp, wood pulp; paper pulp; dissolving pulp. Anti-static preparations for household purposes; de-greasing preparations for household purposes; rust removing preparations; stain removing benzine; fabric softeners for laundry use; laundry bleach; adhesives for affixing false hair; laundry starch; seaweed gelatine for laundry use [Funori]; adhesives for affixing false eyelashes; breath freshening preparations; breath freshening preparations for personal hygiene; deodorants for animals; paint stripping preparations; shoe cream; shoe black [shoe polish]; polishing preparations; soaps and detergents; bar soap; bath soaps; liquid soap; detergent soap; detergents for household use; dentifrices; cosmetics; perfumes and fragrances; perfumes; perfumes for industrial purposes; essential oils for use as food and drink flavorings; essential oils; body deodorant cosmetics and fragrances; fragrances; incense; abrasive paper; abrasive cloth; abrasive sand; artificial pumice stone; polishing paper; false nails; false eyelashes. Pharmaceutical preparations and other preparations for destroying vermin, fungicides, herbicides; pharmaceutical preparations; pharmaceutical, medical and veterinary preparations; chemical reagents for medical or veterinary purposes; vitamin preparations; nutritional additives; disinfectants; preparations for destroying vermin; fungicides; herbicides; plant extracts for pharmaceutical purposes; nutritional supplement drinks; nursing tonic nutritional supplement drinks; nutritional supplement beverage; reagent paper for medical purposes; oiled paper for medical purposes; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; gauze for dressings; empty capsules for pharmaceuticals; eyepatches for medical purposes; ear bandages; menstruation bandages; menstruation tampons; sanitary napkins; sanitary panties; absorbent cotton; adhesive plasters; bandages for dressings; liquid bandages; liquid bandages for skin wounds; breast-nursing pads; cotton swabs for medical use; dental materials; diapers; diaper covers; mothproofing paper; lacteal flour for babies; dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; dietetic substances for medical use; dietetic substances adapted for medical use; dietetic food and substances adapted for medical or veterinary use; dietetic food and substances adapted for medical or veterinary use, food for babies; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary foods supplements for pets; dietary foods supplements for livestock feed; dietary foods supplements for wild animals; dietary foods supplements for sea animals; dietary foods supplements for fish; semen for artificial insemination; propolis dietary supplements. Binding agents for ice cream; meat tenderizers for household purposes; preparations for stiffening whipped cream; aromatic preparations for food, not from essential oils; aromatic preparations for food; aromatic preparations being flavourings for drinks, not from essential oils; aromatic preparations being flavourings for drinks; tea; prepared coffee and coffee-based beverages; coffee; coffee-based beverages; coffee substitutes; prepared cocoa and cocoa-based beverages; cocoa; cocoa-based beverages; confectionery other than fruit-based, vegetable-based, bean-based or nut-based; chocolate desserts, muesli desserts, custard-based desserts, ice cream desserts; cereal-based, chocolate-based and rice-based snacks; confectionery; bread and buns; sandwiches; steamed buns stuffed with minced meat [Chuka-manjuh]; hamburgers [sandwiches]; hamburger sandwiches; pizzas; hot dogs [sandwiches]; hot dogs sandwiches; meat pies; seasonings [other than spices]; seasonings; sauces [condiments]; miso; worcester sauce; meat gravies; ketchup; tomato ketchup; ketchup (sauce); soy sauce [soya sauce]; soy sauce; soya sauce; vinegar; vinegar mixes; vinegar base; seasoning soy sauce [Sobatsuyu]; salad dressings; white sauce; bechamel [white sauce]; mayonnaise; sauces for barbecued meat; barbecue sauce; cube sugar; fructose for culinary purposes; crystal sugar [not confectionery]; sugar; maltose for culinary purposes; maltose; honey; glucose for culinary purposes; powdered starch syrup for culinary purposes; powdered candy; starch syrup for culinary purposes; table salt mixed with sesame seeds; cooking salt; roasted and ground sesame seeds; celery salt; umami seasonings; spices; ice cream mixes; sherbet mixes [ices]; cereal preparations; chocolate spread; chocolate-based spreads; yeast powder; Koji [fermented malted rice]; yeast; baking powder; instant confectionery mixes; pasta sauce; by-product of rice for food [Sake lees]; husked rice; husked oats; husked barley; gluten for food; gluten prepared as foodstuff; flour; propolis; royal jelly. Food processing; processing of foodstuffs for use in manufacture; plant extraction being services of biological materials treatment; animal extraction being services of biological materials treatment; fruit crushing; processing of raw materials for the manufacture of functional foods; custom manufacture of dietary supplements; custom manufacture of dietary supplements for human beings; processing of raw materials for the manufacture of food and beverages; processing of raw materials for the manufacture of cosmetics; processing of chemicals; processing of raw materials for the manufacture of pharmaceuticals; custom manufacture of pharmaceuticals; custom manufacture of products for the pharmaceutical, chemical and food industries by compressing and compacting powders and granules; processing of artificial limbs or artificial teeth, including processing of medical materials; water treating; recycling of waste; rental of machines and apparatus for processing foods or beverages; rental of water purifying apparatus; rental of chemical processing machines and apparatus; providing material treatment information; custom manufacture of pharmaceutical raw materials; custom manufacture of drug substance; custom manufacture of pharmaceutical intermediate; custom manufacture of pharmaceutical additives; custom manufacture of pharmaceutical ingredients; custom manufacture of chemicals; custom manufacture of cosmetics; custom manufacture of cosmetic ingredients; custom processing of foods, other than cooking; custom processing of ingredients for food industry; custom manufacture of medical materials; custom manufacture of amino acids; custom manufacture of active pharmaceutical ingredients; custom manufacture of biopharmaceuticals. Providing meteorological information; architectural design; surveying; geological surveys or research; geological surveys; geological research; designing of machines, apparatus, instruments [including their parts] or systems composed of such machines, apparatus and instruments; designing, other than for advertising purposes; computer software design, computer programming, or maintenance of computer software; computer software design; computer programming; maintenance of computer software; technological advice relating to computers, automobiles and industrial machines; testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; pharmaceutical research service; pharmaceutical research; medical research; testing, inspection or research of pharmaceutical raw materials; research of pharmaceutical production methods; testing, inspection or research of drug substance; research of drug substance production methods; testing, inspection or research of pharmaceutical intermediate; research of pharmaceutical intermediate production method; testing, inspection or research of pharmaceutical additives; research of pharmaceutical additive production methods; testing, inspection or research of pharmaceutical ingredients; research of pharmaceutical ingredient production methods; testing, inspection or research of chemicals; chemical analysis; chemical research; research of chemical production methods; development and test of chemical production methods; testing, inspection or research of cosmetics; research of cosmetic production methods; laboratory research in the field of cosmetics; laboratory analysis in the field of cosmetics; testing, inspection or research of cosmetic ingredients; research of cosmetic ingredient production methods; testing, inspection or research of foodstuffs; food research; research on food; research in the field of food; research of foodstuff production methods; testing, inspection or research of foodstuff ingredients; research of foodstuff ingredient production methods; testing, inspection or research of medical materials; research of medical material production methods; testing, inspection or research in the field of pharmaceutical, chemical and food industries; research of production methods in the field of pharmaceutical, chemical and food industries; testing, inspection and research services in the fields of pharmaceuticals, cosmetics and foodstuffs; research on building construction or city planning; testing or research on prevention of pollution; testing or research on electricity; testing or research on civil engineering; testing, inspection or research of agriculture, livestock breeding or fisheries; testing or research on machines, apparatus and instruments; rental of measuring apparatus; rental of computers; providing computer programs on data networks; rental of laboratory apparatus and instruments; rental of technical drawing instruments; design and development of new technology for others; scientific research and development; scientific and medical research and development; provision of information and data relating to scientific and technological research and development; research and development of new products for others; product development for others.

Produits et services

Chemicals; industrial chemicals. Dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietary supplements consisting of minerals; dietetic beverages adapted for medical purposes; dietetic food adapted for medical purposes; dietetic substances for medical use other than pharmaceutical preparations; dietetic substances adapted for medical use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use, food for babies other than pharmaceutical preparations; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary food supplements for pets; dietary food supplements for livestock feed; dietary foods supplements for wild animals; dietary food supplements for sea animals; dietary foods supplements for fish.

Produits et services

Chemicals; industrial chemicals; chemical used in science; glue and adhesives for industrial purposes; plant growth regulating preparations; chemical used in agriculture, horticulture and forestry; fertilizers; ceramic glazings; oil cement [putty]; higher fatty acids; fatty acids for industrial purpose; non-metallic minerals; non-metallic minerals for use in manufacture; photographic chemicals; reagent paper [not for medical purposes]; reagent paper, other than for medical or veterinary purposes; artificial sweeteners; flour and starch for industrial purposes; plastics [raw materials]; plastic, unprocessed; pulp; paper pulp; dissolving pulp. Custom manufacture of pharmaceuticals; custom manufacture of products for the pharmaceutical, chemical and food industries by compressing and compacting powders and granules; custom manufacture of pharmaceutical raw materials; custom manufacture of drug substance; custom manufacture of pharmaceutical intermediate; custom manufacture of pharmaceutical additives; custom manufacture of pharmaceutical ingredients; custom manufacture of chemicals; custom manufacture of cosmetics; custom manufacture of cosmetic ingredients; custom manufacture of foods; custom manufacture of food ingredients; custom manufacture of medical materials; custom manufacture of amino acids; custom manufacture of active pharmaceutical ingredients; custom manufacture of biopharmaceuticals. Testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; pharmaceutical research services; pharmaceutical research; medical research; testing, inspection or research of pharmaceutical raw materials; research of pharmaceutical production methods; testing, inspection or research of drug substance; research of drug substance production methods; testing, inspection or research of pharmaceutical intermediate; research of pharmaceutical intermediate production method; testing, inspection or research of pharmaceutical additives; research of pharmaceutical additive production methods; testing, inspection or research of pharmaceutical ingredients; research of pharmaceutical ingredient production methods; testing, inspection or research of chemicals; chemical analysis; chemical research; research of chemical production methods; development and test of chemical production methods; testing, inspection or research of cosmetics; research of cosmetic production methods; laboratory research in the field of cosmetics; laboratory analysis in the field of cosmetics; testing, inspection or research of cosmetic ingredients; research of cosmetic ingredient production methods; testing, inspection or research of foodstuffs; food research; research on food; research in the field of food; research of foodstuff production methods; testing, inspection or research of foodstuff ingredients; research of foodstuff ingredient production methods; testing, inspection or research of medical materials; research of medical material production methods; testing, inspection or research of pharmaceutical products and foods and drinks; research on manufacturing methods for pharmaceutical products and foods and drinks; testing, inspection or research on agriculture, livestock breeding or fisheries; design and development of new technology for others; scientific research and development; scientific and medical research and development; provision of information and data relating to scientific and technological research and development; research and development of new products for others; product development for others.

Produits et services

Chemicals; industrial chemicals. Dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietary supplements consisting of minerals; dietetic beverages adapted for medical purposes; dietetic food adapted for medical purposes; dietetic substances for medical use other than pharmaceutical preparations; dietetic substances adapted for medical use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary, food for babies other than pharmaceutical preparations; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary food supplements for pets; dietary food supplements for livestock feed; dietary foods supplements for wild animals; dietary food supplements for sea animals; dietary foods supplements for fish.

Produits et services

Industrial chemicals

Produits et services

Industrial chemicals

Produits et services

(1) Chemicals; industrial chemicals. (2) Dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietary supplements consisting of minerals; dietetic beverages adapted for medical purposes; dietetic food adapted for medical purposes; dietetic substances for medical use other than pharmaceutical preparations; dietetic substances adapted for medical use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary, food for babies other than pharmaceutical preparations; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary food supplements for pets; dietary food supplements for livestock feed; dietary foods supplements for wild animals; dietary food supplements for sea animals; dietary foods supplements for fish.

Produits et services

Industrial chemicals Dietary food supplements

Produits et services

(1) Chemicals; industrial chemicals. (2) Dietary supplements for humans; dietary supplements for human consumption; dietary food supplements; dietary supplements consisting of minerals; dietetic beverages adapted for medical purposes; dietetic food adapted for medical purposes; dietetic substances for medical use other than pharmaceutical preparations; dietetic substances adapted for medical use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use other than pharmaceutical preparations; dietetic food and substances adapted for medical or veterinary use, food for babies other than pharmaceutical preparations; beverages for babies; food for babies; dietary supplements for animals; nutritional supplements for animals; dietary food supplements for pets; dietary food supplements for livestock feed; dietary foods supplements for wild animals; dietary food supplements for sea animals; dietary foods supplements for fish.

Produits et services

Industrial chemicals Dietary food supplements

Abrégé

An object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a large amount of a peptide. Another object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a high-purity long-chain peptide. Still another object of the present invention is to provide a novel solid phase peptide synthesis method causing fewer side reactions. The present invention relates to a method for producing a peptide, and the method comprises solid-phase synthesis of a peptide under stirring with a centrifugal stirrer having no impeller.

Classes IPC  ?

• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• B01J 8/10 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules mobiles mues par des agitateurs ou par des tambours rotatifs ou par des récipients tournants
• B01F 7/32 - Mélangeurs à agitateurs tournant dans des récipients fixes; Pétrins avec agitateurs tournant autour d'un axe vertical à cages ou cadres ajourés
• B01F 15/06 - Systèmes de chauffage ou de refroidissement
• C07K 1/34 - ExtractionSéparationPurification par filtration, ultrafiltration ou osmose inverse
• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés

Abrégé

The present invention addresses the problem of providing a novel peptide solid-phase synthesis method for synthesizing a peptide in a large quantity. The present invention also addresses the problem of providing a novel peptide solid-phase synthesis method for synthesizing a long-chain peptide having high purity. The present invention also addresses the problem of providing a novel peptide solid-phase synthesis method which causes few side reactions. The present invention relates to a method for producing a peptide, characterized in that the peptide is solid-phase-synthesized while stirring with a centrifugal stirrer equipped with no impeller.

Classes IPC  ?

• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• B01F 7/16 - Mélangeurs à agitateurs tournant dans des récipients fixes; Pétrins avec agitateurs tournant autour d'un axe vertical
• B01F 7/32 - Mélangeurs à agitateurs tournant dans des récipients fixes; Pétrins avec agitateurs tournant autour d'un axe vertical à cages ou cadres ajourés
• C07K 1/34 - ExtractionSéparationPurification par filtration, ultrafiltration ou osmose inverse

Abrégé

An object of the present invention is to provide a method for producing an optically active amino acid in high yield and in a highly enantioselective manner, which method has fewer restrictions on the material that can be used as the substrate, and to provide, among others, a compound useful as a chiral auxiliary for the method. The present invention provides an N-(2-acylaryl)-2-[5,7-dihydro-6H-dibenzo[c,e]azepin-6-yl]acetamide compound represented by Formula (1): or a salt thereof, or a metal complex represented, by Formula (3):

Classes IPC  ?

• C07D 223/14 - Composés hétérocycliques contenant des cycles à sept chaînons ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07D 223/18 - DibenzazépinesDibenzazépines hydrogénées
• C07C 227/30 - Préparation d'isomères optiques
• C07C 319/12 - Préparation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures de thiols par des réactions n'impliquant pas la formation de groupes mercapto
• C07D 209/20 - Radicaux substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile substitués en outre par des atomes d'azote, p. ex. tryptophane
• C07B 53/00 - Synthèses asymétriques
• C07C 227/32 - Préparation d'isomères optiques par synthèse stéréospécifique
• C07C 229/08 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes d'hydrogène
• C07C 229/36 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné contenant des cycles aromatiques à six chaînons avec au moins un groupe amino et un groupe carboxyle liés au même atome de carbone du squelette carboné
• C07F 15/04 - Composés du nickel

Abrégé

　The purpose of the invention is to provide a production method that makes possible the industrial production of an optically active α-amino acid at high yield and high enantioselectivity, to provide a simple method for producing optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful in the methods for producing the above optically active α-amino acid and α,α-disubstituted α-amino acid. Provided is a method for producing an optically active α-amino acid or salt thereof characterized in that a substituent is introduced at the α carbon of the α-amino acid moiety structure of a metal complex represented by formula (1) by an alkylation reaction, Aldol reaction, Michael reaction, or Mannich reaction, and an optically pure α-amino acid enantiomer or salt thereof is then liberated by decomposing the metal complex by an acid.

Classes IPC  ?

• C07F 15/04 - Composés du nickel
• C07C 227/32 - Préparation d'isomères optiques par synthèse stéréospécifique
• C07C 229/24 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant plus d'un groupe carboxyle lié au squelette carboné, p. ex. acide aspartique
• C07C 229/30 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et non saturé
• C07C 229/36 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné contenant des cycles aromatiques à six chaînons avec au moins un groupe amino et un groupe carboxyle liés au même atome de carbone du squelette carboné
• C07C 229/48 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino ou carboxyle liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du même squelette carboné avec des groupes amino et des groupes carboxyle liés à des atomes de carbone du même cycle non condensé
• C07C 231/18 - Préparation d'isomères optiques par synthèse stéréospécifique
• C07C 237/06 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant les atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant acyclique et saturé ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
• C07C 319/20 - Préparation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures de sulfures par des réactions n'impliquant pas la formation de groupes sulfure
• C07C 323/58 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des groupes carboxyle liés au même squelette carboné ayant les atomes de soufre des groupes thio liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant substitué de plus par des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso avec des groupes amino liés au squelette carboné
• C07D 213/55 - AcidesEsters
• C07D 223/14 - Composés hétérocycliques contenant des cycles à sept chaînons ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07B 53/00 - Synthèses asymétriques

Abrégé

A method is provided for producing optically active alcohols from ketones by reducing a ketone in the presence of an iridium(III) complex having a chiral prolinamide compound as a ligand. The ketone is preferably a compound represented by formula [I]: 2 may be bound to each other at any appropriate position to form a ring, the ring optionally containing one or more atoms which may be the same or different and are selected from an oxygen atom, an optionally substituted nitrogen atom and a sulfur atom, and optionally being condensed with an aromatic or hetero-aromatic ring).

Classes IPC  ?

• C07D 207/09 - Radicaux substitués par des atomes d'azote ne faisant pas partie d'un radical nitro
• C07C 29/143 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par réduction d'un groupe fonctionnel contenant de l'oxygène de groupes contenant C=O, p. ex. —COOH de cétones
• C07D 311/74 - Benzo [b] pyrannes, hydrogénés dans le carbocycle
• C07C 41/26 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction de groupes hydroxyle ou O-métal
• C07B 53/00 - Synthèses asymétriques

Abrégé

Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process. The disclosed method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines comprises reducing a quinoline compound represented by formula [I]: in the presence of a hydrogen donor compound and an iridium (III) complex having a chiral prolinamide compound as a ligand to give an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II]:

Classes IPC  ?

• C07D 215/00 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée
• C07F 5/00 - Composés contenant des éléments des groupes 3 ou 13 du tableau périodique
• C07D 215/04 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle
• C07B 53/00 - Synthèses asymétriques
• C07F 17/02 - Metallocènes de métaux des groupes 8, 9 ou 10 du tableau périodique
• C07D 215/06 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle comportant uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés à l'atome d'azote du cycle
• C07D 215/18 - Atomes d'halogènes ou radicaux nitro
• C07D 215/20 - Atomes d'oxygène
• C07D 215/22 - Atomes d'oxygène liés en position 2 ou 4
• C07D 215/227 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 2
• C07D 215/14 - Radicaux substitués par des atomes d'oxygène

Abrégé

An object of the present invention is to provide a method for producing an optically active amino acid in high yield and in a highly enantioselective manner, which method has fewer restrictions on the material that can be used as the substrate, and to provide, among others, a compound useful as a chiral auxiliary for the method. The present invention provides an N-(2-acylaryl)-2-[5,7-dihydro-6H-dibenzo[c,e]azepin-6-yl]acetamide compound represented by Formula (1):(See Formula 1)or a salt thereof, or a metal complex represented by Formula (3):(See Formula 3)

Classes IPC  ?

• C07B 53/00 - Synthèses asymétriques
• C07B 61/00 - Autres procédés généraux
• C07C 227/32 - Préparation d'isomères optiques par synthèse stéréospécifique
• C07C 229/08 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes d'hydrogène
• C07C 229/36 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné contenant des cycles aromatiques à six chaînons avec au moins un groupe amino et un groupe carboxyle liés au même atome de carbone du squelette carboné
• C07D 223/14 - Composés hétérocycliques contenant des cycles à sept chaînons ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07F 15/04 - Composés du nickel

Abrégé

The present invention addresses the problem of providing: a production method capable of high-yield/high-enantioselectively producing an optically active amino acid having few restrictions on the material that can be used as the substrate therefor; and a useful compound, as a chiral auxiliary agent; etc. The present invention provides an N-(2-acylaryl)-2-[5, 7-dihydro-6H-dibenzo [c, e] azepine-6-yl] acetamide compound indicated in formula (1), a salt thereof, or a metal complex indicated in formula (3).

Classes IPC  ?

• C07D 223/14 - Composés hétérocycliques contenant des cycles à sept chaînons ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07C 227/32 - Préparation d'isomères optiques par synthèse stéréospécifique
• C07C 229/08 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes d'hydrogène
• C07C 229/36 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné contenant des cycles aromatiques à six chaînons avec au moins un groupe amino et un groupe carboxyle liés au même atome de carbone du squelette carboné
• C07B 53/00 - Synthèses asymétriques
• C07B 61/00 - Autres procédés généraux
• C07F 15/04 - Composés du nickel

Abrégé

Provided is a method for producing an optically active alcohol with high yield by an industrially advantageous process with use of a low-cost asymmetric catalyst, while using a ketone, which may have various structures, as a starting material. A method for producing an optically active alcohol of the present invention is characterized by reducing a ketone in the presence of an iridium (III) complex that has a chiral proline amide compound as a ligand. It is preferable that the ketone is a compound represented by formula [I]. (In the formula, R1 and R2 are different from each other and represent an optionally substituted linear or branched alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group, an optionally substituted heteroaryl alkyl group, an optionally substituted alkenyl group or an optionally substituted alkynyl group; the R1 and R2 may combine together at arbitrary positions to form ring(s); and the rings may be the same or different and contain one or more oxygen atoms, an optionally substituted nitrogen atom or a sulfur atom, and may be fused with an aromatic ring or a heterocyclic aromatic ring.)

Classes IPC  ?

• C07C 29/143 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par réduction d'un groupe fonctionnel contenant de l'oxygène de groupes contenant C=O, p. ex. —COOH de cétones
• C07C 35/17 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons monocycliques contenant des cycles à six chaînons avec insaturation uniquement hors du cycle
• C07C 35/22 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons polycycliques, avec au moins un groupe hydroxyle lié à un système cyclique condensé
• C07C 41/26 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction de groupes hydroxyle ou O-métal
• C07C 43/196 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle autre que ceux d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal
• C07D 311/74 - Benzo [b] pyrannes, hydrogénés dans le carbocycle
• C07B 53/00 - Synthèses asymétriques
• C07B 61/00 - Autres procédés généraux

Abrégé

Provided are: a novel iridium (III) complex that is chiral; and a production method wherein a 2-substituted-quinoline is converted into an optically active 2-substituted-1,2,3,4-tetrahydroquinoline with use of a chiral iridium (III) complex by economical and easily operable processes. A method for producing an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II], which is characterized by reducing a quinoline compound represented by formula [I] in the presence of a hydrogen-donating compound and an iridium (III) complex that has a chiral proline amide compound as a ligand.

Classes IPC  ?

• C07D 215/04 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle
• B01J 31/22 - Complexes organiques
• C07B 53/00 - Synthèses asymétriques
• C07B 61/00 - Autres procédés généraux
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 du tableau périodique
• C07F 17/00 - Metallocènes

Abrégé

A method for producing a fine powder of loxoprofen sodium dihydrate for pharmaceutical preparations, said method comprising milling loxoprofen sodium dihydrate crystals or a crystalline powder of loxoprofen sodium dihydrate with an impact mill, preferably a pulverizer-type mill, which is provided with a built-in air-classifying system and comprises a pin hammer, to thereby continuously produce a fine powder of loxoprofen sodium dihydrate the volume-average particle size of which is in the range of 20-120 μm, when measured with a laser diffraction particle size analyzer.

Classes IPC  ?

• A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 9/20 - Pilules, pastilles ou comprimés
• B02C 13/22 - Désagrégation par appareils à batteurs rotatifs avec des pics s'engrenant mutuellement

Abrégé

Disclosed are: a prophylactic or therapeutic agent for hyperlipemia, which contains a carnosinase inhibitor and L-carnosines; and an anti-fatigue agent which contains a carnosinase inhibitor and L-carnosines. The free fatty acid concentration in the plasma of a mammal can be decreased by the combined use of a carnosinase inhibitor and L-carnosines. In addition, the lactic acid concentration in the plasma can be decreased by the combined use of a carnosinase inhibitor and L-carnosines, thereby reducing fatigue, enhancing recovery from fatigue and improving endurance. Preferable examples of the carnosinase inhibitor may include β-alanine, N-alkanoyl-β-alanine derivatives, N-alkanoyl-L-carnosine derivatives and the like, and preferable examples of the L-carnosines may include L-carnosine, N-acetyl-L-carnosine, L-anserine, N-acetyl-L-anserine, L-balenine, L-homocarnosine, N-acetyl-L-homocarnosine, carcinine and the like.

Classes IPC  ?

• A61K 31/4172 - Acides imidazole-alkanecarboxyliques, p. ex. histidine
• A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
• A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
• A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
• A61K 47/38 - CelluloseSes dérivés
• A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
• A61P 3/04 - AnorexigènesMédicaments de l'obésité
• A61P 3/06 - Antihyperlipémiants
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 9/04 - Agents inotropes, c.-à-d. stimulants de la contraction cardiaqueMédicaments pour le traitement de l'insuffisance cardiaque
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 9/12 - Antihypertenseurs
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

The present invention provides a method for producing chiral amines, comprising asymmetric transfer hydrogenation of imine compounds in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand. The present invention is useful for production of chiral amines in an efficient manner in terms of their optical and chemical yields.

Classes IPC  ?

• C07C 303/00 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides
• C07C 211/00 - Composés contenant des groupes amino liés à un squelette carboné

Abrégé

A compound represented by general formula (1), a tautomer thereof, or a salt of the compound or tautomer, which is useful as a bactericide/disinfectant. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like, R2 represents a hydrogen atom or an optionally substituted alkyl group, or alternatively R1 and R2 may combine together with an adjacent nitrogen atom to form an optionally substituted nitrogen-containing heterocyclic group; R4 represents a hydrogen atom or an optionally substituted alkyl group; R3 represents an optionally substituted alkyl group; and R5 and R6 each represents a hydrogen atom or a methyl group.  In this connection, a compound wherein both R2 and R4 represent a hydrogen atom and a compound wherein both R1 and R4 represent a hydrogen atom are excluded.)

Classes IPC  ?

• C07D 251/10 - Composés hétérocycliques contenant des cycles triazine-1, 3, 5 non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
• A61K 8/43 - Guanidines
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61K 31/155 - Amidines (), p. ex. guanidine (H2N-C(=NH)-NH2), isourée (HN=C(OH)NH2), isothiourée (HN=C(SH)-NH2)
• A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
• A61P 31/02 - Antiseptiques locaux
• A61P 31/04 - Agents antibactériens
• C07C 279/26 - X et Y étant des atomes d'azote, c.-à-d. biguanides

Abrégé

Disclosed is a process for producing 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, which is a compound useful as a pharmaceutical agent, with high efficiency and in an industrially advantageous manner. Specifically disclosed is a process for producing 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, which is represented by scheme (I). [In the scheme, R1 and R2 independently represent a protective group for a hydroxy group, or R1 and R2 together form a protective group for a hydroxy group; R3 and R4 independently represent a protective group for a hydroxy group; R5 represents a protective group for a hydroxy group; R6 represents a protective group for a hydroxy group; X represents a leaving group; and Y represents a halogen atom.]

Classes IPC  ?

• C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C07H 19/067 - Radicaux pyrimidine avec un ribosyle comme radical saccharide

Abrégé

Disclosed is a method for purifying 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof, which is characterized in that a crystal of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof is deposited by bringing a solution containing a base salt of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine and a base salt of a diastereomer of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine into contact with a solvent in which base salts of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine are poorly soluble. The method can efficiently and commercially advantageously purify 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof, which is useful as a pharmaceutical product.

Classes IPC  ?

• C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C07H 19/073 - Radicaux pyrimidine avec un désoxy-2 ribosyle comme radical saccharide

Abrégé

Disclosed is a method for producing a chiral amine, which is characterized in that an imine compound is subjected to a hydrogen transfer-type asymmetric reduction in the presence of an iridium (III) complex having a chiral proline amide compound as a ligand and a hydrogen-donating compound. This method is useful for producing a chiral amine efficiently in both optical yield and chemical yield.

Classes IPC  ?

• C07C 213/02 - Préparation de composés contenant des groupes amino et hydroxy, amino et hydroxy éthérifiés ou amino et hydroxy estérifiés liés au même squelette carboné par des réactions impliquant la formation de groupes amino à partir de composés contenant des groupes hydroxy ou des groupes hydroxy éthérifiés ou estérifiés
• C07C 217/70 - Composés contenant des groupes amino et hydroxy éthérifiés liés au même squelette carboné ayant des groupes hydroxy éthérifiés liés à des atomes de carbone d'au moins un cycle aromatique à six chaînons et des groupes amino liés à des atomes de carbone acycliques ou à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du même squelette carboné avec des groupes amino reliés au cycle aromatique à six chaînons ou au système cyclique condensé contenant ce cycle, par l'intermédiaire de chaînes carbonées qui sont substituées de plus par des atomes d'oxygène liés par des liaisons simples avec des atomes d'oxygène liés par des liaisons simples et des cycles aromatiques à six chaînons liés au même atome de carbone de la chaîne carbonée reliés par l'intermédiaire de chaînes carbonées ayant deux atomes de carbone entre les groupes amino et le cycle aromatique à six chaînons ou le système cyclique condensé contenant ce cycle
• C07C 303/40 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'amides d'acides sulfoniques par des réactions n'impliquant pas la formation de groupes sulfonamide
• C07C 311/37 - Sulfonamides, le squelette carboné de la partie acide étant substitué de plus par des atomes d'azote liés par des liaisons simples, ne faisant pas partie de groupes nitro ou nitroso ayant l'atome de soufre d'au moins un des groupes sulfonamide lié à un atome de carbone d'un cycle aromatique à six chaînons
• C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07B 53/00 - Synthèses asymétriques

Produits et services

Food supplements

Produits et services

Mineral food supplements, not for medical purposes

Produits et services

(1) Mineral food-supplements, not for medical purposes.