Abstract

The present application relates to the technical field of health-care foods and particularly relates to the use of tremella polysaccharides in preparing products for preventing and treating high-fat diet induced anxiety. It is found by researches in the present application that tremella polysaccharides can relieve the weight gaining of mice fed by high-fat diet, reduce the weights of the liver and fat, inhibit microglial cell activation and neuritis in the hippocampus, balance the intestinal flora, and have an excellent improvement effect on preventing and treating anxiety of mice caused by high-fat diet feeding. The present application verifies that tremella polysaccharides have the effect of preventing and treating high-fat diet induced anxiety and thus can be used to prepare products for preventing and treating high-fat diet induced anxiety. Therefore, as a nutritional intervention strategy for high-fat diet induced anxiety disorders, tremella polysaccharides are of great significance for assisting in preventing and relieving high-fat diet induced anxiety disorders.

IPC Classes  ?

• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A61P 25/22 - Anxiolytics
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates

Abstract

Embodiments of the present application are suitable for the technical field of ultrasonics, and provide a method and apparatus for generating a head ultrasound image, a terminal device, and a storage medium. The method comprises: in response to a start instruction, obtaining a head depth image of an individual to be checked, and on the basis of the head depth image, determining a plurality of sites to be checked; on the basis of a head feature value of each site to be checked, determining a first target site from among the plurality of sites to be checked; transmitting an ultrasonic signal to the first target site by means of a signal transmit unit, so as to generate a first head ultrasound image of the individual to be checked. According to the method provided in the embodiments of the present application, the terminal device can assist an ultrasonic operator in quickly and accurately finding a target site, thereby quickly obtaining a high-quality ultrasound image.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/14 - Echo-tomography
• A61B 8/06 - Measuring blood flow
• A61B 8/08 - Clinical applications
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

Provided are novel recombinant fusion proteins comprising asparaginase portion fused with an albumin-binding portion. The long-acting recombinant fusion proteins are able to deplete both asparagine and glutamine upon administration to a subject in need thereof, enabling these proteins to be used in the treatment of disease treatable by asparagine and/or glutamine depletion, such as gastric cancer, and food treatment.

IPC Classes  ?

• C12N 9/82 - Asparaginase
• C07K 19/00 - Hybrid peptides
• C07K 14/245 - Escherichia (G)
• C07K 14/27 - Erwinia (G)
• A61K 35/50 - PlacentaPlacental stem cellsAmniotic fluidAmnionAmniotic stem cells
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The present invention provides a method for storing digital data in proteins including: providing digital code that has been encoded from the digital data; assigning each of a plurality of amino acid residues with a specific binary sequence composed of at least three bits each selected from "0" or "1", where the plurality of amino acid residues is selected from at least eight different amino acid residues as data-bearing amino acid residues; translating the digital code into an amino acid sequence according to the specific binary sequence assigned to each of the amino acid residues; and synthesizing the one or more proteins each including a plurality of peptide segments, where each of the peptide segments includes no more than 30 amino acid residues and each of the proteins contains 100 to 2, 000 amino acid residues. The present invention also provides a method for retrieving digital data from the proteins.

IPC Classes  ?

• G16B 50/30 - Data warehousingComputing architectures

Abstract

The present application relates to the prevention and treatment of osteoarticular diseases, in particular osteoarthritis (OA), by inhibition of acetylcholinesterase (AChE). Specifically, this application provides a disease progression-modifying drug for the treatment of osteoarthritis, i.e., an acetylcholinesterase inhibitor, in particular a dimeric acetylcholinesterase inhibitor. The dimer targets both the enzymatic triad and non-enzymatic peripheral sites of acetylcholinesterase, thereby enhancing protection of articular cartilage and subchondral bone.

IPC Classes  ?

• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

The present disclosure relates to the technical field of artificial intelligence, and provides a head size measurement method and a 3D head grid generation method. According to the method, a face local area is determined by means of face feature points, a circular reference object is extracted from the face local area, and a head size of a target object is determined on the basis of the size of the circular reference object, thereby generating a 3D head grid. The accuracy is high.

IPC Classes  ?

• G06T 17/00 - 3D modelling for computer graphics

Abstract

A bionic finger (10), comprising: skin (100), an elastomer (200), a rigid supporting member (300) and a liquid delivery tube (400), wherein the skin (100) is provided with first liquid output holes (110); the elastomer (200) is wrapped and mounted in the skin (100), the elastomer (200) is provided with second liquid output holes (210), and the rigid supporting member (300) is wrapped and mounted in the skin (100); and a side portion of a first end (401) of the liquid delivery tube (400) is provided with third liquid output holes (410), the third liquid output holes (410), the second liquid output holes (210) and the first liquid output holes (110) are in communication with each other, and a second end (402) of the liquid delivery tube (400) extends to the outside of the skin (100). When the skin (100) of the bionic finger (10) comes into contact with a grabbed object, a liquid can flow from the second end (402) of the liquid delivery tube (400) located outside the skin (100) to the first end (401) of the liquid delivery tube (400) located inside the skin (100), and reaches a position between the skin (100) and the grabbed object sequentially through the third liquid output holes (410), the second liquid output holes (210) and the first liquid output holes (110), such that a friction coefficient between the bionic finger (10) and the grabbed object is changed, and thus a friction force between the bionic finger and the grabbed object is changed, thereby solving the technical problem of being unable to adjust the friction force with the bionic finger. Further provided are a fixture, and a manufacturing method for the bionic finger.

IPC Classes  ?

• B25J 15/00 - Gripping heads

Abstract

The present disclosure belongs to the technical fields of computers and defect detection. Provided are a defect detection method and a related device. The method comprises: obtaining an image to be processed; processing said image by means of a feature extraction module in a deep-learning defect detection model, wherein the feature extraction module comprises an intermediate feature layer, the intermediate feature layer comprises a dropout layer, and the dropout layer is configured to randomly drop features which are extracted by means of the intermediate feature layer processing said image, such that a plurality of features subjected to random dropout are obtained after said image is processed by means of the feature extraction module; by means of a detection head in the deep-learning defect detection model, processing the plurality of features subjected to random dropout, so as to obtain a plurality of category prediction results and a plurality of position prediction results of defects in said image; and obtaining category detection results, position detection results, category uncertainties and position uncertainties of the defects in said image according to the plurality of category prediction results and the plurality of position prediction results of the defects. (FIG. 1)

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

A method for certifying a Science, Technology, Engineering and Mathematics (STEM) industrial product is provided. Exemplarily, the method comprises: evaluating and scoring (831) a STEM literacy level acquirable by using the product to thereby yield a first score for STEM literacy; evaluating and scoring (832) product features findable in the product to thereby yield a second score for product features; evaluating and scoring (833) general abilities learnable after using the product to thereby yield a third score for general abilities; making (842) a final decision on a total score for the product according to the first, second and third scores; and awarding (843) the product with a certification level according to the total score of the product.

IPC Classes  ?

• G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]

Abstract

A transcranial sonography application device (100), comprising an annular guide rail (12), a first mounting frame (21), a first object-bearing platform (22) and a first detection assembly (3). The annular guide rail (12) is erected on the head of a user, the first mounting frame (21) is slidably connected to the annular guide rail (12) and is configured to drive the first object-bearing platform (22) to rotate around a circumferential direction of the head of the user, and the first detection assembly (3) is disposed on the first object-bearing platform (22) and is configured to scan the outer contour of the head of the user and determine the position of a cranial acoustic window. The transcranial sonography application device (100) can solve the technical problems in the prior art of high positioning difficulty and inaccurate positioning of the cranial acoustic window.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

A plate-to-roller imprinting apparatus capable of manufacturing a large-area micro/nano-structure (220) on an optical glass plate (100), and a method for processing the micro/nano-structure (220) on the optical glass plate (100). The plate-to-roller imprinting apparatus comprises a roller module (1) and a workpiece support module (2). The roller module (1) comprises a roller (11); the workpiece support module (2) comprises a workpiece table (21); the workpiece table (21) is arranged below the roller module (1); a core plate (22) is provided on top of the workpiece table (21); the micro/nano-structure (220) is provided on an upper surface of the core plate (22); and a heating device (3) is provided in the workpiece table (21), and the heating device (3) is located below the core plate (22); the optical glass plate (100) is arranged on the upper surface of the core plate (22); and the heating device (3) is used for heating the optical glass plate (100). The roller (11) rolls so that pressure can be applied to the optical glass plate (100), and one of the roller (11) and the workpiece table (21) can move in a reciprocating manner in a direction perpendicular to the central axis of the roller (11).

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G02B 3/00 - Simple or compound lenses

Abstract

A method of training a learning network to perform image segmentation includes receiving training data from a trusted source and an alternative source; assigning weights to data in the second corpus; dividing the data into batches with samples from the first and second corpuses; and completing training epochs by, for each batch: generating an output for each sample; determining a loss by comparing the generated output with a ground truth for each sample; defining a discrepancy for each second corpus sample as a difference between the sample loss and the average loss for the first corpus, approximated as the average loss for the first corpus from the preceding epoch modified by a change in the average loss from the preceding to the current epoch; identifying weights for the next batch which minimise the weighted sum of discrepancies and network parameters which minimise the average weighted loss.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation

Abstract

A method for certifying a Science, Technology, Engineering and Mathematics (STEM) industrial product is provided. The method comprises: evaluating and scoring a STEM literacy level acquirable by using the product to thereby yield a first score for STEM literacy; evaluating and scoring product features findable in the product to thereby yield a second score for product features; evaluating and scoring general abilities learnable after using the product to thereby yield a third score for general abilities; making a final decision on a total score for the product according to the first, second and third scores; and awarding the product with a certification level according to the total score of the product.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

Abstract

The present invention provides an isolated glucoregulatory compound having both insulinotropic and blood glucose lowering activities, a composition and uses thereof for treating diseases associated with insulin deficiency or failure in glucose uptake independent of insulin secretion by pancreatic cells such as hyperglycemia, type 1 diabetes, or type 2 diabetes mellitus in a subject.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention provides an intelligent adaptive wavefront measurement system for optical characterization. The system can obtain optical parameters of a sample to be measured. The system comprises a light source, a shearing generator, and a photoelectric coupling device which are sequentially arranged in the axial direction, wherein the shearing generator comprises a spatial light modulator and a phase difference micro-lens array which are sequentially arranged in the axial direction. In addition, the present invention further provides a corresponding method and a training method in a simulation environment, such that a machine learning-based adaptive technology is used for wavefront modulation of the spatial light modulator.

IPC Classes  ?

• G01J 9/02 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength by interferometric methods

Abstract

The present disclosure provides a font generation model training method and a related device. The method comprises: obtaining a sample text image of a reference font, description information of a target font and a target text image of the target font, wherein the sample text image and the target text image comprise the same text; inputting the sample text image of the reference font and the description information of the target font into a font generation model to be trained, so as to obtain a predicted text image of the target font; and according to the predicted text image of the target font and the target text image of the target font, training a generative adversarial network comprising the font generation model and a discrimination network, so as to obtain a trained font generation model.

IPC Classes  ?

• G06V 30/19 - Recognition using electronic means

Abstract

A wireless charging system for providing multi-frequency and multi-speed charging modes to transfer power wirelessly from a base device to a remote device is disclosed. The wireless charging system includes a split transmitter having a plurality of sub-transmitters; a split receiver having a plurality of sub-receiver; and a switched-capacitor circuitry comprising a plurality of switched-capacitor switches. The plurality of sub-receivers and the plurality of sub-transmitters each comprises co-planar induction coils of non-equal cross-sectional lengths positioned concentrically without an interception. The split transmitter and the switched-capacitor circuitry are controlled by a hybrid pulse width modulation (PWM) control method, and the split receiver is controlled by a model predictive control method.

IPC Classes  ?

• H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
• H01F 27/28 - CoilsWindingsConductive connections
• H01F 38/14 - Inductive couplings
• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type

Abstract

The present application is applicable to the technical field of data processing, and provides a psychological stress level detection method, apparatus and system. The method comprises: obtaining the number of micro-gestures, i.e., the frequency of micro-gestures, performed by a user within a first preset period; and inputting the frequency of micro-gestures into a stress level detection model to obtain the stress level grade of the user. According to the method provided by the present application, the stress level grade of the user is determined according to the frequency of micro-gestures performed by the user, so that the accuracy of detecting the stress level grade of the user can be improved. Moreover, compared with determining the stress level grade of the user by means of recorded sound data or image data, the method can reduce the risk of leaking user privacy, and has wider application scenarios.

IPC Classes  ?

• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

A multifunctional charging circuit includes: a first inverter circuit connected to a primary side winding of an isolation transformer and configured to convert a received first direct current into a first alternating current, then outputting it to the primary side winding; a first wireless charging coil, with one end connected to a corresponding end of a secondary side winding of the isolation transformer, and designed to receive electrical power wirelessly transmitted by a second wireless charging coil; a first resonance compensation circuit connected to the other end of the first wireless charging coil and the corresponding end of the secondary side winding, and configured to generate a resonance based on the electrical power received by the first wireless charging coil and/or the first alternating current received by the secondary side winding, subsequently outputting a first charging current to the rectifier circuit.

IPC Classes  ?

• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• H02J 7/06 - Regulation of the charging current or voltage using discharge tubes or semiconductor devices

Abstract

A multi-dimensional intelligent garment pressure test dress form apparatus and system, and a multi-dimensional intelligent garment pressure test method. The intelligent garment pressure test dress form apparatus comprises an apparatus main body and a human body model (2), wherein the human body model (2) is circumferentially segmented into a plurality of model units (21) around an axis; and the apparatus main body comprises a plurality of movable members (6) and a control base (1). Each movable member (6) is circumferentially distributed on the control base (1) around the center of a circle, and each movable member (6) is movably arranged in a straight line where a connecting line between the center of the movable member and the center of a circle is located; the model units (21) are respectively mounted on the movable members (6) on a one-to-one basis; and the control base (1) is used for driving the movable members (6) to move together or separately, so that multiple dimensions of the size and shape of the human body module (2) can be adjusted and changed. Therefore, when applied to a garment pressure test, the dress form apparatus can implement an intelligent, dynamic and shape-adjustable garment pressure test which includes a plurality of human body sizes, without frequently changing the human body module (2), thereby realizing economic and effective garment functionality measurement.

IPC Classes  ?

• A41H 5/01 - Dress formsBust formsStands with means for adjustment, e.g. of height

Abstract

The present application relates to the technical field of medicine. Provided is the use of integrin α5β1 as a target in the screening of drugs for preventing and/or treating bone loss. 8-isoprenyl flavone glycoside can replace a ligand fibronectin on cell surface receptor integrin α5β1, thereby achieving the binding of 8-isoprenyl flavone glycoside to the integrin α5β1, and thus improving the osteogenesis ability and the cell adhesion. Therefore, by using integrin α5β1 as a target of a drug for preventing and/or treating bone loss, and by means of the binding of 8-isoprenyl flavone glycoside to integrin α5β1, the activities of ALP, RhoA and Rac1 in bone marrow mesenchymal stem cells can be significantly improved, thereby promoting the osteogenesis and the cell adhesion, promoting the development of drugs for bone loss, and providing a new strategy and routine for the treatment of bone loss diseases.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

A gait event-driven, phase-dependent and multi-modal foot rehabilitation system, and a use method thereof. The system comprises: a pressure sensor module (110) which measures a pressure distribution value of a foot sole in real time; a micro-control module (111) which compares the measured pressure value with a preset threshold value to identify different gait events in a dynamic gait and a pressure balance on the inner and outer sides of the foot sole and to control a corresponding operation in real time; a neuromuscular electrical stimulation module (100) which applies or stops a suprathreshold electrical stimulation delivered to a target muscle of the foot on the basis of the recognized gait event; a combined pneumatic musculo-skeletal module (200) which comprises a pneumatic muscle (305) and deflates or inflates the pneumatic muscle (305) on the basis of the recognized gait event; and a vibratory biofeedback module (109) which, when recognizing an imbalance of pressure between the inner side and the outer side of the foot sole, provides a biofeedback to correct the imbalance of force exerted by the foot sole. The gait events comprises heel striking, heel off and sole off. The system can correct foot drop and foot varus, mitigate muscle compensation and dystrophy, and restore a normal gait.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes

Abstract

An immersive projection system (100) is installed in an immersive room (150).The immersive room (150) comprises a ceiling having an opening and a floor. The immersive projection system (100) comprises an image generator (110) which configured to render images to be displayed, a projection warping system (120) which configured to warp and blend rendered images received from the image generator (110), and a plurality of projectors (155) which configured to project images output from the projection warping system (120) into the immersive room (150). One of the plurality of projectors (155) is configured to project images onto the floor through the opening.

IPC Classes  ?

• G03B 21/00 - Projectors or projection-type viewersAccessories therefor

Abstract

An immersive projection system comprises an image generator configured to render images to be displayed; a projection warping system configured to warp and blend rendered images received from the image generator; an immersive room including ceiling having an opening and floor; and a plurality of projectors configured to project images output from the projection warping system into the immersive room; wherein, one of the plurality of projectors is configured to project images onto the floor through the opening.

IPC Classes  ?

• H04N 13/363 - Image reproducers using image projection screens
• H04N 9/31 - Projection devices for colour picture display

Abstract

A Hybrid Interactive Virtual Environment (HiVE) system and a method of use thereof are provided, said system and method are configured for clinical education and training. Said system comprising: an immersive room, which is 6-sided Cave Automatic Virtual Environment (CAVE) platform and is configured to a fully immersive interactive hybrid classroom; an image generator, which is configured to process input contents and render the input contents in either two dimensional (2D) mode or three dimensional (3D) mode to generate interactive contents for clinical education and training; a projection warping system to perform a process of projection warping and blending to generate a projection warped display image; and a video processing system to process the projection warped display image to generate a frame-synchronized display output; wherein the immersive room comprises a surround sound system to produce audio output to the interactive contents, a motion capture system to produce tracking information of the users inside the immersive room and send the tracking information to the interactive contents, and projectors to project the frame-synchronized display output from the video processing system to generate a 3D interactive image within the immersive room for clinical education and training, such that users in the immersive room may watch and listen to the 3D image and interact with the 3D image and/or with each other for clinical education and training.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

An Internet-based infectious disease prevention and control training system and an Internet-based infectious disease prevention and control training method. The system comprises a resource database, an application server, a network medium, and an application program on an intelligent terminal; the resource database comprises a service database and a user information database; the service database comprises texts, audios, images, short videos, and game controls; the application server comprises an access management module, a resource scheduling module, a report generation module, and a network optimization module; the access management module authenticates, on the basis of the user information database, login request information sent by a user; the resource scheduling module schedules the texts, the audios, the images, the short videos, or the game controls in the service database according to an instruction sent by the application program, and presents the texts, the audios, the images, the short videos, or the game controls to the intelligent terminal by means of the network medium; the application program comprises a plurality of themes associated with an infectious disease prevention and control standard file; and each theme is presented in the form of one or more games.

IPC Classes  ?

• G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
• G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
• G06Q 50/20 - Education
• G06F 16/245 - Query processing

Abstract

Methods for treating or preventing a skeletal sequelae of a coronavirus infection in a subject in need thereof, the method comprising administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide. The skeletal sequelae can include one or more of arthralgia, viral arthritis, osteopenia, osteochondral damage, and osteoporosis.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 19/00 - Drugs for skeletal disorders
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present application discloses a current collector and a manufacturing method therefor, an electrode sheet, a battery, and an electric device. The current collector comprises a dense carbon nanotube film layer and a metal layer bonded to the surface of the dense carbon nanotube film layer. Compared with a commercial metal foil, the weight of the current collector provided by the present application is only 15%-19% of that of the commercial metal foil, and the thickness of the current collector is 24%-32% of that of the commercial metal foil; moreover, the current collector has similar conductivity and electrochemical stability, and the mechanical strength and flexibility of the current collector are greatly improved. The mass specific energy density and the volume specific energy density of a battery using the current collector are respectively increased by 10.2%-25.7% and 5.1%-11.45%.

IPC Classes  ?

• H01M 4/66 - Selection of materials

Abstract

Provided herein are methods and compositions useful for treating bacterial cell populations including bacterial persister cells and/or antibiotic resistant bacterial cells.

IPC Classes  ?

• A61K 31/4174 - Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/04 - Antibacterial agents

Abstract

This invention provides an all-in-one device for virus diagnosis, especially for a target nucleic acid sequence or target antigens or anitbodies in a single sample, comprising: a sample chamber for holding a cuvette with a UCNP-based assay and said sample; a NIR light source; a sensor for measuring fluorescence emission from a UCNP-based assay comprising a light-to-frequency converter; Optics providing an optical path ensuring only fluorescence emission from said UCNP-based assay reaches said sensor; and a microcontroller; wherein said UCNP-based assay is a system comprising UCNP surface modified with a first oligo probe and AuNP surface modified with a second oligo probe, wherein said first oligo probe and said second oligo probe are independently complimentary to separate segments on said target nucleic acid sequence that are nearby each other; or/and a system comprising ligand-free UCNP with electrostatic attraction to said target protein and AuNR surface modified with antibodies for said target protein.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

A vision improvement module, comprising: a screen (1), an optical path folding lens assembly (2) and a zooming mechanism. The optical path folding lens assembly (2) is disposed on a light-emitting side of the screen (1), and the zooming mechanism is connected to the screen (1) or the optical path folding lens assembly (2). The vision improvement module changes the distance from the screen (1) to the nearest lens according to the degree of myopia of a user, so that the user is able to clearly see the screen (1) with the naked eye. On the basis of foregoing, an imaging position is continuously changed by means of the axial reciprocating motion of the screen (1) within a certain length range, or the optical path folding lens assembly (2) is adjusted by means of the zooming mechanism, so as to continuously change the focal length, thereby adjusting the activity of the ciliary muscles in the eyes, and finally improving myopia.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02C 7/08 - Auxiliary lensesArrangements for varying focal length

Abstract

A computer-implemented method for training a convolutional neural network (CNN) using training data comprising a pair of original and downsampled 4D magnetic resonance imaging (MRI) data is provided. The CNN is used to generate multi-parametric 4D magnetic resonance (MR) images based on multi-parametric 3D MR images in real-time. The method includes receiving a 4D MR image formed by a plurality of fixed images of different frames; converting the plurality of fixed images into a plurality of k-space data by non-uniform fast Fourier transform (NUFFT); applying radial scan to the k-space data to simulate real-time MR image acquisition, and generating a plurality of downsampled fixed images by inverse NUFFT; training a CNN with training data comprising the 4D MR image and the corresponding downsampled 4D MR image; and estimating the multi-parametric 4D MR image in real-time by applying apply the predicted DVF to the multi-parametric 3D MR images.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G06T 7/00 - Image analysis

Abstract

Provided are a printing defect detection method and apparatus, and a device and a storage medium, which relate to the technical field of computers. The method comprises: acquiring an initial target image of a printed product to be subjected to detection; acquiring a reference image corresponding to said printed product; aligning the initial target image with the reference image in a plurality of modes, so as to respectively obtain a plurality of candidate transformed target images; determining a transformed target image on the basis of the degree of similarity between each of the plurality of candidate transformed target images and the reference image; performing color distribution feature standardization processing on the transformed target image on the basis of the reference image, so as to obtain a standardized transformed target image; and obtaining a final difference result on the basis of the standardized transformed target image and the reference image, so as to detect a printing defect of said printed product according to the final difference result.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

A permeable stretchable bioelectronic device with wafer-scale patterning capability including a stretchable and permeable substrate and one or more electronic components disposed on a surface of the substrate, wherein the stretchable and permeable substrate includes a biocompatible elastomeric fiber or a biocompatible hydrogel and the each of the one or more electronic components independently include a metal and a liquid metal and a method of fabrication thereof.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A multi-layered scaffold useful for osteochondral complex defects. The multi-layered scaffold can be prepared by photopolymerizing a multi-layer scaffold precursor including: a first layer disposed on a surface of a second layer, wherein the first layer includes a first tri-block poly(lactide-co-propylene glycol-co-lactide) dimethacrylate; and the second layer includes a second tri-block poly(lactide-co-propylene glycol-co-lactide) dimethacrylate, hydroxyapatite nanoparticles covalently conjugated to one or more hydroxyethyl methacrylate moieties via an optional linker, and a photoinitiator, wherein the nanoparticles comprise hydroxyapatite, tricalcium phosphate, silicon dioxide, bioglass, or a mixture thereof.

IPC Classes  ?

• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• A61K 38/18 - Growth factorsGrowth regulators
• A61L 24/02 - Surgical adhesives or cementsAdhesives for colostomy devices containing inorganic materials
• A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials

Abstract

A prosthetic hand device mountable on a residual limb of an amputee is provided. The prosthetic hand device includes a myoelectric hand having five mechanical fingers actuatable to provide multiple degrees of freedom of movement, a control assembly including an ultrasound module as a human-machine interface, wherein the ultrasound module is configured to acquire ultrasound images of a region of the residual limb, a transfer learning model having a convolutional neural network architecture for obtaining extracted features from the ultrasound images, and an artificial intelligence model executed by one or more processors and configured to classify the extracted features from the ultrasound images for determining a volitional movement of the amputee in real-time. The volitional movement is transmitted to the myoelectric hand to dynamically and proportionally control the five mechanical fingers based on at least the volitional movement.

IPC Classes  ?

• A61F 2/54 - Artificial arms or hands or parts thereof
• A61F 2/70 - Operating or control means electrical
• A61F 2/72 - Bioelectric control, e.g. myoelectric

Abstract

A prosthetic hand device mountable on a residual limb of an amputee is provided. The prosthetic hand device includes a myoelectric hand having five mechanical fingers actuatable to provide multiple degrees of freedom of movement, a control assembly including an ultrasound module as a human-machine interface, wherein the ultrasound module is configured to acquire ultrasound images of a region of the residual limb, a transfer learning model having a convolutional neural network architecture for obtaining extracted features from the ultrasound images, and an artificial intelligence model executed by one or more processors and configured to classify the extracted features from the ultrasound images for determining a volitional movement of the amputee in real-time. The volitional movement is transmitted to the myoelectric hand to dynamically and proportionally control the five mechanical fingers based on at least the volitional movement.

IPC Classes  ?

• A61F 2/70 - Operating or control means electrical
• A61F 2/58 - ElbowsWrists
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition

Abstract

A method of treating a coronavirus infection in a subject in need thereof, the method including administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61P 31/14 - Antivirals for RNA viruses
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

A data processing method and apparatus. The method comprises: a first device acquires first data, and inputs the first data into a trained task model to obtain a processing result output by the task model, wherein the task model comprises a pre-trained model and at least one prompt module, the pre-trained model is divided into a plurality of modules, and every two adjacent modules among the plurality of modules correspond to one of the at least one prompt module; and input data of a first module arranged at a start position among the plurality of modules comprises first data, and input data of any second module arranged behind the first module among the plurality of modules is determined according to a processing result output by a module previous to the second module and a correction factor output by a target prompt module. According to the method, on the basis that the structure of a pre-trained model is not changed, a correction factor is used to better stimulate the pre-trained model to migrate pre-training knowledge so as to perform pixel-level semantic annotation, thereby improving task processing precision.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

A method of preparing core-shell nanoparticles, the method comprising: contacting a mixture comprising a first metal oxide, a first encapsulating material comprising an alkali metal or alkaline earth metal, and a second encapsulating material comprising a second metal oxide with hydrogen gas at a temperature higher than the hydrogen reduction temperature of the first metal oxide and lower than the decomposition temperature of the first encapsulating material resulting in the reduction the first metal oxide and the formation of metal nanoparticles that are at least partially encapsulated with a bimetallic oxide comprising the alkali metal or the alkaline earth metal and the second metal oxide thereby forming the core-shell nanoparticles, wherein the Tammann temperature of the first encapsulating material is lower than the hydrogen reduction temperature of the first metal oxide.

IPC Classes  ?

• B01J 37/02 - Impregnation, coating or precipitation
• B01J 21/04 - Alumina
• B01J 23/76 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups

Abstract

The present disclosure provides an ultrathin and superlight glass-fiber based current collector enabling energy-dense flexible batteries, and a method for fabricating the current collector. This current collector includes a metal-coated glass-fiber fabric having metal-coated glass fibers, and the metal-coated glass fiber includes a surface-modified glass fiber covered by one or two metal layers.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/04 - Processes of manufacture in general
• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/74 - Meshes or woven materialExpanded metal
• H01M 50/141 - Primary casingsJackets or wrappings for protecting against damage caused by external factors for protecting against humidity
• H01M 50/491 - Porosity

Abstract

Provided are an optical fiber sensor and a magnetic field strength measuring apparatus. The optical fiber sensor comprises an optical fiber (2) and a magnetic component (1). At least one optical fiber (2) is provided. The optical fiber (2) extends in a preset direction. A preset position is provided in the extension length of the optical fiber (2), and a Bragg grating (21) is formed at the preset position. The magnetic component (1) is connected to the preset position of the optical fiber (2). The magnetic component (1) can generate a position offset under the action of magnetic force, so as to allow the Bragg grating (21) at the preset position to produce a bending deformation perpendicular to the preset direction. The magnetic field strength measuring apparatus comprises the optical fiber sensor. The optical fiber sensor aims to solve the technical problem of inaccurate magnetic field strength measurements caused by the use of a current-carrying conductor, which is susceptible to electromagnetic and radio frequency interference.

IPC Classes  ?

• G01R 15/24 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using light-modulating devices
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables
• G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday

Abstract

Cyclic 1,4,7-triazacyclononane-1,4,7-triacetic acid chelators and metal complexes comprising the same useful as positron emission tomography imaging agents, magnetic resonance imaging contrast agents, and computed tomography imaging agents, and optical imaging agents, and methods of use and preparation thereof.

IPC Classes  ?

• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 51/04 - Organic compounds
• C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

The present invention provides an integrated microfluidic-based device for establishing a wound infection in vivo model suitable for high throughput bioassay such as potential drug screening, in vivo dosing optimization, host-microbe or microbe-microbe interactions under the influence of specific agents of interest, and studying regulatory mechanisms of certain inflammatory diseases relating to or arising from the wound infection. The present invention allows direct qualitative and quantitative assessments of specific markers expressed due to the wound infection by one or more microbes devoid of cell sorting, isolation, or labelling as in other conventional in vivo models or methods.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

In generating training and testing datasets for machine learning, manual annotation of a large volume of data is impractical and expensive. A machine-learning model for detecting carcinoma (CA) from a whole slide image (WSI) processes average cellular features of cells identified on the WSI. Each cellular feature is a descriptive statistic of the cells, advantageously allowing the training and testing datasets to be constructed without a costly annotation process of pixelwise labelling each cell on a WSI training sample. Apart from predicting a CA case or a non-CA case for the WSI, the machine-learning model is also usable to: identify a suspicious CA case for priority assessment if a non-CA case is predicted for the WSI; generate a tumor probability heatmap of the WSI for visualizing potential CA regions on the WSI to assist pathological assessment; and assess quality control of a triage system before implementation in clinical setting.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A head-mount transcutaneous electrical nerve stimulation (TENS) device adapted to stimulate acupoints of a user transcutaneously when being worn on the head of the user is disclosed. The TENS device includes one or more frames, a plurality of contacts, a pulse width modulation (PWM) generator, and one or more thermal pads. The one or more frames are arranged to have a contour matching an anatomical shape of the head. The plurality of contacts is arranged on an inner surface of the one or more frames for contacting the acupoints on the head. The PWM generator is configured to generate a pulse stimulation signal and couple the pulse stimulation signal to the plurality of contacts for stimulating the acupoints. The one or more thermal pads are arranged on the inner surface of the one or more frames for applying thermal treatment to the acupoints.

IPC Classes  ?

• A61N 1/04 - Electrodes
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

Provided are an installation auxiliary tool for blind bolts, an installation kit and a use method therefor. The installation auxiliary tool for blind bolts (100) comprises a clamping assembly (10), a connection assembly (20), an elastic member (60) and a force transmission member (50). The clamping assembly (10) comprises two clamping arms (11), the two clamping arms (11) being arranged opposite to each other in a spaced-apart manner, and one end of each clamping arm (11) being a clamping end (111). Two ends of the connection assembly (20) are respectively and rotatably connected to the two clamping arms (11). Two ends of the elastic member (60) are respectively connected to the two clamping arms (11), and are used for driving the clamping ends (111) of the two clamping arms (11) to approach each other. The force transmission member (50) is located between the two clamping arms (11) and is in threaded connection with the connection assembly (20). The installation kit comprises a blind bolt (100) and said installation auxiliary tool, said installation auxiliary tool being used for assisting in installing the blind bolt (100). During use of the said installation auxiliary tool, the force transmission member (50) is rotated to convert the torque of the force transmission member (50) into an axial force, so as to easily push the blind bolt (100) to pass through an installation hole, thus effectively reducing physical exertion of operators, and helping to reduce the workload of the operators.

IPC Classes  ?

• B25B 27/14 - Hand tools or bench devices, specially adapted for fitting together or separating parts or objects whether or not involving some deformation, not otherwise provided for for assembling objects other than by press fit or detaching same
• F16B 13/06 - Dowels or other devices fastened in walls or the like by inserting them in holes made therein for that purpose with parts gripping in the hole or behind the reverse side of the wall after inserting from the front combined with expanding sleeve

Abstract

The present disclosure provides a system and method for precision tumor delineation in cancer treatment or diagnosis for subjects with carcinoma, in particular, nasopharyngeal carcinoma, based on contrast agent-free, virtual contrast-enhanced MRI data (VCE-MRI) synthesized by a modified multimodality-guided synergistic neural network trained with a more diversified training dataset and having a higher generalizability by minimizing data distribution variation between an external dataset and the training dataset through a data distribution matching mechanism before VCE-MRI synthesis.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06T 7/00 - Image analysis

Abstract

The present application relates to the technical field of 3D materials, and in particular, to a composite 3D printing material containing tea residues, a preparation method therefor and a use thereof. The provided composite 3D printing material containing tea residues comprises the following components in percentage by weight: 70-95% of a resin matrix and 5-30% of tea residues. It is ensured that the obtained composite 3D printing material has high tensile strength and maintains certain toughness, so that the composite 3D printing material containing tea residues can well meet the relevant technical requirements of FDM 3D printing, and realize a high printing success rate during the FDM 3D printing. Therefore, the provided composite 3D printing material containing tea residues achieves high value-added recycling of the tea residues, and is beneficial to environmental protection and cost reduction; additionally, the provided composite 3D printing material containing tea residues can better meet the functional requirements of routine 3D printing, and printed products have excellent comprehensive performance and a wide range of applications.

IPC Classes  ?

• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C08L 55/02 - ABS [Acrylonitrile-Butadiene-Styrene] polymers
• B33Y 70/00 - Materials specially adapted for additive manufacturing

Abstract

A novel pharmacologic treatment of refractive disorders including myopia and hyperopia is provided. The method of treating refractive disorders including myopia and hyperopia is mainly through targeting the Hippo biological pathway using agonists, antagonists or gene therapy targeting the HIPPO signaling, including MST1/MST2, LATS1/LATS2 kinases, and YAP/TAZ proteins. It is also found that the drug XMU-MP-1, a reversible and selective inhibitor of MST1/2, is a promising drug to target the Hippo biological pathway.

IPC Classes  ?

• A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
• A61P 27/02 - Ophthalmic agents
• A61P 27/10 - Ophthalmic agents for accommodation disorders, e.g. myopia

Abstract

In an indoor environment on fire, automatic deployment of sensors disposed on, beneath or over the floor to look upward the ceiling to observe a body of smoke and flame risen near the ceiling allows important information regarding states and dynamics of the body of smoke and flame to be gathered at an early stage of fire (e.g. before arrival of firefighters). By distributing the sensors over the indoor environment, the states and dynamics of the body of smoke and flame are monitored holistically (i.e. as a whole) even at the early stage of fire. Such information is useful to predict development of the fire. In one implementation, a sensor is held in an infrastructure sensor holder mounted on the ceiling during normal time. Upon detecting occurrence of fire, the sensor drops from the holder to land on the floor and orients a sensing direction vertically upward to perform monitoring.

IPC Classes  ?

• G01K 3/14 - Thermometers giving results other than momentary value of temperature giving differences of valuesThermometers giving results other than momentary value of temperature giving differentiated values in respect of space
• A62C 3/00 - Fire prevention, containment or extinguishing specially adapted for particular objects or places
• A62C 99/00 - Subject matter not provided for in other groups of this subclass
• G01K 13/00 - Thermometers specially adapted for specific purposes
• H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom

Abstract

A piezoelectric-photovoltaic integrated apparatus, a preparation method, and an application. The piezoelectric-photovoltaic integrated apparatus comprises a piezoelectric assembly and a photovoltaic assembly, wherein the piezoelectric assembly comprises a first piezoelectric electrode, a piezoelectric active layer and a second piezoelectric electrode; the photovoltaic assembly comprises a first photovoltaic electrode, a photovoltaic active layer, a hole transport layer and a second photovoltaic electrode; and in the direction from an outer layer to an inner layer, the second photovoltaic electrode, the hole transport layer, the photovoltaic active layer, the first photovoltaic electrode, the second piezoelectric electrode, the piezoelectric active layer and the first piezoelectric electrode are sequentially arranged in a cladding manner. A piezoelectric assembly and a photovoltaic assembly are integrated, thereby solving the problems in the prior art of a photovoltaic conversion device and a piezoelectric conversion device having the defect of intermittent power supply, and thus the application scenarios being limited. A two-dimensional/three-dimensional tin-based perovskite material is used for a photovoltaic active layer, so that the photovoltaic conversion efficiency is high, the properties are stable, and minor harm is caused. The apparatus can be widely applied to fabrics, wearable devices, mobile devices and sensors.

IPC Classes  ?

• H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors

Abstract

The present application provides a composite wrapped steel bar and a manufacturing method therefor, an on-site bending method, and an application. The composite wrapped steel bar comprises a steel bar of a core portion and a composite protection layer wrapped around the surface of the steel bar. The composite wrapped steel bar of the present application has the characteristics of corrosion resistance, impact resistance, peeling resistance, good bonding performance with concrete, and a price–performance ratio, etc. A concrete structure is enhanced by using the composite wrapped steel bar provided by the present application, so that the durability of the structure can be significantly improved, and the service life of the structure can be prolonged. The composite wrapped steel bar provided by the present application is suitable for infrastructure construction in corrosive environments, for concrete structures obtained by directly mixing sea water and sea sand, and for the construction of offshore islands and reefs having national defense and economic value.

IPC Classes  ?

• E04C 5/01 - Reinforcing elements of metal, e.g. with non-structural coatings

Abstract

Provided is a microbial system established based on a genetically modified bacterial strain under a genus of Pseudomonas with improved capacities to form more biofilms and trap more microplastics from a source than its wild-type form. In particular, the genetically modified bacterial strain is selected from P. aeruginosa, and the genetically modified P. aeruginosa is provided by adaptive mutation to a gene responsible for regulating an adhesion protein expression in an exopolymeric matrix of the biofilms. A method for recovering the microplastics trapped by the biofilms of this genetically modified bacterial strain is also provided.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C12R 1/385 - Pseudomonas aeruginosa

Abstract

Embodiments of the present disclosure provide a fuel cell power generation device, which includes: a fuel cell with an anode and a cathode, for decomposing hydrogen and generating electric energy through reaction of decomposed hydrogen and oxygen; a first delivery pipe connected between a pipeline of a hydrogen-containing gas and the fuel cell, for delivering the hydrogen-containing gas to the anode of the fuel cell; a first output pipe connected to the fuel cell, for discharging a first remaining gas contacted with the anode of the fuel cell; a second delivery pipe connected to the fuel cell, for delivering an oxygen-containing gas to the cathode of the fuel cell; and a second output pipe connected to the fuel cell, for discharging a second remaining gas contacted with the cathode of the fuel cell.

IPC Classes  ?

• H01M 8/04082 - Arrangements for control of reactant parameters, e.g. pressure or concentration
• H01M 8/04007 - Auxiliary arrangements, e.g. for control of pressure or for circulation of fluids related to heat exchange
• H01M 8/04089 - Arrangements for control of reactant parameters, e.g. pressure or concentration of gaseous reactants
• H01M 8/04746 - PressureFlow
• H01M 8/0662 - Treatment of gaseous reactants or gaseous residues, e.g. cleaning
• H01M 16/00 - Structural combinations of different types of electrochemical generators

Abstract

Sustainable upcycling method of preparing an electrocatalyst, the method including: providing an electrode material obtained from a lithium-ion battery, wherein the electrode material includes LiFePO4@N-doped carbon core-shell particles; contacting the electrode material with an aqueous solution comprising an acid thereby forming the electrocatalyst; and optionally drying the electrocatalyst.

IPC Classes  ?

• C01B 25/37 - Phosphates of heavy metals
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

Provided is use of Cs4-SeNPs in preparing a product for resisting neurodegeneration diseases such as Parkinson's disease.

IPC Classes  ?

• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 25/16 - Anti-Parkinson drugs

Abstract

44@N-doped carbon core-shell particles; contacting the electrode material with an aqueous solution comprising an acid thereby forming the electrocatalyst; and optionally drying the electrocatalyst.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• H01M 4/88 - Processes of manufacture
• H01M 4/90 - Selection of catalytic material
• H01M 12/08 - Hybrid cellsManufacture thereof composed of a half-cell of a fuel-cell type and a half-cell of the secondary-cell type

Abstract

The present invention provides a method for treating non-alcoholic fatty liver disease (NAFLD), associated conditions and symptoms. In particular, the method includes administering to a subject suffering from or susceptible to NAFLD a composition including therapeutic nucleic acids to reduce G protein-coupled receptor 110 (GPR110) expression in liver. The present invention also provides a pharmaceutical composition for treating NALFD or alleviating conditions and symptoms associated therewith.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

An intelligent cloth inspection detection system and method, and a readable medium and a product. A cloud server end (11) is connected to a plurality of cloth inspection machine clients (12), and receives a plurality of pieces of detection result information, which are sent by the plurality of cloth inspection machine clients (12), so as to obtain defect information of cloth corresponding to each cloth inspection machine client (12), such that a workplace of a cloth inspection worker can be changed from a cloth inspection workshop to a remote office, and the parallel management of a plurality of cloth inspection machines by fewer workers is realized; thus, the cloth detection efficiency is greatly improved.

IPC Classes  ?

• G01N 21/898 - Irregularities in textured or patterned surfaces, e.g. textiles, wood
• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation

Abstract

One embodiment provides a flexible robotic actuator for assisting a body part of a subject. The flexible robotic actuator comprises a soft body and at least one chamber. The soft body has a first side and a second side opposite the first side, and includes a patterned section on the first side. The at least one chamber is defined by the soft body and operatively driven by a pressurized fluid such that the soft body bends towards the patterned section and the bending angle of the soft body is limited by the patterned section.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators

Abstract

An eco-tile useful for promoting the growth of fauna and flora in an aquatic environment, the eco-tile including at least one type of cement; aggregates comprising at least two fine aggregates and coarse aggregates; and milled incineration sewage sludge ashes, wherein the at least two fine aggregates comprise dredged marine sediment, eco-concrete precursors thereof, and methods of use and preparation of the same.

IPC Classes  ?

• C04B 28/04 - Portland cements
• C04B 18/04 - Waste materialsRefuse
• C04B 18/10 - Burned refuse
• C04B 14/06 - QuartzSand
• C04B 20/00 - Use of materials as fillers for mortars, concrete or artificial stone according to more than one of groups and characterised by shape or grain distributionTreatment of materials according to more than one of the groups specially adapted to enhance their filling properties in mortars, concrete or artificial stoneExpanding or defibrillating materials
• C04B 24/20 - Sulfonated aromatic compounds
• C04B 28/28 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing organic polyacids, e.g. polycarboxylate cements
• C04B 24/26 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

Sub-ambient daytime radiative cooling (SDRC) coating comprising: an alkali activated metakaolin, BaSO4, and silica nanospheres, wherein the alkali activated metakaolin is prepared by reaction of metakaolin with an alkali activator comprising waterglass and a strong base selected from the group consisting of LiOH, NaOH, KOH, Ca(OH)2, Li2O Na2O, K2O, CaO, and a mixture thereof, a coating formulation comprising the same, and a method of preparation and use thereof.

IPC Classes  ?

• C09K 5/14 - Solid materials, e.g. powdery or granular
• C04B 12/00 - Cements not provided for in groups
• C04B 14/06 - QuartzSand
• C04B 20/00 - Use of materials as fillers for mortars, concrete or artificial stone according to more than one of groups and characterised by shape or grain distributionTreatment of materials according to more than one of the groups specially adapted to enhance their filling properties in mortars, concrete or artificial stoneExpanding or defibrillating materials
• C04B 22/14 - Acids or salts thereof containing sulfur in the anion, e.g. sulfides
• C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
• C04B 12/04 - Alkali metal or ammonium silicate cements

Abstract

The present application provides a control method, device, and system for rehabilitation training. The method comprises: in the process that a user performs rehabilitation training at a preset stimulation parameter, obtaining motion state information and central nervous information of the user, the preset stimulation parameter being a parameter used when an electrical stimulation device performs electrical stimulation on the user; determining a target stimulation parameter according to the motion state information, the central nervous information, and the preset stimulation parameter; and sending a first instruction to the electrical stimulation device, the first instruction being used for instructing the electrical stimulation device to perform electrical stimulation on the user at the target stimulation parameter. According to the method provided by the present application, the control device can adjust the stimulation parameter in time according to the recovery status of a patient, such that the rehabilitation training effect is improved.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof

Abstract

Provided is a protein including a polypeptide having at least 95%sequence homology with an amino acid sequence selected from a group consisting of SEQ ID NOs: 1 to 5, where the amino acid at position 70 of SEQ ID NOs: 1-5 must be cysteine. Also provided are a biosensor including the protein and methods of using the biosensor for identifying a beta-lactam and a beta-lactamase inhibitor.

IPC Classes  ?

• C07K 1/13 - Labelling of peptides
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C12N 15/55 - Hydrolases (3)
• C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A haptic glove apparatus wearable by a user for providing tactile and kinesthetic feedback is provided. The haptic glove apparatus includes a glove body and a haptic device coupled to the glove body. The glove body has a finger portion to cover one or more fingers of the user. The haptic device includes one or more anchors positioned at distal ends of the finger portion; one or more feedback modules; and a tendon routing arrangement. The tendon routing arrangement includes one or more tendon wires connecting between the one or more feedback modules and the one or more anchors for exerting a flexion tension and an extension tension on each of the one or more fingers. Each of the one or more feedback modules is configured to adjust the flexion tension and the extension tension to generate a resistive sensation for simulating a contact of a virtual object.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• A41D 19/00 - Gloves
• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

A water treatment system and corresponding method for removing contaminant from a feed solution (10) are provided. The system includes a hollow fiber membrane chemical reactor (HF-MCR)(101) and a magnetic field generator; or a magnetic confinement-enabled column reactor (MCCR)(201) comprising one or more column filters (210) and a magnetic field generator. The magnetic field generator is arranged to produce a magnetic field for realizing a magnetically confined zone (261) that results in a formation of a plurality of microwires (162) comprising the zerovalent iron (ZVI) nanoparticles or a plurality of ZVI wires (215) comprising ZVI microparticles. The plurality of microwires (162) can be a magnetic catalyst to enable catalytic degradation and chemical immobilization of the contaminant. The plurality of ZVI wires (215) can reduce aqueous As (Asaq) concentration in the feed solution(10) after the feed solution (10) is pumped through the one or more column filters (210).

IPC Classes  ?

• C02F 1/48 - Treatment of water, waste water, or sewage with magnetic or electric fields
• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
• C02F 9/00 - Multistage treatment of water, waste water or sewage

Abstract

A personal training system assisted by artificial intelligence (AI) has a personal training device and a control device. The personal training device includes a jacket and pants, and houses sensors at positions corresponding to a user's main muscle groups for monitoring the user's movement posture and muscle activity of the main muscle groups. The control device has a data preprocessing unit for processing detected-signal data of the sensors, a training analysis device for executing an AI algorithm to conduct fatigue analysis of the user's movement based on the user profile and the detected-signal data, and to make training load recommendations. The personal training system can simultaneously monitor posture, muscle activity and muscle fatigue in real time during the exercise; and use the AI algorithm to evaluate exercise performance and provide real-time feedbacks to improve the exercise and training efficiency, and reduce the risk of injury.

IPC Classes  ?

• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• A63B 71/06 - Indicating or scoring devices for games or players
• G06N 3/045 - Combinations of networks

Abstract

A ruthenium-based nickel-aluminum catalyst for catalytic production of nitrogen and hydrogen from ammonia, with ruthenium as the main active component, nickel oxide and alumina as the carrier, and one or more of alkali metals, such as sodium and potassium, or alkaline earth metals such as calcium as a promoter; and a method of preparing the catalyst including: (a) adding nickel oxide and alumina to a mixed solution comprising ruthenium ions or a promoter for impregnation; (b) drying and calcining the carrier comprising the ruthenium and the promoter obtained in step (a) for activation, to obtain the ruthenium-based nickel-aluminum catalyst.

IPC Classes  ?

• B01J 23/58 - Platinum group metals with alkali- or alkaline earth metals or beryllium
• B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia

Abstract

The present invention provides preparation of a cordyceps sinensis mycelium Cs4 polysaccharide protein functionalized nano-selenium hydrosol, and anti-cancer use thereof.

IPC Classes  ?

• A61K 38/02 - Peptides of undefined number of amino acidsDerivatives thereof
• A61K 36/07 - Basidiomycota, e.g. Cryptococcus
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 9/10 - DispersionsEmulsions
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 35/00 - Antineoplastic agents

Abstract

2+ compounds under an industrial applicable continuous flow condition with at least 1000-hour lifetime, and fabrication method thereof.

IPC Classes  ?

• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 3/07 - Oxygen containing compounds
• C25B 9/77 - Assemblies comprising two or more cells of the filter-press type having diaphragms
• C25B 11/056 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of textile or non-woven fabric
• C25B 11/069 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of at least one single element and at least one compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of two or more compounds
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 11/032 - Gas diffusion electrodes

Abstract

Provided are a jacquard knitted fabric allowing for multiple surface pattern designs, and a weaving method. The jacquard knitted fabric is formed by circularly weaving a plurality of knit units. Each knit unit has a front side (68) and a back side (69), and comprises a plurality of weft yarns, wherein each weft yarn is alternately woven in the front side (68) and the back side (69); each weaving line of the back side (69) comprises a plurality of loops/tucks and floating threads; loops and/or tuck columns and floating thread columns are alternately arranged in multiple weaving columns of the back side (69); and the loops located in the same weaving column of the back side (69) are reversely interlaced together.

IPC Classes  ?

• D04B 1/10 - Patterned fabrics or articles
• D04B 1/00 - Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes
• D04B 9/00 - Circular weft knitting machines with independently-movable needles

Abstract

A system for human-computer interaction and a textile for human-computer interaction. The system comprises: an image collection device, a micro-single-board computer, a light-source device and a textile, wherein the image collection device is used for collecting a biological-feature image; the micro-single-board computer is used for controlling, according to a recognition result of the biological-feature image, the light-source device to emit visible light of a target color; and the textile comprises light-emitting tissue, wherein the visible light of the target color, which is emitted by the light-source device, is transmitted by means of the light-emitting tissue, such that the textile presents the target color.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

A textile defect detection system, comprising: a transmission assembly (10), which is suitable for textile conveyance and comprises a first transmission section (102) and a second transmission section (104); an image acquisition assembly (20), which comprises a first frame (202) and a camera array (204), the camera array (204) acquiring an image of a textile passing through the first transmission section (102); an inspection assembly (30) opposite to the second transmission section (104); a control apparatus (40), which is electrically connected to the camera array (204) and suitable for receiving the image of the textile acquired by the camera array (204), and generates a marking instruction when detecting that there is a defect on the image of the textile; and a marking apparatus (50), which is provided at an output end of the transmission assembly (10), electrically connected to the control apparatus (40), and suitable for marking a textile defect on the basis of the marking instruction output by the control apparatus (40). A detection approach for textile defects in which machine inspection and manual detection are both taken into consideration is achieved, thereby facilitating the improvement of the accuracy of detecting the textile defects.

IPC Classes  ?

• G01N 21/898 - Irregularities in textured or patterned surfaces, e.g. textiles, wood

Abstract

In a facemask (100), atmospheric air is filtered by a disposable surgical mask (180) to form respirable air. The facemask (100) has a frame (150) formed with an interior cavity (151) for storing the respirable air to be breathed by the user. A thermoregulation unit (110) mounted to the frame (150) provides air conditioning to the respirable air by using a fan (421) to draw the respirable air from the cavity (151) to a heat exchanger (425) that contacts a thermoelectric module (410) to thermoelectrically transport heat to outside the frame (150), thereby cooling the drawn respirable air and condensing water vapor therein. The condensed water vapor is trapped by the heat exchanger (425). Cool and dry respirable air is released back to the cavity (151), thus providing thermal comfort to the user during breathing. A heat sink (432) contacted with the thermoelectric module (410) is used with a fan (431) to efficiently dissipate heat from the thermoelectric module (410) to outside the frame (150).

IPC Classes  ?

• A62B 9/00 - Component parts for respiratory or breathing apparatus
• A62B 23/02 - Filters for breathing-protection purposes for respirators

Abstract

A phase-shift modulated full-bridge power inverter comprises: a leading bridge leg comprising: a first power switch having a first power switch parasitic capacitance; and a second power switch having a second power switch parasitic capacitance. A lagging bridge leg comprises a third power switch having third power switch parasitic capacitance; and a fourth power switch having a fourth power switch parasitic capacitance. Each of the power 10 switches is switched on and off in a switching cycle. An augmented passive circuit comprises an inductor which combines with the third power switch parasitic capacitance and the fourth power switch capacitance to form a resonator when a first one of the third and fourth power switches is switched off and a second one of the third and fourth power switches is in a switched off state. Energy stored in the parasitic capacitance of the second one of the third 15 and fourth power switches is discharged before the second one of the third and fourth power switches is switched on.

IPC Classes  ?

• H02M 1/00 - Details of apparatus for conversion
• H02M 7/5387 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
• H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power

Abstract

Methods for preparing a monolayer or few-layer centimeter-scale crystalline black phosphorus film, products thereof, and electronic and optoelectronic devices including the same.

IPC Classes  ?

• C30B 23/06 - Heating of the deposition chamber, the substrate, or the materials to be evaporated
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C30B 29/02 - Elements
• H01L 21/78 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices
• C30B 23/02 - Epitaxial-layer growth

Abstract

A recombinant arginine deiminase including a fluorescent group attached via an optional linker to the side chain of a cysteine residue useful for qualitative and quantitative detection of L-arginine in a sample, and methods of use and preparation thereof.

IPC Classes  ?

• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

Provided herein is a metal coated textile substrate prepared by an ultrasonic irradiation deposition process involving depositing a first plurality of metal nanoparticles on a textile substrate by a first ultrasonic irradiation deposition process thereby forming a metal seeded textile substrate; and depositing a second plurality of metal nanoparticles on the metal seeded textile substrate by a second ultrasonic irradiation deposition process thereby forming the metal coated textile substrate.

IPC Classes  ?

• D06M 10/02 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements ultrasonic or sonicCorona discharge
• D06M 11/44 - Oxides or hydroxides of elements of Groups 2 or 12 of the Periodic TableZincatesCadmates
• D06M 23/08 - Processes in which the treating agent is applied in powder or granular form
• D06M 23/10 - Processes in which the treating agent is dissolved or dispersed in organic solventsProcesses for the recovery of organic solvents thereof
• D06M 11/46 - Oxides or hydroxides of elements of Groups 4 or 14 of the Periodic TableTitanatesZirconatesStannatesPlumbates

Abstract

Provided in the present application are a method and apparatus for intelligent clothing matching, and an electronic device and a storage medium. The method comprises: acquiring a first clothing image and a second clothing image; performing feature extraction on the first clothing image and the second clothing image, so as to obtain a feature value of a first clothing element of the first clothing image, a feature value of a second clothing element of the first clothing image, a feature value of a first clothing element of the second clothing image and a feature value of a second clothing element of the second clothing image; determining a first matching compatibility and a second matching compatibility between the first clothing image and the second clothing image; generating a clothing matching compatibility and a matching level between the first clothing image and the second clothing image according to the first matching compatibility and the second matching compatibility; and generating a clothing matching combination. By means of the method, a clothing matching combination having a better matching effect can be automatically generated according to a clothing matching compatibility and a matching level of clothing images, thereby improving the efficiency of generating the clothing matching combination, and improving the user experience.

IPC Classes  ?

• G06F 16/535 - Filtering based on additional data, e.g. user or group profiles

Abstract

A color unit determination method and apparatus, an electronic device, and a storage medium. The method comprises: acquiring a color value range of a plurality of initial color units and colors comprised in the initial color units (S202); determining, according to a color value of each color comprised in each initial color unit, a maximum color difference value between the initial color units (S204); if the maximum color difference value between the initial color units does not satisfy a preset condition, adjusting the color value range of the initial color units and the colors comprised in the initial color units (S206); and if the maximum color difference value between the initial color units satisfies the preset condition, determining the initial color units as target color units (S208). According to the method, more accurate target color units can be obtained, so that the accuracy of color matching according to the target color units is improved, and a matching effect of color related tasks is improved.

IPC Classes  ?

• G06T 7/90 - Determination of colour characteristics

Abstract

In estimating a position of a vehicle utilizing a global navigation satellite system (GNSS), it is desirable to exclude outliner GNSS measurements due to navigation signals via non-light-of-sight paths from the GNSS to the vehicle, but it leads to a distorted satellite geometry distribution. Complementariness between low-lying visual landmarks and healthy but high-elevation satellite measurements is explored to improve the geometry constraint. Measurements of an inertial measurement unit, low-lying visual landmarks captured by a forward-looking camera onboard the vehicle, and healthy but high-elevation satellite measurements are tightly-coupled integrated via sliding window optimization of system states used in a factor graph. To improve estimation performance, good initial guesses of system states are important. As such, initial guesses of velocity set and position set inside a sliding window are estimated simultaneously based on data of Doppler measurement, double-differenced (DD) pseudorange measurement and DD carrier-phase measurement as obtained in GNSS measurements.

IPC Classes  ?

• G01S 19/45 - Determining position by combining measurements of signals from the satellite radio beacon positioning system with a supplementary measurement

Abstract

Peptide sequencing is important in decoding data stored in a data-encoded peptide. Tandem mass spectrometry (MS/MS) is particularly useful for peptide sequencing. In a computer-implemented method for sequencing the data-encoded peptide from an experimental spectrum, raw data of the experimental spectrum are first preprocessed to remove uninterpretable peaks to yield preprocessed data. A first set of one or more candidate sequences contending for a peptide sequence of the peptide is identified from a spectrum graph. The spectrum graph is formed according to the preprocessed data rather than the raw data for generating a fewer number of candidate sequences to thereby reduce a time cost in sequencing. The first candidate-sequence set is then processed to estimate the peptide sequence to thereby obtain a set of peptide-sequence estimate(s). Each estimate is verified whether it is invalid. The set of peptide-sequence estimate(s) is purged to remove any invalid estimate.

IPC Classes  ?

• G16B 50/30 - Data warehousingComputing architectures
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G06F 16/901 - IndexingData structures thereforStorage structures
• G06F 16/215 - Improving data qualityData cleansing, e.g. de-duplication, removing invalid entries or correcting typographical errors

Abstract

A high filtration filter for filtering aerosols with low pressure drop across the filter and reduced cake formation when the aerosols penetrate through from an upstream side to a downstream side is disclosed. The filter (100) includes a plurality of module layers (110) and a plurality of separators (120). An individual module layer is an electrostatically-charged polyvinylidene fluoride (PVDF) nanofiber mat. The electrostatically-charged PVDF nanofiber mat with charged nanofibers is configured to better capture aerosols. The plurality of module layers and the plurality of separators are alternatingly stacked and connected to one another. Each of the individual module layers has an appropriate fiber basis weight, thereby the aerosols are captured by the charged nanofibers and distributed uniformly across an entire width of the filter from the upstream side (41) to the downstream side (42). The fiber basis weight of nanofibers is selected to minimize the formation of skin leading to formation of a cake layer on the upstream side of the filter module. The filter also carries antimicrobials to disinfect bacteria, viruses, and harmful microbials carried by the trapped aerosols in the filter.

IPC Classes  ?

• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres

Abstract

A head-mount transcutaneous electrical nerve stimulation (TENS) device (100) is adapted to stimulate acupoints of a patient transcutaneously for treating or preventing dementia when being worn on the head (20) of the patient. The TENS device (100) includes one or more frames (200), a plurality of contacts (300), a pulse width modulation (PWM) generator (740), and one or more thermal pads (340). The one or more frames (200) are arranged to have a contour matching an anatomical shape of the head (20). The plurality of contacts (300) is arranged on an inner surface of the one or more frames (200) for contacting the acupoints on the head (20). The PWM generator (740) is configured to generate a pulse stimulation signal and couple the pulse stimulation signal to the plurality of contacts (300) for stimulating the acupoints. The one or more thermal pads (340) are arranged on the inner surface of the one or more frames (200) for applying thermal treatment to the acupoints.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 2/00 - Magnetotherapy
• A61N 2/02 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Abstract

A knee mounting device (100) for providing TENS treatment is disclosed. The knee mounting device (100) is coupled to a patient's knee to locate and stimulate ST-36 acupoint (12) transcutaneously for treating or relieving osteoarthritic pain. The knee mounting device (100) includes a lower assembly (120) mountable onto a leg portion under a kneecap (11), an upper assembly (110) mountable on a thigh, and a sleeve (140) adapted to connect the upper and lower assemblies (110,120). The lower assembly (120) includes a plurality of contacts (620) arranged for contacting the ST-36 acupoint (12), and a thermal pad (630) arranged for applying thermal treatment to an area proximate to the ST-36 acupoint (12). The upper assembly (110) includes a pulse width modulation (PWM) generator (740) configured to generate a pulse stimulation signal and couple the pulse stimulation signal to the contacts (620) for stimulating the ST-36 acupoint (12). The sleeve (140) is provided with a kneecap opening (141) located to enwrap the patient's knee as anchor and place the contacts (620) on top of the ST-36 acupoint (12).

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
• A61N 1/04 - Electrodes

Abstract

A 2D phased array ultrasound device possessing ultrahigh spatial resolutions (< 90 µm) and high centre frequency ( 25 MHz) including: a 2D array of piezo crystal elements formed from the kerfing of a single crystal; a series of conductive electrodes formed on opposed sides of the piezo crystal elements; a series of front matching layers; and a backing unit comprising backing filler material and a series of flexible circuit layers sandwich together to interconnect the back surface electrodes of the piezo crystal elements.

IPC Classes  ?

• B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• G01N 29/34 - Generating the ultrasonic, sonic or infrasonic waves
• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging

Abstract

Provided herein are bispecific antibodies synthesized by a one-pot chemical reaction including cyclization of tumor-targeting peptides and conjugation of the cyclized tumor-targeting peptides on the surface of monoclonal antibody to create a new form of bispecifics, named the peptidic bispecific antibodies (pBsAb), which combines the merits of monoclonal antibody and serum stable tumor-targeting cyclic peptides, giving the monoclonal antibody an additional targeting ability to form a bispecific antibody. The proposed pBsAb exhibits activities to initiate cell-cell interaction between cancer cell and macrophage, followed by antibody-dependent cellular phagocytosis. The one-pot synthesis can also be applied to conjugate other tumor-targeting molecules with various forms of immunoglobulins to generate bispecifics for use in immunotherapy, medicament for different pathogenic infections, and medical/clinical diagnosis.

IPC Classes  ?

• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 16/46 - Hybrid immunoglobulins
• C12N 15/13 - Immunoglobulins

Abstract

A methods, devices and computer readable media for anomaly detection of a substance method for anomaly detection of a substance. In an embodiment, the method comprises obtaining a first set of chemical fingerprints, wherein each chemical fingerprint of the first set of chemical fingerprints is indicative of a plurality of physiochemical properties for each sample in a set of normal samples of the substance (202); converting the first set of chemical fingerprints into a cluster of data points in a multi-dimensional principal component analysis (PCA) plot, wherein each dimension of the multi-dimensional PCA plot is based on a principal component (PC), each PC corresponding to one of the plurality of physiochemical properties (204); constructing a profile pattern of the cluster of data points as a prediction model configured to identify a new sample with a chemical fingerprint falling outside of the profile pattern as an anomaly (206); and optimizing the prediction model using a second set of chemical fingerprints, wherein the second set of chemical fingerprints are indicative of the plurality of physiochemical properties for a set of testing samples that include both a plurality of normal testing samples and a plurality of abnormal testing samples of the substance (208).

IPC Classes  ?

• G06K 9/62 - Methods or arrangements for recognition using electronic means
• G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Abstract

In anomaly detection of a substance, a first set of chemical fingerprints is obtained. Each fingerprint in the first set is indicative of a plurality of physiochemical properties for a normal sample of the substance. The first set is converted into a cluster of data points in a multi-dimensional principal component analysis (PCA) plot. Each dimension of the plot is based on a principal component (PC) corresponding to one of the physiochemical properties. A profile pattern of the cluster of data points is constructed as a prediction model to identify a new sample with a chemical fingerprint outside the profile pattern as an anomaly. The prediction model is optimized using a second set of chemical fingerprints. Each chemical fingerprint in the second set is indicative of the plurality of physiochemical properties for testing samples that include normal testing samples and abnormal ones of the substance.

IPC Classes  ?

• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 33/04 - Dairy products

Abstract

Composites of metal-organic framework particles and bacterial cellulose, methods of making the composites, and methods of using the composites in the hydrolysis of organic compounds are provided. The composites, which are aerogels comprising metal-organic framework particles embedded in a bacterial cellulose nanofiber network, are fabricated using a microbial synthesis strategy in which bacterial cellulose nanofiber is biosynthesized using a cellulose-producing bacteria in a fermentation medium in which metal-organic framework particles are dispersed.

IPC Classes  ?

• C08L 1/02 - CelluloseModified cellulose
• C12N 1/20 - BacteriaCulture media therefor
• C12N 1/22 - Processes using, or culture media containing, cellulose or hydrolysates thereof
• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Abstract

A technology for inhibition of myopia progression adapted to the RPR of the wearer is provided. A spectacle lens and related technology are provided that include a base area that causes a beam that enters through an object-side surface to exit through an eye-side surface and converge on a retina via the eye, and a plurality of defocus areas that each contact the base area and have a characteristic whereby a beam that passes through at least a portion of the defocus area is incident on the retina as a diverging ray, and, in not less than half of the plurality of defocus areas, at least one of a defocus power and a size of each defocus area is set, so as to compensate for a change in retinal spot size due to relative peripheral refraction (RPR) that depends on an eccentricity angle of the eye of the wearer.

IPC Classes  ?

• G02C 7/02 - LensesLens systems

Abstract

A transparent ultrasound transducer device for multi-mode optical imaging on a target is provided. The device includes a transparent piezoelectric transducer, one or more wires, and an optical lens. The transparent piezoelectric transducer of a first acoustic impedance is configured to receive acoustic waves from the target. The transparent piezoelectric transducer has a first surface and a second surface. The first surface and the second surface are coated with transparent electrically conductive coatings. The optical lens is contacted with and optically coupled to the first surface of the transparent piezoelectric transducer. The optical lens is made of a material with a second acoustic impedance, and the first and second acoustic impedances are substantially similar to minimize an acoustic impedance mismatch such that sensitivity of the device is improved.

IPC Classes  ?

• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
• G10K 11/30 - Sound-focusing or directing, e.g. scanning using refraction, e.g. acoustic lenses
• G02B 3/00 - Simple or compound lenses

Abstract

A sweating simulator has a foundation panel (14), a panel (1) and a temperature control panel (2), a fixture for fixing a specimen, a container (7) for holding simulated sweat, a container (15) for collecting the simulated sweat, and a plurality of weighing scales for measuring masses of the simulated sweat supplied, evaporated and dripped from the specimen, respectively. The panel (1) and temperature control panel (2) constitute a simulated sweating plane for simulating wetting properties and temperature of skin. An upper middle position of the temperature control panel (2) has a sweating zone (3), which has a plurality of sweating pores (4). The temperature control panel (2) has a temperature sensor (8) and a heating element to control the temperature of the temperature control panel (2) around 33-35° C. to simulate the temperature of the human skin surface. The sweating rate of the sweating zone (3) is in the range of about 1 to 624 ml/h or about 0.004 to 2.5 L/h-m2 to simulate various sweating intensities.

IPC Classes  ?

• G09B 23/30 - Anatomical models
• G05D 23/19 - Control of temperature characterised by the use of electric means
• G05D 7/06 - Control of flow characterised by the use of electric means
• G05D 27/02 - Simultaneous control of variables covered by two or more of main groups characterised by the use of electric means
• G01G 17/04 - Apparatus for, or methods of, weighing material of special form or property for weighing fluids, e.g. gases, pastes
• G01N 11/04 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Provided herein are a controllable liquid transport material, a controllable liquid transport system and a method for preparing a controllable liquid transport material, where a first region of the controllable liquid transport material is treated to be hydrophobic, while a plurality of second regions partially contacted or completely separated with different shapes are treated to have a gradient or varied wettabilities and/or pore sizes for passively controllable liquid transport, and/or integrated with a smart material for actively controllable liquid transport driven by an external force, allowing efficiently and controllably directional transport of a liquid e.g., sweat. The controllable liquid transport system comprises a controllable liquid transport material used as a liquid transport layer and a breathable, waterproof protective layer.

IPC Classes  ?

• B01D 61/42 - ElectrodialysisElectro-osmosis
• B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• A41D 31/10 - Impermeable to liquids, e.g. waterproofLiquid-repellent
• D03D 15/50 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads
• D04B 1/16 - Other fabrics or articles characterised primarily by the use of particular thread materials synthetic threads
• D04B 21/00 - Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes
• D06M 14/04 - Graft polymerisation of monomers containing carbon-to-carbon unsaturated bonds on to fibres, threads, yarns, fabrics or fibrous goods made from such materials on to materials of natural origin of vegetal origin, e.g. cellulose or derivatives thereof
• D06M 23/16 - Processes for the non-uniform application of treating agents, e.g. one-sided treatmentDifferential treatment
• D06M 14/22 - Graft polymerisation of monomers containing carbon-to-carbon unsaturated bonds on to fibres, threads, yarns, fabrics or fibrous goods made from such materials using wave energy or particle radiation on to materials of natural origin of vegetal origin, e.g. cellulose or derivatives thereof
• D06M 10/02 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements ultrasonic or sonicCorona discharge
• D06M 11/46 - Oxides or hydroxides of elements of Groups 4 or 14 of the Periodic TableTitanatesZirconatesStannatesPlumbates
• D06M 15/356 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of other unsaturated compounds containing nitrogen, sulfur, silicon or phosphorus atoms
• D06M 15/63 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing sulfur in the main chain, e.g. polysulfones

Abstract

A bio-inspired imaging device mimicking visual adaptation of human vision provides a large dynamic range in imaging an image. The device employs a neuromorphic vision sensor realized with phototransistors each being a field-effect transistor, a channel layer of which is an atomically-thin layer of two-dimensional semiconductor material. The channel layer is intentionally formed with defects trap states for trapping a portion of charge carriers generated by a light beam incident on the phototransistor such that intensity information of the light beam is memorized. A gate-source voltage directs the defects trap states to de-trap the trapped portion of charge carriers or to further trap an additional portion of charge carriers, allowing the phototransistor to exhibit a time-dependent excitation or inhibition effect on drain current to thereby enable the imaging sensor to mimic scotopic or photopic adaptation in imaging the image.

IPC Classes  ?

• H01L 27/146 - Imager structures
• H01L 31/112 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by field-effect operation, e.g. junction field-effect photo- transistor
• H01L 31/0296 - Inorganic materials including, apart from doping material or other impurities, only AIIBVI compounds, e.g. CdS, ZnS, HgCdTe

Abstract

A rotary motion generator (200) for helping a patient to relearn walking, includes a rotary shaft (204), a moveable lever (213), and a first elastomeric structure (201). The rotary shaft (204) is switchable between a one-way rotation mode and a two-way rotation mode in a sagittal plane, and locking the joint position by the one-way rotation mode. The moveable lever (213) protrudes from an outer periphery of the rotary shaft (204) perpendicularly for rotating the rotary shaft (204). The first elastomeric structure (201) is pneumatically controlled for engaging the moveable lever (213) for generating an output torque (302) and producing the relative rotatory movement of a lower arm (101) with respect to an upper arm (102). The rotary shaft (204) further comprises a pawl (208), a second elastomeric structure (209) for projecting or retracting the pawl (208), and a rotation locking mechanism (206) that switches the rotary shaft (204) between the one-way rotation mode and the two-way rotation mode.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators
• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

An ankle exoskeleton device (100) for helping a patient to relearn walking is disclosed. The ankle exoskeleton device (100) includes a leg brace (101), and insole (102), and a rotary actuator (400). The rotary actuator (400) is pneumatically driven to cause rotation of the insole (102) with respect to the leg brace (101) about a central axis (411). The rotary actuator (400) comprises first and second elastomeric structures (403A, 403B), a rotary shaft (402) rotatable about the central axis (411) to generate an output torque for producing a relative rotational movement of the insole (102), and a lever (410). The rotary shaft (402) is adapted to be moved by controlling two opposing fluid pressures inside the rotary actuator (400). The first elastomeric structure (403A) is extendable to push the lever (410) in a clockwise direction, and the second elastomeric structure (403B) is extendable to push the lever (410) in an anticlockwise direction, thereby the first and second elastomeric structures (403A, 403B) are arranged to control the rotary shaft (402).

IPC Classes  ?

• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• F15B 15/00 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith

Abstract

The present invention provides a universal fluorescent probing system and method for result readout of loop-mediated isothermal amplification (LAMP) or reverse transcription-loop-mediated isothermal amplification (RT-LAMP) in a closed-tube manner using at least three different types of universal quantum dot probes, including sulfonate-, carboxyl-, and amine-modified quantum dots (QDs). Detection mechanism of the present system and method relies on a co-precipitation of the modified QDs with magnesium pyrophosphate crystals (one of the positive LAMP/RT-LAMP reaction products) formed during the reaction. The present system and method are advantageous over the existing technologies in terms of simple preparation, low cost, as well as excellent universality, specificity and sensitivity.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Methods and systems useful for machine learning assisted imaging and detection of peripheral nerves comprising reflectance imaging spectroscopy. The method can be conducted label-free and in real-time.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/64 - FluorescencePhosphorescence