Abstract

A method for differentiating induced pluripotent stem cells (iPSCs) into retinal ganglion cells (RGCs) involves deleting a sequence encoding LNC000093 long non-coding RNA from the iPSC genome, culturing the modified iPSCs to generate colonies, and dissociating these colonies to form embryoid bodies. The embryoid bodies are transferred to a first plate to induce neural rosette formation. The neural rosettes are detached and cultured in suspension to develop into neurospheres, which are subsequently transferred to a second plate to promote differentiation into RGCs.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/079 - Neural cells
• C12N 5/0797 - Stem cellsProgenitor cells
• C12N 5/074 - Adult stem cells

Abstract

This application relates to an automated data management system and a corresponding method. The system comprises: a data collection module for gathering raw job position data from public resources; a data preprocessing module for preprocessing the collected raw job position data to remove irrelevant information and/or symbols; a data identification module for identifying text related to job skill requirements from the pre-processed data and identifying keywords related to the job skills; a semantic analysis module for semantically analysing the identified keywords related to the job skills and forming a skill classification scheme; a data storage module for establishing a skill database based on the skill classification scheme and storing the skill classification scheme. The system automates the analysis of job postings to identify the most in-demand skills in the current market. Through big data analysis, this invention accurately assesses the demand for various skills, providing valuable data support for job seekers and companies.

IPC Classes  ?

• G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations

Abstract

A personal cooling enclosing material comprises a garment body; an air cooling system provided on an outside surface of the garment body, wherein the air cooling system further comprises a receptacle and a coolant contained in the receptacle; and an air circulation system provided on an inside surface of the garment body for drawing original air from an internal space inside the garment body for cooling. The air circulation system is separated from the air cooling system to avoid direct contact of the original air with the coolant of the air cooling system. The air cooling system is in thermal communication with the air circulation system.

IPC Classes  ?

• A41D 13/005 - Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches with controlled internal environment with controlled temperature
• A41D 1/00 - Garments
• A41D 27/20 - PocketsMaking or setting-in pockets
• A41D 27/28 - Means for ventilation

Abstract

A generator module comprises a stator, a rotator and a mechanical switch. The stator comprises a first group of patterned conductive coatings, a second group of patterned conductive coatings, a first group of dielectric sectors and a second group of dielectric sectors. The rotator comprises a third group of patterned conductive coatings and a third group of dielectric sectors. The first group of patterned conductive coatings electrically connects to a first electrical terminal. The second group of patterned conductive coatings electrically connects to a second electrical terminal. The third group of patterned conductive coatings electrically connects to a third electrical terminal. The mechanical switch allows the third electrical terminal to be selectively connectable to one of the first electrical terminal and the second electrical terminal.

IPC Classes  ?

• H02N 1/08 - Influence generators with conductive charge carrier, i.e. capacitor machines

Abstract

A method for controlling noise for a human subject comprise receiving an acoustic signal by the human subject through a headphone, the acoustic signal comprising a noise signal, generating a cancellation signal based on a hearing target curve that is related to acoustic magnitude and frequency, and applying the cancellation signal to the acoustic signal such that the noise signal is attenuated.

IPC Classes  ?

• G10K 11/178 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effectsMasking sound by electro-acoustically regenerating the original acoustic waves in anti-phase
• A61B 5/372 - Analysis of electroencephalograms

Abstract

A transistor comprising: a source electrode; a drain electrode; a channel comprising an organic semiconductor between the source electrode and the drain electrode; a plurality of gate electrodes; and an electrolyte, wherein the electrolyte contacts the gate electrodes and the channel, and wherein at least one gate electrode comprises an oxidoreductase and at least one gate electrode does not comprise an oxidoreductase, and methods for detecting and/or determining the concentration of an analyte in a sample using the transistor comprising: (i) applying a voltage to the at least one gate electrode which does not comprise an oxidoreductase; (ii) contacting the test sample in the transistor; (iii) applying the voltage used in (i) to the at least one gate electrode which comprises an oxidoreductase, (iv) removing the voltage from the at least one gate electrode which does not comprise an oxidoreductase; wherein (iii) and (iv) occur simultaneously.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

A hoisting posture control system and method, applicable to the technical field of modular construction. According to the hoisting posture control system, controllers corresponding to functional modules are called on the basis of data detected by sensors, to drive posture control of a hoisted object, thereby assisting a tower crane operator in making work decisions, so that the operator does not need to take risks to get close to a module to be installed hoisted in the air, ensuring the safety of workers and the accuracy and reliability of module installation. Thus, the labor cost in modular construction work can be reduced, and the assembly quality and efficiency of modules are improved.

IPC Classes  ?

• B66C 13/08 - Auxiliary devices for controlling movements of suspended loads, or for preventing cable slack for depositing loads in desired attitudes or positions
• B66C 13/06 - Auxiliary devices for controlling movements of suspended loads, or for preventing cable slack for minimising or preventing longitudinal or transverse swinging of loads
• B66C 13/48 - Automatic control of crane drives for producing a single or repeated working cycleProgramme control
• B66C 13/16 - Applications of indicating, registering, or weighing devices
• B66C 1/12 - Slings comprising chains, wires, ropes, or bandsNets

Abstract

A hoisting position and posture adjustment system and a hoisting apparatus. The hoisting apparatus comprises the hoisting position and posture adjustment system, wherein the hoisting position and posture adjustment system comprises a posture adjustment device (20), a hoisting frame (11), a horizontal-displacement adjustment device (13) and a lifting spreader (12) which are sequentially arranged in a vertical direction, the lifting spreader (12) being connected to the hoisting frame (11) or the horizontal-displacement adjustment device (13) and configured to connect to a hoisted object (300); the horizontal-displacement adjustment device (13) is connected to the hoisting frame (11) and is configured to adjust the horizontal position of the hoisted object (300); and the posture adjustment device (20) is connected to the hoisting frame (11) and is configured to adjust the posture of the hoisted object (300), so as to keep the hoisted object (300) in a horizontal posture. By means of the cooperation of the horizontal-displacement adjustment device and the posture adjustment device, the hoisting position and posture adjustment system of the present application can automatically fine-tune the position and posture of a hoisted object, such that the amount of manual participation can be significantly reduced, thereby facilitating a reduction in labor costs and safety risks; moreover, the hoisted object can be accurately placed at a target position, thereby reducing the dependence on workers.

IPC Classes  ?

• B66C 13/08 - Auxiliary devices for controlling movements of suspended loads, or for preventing cable slack for depositing loads in desired attitudes or positions
• B66C 1/12 - Slings comprising chains, wires, ropes, or bandsNets

Abstract

A 2D phased array ultrasound device possessing ultrahigh spatial resolutions (<90 μm) and high centre frequency (25 MHz) including: a 2D array of piezo crystal elements formed from the kerfing of a single crystal; a series of conductive electrodes formed on opposed sides of the piezo crystal elements; a series of front matching layers; and a backing unit comprising backing filler material and a series of flexible circuit layers sandwich together to interconnect the back surface electrodes of the piezo crystal elements.

IPC Classes  ?

• B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
• G10K 11/30 - Sound-focusing or directing, e.g. scanning using refraction, e.g. acoustic lenses
• H10N 30/063 - Forming interconnections, e.g. connection electrodes of multilayered piezoelectric or electrostrictive parts
• H10N 30/088 - Shaping or machining of piezoelectric or electrostrictive bodies by machining by cutting or dicing
• H10N 30/20 - Piezoelectric or electrostrictive devices with electrical input and mechanical output, e.g. functioning as actuators or vibrators
• H10N 30/80 - Constructional details
• H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals
• H10N 39/00 - Integrated devices, or assemblies of multiple devices, comprising at least one piezoelectric, electrostrictive or magnetostrictive element covered by groups

Abstract

The present disclosure provides a feature selection method based on fuzzy label relaxation, which comprises the following steps: (a) acquiring sample data, and performing feature extraction on the sample data to obtain a feature data matrix; (b) learning a fuzzy membership to obtain a fuzzy membership matrix; (c) performing soft relaxation on a label matrix with the fuzzy membership matrix, and constraining a feature selection matrix to be row sparse; and (d) based on the steps (b) and (c), obtaining an objective function of the feature selection based on label fuzzy relaxation, and solving the objective function. In addition, the present disclosure further provides a feature selection system based on label fuzzy relaxation.

IPC Classes  ?

• G06N 7/02 - Computing arrangements based on specific mathematical models using fuzzy logic

Abstract

Disclosed in the present application is an energy management method for solar freezer trucks, the solar freezer truck includes a photo-voltaic (PV) module, a first battery, a freezer compressor, an engine generator, and an external power adapter connected by an energy management unit, and the energy management method includes obtaining an output power of the PV module; and switching, by the energy management unit, power paths to the freezer compressor according to the output power of the PV module.

IPC Classes  ?

• B60H 1/32 - Cooling devices
• B60P 3/20 - Vehicles adapted to transport, to carry or to comprise special loads or objects for transporting refrigerated goods

Abstract

A ball sports training method and a ball sports training system. The method comprises: during the process of a training object engaging in ball sports, acquiring a plurality of sports scene images collected by means of an image collection apparatus, and a collection time of each sports scene image; on the basis of the plurality of sports scene images and the collection time of each sports scene image, determining hitting response information of the training object, wherein the hitting response information comprises at least one of hitting implementation information, related-hitting-position information, hitting response time information and hitting speed information; and on the basis of the hitting response information, determining training assessment information for the training object, wherein the training assessment information comprises assessment information about the sports performance of the training object and/or assessment information about the physical health status of the training object. Therefore, the objectivity, accuracy, high efficiency and professionalism of ball sports training are improved, and the labor costs are reduced; and when the solution is applied to rehabilitation training, the effect of rehabilitation training can be significantly improved.

IPC Classes  ?

• A63B 67/04 - Table games physically beneficial for the human body, modelled on outdoor sports, e.g. table tennis

Abstract

A knee mounting device for providing TENS treatment is disclosed. The knee mounting device is coupled to a patient's knee to locate and stimulate ST-36 acupoint transcutaneously for treating or relieving osteoarthritic pain. The knee mounting device includes a lower assembly mountable onto a leg portion under a kneecap, an upper assembly mountable on a thigh, and a sleeve adapted to connect the upper and lower assemblies. The lower assembly contacts arranged for contacting the ST-36 acupoint, and thermal pad arranged for applying thermal treatment to an area proximate to the ST-36 acupoint. The upper assembly includes a pulse width modulation (PWM) generator configured to generate a pulse stimulation signal and couple the pulse stimulation signal to the contacts for stimulating the ST-36 acupoint. The sleeve is provided with a kneecap opening located to enwrap the patient's knee as anchor and place the contacts on top of the ST-36 acupoint.

IPC Classes  ?

• A61N 1/04 - Electrodes
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

Provided in the present application is an electromagnetic variable-damping lock-up type long-period vibration control device, comprising a housing, a rotating shaft, a pendulum mass, a braking assembly, a data acquisition element, an electromagnetic variable-damping module and a control module; the rotating shaft is rotationally connected to the housing; the pendulum mass is fixedly connected to the rotating shaft; the braking assembly is used for locking the rotating shaft; the data acquisition element is connected to the rotating shaft; the electromagnetic variable-damping module is connected to the rotating shaft; the control module is installed on the housing; the control module comprises a data processing unit and a controller, the data processing unit being electrically connected to the data acquisition element and being used for obtaining the angular velocity of the pendulum mass, and the controller being separately and electrically connected to the data processing unit, the braking assembly and the electromagnetic variable-damping module. In the present application, the electromagnetic variable-damping module adjusts the damping magnitude of the rotating shaft by means of changing the electromagnetic intensity, and the controller sets a lock-up duration on the basis of control algorithms so as to prolong the period of the device, thereby achieving better control over long-period and even ultra-long-period vibration.

IPC Classes  ?

• F16F 15/03 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system using electromagnetic means

Abstract

Disclosed in the present application is an energy management method for solar freezer trucks, the solar freezer truck includes a photo-voltaic (PV) module, a first battery, a freezer compressor, an engine generator, and an external power adapter connected by an energy management unit, and the energy management method includes obtaining an output power of the PV module; and switching, by the energy management unit, power paths to the freezer compressor according to the output power of the PV module.

IPC Classes  ?

• H02J 7/35 - Parallel operation in networks using both storage and other DC sources, e.g. providing buffering with light sensitive cells
• B60H 1/00 - Heating, cooling or ventilating devices
• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• H02J 7/14 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from dynamo-electric generators driven at varying speed, e.g. on vehicle
• H02J 7/34 - Parallel operation in networks using both storage and other DC sources, e.g. providing buffering

Abstract

The present application discloses an artificial reef device having a bionic coral texture structure and a reef module manufacturing method. The artificial reef device having the bionic coral texture structure comprises a main body (10) and a coral stopper module (20). The main body (10) is provided with first connecting structures (11), and the coral stopper module (20) is provided with a second connecting structure (21). The artificial reef device provided by the present application can be easily assembled underwater to form hollow structures of different sizes, providing habitat for various organisms. Additionally, the main body (10) and the coral stopper module (20) both have bionic coral texture structures, matching the natural environment of coral reefs, and conducive to the attachment and growth of marine organisms. The coral stopper module (20) is designed to facilitate coral inoculation in a laboratory, and can be connected to the main body (10) after inoculation. In addition, the artificial reef device is further provided with a biological filtering module (40) for placing oysters to optimize water quality by utilizing the filtering feeding characteristic of the oysters.

IPC Classes  ?

• A01K 61/73 - Artificial fishing banks or reefs assembled from components

Abstract

An energy management method and system, a computer device, and a readable storage medium. The energy management method comprises obtaining a first current output power and a previous output power of a first energy supply device; obtaining a current power change rate of the first energy supply device on the basis of the first current output power and the previous output power; obtaining a first reference power of the first energy supply device on the basis of the first current output power, the previous output power and the current power change rate; obtaining a second current output power of a second energy supply device; and obtaining a second reference power of the second energy supply device on the basis of the first current output power, the second current output power and the first reference power; obtaining a current flow velocity of a first gas, a current flow velocity of a second gas, and a current furnace temperature; and obtaining a reference flow velocity of the first gas and a reference furnace temperature on the basis of the current flow velocity of the first gas, the current flow velocity of the second gas, and the current furnace temperature.

IPC Classes  ?

• H01M 8/04537 - Electric variables

Abstract

A method of treating an object contaminated with or suspected of being contaminated with one or more microorganisms, the method comprising contacting the object with a compound such that the compound kills or inhibits the growth of at least a portion of the one or more microorganisms, wherein the compound has Formula 1: A method of treating an object contaminated with or suspected of being contaminated with one or more microorganisms, the method comprising contacting the object with a compound such that the compound kills or inhibits the growth of at least a portion of the one or more microorganisms, wherein the compound has Formula 1: or a pharmaceutically acceptable salt thereof, wherein: R1 is C4-C20 alkyl or C4-C20 alkene; and R2 is hydrogen, C1-C4 alkyl, or a side chain of a naturally occurring amino acid.

IPC Classes  ?

• A61K 31/223 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-amino acids
• A01N 31/14 - Ethers
• A01N 37/44 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio-analogue of a carboxylic group, e.g. amino-carboxylic acids
• A01N 47/30 - Derivatives containing the group N—CO—N—aryl or N—CS—N—aryl
• A01N 59/00 - Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/04 - Antibacterial agents

Abstract

Disclosed are an energy management method, system, computer device and readable storage medium. The method includes: obtaining a first current output power and a previous output power of a first energy supplier; obtaining a current power change rate of the first energy supplier according to the first current output power and the previous output power; obtaining a first reference power of the first energy supplier according to the first current output power, the previous output power and the current power change rate; obtaining a second current output power of a second energy supplier; obtaining a second reference power of the second energy supplier according to the first current output power, the second current output power and the first reference power; obtaining current flow rates of first and second gas and a current furnace temperature; and obtaining a reference flow rate of the first gas and a reference furnace temperature.

IPC Classes  ?

• B60L 58/40 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for controlling a combination of batteries and fuel cells
• B60L 1/12 - Methods or devices for control or regulation
• B60L 50/40 - Electric propulsion with power supplied within the vehicle using propulsion power supplied by capacitors
• B60L 50/75 - Electric propulsion with power supplied within the vehicle using propulsion power supplied by batteries or fuel cells using propulsion power supplied by both fuel cells and batteries
• B60L 58/12 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries responding to state of charge [SoC]
• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• H02J 7/34 - Parallel operation in networks using both storage and other DC sources, e.g. providing buffering

Abstract

The present application provides an ultrasonic transducer and a method for preparing the same. The ultrasonic transducer includes a substrate layer, a piezoelectric layer, and an acoustic matching layer laminated in sequence along the thickness direction; the piezoelectric layer includes a substrate, the substrate includes a wiring area and a plurality of piezoelectric array elements distributed in a matrix along the row direction and the column direction, and two adjacent piezoelectric array elements are bonded by an insulating adhesive, and the upper and lower surfaces of the piezoelectric array elements and the insulating adhesive are formed by a vacuum-plated electrode layer to form row and column strip electrodes, which can be formed by cutting and photolithography. The end of the first electrode layer is electrically connected to the first conductive element; the end of the second electrode layer is electrically connected to the second conductive element.

IPC Classes  ?

• G01N 29/24 - Probes
• B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals

Abstract

A method for reducing myopia progression. In particular, the method includes administering to a subject a compound represented by the following formula or a composition comprising an effective amount of the same: A method for reducing myopia progression. In particular, the method includes administering to a subject a compound represented by the following formula or a composition comprising an effective amount of the same: A method for reducing myopia progression. In particular, the method includes administering to a subject a compound represented by the following formula or a composition comprising an effective amount of the same: or a pharmaceutically accept salt thereof, in which the compound can target and inhibit catechol-O-methyltransferase, up-regulate retinal dopamine expression and change the choroidal thickness of a uvea of the subject, where an increase in choroidal thickness indicates a reduction in myopia progression.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61P 27/10 - Ophthalmic agents for accommodation disorders, e.g. myopia

Abstract

A method for reducing myopia progression. In particular, the method includes administering to a subject a compound represented by the following formula or a composition comprising an effective amount of the same formula (I) or a pharmaceutically accept salt thereof, in which the compound can target and inhibit catechol-O-methyltransferase, up-regulate retinal dopamine expression and change the choroidal thickness of a uvea of the subject, where an increase in choroidal thickness indicates a reduction in myopia progression.

IPC Classes  ?

• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61P 27/02 - Ophthalmic agents

Abstract

The disclosure provides a combination of one or more hydrolases and one or more anti-microorganism drugs, and a pharmaceutical composition or a kit comprising the combination. The disclosure also provides a method for treating a microorganism infection by using a therapeutically effective amount of the combination, pharmaceutical composition or kit. The combination of this disclosure is safer, and more economical, and can re-sensitize a drug against lots of bacteria at less dosage in clinical and avoid antimicrobial resistance to extend the lifespan of the drug.

IPC Classes  ?

• A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
• A61K 31/7135 - Compounds containing heavy metals
• A61P 31/04 - Antibacterial agents

Abstract

Provided herein are combination of one or more hydrolases and one or more anti-microorganism drugs, and a pharmaceutical composition or a kit comprising the combination. A method for treating a microorganism infection by using a therapeutically effective amount of the combination, pharmaceutical composition or kit is also provided. The combination is safer, and more economical, and can re-sensitize a drug against lots of bacteria at less dosage in clinical and avoid antimicrobial resistance to extend the lifespan of the drug.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 35/74 - Bacteria
• A61P 31/12 - Antivirals

Abstract

A prosthetic limb control method and a system. The prosthetic limb control method comprises: acquiring sensory feedback information and generating a stimulation signal on the basis of the sensory feedback information (102), the sensory feedback information referring to state information of a prosthetic limb being in a first state of contact after being in contact with an external object, the stimulation signal being used for stimulating stress tissue of an amputee, and the stress tissue comprising muscle tissue or nerve tissue corresponding to the prosthetic limb; acquiring stress information generated after the stress tissue receives the stimulation signal (103); and generating a control signal on the basis of the stress information, the control signal being used for dynamically controlling the prosthetic limb to switch from the first state of contact with the external object into a second state of contact (104). The method coordinately corrects the state of contact of prosthetic limbs with external objects on the basis of sensory feedback information, thereby improving the accuracy of control, flexibility and coordination for the prosthetic limbs, enabling the prosthetic limbs to achieve optimal adaptability and thus achieving the purpose of autonomy of amputees.

IPC Classes  ?

• A61F 2/68 - Operating or control means

Abstract

A method for ultrasound stimulation of spinal cord, the method comprising at least two stimulation cycles, each comprising the steps of: a) obtaining a first real-time spinal cord using a first set of ultrasound transducers; b) selecting a pre-determined stimulation area of the spinal cord from the first real-time spinal cord; c) calculating the position and orientation of the selected stimulation area relative to a second set of ultrasound transducers; and d) stimulating the selected stimulation area of the spinal cord at the calculated relative position and orientation using the second set of ultrasound transducers.

IPC Classes  ?

• A61N 7/00 - Ultrasound therapy
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells

Abstract

An ultrasound neuromodulation actuator including a stable hollow silica nanoparticle(HSN) structure, in particular, a PEGylated HSN(pHSN) particle, and a method for preparing the same. Provided are methods for enhancing ultrasound stimulation and treating neurological disorders of a subject including applying the pHSN particles to a brain region of the subject followed by ultrasound stimulation.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 25/08 - AntiepilepticsAnticonvulsants
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/24 - Antidepressants
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention provides an integrated system built on a microfluidics with multiple layers including a cell culture surface and different chambers configured to allow multiple cultivations of a biological agent, formation of three-dimensional multicellular culture model or biofilm, colonization and re-colonization of the biological agent responsive to a stimuli introduced to the integrated system. Such stimuli include physical, chemical and/or biological substance that may affect proliferation, differentiation, and/or function of the biological agent. The biological agent includes a biofilm-forming microbe such as a ubiquitous biofilm-forming bacterial species or biological cells or tissues of a different origin or species such as eukaryotic cells/tissues. The present integrated system can be used in drug screening, establishment of disease model in vitro or in vivo, evaluation of an anti-microbial efficacy, and studying cell-cell interaction.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/18 - Testing for antimicrobial activity of a material

Abstract

A smart textile (100), comprising first conductive yarn (101), thermochromic yarn (102) and polymer optical fibers (103), which are woven in a weft direction, wherein electrodes extending in a warp direction are respectively embroidered at two ends of the first conductive yarn (101); the first conductive yarn (101) is used for producing heat when the electrodes are energized, such that the temperature of the smart textile (100) changes; when the illumination intensity on a surface of the smart textile (100) is greater than a preset value, the thermochromic yarn (102) is configured to present different colors on the basis of the change in the temperature of the smart textile (100); two ends of the polymer optical fibers (103) are respectively gathered to form harnesses and are respectively connected to light source devices (1051, 1052); the polymer optical fibers (103) are configured for presenting the color of light emitted by the light source devices (1051, 1052); and the color of the light emitted by the light source devices (1051, 1052) is determined on the basis of the current temperature of the smart textile (100).

IPC Classes  ?

• D03D 15/533 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads antistaticWoven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads electrically conductive

Abstract

An integrated system built on a microfluidics with multiple layers includes a cell culture surface and different chambers configured to allow multiple cultivations of a biological agent, formation of three-dimensional multicellular culture model or biofilm, colonization and re-colonization of the biological agent responsive to a stimuli introduced to the integrated system. Such stimuli include physical, chemical and/or biological substance that may affect proliferation, differentiation, and/or function of the biological agent. The biological agent includes a biofilm-forming microbe such as a ubiquitous biofilm-forming bacterial species or biological cells or tissues of a different origin or species such as eukaryotic cells/tissues. The integrated system can be used in drug screening, establishment of disease model in vitro or in vivo, evaluation of an anti-microbial efficacy, and studying cell-cell interaction.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• A61P 31/04 - Antibacterial agents

Abstract

The present invention provides an ultrasound neuromodulation actuator including a stable hollow silica nanoparticle (HSN) structure, in particular, a PEGylated HSN (pHSN) particle, and a method for preparing the same. The present invention also provides methods for enhancing ultrasound stimulation and treating neurological disorders of a subject including applying the pHSN particles to a brain region of the subject followed by ultrasound stimulation.

IPC Classes  ?

• A61N 7/00 - Ultrasound therapy

Abstract

The present invention provides a compound or derivatives thereof capable of lowering circulating glucose in a subject. The compound is a recombinant placenta-specific protein 9 (Plac9) or derivatives thereof that can enhance glucose uptake by liver cells or hepatocytes in an insulin-independent manner, thereby lowering the circulating glucose. The present invention also provides a composition including an effective amount of the compound or derivatives thereof and a method for treating diseases or conditions associated with or arising from high circulating glucose such as diabetes mellitus.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

A rotary motion generator for helping a patient to relearn walking is disclosed. The knee exoskeleton device includes a rotary shaft, a moveable lever, and a first elastomeric structure. The rotary shaft is switchable between a one-way rotation mode and a two-way rotation mode in a sagittal plane, and locking the joint position by the one-way rotation mode. The moveable lever protrudes from an outer periphery of the rotary shaft perpendicularly for rotating the rotary shaft. The first elastomeric structure is pneumatically controlled for engaging the moveable lever for generating an output torque and producing the relative rotatory movement of a lower arm with respect to an upper arm. The rotary shaft further comprises a pawl, a second elastomeric structure for projecting or retracting the pawl, and a rotation locking mechanism that switches the rotary shaft between the one-way rotation mode and the two-way rotation mode.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

Method for preparing a doped metal phosphorus trichalcogenide (dMPT) comprising: (a) contacting a first metal salt, an optional base and a fluorine salt under hydrothermal conditions thereby growing a first metal precursor on a conductive substrate; (b) contacting the first metal precursor with an aqueous solution of a second metal salt thereby forming a doped metal precursor; and (c) contacting the doped metal precursor, phosphorus, and sulfur thereby forming a mixture; and heating the mixture;a dMPT, and a method for producing hydrogen gas using the same.

IPC Classes  ?

• C01B 25/08 - Other phosphides
• C01B 25/14 - Sulfur, selenium, or tellurium compounds of phosphorus
• B01J 27/185 - PhosphorusCompounds thereof with iron group metals or platinum group metals
• C25D 1/06 - Wholly-metallic mirrors

Abstract

Method for preparing a doped metal phosphorus trichalcogenide (dMPT) comprising: (a) contacting a first metal salt, an optional base and a fluorine salt under hydrothermal conditions thereby growing a first metal precursor on a conductive substrate; (b) contacting the first metal precursor with an aqueous solution of a second metal salt thereby forming a doped metal precursor; and (c) contacting the doped metal precursor, phosphorus, and sulfur thereby forming a mixture; and heating the mixture; a dMPT, and a method for producing hydrogen gas using the same.

IPC Classes  ?

• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C01B 25/14 - Sulfur, selenium, or tellurium compounds of phosphorus
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate

Abstract

A heat transfer device for applying a varying temperature to a portion of an animate body comprises a liquid conduit. The liquid conduit is liquidly connectable to an external first liquid source to establish a first circulation loop for transporting a first liquid. The liquid conduit is liquidly connectable to an external second liquid source to establish a second circulation loop for transporting a second liquid. The second liquid has a higher temperature than the first liquid. The liquid conduit is operably switchable between the first circulation loop and the second circulation loop for achieving the varying temperature applied to the portion of the animate body.

IPC Classes  ?

• A61F 7/02 - Compresses or poultices for effecting heating or cooling
• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

A method of reducing drug resistance of a cancer to an anticancer drug a subject in need thereof, the method including: administering a therapeutically effective amount of a compound to the subject, wherein the cancer overexpresses peroxiredoxin 1 (PRDX1) and the compound is a triazole linked flavonoid dimer. The anticancer drug can be doxorubicin, daunorubicin, vincristine, cisplatin, paclitaxel, mitoxantrone, and combinations thereof.

IPC Classes  ?

• A61K 31/4192 - 1,2,3-Triazoles
• C07D 311/30 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
• A61P 35/00 - Antineoplastic agents

Abstract

A leg shape intelligent recognition method and apparatus, an electronic device, and a storage medium, relating to the technical fields of human body measurement, garment fitness, and computer application. The method comprises: acquiring a key feature parameter value of a leg object to be identified (S102); and inputting the key feature parameter value into a trained support vector machine classification model to obtain a target leg shape category to which said leg object belongs and a circumference size category under the target leg shape category (S104).

IPC Classes  ?

• G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestriansBody parts, e.g. hands

Abstract

A ring focus spectacle lens (1) for controlling the progression of myopia, and a manufacturing method therefor. The ring focus spectacle lens (1) can provide clear vision for a patient, and also has a plurality of ring-shaped defocusing zones to provide an optical defocusing effect. Since there is no joint between successive concentric rings of different optical powers that are tangent to each other, the ring focus spectacle lens (1) is as aesthetic as a common spectacle lens. In the manufacturing method, three front mold cores (71), a rear mold core (72), and a planar rear mold core are used to manufacture a series of ring focus spectacle lenses (1) having different powers, thereby reducing the number of mold cores and the production cost. In addition, for the requirements of individuals with severe myopia and astigmatism, a semi-finished lens is provided by means of the manufacturing method, which not only greatly reduces the number of mold cores, but also reduces the inventory quantity of desired lenses, thereby reducing costs.

IPC Classes  ?

• G02C 7/06 - LensesLens systems bifocalLensesLens systems multifocal
• B29D 11/00 - Producing optical elements, e.g. lenses or prisms
• G02C 7/02 - LensesLens systems

Abstract

2 complex layer. In one embodiment, said method for manufacturing a perovskite with a modified surface, comprises the steps of: a) Providing a perovskite with a surface to be modified; b) Treating said surface to be modified with DPGABr; and c) Annealing to form said perovskite with a modified surface.

IPC Classes  ?

• H10K 30/50 - Photovoltaic [PV] devices
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3

Abstract

An ankle exoskeleton device for helping a patient to relearn walking by themselves is disclosed. The ankle exoskeleton device includes a leg brace, an insole, and a rotary actuator. The rotary actuator is pneumatically driven to cause rotation of the insole with respect to the leg brace about a central axis. The rotary actuator comprises first and second elastomeric structure, a rotary shaft rotatable about the central axis to generate an output torque for producing a relative rotatory movement of the insole, and a lever. the rotary shaft is adapted to be moved by controlling two opposing fluid pressures inside the rotary actuator. The first elastomeric structure is extendable to push the lever in a clockwise direction, and the second elastomeric structure is extendable to push the lever in an anticlockwise direction, thereby the first and second elastomeric structures are arranged to control the rotary shaft.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

The present application relates to the technical field of health-care foods and particularly relates to the use of tremella polysaccharides in preparing products for preventing and treating high-fat diet induced anxiety. It is found by researches in the present application that tremella polysaccharides can relieve the weight gaining of mice fed by high-fat diet, reduce the weights of the liver and fat, inhibit microglial cell activation and neuritis in the hippocampus, balance the intestinal flora, and have an excellent improvement effect on preventing and treating anxiety of mice caused by high-fat diet feeding. The present application verifies that tremella polysaccharides have the effect of preventing and treating high-fat diet induced anxiety and thus can be used to prepare products for preventing and treating high-fat diet induced anxiety. Therefore, as a nutritional intervention strategy for high-fat diet induced anxiety disorders, tremella polysaccharides are of great significance for assisting in preventing and relieving high-fat diet induced anxiety disorders.

IPC Classes  ?

• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A61P 25/22 - Anxiolytics
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates

Abstract

Embodiments of the present application are suitable for the technical field of ultrasonics, and provide a method and apparatus for generating a head ultrasound image, a terminal device, and a storage medium. The method comprises: in response to a start instruction, obtaining a head depth image of an individual to be checked, and on the basis of the head depth image, determining a plurality of sites to be checked; on the basis of a head feature value of each site to be checked, determining a first target site from among the plurality of sites to be checked; transmitting an ultrasonic signal to the first target site by means of a signal transmit unit, so as to generate a first head ultrasound image of the individual to be checked. According to the method provided in the embodiments of the present application, the terminal device can assist an ultrasonic operator in quickly and accurately finding a target site, thereby quickly obtaining a high-quality ultrasound image.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/14 - Echo-tomography
• A61B 8/06 - Measuring blood flow
• A61B 8/08 - Clinical applications
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

Provided are novel recombinant fusion proteins comprising asparaginase portion fused with an albumin-binding portion. The long-acting recombinant fusion proteins are able to deplete both asparagine and glutamine upon administration to a subject in need thereof, enabling these proteins to be used in the treatment of disease treatable by asparagine and/or glutamine depletion, such as gastric cancer, and food treatment.

IPC Classes  ?

• C12N 9/82 - Asparaginase
• C07K 19/00 - Hybrid peptides
• C07K 14/245 - Escherichia (G)
• C07K 14/27 - Erwinia (G)
• A61K 35/50 - PlacentaPlacental stem cellsAmniotic fluidAmnionAmniotic stem cells
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The present invention provides a method for storing digital data in proteins including: providing digital code that has been encoded from the digital data; assigning each of a plurality of amino acid residues with a specific binary sequence composed of at least three bits each selected from "0" or "1", where the plurality of amino acid residues is selected from at least eight different amino acid residues as data-bearing amino acid residues; translating the digital code into an amino acid sequence according to the specific binary sequence assigned to each of the amino acid residues; and synthesizing the one or more proteins each including a plurality of peptide segments, where each of the peptide segments includes no more than 30 amino acid residues and each of the proteins contains 100 to 2, 000 amino acid residues. The present invention also provides a method for retrieving digital data from the proteins.

IPC Classes  ?

• G16B 50/30 - Data warehousingComputing architectures

Abstract

The present application relates to the prevention and treatment of osteoarticular diseases, in particular osteoarthritis (OA), by inhibition of acetylcholinesterase (AChE). Specifically, this application provides a disease progression-modifying drug for the treatment of osteoarthritis, i.e., an acetylcholinesterase inhibitor, in particular a dimeric acetylcholinesterase inhibitor. The dimer targets both the enzymatic triad and non-enzymatic peripheral sites of acetylcholinesterase, thereby enhancing protection of articular cartilage and subchondral bone.

IPC Classes  ?

• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

The present disclosure relates to the technical field of artificial intelligence, and provides a head size measurement method and a 3D head grid generation method. According to the method, a face local area is determined by means of face feature points, a circular reference object is extracted from the face local area, and a head size of a target object is determined on the basis of the size of the circular reference object, thereby generating a 3D head grid. The accuracy is high.

IPC Classes  ?

• G06T 17/00 - 3D modelling for computer graphics

Abstract

A bionic finger (10), comprising: skin (100), an elastomer (200), a rigid supporting member (300) and a liquid delivery tube (400), wherein the skin (100) is provided with first liquid output holes (110); the elastomer (200) is wrapped and mounted in the skin (100), the elastomer (200) is provided with second liquid output holes (210), and the rigid supporting member (300) is wrapped and mounted in the skin (100); and a side portion of a first end (401) of the liquid delivery tube (400) is provided with third liquid output holes (410), the third liquid output holes (410), the second liquid output holes (210) and the first liquid output holes (110) are in communication with each other, and a second end (402) of the liquid delivery tube (400) extends to the outside of the skin (100). When the skin (100) of the bionic finger (10) comes into contact with a grabbed object, a liquid can flow from the second end (402) of the liquid delivery tube (400) located outside the skin (100) to the first end (401) of the liquid delivery tube (400) located inside the skin (100), and reaches a position between the skin (100) and the grabbed object sequentially through the third liquid output holes (410), the second liquid output holes (210) and the first liquid output holes (110), such that a friction coefficient between the bionic finger (10) and the grabbed object is changed, and thus a friction force between the bionic finger and the grabbed object is changed, thereby solving the technical problem of being unable to adjust the friction force with the bionic finger. Further provided are a fixture, and a manufacturing method for the bionic finger.

IPC Classes  ?

• B25J 15/00 - Gripping heads

Abstract

The present disclosure belongs to the technical fields of computers and defect detection. Provided are a defect detection method and a related device. The method comprises: obtaining an image to be processed; processing said image by means of a feature extraction module in a deep-learning defect detection model, wherein the feature extraction module comprises an intermediate feature layer, the intermediate feature layer comprises a dropout layer, and the dropout layer is configured to randomly drop features which are extracted by means of the intermediate feature layer processing said image, such that a plurality of features subjected to random dropout are obtained after said image is processed by means of the feature extraction module; by means of a detection head in the deep-learning defect detection model, processing the plurality of features subjected to random dropout, so as to obtain a plurality of category prediction results and a plurality of position prediction results of defects in said image; and obtaining category detection results, position detection results, category uncertainties and position uncertainties of the defects in said image according to the plurality of category prediction results and the plurality of position prediction results of the defects. (FIG. 1)

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

A method for certifying a Science, Technology, Engineering and Mathematics (STEM) industrial product is provided. Exemplarily, the method comprises: evaluating and scoring (831) a STEM literacy level acquirable by using the product to thereby yield a first score for STEM literacy; evaluating and scoring (832) product features findable in the product to thereby yield a second score for product features; evaluating and scoring (833) general abilities learnable after using the product to thereby yield a third score for general abilities; making (842) a final decision on a total score for the product according to the first, second and third scores; and awarding (843) the product with a certification level according to the total score of the product.

IPC Classes  ?

• G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]

Abstract

A transcranial sonography application device (100), comprising an annular guide rail (12), a first mounting frame (21), a first object-bearing platform (22) and a first detection assembly (3). The annular guide rail (12) is erected on the head of a user, the first mounting frame (21) is slidably connected to the annular guide rail (12) and is configured to drive the first object-bearing platform (22) to rotate around a circumferential direction of the head of the user, and the first detection assembly (3) is disposed on the first object-bearing platform (22) and is configured to scan the outer contour of the head of the user and determine the position of a cranial acoustic window. The transcranial sonography application device (100) can solve the technical problems in the prior art of high positioning difficulty and inaccurate positioning of the cranial acoustic window.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

A plate-to-roller imprinting apparatus capable of manufacturing a large-area micro/nano-structure (220) on an optical glass plate (100), and a method for processing the micro/nano-structure (220) on the optical glass plate (100). The plate-to-roller imprinting apparatus comprises a roller module (1) and a workpiece support module (2). The roller module (1) comprises a roller (11); the workpiece support module (2) comprises a workpiece table (21); the workpiece table (21) is arranged below the roller module (1); a core plate (22) is provided on top of the workpiece table (21); the micro/nano-structure (220) is provided on an upper surface of the core plate (22); and a heating device (3) is provided in the workpiece table (21), and the heating device (3) is located below the core plate (22); the optical glass plate (100) is arranged on the upper surface of the core plate (22); and the heating device (3) is used for heating the optical glass plate (100). The roller (11) rolls so that pressure can be applied to the optical glass plate (100), and one of the roller (11) and the workpiece table (21) can move in a reciprocating manner in a direction perpendicular to the central axis of the roller (11).

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G02B 3/00 - Simple or compound lenses

Abstract

A method of training a learning network to perform image segmentation includes receiving training data from a trusted source and an alternative source; assigning weights to data in the second corpus; dividing the data into batches with samples from the first and second corpuses; and completing training epochs by, for each batch: generating an output for each sample; determining a loss by comparing the generated output with a ground truth for each sample; defining a discrepancy for each second corpus sample as a difference between the sample loss and the average loss for the first corpus, approximated as the average loss for the first corpus from the preceding epoch modified by a change in the average loss from the preceding to the current epoch; identifying weights for the next batch which minimise the weighted sum of discrepancies and network parameters which minimise the average weighted loss.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation

Abstract

A method for certifying a Science, Technology, Engineering and Mathematics (STEM) industrial product is provided. The method comprises: evaluating and scoring a STEM literacy level acquirable by using the product to thereby yield a first score for STEM literacy; evaluating and scoring product features findable in the product to thereby yield a second score for product features; evaluating and scoring general abilities learnable after using the product to thereby yield a third score for general abilities; making a final decision on a total score for the product according to the first, second and third scores; and awarding the product with a certification level according to the total score of the product.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

Abstract

The present invention provides an isolated glucoregulatory compound having both insulinotropic and blood glucose lowering activities, a composition and uses thereof for treating diseases associated with insulin deficiency or failure in glucose uptake independent of insulin secretion by pancreatic cells such as hyperglycemia, type 1 diabetes, or type 2 diabetes mellitus in a subject.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention provides an intelligent adaptive wavefront measurement system for optical characterization. The system can obtain optical parameters of a sample to be measured. The system comprises a light source, a shearing generator, and a photoelectric coupling device which are sequentially arranged in the axial direction, wherein the shearing generator comprises a spatial light modulator and a phase difference micro-lens array which are sequentially arranged in the axial direction. In addition, the present invention further provides a corresponding method and a training method in a simulation environment, such that a machine learning-based adaptive technology is used for wavefront modulation of the spatial light modulator.

IPC Classes  ?

• G01J 9/02 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength by interferometric methods

Abstract

The present disclosure provides a font generation model training method and a related device. The method comprises: obtaining a sample text image of a reference font, description information of a target font and a target text image of the target font, wherein the sample text image and the target text image comprise the same text; inputting the sample text image of the reference font and the description information of the target font into a font generation model to be trained, so as to obtain a predicted text image of the target font; and according to the predicted text image of the target font and the target text image of the target font, training a generative adversarial network comprising the font generation model and a discrimination network, so as to obtain a trained font generation model.

IPC Classes  ?

• G06V 30/19 - Recognition using electronic means

Abstract

A wireless charging system for providing multi-frequency and multi-speed charging modes to transfer power wirelessly from a base device to a remote device is disclosed. The wireless charging system includes a split transmitter having a plurality of sub-transmitters; a split receiver having a plurality of sub-receiver; and a switched-capacitor circuitry comprising a plurality of switched-capacitor switches. The plurality of sub-receivers and the plurality of sub-transmitters each comprises co-planar induction coils of non-equal cross-sectional lengths positioned concentrically without an interception. The split transmitter and the switched-capacitor circuitry are controlled by a hybrid pulse width modulation (PWM) control method, and the split receiver is controlled by a model predictive control method.

IPC Classes  ?

• H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
• H01F 27/28 - CoilsWindingsConductive connections
• H01F 38/14 - Inductive couplings
• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type

Abstract

The present application is applicable to the technical field of data processing, and provides a psychological stress level detection method, apparatus and system. The method comprises: obtaining the number of micro-gestures, i.e., the frequency of micro-gestures, performed by a user within a first preset period; and inputting the frequency of micro-gestures into a stress level detection model to obtain the stress level grade of the user. According to the method provided by the present application, the stress level grade of the user is determined according to the frequency of micro-gestures performed by the user, so that the accuracy of detecting the stress level grade of the user can be improved. Moreover, compared with determining the stress level grade of the user by means of recorded sound data or image data, the method can reduce the risk of leaking user privacy, and has wider application scenarios.

IPC Classes  ?

• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

A multifunctional charging circuit includes: a first inverter circuit connected to a primary side winding of an isolation transformer and configured to convert a received first direct current into a first alternating current, then outputting it to the primary side winding; a first wireless charging coil, with one end connected to a corresponding end of a secondary side winding of the isolation transformer, and designed to receive electrical power wirelessly transmitted by a second wireless charging coil; a first resonance compensation circuit connected to the other end of the first wireless charging coil and the corresponding end of the secondary side winding, and configured to generate a resonance based on the electrical power received by the first wireless charging coil and/or the first alternating current received by the secondary side winding, subsequently outputting a first charging current to the rectifier circuit.

IPC Classes  ?

• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• H02J 7/06 - Regulation of the charging current or voltage using discharge tubes or semiconductor devices

Abstract

A multi-dimensional intelligent garment pressure test dress form apparatus and system, and a multi-dimensional intelligent garment pressure test method. The intelligent garment pressure test dress form apparatus comprises an apparatus main body and a human body model (2), wherein the human body model (2) is circumferentially segmented into a plurality of model units (21) around an axis; and the apparatus main body comprises a plurality of movable members (6) and a control base (1). Each movable member (6) is circumferentially distributed on the control base (1) around the center of a circle, and each movable member (6) is movably arranged in a straight line where a connecting line between the center of the movable member and the center of a circle is located; the model units (21) are respectively mounted on the movable members (6) on a one-to-one basis; and the control base (1) is used for driving the movable members (6) to move together or separately, so that multiple dimensions of the size and shape of the human body module (2) can be adjusted and changed. Therefore, when applied to a garment pressure test, the dress form apparatus can implement an intelligent, dynamic and shape-adjustable garment pressure test which includes a plurality of human body sizes, without frequently changing the human body module (2), thereby realizing economic and effective garment functionality measurement.

IPC Classes  ?

• A41H 5/01 - Dress formsBust formsStands with means for adjustment, e.g. of height

Abstract

The present application relates to the technical field of medicine. Provided is the use of integrin α5β1 as a target in the screening of drugs for preventing and/or treating bone loss. 8-isoprenyl flavone glycoside can replace a ligand fibronectin on cell surface receptor integrin α5β1, thereby achieving the binding of 8-isoprenyl flavone glycoside to the integrin α5β1, and thus improving the osteogenesis ability and the cell adhesion. Therefore, by using integrin α5β1 as a target of a drug for preventing and/or treating bone loss, and by means of the binding of 8-isoprenyl flavone glycoside to integrin α5β1, the activities of ALP, RhoA and Rac1 in bone marrow mesenchymal stem cells can be significantly improved, thereby promoting the osteogenesis and the cell adhesion, promoting the development of drugs for bone loss, and providing a new strategy and routine for the treatment of bone loss diseases.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

A gait event-driven, phase-dependent and multi-modal foot rehabilitation system, and a use method thereof. The system comprises: a pressure sensor module (110) which measures a pressure distribution value of a foot sole in real time; a micro-control module (111) which compares the measured pressure value with a preset threshold value to identify different gait events in a dynamic gait and a pressure balance on the inner and outer sides of the foot sole and to control a corresponding operation in real time; a neuromuscular electrical stimulation module (100) which applies or stops a suprathreshold electrical stimulation delivered to a target muscle of the foot on the basis of the recognized gait event; a combined pneumatic musculo-skeletal module (200) which comprises a pneumatic muscle (305) and deflates or inflates the pneumatic muscle (305) on the basis of the recognized gait event; and a vibratory biofeedback module (109) which, when recognizing an imbalance of pressure between the inner side and the outer side of the foot sole, provides a biofeedback to correct the imbalance of force exerted by the foot sole. The gait events comprises heel striking, heel off and sole off. The system can correct foot drop and foot varus, mitigate muscle compensation and dystrophy, and restore a normal gait.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes

Abstract

An immersive projection system (100) is installed in an immersive room (150).The immersive room (150) comprises a ceiling having an opening and a floor. The immersive projection system (100) comprises an image generator (110) which configured to render images to be displayed, a projection warping system (120) which configured to warp and blend rendered images received from the image generator (110), and a plurality of projectors (155) which configured to project images output from the projection warping system (120) into the immersive room (150). One of the plurality of projectors (155) is configured to project images onto the floor through the opening.

IPC Classes  ?

• G03B 21/00 - Projectors or projection-type viewersAccessories therefor

Abstract

An immersive projection system comprises an image generator configured to render images to be displayed; a projection warping system configured to warp and blend rendered images received from the image generator; an immersive room including ceiling having an opening and floor; and a plurality of projectors configured to project images output from the projection warping system into the immersive room; wherein, one of the plurality of projectors is configured to project images onto the floor through the opening.

IPC Classes  ?

• H04N 13/363 - Image reproducers using image projection screens
• H04N 9/31 - Projection devices for colour picture display

Abstract

A Hybrid Interactive Virtual Environment (HiVE) system and a method of use thereof are provided, said system and method are configured for clinical education and training. Said system comprising: an immersive room, which is 6-sided Cave Automatic Virtual Environment (CAVE) platform and is configured to a fully immersive interactive hybrid classroom; an image generator, which is configured to process input contents and render the input contents in either two dimensional (2D) mode or three dimensional (3D) mode to generate interactive contents for clinical education and training; a projection warping system to perform a process of projection warping and blending to generate a projection warped display image; and a video processing system to process the projection warped display image to generate a frame-synchronized display output; wherein the immersive room comprises a surround sound system to produce audio output to the interactive contents, a motion capture system to produce tracking information of the users inside the immersive room and send the tracking information to the interactive contents, and projectors to project the frame-synchronized display output from the video processing system to generate a 3D interactive image within the immersive room for clinical education and training, such that users in the immersive room may watch and listen to the 3D image and interact with the 3D image and/or with each other for clinical education and training.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

An Internet-based infectious disease prevention and control training system and an Internet-based infectious disease prevention and control training method. The system comprises a resource database, an application server, a network medium, and an application program on an intelligent terminal; the resource database comprises a service database and a user information database; the service database comprises texts, audios, images, short videos, and game controls; the application server comprises an access management module, a resource scheduling module, a report generation module, and a network optimization module; the access management module authenticates, on the basis of the user information database, login request information sent by a user; the resource scheduling module schedules the texts, the audios, the images, the short videos, or the game controls in the service database according to an instruction sent by the application program, and presents the texts, the audios, the images, the short videos, or the game controls to the intelligent terminal by means of the network medium; the application program comprises a plurality of themes associated with an infectious disease prevention and control standard file; and each theme is presented in the form of one or more games.

IPC Classes  ?

• G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
• G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
• G06Q 50/20 - Education
• G06F 16/245 - Query processing

Abstract

Methods for treating or preventing a skeletal sequelae of a coronavirus infection in a subject in need thereof, the method comprising administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide. The skeletal sequelae can include one or more of arthralgia, viral arthritis, osteopenia, osteochondral damage, and osteoporosis.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 19/00 - Drugs for skeletal disorders
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present application discloses a current collector and a manufacturing method therefor, an electrode sheet, a battery, and an electric device. The current collector comprises a dense carbon nanotube film layer and a metal layer bonded to the surface of the dense carbon nanotube film layer. Compared with a commercial metal foil, the weight of the current collector provided by the present application is only 15%-19% of that of the commercial metal foil, and the thickness of the current collector is 24%-32% of that of the commercial metal foil; moreover, the current collector has similar conductivity and electrochemical stability, and the mechanical strength and flexibility of the current collector are greatly improved. The mass specific energy density and the volume specific energy density of a battery using the current collector are respectively increased by 10.2%-25.7% and 5.1%-11.45%.

IPC Classes  ?

• H01M 4/66 - Selection of materials

Abstract

Provided herein are methods and compositions useful for treating bacterial cell populations including bacterial persister cells and/or antibiotic resistant bacterial cells.

IPC Classes  ?

• A61K 31/4174 - Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/04 - Antibacterial agents

Abstract

This invention provides an all-in-one device for virus diagnosis, especially for a target nucleic acid sequence or target antigens or anitbodies in a single sample, comprising: a sample chamber for holding a cuvette with a UCNP-based assay and said sample; a NIR light source; a sensor for measuring fluorescence emission from a UCNP-based assay comprising a light-to-frequency converter; Optics providing an optical path ensuring only fluorescence emission from said UCNP-based assay reaches said sensor; and a microcontroller; wherein said UCNP-based assay is a system comprising UCNP surface modified with a first oligo probe and AuNP surface modified with a second oligo probe, wherein said first oligo probe and said second oligo probe are independently complimentary to separate segments on said target nucleic acid sequence that are nearby each other; or/and a system comprising ligand-free UCNP with electrostatic attraction to said target protein and AuNR surface modified with antibodies for said target protein.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

A vision improvement module, comprising: a screen (1), an optical path folding lens assembly (2) and a zooming mechanism. The optical path folding lens assembly (2) is disposed on a light-emitting side of the screen (1), and the zooming mechanism is connected to the screen (1) or the optical path folding lens assembly (2). The vision improvement module changes the distance from the screen (1) to the nearest lens according to the degree of myopia of a user, so that the user is able to clearly see the screen (1) with the naked eye. On the basis of foregoing, an imaging position is continuously changed by means of the axial reciprocating motion of the screen (1) within a certain length range, or the optical path folding lens assembly (2) is adjusted by means of the zooming mechanism, so as to continuously change the focal length, thereby adjusting the activity of the ciliary muscles in the eyes, and finally improving myopia.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02C 7/08 - Auxiliary lensesArrangements for varying focal length

Abstract

A computer-implemented method for training a convolutional neural network (CNN) using training data comprising a pair of original and downsampled 4D magnetic resonance imaging (MRI) data is provided. The CNN is used to generate multi-parametric 4D magnetic resonance (MR) images based on multi-parametric 3D MR images in real-time. The method includes receiving a 4D MR image formed by a plurality of fixed images of different frames; converting the plurality of fixed images into a plurality of k-space data by non-uniform fast Fourier transform (NUFFT); applying radial scan to the k-space data to simulate real-time MR image acquisition, and generating a plurality of downsampled fixed images by inverse NUFFT; training a CNN with training data comprising the 4D MR image and the corresponding downsampled 4D MR image; and estimating the multi-parametric 4D MR image in real-time by applying apply the predicted DVF to the multi-parametric 3D MR images.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/48 - NMR imaging systems
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities
• G06T 7/00 - Image analysis

Abstract

Provided are a printing defect detection method and apparatus, and a device and a storage medium, which relate to the technical field of computers. The method comprises: acquiring an initial target image of a printed product to be subjected to detection; acquiring a reference image corresponding to said printed product; aligning the initial target image with the reference image in a plurality of modes, so as to respectively obtain a plurality of candidate transformed target images; determining a transformed target image on the basis of the degree of similarity between each of the plurality of candidate transformed target images and the reference image; performing color distribution feature standardization processing on the transformed target image on the basis of the reference image, so as to obtain a standardized transformed target image; and obtaining a final difference result on the basis of the standardized transformed target image and the reference image, so as to detect a printing defect of said printed product according to the final difference result.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

A permeable stretchable bioelectronic device with wafer-scale patterning capability including a stretchable and permeable substrate and one or more electronic components disposed on a surface of the substrate, wherein the stretchable and permeable substrate includes a biocompatible elastomeric fiber or a biocompatible hydrogel and the each of the one or more electronic components independently include a metal and a liquid metal and a method of fabrication thereof.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A multi-layered scaffold useful for osteochondral complex defects. The multi-layered scaffold can be prepared by photopolymerizing a multi-layer scaffold precursor including: a first layer disposed on a surface of a second layer, wherein the first layer includes a first tri-block poly(lactide-co-propylene glycol-co-lactide) dimethacrylate; and the second layer includes a second tri-block poly(lactide-co-propylene glycol-co-lactide) dimethacrylate, hydroxyapatite nanoparticles covalently conjugated to one or more hydroxyethyl methacrylate moieties via an optional linker, and a photoinitiator, wherein the nanoparticles comprise hydroxyapatite, tricalcium phosphate, silicon dioxide, bioglass, or a mixture thereof.

IPC Classes  ?

• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• A61K 38/18 - Growth factorsGrowth regulators
• A61L 24/02 - Surgical adhesives or cementsAdhesives for colostomy devices containing inorganic materials
• A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials

Abstract

A prosthetic hand device mountable on a residual limb of an amputee is provided. The prosthetic hand device includes a myoelectric hand having five mechanical fingers actuatable to provide multiple degrees of freedom of movement, a control assembly including an ultrasound module as a human-machine interface, wherein the ultrasound module is configured to acquire ultrasound images of a region of the residual limb, a transfer learning model having a convolutional neural network architecture for obtaining extracted features from the ultrasound images, and an artificial intelligence model executed by one or more processors and configured to classify the extracted features from the ultrasound images for determining a volitional movement of the amputee in real-time. The volitional movement is transmitted to the myoelectric hand to dynamically and proportionally control the five mechanical fingers based on at least the volitional movement.

IPC Classes  ?

• A61F 2/54 - Artificial arms or hands or parts thereof
• A61F 2/70 - Operating or control means electrical
• A61F 2/72 - Bioelectric control, e.g. myoelectric

Abstract

A prosthetic hand device mountable on a residual limb of an amputee is provided. The prosthetic hand device includes a myoelectric hand having five mechanical fingers actuatable to provide multiple degrees of freedom of movement, a control assembly including an ultrasound module as a human-machine interface, wherein the ultrasound module is configured to acquire ultrasound images of a region of the residual limb, a transfer learning model having a convolutional neural network architecture for obtaining extracted features from the ultrasound images, and an artificial intelligence model executed by one or more processors and configured to classify the extracted features from the ultrasound images for determining a volitional movement of the amputee in real-time. The volitional movement is transmitted to the myoelectric hand to dynamically and proportionally control the five mechanical fingers based on at least the volitional movement.

IPC Classes  ?

• A61F 2/70 - Operating or control means electrical
• A61F 2/58 - ElbowsWrists
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition

Abstract

A method of treating a coronavirus infection in a subject in need thereof, the method including administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61P 31/14 - Antivirals for RNA viruses
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

A data processing method and apparatus. The method comprises: a first device acquires first data, and inputs the first data into a trained task model to obtain a processing result output by the task model, wherein the task model comprises a pre-trained model and at least one prompt module, the pre-trained model is divided into a plurality of modules, and every two adjacent modules among the plurality of modules correspond to one of the at least one prompt module; and input data of a first module arranged at a start position among the plurality of modules comprises first data, and input data of any second module arranged behind the first module among the plurality of modules is determined according to a processing result output by a module previous to the second module and a correction factor output by a target prompt module. According to the method, on the basis that the structure of a pre-trained model is not changed, a correction factor is used to better stimulate the pre-trained model to migrate pre-training knowledge so as to perform pixel-level semantic annotation, thereby improving task processing precision.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

A method of preparing core-shell nanoparticles, the method comprising: contacting a mixture comprising a first metal oxide, a first encapsulating material comprising an alkali metal or alkaline earth metal, and a second encapsulating material comprising a second metal oxide with hydrogen gas at a temperature higher than the hydrogen reduction temperature of the first metal oxide and lower than the decomposition temperature of the first encapsulating material resulting in the reduction the first metal oxide and the formation of metal nanoparticles that are at least partially encapsulated with a bimetallic oxide comprising the alkali metal or the alkaline earth metal and the second metal oxide thereby forming the core-shell nanoparticles, wherein the Tammann temperature of the first encapsulating material is lower than the hydrogen reduction temperature of the first metal oxide.

IPC Classes  ?

• B01J 37/02 - Impregnation, coating or precipitation
• B01J 21/04 - Alumina
• B01J 23/76 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups

Abstract

The present disclosure provides an ultrathin and superlight glass-fiber based current collector enabling energy-dense flexible batteries, and a method for fabricating the current collector. This current collector includes a metal-coated glass-fiber fabric having metal-coated glass fibers, and the metal-coated glass fiber includes a surface-modified glass fiber covered by one or two metal layers.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/04 - Processes of manufacture in general
• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/74 - Meshes or woven materialExpanded metal
• H01M 50/141 - Primary casingsJackets or wrappings for protecting against damage caused by external factors for protecting against humidity
• H01M 50/491 - Porosity

Abstract

Provided are an optical fiber sensor and a magnetic field strength measuring apparatus. The optical fiber sensor comprises an optical fiber (2) and a magnetic component (1). At least one optical fiber (2) is provided. The optical fiber (2) extends in a preset direction. A preset position is provided in the extension length of the optical fiber (2), and a Bragg grating (21) is formed at the preset position. The magnetic component (1) is connected to the preset position of the optical fiber (2). The magnetic component (1) can generate a position offset under the action of magnetic force, so as to allow the Bragg grating (21) at the preset position to produce a bending deformation perpendicular to the preset direction. The magnetic field strength measuring apparatus comprises the optical fiber sensor. The optical fiber sensor aims to solve the technical problem of inaccurate magnetic field strength measurements caused by the use of a current-carrying conductor, which is susceptible to electromagnetic and radio frequency interference.

IPC Classes  ?

• G01R 15/24 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using light-modulating devices
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables
• G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday

Abstract

Cyclic 1,4,7-triazacyclononane-1,4,7-triacetic acid chelators and metal complexes comprising the same useful as positron emission tomography imaging agents, magnetic resonance imaging contrast agents, and computed tomography imaging agents, and optical imaging agents, and methods of use and preparation thereof.

IPC Classes  ?

• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 51/04 - Organic compounds
• C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

The present invention provides an integrated microfluidic-based device for establishing a wound infection in vivo model suitable for high throughput bioassay such as potential drug screening, in vivo dosing optimization, host-microbe or microbe-microbe interactions under the influence of specific agents of interest, and studying regulatory mechanisms of certain inflammatory diseases relating to or arising from the wound infection. The present invention allows direct qualitative and quantitative assessments of specific markers expressed due to the wound infection by one or more microbes devoid of cell sorting, isolation, or labelling as in other conventional in vivo models or methods.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A head-mount transcutaneous electrical nerve stimulation (TENS) device adapted to stimulate acupoints of a user transcutaneously when being worn on the head of the user is disclosed. The TENS device includes one or more frames, a plurality of contacts, a pulse width modulation (PWM) generator, and one or more thermal pads. The one or more frames are arranged to have a contour matching an anatomical shape of the head. The plurality of contacts is arranged on an inner surface of the one or more frames for contacting the acupoints on the head. The PWM generator is configured to generate a pulse stimulation signal and couple the pulse stimulation signal to the plurality of contacts for stimulating the acupoints. The one or more thermal pads are arranged on the inner surface of the one or more frames for applying thermal treatment to the acupoints.

IPC Classes  ?

• A61N 1/04 - Electrodes
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

In generating training and testing datasets for machine learning, manual annotation of a large volume of data is impractical and expensive. A machine-learning model for detecting carcinoma (CA) from a whole slide image (WSI) processes average cellular features of cells identified on the WSI. Each cellular feature is a descriptive statistic of the cells, advantageously allowing the training and testing datasets to be constructed without a costly annotation process of pixelwise labelling each cell on a WSI training sample. Apart from predicting a CA case or a non-CA case for the WSI, the machine-learning model is also usable to: identify a suspicious CA case for priority assessment if a non-CA case is predicted for the WSI; generate a tumor probability heatmap of the WSI for visualizing potential CA regions on the WSI to assist pathological assessment; and assess quality control of a triage system before implementation in clinical setting.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Provided are an installation auxiliary tool for blind bolts, an installation kit and a use method therefor. The installation auxiliary tool for blind bolts (100) comprises a clamping assembly (10), a connection assembly (20), an elastic member (60) and a force transmission member (50). The clamping assembly (10) comprises two clamping arms (11), the two clamping arms (11) being arranged opposite to each other in a spaced-apart manner, and one end of each clamping arm (11) being a clamping end (111). Two ends of the connection assembly (20) are respectively and rotatably connected to the two clamping arms (11). Two ends of the elastic member (60) are respectively connected to the two clamping arms (11), and are used for driving the clamping ends (111) of the two clamping arms (11) to approach each other. The force transmission member (50) is located between the two clamping arms (11) and is in threaded connection with the connection assembly (20). The installation kit comprises a blind bolt (100) and said installation auxiliary tool, said installation auxiliary tool being used for assisting in installing the blind bolt (100). During use of the said installation auxiliary tool, the force transmission member (50) is rotated to convert the torque of the force transmission member (50) into an axial force, so as to easily push the blind bolt (100) to pass through an installation hole, thus effectively reducing physical exertion of operators, and helping to reduce the workload of the operators.

IPC Classes  ?

• B25B 27/14 - Hand tools or bench devices, specially adapted for fitting together or separating parts or objects whether or not involving some deformation, not otherwise provided for for assembling objects other than by press fit or detaching same
• F16B 13/06 - Dowels or other devices fastened in walls or the like by inserting them in holes made therein for that purpose with parts gripping in the hole or behind the reverse side of the wall after inserting from the front combined with expanding sleeve

Abstract

The present disclosure provides a system and method for precision tumor delineation in cancer treatment or diagnosis for subjects with carcinoma, in particular, nasopharyngeal carcinoma, based on contrast agent-free, virtual contrast-enhanced MRI data (VCE-MRI) synthesized by a modified multimodality-guided synergistic neural network trained with a more diversified training dataset and having a higher generalizability by minimizing data distribution variation between an external dataset and the training dataset through a data distribution matching mechanism before VCE-MRI synthesis.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06T 7/00 - Image analysis

Abstract

The present application relates to the technical field of 3D materials, and in particular, to a composite 3D printing material containing tea residues, a preparation method therefor and a use thereof. The provided composite 3D printing material containing tea residues comprises the following components in percentage by weight: 70-95% of a resin matrix and 5-30% of tea residues. It is ensured that the obtained composite 3D printing material has high tensile strength and maintains certain toughness, so that the composite 3D printing material containing tea residues can well meet the relevant technical requirements of FDM 3D printing, and realize a high printing success rate during the FDM 3D printing. Therefore, the provided composite 3D printing material containing tea residues achieves high value-added recycling of the tea residues, and is beneficial to environmental protection and cost reduction; additionally, the provided composite 3D printing material containing tea residues can better meet the functional requirements of routine 3D printing, and printed products have excellent comprehensive performance and a wide range of applications.

IPC Classes  ?

• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C08L 55/02 - ABS [Acrylonitrile-Butadiene-Styrene] polymers
• B33Y 70/00 - Materials specially adapted for additive manufacturing

Abstract

A novel pharmacologic treatment of refractive disorders including myopia and hyperopia is provided. The method of treating refractive disorders including myopia and hyperopia is mainly through targeting the Hippo biological pathway using agonists, antagonists or gene therapy targeting the HIPPO signaling, including MST1/MST2, LATS1/LATS2 kinases, and YAP/TAZ proteins. It is also found that the drug XMU-MP-1, a reversible and selective inhibitor of MST1/2, is a promising drug to target the Hippo biological pathway.

IPC Classes  ?

• A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
• A61P 27/02 - Ophthalmic agents
• A61P 27/10 - Ophthalmic agents for accommodation disorders, e.g. myopia

Abstract

In an indoor environment on fire, automatic deployment of sensors disposed on, beneath or over the floor to look upward the ceiling to observe a body of smoke and flame risen near the ceiling allows important information regarding states and dynamics of the body of smoke and flame to be gathered at an early stage of fire (e.g. before arrival of firefighters). By distributing the sensors over the indoor environment, the states and dynamics of the body of smoke and flame are monitored holistically (i.e. as a whole) even at the early stage of fire. Such information is useful to predict development of the fire. In one implementation, a sensor is held in an infrastructure sensor holder mounted on the ceiling during normal time. Upon detecting occurrence of fire, the sensor drops from the holder to land on the floor and orients a sensing direction vertically upward to perform monitoring.

IPC Classes  ?

• G01K 3/14 - Thermometers giving results other than momentary value of temperature giving differences of valuesThermometers giving results other than momentary value of temperature giving differentiated values in respect of space
• A62C 3/00 - Fire prevention, containment or extinguishing specially adapted for particular objects or places
• A62C 99/00 - Subject matter not provided for in other groups of this subclass
• G01K 13/00 - Thermometers specially adapted for specific purposes
• H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom

Abstract

A piezoelectric-photovoltaic integrated apparatus, a preparation method, and an application. The piezoelectric-photovoltaic integrated apparatus comprises a piezoelectric assembly and a photovoltaic assembly, wherein the piezoelectric assembly comprises a first piezoelectric electrode, a piezoelectric active layer and a second piezoelectric electrode; the photovoltaic assembly comprises a first photovoltaic electrode, a photovoltaic active layer, a hole transport layer and a second photovoltaic electrode; and in the direction from an outer layer to an inner layer, the second photovoltaic electrode, the hole transport layer, the photovoltaic active layer, the first photovoltaic electrode, the second piezoelectric electrode, the piezoelectric active layer and the first piezoelectric electrode are sequentially arranged in a cladding manner. A piezoelectric assembly and a photovoltaic assembly are integrated, thereby solving the problems in the prior art of a photovoltaic conversion device and a piezoelectric conversion device having the defect of intermittent power supply, and thus the application scenarios being limited. A two-dimensional/three-dimensional tin-based perovskite material is used for a photovoltaic active layer, so that the photovoltaic conversion efficiency is high, the properties are stable, and minor harm is caused. The apparatus can be widely applied to fabrics, wearable devices, mobile devices and sensors.

IPC Classes  ?

• H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors

Abstract

The present application provides a composite wrapped steel bar and a manufacturing method therefor, an on-site bending method, and an application. The composite wrapped steel bar comprises a steel bar of a core portion and a composite protection layer wrapped around the surface of the steel bar. The composite wrapped steel bar of the present application has the characteristics of corrosion resistance, impact resistance, peeling resistance, good bonding performance with concrete, and a price–performance ratio, etc. A concrete structure is enhanced by using the composite wrapped steel bar provided by the present application, so that the durability of the structure can be significantly improved, and the service life of the structure can be prolonged. The composite wrapped steel bar provided by the present application is suitable for infrastructure construction in corrosive environments, for concrete structures obtained by directly mixing sea water and sea sand, and for the construction of offshore islands and reefs having national defense and economic value.

IPC Classes  ?

• E04C 5/01 - Reinforcing elements of metal, e.g. with non-structural coatings

Abstract

Provided is a microbial system established based on a genetically modified bacterial strain under a genus of Pseudomonas with improved capacities to form more biofilms and trap more microplastics from a source than its wild-type form. In particular, the genetically modified bacterial strain is selected from P. aeruginosa, and the genetically modified P. aeruginosa is provided by adaptive mutation to a gene responsible for regulating an adhesion protein expression in an exopolymeric matrix of the biofilms. A method for recovering the microplastics trapped by the biofilms of this genetically modified bacterial strain is also provided.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C12R 1/385 - Pseudomonas aeruginosa

Abstract

Embodiments of the present disclosure provide a fuel cell power generation device, which includes: a fuel cell with an anode and a cathode, for decomposing hydrogen and generating electric energy through reaction of decomposed hydrogen and oxygen; a first delivery pipe connected between a pipeline of a hydrogen-containing gas and the fuel cell, for delivering the hydrogen-containing gas to the anode of the fuel cell; a first output pipe connected to the fuel cell, for discharging a first remaining gas contacted with the anode of the fuel cell; a second delivery pipe connected to the fuel cell, for delivering an oxygen-containing gas to the cathode of the fuel cell; and a second output pipe connected to the fuel cell, for discharging a second remaining gas contacted with the cathode of the fuel cell.

IPC Classes  ?

• H01M 8/04082 - Arrangements for control of reactant parameters, e.g. pressure or concentration
• H01M 8/04007 - Auxiliary arrangements, e.g. for control of pressure or for circulation of fluids related to heat exchange
• H01M 8/04089 - Arrangements for control of reactant parameters, e.g. pressure or concentration of gaseous reactants
• H01M 8/04746 - PressureFlow
• H01M 8/0662 - Treatment of gaseous reactants or gaseous residues, e.g. cleaning
• H01M 16/00 - Structural combinations of different types of electrochemical generators

Abstract

Sustainable upcycling method of preparing an electrocatalyst, the method including: providing an electrode material obtained from a lithium-ion battery, wherein the electrode material includes LiFePO4@N-doped carbon core-shell particles; contacting the electrode material with an aqueous solution comprising an acid thereby forming the electrocatalyst; and optionally drying the electrocatalyst.

IPC Classes  ?

• C01B 25/37 - Phosphates of heavy metals
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

Provided is use of Cs4-SeNPs in preparing a product for resisting neurodegeneration diseases such as Parkinson's disease.

IPC Classes  ?

• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 25/16 - Anti-Parkinson drugs

Abstract

44@N-doped carbon core-shell particles; contacting the electrode material with an aqueous solution comprising an acid thereby forming the electrocatalyst; and optionally drying the electrocatalyst.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• H01M 4/88 - Processes of manufacture
• H01M 4/90 - Selection of catalytic material
• H01M 12/08 - Hybrid cellsManufacture thereof composed of a half-cell of a fuel-cell type and a half-cell of the secondary-cell type

Abstract

The present invention provides a method for treating non-alcoholic fatty liver disease (NAFLD), associated conditions and symptoms. In particular, the method includes administering to a subject suffering from or susceptible to NAFLD a composition including therapeutic nucleic acids to reduce G protein-coupled receptor 110 (GPR110) expression in liver. The present invention also provides a pharmaceutical composition for treating NALFD or alleviating conditions and symptoms associated therewith.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics