Abstract

A Miller clamping circuit for driving a wide bandgap (WBG) device is provided. The Miller clamping circuit comprises: a semiconductor switching device having high side terminal connected to gate of the WBG device; and low side terminal connected to source of the WBG device; a first diode having anode connected to ground terminal of a driver IC chip; and cathode connected to control terminal of the switching device; a first resistor connected in parallel with the first diode; a second resistor having a first end connected to the ground of the driver IC chip; a second diode having anode connected to the low side terminal of the switching device and cathode connected to a second end of the second resistor; and a third resistor connected in parallel with the second diode. The Miller clamping circuit is configured to suppress a false turn-on and gate-loop oscillation of the WBG device simultaneously.

IPC Classes  ?

• H03K 17/30 - Modifications for providing a predetermined threshold before switching
• H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors

Abstract

An AI-based event grounding system is provided. The event grounding system includes an input device, an output device, a graphic processing unit (GPU); and a processor. The processor connects the input device, the output device, and the GPU. The event grounding system receives a free-text through the input device, and the processor perform an event grounding to the free-text through the GPU. The GPU performs event acquisition from the free-text using semantic parsing and acquires a plurality of verb-centric events, and performs event abstraction and acquires a plurality of abstract events, and grounds the abstract events to a plurality of anchor events of an event-centric KG, and reasons a subgraph through a reasoning model, and the subgraph includes the abstract events and the anchor events. The GPU generates a prediction based on the reasoning and provide the prediction through the processor and the output device.

IPC Classes  ?

• G06F 40/30 - Semantic analysis
• G06F 40/205 - Parsing
• G06F 40/253 - Grammatical analysisStyle critique
• G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates
• G06N 5/04 - Inference or reasoning models

Abstract

A system includes a measurement module, an industrial I/O expansion module, an SBC module, and a user interface module. The measurement module provides a platform for connecting a PV panel module for current and voltage measurement. The measurement module comprises a voltage sensor, a current sensor, and a MOSFET. The PV panel module and the current sensor are connected in series, and a series combination of the PV panel module and the current sensor is connected in parallel with the voltage sensor as well as the MOSFET. The industrial I/O expansion module is coupled with the measurement module for conversion of analog signals to digital signals. The SBC module obtains current and voltage readings from the measurement module via the industrial I/O expansion module. The user interface module is coupled with the SBC module and provides a user interface, allowing users to operate a measurement process.

IPC Classes  ?

• H02S 50/10 - Testing of PV devices, e.g. of PV modules or single PV cells
• G01R 19/165 - Indicating that current or voltage is either above or below a predetermined value or within or outside a predetermined range of values
• H02S 40/30 - Electrical components

Abstract

A method and a system for automatic evaluation of online debate arguments are provided. The method includes: defining multiple persona knowledge dimensions; tailor-making a prompt template according to the defined persona knowledge dimensions to generate a persona knowledge eliciting prompt; inputting the persona knowledge eliciting prompt to a pretrained language model to elicit persona knowledge; associating the elicited persona knowledge and the context and argument in the prompt to construct a knowledge-aligned prompt; and utilizing the knowledge-aligned prompt to fine-tune a debate evaluation model to evaluate persuasiveness/impact of the online debate arguments. The present invention can be applied to digital platforms equipped with tools to facilitate virtual discussions, incorporating features such as real-time feedback, interactive interfaces, and enhanced accessibility options to improve the overall debate experience, expand the range of platform participants, and thus make debates easier to understand and more attractive.

IPC Classes  ?

• G06F 40/40 - Processing or translation of natural language
• G06F 40/35 - Discourse or dialogue representation

Abstract

A light emitting device (LED) comprises a substrate, an anode layer disposed on the substrate, a hole injection layer disposed on the anode layer, a hole transport layer disposed on the hole injection layer, an emitting layer disposed on the hole transport layer, an electron transport layer disposed on the emitting layer, and a cathode layer disposed on the electron transport layer. At least one of the anode layer and the cathode layer is transparent. The emitting layer comprises a mixture of luminescent nanoparticles and an insulating material.

IPC Classes  ?

• H10K 50/115 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising active inorganic nanostructures, e.g. luminescent quantum dots
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• H10K 50/18 - Carrier blocking layers
• H10K 85/10 - Organic polymers or oligomers

Abstract

The subject invention pertains to a long-term antigen depot that can bypass FBR and engage DCs to mature and migrate to lymph nodes to activate antigen-specific T-cell activations. Leveraging on the immunomodulatory properties of exogenous polysaccharides and the anti-fouling characteristics of zwitterionic phosphorylcholine (PC) polymer, the invention features a PC functionalized dextran (PCDX) hydrogel for long-term antigen delivery. PCDX in both injectable scaffold and microparticles (MPs) forms effectively evades FBR and provides slow release of antigens resulting in local enrichment of CD11c+ DCs at the MPs injection sites. DC cultured on PCDX exhibits strong immunogenic activation with high CD86, CD40, MHC-I/peptide complex. PCDX also generates DC with propensity in migration to lymph nodes, as well as antigen presentation to trigger both CD4+ and CD8+ arms of T-cell responses. Besides cellular responses, PCDX can also induce potent humoral responses, with high levels of antigen specific IgG1 and IgG2a by day 28. Overall, PCDX provides long-term delivery of antigens for vaccine development.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/06 - OintmentsBases therefor
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61P 37/04 - Immunostimulants
• C08B 37/02 - DextranDerivatives thereof

Abstract

A system using global and local-aware denoising framework for commonsense knowledge graph noise detection is provided. The system includes an input receiver, a triple encoder, a global noise detector, a local noise detector, and a comprehensive evaluation scorer. The triple encoder receives the CSKG information from the input receiver and extract semantic information from free-text formatted nodes in the CSKG information, so as to obtain structured triples. The global noise detector identifies high-frequency patterns through rule mining and uses a rule encoder to generalize learned rules and guide noise detection. The local noise detector utilizes the structured triples output by the triple encoder to aggregate neighboring triple information around both the head and tail nodes via graph networks. The comprehensive evaluation scorer provides a comprehensive score based on global noise detection and local noise detection, so as to indicate a noise level for the CSKG information.

IPC Classes  ?

• G06F 40/157 - Transformation using dictionaries or tables
• G06F 40/30 - Semantic analysis

Abstract

Provided herein is a method of improved commonsense knowledge bases reasoning through constraint-based prompting. A novel dual-module constraint-based prompt engineering system named ConstraintChecker is involved, which employs a first rule-based module to produce a list of constraints and a second zero-shot learning module to check whether the knowledge instance satisfies all constraints. The acquired constraint-checking result is then aggregated with the output of the main prompting backbone to produce the final output. This present method is more effective in commonsense knowledge bases reasoning then that by employing the prompting backbone alone, and also significantly reduces computational costs.

IPC Classes  ?

• G06N 5/04 - Inference or reasoning models

Abstract

Provided herein is a novel method named Knowledge-Constrained Tree Search Decoding (KCTS) is provided, which is a first discriminator-guided constrained decoding approach to knowledge-grounded generation. The KCTS method also employs a Monte-Carlo Tree Search decoding (MCTS) instead of conventional LM decoding methods, which re-orders each token's importance based on the estimated future faithfulness starting from that token with multiple simulations. Coupled with a novel token-level hallucination detection method, RIPA (Reward Inflection Point Approximation), trained to predict the starting point of the hallucinating token, enabling effective adaptation of the knowledge classifier defined on the sequence level to the token level, this novel method is able to greatly mitigate hallucination problems of LLMs without the need of fine-tuning, thereby preventing the incurrence of high computational costs.

IPC Classes  ?

• G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates

Abstract

A cascode semiconductor device comprise a normally-on high-voltage (HV) silicon carbide (SiC) junction field-effect transistor (JFET), a normally-off low-voltage (LV) gallium nitride (GaN) high-electron-mobility transistor (HEMT) and a clamping circuit. The SiC JFET has a first gate terminal, a first drain terminal and a first source terminal. The GaN HEMT has a second gate terminal, a second drain terminal and a second source terminal. The second drain terminal is connected to the first source terminal. The second source terminal is connected to the first gate terminal. The clamping circuit is connected between the second drain terminal and the second gate terminal and has a clamping voltage. The clamping voltage is greater than a magnitude of a threshold voltage of the SiC JFET and smaller than a reverse gate voltage limit of the SiC JFET.

IPC Classes  ?

• H01L 27/088 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate
• H01L 27/06 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including a plurality of individual components in a non-repetitive configuration
• H03K 17/0412 - Modifications for accelerating switching without feedback from the output circuit to the control circuit by measures taken in the control circuit
• H03K 17/0814 - Modifications for protecting switching circuit against overcurrent or overvoltage without feedback from the output circuit to the control circuit by measures taken in the output circuit
• H03K 17/16 - Modifications for eliminating interference voltages or currents

Abstract

A tetrachromatic perovskite image sensor includes a quartz layer, two perovskite p-i-n-i-p components, and two optical transparent electrodes. The first perovskite p-i-n-i-p component, on one side of the quartz layer, detects ultraviolet and blue light, with two photodetection layers corresponding to detection to ultraviolet and blue wavelength intervals. The second component, on the opposite side, detects green and red light, with layers for detecting green and red wavelength intervals. Optical transparent electrodes on both sides of the quartz layer apply bias collectively to both perovskite p-i-n-i-p components.

IPC Classes  ?

• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 39/32 - Organic image sensors

Abstract

A lipophilic anchor includes a conjugation domain linked via a linker domain to an anchor domain having a plurality of hydrophobic tails. This lipophilic anchor allows deposition of at least one lipophilic target molecule with affinity for the anchor domain on a hydrophilic surface conjugated to the conjugation domain. The lipophilic target molecule coated hydrophilic substrate has the conjugation domain of the lipophilic anchor bound to the hydrophilic surface of a substrate and lipophilic target molecules are non-covalently bound to the anchor domain.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

Europium doped tin perovskites useful in the fabrication of optoelectronic devices exhibiting improved stability and high-power conversion efficiencies and perovskite precursor solutions used to prepare the europium doped tin perovskite, wherein the europium doped tin perovskite can be represented by Formula 1: Europium doped tin perovskites useful in the fabrication of optoelectronic devices exhibiting improved stability and high-power conversion efficiencies and perovskite precursor solutions used to prepare the europium doped tin perovskite, wherein the europium doped tin perovskite can be represented by Formula 1: (A+)(Sn2+)(X−)3·m[(Eu2+)(Y−)2]  1 wherein m is 0.001-0.05; X− for each instance is independently F−, Cl−, Br−, or I−; Y− for each instance is independently F−, Cl−, Br−, or I−; and A+ is Cs+, Rb+, CH3NH3+, CH3CH2NH3+, H(C═NH2)NH2+, Me(C═NH2)NH2+, or a mixture thereof.

IPC Classes  ?

• H10K 71/30 - Doping active layers, e.g. electron transporting layers
• C07F 19/00 - Metal compounds according to more than one of main groups
• H10K 30/30 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising bulk heterojunctions, e.g. interpenetrating networks of donor and acceptor material domains
• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/50 - Photovoltaic [PV] devices
• H10K 71/15 - Deposition of organic active material using liquid deposition, e.g. spin coating characterised by the solvent used
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3

Abstract

Single atom catalysts (SACs) are efficient electrocatalysts for catalyzing the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in lithium-oxygen batteries (LOBs). Our method is to study the origin of reactivity for a series of 17 transition metals supported on nitrogen-doped graphene, denoted SACs using Quantum Mechanics methods. Based on Gibbs free energy calculations, Zn-SAC performs the highest electrochemical activity among 17 SACs investigated. Machine learning (ML) is developed an intrinsic descriptor Φ, that correlates the catalytic activity with electronic and chemical properties of the catalytic centers at the M-N4 active site on graphene surface. A linear relationship between Φ and the catalytic activity that provides guidance for designing efficient SACs for electrocatalysis in LOBs. Zn-SAC is synthesized through chemical vapor deposition (CVD) process, which shows more stable cyclability and exhibits smaller reaction overpotentials, verifying the simulation results.

IPC Classes  ?

• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/04 - Processes of manufacture in general
• H01M 10/052 - Li-accumulators
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

Provided is the new compositions and methods useful for the treatment, prevention, and potential cure of a genetic disease, such as familial Alzheimer's Disease, by disrupting the genomic sequence harboring one or more SNPs that are of high prevalence in a population but no relevance to the particular disease except for their genomic locations being in the same gene exon as a disease-relevant allele and upstream from such disease-relevant allele present in the genome of a treatment recipient.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Provided herein is a thermal-managed photovoltaic glass glazing panel comprising a photovoltaic glazing a thermal insulation layer coated on the front surface of the photovoltaic glazing, wherein the thermal insulation layer includes a passive radiative cooling coating material; and a sound and thermal insulation module, wherein the sound and thermal insulation module comprises vacuum glazing, hollow glazing or a combination thereof, adhered to the rear side of the photovoltaic glazing. The photovoltaic glazing module of the present invention not only optimizes solar power generation through specific thermal management designs, but also minimizes both heat transfer and noise intrusion to the interior of the building, maintaining a quiet and stable internal ambient environment, minimizing impacts from the external environment.

IPC Classes  ?

• H02S 20/26 - Building materials integrated with PV modules, e.g. façade elements
• H02S 30/00 - Structural details of PV modules other than those related to light conversion

Abstract

The present disclosure relates generally to a method, apparatus, and system for predicting a pulmonary arterial hypertension condition of a subject, the method comprising: measuring, by a processor, a morphological feature of a region of a heart of the subject from a plurality of echocardiogram videos, each of the plurality of echocardiogram videos showing the heart at a different viewing angle, the morphological feature relating to the pulmonary arterial hypertension condition; and generating, by the processor, a prediction score representing a likelihood of the subject having the pulmonary arterial hypertension condition from the morphological feature.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow

Abstract

A method using AI models to generate patterns or images on a pastry is provided. The method at least includes steps as follows: providing a UI module for user input of keywords and descriptions; generating black and white vector-style images based on this input using an AI-based image module; processing the 2D image into digital instructions via an image-transformer module; sending these instructions to a laser patterning module; and using the laser patterning module to apply the pattern to the cookie's surface.

IPC Classes  ?

• G05B 19/4099 - Surface or curve machining, making 3D objects, e.g. desktop manufacturing

Abstract

A method for determining a shape of an object in an image, comprising: generating, for each of a first plurality of images, a first plurality of nodes based on a first plurality of features extracted from each of the first plurality of images, the first plurality of features associated with a shape of an object in the first plurality of images; determining, for each of the first plurality of nodes, one or more other nodes based on historical data indicating a previous position and a time associated with the previous position of each of the first plurality of nodes; and determining the shape of the object for each of the first plurality of images based on the one or more other nodes.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation

Abstract

A polymer-based composite fiber includes a matrix including one or more polymers, a plurality of voids formed in the matrix, and a plurality of solid particles, each particle of the plurality of solid particles being disposed in a respective void of the plurality of voids. The fiber may have an aspect ratio of at least 10, the fiber aspect ratio being defined as the length of the fiber divided by the diameter of the fiber. Each void of the plurality of voids may have a respective long axis, each long axis being a line that extends through a longest dimension of the void, and each long axis may extend in a direction parallel to the length of the fiber.

IPC Classes  ?

• D01F 1/10 - Other agents for modifying properties
• D01F 6/62 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyesters
• D03D 15/33 - Ultrafine fibres, e.g. microfibres or nanofibres
• D03D 15/547 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads with optical functions other than colour, e.g. comprising light-emitting fibres
• D03D 15/573 - Tensile strength
• D04B 1/16 - Other fabrics or articles characterised primarily by the use of particular thread materials synthetic threads
• D04B 21/16 - Fabrics characterised by the incorporation by knitting, in one or more thread, fleece, or fabric layers, of reinforcing, binding, or decorative threadsFabrics incorporating small auxiliary elements, e.g. for decorative purposes incorporating synthetic threads

Abstract

Re(V) alkylidyne-based catalytic systems for alkyne metathesis reactions capable of effecting alkyne metathesis, such as homo- and cross-metathesis of alkynes or diynes, ring closing metathesis and ring-opening metathesis, at room temperature to moderate temperatures. The catalysts are stable to air and moisture and tolerate a variety of functional groups in substrates and can be readily prepared on a large scale, and thus are practical catalytic systems of Re(V) alkylidynes.

IPC Classes  ?

• B01J 31/24 - Phosphines
• B01J 31/22 - Organic complexes
• C07C 29/36 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy groups, e.g. O-metal
• C07C 45/68 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by isomerisationPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by change of size of the carbon skeleton by increase in the number of carbon atoms
• C07D 211/06 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
• C07D 225/02 - Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
• C07D 321/00 - Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups
• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings

Abstract

A phased-array transmitter system includes a plurality of signal paths and a power amplifier. Each of the signal paths comprises: a phase-shifter configured to generate a phase-shifted signal; a first mixer configured to mix the phase-shifted signal with a baseband signal to generate a first mixed signal; a variable gain amplifier (VGA) configured to perform phase-invariant gain-controlled amplification on the first mixed signal; a second mixer configured to mix the amplified first mixed signal with a radiofrequency local oscillator (RFLO) signal to generate a radiofrequency (RF) signal; and a power amplifier configured to amplify the RF signal and feed the amplified RF signal to an antenna.

IPC Classes  ?

• H04B 1/403 - Circuits using the same oscillator for generating both the transmitter frequency and the receiver local oscillator frequency
• H04B 1/04 - Circuits

Abstract

A method for a photon induced conductive material deposition on a substrate is provided. The method includes steps as follows: preparing a first solution comprising metalate, metal ions, or combinations thereof; preparing a first suspension comprising nanoparticles, a light sensitive reducing agent, an electron providing solvent, or combinations thereof; mixing the first solution and the first suspension to form a first reagent on a first substrate; and emitting a light beam provided by a light source and focusing the same onto the first reagent kept on a first region of the first substrate, so as to form a mechanically rigid conductive deposition in contact with the first substrate in a focus point of the light source, wherein the first substrate has a second region exposed to surrounding gas or an air environment.

IPC Classes  ?

• H01L 21/288 - Deposition of conductive or insulating materials for electrodes from a liquid, e.g. electrolytic deposition
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or
• H01L 29/45 - Ohmic electrodes
• H01L 29/772 - Field-effect transistors

Abstract

An apparatus includes an optical writing module and an optical characterization module. The optical writing module is configured to emit a laser beam and guide the laser beam toward a substrate. The optical characterization module is optically coupled with the optical writing module such that the optical writing module and the optical characterization module share the same optical path. The optical writing module is configured to emitting an observation light beam toward the substrate. The optical characterization module is further configured to determine whether a mixture of solution and suspension is in contact with the substrate. When the mixture is determined in contact with the substrate, the laser beam is enabled to irradiate the mixture near a surface of the substrate, so as to form a mechanically rigid material deposition in contact with the substrate.

IPC Classes  ?

• B23K 26/03 - Observing, e.g. monitoring, the workpiece
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/14 - Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beamNozzles therefor
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate

Abstract

A method for preparing a composite construction material, the method including: combining plastic waste and construction waste, such as construction debris, crushed rock, stone, concrete rubbles, soil, or a mixture thereof, thereby forming a waste mixture; and curing the waste mixture under oxygen-free conditions thereby melting or softening at least a portion of the plastic waste and forming the composite construction material.

IPC Classes  ?

• B29B 17/00 - Recovery of plastics or other constituents of waste material containing plastics
• B29K 23/00 - Use of polyalkenes as moulding material
• B29K 105/26 - Scrap
• B29K 509/00 - Use of inorganic materials not provided for in groups , as filler
• B29K 509/06 - Concrete
• F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflectingArrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing

Abstract

Techniques are described for augmenting chest X-ray (CXR) images with synthetic lesions using a lesion-aware machine learning framework in association with optimizing thoracic disease detection models. In an example, a system can comprise a lesion augmentation component that generates synthetic lesion images comprising synthetic lesion image data objects integrated on or within medical images using lesion generator, trained to generate the synthetic lesion image data objects, and tailor the synthetic lesion image data objects to account for different types of lesions and different anatomical locations of the lesions. The system can further comprise a training component that trains a lesion detector using the synthetic lesion images. The training component can further perform an alternate training strategy to integrate the training of the lesion generator and the detector for mutual boosting.

IPC Classes  ?

• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting

Abstract

An aligned and multichannel peripheral nerve conduit, including Polyvinyl alcohol (PVA) and graphene oxide (GO) with aligned and multichannel design for peripheral nerve repair. 3D printing technology with assembly is utilized to make a specific mold to get a multichannel design to mimic natural peripheral nerves. Directional freeze casting is used to form an aligned PVA/GO hydrogel structure to guide cell growth.

IPC Classes  ?

• A61L 27/08 - Carbon
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C01B 32/194 - After-treatment
• C01B 32/198 - Graphene oxide

Abstract

A passive on-chip optical long-pass filter for removing residual pump photons at short wavelengths after nonlinear generation of photons. A thin layer (<100 nm) of amorphous or poly-crystalline silicon is deposited onto a section of a waveguide to absorb light with a wavelength shorter than the silicon bandgap wavelength of ˜1.1 μm, while the nonlinearly generated light in longer wavelengths than the silicon bandgap wavelength propagates in the waveguide with a negligible absorption loss. The filter is applicable to attain an on-chip optical pump light rejection ratio exceeding 120 dB for nonlinear and quantum photonic chips. The filter is conceptually simple to design and can be fabricated by a CMOS process with potentially a high wafer-level scalability and manufacturability at a low cost. The filter can be realized in various integrated photonic platforms, including silicon carbide, silicon nitride, lithium niobate and aluminum nitride.

IPC Classes  ?

• G02B 6/122 - Basic optical elements, e.g. light-guiding paths
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/125 - Bends, branchings or intersections
• H01L 31/0232 - Optical elements or arrangements associated with the device

Abstract

Compositions and methods comprising artificial poly (A) sequences having at least one cytosine and at least one uridine and/or guanosine are provided.

IPC Classes  ?

• C12N 15/67 - General methods for enhancing the expression

Abstract

This disclosure provides methods and apparatus with regard to ultrathin metal-organic frameworks for the application of carbon dioxide reduction. In one aspect, a method of preparing metal-organic frameworks by copper and second metal ion clusters coordinating with metalloporphyrinic linkers. In the other aspect, the metal-organic frameworks are coated on the working electrode as electrocatalysts for carbon dioxide reduction are presented.

IPC Classes  ?

• C25B 11/085 - Organic compound
• C25B 3/26 - Reduction of carbon dioxide
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms
• C25B 11/02 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form
• C25B 11/042 - Electrodes formed of a single material
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/065 - Carbon
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

A system is provided for training a neural network model. The system comprises one or more image acquisition devices, configured to obtain volumetric image data; and one or more processors, configured to: generate images of a plurality of views, which comprise a global complete view and one or more masked views; generate, by a Global-Local Masked AutoEncoder (GL-MAE) encoder system, representations corresponding to the global complete view and the one or more masked views; generating one or more reconstructed images corresponding to the one or more masked views; evaluating in a shared representation space, consistency between the representations of the global complete view and the one or more masked views; computing one or more losses based on the one or more reconstructed images and the results from the consistency evaluation; and updating one or more parameters in the neural network model based on the one or more losses.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06T 3/40 - Scaling of whole images or parts thereof, e.g. expanding or contracting
• G06T 7/10 - SegmentationEdge detection
• G06T 9/00 - Image coding
• G06T 15/00 - 3D [Three Dimensional] image rendering
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]

Abstract

A machine learning (ML) workflow for virtual staining and computational pathology based on a label-free tissue sample is provided to avoid a laborious and time-consuming procedure of pathologist-based interpretation of formalin-fixed and paraffin-embedded histology. A virtual-staining ML model translates a label-free autofluorescence (AF) whole slide image (WSI) of the tissue sample into a virtual hematoxylin and eosin (H&E) -stained WSI, which is further transformed into a WSI virtually stained with a special stain by a stain-transformation ML model. Each of the ML models can be realized as a U-Frame model. A multiple instance learning (MIL) network with attention-based pooling can be applied to the virtual H&E-stained WSI or AF WSI to provide fast and accurate tumor diagnosis. Furthermore, the attention-based MIL network can be configured as a clustering-constrained-attention multiple instance learning (CLAM) model for providing multiclass tumor subtyping, or even multiclass disease typing, in diagnosis of the tissue sample.

IPC Classes  ?

• G06T 17/00 - 3D modelling for computer graphics

Abstract

This invention refers to a liquid-based micro thermal convective accelerometer (MTCA) optimized using a compact model based on the Rayleigh number (Ra). The MTCA is fabricated using CMOS MEMS technology. To ensure water resistance, an isolation layer such as a waterproof cover, exemplified by the conformal Parylene C coating, is employed. The device's performance is assessed in terms of sensitivity, response time, and noise. Theoretical and experimental findings establish that fluids with higher Ra numbers yield improved MTCA performance. Ra-based model showed its advantage to make a more accurate prediction than the simple linear model to select suitable fluid to enhance the sensitivity and balance the linear range of the device. In some cases, the liquid of MTCA can be selected as alcohol, and an alcohol-based MTCA was achieved with a two-order-of magnitude increase in sensitivity and one-order-of-magnitude decrease in the limit of detection compared with the air-based MTCA.

IPC Classes  ?

• G01P 15/00 - Measuring accelerationMeasuring decelerationMeasuring shock, i.e. sudden change of acceleration
• G01K 7/22 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a non-linear resistance, e.g. thermistor

Abstract

The present invention provides a rechargeable alkaline battery with enhanced cycling stability and coulombic efficiency. The battery includes a cathode prepared with a cathode material and connected to a first terminal, an anode prepared with an anode material and connected to a second terminal, a hydroxide electrolyte with a higher concentration, and at least one porous separator positioned between the anode and the cathode. The hydroxide electrolyte inhibits hydrogen evolution from approximately 20% to less than 5% of an overall reaction. When cycled at 40% DOD under charging and discharging at 15 mA/cmZn2, the rechargeable alkaline battery exhibits a cycling stability with a capacity retention of >80% after 290 cycles.

IPC Classes  ?

• H01M 10/26 - Selection of materials as electrolytes
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/24 - Electrodes for alkaline accumulators
• H01M 4/32 - Nickel oxide or hydroxide electrodes
• H01M 50/491 - Porosity
• H01M 50/497 - Ionic conductivity

Abstract

An apparatus comprises a body made of a deformable material, and a plurality of protrusions movably attached to an inner surface of the body, each of the plurality of protrusions extending in a direction from the inner surface towards a center of the body, and configured to be moveable in the direction in response to a deformation of the body.

IPC Classes  ?

• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
• G01B 11/16 - Measuring arrangements characterised by the use of optical techniques for measuring the deformation in a solid, e.g. optical strain gauge

Abstract

A heat spreader composed of a hexagonal boron carbon nitride (hBCN) thin film, can be a major solution for the ever-increasing problem of overheating electronic devices. This heat spreader can dissipate heat away from hotspots on electronic devices, unlocking additional processing power. Our method is able to effectively tune the thermal and electrical conductivity of our films by modulating the carbon content of the precursor used in a chemical vapor deposition (CVD) process. Using this method, we can generate a heat spreader that is electrically insulative, so it will not have the potential to create shorts, like graphene and metals. Additionally, we can maximize the thermal conductivity, obtaining a value of 460±149 W/m·K, which rivals or even surpasses hexagonal boron nitride (hBN). As our precursor material is 10 times cheaper than the most common hBN precursor, this is an economical alternative to hBN for heat spreader applications.

IPC Classes  ?

• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
• C01B 21/064 - Binary compounds of nitrogen with metals, with silicon, or with boron with boron
• C09K 5/14 - Solid materials, e.g. powdery or granular
• C23C 16/36 - Carbo-nitrides

Abstract

This system presents a comprehensive approach for detecting protein-protein interactions and exploring protein structures. It encompasses various components, including a receptacle for receiving cross-linked precursor peptides, a mass spectrometer for generating MS1 and MS2 spectra, and modules for precursor mass refinement, MS2 spectrum scoring, protein score database construction, and feedback mechanism processing. Through the integration of these elements, the system facilitates the identification of peptide interactions and protein structures, leveraging a cross-linking dataset obtained from proteins cross-linked with cleavable or non-cleavable crosslinking reagents.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

A method and an apparatus for decoding channel codes received from a noisy communication channel are provided. The method comprises: demodulating the received channel codes to obtain a demodulated data vector; and decoding, using a compute-in-memory (CIM), the demodulated data vector to obtain one or more candidate output codewords, the demodulated data vector is decoded with a guessing random additive noise decoding (GRAND) algorithm to obtain a candidate output codeword. By leveraging CIM technique for GRAND implementation, due to the intrinsic small size of memory cells relative to logic gates, the integration of storing and computing operations (e.g. multiply-and-accumulate (MAC) operation on the input vector with the weight matrix) in memory cells enables concurrently evaluating a multitude error patterns, therefore substantially reduce the worst-case latency of GRAND hardware implementation.

IPC Classes  ?

• G06F 11/36 - Prevention of errors by analysis, debugging or testing of software

Abstract

Translational rapid ultraviolet-excited sectioning tomography (TRUST) applies ultraviolet (UV) excitation to a sample and images fluorescence and autofluorescence emission for tomographically imaging the sample. Deep-learning neural networks are used to achieve higher imaging speed and imaging resolution. In one use, fluorescence images acquired with relatively low imaging resolution can be transformed into high-resolution images through the first conditional generative adversarial network (cGAN), a super-resolution neural network (e.g., ESRGAN), which is also helpful for reducing the image scanning time. In another use, the second cGAN, such as Pix2Pix, is used to realize virtual optical sectioning to enhance the axial resolution of the imaging system. Compared to the conventional pattern illumination methods (e.g., HiLo microscopy), which need at least two shots for each field of view, the imaging speed is also times higher because only one shot under the uniform-illumination condition of UV irradiation is required.

IPC Classes  ?

• G06T 3/4046 - Scaling of whole images or parts thereof, e.g. expanding or contracting using neural networks
• G06T 7/00 - Image analysis

Abstract

A collaborative nexus device for solving climate change mitigation and water sustainability. The device comprises a connecting port and a processor. The processor obtains at least one task data from a plurality of request ends and at least one candidate data from a plurality of bidding ends through the connecting port. The processor matches a plurality of items related to climate change mitigation and water sustainability of the candidate data with at least one of the task data. The processor providing a collaborative contract to the request end corresponded to the matched task data and the bidding end corresponded to the matched candidate data. The processor provides a collaborative space to both the matched request end and the matched bidding end. A system for collaborative nexus is also provided.

IPC Classes  ?

• G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
• G01W 1/00 - Meteorology

Abstract

Systems and methods for multi-spectral and label-free autofluoresence histochemical instant virtual staining are provided. The system includes a sample holder, one or more light sources, an imaging device, and a processor means. The sample holder is configured to secure a sample on a movable structure that is movable in at least two dimensions. The one or more light sources are configured to obliquely illuminate the sample for excitation of the sample. The imaging device is configured to capture images of the sample and the processing means is configured to receive the images of the sample and process the images in accordance with a histochemical virtual staining process. The images include an autofluorescence image and the histochemical virtual staining process includes subdividing the autofluorescence image into a plurality of regions, global sampling a selected region of the autofluorescence image, and classifying the autofluorescence image as one of a plurality of real image classifications or a fake image classification.

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G01N 1/30 - StainingImpregnating
• G01N 1/31 - Apparatus therefor
• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
• G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting

Abstract

Provided is a recombinantly produced fusion protein that includes an optically responsive element fused to a downstream signaling element derived from an active domain of a signaling molecule, such as the intracellular domain of a receptor protein, and is therefore capable of triggering the signal transduction cascade by light exposure rather than the native activating event to the signaling molecule, such as the binding of a ligand to the receptor. The nucleic acid encoding the fusion protein and the host cells containing the fusion protein or the nucleic acid are also provided. Further provided are methods of using light exposure to achieve desirable downstream effects of a signal transduction pathway normally mediated by the signaling molecule, for example, in the promotion optic neuronal cell proliferation, survival, and/or regeneration.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

Microfluidic devices having microwell arrays that enable scalable and parallel droplet multi-step reactions and associated methods for implementing reactions in paired microwells of two different sizes via numerous repeating units of trapping wells as well as sequentially collecting and merging droplets. Droplets that contain the desired species or reagents for reactions are input onto the microfluidic platform. Each well is set up to initially capture one larger droplet, then repeatedly capture smaller ones, followed by merging of larger and smaller droplets. In some embodiments, this action is facilitated by tilting the chip. In some implementations, larger droplets merge three batches of paired, smaller droplets with various needed components in succession while conducting incubation in between the merge and loading. In alternative implementations, each trapping well has two or more active capture sites that merge multiplexed smaller droplets simultaneously and merge more than once.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 1/00 - Apparatus for enzymology or microbiology
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

Abstract

The present invention belongs to the field of nanomedicine, and provides a DC biomimetic membrane nanoparticle loaded with an NIR-II AIE dye, a preparation method therefor and use thereof. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye comprises a DC membrane and an NIR-II AIE dye loaded therein, wherein the NIR-II AIE dye has photothermal characteristics. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye provided by the present invention not only solves the problem that the NIR-II AIE dye is poor in water solubility and limited in fluorescence imaging, but also increases the enrichment efficiency of the NIR-II AIE dye coated by the DC membrane at a tumor site and successfully activates the activity of T cells in vivo.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 35/00 - Antineoplastic agents

Abstract

A method useful for preparing butenolides in high yield, the method comprising: contacting an aldehyde, malonic acid, and an organic base thereby forming a Knoevenagel condensation product; and contacting the Knoevenagel condensation product, an oxidant, a metal halide, and optionally an inorganic base thereby forming the butenolide.

IPC Classes  ?

• C07D 307/33 - Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Abstract

A pinhole compound eye (PHCE) system includes: a pinhole array comprising a plurality of pinholes, wherein the pinhole array is configured to receive light from varying incident angles; and a detector array comprising a plurality of nanowires, wherein the detector array is positioned at a concave surface of the pinhole array and is configured to detect light passing through the pinhole array.

IPC Classes  ?

• H01L 27/146 - Imager structures
• B33Y 80/00 - Products made by additive manufacturing
• G02B 5/20 - Filters
• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

Provided are new compositions and methods useful for the treatment, prevention, and potential cure of Alzheimer's Disease by disrupting the genomic locus of IL1LR1 gene including rs1921622 and/or other 574 sST2-associated genomic sites and/or 3′-UTR of sST2 gene/transcript.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The subject invention pertains to a method for promoting axon regeneration in a subject, including those with central nervous system (CNS) injury, by activation of Nrf2 induced by edaravone.

IPC Classes  ?

• A61K 31/4152 - 1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A system for cost management using blockchain and encryption is provided. The system includes an access interface, a recorder, a determinator, a key generator, an encryptor, and a decryptor. The access interface is configured to provide a platform for users to log in. The recorder is for recording cost information. The determinator is configured to determine whether the cost information recorded in the recorder is non-sensitive. When the cost information is determined as being non-sensitive, the cost information is directly uploaded to and recorded on a blockchain network via a smart contractor module. When the cost information is determined as being sensitive, the key generator generates a symmetric key randomly. The encryptor is configure to encrypt the cost information using the symmetric key to obtain ciphertext information and encrypt the symmetric key using public keys to obtain encrypted keys. The encryptor sends the ciphertext information to the blockchain network.

IPC Classes  ?

• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
• H04L 9/40 - Network security protocols

Abstract

An automatic three-dimensional (3D) joint erosion detection method and systems for the diagnosis and monitoring of rheumatoid arthritis using HR-pQCT images of a hand is provided. The method includes following steps: providing HR-pQCT images containing joint volumes as inputs; segmenting joint bones from the HR-pQCT images; separating the joint bones from joint space based on the joint segmentation; constructing a cortical surface from the joint separation; estimating surface curvature from the cortical surface; aggregating concave regions based on the surface curvature; and determining erosion regions from the concave regions. The performance of the 3D joint erosion detection method is demonstrated to be superior to the performance of the existing methods.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

The present disclosure provides a sensor system comprising a sensor array including a plurality of sensors and is configured to generate analog signals; an amplifier coupled to the sensor array, the amplifier configured to amplify the received analog signal; a buffer in communication with the amplifier, the buffer is configured to receive the amplified analog signal from the amplifier and cache the amplified analog signal therein; an analog-to-digital converter coupled to the amplifier and the buffer, and a signal selector configured to control delivery of the amplified analog signal from the amplifier.

IPC Classes  ?

• H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
• G16Y 40/20 - AnalyticsDiagnosis

Abstract

The subject invention pertains to hexacyclic xanthones isolated from marine bacteria. These chrexanthomycins are effective TRPV1 inhibitors that are effective as analgesics.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

Compositions and methods are provided for the assessment and treatment of age-related conditions and diseases. Also provided are methods for identifying compounds that can potentially regulate the aging process.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A synchronous coefficient of drag alteration method and system for concentrating and purifying nucleic acids from a sample containing unwanted molecules and contaminants are provided. The method includes providing a layer of artificial gel or sieve filled with liquid and into which molecules including nucleic acids are introduced from a sample liquid by applying a steady electric field across a boundary between the artificial gel layer and the sample liquid containing the molecules including nucleic acids; providing a plurality of electrodes spaced apart around circumference of the artificial gel layer and for delivering a pre-programmed sequence of voltage waveforms to establish a primary electric field driving molecules within the artificial gel layer and a secondary electric field altering electrophoretic mobility of molecules within the artificial gel layer. The nucleic acids alone are spatially separated from the unwanted molecules and contaminants to be relatively purified and enriched.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 27/447 - Systems using electrophoresis
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

A neurite growth stimulator is a small molecule ENPP1 inhibitor. The small molecule ENPP1 inhibitor allows treatment of a central nervous system (CNS) injury with promotion of axon regeneration. The ENPP1 inhibitor in a vehicle can be administered to a neurological injury to promote the regeneration of axons.

IPC Classes  ?

• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• C07D 471/00 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention relates to protein markers relevant to mild cognitive impairment (MCI) and Alzheimer's disease (AD), especially those detectable in blood samples. Thus, methods and compositions are provided for risk assessment and early diagnosis of MCI and AD based on the analysis of these protein markers. Further provided are methods and compositions useful for evaluating the efficacy of a therapy for MCI or AD.

IPC Classes  ?

• G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation

Abstract

A coating composite including an outer slippery interface layer disposed on a surface of a photothermal layer, wherein the outer slippery interface layer includes a first poly(dialkylsiloxane) and an oil; and the photothermal layer includes photothermal nanoparticles and a second poly(dialkylsiloxane), a kit including the coating composite precursors, and methods of preparing the coating composite. The coating composite exhibits anti-icing and anti-frosting properties.

IPC Classes  ?

• C09D 143/04 - Homopolymers or copolymers of monomers containing silicon
• C08F 30/08 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon
• C08K 3/28 - Nitrogen-containing compounds
• C09D 7/63 - Additives non-macromolecular organic
• C09D 7/80 - Processes for incorporating ingredients

Abstract

A gate clamping circuit for driving a wide bandgap (WBG) device is provided. The gate clamping circuit comprises: a semiconductor switching device having a high side terminal connected to a gate of the WBG device; and a low side terminal connected to a source of the WBG device; a clamping resistor having a first end connected to a negative power supply terminal of a driver chip; and a second end connected to a control terminal of the semiconductor switching device; and a clamping capacitor having a first end connected to the second end of the clamping resistor; and a second end connected to the low side terminal of the semiconductor switching device; wherein the gate clamping circuit is configured to clamp negative voltage spike generated at the gate of the WBG device to suppress overstress of the gate of the WBG device when a negative off-state gate voltage is applied.

IPC Classes  ?

• H03K 17/081 - Modifications for protecting switching circuit against overcurrent or overvoltage without feedback from the output circuit to the control circuit

Abstract

The subject invention pertains to the multiplex detection of nucleic acid molecules. This invention provides oligonucleotides labeled with a fluorophore and a quencher and oligonucleotides with target binding regions that are broadly compatible with the detection of multiple variant locus or multiple nucleic acid samples. Additionally, this disclosure also describes methods to label detection targets by asymmetric labeled amplification and differentiate the target sequences.

IPC Classes  ?

• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
• C12Q 1/6844 - Nucleic acid amplification reactions

Abstract

One example embodiment is a method for preparing a sample including one or more RNA molecules, including the steps of: (i) reacting the sample with a reaction mixture including a poly(A) polymerase and one or more predefined nucleotide analogues to add a first sequence including one or more predefined nucleotide analogues to individual 3′-end of the one or more RNA molecules, such that one or more first tailed RNA is formed; and (ii) adding a plurality of adenosine triphosphates (ATP) to the reaction mixture, such that the first tailed RNA is reacted with a plurality of adenosine triphosphates (ATP) to add a second sequence including a plurality of adenine nucleotides to individual 3′-end of the first tailed RNA, such that one or more second tailed RNA is formed. Other example embodiments are described herein. In certain embodiments, the disclosed methods and kits are quick, simple and easy to operate.

IPC Classes  ?

• C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

Provided is a modified poly (A) tail for use in a recombinantly produced mRNA molecule for the purpose of improving protein expression from the mRNA. Thus, new and effective compositions and methods useful for enhancing the expression of a protein of interest are provided.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/67 - General methods for enhancing the expression

Abstract

A nickel-titanium alloy, and a preparation method therefor and a use thereof. The nickel-titanium alloy comprises titanium, nickel, copper and optional cobalt; based on the total weight of the nickel-titanium alloy, the weight percentages of the titanium, nickel, copper and optional cobalt are respectively: titanium: 38-47%; nickel: 35-50%; copper: 3-20%; and optional cobalt: 0-5%. The nickel-titanium alloy does not suffer from structural fatigue and/or functional fatigue after being subjected to at least ten million loading-unloading cyclic phase transformations.

IPC Classes  ?

• C22C 19/03 - Alloys based on nickel or cobalt based on nickel
• C22C 14/00 - Alloys based on titanium
• C22F 1/00 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
• C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon

Abstract

A technique for detection, classification and location identification of defects in a pressurized pipe network uses supervised machine learning and transient response signals (TRSs) of potential defect scenarios as training data. The TRSs are obtained from a model and/or measurements. The TRSs are arranged in an appropriate matrix form and its singular vectors (SVs) are obtained using singular value decomposition. The defect detection and classification procedure is conducted by projecting a measured TRS of the pipe network into a SV space. The location of the measured TRS in the SV space indicates the state of defective pipe section (if any), classify the defect according to clusters of training data (e.g., leak, blockage), and locate the defect within an identified defective section. The technique can accurately detect defective pipes in a network with a training data set as small as three scenarios per pipe section and one single measurement location.

IPC Classes  ?

• F17D 5/02 - Preventing, monitoring, or locating loss
• G01M 3/28 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for valves

Abstract

Provided is a safe and effective photosensitizer that expands the clinical use of photodynamic therapy (PDT) as a non-invasive cancer treatment. Specifically, Provided are methods of using water-soluble chlorophyll protein (WSCP) as a new photosensitizer for cancer phototherapy. Advantageously, WSCP is stable, non-toxic, and biocompatible while generating reactive oxygen species, making it useful for deep-tissue PDT.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 35/00 - Antineoplastic agents

Abstract

A transient-based time reversal (TR) technique for acoustic imaging of a pressurized water supply pipeline is provided. Measured multi-input-multi-output (MIMO) imaging data at high frequency (10kH-100 kHz) are processed by an adapted Time Reversal-MUltiple SIgnal Classification (TR-MUSIC) algorithm to provide a high-resolution image of a pipeline section about 100 m long. The resultant image reveals the pipe wall inner and outer condition, and incipient and existing defects at a scale up to millimeters. The technique is tested and validated in a laboratory environment and in a large-scale facility on pressurized water-filled viscoelastic high-density polyethylene pipes. Furthermore, the technique can be applied to different fluids and pipe materials. In addition, the technique is computationally efficient, and nondestructive. The technique requires only local intrusion for placing transducers at an access point.

IPC Classes  ?

• G01M 3/24 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using infrasonic, sonic, or ultrasonic vibrations
• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
• G01N 29/24 - Probes
• G01N 29/42 - Detecting the response signal by frequency filtering

Abstract

Provided is an in situ cell purification method. More specifically, the method includes a synthetic mRNA switch and a synthetic peptide. The synthetic mRNA switch contains a sequence encoding cell surface alkaline phosphatase operably linked to a sequence targeting a cytosolic cell type marker molecule or a viral coat protein and/or a sequence targeting a cytosolic cell type marker molecule and a viral coat protein. The synthetic peptide is a phosphorylated D-amino acid formed peptide with N terminus modified with aromatic rings.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

Abstract

An atmospheric water harvester includes: a hygroscopic polymer; and a hydrophobic matrix whereby the hygroscopic polymer is embedded in the hydrophobic matrix. In a particular embodiment, the hygroscopic polymer is chitosan and the hydrophobic and elastic matrix is silica xerogel. Further, a method of harvesting water from an atmosphere includes the steps of providing an atmospheric water harvester in an atmosphere, capturing water on the hygroscopic polymer by exposing the atmospheric water harvester to water vapor in the atmosphere for a period of time, and mechanically removing the captured water from the atmospheric water harvester after the period of time. The period of time ranges from 1 day to 30 days, the hygroscopic polymer is chitosan, and the hydrophobic matrix is made of silica xerogel.

IPC Classes  ?

• B01D 53/26 - Drying gases or vapours

Abstract

A device for employing an efficient neural network architecture through partial convolution is provided, including a fast network module, a data input module, and an outcome module. A fast neural network including multiple fast neural network blocks with at least one PConv layer and at least two PWConv layers are integrated in the fast network module. The data input module is responsible for loading and providing input data to the fast network module. The PConv layer is applied for partial convolution of the input data with achieving standard convolution operations on partial channels while preserving other channels unaffected and selectively convolves only a portion of input channels by leveraging redundant information in feature maps. The two PWConv layers following the PConv layer are configured to transform and integrate features. The outcome module is configured to receive results generated by the fast network module.

IPC Classes  ?

• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

Materials and methods for capturing target proteins and analyzing the proteins using an antibody conjugated to an oligonucleotide are provided. Methods of using rolling circle amplification (RCA) to amplify to the oligonucleotide are also provided. The oligonucleotide contains multiple sites for probe binding, which allows for multiplexity by means of color-combinatorial and sequential fluorescence in situ hybridization (ccs-FISH).

IPC Classes  ?

• C12Q 1/6841 - In situ hybridisation

Abstract

A drug administering device includes a spherical body, a magnetic actuator, and a plurality of microneedles. The magnetic actuator is arranged within the spherical body and configured to respond to an externally applied magnetic field. The plurality of microneedles are arranged on the spherical body, and the microneedles are configured to penetrate tissue.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A defect detection method is provided for a pressurized pipe having at least one defect. According to the method, an acoustic source generates a probing wave of a frequency range from 10 kHz to 100 kHz, where the probing wave is scattered by the at least one defect to create a reflected wave; an acoustic receiver measures a wave response to obtain a measured response, where the measured response is attributed essentially to a superposition of the probing wave and the reflected wave; and a computer device processes the measured response to locate the at least one defect.

IPC Classes  ?

• G01N 29/34 - Generating the ultrasonic, sonic or infrasonic waves
• G01N 29/12 - Analysing solids by measuring frequency or resonance of acoustic waves
• G01N 29/24 - Probes
• G01N 29/36 - Detecting the response signal

Abstract

Provided is a novel bead-based platform that can be used to screen various immune active peptides and designer peptide candidates and combinations for their immunogenic or tolerogenic potential. More specifically, the platform uses peptides that are specified by parameters to increase their efficiency on immune cell differentiation.

IPC Classes  ?

• C08J 3/075 - Macromolecular gels
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein

Abstract

It pertains to a novel platform for the sustained release of Type-1 diabetes antigens. More specifically, it provides a combination of dual sized hydrogel particles for the delivery of Type-1 diabetes antigens and multi-component adjuvants to confer immune tolerance.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention provides a two-step method to fabricate a nanoporous metal surface layer supported on the macroscopic metallic foam. The porous structure has an average ligament/pore size from dozens to a few hundred nanometers. The prepared monolithic electrode can simultaneously maintain a rigid metallic skeleton for good mechanical integrity, electrical conductive and hydraulic permeability while the porous layer increase surface area and therefore showcases good performance in the flow-cell, such as Zn-Iodide flow cells and electrochemical organic synthesis.

IPC Classes  ?

• C25D 5/50 - After-treatment of electroplated surfaces by heat-treatment
• C25D 3/22 - ElectroplatingBaths therefor from solutions of zinc
• H01M 8/04186 - Arrangements for control of reactant parameters, e.g. pressure or concentration of liquid-charged or electrolyte-charged reactants
• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

Abstract

Provided are a stilbene compound and a preparation method therefor and a use thereof. The structure of the stilbene compound is as shown in general formula (I), wherein X is halogen. Compared with resveratrol, the stilbene compound can more effectively inhibit binding of VEGF and a receptor VEGFR-1 so as to inhibit generation of new blood vessels.

IPC Classes  ?

• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia
• A61P 17/06 - Antipsoriatics
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 27/02 - Ophthalmic agents
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

A method of defect detection is provided for a pressurized pipe having an upstream node and a downstream node. The method comprises generating, by a wave source located at xS at the downstream node, a transient wave travelling in a direction from the downstream node towards the upstream node, measuring, by a pressure sensor located at xR upstream of the wave source, a transient response caused by the transient wave to obtain a measured signal; and processing, by a computer device to execute a time-reversal (TR) algorithm, the measured signal for determining one or more defects of the pressurized pipe.

IPC Classes  ?

• G01M 3/28 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for valves
• G06F 17/14 - Fourier, Walsh or analogous domain transformations

Abstract

A disinfectant composition comprising a dihalobenzoquinone, such as 2,6-dichloro-1,4-benzoquinone, and a solvent useful in a method of treating an object supsected of being contaminated with one or more microorganisms, the method comprising contacting the object with the disinfectant composition under conditions such that the disinfectant composition inactivates at least a portion of the one or more microorganisms.

IPC Classes  ?

• A01N 29/04 - Halogen directly attached to a carbocyclic ring system
• A01P 3/00 - Fungicides

Abstract

The ultra-low frequency acoustic absorber (10) includes a hollow housing (12) having opposed first and second open ends (22, 24), and a plurality of metallic mesh layers (16) stacked within the housing (12). In order to secure the plurality of metallic mesh layers (16) within the hollow housing (12), first and second mesh covers (18, 20) may cover the first and second open ends (22, 24) of the hollow housing (12), respectively. At least one spacer (14) may be provided to form a gap between the housing (12) and a support surface, such as a hard wall (W) or the like. The at least one spacer (14) may have a length sufficient to space the ultra-low frequency acoustic absorber (10) at the position of optimal absorption based on an acoustic soft 10 boundary condition (ASBC).

IPC Classes  ?

• G10K 11/162 - Selection of materials
• B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
• G10K 11/172 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using resonance effects

Abstract

A high-power single-frequency laser system and a method for implementing the same. The system and method require only a photodetector (110) and a narrow optical bandpass filter (108) to probe the spectral mode of slave laser (106), no additional bulky devices are required. The photodetector (110) and narrow optical bandpass filter (108) can be easily integrated into the beam path. The spectral mode of slave laser (106) is monitored through the reflected signal from the narrow-laser line filter (108), which is neither sensitive to beam alignment nor bandwidth limited. As a result, high spectral mode purity and low intensity noise of the slave laser (106) can be simultaneously obtained. The slave laser (106) can be locked even when the master laser (102) frequency is dynamically scanned over GHIz range. The system and method can be applied in laser cooling and trapping of atoms towards degenerate dipolar quantum gases.

IPC Classes  ?

• H01S 5/40 - Arrangement of two or more semiconductor lasers, not provided for in groups
• H01S 5/00 - Semiconductor lasers
• H01S 5/0687 - Stabilising the frequency of the laser
• H01S 5/14 - External cavity lasers

Abstract

Method of preparing a quantum rod nanocomposite, the method involving: combining a CdSe/CdS quantum rod, a metal ion catalyst, and a zinc precursor thereby forming a CdSe/CdxZn1-xS/ZnS quantum rod, wherein 0≤X<1; optionally purifying the CdSe/CdxZn1-xS/ZnS quantum rod; combining the CdSe/CdxZn1-xS/ZnS quantum rod with an inorganic oxide precursor thereby forming an inorganic oxide encapsulated CdSe/CdxZn1-xS/ZnS quantum rod, wherein the CdSe/CdxZn1-xS/ZnS quantum rod is at least partially encapsulated by an inorganic oxide coating; and optionally combining the inorganic oxide encapsulated CdSe/CdxZn1-xS/ZnS quantum rod with a binder thereby forming a binder coated inorganic oxide encapsulated CdSe/CdxZn1-xS/ZnS quantum rod and curing the binder thereby forming the quantum rod nanocomposite.

IPC Classes  ?

• C09K 11/88 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
• C08K 9/10 - Encapsulated ingredients
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor

Abstract

An electrocardiographic (ECG) device and fabrication methods of the ECG device are provided for sensing cardiac activities in a test subject. The ECG device includes a plurality of electrodes and a plurality of bridges connecting adjacent electrodes of the plurality of electrodes. The electrodes each has a structure including a first layer and a third layer disposed above the third layer, a second layer of liquid metal disposed between the first and third layers, and a fourth layer of conductive material disposed on the third layer, and the second layer of liquid metal is electrically connected with the fourth layer of conductive material. Each electrode may include a metal film connecting the second layer of liquid metal with the fourth layer of conductive material. The first and third layers are formed with stretchable material, making the ECG device skin-adherent, highly stretchable, and conformal.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/257 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes
• A61B 5/266 - Bioelectric electrodes therefor characterised by the electrode materials containing electrolytes, conductive gels or pastes
• A61B 5/282 - Holders for multiple electrodes

Abstract

A method for detecting an event of collision on an outer shell of a robotic device is provided. The method includes detecting acoustic waves by a plurality of transducers mounted inside or outside the outer shell; estimating, by a processor, a position of collision on the outer shell by performing arrival time analysis on the acoustic waves detected by the plurality of transducers; determining, by the processor, an extent of collision based on intensities of the acoustic waves detected by the plurality of transducers; and performing non-destructive testing of the outer shell of the robotic device automatically after detecting the event of collision to determine a level of severity to the robotic device caused by the event of collision.

IPC Classes  ?

• B25J 19/06 - Safety devices
• B25J 13/00 - Controls for manipulators
• G01V 1/00 - SeismologySeismic or acoustic prospecting or detecting

Abstract

Provided in the present invention are a multi-sensor apparatus and a joint data collection assembly comprising same. The multi-sensor apparatus comprises: an upper computer; a synchronization unit; and at least two different types of sensors, wherein the synchronization unit is coupled to each of the at least two different types of sensors, and is configured to send a trigger signal to each of the sensors, so as to synchronously trigger each of the sensors to perform data collection; and each of the at least two different types of sensors is coupled to the upper computer, and is configured to send collected data to the upper computer. By using the solution of the present invention, while multi-sensor data fusion is realized, the difference between times that related data is collected from sensors can be minimized, thereby reducing or avoiding the adverse effect on data fusion during the subsequent use of the data due to a time deviation. Therefore, the present invention can facilitate better fusion of data from different sensors.

IPC Classes  ?

• G01D 21/02 - Measuring two or more variables by means not covered by a single other subclass
• G01C 21/16 - NavigationNavigational instruments not provided for in groups by using measurement of speed or acceleration executed aboard the object being navigatedDead reckoning by integrating acceleration or speed, i.e. inertial navigation

Abstract

Anthraquinone-based covalent organic frameworks; methods for preparing anthraquinone-based covalent organic frameworks; solid electrolyte interphases including the anthraquinone-based covalent organic frameworks; and electrochemical devices including the solid electrolyte interphases. The solid electrolyte interphases can exhibit enhanced transport of Li+. Battery cells including the solid electrolyte interphase exhibit improved reversible capacities.

IPC Classes  ?

• C07F 7/08 - Compounds having one or more C—Si linkages
• H01M 10/056 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes

Abstract

A composite solid-state electrolyte, a preparation method thereof and an all-solid-state lithium metal battery. The composite solid-state electrolyte includes a cationic poly(ionic liquid) as a matrix; and an ionic covalent organic framework, TpPa—SO3Li, as a filler. The method for preparing a composite solid-state electrolyte includes combining the poly(ionic liquid) with the ionic covalent organic framework to prepare the composite solid-state electrolyte. The composite solid-state electrolyte can have excellent ionic conductivity up to 1.23×10−3 Scm−1 and Li ion transport number (tLi+) up to 0.82 at room temperature. The composite solid-state electrolyte and the all-solid-state lithium metal battery containing the composite solid-state electrolyte provided by the present invention can achieve long-term safety while achieving high performance, and show great potential in the practical application of all-solid-state lithium metal batteries with high security.

IPC Classes  ?

• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

122, X and Y are as defined in the present disclosure.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents
• C07D 471/04 - Ortho-condensed systems

Abstract

A system for flow-count includes one or more cameras and a processing system. The one more cameras are configured to capture image data comprising a sequence of frames. The processing system is configured to extract spatial features and temporal features based on the sequence of frames; construct, based on the spatial features and temporal features, a density map and/or a flow map corresponding to a frame of the sequence of frames, wherein the density map comprises density values for the plurality of pixels, wherein the flow map comprises two-dimensional (2D) vectors for the plurality of pixels, and wherein a 2D vector indicates a speed and direction for a pixel of the plurality of pixels in the frame; and determine, based on the density map and/or the flow map, a count, a distribution, and/or movement of objects corresponding to the frame.

IPC Classes  ?

• G06T 7/269 - Analysis of motion using gradient-based methods
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments

Abstract

The subject invention pertains to a method for promoting axon regeneration in a subject with central nervous system injury. More specifically, the method comprises activating STAT1 signaling, cGAS-STING pathway, or a combination thereof by administering IFNγ and inhibiting the expression or function Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) inhibitor; or administering a STING agonist.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/433 - Thiadiazoles
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 25/00 - Drugs for disorders of the nervous system
• C12N 5/0793 - Neurons
• C12N 9/22 - Ribonucleases

Abstract

The subject invention relates to a contamination-free method that utilizes CRISPR/Cas enzyme specific sequence recognition towards the loop region in the LAMP amplicons to accomplish one-pot detection for rapid visual readout diagnostics of the presence or absence of target nucleic acid sequences.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12N 9/22 - Ribonucleases
• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• C12Q 1/6844 - Nucleic acid amplification reactions
• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

122, X and Y are as defined in the present disclosure.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention discloses aggregation-induced emission fluorescent compounds with near-infrared (NIR) emission. The present invention also shows application for imaging-guided phototheranostic with the integration of both photodynamic therapies and photothermal therapies. The in vitro and in vivo verification further confirmed that this system exhibits outstanding fluorescence-guided phototheranostics ability to eliminate tumors effectively.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• A61K 31/433 - Thiadiazoles
• A61P 35/00 - Antineoplastic agents

Abstract

A rapid, label-free, non-destructive imaging method and system (100) for unprocessed biological tissue, which is based on microscopy with ultraviolet single plane illumination (MUSI). The present system (100) or method employs a selective two-axis planar illumination configuration, which decouples the illumination from the detection path, and utilize the intrinsic fluorescence of certain endogenous fluorophores from biological tissues as a natural source compared to deep UV illumination sources. In contrast to images produced by clinical standard methods (i.e. H&E staining of formalin-fixed and paraffin-embedded tissues), images generated by MUSI reveal comparable or even better diagnostic features, providing clinicians, pathologists, and surgeons with greater potential as post-operative and intra-operative diagnostic tools.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry

Abstract

The present invention discloses aggregation-induced emission fluorescent compounds with near-infrared (NIR) emission. This fluorescent compound is then encapsulated by polymer matrix to yield nanoaggregates which is confirmed to show an excellent photothermal conversion efficiency while maintaining a high fluorescence quantum yield. Consequently, the photothermal therapeutic efficacy can be improved by PTA-oriented accumulation of nanoaggregates, compared with the barely enhanced permeability and retention (EPR) effect. The in vitro and in vivo verification further confirmed that the nanoaggregates exhibit superior fluorescence-guided phototheranostics ability to eliminate tumors.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• A61K 31/433 - Thiadiazoles
• A61P 35/00 - Antineoplastic agents

Abstract

A 3D food printer includes a printer head including, an extrusion nozzle and a laser assembly with at least one laser, and a heated printing platform. The extrusion nozzle is configured to extrude food onto the printing platform, and each of the printing platform and the at least one laser are configured to heat food extruded onto the printing platform.

IPC Classes  ?

• A23P 20/20 - Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
• A23L 5/10 - General methods of cooking foods, e.g. by roasting or frying
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• H05B 3/00 - Ohmic-resistance heating

Abstract

Provided is a protein marker Nell-1, which is present in a person's blood sample in an amount that is correlated with neurodegenerative disorders such as Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and Parkinson's Disease (PD). Corresponding diagnostic and treatment methods for these neurodegenerative disorders as well as kits for diagnosing or treating the neurodegenerative disorders are also provided.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The subject invention pertains to systems and methods to improve the condition of an eye and to either treat or lower the risk of diseases such as glaucoma. Systems and methods are provided for increasing compliance, improving circulation and fluid flow, or promoting tissue cell metabolism by warm compress, and/or irradiation at single or multiple wavelengths (e.g., between 780 to 950 nm or between 550 to 700 nm), and/or application of static and/or dynamic pressure to the eye. Embodiments provide a wearable head set with pressure controlled goggles, controlled irradiation sources, and temperature-controlled heat sources or pads exposed to or in contact with the eye or surrounding region to warm up the tissues of the eye and promote the vasodilation of the blood vessels at the eye as well as circulation within the blood system connected to the Schlemm's canal or other regions in or around the eye.

IPC Classes  ?

• A61H 5/00 - Exercisers for the eyes
• A61N 5/06 - Radiation therapy using light

Abstract

An anode materials VSe2/Zn, including a functional Vanadium diselenide (VSe2) with graphene support composite coated on the Zn metal with super ion conductivity, is used in a zinc ions battery. The synthesis process includes polymerization and chemical vapor deposition process for selenization with selenium powder.

IPC Classes  ?

• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/42 - Alloys based on zinc

Abstract

An antenna structure including a first and a second radiating elements, a first and a second ground planes, and a connecting structure is provided. The first ground plane is disposed adjacent to the first radiating element and is coupled to the first radiating element. The second ground plane is disposed adjacent to the second radiating element and is coupled to the second radiating element. The connecting structure connects an edge of the first ground plane to an edge of the second ground plane, such that the first ground plane is connected to the second ground plane through the connecting structure.

IPC Classes  ?

• H01Q 1/38 - Structural form of radiating elements, e.g. cone, spiral, umbrella formed by a conductive layer on an insulating support

Abstract

A lipophilic anchor includes a conjugation domain linked via a linker domain to an anchor domain having a plurality of hydrophobic tails. This lipophilic anchor allows deposition of at least one lipophilic target molecule with affinity for the anchor domain on a hydrophilic surface conjugated to the conjugation domain. The lipophilic target molecule coated hydrophilic substrate has the conjugation domain of the lipophilic anchor bound to the hydrophilic surface of a substrate and lipophilic target molecules are non-covalently bound to the anchor domain.

IPC Classes  ?

• C07C 323/52 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

Abstract

Method for preparing a sustainable construction material, the method including: combining construction waste, food waste comprising calcium, and water thereby forming a waste mixture; optionally moulding the waste mixture; and contacting the waste mixture with CO2 under conditions in which at least a portion of the calcium present in the waste mixture is converted to calcium carbonate thereby forming a treated waste mixture thereby forming the sustainable construction material.

IPC Classes  ?

• C04B 18/30 - Mixed wasteWaste of undefined composition, e.g. municipal waste
• C04B 18/02 - Agglomerated materials
• C04B 18/167 - Recycled materials, i.e. waste materials reused in the production of the same materials