Abstract

Featured are methods, compositions, and apparatuses for the in vitro maturation of oocytes. In particular, the disclosure features methods of inducing oocyte maturation in vitro, by co-culturing a female subject's oocytes with an ex vivo composition containing a plurality of ovarian support cells (e.g., granulosa cells). Additional methods for administering follicular triggering agents and retrieving oocytes from the female subject are provided. Such methods, compositions, and apparatuses are particularly useful for assisted reproduction technology (ART) procedures.

IPC Classes  ?

• C12N 5/075 - OocytesOogonia
• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61K 38/24 - Follicle-stimulating hormone [FSH]Chorionic gonadotropins, e.g. HCGLuteinising hormone [LH]Thyroid-stimulating hormone [TSH]
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

in vitro in vitro maturation of oocytes. In particular, the disclosure features methods and compositions related to engineering a plurality of ovarian support cells (OSCs) for promoting the maturation of an oocyte in a medium. Such methods and compositions are particularly useful for assisted reproduction technology (ART) procedures.

IPC Classes  ?

• C12N 5/075 - OocytesOogonia
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Goods & Services

Pharmaceutical preparations for the treatment of women's reproductive diseases and disorders. Medical research and development services in the field of women's reproductive health. Clinical medical consultation services in the field of women's reproductive health; providing information in the field of women's reproductive health; medical services in the field of women's health.

Goods & Services

Biological preparations for use in industry or science; cell culture reagents. Pharmaceutical and chemical preparations for medical treatments, such as in the field of women's health; chemical preparations for the diagnosis of medical conditions, such as in the field of women's health. Devices for the diagnosis of medical conditions, such as in the field of women's health; devices for the treatment of medical conditions, such as in the field of women's health. Cryopreservation services. Training services in the field of women's health. Scientific research and development in the field of women's health; scientific research and development consultation services; scientific testing services, such as in the field of women's health; research services relating to women's health. Medical services in the field of women's health; biomedical services, namely, in the field of women's health, including storage of human reproductive tissue, stem cells, and blood and blood components; medical consultancy services; patient treatment services; advisory services relating to women's health.

Goods & Services

Pharmaceutical preparations for the treatment of women’s reproductive diseases and disorders medical research and development services in the field of women's reproductive health Clinical medical consultation services in the field of women's reproductive health; providing information in the field of women’s reproductive health; medical services in the field of women's health.

Abstract

A platform and method for determining critical transcription factors for TF-based hiPSC differentiation. The platform including: a transcriptomic dataset database; at least a processor; a memory communicatively connected to the processor, the memory containing instructions configuring the at least a processor to generate gene regulatory networks from transcriptomic datasets; determine a candidate transcription factor; analyze an impact of the candidate transcription factor in germline cell development; and output a set of critical transcription factors.

IPC Classes  ?

• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 20/00 - Machine learning
• G16B 40/20 - Supervised data analysis
• G16B 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

A platform and method for engineering a human organoid replica for reproductive screening. The platform including an engineered reproductive cell; a detector that measures a response by the engineered reproductive cell upon exposure of the engineered reproductive cell to a stimulus; a computing device in communication with the detector wherein the computing further at least a processor; and a memory communicatively connected to the processor, the memory containing instructions configuring the at least a processor to process stimulus data received from the detector; and compare data relating to the stimulus to a user profile.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

An apparatus and method for oocyte rescue in vitro post stimulation, the apparatus including a computing device, wherein the computing device includes at least a processor; and a memory communicatively connected to the at least processor, the memory containing instructions configuring the at least processor to: receive biological sample data from a biological sample relating to a user, including at least an oocyte; determine a maturity level of the at least an oocyte; assign the at least an oocyte to a culture protocol as a function of the maturity level; receive culture data relating to the at least an oocyte as a function of the culture protocol; and calculate a scoring metric as a function of the culture data.

IPC Classes  ?

• F23R 3/10 - Air inlet arrangements for primary air
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• F01D 9/04 - NozzlesNozzle boxesStator bladesGuide conduits forming ring or sector
• F04D 29/54 - Fluid-guiding means, e.g. diffusers
• F23R 3/00 - Continuous combustion chambers using liquid or gaseous fuel

Goods & Services

Cellular reagents.

Abstract

in vitroin vitro maturation of oocytes. In particular, the disclosure features methods and compositions related to engineering a plurality of ovarian support cells (OSCs) for promoting the maturation of an oocyte in a medium. Such methods and compositions are particularly useful for assisted reproduction technology (ART) procedures.

IPC Classes  ?

• C12N 5/075 - OocytesOogonia

Goods & Services

Biological preparations for use in industry or science; cell culture reagents for scientific and research use Pharmaceutical and chemical preparations for medical treatments in the field of women's health, namely, for treating conditions of the female reproductive system; chemical preparations for the diagnosis of medical conditions in the field of women's health, namely, for the diagnosis of conditions of the female reproductive system Medical devices for the diagnosis of medical conditions in the field of women's health, namely, the diagnosis of conditions of the female reproductive system; Medical devices for the treatment of medical conditions in the field of women's health, namely, for treating conditions of the female reproductive system Cryopreservation services Training services in the field of women's health Scientific research and development in the field of women's health; scientific research and development consultation services; consultancy services in the field of research and development of medicines; scientific testing services in the field of women's health; research services relating to women's health Medical services in the field of women's health; consulting services in the field of medical care; medical analysis services relating to the treatment of patients; advisory services relating to women's health; consultancy services in the field of medicine

Abstract

An apparatus and method for inducing human oocyte maturation in vitro, the apparatus including: a computing device, wherein the computing device includes at least a processor; and a memory communicatively connected to the at least processor, the memory containing instructions configuring the at least processor to receive first biological sample data from a first biological sample relating to a user; assign the user to a stimulation protocol as a function of the first biological sample; receive second biological sample data from a second biological sample relating to the user wherein the second biological sample comprises at least an immature oocyte; receive culture data relating the second biological sample; and assign the second biological sample a scoring metric as a function of the culture data of the second biological sample.

IPC Classes  ?

• C12N 5/075 - OocytesOogonia

Goods & Services

Cellular reagents, namely ovarian support cells for promoting oocyte maturation

Abstract

in vitroin vitro fertilization and in vitro oocyte maturation.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

An implant for ovarian decline is provided. The implant includes at least an engineered ovarian support cell, an extracellular matrix substrate, and a delivery apparatus. In some embodiments, the at least an engineered ovarian support cell includes an engineered granulosa cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered lutein cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered theca cell.

IPC Classes  ?

• A61L 27/38 - Animal cells
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61L 27/24 - Collagen
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells

Abstract

Featured are compositions and methods for an ovarian implant comprising ovarian support cells. In particular, the disclosure features methods of culturing ovarian support cells for the purpose of implantation into a subject in need thereof. Additional methods for administering the OSC implant to the subject are provided. Such methods and compositions are particularly useful for assisted reproduction technology (ART) procedures and hormone replacement therapy (HRT).

IPC Classes  ?

• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61K 35/54 - OvariesOvaOvulesEmbryosFoetal cellsGerm cells
• A61P 5/26 - Androgens
• A61P 5/30 - Oestrogens
• A61P 5/34 - Gestagens
• A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells
• A61L 27/24 - Collagen
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/38 - Animal cells
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

in vitroin vitrex vivoe.ge.g., granulosa cells). Additional methods for administering follicular triggering agents and retrieving oocytes from the female subject are provided. Such methods, compositions, and apparatuses are particularly useful for assisted reproduction technology (ART) procedures.

IPC Classes  ?

• C12N 5/075 - OocytesOogonia

Abstract

An implant for ovarian decline is provided. The implant includes at least an engineered ovarian support cell an extracellular matrix substrate, and a delivery apparatus. In some embodiments, the at least an engineered ovarian support cell includes an engineered granulosa cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered lutein cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered theca cell.

IPC Classes  ?

• A61L 27/38 - Animal cells
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61L 27/24 - Collagen

Abstract

An apparatus and method for oocyte rescue in vitro post stimulation, the apparatus including a computing device, wherein the computing device includes at least a processor; and a memory communicatively connected to the at least processor, the memory containing instructions configuring the at least processor to: receive biological sample data from a biological sample relating to a user, including at least an oocyte; determine a maturity level of the at least an oocyte; assign the at least an oocyte to a culture protocol as a function of the maturity level; receive culture data relating to the at least an oocyte as a function of the culture protocol; and calculate a scoring metric as a function of the culture data.

IPC Classes  ?

• F23R 3/10 - Air inlet arrangements for primary air
• F01D 9/04 - NozzlesNozzle boxesStator bladesGuide conduits forming ring or sector
• F04D 29/54 - Fluid-guiding means, e.g. diffusers
• F23R 3/00 - Continuous combustion chambers using liquid or gaseous fuel

Goods & Services

Stem cells for medical or veterinary use; Stem cells for medical purposes Apparatus for the regeneration of stem cells for medical purposes Anatomical models for scientific, instructional, and educational purposes Stem cell research services; Chemical, biochemical, biological and bacteriological research and analysis Medical information services, namely, reporting of consumer authorized clinical testing results directly to the patient; Medical services relating to the removal, treatment and processing of stem cells; Providing information in the fields of health and wellness in the field of reproductive health via a website

Goods & Services

Transdermal patches featuring functional cells of the female reproductive system generated using proprietary methodology; Transdermal patches featuring ovarian tissue generated from stem cells; Transdermal patches for use in the treatment of delaying menopause; Transdermal patches for use in the treatment of fertility Biotechnology research; Consulting services in the field of biotechnology; Development of new technology for others in the field of biotechnology related to fertility

Goods & Services

Scientific instruments, namely, electronic analyzers for testing and analyzing chemical and biological substances for the presence, absence, or quantity of hormones and tissues related to women's reproductive health Laboratory analysis in the field of women's reproductive health; Medical laboratories; Medical laboratory services Clinical medical consultation services; Medical analysis services for diagnostic and treatment purposes provided by medical laboratories; Medical information services, namely, reporting of consumer authorized clinical testing results directly to the patient; Medical services, namely, using AI and data science to inform reproductive health services for women; Providing health information in the field of reproductive health; Providing information in the fields of health and wellness in the field of women's health and reproductive health via a website

Goods & Services

Bio-chips for research or scientific purposes; Disposable reusable dispenser syringes for laboratory use; Laboratory consumables, namely, pipette tips; Laboratory glassware; Lasers, not for medical purposes; Microscopes and parts thereof, namely, microscope stage warmers, phase contrast microscopes, dissecting microscopes, inverted stage microscopes; Microscopes and parts thereof, namely, microscopes used in gynecological procedures and medically assisted reproduction procedures; Pipette tips for laboratory use; Cell culture apparatus for laboratory use, namely, cell culture dishes; Laboratory glassware, namely, flasks Catheters; Gynecological medical instruments for examining women's reproductive organs; Lasers for medical purposes; Microscopes for surgical operations; Needles for medical purposes; Uterine probes; Injection needles for used in gynaecological procedures and medically-assisted reproduction procedures; Medical syringes; Medical fluid injectors; Medical imaging devices for embryo assessment used to analyze microscopy images of developing embryos Advertising services; Business research; Professional business consultancy; Business management consulting, strategic planning and business advisory services provided to health care professionals, namely, professional consultancy relating to health care and development of products for oocyte maturation, development of patches that secrete hormones to delay menopause and data platforms and software for drug development; Consultation in the field of procurement of goods and services Cryopreservation services Biotechnology research; Consulting services in the field of biotechnology; Development of new technology for others in the field of biotechnology relating to fertility Gynecology services; In vitro fertilization services; Medical clinic services; Medical services, namely, medical services relating to the removal, treatment and processing of stem cells; Medical services, namely, medical services relating to the removal, treatment and processing of human cells; Medical services, namely, human fertility treatment services; Medical services, namely, artificial insemination services