Abrégé

Featured are methods, compositions, and apparatuses for the in vitro maturation of oocytes. In particular, the disclosure features methods of inducing oocyte maturation in vitro, by co-culturing a female subject's oocytes with an ex vivo composition containing a plurality of ovarian support cells (e.g., granulosa cells). Additional methods for administering follicular triggering agents and retrieving oocytes from the female subject are provided. Such methods, compositions, and apparatuses are particularly useful for assisted reproduction technology (ART) procedures.

Classes IPC  ?

• C12N 5/075 - OocytesOogonies
• A61K 31/194 - Acides carboxyliques, p. ex. acide valproïque ayant plusieurs groupes carboxyle, p. ex. acides succinique, maléique ou phtalique
• A61K 38/24 - Hormone folliculostimulante [FSH]Gonadotropines chorioniques, p. ex. HCGHormone lutéinisante [LH]Hormone thyréotrope [TSH]
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs

Abrégé

in vitro in vitro maturation of oocytes. In particular, the disclosure features methods and compositions related to engineering a plurality of ovarian support cells (OSCs) for promoting the maturation of an oocyte in a medium. Such methods and compositions are particularly useful for assisted reproduction technology (ART) procedures.

Classes IPC  ?

• C12N 5/075 - OocytesOogonies
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Produits et services

Pharmaceutical preparations for the treatment of women's reproductive diseases and disorders. Medical research and development services in the field of women's reproductive health. Clinical medical consultation services in the field of women's reproductive health; providing information in the field of women's reproductive health; medical services in the field of women's health.

Produits et services

Biological preparations for use in industry or science; cell culture reagents. Pharmaceutical and chemical preparations for medical treatments, such as in the field of women's health; chemical preparations for the diagnosis of medical conditions, such as in the field of women's health. Devices for the diagnosis of medical conditions, such as in the field of women's health; devices for the treatment of medical conditions, such as in the field of women's health. Cryopreservation services. Training services in the field of women's health. Scientific research and development in the field of women's health; scientific research and development consultation services; scientific testing services, such as in the field of women's health; research services relating to women's health. Medical services in the field of women's health; biomedical services, namely, in the field of women's health, including storage of human reproductive tissue, stem cells, and blood and blood components; medical consultancy services; patient treatment services; advisory services relating to women's health.

Produits et services

Pharmaceutical preparations for the treatment of women’s reproductive diseases and disorders medical research and development services in the field of women's reproductive health Clinical medical consultation services in the field of women's reproductive health; providing information in the field of women’s reproductive health; medical services in the field of women's health.

Abrégé

A platform and method for determining critical transcription factors for TF-based hiPSC differentiation. The platform including: a transcriptomic dataset database; at least a processor; a memory communicatively connected to the processor, the memory containing instructions configuring the at least a processor to generate gene regulatory networks from transcriptomic datasets; determine a candidate transcription factor; analyze an impact of the candidate transcription factor in germline cell development; and output a set of critical transcription factors.

Classes IPC  ?

• G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 20/00 - Apprentissage automatique
• G16B 40/20 - Analyse de données supervisée
• G16B 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe

Abrégé

A platform and method for engineering a human organoid replica for reproductive screening. The platform including an engineered reproductive cell; a detector that measures a response by the engineered reproductive cell upon exposure of the engineered reproductive cell to a stimulus; a computing device in communication with the detector wherein the computing further at least a processor; and a memory communicatively connected to the processor, the memory containing instructions configuring the at least a processor to process stimulus data received from the detector; and compare data relating to the stimulus to a user profile.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

An apparatus and method for oocyte rescue in vitro post stimulation, the apparatus including a computing device, wherein the computing device includes at least a processor; and a memory communicatively connected to the at least processor, the memory containing instructions configuring the at least processor to: receive biological sample data from a biological sample relating to a user, including at least an oocyte; determine a maturity level of the at least an oocyte; assign the at least an oocyte to a culture protocol as a function of the maturity level; receive culture data relating to the at least an oocyte as a function of the culture protocol; and calculate a scoring metric as a function of the culture data.

Classes IPC  ?

• F23R 3/10 - Aménagements de l'entrée d'air pour l'air primaire
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• F01D 9/04 - InjecteursLogement des injecteursAubes de statorTuyères de guidage formant une couronne ou un secteur
• F04D 29/54 - Moyens de guidage du fluide, p. ex. diffuseurs
• F23R 3/00 - Chambres de combustion à combustion continue utilisant des combustibles liquides ou gazeux

Produits et services

Cellular reagents.

Abrégé

in vitroin vitro maturation of oocytes. In particular, the disclosure features methods and compositions related to engineering a plurality of ovarian support cells (OSCs) for promoting the maturation of an oocyte in a medium. Such methods and compositions are particularly useful for assisted reproduction technology (ART) procedures.

Classes IPC  ?

• C12N 5/075 - OocytesOogonies

Produits et services

Biological preparations for use in industry or science; cell culture reagents for scientific and research use Pharmaceutical and chemical preparations for medical treatments in the field of women's health, namely, for treating conditions of the female reproductive system; chemical preparations for the diagnosis of medical conditions in the field of women's health, namely, for the diagnosis of conditions of the female reproductive system Medical devices for the diagnosis of medical conditions in the field of women's health, namely, the diagnosis of conditions of the female reproductive system; Medical devices for the treatment of medical conditions in the field of women's health, namely, for treating conditions of the female reproductive system Cryopreservation services Training services in the field of women's health Scientific research and development in the field of women's health; scientific research and development consultation services; consultancy services in the field of research and development of medicines; scientific testing services in the field of women's health; research services relating to women's health Medical services in the field of women's health; consulting services in the field of medical care; medical analysis services relating to the treatment of patients; advisory services relating to women's health; consultancy services in the field of medicine

Abrégé

An apparatus and method for inducing human oocyte maturation in vitro, the apparatus including: a computing device, wherein the computing device includes at least a processor; and a memory communicatively connected to the at least processor, the memory containing instructions configuring the at least processor to receive first biological sample data from a first biological sample relating to a user; assign the user to a stimulation protocol as a function of the first biological sample; receive second biological sample data from a second biological sample relating to the user wherein the second biological sample comprises at least an immature oocyte; receive culture data relating the second biological sample; and assign the second biological sample a scoring metric as a function of the culture data of the second biological sample.

Classes IPC  ?

• C12N 5/075 - OocytesOogonies

Produits et services

Cellular reagents, namely ovarian support cells for promoting oocyte maturation

Abrégé

in vitroin vitro fertilization and in vitro oocyte maturation.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

An implant for ovarian decline is provided. The implant includes at least an engineered ovarian support cell, an extracellular matrix substrate, and a delivery apparatus. In some embodiments, the at least an engineered ovarian support cell includes an engineered granulosa cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered lutein cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered theca cell.

Classes IPC  ?

• A61L 27/38 - Cellules animales
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61L 27/24 - Collagène
• A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées

Abrégé

Featured are compositions and methods for an ovarian implant comprising ovarian support cells. In particular, the disclosure features methods of culturing ovarian support cells for the purpose of implantation into a subject in need thereof. Additional methods for administering the OSC implant to the subject are provided. Such methods and compositions are particularly useful for assisted reproduction technology (ART) procedures and hormone replacement therapy (HRT).

Classes IPC  ?

• A61K 35/545 - Cellules souches embryonnairesCellules souches pluripotentesCellules souches pluripotentes induitesCellules souches non caractérisées
• A61K 35/54 - OvairesOvules fécondésOvulesEmbryonsCellules fœtalesCellules germinales
• A61P 5/26 - Androgènes
• A61P 5/30 - Œstrogènes
• A61P 5/34 - Progestatifs
• A61P 15/08 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les troubles gonadiques ou pour augmenter la fertilité, p. ex. inducteurs d'ovulation ou de spermatogénèse
• C12N 5/0735 - Cellules souches embryonnairesCellules germinales embryonnaires
• A61L 27/24 - Collagène
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/38 - Cellules animales
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

in vitroin vitrex vivoe.ge.g., granulosa cells). Additional methods for administering follicular triggering agents and retrieving oocytes from the female subject are provided. Such methods, compositions, and apparatuses are particularly useful for assisted reproduction technology (ART) procedures.

Classes IPC  ?

• C12N 5/075 - OocytesOogonies

Abrégé

An implant for ovarian decline is provided. The implant includes at least an engineered ovarian support cell an extracellular matrix substrate, and a delivery apparatus. In some embodiments, the at least an engineered ovarian support cell includes an engineered granulosa cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered lutein cell. In other embodiments, the at least an engineered ovarian support cell includes an engineered theca cell.

Classes IPC  ?

• A61L 27/38 - Cellules animales
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61L 27/24 - Collagène

Abrégé

An apparatus and method for oocyte rescue in vitro post stimulation, the apparatus including a computing device, wherein the computing device includes at least a processor; and a memory communicatively connected to the at least processor, the memory containing instructions configuring the at least processor to: receive biological sample data from a biological sample relating to a user, including at least an oocyte; determine a maturity level of the at least an oocyte; assign the at least an oocyte to a culture protocol as a function of the maturity level; receive culture data relating to the at least an oocyte as a function of the culture protocol; and calculate a scoring metric as a function of the culture data.

Classes IPC  ?

• F23R 3/10 - Aménagements de l'entrée d'air pour l'air primaire
• F01D 9/04 - InjecteursLogement des injecteursAubes de statorTuyères de guidage formant une couronne ou un secteur
• F04D 29/54 - Moyens de guidage du fluide, p. ex. diffuseurs
• F23R 3/00 - Chambres de combustion à combustion continue utilisant des combustibles liquides ou gazeux

Produits et services

Stem cells for medical or veterinary use; Stem cells for medical purposes Apparatus for the regeneration of stem cells for medical purposes Anatomical models for scientific, instructional, and educational purposes Stem cell research services; Chemical, biochemical, biological and bacteriological research and analysis Medical information services, namely, reporting of consumer authorized clinical testing results directly to the patient; Medical services relating to the removal, treatment and processing of stem cells; Providing information in the fields of health and wellness in the field of reproductive health via a website

Produits et services

Transdermal patches featuring functional cells of the female reproductive system generated using proprietary methodology; Transdermal patches featuring ovarian tissue generated from stem cells; Transdermal patches for use in the treatment of delaying menopause; Transdermal patches for use in the treatment of fertility Biotechnology research; Consulting services in the field of biotechnology; Development of new technology for others in the field of biotechnology related to fertility

Produits et services

Scientific instruments, namely, electronic analyzers for testing and analyzing chemical and biological substances for the presence, absence, or quantity of hormones and tissues related to women's reproductive health Laboratory analysis in the field of women's reproductive health; Medical laboratories; Medical laboratory services Clinical medical consultation services; Medical analysis services for diagnostic and treatment purposes provided by medical laboratories; Medical information services, namely, reporting of consumer authorized clinical testing results directly to the patient; Medical services, namely, using AI and data science to inform reproductive health services for women; Providing health information in the field of reproductive health; Providing information in the fields of health and wellness in the field of women's health and reproductive health via a website

Produits et services

Bio-chips for research or scientific purposes; Disposable reusable dispenser syringes for laboratory use; Laboratory consumables, namely, pipette tips; Laboratory glassware; Lasers, not for medical purposes; Microscopes and parts thereof, namely, microscope stage warmers, phase contrast microscopes, dissecting microscopes, inverted stage microscopes; Microscopes and parts thereof, namely, microscopes used in gynecological procedures and medically assisted reproduction procedures; Pipette tips for laboratory use; Cell culture apparatus for laboratory use, namely, cell culture dishes; Laboratory glassware, namely, flasks Catheters; Gynecological medical instruments for examining women's reproductive organs; Lasers for medical purposes; Microscopes for surgical operations; Needles for medical purposes; Uterine probes; Injection needles for used in gynaecological procedures and medically-assisted reproduction procedures; Medical syringes; Medical fluid injectors; Medical imaging devices for embryo assessment used to analyze microscopy images of developing embryos Advertising services; Business research; Professional business consultancy; Business management consulting, strategic planning and business advisory services provided to health care professionals, namely, professional consultancy relating to health care and development of products for oocyte maturation, development of patches that secrete hormones to delay menopause and data platforms and software for drug development; Consultation in the field of procurement of goods and services Cryopreservation services Biotechnology research; Consulting services in the field of biotechnology; Development of new technology for others in the field of biotechnology relating to fertility Gynecology services; In vitro fertilization services; Medical clinic services; Medical services, namely, medical services relating to the removal, treatment and processing of stem cells; Medical services, namely, medical services relating to the removal, treatment and processing of human cells; Medical services, namely, human fertility treatment services; Medical services, namely, artificial insemination services