Abstract

FNDC1, COL3A1, CX3CR1, SLC16A5, EPM2A, SLC35B3, PRTFDC1, CSRNP2, CCL16, HOXB4, GVINP1, LOC339874, MTRNR2L1LOC148709LOC148709, as an active ingredient.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
• G01N 30/72 - Mass spectrometers

Abstract

The present invention relates to a cyclic iRGD-conjugated lipid nanoparticle composition with improved blood-brain barrier permeability and a drug carrier comprising same. More specifically, the present invention provides a cyclic iRGD-conjugated lipid nanoparticle composition that targets αvβ3 and αvβ5 integrins, which are abundant in tumor vasculature at the blood-brain barrier, by preparing lipid nanoparticles comprising cyclic iRGD-conjugated lipids so as to enhance drug delivery to lesion sites in the brain. Furthermore, using in vitro blood-brain barrier model experiments, it was confirmed that more cyclic iRGD-conjugated lipid nanoparticles were detected in glioblastoma than the control group and R-iRGD-conjugated lipid nanoparticles, better cellular uptake occurred, drug loading rate improved as total lipid capacity increased, and a larger amount of drug was released under conditions similar to a living body. Therefore, the cyclic iRGD-conjugated lipid nanoparticle composition with improved blood-brain barrier permeability according to the present invention and the drug carrier comprising same are expected to achieve excellent preventive and therapeutic effects in various brain diseases.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

One aspect of an embodiment of the present invention may provide a multipurpose device for monitoring an infant health condition, the device comprising: a head part having one surface on which a gripping part configured to be gripped by an infant's hand is formed, and the other surface on which a contact part is formed, the contact part being configured to be in direct contact with the infant's body to measure a biosignal or having an inwardly recessed central groove or an edge groove formed on the periphery thereof so as to be coupled to a nipple part; a sensor part provided on the head part to measure a biosignal of an infant at play; and a control part for determining the health condition of the infant on the basis of the measured biosignal. Accordingly, the health condition of an infant, including body temperature, pulse, oxygen saturation, electrical conductivity of the skin, and pressure, can be determined through multiple channels and can be transmitted to an external device, thereby monitoring the health condition of the infant.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/0533 - Measuring galvanic skin response

Abstract

2233 layer) formed on the silicon dioxide layer.

IPC Classes  ?

• G01N 3/307 - Investigating strength properties of solid materials by application of mechanical stress by applying a single impulsive force generated by a compressed or tensile-stressed springInvestigating strength properties of solid materials by application of mechanical stress by applying a single impulsive force generated by pneumatic or hydraulic means
• G01N 3/12 - Pressure-testing

Abstract

According to a prostate cancer diagnosis system and method for predicting prostate cancer by digitally converting tactile sensations of a user, as proposed in the present invention, the prostate cancer diagnosis system comprises: a prostate cancer measurement device that images tactile sensations by using electrodes applied according to changes in elasticity of prostate tissues to which pressure is applied; and a mobile device that receives numerical data about imaged prostate tactile sensations from the prostate cancer measurement device, analyzes the presence of tissues on the basis of the numerical data about the prostate tactile sensations, diagnoses prostate cancer through a result of analyzing the numerical data, and outputs the diagnosis. Thus, by using a small tactile sensor, prostate cancer can be palpated and early-stage prostate nodules can be easily diagnosed without relying on experts.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

According to an embodiment of the present invention, a method for predicting an early neurological deterioration (END) of a patient by using a plurality of artificial intelligence models may be provided, the method comprising the steps of: acquiring an original brain image and clinical information of the patient from a server; outputting a lesion image of the original brain image by inputting the original brain image into a first artificial intelligence model that performs lesion analysis on a brain image; outputting a first probability value, which is a probability of occurrence of the END of the patient, by inputting the original brain image and the lesion image into a second artificial intelligence model; outputting a second probability value, which is a probability of occurrence of the END of the patient, by inputting the clinical information into a third artificial intelligence model; and on the basis of the first probability value and the second probability value, calculating a final probability value that is a probability of occurrence of the END of the patient.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention relates to a marker composition for the diagnosis or prognosis prediction of non-alcoholic fatty liver disease and a diagnosis method using same. The inventors of the present invention confirmed that the expression level of a lipocalin-2 gene or a protein encoded thereby was increased in samples from patients with non-alcoholic fatty liver disease and/or liver fibrosis, and when this is used, non-alcoholic fatty liver disease and/or liver fibrosis can be accurately and rapidly diagnosed.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Provided is a hybrid ring-type smart stethoscope and a method for producing the same, and the hybrid ring-type smart stethoscope includes: a connection part which has a hollow hole into which a user's finger is inserted; an upper structure which is provided on the top of the connection part; and a lower structure which is provided on the bottom of the connection part, and has a measurement module collecting body-related information, which includes the user's heartbeat or respiratory information, by coming into contact with the user. The method of producing a hybrid ring-shaped smart stethoscope includes the steps of: preparing a connection part for wearing on a user's finger; installing an upper structure on the top of the connection part in a foldable manner; and installing a lower structure on the bottom of the connection part in a foldable manner. Therefore, the hybrid ring-type smart stethoscope can effectively auscultate a user's pulse and cardiopulmonary sounds, and is conveniently portable on an ordinary day.

IPC Classes  ?

• A61B 7/04 - Electric stethoscopes
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 7/00 - Instruments for auscultation

Abstract

The present invention provides a depth data-based pressure ulcer diagnosis system and method using a multispectral light source, the system comprising: a light emission unit for irradiating the skin of a body part with light in order to diagnose a pressure ulcer; a measurement unit which measures light transmittance using reflected light that is reflected from the skin of the body part when the skin of the body part is irradiated with light in order to diagnose a pressure ulcer; and a pressure ulcer diagnosis unit which diagnoses the condition of a pressure ulcer on the basis of the light transmittance measured by the measurement unit, wherein the optical principle that the transmittance of light from a multispectral light source through the skin differs according to wavelength can be used to detect skin abnormalities caused by pressure ulcers.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

The present invention provides a device for measuring glycated hemoglobin measurement using carbon electrodes, a biosensor for simultaneous measurement of glucose and glycated hemoglobin, using same, and a method for simultaneous measurement of glucose and glycated hemoglobin, using the biosensor, wherein the biosensor includes a first measurement electrode, formed on the surface of a measuring part compartmentalized on a base substrate, for measuring a blood glucose level with a single drop of a sample introduced into the measuring part, and a second measurement electrode, formed around the first measurement electrode, for measuring a blood glycated hemoglobin level with a single drop of the sample introduced into the measuring part, whereby the sensor allows for the simultaneous measurement of blood glucose and glycated hemoglobin levels with a single drop of sample, offering a cheaper and simpler measurement method than conventional ones, enables the collection of both short and long-term information about a patient's blood sugar status due to the simultaneous measurement of blood glucose and glycated hemoglobin levels, and is capable of faster measurement compared to conventional sensors, with adequate sensitivity, selectivity, and efficiency suitable for monitoring fluctuations in a patient's blood sugar.

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/327 - Biochemical electrodes
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin

Abstract

The present specification relates to a composition for external application on the skin for radiation protection, and a method for preparing same. According to the present disclosure, the composition can directly protect the skin by comprising a body-friendly radiation shielding material, and can be useful in the field since it is possible to control the specific amount used to prevent radiation exposure. According to the present disclosure, the radiation shielding material is uniformly dispersed in the composition, is long lasting, and has excellent formulation stability even when stored for a long period of time. Therefore, the composition of the present disclosure can be useful in various industrial fields that require radiation shielding performance, such as medicine and construction.

IPC Classes  ?

• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 33/10 - CarbonatesBicarbonates
• A61K 33/22 - Boron compounds
• A61K 33/245 - BismuthCompounds thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 17/16 - Emollients or protectives, e.g. against radiation

Abstract

The present invention relates to a method for manufacturing a novel lightweight radiation shield by creating a pattern of a multi-layer thin film structure of a Morpho butterfly wing by electrospinning a polymer composite material. According to the present invention, it is possible to provide lightweight shielding paper that exhibits excellent shielding performance even when made of an eco-friendly shielding material rather than lead, which is a dangerous material. The shielding paper can be laminated and thereby usefully used in medical radiation shielding suits requiring mobility, as well as various other industrial fields.

IPC Classes  ?

• G21F 1/12 - Laminated shielding materials

Abstract

A lipocalin 2 Inhibitor of the present invention can exhibit the effects of preventing and treating liver fibrosis by inhibiting the induction of liver cells into hepatic stellate cells through the inhibition of lipocalin 2 expression, and thus a pharmaceutical composition comprising same is expected to be used in therapeutic agents and the like for exhibiting excellent treatment effects on liver fibrosis.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A23L 33/13 - Nucleic acids or derivatives thereof

Abstract

Proposed are a non-contact image-based blood pressure measurement method and system based on advanced visual intelligence, wherein a blood pressure measurement model is created by performing neural network training with an image sequence obtained by a webcam in a non-contact manner, and the blood pressure of a measurement subject is estimated with the blood pressure measurement model. Accordingly, since the webcam for obtaining a video, that is, an image sequence, in a non-contact manner is used, blood pressure is continuously estimated during the recording with the webcam without contact with a device or another person, and blood pressure is estimated just by being in front of the webcam, so the system is easy to use, inexpensive, and secures sufficient precision by using a neural network algorithm.

IPC Classes  ?

• A61B 5/026 - Measuring blood flow
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/021 - Measuring pressure in heart or blood vessels
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/60 - Extraction of image or video features relating to illumination properties, e.g. using a reflectance or lighting model
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

This stone analysis method for a urinary stone patient comprises steps in which an analysis device: receives clinical information about the urinary stone patient together with a three-dimensional computed tomography (CT) image of the urinary stone patient; segments stones in the three-dimensional CT image by using a critical value; calculates a variant coefficient of stone density (VCSD) from the segmented stones; and determines whether the stones of the patient are uric acid stones on the basis of the VCSD and the clinical information about the urinary stone patient.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• A61B 6/12 - Arrangements for detecting or locating foreign bodies
• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention relates to a method for manufacturing a Fe-xSi(x=4-10.0wt%) alloy compressed powder core by high-temperature molding and a high-temperature molded, Fe-xSi(x=4-10.0wt%) alloy compressed powder core manufactured by the manufacturing method, the method comprising: (a) a coating step of coating a metal alloy powder with an insulator (coating agent), (b) a lubricant mixing step of mixing a lubricant with the metal alloy powder coated with the insulator (coating agent), (c) a primary molding step of primarily molding the coated metal alloy powder at room temperature, (d) a secondary molding step of secondarily molding the coated metal alloy powder at a high temperature, and (e) a heat treatment step, whereby the alloy compressed powder core is higher in molding density and permeability and lower in iron loss compared to those manufactured by conventional room temperature molding methods.

IPC Classes  ?

• H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
• B22F 1/16 - Metallic particles coated with a non-metal
• B22F 1/12 - Metallic powder containing non-metallic particles
• B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
• B22F 9/00 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor
• C22C 1/11 - Making amorphous alloys

Abstract

The present specification relates to a radiation-shielding film and a manufacturing method therefor. According to the present disclosure, an eco-friendly radiation-shielding film that is manufacturable at low cost can be provided by comprising an eco-friendly radiation-shielding material and employing waste plastics, as a polymer base to be mixed with the shielding material. The present disclosure exhibits excellent radiation-shielding performance even through manufactured with a thin thickness, by improving the mixability of a radiation-shielding material and waste plastics, and thus can be helpfully used for various products and in various industrial fields requiring radiation-shielding films, such as medical or construction fields.

IPC Classes  ?

• G21F 1/10 - Organic substancesDispersions in organic carriers
• B29B 17/02 - Separating plastics from other materials
• B29D 7/01 - Films or sheets
• B29B 17/04 - Disintegrating plastics
• C08J 5/18 - Manufacture of films or sheets
• C08L 101/00 - Compositions of unspecified macromolecular compounds
• C08K 3/08 - Metals
• C08K 3/22 - OxidesHydroxides of metals
• C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds

Abstract

The present invention relates to a composition that substitutes for fetal bovine serum (FBS). More specifically, the composition includes an insect protein hydrolysate for use in cell cultures and when used for various animal-derived cell cultures, including human, has been confirmed to have the effects on cell growth which are equivalent or even superior to those when FBS is included while enabling a reduction in the usage of FBS, which is both costly and presents ethical issues. Therefore, the composition with the insect protein hydrolysate can be used as a substitute for fetal bovine serum and can find advantageous applications in cultured meat and various food industries that use same as an ingredient as well as in cell cultures of the bio-sector.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
• C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Abstract

A single-port laparoscopic surgical robot according to an embodiment of the present invention comprises: a plurality of surgical arms of which the angles and heights are controlled; and a surgical module which is installed on one or two or more surgical arms among the plurality of surgical arms, and performs surgery by penetrating a retractor inserted into a patient's abdomen, wherein the surgical module includes a surgical frame on which surgical devices are installed at an end, and linkages frame coupled to the surgical arms and transmitting power to the surgical device provided on the surgical frame, and the linking frames are bent in opposite outward directions to prevent interference between the linking frames operating outside the patient's abdomen, thereby making it possible to minimize interference between surgical devices that occurs during surgery.

IPC Classes  ?

• A61B 34/35 - Surgical robots for telesurgery
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors
• A61B 34/30 - Surgical robots

Abstract

22); preparing a first mixture comprising the modified silicon nanoparticles, carbon nanofibers, and citric acid; manufacturing an assembly by electrostatically self-assembling the first mixture and graphene oxide (GO); preparing an intermediate by hydrothermally synthesizing a second mixture comprising the assembly, melamine, and formaldehyde resin; and calcining the intermediate.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• C01B 33/02 - Silicon
• C01B 32/158 - Carbon nanotubes
• C01B 32/168 - After-treatment
• C01B 32/194 - After-treatment
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

The present invention relates to a titanium oxide phase change producing apparatus, system and method, using the number of shock wave exposures, a handy shock wave tube device, and a system and method for testing material characteristics comprising same. An embodiment of the present invention provides a titanium oxide phase change producing apparatus using the number of shock wave exposures, the titanium oxide phase change producing apparatus comprising: a shock wave tube that is formed as a tube having a circular or polygonal cross section and is capable of measuring the impact of shock waves; and a test model that is disposed at the other end of the shock wave tube to form an end wall and has an anatase titanium dioxide nanoparticle sample attached to one side so that a phase change occurs according to the number of shock wave exposures. Another embodiment of the present invention provides a handy shock wave tube device comprising: a shock wave tube which is formed as a tube having a circular or polygonal cross section and is capable of measuring the impact of shock waves; a pressure part that supplies gas to the shock wave tube to apply pressure thereto; and a driver that drives parts of the shock wave tube to be separated and coupled.

IPC Classes  ?

• G01M 9/06 - Measuring arrangements specially adapted for aerodynamic testing
• G01M 9/04 - Wind tunnels Details
• G01N 3/12 - Pressure-testing
• G01N 3/30 - Investigating strength properties of solid materials by application of mechanical stress by applying a single impulsive force
• G01L 19/08 - Means for indicating or recording, e.g. for remote indication

Abstract

The present invention proposes a device and method for restoring digital pathology staining by using a GAN. The device comprises: a generation network for generating similar false data on the basis of original data which is actual learning data; and a determination network for using and learning the false data generated from the generation network, and original data which is actual learning data and determining whether data input thereto is the actual learning data or the false data. Therefore, among staining data produced currently, data that is unusable due to loss of staining can be digitally restored to its original state.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06N 3/08 - Learning methods
• G06N 3/04 - Architecture, e.g. interconnection topology
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 1/30 - StainingImpregnating

Abstract

The present application relates to a radiation shielding film using tungsten powder and a preparation method for the radiation shielding film. The radiation shielding film is prepared in the form of an ultra-thin film while still including tungsten particles at high density, as eco-friendly radiation shielding materials that replace lead, and thus may be excellent in both flexibility and radiation shielding ratio, thereby being usefully applicable in radiation shielding suits for medical institutions as well as in various fields requiring radiation shielding films. The radiation shielding film includes tungsten powder and a polymer base, wherein the tungsten powder has an average particle size of 80-200 nm, and the film has a thickness of 0.1-0.025 mm.

IPC Classes  ?

• G21F 1/10 - Organic substancesDispersions in organic carriers
• G21F 1/12 - Laminated shielding materials
• C08J 5/18 - Manufacture of films or sheets
• C08K 3/08 - Metals
• C08L 101/00 - Compositions of unspecified macromolecular compounds

Abstract

The present invention relates to novel PIM kinase inhibitors and uses thereof and, more specifically, to a novel compound having PIM kinase inhibitory activity and a composition for the prevention, amelioration or treatment of diseases related to PIM kinase activity, comprising same. The compound of the present invention was confirmed to have effective PIM kinase inhibitory activity while having low cardiotoxicity, and thus can be effectively used as a composition for the prevention, amelioration or treatment of various diseases related to PIM kinase activity, such as cancer, autoimmune diseases, myeloproliferative disorders, or atherosclerosis.

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
• A61P 35/00 - Antineoplastic agents
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

The present invention relates to a smart infant stethoscope and an infant health status monitoring system including same, the smart infant stethoscope comprising: insertion portions that have rubber caps coupled to the outside thereof and are inserted into the ears; a head portion having, on one side thereof, a gripping portion that is held by the hand and, on the other side, a contact portion which comes into contact with the body; sensor units provided in the insertion portions and the head portion to measure biological signals of an infant at play; and a control unit that assesses the health condition of the infant on the basis of the measured biological signals. Accordingly, the health status of infants, including body temperature, pulse waves, oxygen saturation, and skin conductance, can be assessed through multiple channels and be transferred to an external device, so that the health status of infants can be monitored.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/0533 - Measuring galvanic skin response
• A63H 33/30 - Imitations of apparatus, not otherwise provided for, e.g. telephones, weighing-machines or cash-registers
• A61N 5/06 - Radiation therapy using light

Abstract

The present invention relates to a biomarker for the diagnosis of pre-diabetes and diabetes, and a use thereof, and more specifically, to: a composition and a kit for the diagnosis of pre-diabetes or diabetes, the composition and kit comprising an agent for measuring the expression level of at least one selected from among four piRNAs; and a method for diagnosing pre-diabetes or diabetes by using the marker. The present inventors analyzed the expression level of piRNA contained in exosomes isolated from the blood of a normal group, a pre-diabetic patient group, and a diabetic patient group, and thus, found four piRNA (hsa-piR-31447, hsa-piR-33226, hsa-piR-36246, and hsa-piR-49124) markers capable of distinguishing the normal group, the pre-diabetic patient group, and the diabetic patient group. Also, it was confirmed that using the four piRNA markers makes it possible to diagnose pre-diabetes and/or diabetes accurately and rapidly, and thus the piRNA can be effectively used as a biomarker for the diagnosis of pre-diabetes and/or diabetes.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

The present invention relates to a blockchain data storage method performed by a blockchain data storage management device for storing data by using a blockchain, comprising steps in which: a plurality of nodes included in a blockchain network is clustered by service so as to generate service-specific groups; blockchain nodes included in the service-specific groups are designated as specific nodes on the basis of a predetermined condition; the specific nodes generate a block on the basis of a transaction when the transaction is received from a service user; and blockchain data based on the block is stored in local storage possessed by blockchain nodes included in the service-specific groups. Therefore, latency time and data reliability are ensured by maintaining asynchronously through the local storage maintained in the blockchain node, data stored in the blockchain is stored in the storage divided by service, and a synchronization transaction is generated through a method of agreeing before storing, by node, data in the local storage, and thus reliability can be guaranteed.

IPC Classes  ?

• H04L 67/1097 - Protocols in which an application is distributed across nodes in the network for distributed storage of data in networks, e.g. transport arrangements for network file system [NFS], storage area networks [SAN] or network attached storage [NAS]
• H04L 67/1042 - Peer-to-peer [P2P] networks using topology management mechanisms
• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols

Abstract

An embodiment of the present invention relates to a virtual collaboration non-contact real-time remote experimental system. An embodiment of the present invention provides a virtual collaboration non-contact real-time remote experimental system comprising: a virtual reality (VR) headset that is carried by a user, captures an image of the user to obtain user image information, and displays an avatar generated using the user image information and virtual reality contents for a non-contact real-time remote experiment; and a metaverse platform server that generates the avatar and the virtual reality contents and provides same to the VR headset, and controls implementation and/or operation of the virtual reality contents on the basis of input information of the user which is received from the VR headset.

IPC Classes  ?

• G06Q 10/10 - Office automationTime management
• G02B 27/01 - Head-up displays
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition
• G06T 13/40 - 3D [Three Dimensional] animation of characters, e.g. humans, animals or virtual beings
• G06T 3/40 - Scaling of whole images or parts thereof, e.g. expanding or contracting
• G01P 1/07 - Indicating devices, e.g. for remote indication

Abstract

A method for classifying a uric acid content of a urinary stone by using a radiomics parameter comprises the steps of: receiving, by an analysis device, a CT image of a subject; segmenting, by the analysis device, a region of a urinary stone from the CT image; extracting, by the analysis device, radiomics parameters from the region of the urinary stone; and classifying, by the analysis device, an uric acid component of the urinary stone, on the basis of a value calculated by inputting the radiomics parameters into a pretrained learning model.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• A61B 6/12 - Arrangements for detecting or locating foreign bodies
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention provides a fluorometric assay substrate for the simultaneous measurement of glucose and lactate, wherein an identical substrate (Amplex Red) that reacts with glucose and lactate and a catalyst (horseradish peroxidase: HRP) are used such that the setting of protocols for assaying both glucose and lactate is convenient, an assay procedure for measuring glucose and lactate can be simplified, the concentrations of glucose and lactate are measured simultaneously, thus making the measuring of glucose and lactate concentration convenient, and the measured concentrations of glucose and lactate can be used to measure obesity and embryonic activity more precisely than in the prior art.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• C12Q 1/28 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase involving peroxidase
• C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The present invention relates to a smart stethoscope, comprising: a main body including a plurality of sensors for measuring a user's bio-signals and a power supply unit; and a fixing part coupled to the front surface of the main body and provided to be foldable to fix a user's finger, wherein the main body includes: an input unit operated by a user; and a control unit that, when one of measurement modes is selected by the user's operation, measures a bio-signal at a specific sensor from among the plurality of sensors on the basis of the selected measurement mode, and calculates a measurement value corresponding to the measured bio-signal according to a preset algorithm. Accordingly, auscultation can be optimized for a user by changing a measurement frequency by changing the mode according to the user while allowing for auscultation through multi-channels including electrocardiogram, pulse waves, and heart and lung sounds.

IPC Classes  ?

• A61B 7/04 - Electric stethoscopes
• A61B 7/00 - Instruments for auscultation
• A61B 5/28 - Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention provides a method for preparing porous silica and porous silica prepared thereby, the method comprising: (a) adding, to distilled water, water glass (sodium silicate solution) as a silica precursor, followed by stirring; (b) adding a surfactant to a water glass solution formed in step (a), followed by stirring; (c) adding an acidic solution to a surfactant-added solution formed in step (b), followed by stirring, to adjust pH; and (d) performing a room-temperature reaction for a predetermined time, filtration, and then washing, thereby synthesizing porous silica.

IPC Classes  ?

• C01B 33/193 - Preparation of finely divided silica neither in sol nor in gel formAfter-treatment thereof by acidic treatment of silicates of aqueous solutions of silicates

Abstract

According to an EfficientNet architecture-based mobile vision system and method enabling prediction of a human's complex emotion proposed in the present invention, the system may comprise: a biosignal measurement unit for measuring a biosignal of a subject of which the emotion state is to be predicted; an image measurement unit for measuring a facial expression image of the subject of which the emotion state is to be predicted; and an emotion prediction unit that analyzes the biosignal measured by the biosignal measurement unit and the facial expression image measured by the image measurement unit to classify respective emotions, and combines the classified emotions of the biosignal and the facial expression image to predict a final emotion, thereby predicting an emotion state from a combination of a biosignal and a facial expression image of a subject rather than using only a facial expression image, so as to provide higher accuracy and maintain high recognition performance with optimal parameters.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
• A61B 5/346 - Analysis of electrocardiograms
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/026 - Measuring blood flow
• A61B 5/021 - Measuring pressure in heart or blood vessels
• G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions

Abstract

The present invention provides a biosensor for the simultaneous measurement of glucose and lactate, the biosensor comprising: a base on a plate; a first reaction electrode unit that is formed on one side of the upper surface of the base, and reacts with a whole blood sample to emit electrons according to the concentration of glucose contained in the whole blood; a second reaction electrode unit that is formed adjacent to the first reaction electrode unit on the upper surface of the base, and reacts with the whole blood sample to emit electrons according to the concentration of lactate contained in the whole blood; a counter electrode unit which is formed on the upper surface of the base and around the first reaction electrode unit and the second reaction electrode unit, and through which electricity applied to the first reaction electrode unit and the second reaction electrode unit selectively flows; and an insulating cover bonded to the upper surface of the base and exposing the first reaction electrode unit, the second reaction electrode unit, and the counter electrode unit to the outside through a hole formed on one side, wherein a single drop of the whole blood sample is used to simultaneously measure the concentrations of glucose and lactate.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
• C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
• G01N 33/483 - Physical analysis of biological material

Abstract

The present specification relates to a radiation shielding fiber using tungsten powder and a method for preparing the radiation shielding fiber, wherein tungsten particles, an eco-friendly radiation shielding material replacing lead, are directly and uniformly sprayed and coated on a base fiber, so both flexibility and radiation shielding rate are excellent, making it easy to use in various fields that require radiation shielding fibers other than radiation shielding clothing for medical institutions. The radiation shielding fiber according to the present invention includes a base fiber and a radiation shielding material coating layer coated on one surface of the base fiber, wherein the radiation shielding material coating layer is made of a mixture of tungsten powder and at least one inorganic material selected from tin and cobalt.

IPC Classes  ?

• G21F 1/08 - MetalsAlloysCermets, i.e. sintered mixtures of ceramics and metals
• G21F 3/02 - Clothing

Abstract

According to a perfusion imaging-based non-contact autonomic nervous system response multi-dimensional bio-signal measurement system and method proposed in the present invention, the present invention comprises: a light source unit for irradiating a light source outside a visible light region and measuring a multi-dimensional bio-signal in a non-contact manner; a multi-dimensional multi-spectral camera for photographing amplified reflected light irradiated from the light source unit and then reflected and generating an image sequence of the bio-signal according to the amplified reflected light; and a measurement diagnosis unit for measuring heart rate, oxygen saturation, blood flow per second, and blood pressure through image processing of the image sequence of the bio-signal generated from the multi-dimensional multi-spectral camera through photographing, thus being able to overcome the limitations of existing individual bio-signal measurement systems, increase the accuracy of bio-signal measurement and diagnosis through image processing excluding noise observed in a visible region, and further improve the efficiency and convenience of multidimensional bio-signal measurement.

IPC Classes  ?

• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/026 - Measuring blood flow
• A61B 5/021 - Measuring pressure in heart or blood vessels

Abstract

The present specification relates to a fiber for radiation-shielding functional clothing, and a manufacturing method therefor, and the fiber having a radiation-shielding ability and being harmless to the human body, thereby effectively protecting the body from radiation. In addition, since a radiation-shielding material is included on the inside, and not the outside, of the filament, the fiber exhibits high strength while having flexibility, breathability and lightness that are similar to those of a normal fiber, and thus is combined with additional elements such as zippers, hooks and rubber so as to be used in the manufacturing of various forms of radiation-protective functional clothing such as underwear, jackets or scarves.

IPC Classes  ?

• A41B 9/00 - Undergarments
• G21F 3/02 - Clothing
• D03D 1/00 - Woven fabrics designed to make specified articles
• D03D 11/00 - Double or multi-ply fabrics not otherwise provided for
• D03D 15/283 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads synthetic polymer-based, e.g. polyamide or polyester fibres
• D01F 1/10 - Other agents for modifying properties
• D01D 5/08 - Melt-spinning methods
• D03D 15/50 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads

Abstract

A multi-object tracking device and method based on self-supervised learning proposed in the present invention is the first attempt to apply self-supervised learning to online multi-object tracking, applies a pose normalized GAN (PN-GAN) and image augmentation for learning considering an object's pose change, can design a MOT model generating a better result even with a less number of pieces of data by resolving the problem of lack of learning data through the PN-GAN, can generate more discrimination feature vectors during learning of an encoder network by proposing an affinity correlation distance (ACD) that is a new loss function, can learn using an end-to-end scheme, can be directly applied without additional transfer learning because additional fine tuning for classification, clustering, and regression is not required, and can take up less memory than other latest methods and provide fast and high tracking performance.

IPC Classes  ?

• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06T 7/187 - SegmentationEdge detection involving region growingSegmentationEdge detection involving region mergingSegmentationEdge detection involving connected component labelling
• G06N 20/00 - Machine learning

Abstract

The present invention relates to a composition capable of distinguishing a patient suffering from ankylosing spondylitis, from rheumatic disease patients by confirming the expression of caspase-1 in a serum sample. By confirming the expression level of caspase-1 in serum, the composition of the present invention can distinguish ankylosing spondylitis from rheumatic diseases. Since only ankylosing spondylitis can be significantly diagnosed, the present invention is expected to help establish a treatment strategy for ankylosing spondylitis at an early stage.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a single embryo culture system using sound wave control. The single embryo culture system using sound wave control, according to the present invention, comprises: a substrate which is plated with a conductor; a polymer chamber in which a culture space for culturing a single embryo is formed, implemented in an open polygonal shape, and attached to the substrate; at least one pair of electrodes which are located at symmetric points on the basis of the polymer chamber and are attached to the substrate; and a sound wave control unit which generates sound waves to a single embryo present in the polymer chamber, through the at least one pair of electrodes when a voltage is applied thereto. Thus, according to the present invention, the embryo is cultured in an environment similar to living conditions by controlling the movement of the embryo to be induced using sound waves, thereby improving the success rate of in vitro fertilization.

IPC Classes  ?

• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12N 5/073 - Embryonic cells or tissuesFoetal cells or tissues
• C12N 13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

Abstract

An electronic apparatus according to a disclosed aspect comprises: an electrode sensor which applies a current to an object and measures the impedance of the object; a frequency controller which adjusts the frequency of the applied current; a memory which stores a correlation between impedance and vitamin D concentration for each frequency; and a processor which, while varying the frequency, obtains the impedance of the object, identifies the correlation to which the obtained impedance belongs, and calculates a vitamin D concentration of the object on the basis of the correlation.

IPC Classes  ?

• A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Disclosed herein is an electronic apparatus. The electronic apparatus includes an electrode sensor configured to apply a current to an object and configured to measure an impedance of the object, a frequency controller configured to adjust a frequency of the applied current, a memory storing a correlation between an impedance and a vitamin D concentration for each frequency, and a processor configured to obtain the impedance of the object corresponding to the frequency, and to calculate a vitamin D concentration of the object based on the impedance and the correlation.

IPC Classes  ?

• A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content

Abstract

In a system and a method for providing an artificial intelligence-based surgery result report using a speech recognition platform, for a surgery result report written by hand after surgery, a surgery procedure and a surgery diagnosis result are input using artificial intelligence-based speech recognition and in response thereto, a surgery result report is automatically generated. According to the present invention, a surgery procedure and a diagnosis result can be input using speech recognition, inaccuracy of input value recognition according to pronunciation can be prevented by a response selection signal configured by a number, and the convenience and accuracy in generation of a surgery result report can be enhanced.

IPC Classes  ?

• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G10L 15/26 - Speech to text systems
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning
• G06F 16/332 - Query formulation
• G06F 40/30 - Semantic analysis
• G06F 16/35 - ClusteringClassification

Abstract

The present invention relates to a novel inhibitor for multiple protein kinases, and provides: a novel indolin-2-one compound or a pharmaceutically acceptable salt thereof that exhibits excellent anti-inflammatory activity; and a composition for treating inflammatory diseases, containing same as an active ingredient. The novel compound strongly inhibits the activity of various protein kinases related to inflammation, and thus can be used as an inhibitor for multiple protein kinases, and has an excellent anti-inflammatory effect as compared to other anti-inflammatory drugs, and thus can be used in the development of therapeutic agents for inflammatory diseases.

IPC Classes  ?

• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention provides a blockchain-based composing device and a control method therefor, and a computer program stored in a computer-readable recording medium. The blockchain-based composing device of the present invention comprises: an input module for receiving musical elements for composing; an output module for playing and outputting a sound source according to music information; a memory for storing the music information about the composed sound source; a communication module for connecting to a blockchain network; and a processor, which generates the music information according to the musical elements inputted through the input module so as to store the music information in the memory, plays back the sound source through the output module according to the generated music information, and receives copyright information of a composer if initial music information is to be generated for composing, so as to connect to the blockchain network through the communication module, and thus record copyright information and the music information on a blockchain during composing.

IPC Classes  ?

• G10H 1/00 - Details of electrophonic musical instruments
• G06F 21/10 - Protecting distributed programs or content, e.g. vending or licensing of copyrighted material
• G06Q 50/18 - Legal services
• G06Q 50/10 - Services
• H04L 67/1097 - Protocols in which an application is distributed across nodes in the network for distributed storage of data in networks, e.g. transport arrangements for network file system [NFS], storage area networks [SAN] or network attached storage [NAS]

Abstract

An embodiment wireless charging vehicle includes a secondary charging pad configured to generate an induced current by a magnetic field generated to a primary charging pad of a wireless charging station and to charge a battery, a plurality of ultra-wideband (UWB) tags disposed to surround the vehicle, and a UWB controller configured to perform a wireless charging arrangement mode for arranging the secondary charging pad on the primary charging pad by using a sensor value measured by the UWB tags, wherein the UWB controller is configured to calculate a coordinate of the primary charging pad by using a line of sight (LOS) sensor value of a UWB tag having a line of sight from among the UWB tags.

IPC Classes  ?

• B60L 53/36 - Means for automatic or assisted adjustment of the relative position of charging devices and vehicles by positioning the vehicle
• H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
• H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
• B60L 53/12 - Inductive energy transfer
• H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
• G01C 22/00 - Measuring distance traversed on the ground by vehicles, persons, animals or other moving solid bodies, e.g. using odometers or using pedometers

Abstract

A cholangioscopy tube according to various embodiments of the present disclosure may comprise a tube body having a first tube end and a second tube end formed therein, wherein the tube body includes: an observation hole formed adjacent to the first tube end; and an endoscope insertion part formed adjacent to the second tube end.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/01 - Guiding arrangements therefor
• A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
• A61B 1/015 - Control of fluid supply or evacuation

Abstract

The present invention relates to a hybrid ring-type smart stethoscope and a method for manufacturing same. The hybrid ring-type smart stethoscope according to an embodiment of the present invention comprises: a connection part having a hollow hole into which a user's finger is inserted; an upper structure provided above the connection part; and a lower structure provided below the connection part and including a measurement module that, by being brought into contact with the user, collects body-related information that includes heartbeat or cardiopulmonary information of a user. The method for manufacturing the hybrid ring-type smart stethoscope according to an embodiment of the present invention, by comprising the steps of: preparing a connection part to be put on and worn by a user's finger; foldably installing an upper structure above the connection part; and foldably installing a lower structure below the connection part, has the advantage of being easy for a user to carry in everyday life while effectively auscultating the user's pulse wave and cardiopulmonary sound.

IPC Classes  ?

• A61B 7/04 - Electric stethoscopes
• A61B 7/00 - Instruments for auscultation
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/022 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention provides a system for measuring glucose and glycated hemoglobin, wherein: glucose is measured with separated plasma while separating plasma from blood through a red blood cell filter by allowing blood to flow through any one of a pair of channels; and hemoglobin or glycated hemoglobin produced by the destruction of red blood cells is measured by destroying the red blood cells collected in the red blood cell filter through plasma separation by allowing a buffer solution (lysis buffer) to flow through the other channel, thereby simultaneously measuring glucose, hemoglobin, and glycated hemoglobin using a small amount of blood.

IPC Classes  ?

• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
• G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance

Abstract

The present invention relates to a distributed storage method and apparatus for managing accessible information by using a blockchain-based enterprise network. In other words, the distributed storage method: establishes, by an enterprise network based on a multi-blockchain, an ERP system being operated within an enterprise; and, while restricting, according to a security level of the enterprise network, access rights to enterprise internal documents that have been processed by computational work, distributes and stores the enterprise internal documents in units of chucks in storage apparatuses for an enterprise connected by the enterprise network.

IPC Classes  ?

• G06F 21/78 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure storage of data
• G06F 16/182 - Distributed file systems
• H04L 9/40 - Network security protocols
• H04L 67/1097 - Protocols in which an application is distributed across nodes in the network for distributed storage of data in networks, e.g. transport arrangements for network file system [NFS], storage area networks [SAN] or network attached storage [NAS]
• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
• G06F 21/60 - Protecting data

Abstract

The present invention provides a method for manufacturing hollow PCM comprising the steps of: (a) forming polystyrene, which is a core material, by adding styrene, which is a precursor, and a thermal initiator to distilled water; (b) synthesizing core-shell structured hollow silica, by adding the polystyrene formed in step (a) to a mixed solution of distilled water and ethanol, adding cetyltrimethylammonium chloride (CTACl), which is a certain cationic surfactant, and TEOS, which is a silica precursor, and stirring for a set time, then adding an alkali material to the stirred solution, allowing to react at room temperature for a set time followed by filtering and a washing step, and then drying at a set temperature for a set time; and (c) synthesizing hybrid hollow silica, by inserting the hollow silica synthesized in step (b) to THF, adding an organic solvent in acidic conditions, refluxing for a set time, and then washing and drying.

IPC Classes  ?

• C01B 33/18 - Preparation of finely divided silica neither in sol nor in gel formAfter-treatment thereof
• C09K 5/02 - Materials undergoing a change of physical state when used

Abstract

According to the trocar for pediatric extraperitoneal hernia correction and a method for using same, which are proposed in the present invention, by comprising: a trocar housing made of a hollow shape for guiding a laparoscopic camera into an interior for pediatric extraperitoneal hernia correction; and an obturator that closes the end of the trocar housing and has a rounded end so as not to pierce the peritoneum during pediatric extraperitoneal hernia correction, the peritoneum may not be damaged by non-peritoneal surgery for complete epiperitoneal hernia correction in children, a space can be separated while a laparoscopic camera is put in place, and a field of view can be secured, thereby minimizing the inconvenience of pediatric surgery.

IPC Classes  ?

• A61B 17/34 - TrocarsPuncturing needles
• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials

Abstract

The present invention relates to a sandwich enzyme-linked immunosorbent assay (ELISA)-based leptin biosensor, and a method for detecting leptin by using same, and, more specifically, to a technique for electrochemically detecting leptin by using the oxidation reaction of o-phenylenediamine (oPD) on a screen-printed gold electrode (SPGE) on the basis of a sandwich ELISA [DTSSP/leptin Ab (capture antibody)/leptin/biotinylated leptin Ab (detection antibody)/streptavidin-HRP]. When the sandwich ELISA-based leptin biosensor of the present invention was used, a leptin concentration detection curve was identified to be in the range of 0.1-20 ng/mL, and stability, sensitivity, selectivity and effectiveness that are higher than those of commercial ELISA measurement were exhibited, and thus the biosensor is applied in clinics and point-of-care testing (POCT) so as to be applicable as a medical device capable of readily checking the criterion for obesity and obesity-mediated diseases.

IPC Classes  ?

• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones
• G01N 33/535 - Production of labelled immunochemicals with enzyme label
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a detection method of ransomware, a restoration method, and a computing device for performing the methods, wherein the detection method of ransomware, according to an embodiment of the present invention, may comprise the steps of: detecting an initial operation of a process for a file transmitted through a file system; when there is a possibility that the process may be determined as ransomware on the basis of the initial operation, setting a tracking mode for detecting whether the process is ransomware; after the initial operation is performed, determining whether at least one subsequent operation requested by the process for the file corresponds to an operation rule for determining ransomware; and when the at least one subsequent operation corresponds to the operation rule, determining the process as ransomware.

IPC Classes  ?

• G06F 21/56 - Computer malware detection or handling, e.g. anti-virus arrangements

Abstract

Provided is a remaining nutrient solution measuring device which receives the input of the type of a nutrient bag to be installed on a mounting part, measures a load acting on the mounting part, measures an inclination acting on the mounting part, corrects the load based on the inclination, calculates information on a remaining nutrient solution in the nutrient bag according to the load, and outputs information on the remaining nutrient solution.

IPC Classes  ?

• A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
• A61J 1/22 - Arrangements for transferring fluids, e.g. from vial to syringe with means for metering the amount of fluid
• A61J 1/10 - Bag-type containers
• A61J 1/16 - Holders for containers
• A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor

Abstract

Provided is a urine quantity measurement apparatus which: receives, as input, the type of a urine bag mounted on a mounting part; measures the load acting on the mounting part; measures the slope acting on the mounting part; corrects the load on the basis of the slope; calculates information about the quantity of urine inside the urine bag according to the load; and outputs the information about the quantity of urine.

IPC Classes  ?

• A61B 5/20 - Measuring urological functions
• A61F 5/451 - Genital receptacles
• A61F 5/44 - Devices worn by the patient for reception of urine, faeces, catamenial or other dischargeColostomy devices
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a biomarker for diagnosing pre-diabetes or predicting the onset of diabetic complications and use thereof and, more particularly, to: a composition and kit for diagnosing pre-diabetes or predicting the onset of diabetic complications, comprising an agent for measuring the expression level of any one or more selected from seven microRNAs; and a method for diagnosing pre-diabetes or predicting the onset of diabetic complications by using the marker. As a result of having analyzed microRNAs included in exosomes isolated from the blood of a normal group, a pre-diabetic patient group, and a diabetic patient group, the inventors of the present invention identified seven microRNAs specific to the pre-diabetic patient group. Therefore, the identified microRNAs can be used to diagnose pre-diabetes early, thus enabling the diagnosis of early diabetes, and are expected to be effectively used as biomarkers for predicting the onset of diabetes or diabetic complications.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

According to a photobiomodulation method and system for inducing the activity of a brain-derived nerve growth factor in a hippocampal tissue, proposed by the present invention, a photobiomodulation (PBMT or PBM) method, which is a therapy using infrared to seat-infrared (wavelength of 600-1100 nm) light, is utilized, thereby delaying the death of cells, promoting the proliferation of meristematic cells, and inducing natural treatment without the risk of adverse reactions to a disease or lesion, in a simple and easy manner in which low-level laser light is irradiated into a living body, based on the principle that certain molecules in the living body can absorb photons and trigger signaling pathways in response to light of a specific wavelength band.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light

Abstract

According to a non-contact image-based blood pressure measurement method and system based on advanced visual intelligence proposed in the present invention, a neural network is trained with an image sequence captured by a webcam in a non-contact manner to generate a blood pressure measurement model, and the blood pressure of a measurement subject is measured using the blood pressure measurement model. Therefore, since the webcam with which a moving image, that is, an image sequence, is captured in a non-contact manner is used, the blood pressure can be continuously estimated while capturing images with the webcam without contact with a device or another person. Moreover, since the blood pressure is estimated from a subject merely being in front of the webcam, the present invention is highly usable and inexpensive, and sufficient precision can be attained using a neural network algorithm.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

The present invention provides: a method for preparing a silicon/carbon nanofiber/graphene composite, comprising the steps of (a) mixing and dispersing predetermined silicon nanoparticles and CNFs in ethanol, and then ultrasonicating the mixture for a predetermined time, so as to synthesize an Si/CNF mixture, (b) adding a GO aqueous solution to the Si/CNF mixture having been prepared in step (a), and ultrasonicating and stirring the generated mixture for a predetermined time to synthesize an Si/CNF/GO dispersion, (c) filtering the Si/CNF/GO dispersion by vacuum filtration and drying same to synthesize an Si/CNF/GO composite, and (d) synthesizing an Si/CNF/rGO composite through heat treatment; and a method for manufacturing a secondary battery by using the composite.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/0569 - Liquid materials characterised by the solvents
• H01M 10/052 - Li-accumulators
• C01B 32/05 - Preparation or purification of carbon not covered by groups , , ,
• C01B 32/182 - Graphene
• C01B 33/02 - Silicon

Abstract

The present invention relates to a method for manufacturing a plastic-based radiation-shielding body, a radiation-shielding body thereof, and a radiation shielding apparatus using same. In the present invention, tungsten powder is mixed with plastic resin powder, the tungsten powder is subdivided and mixed stepwise at intervals of 10 to 30 minutes to form a mixture, the mixture is dispersed and extruded at an extrusion temperature of 200 to 220°C to prepare compounding pellets, and the compounding pellets are subjected to injection molding. Thus, by containing high-concentration and highly dispersed tungsten, the present invention provides excellent radiation-shielding efficiency, ensures linearity and rigidity, provides non-clumping properties, and enables manufacture in various shapes and sizes, and thus can be applied to a medical radiation device, or air precision transportation equipment.

IPC Classes  ?

• G21F 1/10 - Organic substancesDispersions in organic carriers
• G21F 5/00 - Transportable or portable shielded containers
• B29C 45/00 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor
• B29L 31/30 - Vehicles, e.g. ships or aircraft, or body parts thereof

Abstract

The present invention relates to a radiation shielding fabric, a method for manufacturing same, and a radiation shielding article using same. The radiation shielding fabric of the present invention is formed of yarn which is obtained by melt-spinning a PET base resin containing barium sulfate, and the fabric itself thus has shielding ability, thereby ensuring durability and reproducibility of shielding performance, and high strength and elasticity is realized so that the radiation shielding fabric can be applied to medical protective cloth for patients, radiation shielding clothing, etc.

IPC Classes  ?

• D03D 15/50 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads
• D03D 1/00 - Woven fabrics designed to make specified articles
• D01F 1/10 - Other agents for modifying properties
• D01D 5/08 - Melt-spinning methods
• A61B 6/10 - Safety means specially adapted therefor
• G21F 1/10 - Organic substancesDispersions in organic carriers
• G21F 3/02 - Clothing

Abstract

The present invention provides a pyrazolopyrimidine sulfonamide derivative represented by chemical formula 1, an isomer thereof, or a pharmaceutically acceptable salt thereof. As the pyrazolopyrimidine sulfonamide derivative of chemical formula 1 according to the present invention has an excellent Wee1 inhibitory activity effect, the derivative may inhibit growth and metastasis of a cancer cell by controlling a cell-division cycle and inhibiting a function of a cancer stem cell, and may be usefully utilized for the prophylaxis or treatment of a cancer-related disease which is a condition in which cancer cells exhibit abnormal proliferation. In addition, the pyrazolopyrimidine sulfonamide derivative according to the present invention may be usefully utilized for the prophylaxis or treatment of a cancer-related disease through combined use with chemotherapy using a chemical anticancer agent, an immune anticancer agent, a targeted therapeutic agent, and the like, or with radiation therapy. [chemical formula 1]

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a tungsten composite yarn with improved flexibility and shielding performance, a radiation-shielding fabric using same, and a radiation-shielding article. The tungsten composite yarn with improved flexibility and shielding performance of the present invention comprises: a tungsten wire; a first yarn primarily covering the outer circumferential surface of a core yarn while the tungsten wire is used as the core yarn; and a second yarn secondarily covering the outer circumferential surface of the first yarn, and thus provides excellent flexibility and durability, and the tungsten composite yarn can implement high shielding performance through a synergistic effect of two kinds of raw materials disclosed as radiation-shielding materials, and thus is applicable to radiation-shielding medical clothing, fire-fighting clothing, and the like.

IPC Classes  ?

• D02G 3/12 - Threads containing metallic filaments or strips
• D02G 3/38 - Threads in which fibres, filaments, or yarns are wound with other yarns or filaments
• D02G 3/36 - Cored or coated yarns or threads
• D02G 3/04 - Blended or other yarns or threads containing components made from different materials
• D02G 3/44 - Yarns or threads characterised by the purpose for which they are designed
• G21F 3/02 - Clothing
• A62B 17/00 - Protective clothing affording protection against heat or harmful chemical agents or for use at high altitudes

Abstract

The present invention relates to a device for monitoring the impact of nodes on an Ethereum network and a method for analyzing the impact of nodes on an Ethereum network, wherein the node impact analysis method involves ascertaining the relationship between a node and the performance of the Ethereum network, and determining the impact of a specific node on the Ethereum network by using the path along which a block generated in the node is propagated. Accordingly, the present invention can be used to evaluate the effect of nodes on the performance of the Ethereum network, and detect and prevent malicious security attacks, wherein the evaluation is centered on nodes having a large impact on network performance.

IPC Classes  ?

• H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
• H04L 12/26 - Monitoring arrangements; Testing arrangements

Abstract

According to a cord blood storage service system and method, using purchaser pre-matching, that register ownership information by using blockchain technology, presented in the present invention, biological data is used to match a potential purchaser of cord blood and a pregnant woman before delivery by the pregnant woman, so that storage of the cord blood is processed with money paid by the potential purchaser without payment by the pregnant woman, and thus the storage rate of cord blood, which is an important resource, is increased, cord blood is brokered so that patients requiring the cord blood can purchase the cord blood in a positive and legal method, and blockchain technology is used to issue ownership information of cord blood so that the issued ownership information is registered in the account of a potential purchaser, and thus the ownership information of the cord blood can be safely stored, read, and traded without the guarantee of a third party such as a cord blood bank.

IPC Classes  ?

• G06Q 30/08 - Auctions
• G06Q 30/06 - Buying, selling or leasing transactions
• H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
• H04L 29/06 - Communication control; Communication processing characterised by a protocol
• G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06Q 50/18 - Legal services
• G06Q 20/36 - Payment architectures, schemes or protocols characterised by the use of specific devices using electronic wallets or electronic money safes

Abstract

Proposed in the present invention is an apparatus and method for manufacturing a thin shielding film through an air pressurization-type tungsten powder filling processing technique using a curved reflection board, the apparatus comprising: a curved reflection board on which a film to be manufactured into the thin shielding film is positioned; a shielding material spray part which disperses tungsten nanopowder toward the front surface of the film positioned on the curved reflection board; and an adhesive resin spray part which disperses an adhesive resin in conjunction with the shielding material spray part in order to safely fix the film. The structure of the curved reflection board and the novel shielding material dispersion technique, in which particles of tungsten nanopowder dispersed while carried by air flow are uniformly dispersed, can ensure the reproducibility of the shielding process according to the processes of the manufacturing process.

IPC Classes  ?

• G21F 1/12 - Laminated shielding materials
• C23C 24/04 - Impact or kinetic deposition of particles
• B05C 5/02 - Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work from an outlet device in contact, or almost in contact, with the work
• B05C 13/02 - Means for manipulating or holding work, e.g. for separate articles for particular articles
• C08J 7/04 - Coating
• C08J 5/18 - Manufacture of films or sheets

Abstract

According to a radiation shielding pad made by compressing multiple layers of lattice-structured fiber manufactured using tungsten wires, and a manufacturing method therefor, which are presented in the present invention, tungsten fibers weaved using tungsten wires are overlapped in multiple layers so as to be stacked in a plurality of layers, and the tungsten fibers, which are overlapped in multiple layers so as to be stacked in a plurality of layers, are compressed to form one radiation shielding pad, and thus are woven into fibrous tissue so that shielding performance can be adjusted by means of the layers of fiber during low-dose radiation shielding, and ventilation is possible to enable wearing at all times in a low-dose radiation area.

IPC Classes  ?

• G21F 1/12 - Laminated shielding materials
• G21F 3/025 - Clothing completely surrounding the wearer
• A41D 31/04 - Materials specially adapted for outerwear characterised by special function or use

Abstract

The present invention relates to biopsy forceps. The biopsy forceps according to the present invention comprise: a tongs-assembly part having the form of tongs so as to be able to collect internal body tissue to be tested; a wire assembly part having the front end connected to the tongs-assembly part; a handle body part connected to the rear end of the wire assembly part so as to control the operation of the tongs-assembly part; and a balloon tube part having, at the front end, a balloon surrounding the tongs-assembly part. Thus, the biopsy forceps can stably collect internal body tissue.

IPC Classes  ?

• A61B 10/06 - Biopsy forceps
• A61B 10/04 - Endoscopic instruments, e.g. catheter-type instruments
• A61B 17/295 - Forceps for use in minimally invasive surgery combined with cutting implements
• A61B 17/29 - Forceps for use in minimally invasive surgery
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 5/283 - Invasive
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention relates to a micro RNA biomarker for predicting drug response to antidiabetics, and a use thereof. In the present invention, the drug response prediction markers miR-136-3p, miR-150-3p, miR-15a-3p, miR-337-3p, miR-369-3p, miR-376a-3p, miR-379-5p, miR-483-3p, miR-495-3p, and miR-6126 were selected by comparing miRNA profiles of a normal group and a diabetes patient group before and after administering an SGLT2 inhibitor that is an antidiabetic. It was confirmed that the expression patterns of the selected markers differed for the normal group and the diabetes patient group, and that the expression patterns for the diabetes patient group were restored so as to be similar to those for the normal group when the SGLT2 inhibitor that is an antidiabetic was administered to the diabetes patient group. Therefore, the marker according to the present invention may be useful as a marker for predicting drug response to antidiabetics.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

According to a device and a method for learning time series data on the basis of multilayer random forests, presented in the present invention, candidate regions detected in learning data composed of time series images of a plurality of consecutive frames are connected to create a tube, features are extracted from sub-tubes obtained by dividing the tube, and learning is performed by inputting the feature extracted from each sub-tube into each layer of a time series multilayer random forest classifier including a plurality of layers, thus fast computation speed is provided due to reduced learning parameters that should be maintained and a simple decision-making process, and far more flexible operation is possible than in RNN-based models.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

A novel benzoheterocycle compound or a pharmaceutically acceptable salt thereof showed a high anti-proliferative effect against cancer cell lines. Using this, a pharmaceutical composition for preventing or treating cancer disease can comprise the compound or a pharmaceutically acceptable salt thereof as an active ingredient. In addition, a health functional food composition for preventing or improving cancer disease can include the compound or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition or health functional food composition can effectively prevent or treat various cancer diseases.

IPC Classes  ?

• C07D 235/12 - Radicals substituted by oxygen atoms
• A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61P 35/00 - Antineoplastic agents
• C07D 263/57 - Aryl or substituted aryl radicals
• C07D 277/66 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2

Abstract

According to a delirium intervention mobile device and delirium intervention system for nursing home personnel proposed in the present invention, a mobile device running an application for nursing home personnel for delirium intervention targeting nursing home subjects is used to provide a predicted delirium risk according to risk factors, a delirium assessment result, and a checklist for delirium intervention, and thus, the nursing home personnel can easily and conveniently monitor delirium and intervene so as to prevent delirium using the application, thereby enabling nursing home personnel to preemptively exercise caution, or preemptive prevention of an onset of delirium, and effectively preventing the risk of a sudden onset of delirium.

IPC Classes  ?

• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services
• G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
• G06N 20/00 - Machine learning

Abstract

According to an energy-efficient pupil tracking method and device based on the simplification of a cascade regression forest proposed in the present invention, a lightweight cascade coarse-to-fine regression forest (CCD-RF) is generated by applying a rule distillation according to feature importance-based rule contribution to an initial CCD-RF which is composed of a cascade multilayer using a plurality of regression forests and has been trained on pupil position using a coarse-to-fine method, and the lightweight CCD-RF is used to predict pupil position from an image. Thus, the number of parameters and the amount of calculations can be reduced and energy consumption can be minimized while maintaining strong performance through the removal of unnecessary rules.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06K 9/48 - Extraction of features or characteristics of the image by coding the contour of the pattern
• G06N 20/00 - Machine learning

Abstract

According to a motor using asymmetric stator shoes and a manufacturing method therefor, present in the present invention, the motor comprises: a stator having a stator core in which a coil is wound around a cylindrical stator body; and a rotor, which is arranged inside the stator and rotates, has a shaft hole formed at the center thereof into which a rotary shaft can be pressed and inserted, and has a plurality of permanent magnets that are arranged on a rotor core and that are arranged in a radial shape from the rotating center so as to have a rotational radius, wherein the stator is formed so that the lengths of stator shoes, which are bent on both sides at the end of the stator core and extend, are imbalanced and different from each other, thereby reducing torque ripples and cogging torque that indispensably increase during design for increasing the power of rotational machinery, and thus the motor can be stably operated with minimized vibration and noise.

IPC Classes  ?

• H02K 1/14 - Stator cores with salient poles
• H02K 1/27 - Rotor cores with permanent magnets
• H02K 1/02 - Details of the magnetic circuit characterised by the magnetic material
• H02K 21/14 - Synchronous motors having permanent magnetsSynchronous generators having permanent magnets with stationary armatures and rotating magnets with magnets rotating within the armatures
• H02K 15/03 - Processes or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines of stator or rotor bodies having permanent magnets

Abstract

According to an electrocardiogram system and an electrocardiogram method proposed in the present invention, a long wire connected from a central unit to an electrode is eliminated and thus the problem of twisting or tangling of the wire can be resolved; and a small-sized mobile and portable wireless communicator is used and thus electrocardiogram can be simply and easily measured without needing to move a large and complex central unit.

IPC Classes  ?

• A61B 5/30 - Input circuits therefor
• A61B 5/282 - Holders for multiple electrodes
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
• A61B 90/92 - Identification means for patients or instruments, e.g. tags coded with colour

Abstract

According to a micro tungsten-based radiation shielding paper and a method for manufacturing same, provided by the present invention, a tungsten powder is molded in a particle dispersion manner into a shielding sheet; and the formed shielding sheet is thermally treated and then formed into a film type of highly densely charged paper through a cutting and molding process, whereby not only can a maximum radiation shielding effect be brought about without using lead harmful to the human body and the environment, but processing can also be freely and easily performed through a ultra-light and ultra-thin tungsten paper composed based on the sole material of tungsten.

IPC Classes  ?

• G21F 1/08 - MetalsAlloysCermets, i.e. sintered mixtures of ceramics and metals
• G21F 1/12 - Laminated shielding materials

Abstract

The present invention relates to a whitening composition comprising a plum seed extract as an active ingredient, and more specifically, provides a skin-whitening cosmetic composition, a health food composition, and a composition for preventing or treating skin conditions caused by overproduction of melanin, each of which comprises a plum seed extract as an active ingredient. The plum seed extract according to the present invention has more stable and superior tyrosinase inhibitory activity compared to the ascorbic acid conventionally used as a whitening material, and thus can be used as a functional cosmetic material for skin whitening and can effectively prevent or treat abnormal skin pigmentation disorders such as liver spots, freckles, and sunspots.

IPC Classes  ?

• A61K 8/9789 - Magnoliopsida [dicotyledons]
• A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A61K 36/736 - Prunus, e.g. plum, cherry, peach, apricot or almond
• A61P 17/00 - Drugs for dermatological disorders

Abstract

According to an automatic neck pillow dedicated to cervical spine rehabilitation exercise and a method of using same proposed in the present invention, the automatic neck pillow is configured to support a user's cervical spine through a cervical spine support formed in a central portion of a neck pillow body, and is configured to enable rolling massage of the user's cervical spine through a rolling device inserted and mounted inside wing extensions extending from both sides of the cervical spine support, such that it is possible to fix the cervical spine regardless of the shape of the cervical spine and the positions of the head and the shoulders in a posture of a normal positon of the body and a posture when lying on the side.

IPC Classes  ?

• A47G 9/10 - Pillows
• A61H 1/02 - Stretching or bending apparatus for exercising
• A61H 1/00 - Apparatus for passive exercisingVibrating apparatusChiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
• A61H 15/00 - Massage by means of rollers, balls, e.g. inflatable, chains, or roller chains

Abstract

According to an optical coherence tomography brain catheter for intracerebrovascular surgery and a method for using same, proposed in the present invention, the optical coherence tomography brain catheter comprises: a catheter distal portion including a distal non-braided OCT lens catheter for imaging an intracerebral vessel and a distal braided catheter integrally connected to the distal non-braided OCT lens catheter; a catheter proximal portion including a proximal braided catheter integrally connected to the distal braided catheter of the catheter distal portion and a proximal shaft integrally connected to the proximal braided catheter; and a microwire for guiding the direction in which the catheter distal portion inserted into a blood vessel travels along the blood vessel. Therefore, unlike the structure of the existing heart OCT catheter, the brain catheter can have improved exploration and propulsion for reaching a multifolded brain blood vessel and can minimize the interference of an optical coherence tomography for intracerebrovascular surgery.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61M 25/00 - CathetersHollow probes
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

The present invention relates to a biomarker for early diagnosis of diabetes or diabetic complications, and use thereof and, more specifically, to an ADAM2 biomarker for early diagnosis of diabetes or diabetic complications, a composition for early diagnosis of diabetes or diabetic complications using the biomarker, a diagnostic kit, and a method for providing information necessary for early diagnosis of diabetes or diabetic complications. The ADAM2 biomarker for early diagnosis of diabetes or diabetic complications of the present invention was confirmed to have a specifically reduced expression level in the pre-diabetes stage, compared to normal subjects, and a pattern was confirmed in which the expression thereof was further increased in diabetic retinopathy and diabetic nephropathy, which are diabetic complications, as compared to normal or diabetic subjects, and thus the biomarker can be useful for early diagnosis of diabetes or diabetic complications.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention relates to a novel Bacillus velezensis WK2019 strain and a milk fermentate using same. More specifically, the Bacillus sp. Bacillus velezensis WK2019, which is isolated from kimchi, was found to allow the provision of a milk fermentate that has a better flavor than those fermented with conventional Bacillus spp., and exhibits an increased GABA content and an anti-thrombotic effect. As such, the milk fermentate using the strain can be provided as a functional food.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A23C 9/12 - Fermented milk preparationsTreatment using microorganisms or enzymes
• C12R 1/07 - Bacillus

Abstract

22O for the hydrolysis of silane is mixed with a solvent; (b) adding, to the mixed solution prepared in step (a), a weakly basic substance as a catalyst for causing the polymerization reaction of silane; and (c) adding, to the mixed solution synthesized in step (b), [3-(methacryloyloxy)propyl]trimethoxysilane silane, which is a precursor of polysilsesquioxane.

IPC Classes  ?

• C08G 77/06 - Preparatory processes
• C08G 77/08 - Preparatory processes characterised by the catalysts used
• C08G 77/18 - Polysiloxanes containing silicon bound to oxygen-containing groups to alkoxy or aryloxy groups

Abstract

An electronic device according to various embodiments may comprise: a memory for storing instructions; and a processor connected to the memory. The processor may be configured to: acquire image data captured by using a camera; calculate a heart rate value by analyzing the image data; determine whether or not the heart rate value has been normally acquired; when the heart rate value has not been normally acquired, determine a correction value for a section in which the heart rate value has not been normally acquired; and store, in the memory, biometric data including the correction value.

IPC Classes  ?

• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• A63B 71/06 - Indicating or scoring devices for games or players

Abstract

According to a photobiomodulation method and system for inducing the activity of a brain-derived nerve growth factor in a hippocampal tissue, proposed by the present invention, a photobiomodulation (PBMT or PBM) method, which is a therapy using infrared to near-infrared (wavelength of 600-1100 nm) light, is utilized, thereby delaying the death of cells, promoting the proliferation of meristematic cells, and inducing natural treatment without the risk of adverse reactions to a disease or lesion, in a simple and easy manner in which low-level laser light is irradiated into a living body, based on the principle that certain molecules in the living body can absorb photons and trigger signaling pathways in response to light of a specific wavelength band.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis

Abstract

The present invention relates to a device for providing health state information using blood metabolism, and to a method therefor. According to the present invention, the device for providing health state information using blood metabolism comprises: a measurement unit which measures blood glucose and blood lactate values in a subject to be measured; a calculation unit which calculates a blood metabolism value by using the measured values; and a control unit which determines, by using the measured glucose value and the calculated metabolism value, a health state of the subject to be measured, and provides health state information corresponding to the determined result. According to the present invention, by calculating the blood metabolism value through measuring the amount of glucose and lactate in blood, and by providing health state information corresponding to the calculated result, the emergence of obesity and obesity-associated diseases, such as hyperlipidemia, can be diagnosed at an early stage.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value

Abstract

A method for predicting the likelihood of developing lung cancer by using an artificial intelligence model comprises the steps of: receiving, by means of an analysis device, a chest fluorodeoxyglucose (FDG) PET/CT image for a sample; inputting, by means of the analysis device, the F-18 FDG PET/CT image to a first classification neural network, and outputting prediction information related to development of lung cancer for the sample; and predicting, by means of the analysis device, a likelihood of developing lung cancer for the sample on the basis of the prediction information. The first classification neural network is trained by using chest F-18 FDG PET/CT images for healthy people and training images excluding lung cancer regions from chest F-18 FDG PET/CT images for lung cancer patients.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G06N 3/02 - Neural networks
• A61B 6/03 - Computed tomography [CT]
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

According to a system and method for a no-cost cord-blood banking service using buyer pre-matching, as proposed in the present invention, bio-data is used to match a pregnant woman with a potential cord blood buyer prior to giving birth, and by processing banking of cord blood with costs borne by the potential buyer and without any expenses from the side of the pregnant woman, the cost burden for banking cord blood on the side of the pregnant woman and family is reduced, thereby increasing the banking rate of cord blood which is an important resource, and acting as an intermediary such that cord blood may be purchased by a patient who needs cord blood through a positive and legal method.

IPC Classes  ?

• G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G06Q 30/08 - Auctions
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06Q 50/18 - Legal services

Abstract

Proposed in the present invention are a device for removing thrombi in varicose veins using a thrombus collecting mesh and a thrombus suction catheter, and a method for using same, the device comprising: a guide delivery tube which is provided with a guide wire that passes through lesions in the vein obstructed by thick thrombi, and ascends to a normal area of the vein to be mounted thereto; a sheath which is guided along the guide delivery tube and mounted to an appropriate blood vessel position for removing the thrombi in the vein; a thrombus collecting mesh which is mounted to the catheter inserted into the sheath, and passes through the thrombi and spreads out in the normal area of the blood vessel; and a suction catheter which is inserted into the sheath and suctions the thrombi collected in the thrombus collecting mesh. Accordingly, the thrombi in the vein obstructed by the thick thrombi can be easily removed without depending on the skill of a clinician.

IPC Classes  ?

• A61B 17/221 - Calculus gripping devices in the form of loops or baskets
• A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems

Abstract

According to a medical education system capable of observing the structure, function, and mutation of a blood vessel through an implantable biometric signal sensor, proposed in the present invention, it is possible to provide not only theoretical knowledge about a blood vessel, but also biometric information of the structure, function, and mutation of the blood vessel, and blood pressure and body temperature in real time, by using data received from the biometric signal sensor that can be implanted in a body, and it is possible to aid learning of human anatomy. By providing a user with an image of the state of the blood vessel in real time, it is possible to induce interest of the user and induce more active use of the medical education system.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/026 - Measuring blood flow
• A61B 5/01 - Measuring temperature of body parts
• G06Q 50/20 - Education
• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine

Abstract

According to a method and a device for detecting, in real time, a pupil position for a low specification environment system, presented in the present invention, pupil candidate areas for left and right eyes are estimated by applying fast radial symmetry transform (FRST) in an input eye image for fast pupil detection, the pupil candidate areas include an incorrect area due to noise such as reflected light or eyelashes in an image so that spatiotemporal similarity between left and right pupils is extracted in order to effectively exclude the incorrect area and estimate an optimal pupil position, and optimal left and right eye pupil positions are determined using the similarity, thereby excluding algorithms such as deep learning in order to achieve high speed processing, and using an optimized image processing algorithm so as to accurately detect positions of pupils for various pupil positions, changes in lighting brightness, partial blocking and a subject wearing glasses.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06K 9/46 - Extraction of features or characteristics of the image
• G06K 9/48 - Extraction of features or characteristics of the image by coding the contour of the pattern

Abstract

Presented in the present invention are a contactless PPG signal measurement system using a camera, and an operating method therefor, which use a feature in which the correlation between the strength of an optical signal in an image captured by the camera and subcutaneous reflectivity according to a change in a blood flow rate of a subject of whom the heart rate is to be measured, and thus can reduce a conventional inconvenience in which the subject of whom the heart rate is to be measured must wear a device for heart rate measurement during body contact, can very easily and simply measure the heart rate in an unrestrained state, and can measure the heart rate only while the subject of whom the heart rate is to be measured stands in the front of the camera for a moment, thereby reducing inconvenience in the use of a heart rate measurement system.

IPC Classes  ?

• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters

Abstract

According to a virtual hand illusion system for treatment of hemiplegia patients by using brain stimuli and an operation method therefor, proposed in the present invention, a head mounted display (HMD) device is used in combination with conventional mirror therapy to allow the user to enter a flow state in a virtual reality (VR) or augmented/mixed reality (MR) circumstance and to undergo rehabilitation in more comfortable postures, thereby maximizing the effect of misunderstanding the motion of a non-paralyzed limb as that of a paralyzed limb and throwing brain cognitive function into confusion to reduce pain that may be generated during rehabilitation. In this condition, the patient is subjected to rehabilitation while seeing only motion images on the display without looking his or her real paralyzed limb. In a flow state enhanced to the same degree, thus, the patient can receive rehabilitation therapy and ultimately the time taken for rehabilitation of hemiplegia patients can be reduced.

IPC Classes  ?

• A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• A61B 5/0476 - Electroencephalography
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

The present invention relates to peptides isolated from a protein hydrolysate of Tenebrio molitor mealworm and a composition comprising same as an active ingredient for prevention or treatment of liver injury. According to the present invention, a protein hydrolysate of Tenebrio molitor mealworm contains biologically active peptides having a size of 1 kDa or less, reduces the generation of reactive oxygen species, and increases the expression and activity of antioxidative enzymes, thereby effectively protecting hepatocytes from oxidative stress. Thus, the peptide can be advantageously used in a composition for prevention or treatment of liver injury, a health food composition for prevention or alleviation of liver injury, a health food composition for protection of the liver, an anti-oxidative health food composition, and so on.

IPC Classes  ?

• C07K 5/06 - Dipeptides
• C07K 5/062 - Dipeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A23L 33/18 - PeptidesProtein hydrolysates
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

According to a field-wound motor generator using a PM-ASSIST structure, proposed in the present invention, a field-wound motor generator having a stator and a rotor can be configured, wherein, as an improved structure in which a rotor coil and an auxiliary magnet are sequentially wound and arranged on the rotor is configured, the magnetic flux of a field magnet can be increased or demagnetized by means of transition of the direction in which power is applied to the rotor coil of the rotor comprising the auxiliary magnet, and the range of operational capacity can be secured accordingly.

IPC Classes  ?

• H02K 19/16 - Synchronous generators
• H02K 1/02 - Details of the magnetic circuit characterised by the magnetic material
• H02K 1/12 - Stationary parts of the magnetic circuit
• H02K 15/00 - Processes or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines
• H01F 1/053 - Alloys characterised by their composition containing rare earth metals
• H01F 1/057 - Alloys characterised by their composition containing rare earth metals and magnetic transition metals, e.g. SmCo5 and IIIa elements, e.g. Nd2Fe14B
• H01F 1/10 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites

Abstract

According to an IOT-based smart system for assisting infant bathing and a control method therefor proposed by the present invention, the system comprises: an infant bathing assisting device for measuring the temperature of bath water for bathing an infant, measuring the quality of the bath water, and measuring the movement of the infant; and a user device linked to the infant bathing assisting device to monitor a bathing state of the infant and a state of water in a bathtub. Through the configuration, a protector can monitor the bathing state of the infant and the state of water in the bathtub anywhere in a house in real time, and can confirm whether the infant is safe, while the infant has a fun and pleasant bath.

IPC Classes  ?

• G06Q 50/10 - Services
• G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services
• A47K 3/024 - Baths specially adapted for particular use, e.g. for washing the feet, for bathing in sitting position specially adapted for use for children or babies

Abstract

According to a system for monitoring a chronic heart failure state by using a chest tissue resistance value, and a method for using same proposed in the present invention, a chest tissue resistance measurement device including a resistance measurement unit, a signal processing unit, and a transmission unit is configured to be able to measure and monitor a chest tissue resistance value which decreases as a precursor to the reaching of the pulmonary capillary closing pressure and body fluid overload in a chronic heart failure patient. Thus, the state of disease in a chronic heart failure patient can be monitored in real time, and action can be taken according to the state.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

Abstract

The present invention relates to a calculus removal device comprising: an endoscope unit in which a camera is provided at the tip of an endoscope tube inserted along an internal organ or body cavity and captures images inside the internal organ or body cavity, and which outputs the captured images through a monitor; and a calculus removal unit which is inserted along the inside of the endoscope tube of the endoscope unit and selectively removes calculus. A scale ruler for estimating the size of the calculus using augmented reality is provided in a guide tube, basket, or crushing probe of the calculus removal unit, or on a screen of the monitor. Since the scale ruler can be used to estimate the size of the calculus through an endoscope prior to capturing the calculus, the time for a calculus removal procedure is reduced, and calculus removal is easy.

IPC Classes  ?

• A61B 17/221 - Calculus gripping devices in the form of loops or baskets
• A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 10/06 - Biopsy forceps
• A61B 10/04 - Endoscopic instruments, e.g. catheter-type instruments
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention provides a fermented jujube having an increased content of γ-aminobutyric acid (hereinafter referred to as GABA) by using complex fermentation and a preparation method therefor. More particularly, a method for preparation of fermented jujube having an increased content of GABA according to the present invention comprises the steps of: preparing a jujube extract; adding and mixing the jujube extract with fermentative sugars and a yeast extract; inoculating a first starter into the mixture to conduct primary fermentation; and adding monosodium glutamate (MSG) to the primarily fermented product and inoculating a second starter to the primarily fermented product to conduct secondary fermentation. The preparation method utilizes the complex fermentation of lactic acid bacteria and lactic acid bacteria, or yeast and lactic acid bacteria to effectively prepare fermented jujube having an increased content of GABA. The fermented jujube prepared according to the method has an increased content of GABA and as such, can be used in health functional foods or functional beverages.

IPC Classes  ?

• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

According to a system and method for topology investigation in a block-chain network proposed by the present invention, a topology analysis server receives data of a block-chain network and an active node, retrieved by an investigation client in the block-chain network, and updates an off-line topology model, so that it is possible to continuously investigate the topology of the block-chain network, and thereby evaluate the performance of the block-chain network and understand the robustness and security of the network.

IPC Classes  ?

• H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
• H04L 12/26 - Monitoring arrangements; Testing arrangements