Abstract

The present invention relates to a compound of formula (I) or (I'): A-X (I) A-L-B (I') wherein A and B are each independently a radical of the following formula (II) : The present invention also relates to the use of a compound of formula (I) or (I') as a colouring agent, in particular as a red colouring agent. The present invention also relates to a cosmetic, a pharmaceutical composition or a food product comprising at least one compound of formula (I) or (I').

IPC Classes  ?

• C09B 23/01 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain
• A23L 5/00 - Preparation or treatment of foods or foodstuffs, in generalFood or foodstuffs obtained therebyMaterials therefor
• C09B 23/10 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an even number of CH groups

Abstract

Compounds are used in the reactivation of butyrylcholinesterase. Such compounds are useful in the treatment or prevention of intoxication with at least one organophosphorus nerve agent. Pharmaceutical compositions and kits include the compounds, and compounds per se.

IPC Classes  ?

• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/695 - Silicon compounds
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine

Abstract

The present invention is in the field of the extraction of lithium from a material comprising lithium and at least another metal. In particular, the invention concerns a process of extraction of lithium at least, from a material comprising lithium and at least another metal.

IPC Classes  ?

• C22B 26/12 - Obtaining lithium
• C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions

Abstract

The invention relates to compounds of Formula I: The invention relates to compounds of Formula I: The invention relates to compounds of Formula I: or pharmaceutically acceptable solvates thereof, as well as their use in the treatment and/or prevention of diseases or conditions associated with a dysfunction of CFTR channel activity, in particular cystic fibrosis.

IPC Classes  ?

• C07D 237/14 - Oxygen atoms
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

Abstract

A tomographic atom probe includes an analysis chamber intended to analyze a sample of material in the form of a nanotip mounted on an anti-vibration support, the nanotip being brought to a temperature of between 0 kelvin and ambient temperature, the nanotip being biased at an adjustable voltage of between 1 kV and 15 kV, the analysis chamber comprising a position-sensitive and time of flight-sensitive ion detector. The atom probe comprises a generator for generating high-peak-intensity single-cycle ultrashort terahertz pulses, the analysis chamber comprising optical means for focusing the terahertz pulses, the focusing of the terahertz pulses causing the atoms of the nanotip to evaporate through the field effect without thermal effects. The terahertz pulses are generated by a femtosecond pulsed laser emitting very high-power ultrashort optical pulses at a high rate.

IPC Classes  ?

• H01J 37/285 - Emission microscopes, e.g. field-emission microscopes
• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support
• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes

Abstract

A method for imaging a material to atomic scale by means of a field-ion microscope having a vacuum chamber configured to accommodate the material prepared in the form of a tip and an imaging gas, and an ion detector is provided. The method includes application of a DC electrical potential (VDC) and of a pulsed electrical potential, of which the maximum pulse value is denoted Vimp, so that the tip erodes for a potential value equal to VDC+Vimp; acquisition, by the detector between at least two pulses of the pulsed potential, of series of at least two ion images of the impacts of the ions repelled by the tip onto the detector; and calculation of a quantity characteristic of a trend of the erosion of the tip based on the series of ion images acquired and the adjustment, between each series of images, of the values of VDC and of Vimp such that the quantity characteristic of the trend and the ratio VDC/Vimp remain constant.

IPC Classes  ?

• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes
• H01J 37/285 - Emission microscopes, e.g. field-emission microscopes

Abstract

The present invention relates to compounds for their use in the reactivation of butyrylcholinesterase. Such compounds are useful in the treatment or prevention of the intoxication with at least one organophosphorus nerve agent. The invention also relates to pharmaceutical compositions and kits comprising said compounds, and compounds per se.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/425 - Thiazoles
• A61K 31/433 - Thiadiazoles
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention relates to compounds for their use in the reactivation of butyrylcholinesterase. Such compounds are useful in the treatment or prevention of the intoxication with at least one organophosphorus nerve agent. The invention also relates to pharmaceutical compositions and kits comprising said compounds, and compounds per se.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention is in the field of the extraction of lithium from a material comprising lithium and at least another metal. In particular, the invention concerns a process of extraction of lithium at least, from a material comprising lithium and at least another metal.

IPC Classes  ?

• C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 26/12 - Obtaining lithium

Abstract

The present invention is in the field of the extraction of lithium from a material comprising lithium and at least another metal. In particular, the invention concerns a process of extraction of lithium at least, from a material comprising lithium and at least another metal.

IPC Classes  ?

• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 26/12 - Obtaining lithium
• C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions

Abstract

The invention relates to compounds of formula I (I) or pharmaceutically acceptable solvates thereof, as well as their use in the treatment and/or prevention of diseases or conditions associated with a dysfunction of CFTR channel activity, particularly cystic fibrosis.

IPC Classes  ?

• A61K 31/50 - PyridazinesHydrogenated pyridazines
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
• A61P 11/00 - Drugs for disorders of the respiratory system
• C07D 237/14 - Oxygen atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The invention relates to a tomographic atom probe comprising an analysis chamber (20) intended for analysing a sample (E) of material in the form of a nanotip mounted on an anti-vibration support (21), the nanotip being brought to a temperature between 0 Kelvin and room temperature, the nanotip being polarised at an adjustable voltage between 1 kV and 15 kV, the analysis chamber comprising an ion detector (27) sensitive to position and time of flight. The atom probe according to the invention comprises a generator (10) of ultrashort monocycle terahertz pulses with high peak intensity, the analysis chamber comprising optical means (26) for focusing said terahertz pulses, the focusing of the terahertz pulses leading to the evaporation of the atoms of the nanotip by field effect without thermal effects. The terahertz pulses are generated by a femtosecond pulsed laser emitting ultrashort optical pulses of very high power at a high rate.

IPC Classes  ?

• H01J 37/285 - Emission microscopes, e.g. field-emission microscopes
• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support

Abstract

DCimpDCimpDCimpDCimpimp remain constant.

IPC Classes  ?

• H01J 37/285 - Emission microscopes, e.g. field-emission microscopes
• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes

Abstract

The present invention concerns a novel method for synthesising diazirines, that may or may not be enriched in nitrogen-15, from amino acids or imines, via a one-pot synthesis method, comprising the reaction of the starting amino acid or imine with ammonia, which may or may not be enriched in nitrogen-15, and a hypervalent iodine oxidant. The present invention also relates to a method for synthesising ammonia enriched in nitrogen-15. The invention also concerns certain diazirines of formula (I) likely to be obtained by the claimed synthesis method, and also refers to the 1522-diazirines of formula (I'). The claimed diazirines can be used in photoaffinity labelling. The 1522-diazirines can also be used in hyperpolarisation, in particular in the medical imaging field.

IPC Classes  ?

• C07D 229/02 - Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms containing three-membered rings

Abstract

According to one aspect, the present description relates to a laser source for emitting a group of pulses, comprising: a primary laser source (22) that is suitable for emitting at least one primary laser pulse; at least one interferometer (24) that is suitable for forming, from said primary laser pulse, a plurality of secondary lases pulses, each interferometer comprising at least one delay line allowing two secondary laser pulses to be temporally separated by a delay comprised between 50 ps and 10 ns; and a single-mode amplifying optical fibre that is intended to receive the secondary laser pulses, in order to form, as output, a group of pulses that are spatially superposed.

IPC Classes  ?

• H01S 3/067 - Fibre lasers
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
• H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry

Abstract

The invention relates to a composition for composite material or composition of composite material, of polyaryletherketone (PAEK) type, said composition being characterised in that it comprises at least one reactive prepolymer, of formula X-(EKKE)-X and/or X-(PAEK)-X with a degree of polymerisation n such that 1 ≤ n ≤ 15 and preferably 2 ≤ n ≤10, where X represents two identical reactive terminal functional groups, each carrying a benzoyl group or a terminal phenoxy group, the functional groups X being capable of reacting together or with a chain extender by addition reactions.

IPC Classes  ?

• C08G 65/38 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols
• C08G 65/40 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols from phenols and other compounds
• C08L 71/00 - Compositions of polyethers obtained by reactions forming an ether link in the main chainCompositions of derivatives of such polymers

Abstract

The invention relates to fluorescent/fluorogenic probes of formula (I″) or (II″): 2′ being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and e being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity. It also relates to the use of these fluorescent/fluorogenic probes, for the detection of an enzyme activity, notably in order to identify/discriminate microorganisms in function of their ability to express particular enzyme activities.

IPC Classes  ?

• C07D 491/18 - Bridged systems
• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
• C09B 49/12 - Sulfur dyes from other compounds
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Abstract

This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

IPC Classes  ?

• C07D 253/07 - 1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61P 31/12 - Antivirals
• C07D 253/075 - Two hetero atoms, in positions 3 and 5

Abstract

This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 253/07 - 1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61P 31/12 - Antivirals

Abstract

This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

IPC Classes  ?

• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61P 31/12 - Antivirals
• C07D 253/07 - 1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention relates to a method of formulating a discriminator of objects which are obtained by an acquisition device furnished with a sensor, which comprises the following steps: - extraction of characteristics of n objects acquired, n > 1, the characteristics of an object constituting an observation xi which is associated with a class, i varying from 1 to n, the discriminator comprising Q classes with Q ≥ 2, - construction of a decision rule for deciding between the classes. This step of constructing the decision rule comprises the following substep: determining for each class q a discrimination function representing this class, q varying from 1 to Q, on the basis of parameters ce, positive or zero which are defined by calculating (I) with Mij = k(xi,xj)-λk(xi,xj) if xi, and xj belong to the same class or, Mij = -λk(xi,xj) otherise, k being a predetermined function with positive kernel, and λ a predetermined real nonzero regularizing parameter, and with for each class q, (II), lq being the set of indices of the observations of class q.

IPC Classes  ?

• G06K 9/62 - Methods or arrangements for recognition using electronic means

Abstract

The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): The invention also relates to novel epicocconone analogs.

IPC Classes  ?

• C07D 307/58 - One oxygen atom, e.g. butenolide
• C07D 311/76 - Benzo [c] pyrans
• C07D 493/04 - Ortho-condensed systems
• C09B 57/00 - Other synthetic dyes of known constitution
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A method for detecting respiratory cycle characteristics of a patient wearing a respiratory assistance mask comprises: - acquiring (20) sampled respiratory rate digital data at a predetermined acquisition frequency, thus defining a time-based rate curve; - defining (22) a size of a sliding time window for the rate; - predetermining (24) a pseudo-derivative by: for each sliding window, searching (26) for the maximum and minimum rates within the sliding window, and predetermining (28) the pseudo-derivative from the found maximum and minimum, the pseudo-derivative being defined as the difference between the found maximum and minimum, the pseudo-derivative being positive if the maximum appears after the minimum, and otherwise being negative; - moving (30) the sliding window toward the next rate sample; - detecting (32) a rate plateau when the pseudo-derivative is, as an absolute value, less than a predetermined value.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, a stereoisomer or a mixture in all proportions of stereoisomers thereof, in particular a mixture of enantiomers, such as a racemic mixture, wherein R represents a (C1-C6)alkyl or (C1-C6)alkenyl group, optionally substituted by one or more groups chosen among an halogen atom, ORa, SRb, NRcRd, PO(ORe)(ORf), CO2Rg, SO2Rh SO3R1, P0(0H)(CH(0H)Rk), CN, N3 and NH- C(=NH)NH2, with Ra, Rb, Rc and Rd, representing, independently of each other, an hydrogen atom, a (C1-C6)alkyl group or a -CO-(C1-C6)alkyl group, Re, Rf, Rg, Rh and R1 representing, independently of each other, an hydrogen atom or a (C1-C6)alkyl group, and Rk representing an aryl or heteroaryl group, said group being optionally substituted by one or more groups selected from an halogen atom and NO2, as well as to the use thereof and to a process for preparing such a compound, to a pharmaceutical composition containing it and to synthesis intermediates.

IPC Classes  ?

• C07C 229/48 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
• C07C 309/19 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings

Abstract

Compounds of formula (I) in which: R1 represents a hydrogen atom or a group of formula COR4, or else R1 represents a group of formula (A); R2 represents a group of formula NR5R6, or else R2 represents a nitrogen-containing heterocyclic, aryl or heteroaryl group; R3 represents a hydrogen atom or an alkyl group, m represents an integer between 1 and 6, n represents 0, 1 or 2, optical isomers thereof, and also the addition salts thereof with a pharmaceutically acceptable acid. Medicaments.

IPC Classes  ?

• C07C 323/61 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
• C07C 327/34 - Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
• C07D 205/04 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• C07D 211/34 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 213/55 - AcidsEsters
• C07D 213/73 - Unsubstituted amino or imino radicals
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors

Abstract

The invention relates to a gem-difluoro glycoconjugated compound having formula (I): wherein R is H or an alkyl, benzyl, acetyl, benzoyl group, each of R1 and R2, which are the same or different, is H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl, tertiobutyl- diphenylsilyl protective group or an acetal group of the CR'R' type, where each of R' and R', which are the same or different, is H or an alkyl, aryl, benzyl or thiophene group, R3 is H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, R4 is OR'', NGR'GR', N3, or a phthalimide, where R''' is H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tert-butyldiphenylsilyl protective group, each of GR' and GR', which are the same or different, is H or an alkyl, benzyl, benzoyl, acetyl, alkyloxycarbonyl, allyloxycarbonyl or benzyloxycarbonyl group, R5 is a free or protected hydroxyl group or a halogen, R6 is H or an alkyl, acetyl, benzyl, PO3H or PO3Na group. The invention is suitcable for preparing compounds that can be used particularly for the treatment of cancer.

IPC Classes  ?

• C07H 7/00 - Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
• A61K 31/70 - CarbohydratesSugarsDerivatives thereof

Abstract

The invention relates to a gem-difluoride C-glycopeptide compound with formula I where n is an integer equal to 3 or 4, R represents a hydrogen atom, an alkyl, benzyl, acetyl, trimethylsilyl, tert-butyldimethylsilyl, tert-butyldiphenylsilyl group, R´ represents OR, NR'R'', N3, or a phthalimide, R' and R'' represent a hydrogen atom or an alkyl, aryl, benzyl, benzoyl, acetyl, alkyloxycarbonyl, allyloxycarbonyl, benzyloxycarbonyl group, R1 represents a hydrogen atom or an alkyl, benzyl, alkylcarbamate, allylcarbamate, benzylcarbamate, acetyl group, R1 may consist of an amino acid if R2 represents only OR, R2 includes an amino acid if R1 represents a hydrogen atom or an alkyl, benzyl, alkylcarbamate, allylcarbamate, benzylcarbamate, acetyl group, R2 represents OR when R1 represents an amino acid, R3 represents a hydrogen atom or a free or protected alcohol function. It is applicable to the preparation of compounds or compositions to be used for preservation of biological materials such as cells, tissues and organs at various temperatures.

IPC Classes  ?

• C07D 309/10 - Oxygen atoms
• C07K 5/068 - Dipeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C07H 7/00 - Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
• A61Q 19/00 - Preparations for care of the skin
• A61Q 5/00 - Preparations for care of the hair
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds