A flexible circuit including a first segment including a base section of the flexible circuit; a second segment including a lateral wall section; a transition section between the base and lateral wall sections, the transition section being at least partially positioned adjacent a shared region of the base and lateral wall sections; and one or more electrode regions including a respective electrode, the one or more electrode regions being positioned at least partially in the transition section and the second segment.
A flexible substrate includes a number of layers, where each layer has a number of printed wires. The printed substrate is environmentally protected. The printed substrate is rolled and inserted into a catheter. Connectors are attached to each end of the rolled substrate. The connectors are connected to sensors at a distal end of the catheter and with electrical cards or a cable connector at a proximate end of the catheter. At least one layer of the substrate is connected to a coil in a magnetic sensor. A layer in which the traces are shorted in the distal end is used to measure a magnetic interference. These measurements are used by a processor or hardware to cancel out the magnetic interference effect on the other layers. Another printed substrate can be wrapped within the catheter shaft and used for non-magnetic type sensors.
A tool positioning system for use in a medical procedure includes a medical tool configured to be navigated to a target tool location within a portion of an organ of a patient. The medical tool includes a sheath having a tube defined by a sheath wall, the sheath extending a length in a proximal-distal direction and an inflatable balloon coupled to the sheath and configured to move along the length of the sheath in the proximal-distal direction. When the inflatable balloon is inflated at a target balloon location along the length of the sheath, the inflated balloon is fixed at the target balloon location. The tool positioning system also includes memory configured to store location of the tool in a three dimensional (3D) space and at least one processor configured to generate mapping information for displaying locations of the tool in the 3D space.
A61M 25/06 - Body-piercing guide needles or the like
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 17/00 - Surgical instruments, devices or methods
The invention relates to composition for skin care. In particular the invention relates to skincare composition comprising a myrrh resin extract, and a processed oat ingredient. The invention also relates to a method of treating the skin using said composition, and to a method for activating lipid production in the skin layers.
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
The invention relates to composition for skin care. In particular the invention relates to skincare composition comprising a myrrh resin extract, and a retinoid. The invention also relates to a method of treating the skin using said composition, and to a method for boosting the anti-aging effects of retinoids in the skin layers.
A surgical stapling assembly is disclosed. The assembly can include a cartridge body having cavities defined therein forming a pattern of openings in the deck of the cartridge body. The pattern can include longitudinally-repeating clusters of cavity ends. The assembly can also include fasteners removably positioned in the cavities. The pattern of openings can comprise openings on a first side of the cartridge body comprising inner openings each defining an inner proximal-to-distal axis oriented parallel to the longitudinal axis, outer openings each defining an outer proximal-to-distal axis obliquely-oriented relative to the longitudinal axis at an outer angle, and intermediate openings each defining an intermediate proximal-to-distal axis obliquely-oriented relative to the longitudinal axis at an intermediate angle, wherein the intermediate angle is different than the outer angle. The assembly can include a sled having offset ramps and/or an anvil comprising an arrangement of forming pockets proximal to the tissue stop.
A software for driving a motor in a powered surgical stapler can include a pausing monitoring process that may be effective to improve staple form and/or increase localized compression of tissue. The pausing monitoring process monitors firing speed of a firing bar driving by the motor and pauses the motor when the firing speed passes a speed error threshold. Before pausing the motor, the pausing monitoring process may also require that a pulse width modulated (PWM) electrical signal driving the motor has a duty cycle over a duty cycle threshold while the firing speed is beyond the speed error. The pausing monitoring process may force the firing bar through a predetermined distance immediately after pausing. The pausing monitoring process may be limited in the number of pauses that can be taken during a firing stroke.
A method of driving a motor in a powered surgical stapler can include a stall indication monitoring process that may be effective to improve staple form and/or increase localized compression of tissue. The stall indication monitoring process monitors firing speed of a firing bar driven by the motor and pauses the motor when the firing speed passes a speed error threshold. The stall indication monitoring process adjust a duty cycle of a PWM signal driving the motor to drive the firing bar to a target speed. The stall indication monitoring process can inhibit the duty cycle from increasing when force on the firing bar is above a force threshold limit. The pausing monitoring process may force the firing bar through a predetermined distance immediately after pausing. The pausing monitoring process may be limited in the number of pauses that can be taken during a firing stroke.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
The present application relates to improvements in lentiviral manufacturing for producing a CAR-T cell drug product, wherein the manufacturing method comprises changes to the time between host cell transfection and harvest, and new vector ratios for transfection. Presented herein are methods of preparing lentivirus with various vector ratios and times between host cell transfection and harvest, as well as transfection composition comprising the various vector ratios.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for the treatment and prevention of autoimmune diseases and disorders. Providing information in the field of treatment and prevention of autoimmune diseases and disorders.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Human pharmaceutical preparations for the prevention and
treatment of auto-immune and inflammatory diseases, central
nervous system diseases, dermatologic diseases, ophthalmic
diseases, hematological diseases, maternal fetal disorders. Medical information services, namely, providing information
to physicians, health care professionals, and patients on
the topic of prevention and treatment of auto-immune and
inflammatory diseases, central nervous system diseases,
dermatologic diseases, ophthalmic diseases, hematological
diseases, maternal fetal disorders.
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded or downloadable computer software for maximizing
efficiencies through temperature control for ablation during
cardiac ablation procedures sold as a component of cardiac
ablation apparatuses.
17.
METHODS FOR TREATING LEAKAGE FROM A GASTROINTESTINAL SITE
Disclosed herein are flowable biocompatible sealant compositions in the form of a biodegradable cross-linked gel, comprised of an insoluble agent for preventing infection, and an agent for preventing ischemia, wherein the agent for preventing ischemia is embedded in polymeric microparticles. The composition is characterized in that it releases at least part of said agents in a sustained manner. Uses of the compositions in methods for treating a leakage from a gastrointestinal site are further disclosed.
A catheter with a distal end assembly, an elongate flexible PCB (Printed Circuit Board) being housed within a shaft of the catheter, the elongate flexible PCB extending substantially along a full length of the shaft and including a PCB distal portion including a plurality of electrical connection pads, a PCB proximal portion including a plurality of conductive traces corresponding to the plurality of electric connection pads of the PCB distal portion, a PCB median portion including a plurality of conductive traces laid longitudinally along more than 75% of a length of the elongate flexible PCB, the conductive traces continuing the conductive traces of the PCB proximal portion and electrically connected to the plurality of electrical pads of the PCB distal portion, and a plurality of slits cutting through the PCB median portion between the conductive traces and extending along the conductive traces. Related apparatus and methods are also described.
Various exemplary devices, systems, and methods for multi-layer anti-stick coatings for surgical tools are provided. In general, a method of manufacturing a surgical tool includes forming, using plasma enhanced chemical vapor deposition with hexamethyldisiloxane as a precursor material, a first coating on a conductive tissue treating surface of the end effector and a second jaw component of the end effector, the first coating comprising a first material, wherein the first material is a first silicone material, and applying a second coating on top of the first coating on the first jaw component and the second jaw component, the second coating comprising a second material, wherein the coatings are effective to prevent tissue sticking to the jaws during an electrosurgical sealing procedure.
Compositions, kits and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof comprising alcaftadine or a pharmaceutically acceptable salt thereof.
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 9/00 - Medicinal preparations characterised by special physical form
TORIC CONTACT LENSES EMPLOYING STABILIZATION MECHANISM TO MINIMIZE EFFECT OF ASYMMETRIC EYELID BIAS IN SETTLED ORIENTATION, AND RELATED METHODS OF DESIGN
Toric contact lenses employing a stabilization mechanism to minimize the effect of asymmetric eyelid bias in settled orientation of the toric contact lens, and related methods of design. The toric contact lens includes stabilization zones that are each disposed horizontal sides of the lens periphery of the contact lens between its central optic zone and the lens edge. To minimize the effect of asymmetric bias of an eyelid of a patient wearer on the alignment of the toric contact lens to the principal meridians of the eye, the portion of the contour lines in the stabilization zones that are configured to intersect with an upper eyelid margin in wear are oriented to a target upper eyelid margin shape of a target upper eyelid of an average patient wearer. In this manner, the stabilization zone of the toric contact lens is more desensitized to any asymmetric shape of the wearer's eyelid.
A method for improving a reference set of soft toric contact lenses, an improved set of toric contact lenses and an improved toric lens are provided. The method involves identifying geometric characteristics of the reference lenses including at least a target sphere power, a radius of curvature of the posterior surface of the peripheral zone, a lens center thickness, a lens material refractive index, the optic zone diameter and an outer diameter of said transition zone; identifying a reference meridian of the reference set of toric lenses; reducing slope deviations along the reference meridian by adjusting a sag and the radius of curvature of the peripheral zone, and/or increasing the outer diameter of the transitional zone; and creating the improved set of lenses by applying the adjusted sag and radius of curvature, and/or increased outer diameter of the transition zone to all lenses within the improved set of lenses.
FITTING METHODS FOR ASTIGMATIC CONTACT LENS SETS INCLUDING APODIZED SINGLE- VISION LENSES FOR LOWER CYLINDER ERROR CORRECTION AND TORIC LENSES FOR HIGHER CYLINDER ERROR, AND RELATED ASTIGMATIC LENS SETS
Fitting methods for astigmatic contact lens sets that include apodized single vision lenses for lower cylinder error correction and toric lenses for higher cylinder error correction, and related astigmatic contact lens sets. An astigmatic eye with cylinder error greater than a higher designated cylinder error label power (e.g., > 1.25 diopter (D)) can be fitted with a non-apodization toric lens that has a stabilization mechanism. However, an astigmatic eye with a cylinder error up to the higher designated cylinder error label power (e.g., <= 1.25 diopter (D)) can be fitted with an apodized single-vision lens. The apodized single-vision lenses have an apodization profile that reduces aberrations to provide improved vision such that a larger number of astigmatic patients up to a higher cylinder error may find vision with an apodized single-vision lens acceptable, and with enhanced comfort that comes from not having a stabilization mechanism.
The invention relates to pharmaceutical compounds and pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as inhibitors of the SMARCA2 protein and to its use in the treatment of SMARCA4 deficient cancers, e.g., SMARCA4 deficient non-small cell lung cancer (NSCLC).
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Disclosed herein are flowable biocompatible sealant compositions in the form of a biodegradable cross-linked gel, comprised of an insoluble agent for preventing infection, and an agent for preventing ischemia, wherein the agent for preventing ischemia is embedded in polymeric microparticles. The composition is characterized in that it releases at least part of said agents in a sustained manner. Uses of the compositions in methods for treating a leakage from a gastrointestinal site are further disclosed.
Stereo visualization systems with objective lens assemblies for endoscopic visualization. A system include an endoscope tube and an optical assembly disposed within an interior cavity defined by the endoscope tube. The optical assembly includes a negative lens comprising a negative focal length, a positive lens group comprising at least one convex lens, and a beam folding prism that directs a beam of electromagnetic radiation on to a pixel array of an image sensor.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
28.
COMPOSITIONS AND METHODS FOR THE GENERATION OF ENGINEERED, AND OR ENGINEERABLE, CELLS
The present invention teaches compositions and methods for the generation of engineered and or engineerable cells, such as cells expressing a transmembrane polypeptide, for example a chimeric antigen receptor (CAR)-expressing cell, such as an immune cell, e.g., CD3+ immune cells, including gamma delta (γδ) T cells and the like.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Pharmaceutical preparations for the treatment and prevention of autoimmune diseases and disorders; (1) Providing information in the field of treatment and prevention of autoimmune diseases and disorders;
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for the treatment and prevention of autoimmune diseases and disorders. Providing information in the field of treatment and prevention of autoimmune diseases and disorders.
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded or downloadable computer software for maximizing
efficiencies through temperature control for ablation during
cardiac ablation procedures sold as a component of cardiac
ablation apparatuses.
33.
OPTICAL ASSEMBLIES FOR ENDOSCOPIC STEREO VISUALIZATION
Stereo visualization systems with objective lens assemblies for endoscopic visualization. A system include an endoscope tube and an optical assembly disposed within an interior cavity defined by the endoscope tube. The optical assembly includes a negative lens comprising a negative focal length, a positive lens group comprising at least one convex lens, and a beam folding prism that directs a beam of electromagnetic radiation on to a pixel array of an image sensor.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
Described herein are approved products and methods of using approved products for treating relapsed or refractory multiple myeloma in a patient. Also described herein are methods of selling or offering for sale an approved product.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
35.
METHODS OF TREATING CANCERS AND ENHANCING EFFICACY OF BCMAXCD3 BISPECIFIC ANTIBODIES
Disclosed are methods of treating cancers and enhancing efficacy of BCMAxCD3 bispecific antibodies. In particular, methods are disclosed of using a BCMAxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers, particularly relapsed or refractory multiple myeloma.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
An apparatus, system and method for a phacoemulsification handpiece. Included are: at least a first segment having a longitudinal axis, and a first end and a second end, wherein at least aspiration, irrigation and power inputs enter the first end; a second segment along the longitudinal axis and comprising, at a distalmost portion thereof from the first segment, a needle powered by the power input, an aspiration output, and an irrigation output; a rotating coupler capable of coupling the second end of the first segment and the second segment to enable independent axial rotation about the longitudinal axis of the first segment from the second segment; and a plurality of flexible tubing passing substantially along the longitudinal axis within both the first segment and the second segment. The plurality of flexible tubing flexes within the first and second segments and within the rotating coupler so as not to bind during the independent axial rotation.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61B 17/00 - Surgical instruments, devices or methods
Various exemplary devices, systems, and methods for anti-stick coatings for surgical tools are provided. In general, a method of manufacturing a surgical tool includes forming, using plasma enhanced chemical vapor deposition with hexamethyldisiloxane as a precursor material, a coating on a conductive tissue treating surface of an end effector, the coating comprising a silicone material, wherein the coatings are effective to prevent tissue sticking to the jaws during an electrosurgical procedure.
The present application discloses compounds having the following formula:
The present application discloses compounds having the following formula:
The present application discloses compounds having the following formula:
or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.
A modular catheter system includes a guiding sheath and multiple catheter inserts configured to couple to the guiding sheath. The guiding sheath can include a navigation sensor coupled to a distal portion of the guiding sheath shaft. A location of a distal portion of a respective catheter insert can be determined based on electrical signals from the navigation sensor. The catheter insert can be electrically coupled to the guiding sheath to provide electrical connection to an electrode assembly on the distal portion of the respective catheter insert. The guiding sheath may include a deflection mechanism that deflects the distal portion of the guiding sheath and a distal portion of a catheter shaft of the catheter insert. The modular catheter system may be configured to be tracked and moved without the catheter inserts requiring a navigation sensor or a deflection mechanism.
A method of electrically connecting a wire to a connection pad of a flexible circuit strip using a joining tool, which method comprising: receiving the flexible circuit strip on a support surface, wherein the flexible circuit strip includes a plurality of electrodes, a plurality of connection pads and conductive traces connecting each of the plurality of electrodes to a connection pad of the plurality of connection pads; positioning a joining tool over a first connection pad of the flexible circuit strip; monitoring a first capacitance between said joining tool and a conductive layer positioned under the connection pads, wherein said conductive layer is sized, shaped, and positioned to extend over a footprint of said plurality of connection pads; controllably lowering said joining tool toward said first connection pad until the first capacitance reaches a first predefined capacitance threshold, wherein said first predefined capacitance threshold defines a first height of said joining tool with respect to said flexible circuit strip; monitoring a second capacitance between a first electrode electrically connected to said first connection pad and said joining tool; controllably lowering said joining tool from said first height until said second capacitance reaches a second predefined capacitance threshold, wherein said second predefined capacitance threshold defines a second height of said joining tool with respect to said first connection pad; and activating said joining tool to electrically connect said first connection pad to said wire.
A catheter for mapping and ablation of epicardial tissue, including: a shaft configured for insertion into a body of a subject; a distal assembly configured at a distal end of the shaft, the distal assembly being expandable from a collapsed state to a deployed state; the distal assembly comprising at least two frame elements; each frame element comprising an arched distal portion on which a plurality of electrodes for delivery of ablation energy are disposed; wherein in the deployed state, the distal assembly assumes a concave profile for conforming to a curvature of the epicardium; and a plurality of position sensors disposed on one or both of the shaft and the frame elements for tracking a position and an orientation of at least a portion of the distal assembly or the shaft.
TORIC CONTACT LENSES EMPLOYING STABILIZATION MECHANISM TO MINIMIZE EFFECT OF ASYMMETRIC EYELID BIAS IN SETTLED ORIENTATION, AND RELATED METHODS OF DESIGN
Toric contact lenses employing a stabilization mechanism to minimize the effect of asymmetric eyelid bias in settled orientation of the toric contact lens, and related methods of design. The toric contact lens includes stabilization zones that are each disposed horizontal sides of the lens periphery of the contact lens between its central optic zone and the lens edge. To minimize the effect of asymmetric bias of an eyelid of a patient wearer on the alignment of the toric contact lens to the principal meridians of the eye, the portion of the contour lines in the stabilization zones that are configured to intersect with an upper eyelid margin in wear are oriented to a target upper eyelid margin shape of a target upper eyelid of an average patient wearer. In this manner, the stabilization zone of the toric contact lens is more desensitized to any asymmetric shape of the wearer's eyelid.
During surgery, debris being cleared from the target anatomy may inadvertently inhibit fluid communication between a suction instrument and a suction source. Therefore, it may be desirable to facilitate access to interior portions of the suction instrument and control of the amount of suction being provided through the suction instrument. The suction instrument can include an elongate cannula with a distal portion configured to be positioned within or adjacent to an anatomical passageway of a patient. The elongate cannula can define a suction lumen that can provide suction at the distal portion. A handle assembly can be associated with the elongate cannula and include a deformable grasping body defining a fluid communication chamber that can provide suction to the suction lumen. The deformable grasping body can elastically deform between relaxed and compressed states to alter the fluid communication between the fluid communication chamber and the suction lumen.
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61B 17/00 - Surgical instruments, devices or methods
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for the treatment and prevention of autoimmune diseases and disorders Providing information in the field of treatment and prevention of autoimmune diseases and disorders
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for the treatment and prevention of autoimmune diseases and disorders Providing information in the field of treatment and prevention of autoimmune diseases and disorders
46.
Sliding compression retainers for staple cartridges with implantable adjuncts
Retainers and retainer systems for staple cartridges with implantable adjuncts are disclosed. The retainers and retainer systems enable a compressive force to be applied to implantable adjuncts on staple cartridges.
MCNEIL CONSUMER PHARMACEUTICALS CO., MCNEIL CONSUMER PHARMACEUTICALS CO. is a Partnership organized under the laws of New Jersey. It is composed of MCNEIL-PPC, INC., A NEW JERSEY CORPORATION AND MCNEIL MMP, LLC, Limited liability company, New Jersey ()
The present disclosure is directed to temporary antimicrobial-eluting cement spacer implants, and assemblies, kits, and methods for forming the same. Particularly preferred disclosures are to modular spacers, assemblies, and kits, as well as methods of manufacturing the same, where the modular nature of the spacer permits the selection of specific desired length spacers, as well as specific selection of antimicrobial compounds and dosages, along with the components and processes for forming the same.
During surgery, debris being cleared from the target anatomy may inadvertently inhibit fluid communication between a suction instrument and a suction source. Therefore, it may be desirable to facilitate access to interior portions of the suction instrument and control of the amount of suction being provided through the suction instrument. The suction instrument can include an elongate cannula with a distal portion configured to be positioned within or adjacent to an anatomical passageway of a patient. The elongate cannula can define a suction lumen that can provide suction at the distal portion. A handle assembly can be associated with the elongate cannula and include a deformable grasping body defining a fluid communication chamber that can provide suction to the suction lumen. The deformable grasping body can elastically deform between relaxed and compressed states to alter the fluid communication between the fluid communication chamber and the suction lumen.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
The disclosed technology includes a connecting hub used with an end effector of a medical probe. The connecting hub is generally cylindrical in form and defines a hub lumen extending along a longitudinal axis between its terminal ends. Recesses are disposed about an outer circumferential surface of the cylindrical body and extend parallel to the longitudinal axis. Each recess is open along the longitudinal axis at or proximal the first terminal end and mates with a proximal end or a distal end of a spine of the end effector.
The disclosed technology includes monolithic framework for an end effector of a medical device. The monolithic framework includes cylindrical stock. The cylindrical stock includes a crown and multiple spines. The crown extends along a longitudinal axis, defines a crown lumen, and defines a plurality of crown recesses that, in use, connect to an annulus. The plurality of spines also extend along the longitudinal axis and bow outwardly relative to the longitudinal axis. Each spine extends from the crown to a spine terminal end and, in use, connects to a connecting hub.
A medical probe for insertion has at least one distal electrode coupled to an energy source to apply energy to tissue inside the body. A plurality of apertures are formed in the electrode. A fluid-directing assembly is disposed in the distal section of the probe having an axial channel that is in fluid communication with at least one trans-axial channel disposed at right angles to the axial channel and leading to an exterior of the assembly. A blocking terminus is disposed forward of the at least one trans-axial channel that prevents irrigation fluid from flowing axially in a forward direction so that the fluid flows outwardly into the lumen of the electrode in at least one trans-axial direction.
An electrophysiology catheter with a distal electrode assembly having covered spine carrying a plurality of microelectrodes. One or more spines have preformed configurations including at least a first portion with a first curvature and a second portion with a second curvature, and may include a linear portion. The linear portion may be between the first and second portions. The linear portion may be distal of the first and second portions. One or more spines have a narrower portion so that different portions of the spine can have different flexibility with a degree of independence in flexibility from adjacent portions.
A method of operating a medical device comprises electrically connecting a power device to the medical device. The method further comprises sensing at least one characteristic of one of the medical device with the power device. The method further comprises adjusting or maintaining one or more characteristics of an electrical connection feature the power device according to the at least one observed characteristic such that the electrical connection features of the power device and medical device are operationally compatible, and operating the power device according to an operational profile associated with the medical device.
A61B 17/072 - Surgical staplers for applying a row of staples in a single action, e.g. the staples being applied simultaneously
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/29 - Forceps for use in minimally invasive surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G01R 31/36 - Arrangements for testing, measuring or monitoring the electrical condition of accumulators or electric batteries, e.g. capacity or state of charge [SoC]
G01R 31/3828 - Arrangements for monitoring battery or accumulator variables, e.g. SoC using current integration
G01R 31/3842 - Arrangements for monitoring battery or accumulator variables, e.g. SoC combining voltage and current measurements
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
H01M 50/597 - Protection against reversal of polarity
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
57.
FITTING METHODS FOR ASTIGMATIC CONTACT LENS SETS INCLUDING APODIZED SINGLE VISION LENSES FOR LOWER CYLINDER ERROR CORRECTION AND TORIC LENSES FOR HIGHER CYLINDER ERROR, AND RELATED ASTIGMATIC LENS SETS
Fitting methods for astigmatic contact lens sets that include apodized single vision lenses for lower cylinder error correction and toric lenses for higher cylinder error correction, and related astigmatic contact lens sets. An astigmatic eye with cylinder error greater than a higher designated cylinder error label power (e.g., >1.25 diopter (D)) can be fitted with a non-apodization toric lens that has a stabilization mechanism. However, an astigmatic eye with a cylinder error up to the higher designated cylinder error label power (e.g., <=1.25 diopter (D)) can be fitted with an apodized single-vision lens. The apodized single-vision lenses have an apodization profile that reduces aberrations to provide improved vision such that a larger number of astigmatic patients up to a higher cylinder error may find vision with an apodized single-vision lens acceptable, and with enhanced comfort that comes from not having a stabilization mechanism.
The following disclosure is directed to systems, methods, and devices for lowering the hurdle associated with the cost of ophthalmology examinations. An information processing system is disclosed, comprising a user terminal and a server capable of communicating with the user terminal, wherein the server includes: an extracting unit for extracting at least one user who satisfies a predetermined condition based on eye-related behavior history of a user received from the user terminal; and an outputting unit for outputting information necessary for the extracted user to receive medical insurance that covers a part or all of ophthalmology examination costs and transmitting the information to the user terminal of the user.
Position data is captured for a first plurality of registration points along an anterior region of a head of a patient, based on a signal from a position sensor of a registration probe as the registration probe is positioned at each registration point of the first plurality of registration points. Each of the signals from the position sensor indicating a corresponding real-time position of the position sensor in three-dimensional space. Position data is captured for a second plurality of registration points along a lateral region of a head of a patient, based on a signal from a position sensor of a registration probe as the registration probe is positioned at each registration point of the second plurality of registration points. A real-time position of the patient is registered with an image guided surgery system, based on at least the captured position data for the first and second captured registration points.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
60.
Optimized Posterior Surface for Toric Contact Lenses
A method for improving a reference set of soft toric contact lenses, an improved set of toric contact lenses and an improved toric lens are provided. The method involves identifying geometric characteristics of the reference lenses including at least a target sphere power, a radius of curvature of the posterior surface of the peripheral zone, a lens center thickness, a lens material refractive index, the optic zone diameter and an outer diameter of said transition zone; identifying a reference meridian of the reference set of toric lenses; reducing slope deviations along the reference meridian by adjusting a sag and the radius of curvature of the peripheral zone, and/or increasing the outer diameter of the transitional zone; and creating the improved set of lenses by applying the adjusted sag and radius of curvature, and/or increased outer diameter of the transition zone to all lenses within the improved set of lenses.
Provided herein are immunoconjugates, such as radioimmunoconjugates, comprising a therapeutic moiety conjugated to an antibody or antigen binding domain with binding specificity for hK2. In certain embodiments, the hK2-specific immunoconjugate demonstrates a short half-life. Also provided herein are methods of using the immunoconjugates for selectively targeting cancer cells and for treating diseases such as prostate cancer.
A method of operating a surgical assembly is disclosed. The method includes receiving a first input from a first RFID scanner indicative of a first information stored in a first RFID chip of a first modular component of the surgical assembly, receiving a second input from a second RFID scanner indicative of a second information stored in a second RFID chip of a second modular component of the surgical assembly, determining an operational parameter of a motor of the surgical assembly based on the first input and the second input, and causing the motor to effect a tissue treatment motion of the first modular component.
A61B 17/115 - Staplers for performing anastomosis, e.g. in a single operation
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/072 - Surgical staplers for applying a row of staples in a single action, e.g. the staples being applied simultaneously
A61B 90/96 - Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text using barcodes
A61B 90/98 - Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders
G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
G06K 19/077 - Constructional details, e.g. mounting of circuits in the carrier
63.
MULTISPECIFIC BINDING MOLECULES COMPRISING LTBR AND EDB BINDING DOMAINS AND USES THEREOF
Provided herein are anti-LTBR multispecific binding molecules, nucleic acids encoding the anti-LTBR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTBR multispecific binding molecules. Also provided are methods of treating cancer in a subject in need thereof, the methods comprising administering the pharmaceutical compositions disclosed herein.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
64.
FILTER FOR MONOPOLAR SURGICAL INSTRUMENT ENERGY PATH
An electrosurgical system includes an instrument, an RF energy generator, and two ground pads. The instrument includes an electrode and a conductive shield that is configured to collect a capacitive coupling current that is induced by the application of RF energy to tissue by the electrode. A first electrical lead couples the first ground pad with the ground return of the conductive shield and the generator. The ground return is configured to divert a first portion of the capacitive coupling current to the generator via the first electrical lead. A second electrical lead couples the second ground pad with the ground return of the conductive shield and the generator. The ground return is configured to divert a second portion of the capacitive coupling current to the generator via the second electrical lead. The first and second portions of the capacitive coupling current are substantially equal.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 18/16 - Indifferent or passive electrodes for grounding
65.
SUPPLYING ELECTRICAL ENERGY TO ELECTROSURGICAL INSTRUMENTS
An end effector for a surgical tool includes a distal clevis, first and second jaws rotatably mounted to the distal clevis at a first axle, a proximal clevis rotatably coupled to the distal clevis at a second axle, and an electrical conductor extending through and electrically bypassing the proximal clevis and terminating at the distal clevis to supply electrical energy to at least one of the first and second jaws via conduction. A portion of the electrical conductor provides a conductive spring member that allows the electrical conductor to flex as the distal clevis articulates.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/29 - Forceps for use in minimally invasive surgery
A surgical tool includes a drive housing removably coupled to a tool driver of a robotic surgical system, a shaft extending from the drive housing, an end effector arranged at an end of the shaft, and a computer system. The computer system is programmed to send a command signal to a motor of the tool driver to drive rotation of a drive shaft mounted within the drive housing, monitor torque and rotational motion of the motor with a torque sensor and a rotary encoder, respectively, in communication with the computer system, measure an unexpected change in the torque or the rotational motion of the motor with the torque sensor or the rotary encoder when the surgical tool is manually bailed out by manually rotating the drive shaft and backdriving the motor, report the unexpected change as a bailout signal, and disable the surgical tool once the bailout signal is received.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
67.
TECHNIQUES FOR ADAPTIVE CONTROL OF MOTOR VELOCITY OF A SURGICAL STAPLING AND CUTTING INSTRUMENT
A surgical stapler is presented having a firing assembly, a motor, and a motor control circuit. The firing assembly is configured to translate along a longitudinal axis such that translation of the firing assembly in a distal direction is configured to deploy staples from an end effector during a firing stroke. The motor assembly includes a motor configured to drive the firing assembly along the longitudinal axis. The motor control circuit is configured to receive a firing signal indicating initiation of the firing stroke, drive the motor with a motor drive signal comprising a pulse width modulated (PWM) signal having a first constant duty cycle such that the firing assembly is translated through an initial distance, and increase a duty cycle of the PWM signal based at least in part on movement of the firing assembly through the initial distance.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/072 - Surgical staplers for applying a row of staples in a single action, e.g. the staples being applied simultaneously
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61B 17/16 - Instruments for performing osteoclasisDrills or chisels for bonesTrepans
A61B 17/29 - Forceps for use in minimally invasive surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
The disclosed technology includes irrigation manifold that routes irrigation fluid to an end effector for a medical device. The irrigation manifold includes a housing and a diverter that extend along a longitudinal axis and respectively connect with irrigation tubes. The end effector includes jackets that each define an irrigation conduit connecting with the irrigation manifold to allow an even distribution of irrigation fluid flow through the jackets.
A system includes a medical probe and a processor. The medical probe includes a shaft for insertion into a cavity of an organ of a patient; an expandable assembly fitted at a distal end of the shaft, wherein the expandable assembly has elastic properties; a position sensing element mounted on the distal end of the shaft; and at least one distal position sensing element on a distal end of the expandable assembly. The processor senses relative location of each of the at least one distal position sensing element and the proximal position sensing element; determines deflection of the expandable assembly based on the relative location; relates the deflection to the contact force applied on the expandable assembly; and provides an indication of the contact force on a display.
The present disclosure relates to methods of administering a cyclic peptide inhibitor of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding compositions, assays, methods, and/or uses for treatment of ulcerative colitis.
A61K 31/4433 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
An apparatus includes a first body, a position sensor, and a screw. The first body defines a bore having a first length. The position sensor is fixed relative to the first body. The position sensor is configured to generate a signal indicating a real-time position of the position sensor within three-dimensional space. The screw is sized to fit in the bore and secure the first body to bone of a patient. The screw has a second length. The first length is greater than the second length.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
72.
MEDICAL INSTRUMENT WITH TRANSLATING ACTUATOR TO STEER SHAFT
Catheter shafts (such as guide catheter or dilation catheter shafts) disclosed herein can include a rigid proximal portion, a deflectable distal portion located distally from the proximal portion, and a pull wire extending from the deflectable distal portion along the proximal portion. The pull wire can drive the deflectable distal portion between a straight configuration and a bent configuration, which makes the catheter system adaptable for use with both pediatric and adult patients. Specifically, because the pull wire facilitates changing a bend angle of the deflectable distal portion of the catheter shaft, the catheter can fit in a wide variety of differently sized nasal cavities and Eustachian Tubes. Optionally, a visualizing distal tip can be positioned distally from the deflectable distal portion of the catheter shaft and include a distally facing camera that can be used to confirm that the deflectable distal portion is properly positioned in the patient.
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/233 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the nose, i.e. nasoscopes
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
73.
METHODS AND MATERIALS FOR SCALABLE 3D CELLULAR REDIFFERENTIATION
Methods and materials for the cellular redifferentiation of induced pluripotent stem cell (iPSC)-derived hematopoietic stem cells (iHSCs) comprising a scalable, 3D method using a vertical-wheel bioreactor.
Provided herein are accessories for drug injection devices and methods of injecting a drug using the drug injection devices and the attached accessory. The accessory may comprise a first engagement surface that can engage the needle guard of the drug injection device and a second engagement surface that can engage a lower housing of the drug injection device. The needle guard of the drug injection device may be configured to transition between an extended position in which the needle guard shields a needle of the drug injection device and a retracted position in which the needle guard retracts relative to the lower housing to reveal the needle. When engaged with the corresponding portions of the drug injection device, the accessories described herein can prevent the needle guard of the drug injection device from transitioning from the retracted position to the extended position prior to completing the injection.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
Staple cartridge systems with implantable adjuncts and retainers are disclosed. The staple cartridge systems ensure the full-cutting of the implantable adjuncts through the structure/manufacturing of the implantable adjuncts and the retainers.
Retainers and retainer systems for staple cartridges with implantable adjuncts are disclosed. The retainers and retainer systems enable a compressive force to be applied to implantable adjuncts on staple cartridges. The retainer is movable through a range of motion relative to the staple cartridge, and movement of a retainer cam through a track compresses the implantable adjunct against the deck of the elongate body.
Modified oligonucleotides comprising modifications at the 2′ and/or 3′ positions(s) along with methods of making and use, e.g., against HBV are disclosed.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
An apparatus includes a first body, a position sensor, and a screw. The first body defines a bore having a first length. The position sensor is fixed relative to the first body. The position sensor is configured to generate a signal indicating a real-time position of the position sensor within three-dimensional space. The screw is sized to fit in the bore and secure the first body to bone of a patient. The screw has a second length. The first length is greater than the second length.
Navigation sensors can indicate a real-time location of a surgical instrument within a patient. An adapter or other component that can be readily coupled with a surgical instrument and has one or more integral navigation sensors. The adapter can include an adapter body, an instrument coupling arm, and one or more navigation sensors. The adapter body extends between a proximal end and a distal end of the adapter. The instrument coupling arm is configured to non-removably engage a portion of the instrument. The one or more navigation sensors are configured generate signals indicating a position of at least a portion of the instrument in three-dimensional space and can be arranged in various configurations about the adapter body.
Devices, methods and systems are provided for occluding a left atrial appendage. In one embodiment, a medical device includes a cover portion and a foam anchor portion with a flexible member coupled therebetween. The cover portion is configured to be positioned over an ostium of the left atrial appendage. The foam anchor portion extends between a proximal end and a distal end to define a length and an axis defined along the length of the foam anchor portion. The foam anchor portion defines a curved external surface radially extending relative to the axis such that the curved external surface extends between the proximal and distal ends of the foam anchor portion. The foam anchor portion is configured to self-expand to provide an outward biasing force from the curved external surface such that a circumferential surface area of the curved external surface biases against tissue of the left atrial appendage.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
90.
REINFORCEMENT AND STRESS RELIEF FOR AN IRRIGATED ELECTROPHYSIOLOGY BALLOON CATHETER WITH FLEXIBLE-CIRCUIT ELECTRODES
A catheter balloon includes a membrane having a proximal end and a distal end. A plurality of substrates are bonded about the membrane. The ability of a bond's ability to withstand repeated stresses during use may be improved by using a reinforcement or a stress relief, while also minimizing the overall thickness of the balloon proximate to its distal end. The reinforcement may comprise a portion of an unassembled membrane. Alternatively, the reinforcement may comprise an adhesive-margin tip. The stress relief may be a serpentine portion of a distal tail of a substrate.
A catheter adapted or high density mapping and/or ablation of tissue surface has a distal electrode array with offset spine loops, each spine loop having at least a pair of linear portions and a distal portion connecting the pair of linear portions, and one or more electrodes on each linear portion. The linear portions of the plurality of offset spine loops are arranged in-plane a single common plane, and the distal portions of the plurality of offset spine loops are arranged off-plane from the single common plane.
A methods and systems are disclosed to determine positions of one or more distal end portions of a catheter. In embodiments, the method includes processing location signals that are transmitted by a transmitter-receiver utility having a first clock, and received by a position sensor at a catheter's distal-end portion. The processing may be performed by a signal processor having a second clock not synchronized with the first clock of the transmitter-receiver utility. The processing includes: determining a clock-rate-ratio between clock-rates of the first and second clocks; determining a time-lag between the first and second clocks; and determining the relative phases of the received signals while compensating for the clock-rate-ratio and for the time-lag between the clocks, such that determined phases are adjusted relative to the first signal clock of the transmitter receiver utility. Accordingly, the position of the catheter's distal-end portion can be determined based on the relative phases.
Various surgical systems configured to analyze surgical procedure trends are disclosed. The surgical systems can further be configured to provide recommendations and/or adjust control algorithms executed by the surgical systems according to the identified trends. The identified trends can be utilized to determine a baseline or recommended action to be performed at a decision point in a surgical procedure. The surgical systems can be configured to provide preoperative, intraoperative, or postoperative feedback to users based on their decisions at the decision points relative to the determined baseline or recommended actions.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A generator, ultrasonic device, and method for controlling a temperature of an ultrasonic blade are disclosed. A control circuit coupled to a memory determines an actual resonant frequency of an ultrasonic electromechanical system comprising an ultrasonic transducer coupled to an ultrasonic blade by an ultrasonic waveguide. The actual resonant frequency is correlated to an actual temperature of the ultrasonic blade. The control circuit retrieves from the memory a reference resonant frequency of the ultrasonic electromechanical system. The reference resonant frequency is correlated to a reference temperature of the ultrasonic blade. The control circuit then infers the temperature of the ultrasonic blade based on the difference between the actual resonant frequency and the reference resonant frequency. The control circuit controls the temperature of the ultrasonic blade based on the inferred temperature
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/3211 - Surgical scalpels or knivesAccessories therefor
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Navigation sensors can indicate a real-time location of a surgical instrument within a patient. An adapter or other component that can be readily coupled with a surgical instrument and has one or more integral navigation sensors. The adapter can include an adapter body, an instrument coupling arm, and one or more navigation sensors. The adapter body extends between a proximal end and a distal end of the adapter. The instrument coupling arm is configured to non-removably engage a portion of the instrument. The one or more navigation sensors are configured generate signals indicating a position of at least a portion of the instrument in three-dimensional space and can be arranged in various configurations about the adapter body.
An ocular access instrument (20) includes an attachment assembly (32) configured to engage the sclera of an eye, and an actuator assembly (34) configured to bear against the sclera. When the attachment assembly engages the sclera, movement of the actuator assembly inward against the eye displaces the choroid from the sclera, thereby creating an enlarged suprachoroidal space. The ocular access instrument can further include a needle guide (40) that is configured to receive a needle and guide the needle into the enlarged suprachoroidal space.
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
99.
Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody
A method of treating Crohn's disease in a patient administers an IL-23 specific antibody, e.g., guselkumab, at an initial intravenous dose and subsequence subcutaneous doses.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
100.
OVERCOMING DATA MISSINGNESS FOR IMPROVING PREDICTIONS
Disclosed herein are methods for training and deploying a predictive model for generating a prediction, e.g., patient eligibility for a CAR-T therapy. Datasets, such as open healthcare claims datasets, may be missing data. Missing data may hamper the ability to generate sufficient information needed for training a predictive model. Methods include leveraging comprehensive datasets, such as closed claims datasets, to create training examples for input into a machine learning algorithm. In various embodiments, the comprehensive dataset is modified to simulate the data missingness in the target dataset; then, the modified dataset is paired with the ground truth label derived from the comprehensive dataset to create training examples. In various embodiments, a comprehensive dataset is paired with a target dataset to create training examples. After training a predictive model on such examples, the model can be deployed to make predictions in the target dataset even in light of missing data.
