Systems and subsystems for cutting and stapling tissue are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument is a robotic attachment including a roll subsystem. The roll subsystem comprises a rotatable shaft having a longitudinal axis, a roll input puck engageable with a roll robotic output, a worm gear coupled to and rotatable by the roll input puck, and a worm follower coupled to the rotatable shaft. Rotation of the roll input puck causes the worm gear to rotate the worm follower and thereby roll the rotatable shaft about its longitudinal axis.
A surgical instrument includes a body, a shaft assembly, an ultrasonic blade, and a clamp arm assembly. The shaft assembly extends distally from the body and includes an outer sheath and a first pivot portion such that the outer sheath and the first pivot portion are integrally formed together with each other as a first unitary piece. The clamp arm assembly includes a clamp arm and a second pivot portion such that the clamp arm and the second pivot portion are integrally formed together with each other as a second unitary piece. The clamp arm assembly is pivotally coupled to the shaft assembly via the first and second pivot portions.
A surgical device having at least one rotary input screw in the end effector is provided. A rotary input screw can extend through a central longitudinal portion of the end effector. The end effector can include an improved closure system, firing systems, leveraging and alignment features between the staple cartridge and the surgical device, staple cartridges having multi-staple drivers, single-firing knifes and lockout/safety features for the same, and/or modified staple patterns, for example. Certain components can be 3D-printed components.
An apparatus includes a conductive cable, a pulley assembly, and an end effector electrically coupled to the conductive cable. The pulley assembly includes an inner body defining a cable pathway, an outer body fixed to the inner body, and a distal cap defining an interior. The end effector includes a distal hook that can deliver therapeutic energy to tissue, and a proximal body fixed relative to the dismal hook. The proximal body defines a conductive wire channel in communication with the cable pathway defined by the inner body. The conductive cable extends though the cable pathway of the inner body and into the conductive wire channel. The proximal body of the end effector defines a first port located within the interior of the distal cap, where the first port extends from an outer surface of the proximal body into the conductive wire channel.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p.ex. des courants à haute fréquence
A surgical instrument includes an end effector located at a distal end of a shaft and is selectively movable between an open configuration and a closed configuration. The end effector includes a guide with an ultrasonic blade extending therefrom and a clamp arm having a clamp pad and movable relative to the ultrasonic blade. The end effector further includes a tissue stop encircling the guide and having a leading surface. The tissue stop is configured to prevent tissue from moving proximally past the clamp pad during a closure stroke. In some versions, a leading surface of the tissue stop prevents tissue from moving proximally. The tissue stop may include a pair of deflectable flaps having the leading surface, wherein the deflectable flaps abut the clamp arm or other features of the end effector as the closure stroke is performed.
An end effector for a surgical tool includes a jaw including a shank and a contact plate forming part of the shank, an electrical conductor including an insulation sheath and a supply conductor coupled to the contact plate to supply electrical energy to the jaw, and a jaw holder comprising a molded component overmolded onto portions of the shank, the contact plate, and the electrical conductor in a single shot. The molded component encapsulates and electrically insulates the contact plate and an exposed portion of the supply conductor.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
7.
METHODS OF OPERATING A SURGICAL INSTRUMENT OR A SUBSYSTEM THEREOF
Systems and subsystems for using a robotic instrument are disclosed. The method includes engaging a first closure input puck with a first closure robotic output. The method includes rotating the first closure robotic output to cause the first closure input puck to rotate. The method includes rotating a cam gear via the rotation of the first closure input puck. Rotation of the cam gear causes a yoke pin to track through a cam track in the cam gear, and the yoke pin is coupled to a closure tube. Tracking of the yoke pin through the cam track causes the yoke pin to translate from a first position to a second position, thereby translating the closure tube.
A surgical instrument designed to operate with a robotic platform is disclosed. The surgical instrument assembly includes a shaft, an end effector, a knife firing subsystem to actuate functions of the end effector, an articulation subsystem that is actuatable to articulate the end effector, an articulation joint about which the end effector articulates, a roll subsystem to roll the shaft, and a housing that couples to the robotic platform. A maypole tube is further provided, around which one or more articulation cables can wrap when the end effector is rotated.
A surgical instrument designed to operate with a robotic platform is disclosed. The surgical instrument assembly includes a shaft, an end effector, a knife firing subsystem to actuate functions of the end effector, an articulation subsystem that is actuatable to articulate the end effector, an articulation joint about which the end effector articulates, a roll subsystem to roll the shaft, and a housing that couples to the robotic platform.
A surgical instrument includes an end effector, a shaft assembly, a shank, and a clamp arm alignment structure. The end effector includes an ultrasonic blade and a clamp arm that can pivot relative to the ultrasonic blade between an open position and a closed position. The clamp arm includes an elongated coupling body. The shaft assembly includes an outer sheath and an ultrasonic waveguide. The shank is attached to the clamp arm and can pivot the clamp arm between the open position and the closed position. The shank includes a clamp arm support that can receive the elongated coupling body of the clamp arm in order to assist attachment of the clamp arm to the shank. The clamp arm alignment structure promotes alignment of the clamp arm relative to the ultrasonic blade in the closed position.
Systems and subsystems for cutting and stapling tissue are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument is a robotic attachment that includes a closure subsystem for a surgical instrument comprising a first closure input puck engageable with a first closure robotic output, a cam gear rotatably engaged with the first closure input puck, and a yoke pin coupled to a closure tube and movable from a first position to a second position in response to a rotation of the cam gear. Movement of the yoke pin from the first position to the second position translates the closure tube distally onto an anvil ramp of an anvil.
The present disclosure relates to systems, devices, and subsystems for robotic surgeries. The surgical instrument is a robotic attachment that includes an articulation subsystem comprising a rotatable shaft, a distal channel retainer coupled to an end effector that is pivotable about an articulation pivot point, an articulation bushing slidable between a proximal position and a distal position, an articulation rod extending distally from the articulation bushing and coupled at a distal end to the distal channel retainer; and a rack movable with respect to the longitudinal axis of the rotatable shaft. Movement of the rack with respect to the longitudinal axis imparts an axial force onto the articulation bushing moving the articulation bushing between the proximal position and the distal position. Movement of the articulation bushing between the distal position and the proximal position actuates the articulation rod causing the distal channel retainer to pivot about the articulation pivot point.
A robotic surgical tool that includes a plate inside of a drive housing. The drive housing is divided into an upper portion and lower portion by the plate. Extending from the drive housing is an elongate shaft. The robotic surgical tool also includes an injection port that passes a cleaning fluid into the drive housing. Inside the drive housing there is a diverter adjacent to the injection port. The diverter has a ramp which can direct fluid from the injection port to the upper portion of the drive housing.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
14.
FLUID MANAGEMENT SYSTEMS FOR ROBOTIC STAPLING AND CUTTING SYSTEMS
Systems and subsystems for cutting and stapling tissue are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The disclosed technology includes a housing for a surgical instrument configured to engage with a robotic arm. The housing comprises a first opening positioned to be engaged with at least a portion of a robotic arm, a second opening positioned proximate a rod extending from within the housing; and a fluid management system positioned within the housing proximate one of the first opening or the second opening, the fluid management system being configured to hold or divert fluid within the housing.
A surgical tool includes a drive housing, a drive input rotatably mounted to a bottom of the drive housing, a capstan assembly arranged within the drive housing and operatively coupled to the drive input such that rotation of the drive input correspondingly actuates the capstan assembly, a longitudinally driven gear engageable with the drive gear, a drive rod coupled to the longitudinally driven gear and extending from the drive housing to an end effector of the surgical instrument and at least one biasing member mounted to the drive housing and operatively coupled to at least one of the capstan assembly and the longitudinally driven gear. The biasing member biases the longitudinally driven gear toward a proximal position with a constant force.
Systems and subsystems for closing an end effector of a stapler are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument is a robotic attachment. The surgical instrument includes a closure subsystem that moves independently of other subsystems that are operable independently of each other.
Systems and subsystems for articulating an end effector of a stapler are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument is a robotic attachment. The surgical instrument includes an articulation subsystem that moves independently of other subsystems that are operable independently of each other.
A method includes receiving an electroanatomical (EA) map of at least a portion of a cardiac chamber. A quality is scored of an EA analysis of the EA map. Based on the scoring, one or more regions are identified in the mapped portion as failing to meet a defined quality criterion. The one or more regions are indicted on an EA map to be displayed to a user.
A61B 5/367 - Modalités électriques se rapportant au cœur, p.ex. électrocardiographie [ECG] Études électrophysiologiques [EEP], p.ex. cartographie de l’activation électrique ou cartographie électroanatomique
A61B 5/339 - Affichages spécialement adaptés à cet effet
The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p.ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p.ex. PEG, PPG, PEO ou polyglycérol
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c. à d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminée; Leurs dérivés contenant au moins une liaison peptidique anormale
C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
20.
END OF LIFE INDICATOR FOR ROBOTIC SURGICAL INSTRUMENTS
A surgical tool includes a drive housing, an indicator assembly arranged within the drive housing and actuatable to provide visual indication that the surgical tool has exhausted its useful life. The indicator assembly includes a drive input rotatably coupled to the bottom of the drive housing. The drive input further including a riser and a rim where the riser contains a passage therethrough. The indicator assembly further includes an indicator shaft extending through the passage along a longitudinal axis coaxially aligned with the drive input. The drive input is rotated to actuate the indicator assembly between a non-activated state, where the indicator shaft is recessed into the drive housing, and an activated state, where the indicator shaft extends out of the drive housing to provide the visual indication.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
The disclosed technology includes an irrigation tube for a medical catheter. The irrigation tube can include a flexible tube extending along a longitudinal axis from a proximal end to a distal end. The irrigation tube can include a pull wire attached to the flexible tube, the pull wire configured to deflect at least the distal end of the irrigation tube radially outward from the longitudinal axis. The irrigation tube can include an aperture proximate the distal end of the flexible tube, the aperture configured to direct an irrigation fluid outwardly from the irrigation tube so that irrigation fluid is directed generally in a direction of deflection by the pull wire.
A surgical instrument includes an end effector located at a distal end of a shaft and is selectively movable between an open configuration and a closed configuration. The end effector includes a guide with an ultrasonic blade (1142) extending therefrom and a clamp arm having a clamp pad (1146) and movable relative to the ultrasonic blade. The end effector further includes a tissue stop (1184) encircling the guide and having a leading surface. The tissue stop is configured to prevent tissue from moving proximally past the clamp pad during a closure stroke. In some versions, a leading surface of the tissue stop prevents tissue from moving proximally. The tissue stop may include a pair of deflectable flaps (1186) having the leading surface, wherein the deflectable flaps abut the clamp arm or other features of the end effector as the closure stroke is performed.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
23.
SURGICAL INSTRUMENT WITH CLAMP ARM AND PIVOT SHAFT HINGE COUPLING
A surgical instniment includes a body, a shaft assembly, an ultrasonic blade, and a clamp arm assembly. The shaft assembly extends distally from the body and includes an outer sheath and a first pivot portion such that the outer sheath and the first pivot portion are integrally formed together with each other as a first unitary piece. The clamp arm assembly includes a clamp arm and a second pivot portion such that the clamp arm and the second pivot portion are integrally formed together with each other as a second unitary piece. The clamp arm assembly is pivotally coupled to the shaft assembly via the first and second pivot portions.
A surgical instrument includes an end effector, a shaft assembly, a shank (5552), and a clamp arm alignment structure. The end effector includes an ultrasonic blade (5542) and a clamp arm that can pivot relative to the ultrasonic blade between an open position and a closed position. The clamp arm includes an elongated coupling body (5560). The shaft assembly includes an outer sheath (5532) and an ultrasonic waveguide. The shank (5552) is attached to the clamp arm and can pivot the clamp arm between the open position and the closed position. The shank includes a clamp arm support (5570) that can receive the elongated coupling body of the clamp arm in order to assist attachment of the clamp arm to the shank. The clamp arm alignment structure promotes alignment of the clamp arm relative to the ultrasonic blade in the closed position.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Embodiments of the present invention relate to methods of reducing oral toxicities, such as taste impairment, in subjects that undergo treatment with a GPRC5D- targeted therapeutic.
COMBINATION PRODUCTS OF AT LEAST THREE ANTIBIOTICS COMPRISING BEDAQUILINE, PRETOMANID OR DELAMANID, AND A CYTOCHROME BC1 INHIBITOR, AND THEIR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS
A61K 31/454 - Pipéridines non condensées, p.ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pimozide, dompéridone
A61K 31/5365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p.ex. 1,2-oxazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A surgical instrument designed to operate with a robotic platform is disclosed. The surgical instrument assembly includes a shaft, an end effector, a knife firing subsystem to actuate functions of the end effector, an articulation subsystem that is actuatable to articulate the end effector, an articulation joint about which the end effector articulates, a roll subsystem to roll the shaft, and a housing that couples to the robotic platform. The articulation subsystem includes an articulation joint that has a plurality of concentric discs and a center beam assembly. A distal end of the center beam assembly couples the plurality of concentric discs to the end effector. The proximal end of the center beam assembly couples the plurality of concentric discs to the shaft.
A surgical instrument designed to operate with a robotic platform is disclosed. The surgical instrument assembly includes a shaft, an end effector, a knife firing subsystem to actuate functions of the end effector, an articulation subsystem that is actuatable to articulate the end effector, an articulation joint about which the end effector articulates, a roll subsystem to roll the shaft, and a housing that couples to the robotic platform.
Systems and subsystems for cutting and stapling tissue are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument is a robotic attachment. The surgical instrument includes a closure subsystem, an articulation subsystem, a roll subsystem, and a transection subsystem that are operable independently of each other.
A medical system includes utility and ultrasound probes, and a processor. The probes are configured for operation inside an organ. The utility probe includes a distal end effector and a first sensor configured to output first signals indicative of first positions of the distal end effector. The ultrasound probe includes ultrasound transducer array configured to image volume comprising portion of the distal end effector inside the organ, and a second sensor configured to output second signals indicative of second positions of the ultrasound transducer array. The processor is configured to, using the imaged volume, and the first and second positions, select slices of the imaged volume that comprise at least part of distal end effector in spatial relation with the organ, generate from selected slices a biplane view and/or a triplane view of the part of the distal end effector, and present the biplane view and/or triplane view to user.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p.ex. en utilisant des cathéters
The disclosed technology includes electrode attachments for a medical probe, including an electrode body configured to deliver electrical energy to biological tissues. Elongated member(s) of the medical probe can include one or more apertures, and the electrode(s) can include one or more electrode apertures to align with the apertures of the elongated member. A pin is placed into the aligned apertures to secure the electrode to the elongated member.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
32.
TRANSECTION SUBSYSTEMS FOR ROBOTIC STAPLING AND CUTTING SYSTEMS
Systems and subsystems for cutting and stapling tissue are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument includes a transection subsystem comprising a rotatable shaft having a lumen, a firing rod extending at least partially through the lumen, a firing rack coupled to a proximal end of the firing rod, the firing rod being rotationally independent of the firing rack, and a firing gear engaged with the firing rack. Rotation of the firing gear moves the firing rack and the firing rod axially.
A method that includes selectively positioning an ablation catheter system at a treatment site comprising cardiac tissue, ablating cardiac tissue at the treatment site with the ablation catheter system using a power setting of approximately 90 W applied to tissue for approximately four (4) seconds to achieve a target electrode temperature, and achieving approximately zero incidence of steam pop occurrence in both left and right atrial ablations and complete pulmonary vein isolation, by the ablation catheter system, for all patients of a predetermined patient population suffering from paroxysmal atrial fibrillation (PAF).
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A surgical tool includes a shaft extending from a drive housing, an end effector including opposing jaws, and a wrist interposing the shaft and the end effector and including a distal clevis to which the jaws are rotatably mounted at a first axle, a proximal clevis rotatably mounted to the distal clevis at a second axle and operatively coupled to the shaft, a set of pulleys rotatably mounted to the second axle, and first and second redirect pulleys rotatably mounted to the distal clevis and axially interposing the pulleys and the jaws. A first closure cable extends through the pulleys to the first redirect pulley, which redirects the first closure cable with no fleet angle to the first jaw, and a second closure cable extends through the pulleys to the second redirect pulley, which redirects the second closure cable with no fleet angle to the second jaw.
An end effector for a surgical tool includes a jaw including a shank and a contact plate forming part of the shank, and a jaw holder secured to the jaw and providing a first molded component defining a cavity and a cable passage that communicates with the contact plate, a cable clip received within the cavity, and a second molded component overmolded onto the first molded component and at least a portion of the cable clip, and filling the cavity. An electrical conductor extends through the cable passage and includes an insulation sheath and a supply conductor electrically coupled to the contact plate to supply electrical energy to the jaw. The cable clip covers an exposed portion of the insulation sheath within the cavity, and the second molded component encapsulates and electrically insulates the contact plate and an exposed portion of the supply conductor.
A61B 17/29 - Pinces pour la chirurgie faiblement invasive
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/00 - Chirurgie assistée par ordinateur; Manipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A surgical instrument designed to operate with a robotic platform is disclosed. The surgical instrument assembly includes a shaft, an end effector, a knife firing subsystem to actuate functions of the end effector, an articulation subsystem that is actuatable to articulate the end effector, an articulation joint about which the end effector articulates, a roll subsystem to roll the shaft, and a housing that couples to the robotic platform. The roll subsystem can include a shaft assembly and a shaft roll puck assembly. The shaft assembly includes a rotatable outer shaft and an inner shaft. The shaft roll puck assembly engages the housing and includes a shaft roll puck and first and second screw gears. Rotation of the shaft roll puck rotates the first screw gear, which rotates the second screw gear, which rotates the rotatable outer shaft.
A phacoemulsification apparatus includes an ultrasound transmitter, an irrigation-aspiration tool, a robotic arm, and a processor. The ultrasound transmitter is configured to generate and focus an ultrasound beam into a lens capsule of an eye of a patient, to emulsify a lens of the eye. The irrigation-aspiration tool having a distal end including an outlet of an irrigation channel for flowing irrigation fluid into the lens capsule, and an inlet of an aspiration channel for removing material from the lens capsule. The robotic arm is configured to move the distal end of the irrigation-aspiration tool inside the lens capsule. The processor is configured to control the ultrasound transmitter to irradiate one or more target locations in the eye capsule with the focused ultrasound beam, and control the robotic arm to move the distal end of the irrigation-aspiration tool in coordination with the target locations irradiated by the ultrasound transmitter.
A61B 34/20 - Systèmes de navigation chirurgicale; Dispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p.ex. pour la stéréotaxie sans cadre
A surgical tool includes a drive housing, a drive input rotatably mounted to a bottom of the drive housing, a capstan assembly arranged within the drive housing to rotate a drive gear about a rotational axis and within a drive plane orthogonal to the rotational axis, a longitudinally driven gear engageable with the drive gear, and a drive rod operatively coupled to the longitudinally driven gear and extending from the drive housing to a knife extendable within end effector of the surgical instrument. The drive rod is aligned within the drive plane such that translation of the longitudinally driven gear induces a corresponding longitudinal translation of the drive rod within the drive.
A method of inserting a fastener into a fusion cage can include attaching a fastener head of a bone fastener to a flexible bone fastener driver. The method can also include inserting the bone fastener into a threaded throughhole of a fusion cage comprising a front wall, a pair of opposing side walls, a back wall, and top and bottom surfaces adapted for gripping opposed vertebral endplates, wherein the front wall comprises the threaded throughhole.
A surgical instrument includes an ultrasonic blade assembly, a sheath, a first mating feature, and an overmolded distal pipe (2034). The ultrasonic blade assembly extends distally along a longitudinal axis from a waveguide to an ultrasonic blade (2041). Sheath is positioned over the ultrasonic blade assembly. The first mating feature is positioned on at least one of the sheath or the ultrasonic blade assembly. The overmolded distal pipe extends distally from the sheath with a second mating feature configured to be adhered to the first mating feature.
Provided are methods of treating an epidermal growth factor receptor (EGFR)-expressing or hepatocyte growth factor receptor (c-Met)-expressing cancer in a subject in need thereof. The methods comprise administering to the subject a therapy comprising an isolated bispecific anti- EGFR/c-Met antibody, wherein the administration comprises a dose of about 1400-2100 mg, administered once per a 21 -day cycle.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
An ultrasonic instrument includes a body and a shaft assembly extending distally from the body. The shaft assembly includes an acoustic waveguide. The instrument further includes an end effector including an ultrasonic blade. The ultrasonic blade is in acoustic communication with the acoustic waveguide. The instrument further includes a sensor configured to sense at least one characteristic of the shaft assembly and/or the end effector. The end effector is configured to be activated at varying power levels based on the at least one characteristic sensed by the sensor.
A method of replacing a surgical tool consumable, the surgical tool including a drive housing containing an ultrasonic transducer, a shaft extending distally from the drive housing, an end effector coupled to the shaft and including a blade operatively coupled to the ultrasonic transducer and extending from drive housing within the shaft, and a clamp assembly that includes a clevis extending about the blade and a clamp arm pivotably coupled to the clevis such that axial movement of the clevis causes the clamp arm to move between open and closed positions, and a wrist interposing the shaft and the end effector. The method further including decoupling the blade from the ultrasonic transducer, removing the end effector from the wrist and proximal portions of the surgical tool, replacing the consumable of the surgical tool, and reconnecting the end effector to the wrist and the proximal portions of the surgical tool.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
The present invention relates to methods of manufacture for producing anti-TNF antibodies, e.g., the anti-TNF antibody a recombinant anti-TNF antibody having a heavy chain (HC) comprising amino acid sequence SEQ ID NO:36 and a light chain (LC) comprising amino acid sequence SEQ ID NO:37 and compositions comprising the recombinant anti-TNF antibody.
C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
The present invention relates to improved contact lens packages and methods of use. A contact lens package (100) may include a base (110) and a lid (140) connected to the base. The base may include a base cavity (124) that houses a contact lens (150) and packaging solution, and a slot (130) extending through the base from an internal surface (132) to an external surface (134) of the base and in communication with the base cavity. The lid may extend over the external surface of the base and cover the slot when the package is in an unopened state, and the lid may not cover the slot when the package is in an opened state, such that the contact lens is accessible to a user through the slot when the package is in the opened state.
B65D 85/00 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers
B65D 81/22 - Réceptacles, éléments d'emballage ou paquets pour contenus présentant des problèmes particuliers de stockage ou de transport ou adaptés pour servir à d'autres fins que l'emballage après avoir été vidés de leur contenu fournissant une ambiance spécifique pour le contenu, p.ex. température supérieure ou inférieure à la température ambiante en condition d'humidité ou immergés dans un liquide
Arcuate fixation members with varying configurations and/or features are provided, along with additional components for use therewith in provided intervertebral implants. The arcuate fixation members may be of different lengths, cross sectional geometries, and/or cross sectional areas. Applications of intervertebral implants utilizing arcuate fixation members are particularly suitable when a linear line-of-approach for delivering fixation members is undesirable.
An apparatus includes a base, an actuator, and a clamp member. The actuator is pivotably coupled with the base. The clamp member is operable to selectively clamp a malleable guide rail relative to the base. The guide rail is configured to fit in an anatomical passageway in a head of a patient. The actuator is operable to pivot relative to the base to thereby bend the guide rail while the guide rail is clamped by the clamp member.
A method is disclosed. The method includes delivering staples from a surgical staple cartridge of a surgical instrument to a first tissue during a first procedure; removing the surgical staple cartridge from the surgical instrument; and delivering radio-frequency energy from a radio-frequency cartridge of the surgical instrument to a second tissue during a second procedure.
A61B 17/29 - Pinces pour la chirurgie faiblement invasive
A61B 17/295 - Pinces pour la chirurgie faiblement invasive combinées à des instruments coupants
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p.ex. des courants à haute fréquence
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A method for treating an articular fracture of a tibia using a tibia plate with an extension arm, including: making an incision to expose the tibia; reducing the articular fracture of the tibia; contouring the tibia plate to fit the tibia; preliminarily fixing the tibia plate to the tibia; placing a screw partially into the tibia through a lateral elongated hole in the tibia plate; applying compression between a plate screw hole in the extension arm and an anterior surface of the tibia; and placing additional plate screws in the tibia through additional screw holes in the tibia plate.
Systems, methods, and devices for selectively adjustable data exchange are provided. In an aspect, an assembly including a protective container having a medical device disposed therein is provided. The protective container can be sealed to prevent contaminates from contacting the medical device. The assembly can further include a radiofrequency identification (RFID) tag disposed within the protective container. The RFID can include a data processor and memory storing first data and instructions configured to cause the data processor to perform operations. The operations can include receiving request data from a remote network in operable communication with the RFID. The request data can characterize a query for the first data stored in the memory to be provided to the remote network. The operations can include determining a subset of the data based on the received request data and a data transfer rule stored in the memory. The operations can further include providing the determined subset of the first data to the remote network.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
51.
SYSTEMS AND METHODS FOR STORAGE AND TRANSFER OF SMART PACKAGING METADATA
Systems and methods are provided. The systems include a manufacturer-sealed sterile surgical packaging containing a surgical instrument configured to be used in a surgical procedure and memory in operable communication with the at least one data processor, and storing instructions configured to cause the at least one data processor to perform operations. The operations can include recording historical data points of the surgical instrument, determining a degradation level of the surgical instrument based on the historical data point, determining an altered set of operating parameters based on the degradation level of the surgical instrument, and providing the altered set of operating parameters.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des moyens électromagnétiques, p.ex. transpondeurs
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
52.
SITUATIONALLY ADAPTIVE LABELING FOR SMART PACKAGING SYSTEMS
Systems and methods are provided. The systems include a manufacturer-sealed sterile surgical packaging containing a surgical instrument, a graphical display disposed on the manufacturer- sealed sterile surgical packaging, a data processor disposed in the surgical packaging, and memory in operable communication with the data processor, the memory storing instructions configured to cause the at least one data processor to perform operations. The operations include storing a plurality of display information sets corresponding to the surgical instrument, receiving a data set including a stage along a supply chain progression, determining, based on the received location along the supply-chain progression, a graphical depiction characterizing at least one of the plurality of stored display information sets, and providing the graphical depiction of the determined at least one display information set on the graphical display.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G06Q 10/08 - Logistique, p.ex. entreposage, chargement ou distribution; Gestion d’inventaires ou de stocks
G06Q 10/0631 - Planification, affectation, distribution ou ordonnancement de ressources d’entreprises ou d’organisations
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p.ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
53.
SMART PACKAGING SYSTEMS WITH NONVOLATILE RESILIENT STORE
Systems and methods are provided. The systems include a manufacturer-sealed sterile surgical packaging containing a surgical instrument configured to be used in a surgical procedure, a graphical display, at least one data processor in operable communication with the graphical display, and memory in operable communication with the at least one data processor, and storing instructions configured to cause the at least one data processor to perform operations. The operations can include storing parameters corresponding to the surgical instrument, receiving a data set characterizing parameters associated with the surgical instrument, adjusting based on the received data, the catalogued parameters, determining a graphical depiction characterizing the adjusted parameters, and providing the graphical depiction of the adjusted parameters on the graphical display.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p.ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante
54.
SYSTEM AND METHOD FOR SELECTIVELY ADJUSTABLE DATA EXCHANGE BETWEEN A SMART PACKAGE AND A REQUESTING SYSTEM
Systems, methods, and devices for selectively adjustable data exchange are provided. In an aspect, an assembly including a protective container having a medical device disposed therein is provided. The protective container can be sealed to prevent contaminates from contacting the medical device. The assembly can further include a radiofrequency identification (RFID) tag disposed within the protective container. The RFID can include a data processor and memory storing first data and instructions configured to cause the data processor to perform operations. The operations can include receiving request data from a remote network in operable communication with the RFID. The request data can characterize a query for program data characterizing executable instructions to cause a remote processor to perform operations for configuring an operating system to operate the medical device, and further including data characterizing information about the remote network and/or the operating system. The operations can include determining, the program data characterizing executable instructions configured to cause a remote processor to perform operations for configuring an operating system to operate the medical device based on the received request data. The operations can further include providing the program data to the remote network.
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des moyens électromagnétiques, p.ex. transpondeurs
Systems and methods for sensing tissue in a phacoemulsification procedure are provided herein. A method may include generating a sensing signal through a frequency range centered at a local resonant frequency of an ultrasonic handpiece and measuring impedance characteristics of the signal at a distal end of a needle of an ultrasonic handpiece. A method may further include comparing the measured impedance characteristics of the generated sensing signal with one or more stored impedance profiles. A method may further include classifying, based on the comparison between the measured impedance characteristics and the stored one or more impedance profiles, a medium contacting the distal end of the needle. A method may further include controlling an output of the ultrasonic handpiece based on the classification of the medium contacting the tip of the needle.
A system, method and computer program product, the system comprising : a phacoemulsification probe having a needle at its distal end, the needle configured to be inserted into an eye of a patient; a pressure sensor; and a processor, configured to repeatedly: obtain a plurality of pressure values taken by the pressure sensor, each of the plurality of pressure values indicating an intraocular pressure (IOP) measurement taken during a surgical procedure; calculate an overall measurement for the surgical procedure based on the pressure values; and displaying on a display device a graphic representation of the overall measurement.
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
57.
Methods for Producing Anti-TNF Antibody Compositions
Presented here are methods for producing a recombinant anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO:38 and a light chain (LC) comprising SEQ ID NO:37 and compositions comprising the recombinant anti-TNF antibody.
C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
58.
LIGHT-BASED VISUAL CUEING OF MEDICATION DELIVERY INSTRUCTIONS
A wireless receiver may be configured to receive a plurality of wireless communications from a computing device. A first light source may be activated based on a first wireless communication of the plurality of wireless communications. Activating of the first light source may be a first visual cue to perform a first step of a plurality of steps of instructions for use of a medication delivery device, and the first light source may be activated in correspondence with the first step being displayed by the computing device. A second light source may be activated based on a second wireless communication of the plurality of wireless communications. Activating of the second light source may be a second visual cue to perform a second step of the plurality of steps, and the second light source may be activated in correspondence with the second step being displayed by the computing device.
A61M 5/20 - Seringues automatiques, p.ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
59.
SYSTEMS AND METHODS FOR MASS AIR FLOW CONTROL IN VACUUM BASED ASPIRATION IN SURGICAL SYSTEM
A surgical system for the treatment of ocular problems including a surgical cassette, a surgical console operatively coupled to the surgical cassette and further including a processor, a vacuum source positioned in-line with a vacuum regulator and a mass air flow controller, and a tank fluidly connected to the mass air flow controller, wherein the processor is configured to calculate an air flow set point in accordance with a received at least one user-defined fluid flow rate set point; and wherein the mass air flow controller modulates air flow from the tank to the vacuum source in accordance with the received the air flow set point to meet a user-defined fluid flow rate.
A system, method and computer program product, the system comprising: a phacoemulsification probe having a needle at its distal end, the needle configured to be inserted into an eye of a patient; a pressure sensor, and a processor, configured to repeatedly: obtain a plurality of pressure values taken by the pressure sensor, each of the plurality of pressure values indicating an intraocular pressure (IOP) measurement taken during a surgical procedure; calculate an overall measurement for the surgical procedure based on the pressure values; and displaying on a display device a graphic representation of the overall measurement.
Provided is a method for manufacturing photoabsorbing contact lenses and photoabsorbing contact lenses produced thereby. The method comprises: (a) providing a mold assembly comprised of a base curve and a front curve, the base curve and the front curve defining and enclosing a cavity therebetween, the cavity containing a reactive mixture, wherein the reactive mixture comprises at least one polymerizable monomer, a photoinitiator which absorbs at an activating wavelength, and a photoabsorbing compound which displays absorption at the activating wavelength; and (b) curing the reactive mixture to form the photoabsorbing contact lens by exposing the reactive mixture to radiation that includes the activating wavelength, wherein the radiation is directed at both the base curve and the front curve of the mold assembly, and wherein the radiation's radiant energy at the base curve is greater than the radiation's radiant energy at the front curve.
B29D 11/00 - Fabrication d'éléments optiques, p.ex. lentilles ou prismes
B29K 33/00 - Utilisation de polymères d'acides non saturés ou de leurs dérivés comme matière de moulage
B29K 83/00 - Utilisation de polymères contenant dans la chaîne principale uniquement du silicium avec ou sans soufre, azote, oxygène ou carbone comme matière de moulage
B29K 105/00 - Présentation, forme ou état de la matière moulée
An apparatus includes a shaft and an inflatable sleeve catheter. The shaft is configured for insertion through a sheath into a cavity of an organ of a patient. The inflatable sleeve catheter is fixed to a distal end of the shaft, with the inflatable sleeve catheter including (i) a resilient inner end section, which is fixed to the distal end of the shaft and is formed so as to assume a predefined shape when unconstrained, (ii) an inflatable sleeve that envelopes the inner end section, and a plurality of electrodes that are disposed over the inflatable sleeve and are configured to contact tissue.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
63.
SURGICAL STAPLER END EFFECTOR SLED HAVING CARTRIDGE WALL SUPPORT FEATURE
A staple driver actuator for a surgical stapler includes a base having at least one bottom surface. The bottom surface defines a plane and is configured to slide longitudinally relative to a jaw of the surgical stapler. The staple driver actuator also includes a plurality of rails extending upwardly from the base. Each of the plurality of rails includes at least one cam surface, and each of the cam surfaces is inclined relative to the plane. The plurality of rails includes a laterally-opposed pair of outer rails and a laterally-opposed pair of inner rails. The staple driver actuator further includes a distal nose extending distally from at least a portion of the base and having at least one ledge surface. The ledge surface faces upwardly, is parallel to the plane, and is at least partially positioned distally relative to each of the outer and inner rails.
An apparatus includes a base, an actuator, and a clamp member. The actuator is pivotably coupled with the base. The clamp member is operable to selectively clamp a malleable guide rail relative to the base. The guide rail is configured to fit in an anatomical passageway in a head of a patient. The actuator is operable to pivot relative to the base to thereby bend the guide rail while the guide rail is clamped by the clamp member.
B21D 7/024 - Cintrage des barres, profilés ou tubes par utilisation d'un organe de formage ou d'une butée oscillante par un organe de formage oscillant
Systems and methods are provided. The systems can include at least one primary packaging, at least one graphical display disposed on the primary packaging, and an electronic management system in electronic communication with the primary packaging. The electronic management system is configured to receive data characterizing a list of compatible secondary packagings stored on the primary packaging, determine a compatible secondary packaging in electronic communication with the electronic management system from the list of compatible secondary packagings stored on the primary packaging, and provide data characterizing the determined compatible secondary packaging on the at least one graphical display of the primary packaging.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
66.
SYSTEMS AND METHODS FOR THE CREATION AND MANAGEMENT OF VIRTUAL KITS
Surgical systems and methods are provided. The surgical systems include at least one primary surgical system, and an electronic management system in electronic communication with the primary surgical system. The electronic management system is configured to update a virtual compatibility list stored on a primary surgical system with compatibility information, create a first virtual kit for a surgical procedure, and provide the first virtual kit. The compatibility information characterizes a level of compatibility between the primary surgical system and one or more secondary surgical systems in electronic communication with the electronic management system. The first virtual kit including the primary surgical system and at least one of the one or more secondary surgical systems selected based upon the compatibility list.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
67.
IDENTIFICATION SYSTEMS AND METHODS FOR SMART PACKAGING SYSTEMS
Systems and methods are provided. The systems include a manufacturer-sealed, sterile surgical packaging, a surgical instrument stored within the manufacturer-sealed, sterile packaging, a first transceiver contained within the manufacturer-sealed, sterile surgical packaging and configured to transmit a first data set including a first amount of data, a second transceiver contained within the manufacturer-sealed, sterile surgical packaging and configured to transmit a second data set including a second amount of data, the second amount of data greater than the first amount of data, and a power supply contained within the manufacturer-sealed and connected to the second transceiver, wherein the second transceiver is intermittently powered by the power supply.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61B 42/00 - Gants chirurgicaux; Doigtiers spécialement adaptés à la chirurgie; Dispositifs pour leur manipulation ou leur traitement
A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes
Packaging and methods are provided. The packaging includes a manufacturer-sealed, sterile surgical package, a surgical instrument stored within the manufacturer-sealed, sterile package; and at least one secondary-use package contained within the manufacturer-sealed, sterile surgical package. The at least one secondary-use package is configured to receive and sterilely contain one or more components of the surgical instrument following the surgical procedure. The at least one secondary-use package includes at least one authenticator configured to selectively allow access to the at least one secondary-use package.
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des moyens électromagnétiques, p.ex. transpondeurs
69.
SYSTEM AND METHOD FOR SELECTIVELY ADJUSTABLE DATA EXCHANGE BETWEEN A SMART PACKAGE AND A REQUESTING SYSTEM
Systems, methods, and devices for selectively adjustable data exchange are provided. In an aspect, an assembly including a protective container having a medical device disposed therein is provided. The protective container can be sealed to prevent contaminates from contacting the medical device. The assembly can further include a radiofrequency identification (RFID) tag disposed within the protective container. The RFID can include a data processor and memory storing first data and instructions configured to cause the data processor to perform operations. The operations can include receiving request data from a remote network in operable communication with the RFID. The request data can characterize a future data processing operation to be performed on a subset of the first data after the subset is transmitted from the RFID tag, and a request for the subset of the first data to be transmitted from the RFID tag to the remote network. The operations can include determining the subset of the first data to be provided to the remote network. The operations can further include providing the determined subset of the data to the remote network.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des moyens électromagnétiques, p.ex. transpondeurs
G06Q 10/08 - Logistique, p.ex. entreposage, chargement ou distribution; Gestion d’inventaires ou de stocks
G06Q 10/087 - Gestion d’inventaires ou de stocks, p.ex. exécution des commandes, approvisionnement ou régularisation par rapport aux commandes
Surgical systems and methods are provided. The surgical systems include at least one manufacturer-sealed sterile surgical package containing a surgical instrument, and an electronic management system in electronic communication with the at least one manufacturer-sealed sterile surgical package. The electronic management system is configured to receive inventory data characterizing inventory information of the manufacturer-sealed sterile surgical package, update a master management list with the received inventory data, determine, based on the updated master management list, a procedure inventory list for a surgical procedure utilizing the surgical instrument, the procedure inventory list including surgical equipment needed for the surgical procedure, provide the procedure inventory list.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
G06Q 10/08 - Logistique, p.ex. entreposage, chargement ou distribution; Gestion d’inventaires ou de stocks
G06Q 10/087 - Gestion d’inventaires ou de stocks, p.ex. exécution des commandes, approvisionnement ou régularisation par rapport aux commandes
71.
SYSTEMS AND METHODS FOR DEVICE HISTORY DOCUMENTATION
Surgical systems and methods are provided. The surgical systems include a manufacturer-sealed sterile surgical package containing a surgical instrument, at least one data processor, and memory storing instructions configured to cause the at least one data processor to perform operations. The operations include update a historical record of the surgical package and/or the surgical instrument based on at least one of a current geo-political location and a supply-chain progression of the surgical system, and provide, based on at least one of the current geo-political location and the supply-chain progression of the surgical system, handling instructions for the surgical system.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
72.
SYSTEMS AND METHODS FOR DETERMINATION OF SURGICAL DEVICE COMPATIBILITY
Surgical systems and methods are provided. The surgical systems include a manufacturer-sealed sterile surgical package containing a surgical instrument, at least one data processor, and memory storing instructions configured to cause the at least one data processor to perform operations. The operations include receive, from a remote server, data characterizing one or more aspects of a surgical procedure involving the surgical instrument, determine a level of compatibility of the surgical instrument with each of the one or more aspects of the surgical procedure, provide the determined level of compatibility.
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p.ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des moyens électromagnétiques, p.ex. transpondeurs
Surgical systems and methods are provided. The surgical systems include a manufacturer- sealed, sterile surgical package containing a surgical instrument, at least one data processor, and memory storing instructions configured to, prior to breach of the manufacturer-sealed sterile surgical package, cause the at least one data processor to perform operations. The operations include receive, from a remote server, data characterizing a geo-political location of at least one of the surgical package and the surgical instrument, and transmit instructions, based on the received data, to at least one of the surgical package and the surgical instrument to alter one or more aspects of the surgical package and/or the surgical instrument.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p.ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p.ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante
74.
SURGICAL SYSTEMS WITH INTERACTIVE HANDLING AND DISPOSAL GUIDANCE
Surgical systems and methods are provided. The surgical systems include a manufacturer-sealed sterile surgical package containing a surgical instrument configured to be used in a surgical procedure, at least one data processor, and memory storing instructions configured to cause the at least one data processor to perform operations. The operations include catalogue components of the surgical instrument, determine disposal procedures for each of the components of the surgical instrument, and provide the disposal procedures at the end of the surgical procedure.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
75.
Motor control of surgical stapler with controlled impact at end of firing stroke
A software for driving a motor in a powered surgical stapler can include a pausing monitoring process that may be effective to improve staple form and/or increase localized compression of tissue. The pausing monitoring process monitors firing speed of a firing bar driving by the motor and pauses the motor when the firing speed passes a speed error threshold. Before pausing the motor, the pausing monitoring process may also require that a pulse width modulated (PWM) electrical signal driving the motor has a duty cycle over a duty cycle threshold while the firing speed is beyond the speed error. The pausing monitoring process may force the firing bar through a predetermined distance immediately after pausing. The pausing monitoring process may be limited in the number of pauses that can be taken during a firing stroke.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
A61B 17/29 - Pinces pour la chirurgie faiblement invasive
A61B 34/00 - Chirurgie assistée par ordinateur; Manipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des moyens électromagnétiques, p.ex. transpondeurs
A surgical stapling end effector comprising a cartridge channel jaw, an anvil jaw, and a surgical staple cartridge positioned within the cartridge channel jaw is disclosed. The surgical staple cartridge comprises a plurality of staples, a cartridge body comprising a plurality of staple cavities, a longitudinal slot, and an outer lateral cartridge wall comprising a recess defined therein. The surgical staple cartridge further comprises an electronics sub-assembly positioned within the recess, wherein the electronics sub-assembly comprises electrical pathways, a printed circuit board removably attached to the outer lateral cartridge wall within the recess, and a wireless transmission coil electrically coupled to the printed circuit board by way of the electrical pathways, wherein the wireless transmission coil is configured to transmit at least one of power or data between the printed circuit board and a corresponding wireless transmission coil of an instrument to which the surgical staple cartridge is attached.
Surgical systems and methods are provided. The surgical systems include a manufacturer-sealed sterile surgical package containing a surgical instrument configured to be used in a surgical procedure, at least one data processor, and memory storing instructions configured to cause the at least one data processor to perform operations. The operations include catalogue components of the surgical instrument, determine disposal procedures for each of the components of the surgical instrument, and provide the disposal procedures at the end of the surgical procedure.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
G08B 5/36 - Systèmes de signalisation optique, p.ex. systèmes d'appel de personnes, indication à distance de l'occupation de sièges utilisant une transmission électromécanique utilisant des sources de lumière visible
Surgical systems and methods are provided. The surgical systems include at least one manufacturer-sealed sterile surgical package containing a surgical instrument, and an electronic management system in electronic communication with the at least one manufacturer-sealed sterile surgical package. The electronic management system is configured to receive inventory data characterizing inventory information of the manufacturer-sealed sterile surgical package, update a master management list with the received inventory data, determine, based on the updated master management list, a procedure inventory list for a surgical procedure utilizing the surgical instrument, the procedure inventory list including surgical equipment needed for the surgical procedure, provide the procedure inventory list.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
Surgical systems and methods are provided. The surgical systems include a manufacturer-sealed, sterile surgical package containing a surgical instrument, at least one data processor, and memory storing instructions configured to, prior to breach of the manufacturer-sealed sterile surgical package, cause the at least one data processor to perform operations. The operations include receive, from a remote server, data characterizing a geo-political location of at least one of the surgical package and the surgical instrument, and transmit instructions, based on the received data, to at least one of the surgical package and the surgical instrument to alter one or more aspects of the surgical package and/or the surgical instrument.
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
Packaging and methods are provided. The packaging includes a manufacturer-sealed, sterile surgical package, a surgical instrument stored within the manufacturer-sealed, sterile package; and at least one secondary-use package contained within the manufacturer-sealed, sterile surgical package. The at least one secondary-use package is configured to receive and sterilely contain one or more components of the surgical instrument following the surgical procedure. The at least one secondary-use package includes at least one authenticator configured to selectively allow access to the at least one secondary-use package.
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des moyens électromagnétiques, p.ex. transpondeurs
82.
SMART PACKAGING SYSTEMS WITH NONVOLATILE RESILIENT STORE
Systems and methods are provided. The systems include a manufacturer-sealed sterile surgical packaging containing a surgical instrument configured to be used in a surgical procedure, a graphical display, at least one data processor in operable communication with the graphical display, and memory in operable communication with the at least one data processor, and storing instructions configured to cause the at least one data processor to perform operations. The operations can include storing parameters corresponding to the surgical instrument, receiving a data set characterizing parameters associated with the surgical instrument, adjusting based on the received data, the catalogued parameters, determining a graphical depiction characterizing the adjusted parameters, and providing the graphical depiction of the adjusted parameters on the graphical display.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
83.
SYSTEMS AND METHODS FOR STORAGE AND TRANSFER OF SMART PACKAGING METADATA
Systems and methods are provided. The systems include a manufacturer-sealed sterile surgical packaging containing a surgical instrument configured to be used in a surgical procedure, a graphical display, at least one data processor in operable communication with the graphical display, and memory in operable communication with the at least one data processor, and storing instructions configured to cause the at least one data processor to perform operations. The operations can include recording historical data points of the surgical instrument, determining a degradation level of the surgical instrument based on the historical data point, determining an altered set of operating parameters based on the degradation level of the surgical instrument, and providing the altered set of operating parameters.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
84.
SITUATIONALLY ADAPTIVE LABELING FOR SMART PACKAGING SYSTEMS
Systems and methods are provided. The systems include a manufacturer-sealed sterile surgical packaging containing a surgical instrument, a graphical display disposed on the manufacturer-sealed sterile surgical packaging, a data processor disposed in the surgical packaging, and memory in operable communication with the data processor, the memory storing instructions configured to cause the at least one data processor to perform operations. The operations include storing a plurality of display information sets corresponding to the surgical instrument, receiving a data set including a stage along a supply chain progression, determining, based on the received location along the supply-chain progression, a graphical depiction characterizing at least one of the plurality of stored display information sets, and providing the graphical depiction of the determined at least one display information set on the graphical display.
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p.ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante
85.
COOPERATIVE AND COLLABORATIVE LABELING AND PACKAGING OF SMART PACKAGING SYSTEMS
Systems and methods are provided. The systems can include at least one primary packaging, at least one graphical display disposed on the primary packaging, and an electronic management system in electronic communication with the primary packaging. The electronic management system is configured to receive data characterizing a list of compatible secondary packagings stored on the primary packaging, determine a compatible secondary packaging in electronic communication with the electronic management system from the list of compatible secondary packagings stored on the primary packaging, and provide data characterizing the determined compatible secondary packaging on the at least one graphical display of the primary packaging.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p.ex. pour planifier la maintenance ou les mises à jour
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
A61J 1/18 - Dispositions pour indiquer l'état, p.ex. l'état stérile, du contenu du récipient
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
A61K 31/4745 - Quinoléines; Isoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. phénanthrolines
A61K 31/475 - Quinoléines; Isoquinoléines ayant un cycle indole, p.ex. yohimbine, réserpine, strychnine, vinblastine
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p.ex. prégnane ou progestérone substitués en position 21, p.ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p.ex. phosphate de pyridoxal
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p.ex. phloridzine liés à un système carbocyclique condensé, p.ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A method of treating active Systemic Lupus Erythematosus (SLE) in a patient by administering a clinically proven safe and clinically proven effective amount of an anti-IL-12/IL-23p40 antibody or an anti-IL-23 antibody, e.g., the anti-IL-12/IL-23p40 antibody ustekinumab, wherein the patient achieves a significant improvement in disease activity.
C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61K 47/18 - Amines; Amides; Urées; Composés d’ammonium quaternaire; Acides aminés; Oligopeptides ayant jusqu’à cinq acides aminés
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 37/06 - Immunosuppresseurs, p.ex. médicaments pour le traitement du rejet de greffe
Systems and methods for sensing tissue in a phacoemulsification procedure are provided herein. A method may include generating a sensing signal through a frequency range centered at a local resonant frequency of an ultrasonic handpiece and measuring impedance characteristics of the signal at a distal end of a needle of an ultrasonic handpiece. A method may further include comparing the measured impedance characteristics of the generated sensing signal with one or more stored impedance profiles. A method may further include classifying, based on the comparison between the measured impedance characteristics and the stored one or more impedance profiles, a medium contacting the distal end of the needle. A method may further include controlling an output of the ultrasonic handpiece based on the classification of the medium contacting the tip of the needle.
A position sensor for measuring signals indicative of location and/or orientation a catheter's distal end, and a method of fabrication thereof are disclosed. The position sensor includes a flexible circuit board (FCB) and at least three surface mount coil devices (SMD coils) arranged thereon for sensing different aspects of one or more magnetic fields, which are indicative of the location and/or orientation of the catheters distal end. The FCB is furnished at the sensor in folded/rolled state such that the magnetic flux axes of at least three of the SMD coils are not co-planar to thereby enable utilizing signals measured thereby determine the at least one of the orientation and location of the sensor relative to one or more magnetic field sources.
The presently disclosed subject matter includes computer methods and computer systems that enable to select and provide a suitable treatment for AF patients that increases the likelihood of long-term amelioration of AF conditions, and thereby enhances treatment of AF patients. The disclosure provides methods and systems for analysis of the condition of AF patients and the tailoring of personalized treatment regimens based on various AF features obtained from the patients, and the determination of a treatment selected from at least PVI only and PVI plus. To overcome technical difficulties resulting from scarcity of data a machine learning model that is trained using physician recommendation rather than observed treatment outcome is disclosed.
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
91.
LEFT ATRIAL APPENDAGE (LAA) TRANSSEPTAL ACCESS POINT OPTIMIZATION
A method includes, using a processor, identifying a septum and a Left Atrium Appendage (LAA) of a heart of a patient in an anatomical map of at least part of the heart. An entry surface over which a medical device is defined on the anatomical map, which is to be delivered via a sheath that penetrates the septum, is to engage with the LAA. A normal to the entry surface is calculated. A plurality of curves is calculated that each (i) have one end that is tangent to the normal, (ii) have a second end touching the septum, and (iii) comply with specified mechanical properties of the sheath. Multiple candidate locations on the septum are derived from the curves, for transseptal puncture with the sheath. The multiple candidate locations are presented to a user.
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p.ex. en utilisant des cathéters
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical
In some embodiments, an apparatus can include a robotic arm cart for transporting, delivering, and securing robotic arms to a surgical table having a table top. The arm cart can include an arm container and a base. The arm container can be configured to receive and contain one or more robotic arms. The arm cart can include a first coupling member configured to engage with a second coupling member associated with a surgical table such that, when the first coupling member is engaged with the second coupling member, the one or more robotic arms can be releasably coupled with the surgical table. The arm cart can provide for movement of the one or more robotic arms in at least one of a lateral, longitudinal, or vertical direction relative to the table top prior to the securement of the one or more robotic arms to the surgical table.
B62B 3/02 - Voitures à bras ayant plus d'un essieu portant les roues servant au déplacement; Dispositifs de direction à cet effet; Appareillage à cet effet comportant des parties réglables, rabattables, attachables, détachables ou transformables
93.
1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS
The invention relates to pharmaceutical compounds and pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as inhibitors of the SMARCA2 protein and to their use in the treatment of SMARCA4 deficient cancers, e.g., SMARCA4 deficient non-small cell lung cancer (NSCLC).
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. quinolizines, naphtyridines, berbérine, vincamine
94.
BIOSYNTHETIC MONOVALENT BINDING MOLECULES WITH ENHANCED EFFECTOR FUNCTIONS
Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is monovalent and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to the EU numbering system; wherein the binding molecule has increased capability of hexamerization on a cell surface, and/or increased capability of engaging C1q.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
95.
Anti-CD38 Antibodies for Treatment of Light Chain Amyloidosis and Other CD38-Positive Hematological Malignancies
The present invention relates to methods of treatment of light chain amyloidosis and other CD38-positive hematological malignancies with anti-CD38 antibodies.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p.ex. prégnane ou progestérone substitués en position 21, p.ex. cortisone, dexaméthasone, prednisone ou aldostérone
The present invention relates to compositions and methods utilizing anti-TNF antibodies having a heavy chain (HC) comprising SEQ ID NO:36 and a light chain (LC) comprising SEQ ID NO:37 for use in the safe and effective treatment of active Psoriatic Arthritis (PsA).
C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
The present invention relates to improved contact lens packages comprising arms and methods of use. A contact lens package (100) houses a contact lens (138) and packaging solution and is configured to lift via arms (134, 144) the contact lens out of the packaging solution when the lid (106) is removed.
A bone plate defines an interior surface that defines: a hole extending through the plate along an axis; plate threads configured for locking with a threaded head of a locking screw; first, second, and third columns sequentially located about the axis; a first corner extending tangentially from the second to the first column; and a second corner extending tangentially from the third to the first column. The first and second corners are substantially equidistantly spaced from the axis. The plate threads extend across the first, second, and third columns and the first and second corners. The interior surface defines a recess between the second and third columns and facing the first column. An apex of the recess is spaced further from the axis than are the first and second corners, such that the recess circumferentially interrupts at least a portion of at least one of the plate threads.
An interbody fusion cage having upper and lower canals for receiving the heads of bone screws that have been pre-installed in opposing vertebral body endplates. The proximal wall of the cage preferably has a vertical slot that communicates with each canal and is adapted to allow access by a screwdriver and tightening of the screws.
The present disclosure is directed to systems, method of manufacture, and packaging configurations for an antimicrobial orthopedic implant having an antimicrobial coating on the outer surface of the implant including a vaporizable antimicrobial agent in a surface area concentration on the outer surface sufficient to prevent bacterial growth on the orthopedic implant, and can additionally provide a clinically effective zone of inhibition around the orthopedic implant. In certain embodiments, a container, a reservoir of the vaporizable antimicrobial agent, and the orthopedic implant are configured to remain thermally stable in a temperature range up to 200 C.
A61B 50/30 - Récipients spécialement adaptés à l'emballage, la protection, la distribution, la collecte ou l'élimination des appareils ou des instruments chirurgicaux ou de diagnostic
