Abstract

The present invention relates to a low temperature, continuous fine grinding process referred to as the HYPAS process for producing hydrogen chloride and one or more potassium sulphate based salts such as potassium hydrogen sulphate, potassium ammonium sulphate, potassium magnesium sulphates, potassium magnesium calcium sulphates, potassium calcium sulphate, potassium sulphate and mixtures thereof.

IPC Classes  ?

• C01D 5/02 - Preparation of sulfates from alkali metal salts and sulfuric acid or bisulfatesPreparation of bisulfates
• C01D 3/04 - Chlorides
• C01B 7/01 - ChlorineHydrogen chloride
• C01B 17/96 - Methods for the preparation of sulfates in general

Abstract

B of an oxidized sulfhydryl group of a pharmacologically acceptable sulfhydryl compound in the absence of an acid. Preferably the pharmaceutically active drug is a proton pump inhibitor and the sulfhydryl compound is N-acetyl cysteine. The disulfide compounds according to the invention can be prepared either in vitro or in vivo and are stable in the acidic conditions of the stomach. Pharmaceutical compositions containing compounds of the formula (I) and a method for the treatment or prophylaxis of gastrointestinal disorders using compounds of the formula (I) are also described.

IPC Classes  ?

• A01N 43/52 - 1,3-DiazolesHydrogenated 1,3-diazoles condensed with carbocyclic rings, e.g. benzimidazoles