Abrégé

The present invention relates to a low temperature, continuous fine grinding process referred to as the HYPAS process for producing hydrogen chloride and one or more potassium sulphate based salts such as potassium hydrogen sulphate, potassium ammonium sulphate, potassium magnesium sulphates, potassium magnesium calcium sulphates, potassium calcium sulphate, potassium sulphate and mixtures thereof.

Classes IPC  ?

• C01D 5/02 - Préparation de sulfates à partir de sels de métaux alcalins et d'acide sulfurique ou de bisulfatesPréparation de bisulfates
• C01D 3/04 - Chlorures
• C01B 7/01 - ChloreAcide chlorhydrique
• C01B 17/96 - Méthodes pour la préparation des sulfates en général

Abrégé

B of an oxidized sulfhydryl group of a pharmacologically acceptable sulfhydryl compound in the absence of an acid. Preferably the pharmaceutically active drug is a proton pump inhibitor and the sulfhydryl compound is N-acetyl cysteine. The disulfide compounds according to the invention can be prepared either in vitro or in vivo and are stable in the acidic conditions of the stomach. Pharmaceutical compositions containing compounds of the formula (I) and a method for the treatment or prophylaxis of gastrointestinal disorders using compounds of the formula (I) are also described.

Classes IPC  ?

• A01N 43/52 - Diazoles-1,3Diazoles-1,3 hydrogénés condensés avec des carbocycles, p. ex. benzimidazoles