Abstract

A compound of formula (I): (I) wherein n is an integer between 0 and 10; Y is hydrogen, halide, mesylate, tosylate, ester, —SPh, —SO2Ph, hydroxyl or protected hydroxyl; with the proviso that if n=0 or 1, Y is not hydrogen. A compound of formula (I): (I) wherein n is an integer between 0 and 10; Y is hydrogen, halide, mesylate, tosylate, ester, —SPh, —SO2Ph, hydroxyl or protected hydroxyl; with the proviso that if n=0 or 1, Y is not hydrogen.

IPC Classes  ?

• C07C 46/00 - Preparation of quinones
• C07C 50/22 - Quinones the quinoid structure being part of a condensed ring system containing four or more rings

Goods & Services

vitamins for the food industry; vitamins for manufacturing use; vitamins for the food and beverages industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; vitamins for use in the manufacture of food and beverages, all of the aforementioned containing vitamin K2 vitamins; vitamins for the animal feed industry; vitamin supplements; vitamins and dietary food supplements for animals; vitamins and vitamin preparations; food supplements; dietary food supplements; health food supplements; nutritional supplements, all of the aforementioned containing vitamin K2 milk; dairy-based beverages; non-dairy milk substitutes; yogurt; yogurt-based beverages, all of the aforementioned containing vitamin K2 sports drinks; flavored waters; fruit-based beverages; drinking water with vitamins; non-alcoholic beverages, namely, carbonated beverages; sports drinks enhanced with vitamins; energy drinks enhanced with vitamins; energy drinks, all of the aforementioned containing vitamin K2

Goods & Services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions in the nature of vitamins for use in the manufacture of food and beverages; all of the aforementioned containing vitamin K2 Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; mineral food supplements; vitamin and mineral preparations for nutritional purposes; linseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies, namely, natural remedy preparations for general immune health; nutritional supplements; alginate dietary supplements; wheat dietary supplements; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; linseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations, namely, animal feed supplements enriched with vitamin K2; glucose dietary supplements; casein dietary supplements; all of the aforementioned containing vitamin K2 Jellies, jams, compotes; fruit spreads; vegetable-based spreads; fish, seafood and molluscs, not live; processed fruits; processed edible fungi; processed vegetables, nuts and pulses; edible oils and fats; drinks made from dairy products, namely, dairy-based beverages; cheese substitutes; milk; milk substitutes; milk products excluding ice cream, ice milk and frozen yogurt; all of the aforementioned containing vitamin K2 Bread; bakery goods; rice; pastries, cakes, tarts and biscuits in the nature of cookies; crystallized rock sugar; cereal bars and ceral-based energy bars; coffee and coffee substitutes; tea and tea substitutes; cocoa and carob bpowder for use as a cocoa substitute; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments; all of the aforementioned containing vitamin K2 Non-alcoholic preparations for making beverages, namely, sport drinks and energy drinks; powders for the preparation of beverages, namely, sport drinks and energy drinks; powders for effervescing beverages, namely sport drinks and energy drinks; syrups for making beverages, namely sport drinks and energy drinks; mineral and aerated waters; fruit juice beverages; soft drinks; non-alcoholic beverages, namely sports drinks enhanced with vitamins, energy drinks enhanced with vitamins, drinking water with vitamins; drinking water with vitamins; nutritionally fortified water other than for medical purposes, namely, water fortified with vitamin K2; all of the aforementioned goods containing vitamin K2

Abstract

A composition comprising (I) vitamin K2 or prodrug thereof; (II) vitamin D wherein the weight ratio of vitamin K2 or prodrug thereof to vitamin D is at least 44:1.

IPC Classes  ?

• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61P 3/02 - Nutrients, e.g. vitamins, minerals
• A23L 33/15 - Vitamins
• A61K 31/592 - 9,10-Secoergostane derivatives, e.g. ergocalciferol, vitamin D2
• A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
• A61P 37/04 - Immunostimulants
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

A composition comprising (I) vitamin K2 or prodrug thereof; (II) vitamin D; (III) a xanthophyll; and (IV) eicosapentaenoic acid ('EPA') and/or docosahexaenoic acid ('DHA'), or salt(s) thereof.

IPC Classes  ?

• A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
• A61K 31/07 - Retinol compounds, e.g. vitamin A
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 3/02 - Nutrients, e.g. vitamins, minerals
• A23L 33/15 - Vitamins

Goods & Services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; sanitary preparations and articles; mineral food supplements; vitamin and mineral preparations; dietetic preparations adapted for medical use; linseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies; nutritional supplements; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; linseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations; glucose dietary supplements; medicinal healthcare preparations; casein dietary supplements. Meat and meat products; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats; drinks made from dairy products; cheese substitutes; milk; milk substitutes; milk products. Bread; bakery goods; rice; pastries, cakes, tarts and biscuits (cookies); sugars, natural sweeteners, sweet coatings and fillings, bee products; crystallized rock sugar; cereal bars and energy bars; processed grains, starches, and goods made thereof, baking preparations and yeasts; coffee, teas and cocoa and substitutes therefor; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments. Non-alcoholic preparations for making beverages; powders for the preparation of beverages; powders for effervescing beverages; syrups and other non-alcoholic preparations for making beverages; syrups for making beverages; mineral and aerated waters; fruit juice beverages; soft drinks; non-alcoholic beverages; drinking water with vitamins; nutritionally fortified water.

Abstract

A compound of formula (I): (I) wherein n is an integer between 0 and 10; Y is hydrogen, halide, mesylate, tosylate, ester, -SPh, -SO2Ph, hydroxyl or protected hydroxyl; with the proviso that if n = 0 or 1, Y is not hydrogen.

IPC Classes  ?

• C07C 45/67 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by isomerisationPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by change of size of the carbon skeleton
• C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
• C07C 45/68 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by isomerisationPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by change of size of the carbon skeleton by increase in the number of carbon atoms
• C07C 50/22 - Quinones the quinoid structure being part of a condensed ring system containing four or more rings
• C07C 17/16 - Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
• C07C 21/215 - Halogenated polyenes with more than two carbon-to-carbon double bonds

Goods & Services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages; vitamins for use in the manufacture of foodstuffs and fodder for animals; additives (chemical -) for use in the preparation of animal foodstuffs.

Goods & Services

(1) Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. (2) Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; sanitary preparations and articles; mineral food supplements; vitamin and mineral preparations; dietetic preparations adapted for medical use; linseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies; nutritional supplements; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; linseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations; glucose dietary supplements; medicinal healthcare preparations; casein dietary supplements. (3) Meat and meat products; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats; drinks made from dairy products; cheese substitutes; milk; milk substitutes; milk products. (4) Bread; bakery goods; rice; pastries, cakes, tarts and biscuits (cookies); sugars, natural sweeteners, sweet coatings and fillings, bee products; crystallized rock sugar; cereal bars and energy bars; processed grains, starches, and goods made thereof, baking preparations and yeasts; coffee, teas and cocoa and substitutes therefor; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments. (5) Non-alcoholic preparations for making beverages; powders for the preparation of beverages; powders for effervescing beverages; syrups and other non-alcoholic preparations for making beverages; syrups for making beverages; mineral and aerated waters; fruit juice beverages; soft drinks; non-alcoholic beverages; drinking water with vitamins; nutritionally fortified water.

Goods & Services

(1) Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; Chemical and organic compositions, namely vitamins, for use in the manufacture of food and beverages; vitamins for use in the manufacture of foodstuffs and fodder for animals; chemical additives for use in the preparation of animal foodstuffs, namely, vitamins

Goods & Services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic chemical compositions for use in the manufacture of food and beverages; vitamins for use in the manufacture of foodstuffs and fodder for animals; chemical additives for use in the preparation of animal foodstuffs

Goods & Services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages.; vitamins for use in the manufacture of foodstuffs and fodder for animals; Additives (Chemical -) for use in the preparation of animal foodstuffs. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Linseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Linseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements.. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats; Drinks made from dairy products; Cheese substitutes; Milk; Milk substitutes; Milk products.. Foodstuffs and fodder for animals; Animal foodstuffs.. Non-alcoholic preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit juice beverages; Soft drinks; Non-alcoholic beverages..

Goods & Services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages; Vitamins for use in the manufacture of foodstuffs and fodder for animals; Additives (Chemical -) for use in the preparation of animal foodstuffs.

Goods & Services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages.. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Linseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Linseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements.. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats; Drinks made from dairy products; Cheese substitutes; Milk; Milk substitutes; Milk products.. Foodstuffs and fodder for animals; Animal foodstuffs.. Non-alcoholic preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit juice beverages; Soft drinks; Non-alcoholic beverages..

Goods & Services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Linseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Linseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats; Drinks made from dairy products; Cheese substitutes; Milk; Milk substitutes; Milk products. Foodstuffs and fodder for animals; Animal foodstuffs. Non-alcoholic preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit juice beverages; Soft drinks; Non-alcoholic beverages.

Goods & Services

(1) Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. (2) Mineral dietary supplements for humans; dietary supplements for humans for general health and well being; food supplements consisting of amino acids; anti-inflammatories; antivirals; antibacterials; antibiotics; sanitary preparations and articles for medical purposes for the treatment of skin disease, immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; mineral food supplements; vitamin and mineral preparations; dietetic preparations consisting of vitamins, minerals and trace elements adapted for medical use; flaxseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies for the treatment of skin disease, immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; nutritional supplements for general health and well being; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances for the treatment of hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, namely, Alzheimer's, Huntington's Disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; flaxseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations for the treatment of skin disease, , immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; soy protein dietary supplements; vitamin food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti- oxidant pills; protein dietary supplements; vitamin and mineral dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement for general health and well being; pollen dietary supplements; nutritional supplements made of starch for general health and well being; veterinary preparations, namely, animal feed supplements enriched with vitamins; glucose dietary supplements; medicinal healthcare preparations for the treatment of skin disease, immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; casein dietary supplements. (3) Meat and prepared meat; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; snack mix consisting primarily of processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats.

Goods & Services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions, namely vitamins, all for use in the manufacture of food and beverages; all the foregoing containing vitamins K2 and MK7 Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; mineral food supplements; vitamin and mineral preparations for nutritional purposes; dietetic preparations adapted for medical use; flaxseed oil dietary supplements; propolis dietary supplements; natural remedy preparations for general immune health; nutritional supplements; alginate dietary supplements; wheat dietary supplements; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; flaxseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations, namely vitamins and nutritional supplements; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; glucose dietary supplements; casein dietary supplements; all the foregoing containing vitamins K2 and MK7 Jellies, jams, compotes; fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats; all the foregoing containing vitamins K2 and MK7

Goods & Services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; sanitary preparations and articles; mineral food supplements; vitamin and mineral preparations; dietetic preparations adapted for medical use; flaxseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies; nutritional supplements; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; flaxseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations; glucose dietary supplements; medicinal healthcare preparations; casein dietary supplements. Meat and meat products; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats. Bread; bakery goods; rice; pastries, cakes, tarts and biscuits (cookies); sugars, natural sweeteners, sweet coatings and fillings, bee products; candy; cereal bars and energy bars; processed grains, starches, and goods made thereof, baking preparations and yeasts; coffee, teas and cocoa and substitutes therefor; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments. Preparations for making beverages; powders for the preparation of beverages; powders for effervescing beverages; syrups and other non-alcoholic preparations for making beverages; syrups for making beverages; mineral and aerated waters; fruit beverages and fruit juices; non-alcoholic beverages.

Goods & Services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Flaxseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Flaxseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement.; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats. Bread; Bakery goods; rice; Pastries, cakes, tarts and biscuits (cookies); Sugars, natural sweeteners, sweet coatings and fillings, bee products; Candy; Cereal bars and energy bars; Processed grains, starches, and goods made thereof, baking preparations and yeasts; Coffee, teas and cocoa and substitutes therefor; Ice, ice creams, frozen yogurts and sorbets; Salts, seasonings, flavourings and condiments. preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit beverages and fruit juices; Non-alcoholic beverages.

Goods & Services

Pharmaceutical preparations; chemical compounds for medical or pharmaceutical purposes; healthcare preparations; dietetic preparations adapted for medical use; food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; powders for isotonic beverages; powders and tablets for effervescing beverages.

Goods & Services

pharmaceutical preparations enriched with Vitamin K2 or Provitamin K2 for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; chemical compounds for medical or pharmaceutical purposes enriched with Vitamin K2 or Provitamin K2 for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; health care preparations enriched with Vitamin K2 or Provitamin K2 for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; dietetic preparations enriched with Vitamin K2 or Provitamin K2 adapted for medical use for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; food supplements enriched with Vitamin K2 or Provitamin K2 not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; vitamin preparations enriched with Vitamin K2 or Provitamin K2 in the form of granulates, powders, emulations, dragees, capsules, juices, sweetmeats, drops; dietary supplements enriched with Vitamin K2 or Provitamin K2, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; dietary supplements enriched with Vitamin K2 or Provitamin K2, not for medical purposes, based on carbohydrates and/or soya products with added vitamins dietetic foodstuffs, enriched with Vitamin K2 or Provitamin K2 namely, eggs, processed meat, margarine, dairy products namely butter, milk and processed milk, dairy-based spreads, almond milk, oat milk, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29 dietetic foodstuffs, enriched with Vitamin K2 or Provitamin K2 namely, breakfast cereals, chocolate-based spreads, soft gummy candies, sweets not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30 Powdered fruit-based beverages enriched with Vitamin K2 or Provitamin K2; powders for isotonic sports beverages enriched with Vitamin K2 or Provitamin K2; powders and tablets for fruit-based effervescing beverages enriched with Vitamin K2 or Provitamin K2

Goods & Services

(1) Biochemical preparations for medical purposes; Vitamin preparations; antibacterial pharmaceuticals; pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroenterological diseases and disorders; pharmaceutical and veterinary preparations for the treatment of hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, namely, Alzheimer's, Huntington's Disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; Dietary and nutraceutical preparations and substances, namely, dietary vitamin supplements for use as additives to food and drink for human and animal consumption and adapted for medical or veterinary use; veterinary preparations, namely, animal feed supplements enriched with vitamins; Nutraceutical preparations, namely, dietary supplements for humans and animals for general health and well-being; Food for babies and infants enriched with vitamins; beverages, namely baby formula, infant formula, powdered milk for babies and infants enriched with vitamins; dietary vitamin supplements for non-medical use; dietary supplements consisting of vitamins; dietary vitamin supplements in the form of granules, granulates, powders, emulsions, tablets, dragees, capsules, syrup, liquids, sweets, drops; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; vitamin supplements and dietary supplements for general health and well-being enriched with vitamins in the form of preparations based on milk and milk products, lipids, edible oils and fats, proteins, carbohydrates, cereals, soya and soya derivates, fruits and vegetables

Abstract

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted with a compound of formula (III) in the presence of a copper, nickel or palladium catalyst.

IPC Classes  ?

• C07C 46/02 - Preparation of quinones by oxidation giving rise to quinoid structures
• C07C 41/18 - Preparation of ethers by reactions not forming ether-oxygen bonds
• C07C 41/22 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogenPreparation of ethers by reactions not forming ether-oxygen bonds by substitution of halogen atoms by other halogen atoms
• C07C 41/26 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
• C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
• C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
• C07C 17/16 - Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
• C07C 43/215 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
• C07C 46/04 - Preparation of quinones by oxidation giving rise to quinoid structures of unsubstituted ring carbon atoms in six-membered aromatic rings
• C07C 21/215 - Halogenated polyenes with more than two carbon-to-carbon double bonds

Abstract

A composition comprising vitamin K2 or a provitamin thereof for use in the transformation of white adipose tissue to brown adipose tissue, especially to beige adipose tissue.

IPC Classes  ?

• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin

Abstract

The disclosure relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma. The disclosure also relates to methods of treating conditions using prodrugs of vitamin K2.

IPC Classes  ?

• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• C07C 69/78 - Benzoic acid esters
• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
• C07C 69/34 - Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
• C07C 69/017 - Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
• C07F 9/09 - Esters of phosphoric acids
• C07C 69/16 - Acetic acid esters of dihydroxylic compounds
• C07C 69/28 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
• C07C 69/40 - Succinic acid esters
• C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
• C07C 271/22 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• A61K 31/325 - Carbamic acidsThiocarbamic acidsAnhydrides or salts thereof

Goods & Services

Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Pamphlets; Printed promotional material. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Goods & Services

Pharmaceuticals; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Pamphlets; Printed promotional material. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Goods & Services

Pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression; pharmaceutical and veterinary preparations for the treatment of muscoskeletal diseases and disorders, cardiological and vascular diseases and disorders; pharmaceutical and veterinary preparations for the treatment of pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroneterological diseases and disorders, hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; antibacterial pharmaceuticals; dietetic food and substances adapted for medical or veterinary use; dietary supplements for humans and animals; dietetic sugars enriched with vitamins for medical use; food for babies enriched with vitamins; veterinary preparations, namely, animal feed supplements enriched with vitamins; dietary vitamin supplements for non-medical use; dietary vitamin supplements for non-medical use including minerals, amino adds; dietary vitamin supplements in the form of granulates, powders, emulsions, tablets, capsules, syrup, liquids, sweets; dietary vitamin supplements in the form of preparations based on milk and milk products, edible oils and fats, cereals, fruits, vegetables; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; Dietary supplements not for medical use based on proteins and/or lipids with addition of vitamins; Dietary supplements not for medical use based on carbohydrates and/or soja derivates with addition of vitamins; flour and preparations made from cereals enriched with vitamins. Butter and margarines enriched with vitamins; milk and milk products enriched with vitamins; edible oils and fats enriched with vitamins. Bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins. Mineral and aerated waters, non-alcoholic beverages; isotonic drinks enriched with vitamins, fruit beverages and fruit juices; syrups, powders, effervescent tablets and other preparations for making beverages.

Goods & Services

Pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression; pharmaceutical and veterinary preparations for the treatment of muscoskeletal diseases and disorders, cardiological and vascular diseases and disorders; pharmaceutical and veterinary preparations for the treatment of pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroneterological diseases and disorders, hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; antibacterial pharmaceuticals; dietetic food and substances adapted for medical or veterinary use; dietary supplements for humans and animals; dietetic sugars enriched with vitamins for medical use; food for babies enriched with vitamins; veterinary preparations, namely, animal feed supplements enriched with vitamins; dietary vitamin supplements for non-medical use; dietary vitamin supplements for non-medical use including minerals, amino adds; dietary vitamin supplements in the form of granulates, powders, emulsions, tablets, capsules, syrup, liquids, sweets; dietary vitamin supplements in the form of preparations based on milk and milk products, edible oils and fats, cereals, fruits, vegetables; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; Dietary supplements not for medical use based on proteins and/or lipids with addition of vitamins; Dietary supplements not for medical use based on carbohydrates and/or soja derivates with addition of vitamins; flour and preparations made from cereals enriched with vitamins. Butter and margarines enriched with vitamins; milk and milk products enriched with vitamins; edible oils and fats enriched with vitamins. Bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins. Bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins.

Goods & Services

Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins; Nutritional supplements; Mineral food supplements; Soy protein dietary supplements; Flaxseed dietary supplements; Flaxseed oil dietary supplements; Propolis dietary supplements; Yeast dietary supplements; Casein dietary supplements; Albumin dietary supplements; Alginate dietary supplements; Wheat germ dietary supplements; Anti-oxidant food supplements; Protein dietary supplements; Wheat dietary supplements; Zinc dietary supplements; Food supplements consisting of amino acids; Food supplements consisting of trace elements; Dietary supplements consisting of vitamins; Pollen dietary supplements; Enzyme dietary supplements; Lecithin dietary supplements; Dietary supplements for humans; Royal jelly dietary supplements; Glucose dietary supplements; Mineral dietary supplements for humans; Food supplements; Nutritional supplement meal replacement bars for boosting energy; Nutritional supplements; Dietary supplements and dietetic preparations; Dietary supplements for controlling cholesterol; Nutritional supplements made of starch adapted for medical use; Nutraceuticals for use as a dietary supplement; Glucose for use as an additive to foods for medical purposes; Ground flaxseed fiber for use as a dietary supplement. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not adapted for medical use, based on carbohydrates and/or soya products, with added vitamins, included in class 30; Wheat germ [other than a dietary supplement]. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Goods & Services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins; Nutritional supplements; Mineral food supplements; Soy protein dietary supplements; Flaxseed dietary supplements; Flaxseed oil dietary supplements; Propolis dietary supplements; Yeast dietary supplements; Casein dietary supplements; Albumin dietary supplements; Alginate dietary supplements; Wheat germ dietary supplements; Anti-oxidant food supplements; Protein dietary supplements; Wheat dietary supplements; Zinc dietary supplements; Food supplements consisting of amino acids; Food supplements consisting of trace elements; Dietary supplements consisting of vitamins; Pollen dietary supplements; Enzyme dietary supplements; Lecithin dietary supplements; Dietary supplements for humans; Royal jelly dietary supplements; Glucose dietary supplements; Mineral dietary supplements for humans; Food supplements; Nutritional supplement meal replacement bars for boosting energy; Nutritional supplements; Dietary supplements and dietetic preparations; Dietary supplements for controlling cholesterol; Nutritional supplements made of starch adapted for medical use; Nutraceuticals for use as a dietary supplement; Glucose for use as an additive to foods for medical purposes; Ground flaxseed fiber for use as a dietary supplement. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not adapted for medical use, based on carbohydrates and/or soya products, with added vitamins, included in class 30; Wheat germ [other than a dietary supplement]. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Goods & Services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Goods & Services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Goods & Services

Pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression, muscoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroneterological diseases and disorders, hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; antibacterial pharmaceuticals; dietetic food and substances adapted for medical or veterinary use; dietary supplements for humans and animals; dietetic sugars enriched with vitamins for medical use; food for babies enriched with vitamins; veterinary preparations, namely, animal feed supplements enriched with vitamins; dietary vitamin supplements for non-medical use; dietary vitamin supplements for non-medical use including minerals, amino adds; dietary vitamin supplements in the form of granulates, powders, emulsions, tablets, capsules, syrup, liquids, sweets; dietary vitamin supplements in the form of preparations based on milk and milk products, edible oils and fats, cereals, fruits, vegetables; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; Dietary supplements not for medical use based on proteins and/or lipids with addition of vitamins; dietary supplements in form of enriched milk, butter and margarins;  Dietary supplements not for medical use based on carbohydrates and/or soja derivates with addition of vitamins. Milk and milk products enriched with vitamins; edible oils and fats enriched with vitamins. Flour and preparations made from cereals enriched with vitamins; bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins.

Abstract

This application relates to new formulations of vitamin K1 and K2 provitamins. These formulations can be used as nutraceuticals, e.g. for the fortification of foods or simply in supplements or can be used in pharmaceuticals for the treatment of a variety of conditions known to benefit from the administration of vitamin K1 and K2.

IPC Classes  ?

• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
• A61K 31/223 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-amino acids
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• A61K 31/05 - Phenols
• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 33/06 - Aluminium, calcium or magnesiumCompounds thereof

Abstract

The invention relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma.

IPC Classes  ?

• C07C 69/16 - Acetic acid esters of dihydroxylic compounds
• C07C 69/28 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
• C07C 69/40 - Succinic acid esters
• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
• C07C 69/78 - Benzoic acid esters
• C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
• C07F 9/09 - Esters of phosphoric acids
• C07C 69/017 - Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
• C07C 69/34 - Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
• C07C 271/22 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Goods & Services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Goods & Services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Abstract

The invention relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma.

IPC Classes  ?

• C07C 39/225 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic part, with unsaturation outside the rings with at least one hydroxy group on a condensed ring system
• C07C 39/24 - Halogenated derivatives
• A61K 31/05 - Phenols
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 19/00 - Drugs for skeletal disorders

Goods & Services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings, material for stopping teeth, dental wax, disinfectants; preparations for destroying vermin; fungicides; herbicides. Meat, fish, poultry and game; meat extracts; preserved, dried, frozen and boiled fruits and vegetables, jellies, jams, compotes, eggs, milk and dairy products, edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, coffee substitute; flour and food articles from cereals, bread, pastries and confectionery, confections, edible ice; honey, syrup; yeast, baking powder; salt, mustard; vinegar, sauces, spices, ice. Beer; mineral water, carbonated water and other non-alcoholic drinks; fruit drinks and fruit juices; syrups and other preparations for making beverages.

Goods & Services

[ Pharmaceutical and veterinary preparations, namely, antibacterial pharmaceuticals, pharmaceutical preparations for treating skin disease ] pharmaceutical preparations for treating cardiovascular disease; pharmaceutical preparations for treating osteoporosis [ sanitary preparations for medical purposes; dietetic substances adapted for medical use, namely, dietetic sugars enriched with Vitamin K2; food for babies enriched with Vitamin K2; veterinary preparations, namely, animal feed supplements enriched with Vitamin K2 ] [ Meat, fish, poultry and game; meat extracts; preserved, dried, frozen and boiled fruits and vegetables, jellies, jams, compotes; eggs, milk and dairy products, excluding ice cream, ice milk and frozen yogurt; edible oils and fats ] [ Coffee, tea, cocoa, sugar, rice, tapioca, coffee substitute; flour; food articles from cereals, namely, ready to eat breakfast cereal; bread; pastries; confectionery, namely, fondants; confections, namely, frozen confections; edible ice; honey; syrup, namely, flavoring syrup; yeast, baking powder; salt, mustard; vinegar, sauces, spices, ice ] [ Beer; mineral water enriched with Vitamin K2, carbonated water enriched with Vitamin K2; non-alcoholic drinks, namely, soft drinks enriched with Vitamin K2 * sports drinks * ; fruit drinks and fruit juices enriched with Vitamin K2; syrups and other preparations enriched with Vitamin K2, for making soft drinks ]

Abstract

A new process for making polyprenols is described as well as the use of these building blocks in the synthesis of Vitamin K2. The process involves reaction of a compound of formula (X) with a compound of formula (XI) in the presence of a base so as to form a compound of formula (XII) and conversion of that compound into a compound of formula (XIII).

IPC Classes  ?

• C07C 29/147 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
• C07C 46/02 - Preparation of quinones by oxidation giving rise to quinoid structures
• C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
• C07C 317/18 - SulfonesSulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
• C07C 323/14 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
• C07C 33/02 - Acyclic alcohols with carbon-to-carbon double bonds

Abstract

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.

IPC Classes  ?

• C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
• C07C 41/18 - Preparation of ethers by reactions not forming ether-oxygen bonds
• C07C 41/22 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogenPreparation of ethers by reactions not forming ether-oxygen bonds by substitution of halogen atoms by other halogen atoms
• C07C 41/26 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
• C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
• C07C 46/02 - Preparation of quinones by oxidation giving rise to quinoid structures
• C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• C07C 17/16 - Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups

Abstract

A compound of formula (I) in solid form, preferably crystalline form.

IPC Classes  ?

• C07C 46/02 - Preparation of quinones by oxidation giving rise to quinoid structures
• C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
• C07C 41/18 - Preparation of ethers by reactions not forming ether-oxygen bonds
• C07C 41/26 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
• C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
• C07C 43/215 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
• C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• C07C 317/18 - SulfonesSulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton

Abstract

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.

IPC Classes  ?

• C07C 46/02 - Preparation of quinones by oxidation giving rise to quinoid structures
• C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
• C07C 41/18 - Preparation of ethers by reactions not forming ether-oxygen bonds
• C07C 41/26 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
• C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
• C07C 43/215 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
• C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• C07C 317/18 - SulfonesSulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton