Abrégé

A compound of formula (I): (I) wherein n is an integer between 0 and 10; Y is hydrogen, halide, mesylate, tosylate, ester, —SPh, —SO2Ph, hydroxyl or protected hydroxyl; with the proviso that if n=0 or 1, Y is not hydrogen. A compound of formula (I): (I) wherein n is an integer between 0 and 10; Y is hydrogen, halide, mesylate, tosylate, ester, —SPh, —SO2Ph, hydroxyl or protected hydroxyl; with the proviso that if n=0 or 1, Y is not hydrogen.

Classes IPC  ?

• C07C 46/00 - Préparation de quinones
• C07C 50/22 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant au moins quatre cycles

Produits et services

vitamins for the food industry; vitamins for manufacturing use; vitamins for the food and beverages industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; vitamins for use in the manufacture of food and beverages, all of the aforementioned containing vitamin K2 vitamins; vitamins for the animal feed industry; vitamin supplements; vitamins and dietary food supplements for animals; vitamins and vitamin preparations; food supplements; dietary food supplements; health food supplements; nutritional supplements, all of the aforementioned containing vitamin K2 milk; dairy-based beverages; non-dairy milk substitutes; yogurt; yogurt-based beverages, all of the aforementioned containing vitamin K2 sports drinks; flavored waters; fruit-based beverages; drinking water with vitamins; non-alcoholic beverages, namely, carbonated beverages; sports drinks enhanced with vitamins; energy drinks enhanced with vitamins; energy drinks, all of the aforementioned containing vitamin K2

Produits et services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions in the nature of vitamins for use in the manufacture of food and beverages; all of the aforementioned containing vitamin K2 Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; mineral food supplements; vitamin and mineral preparations for nutritional purposes; linseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies, namely, natural remedy preparations for general immune health; nutritional supplements; alginate dietary supplements; wheat dietary supplements; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; linseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations, namely, animal feed supplements enriched with vitamin K2; glucose dietary supplements; casein dietary supplements; all of the aforementioned containing vitamin K2 Jellies, jams, compotes; fruit spreads; vegetable-based spreads; fish, seafood and molluscs, not live; processed fruits; processed edible fungi; processed vegetables, nuts and pulses; edible oils and fats; drinks made from dairy products, namely, dairy-based beverages; cheese substitutes; milk; milk substitutes; milk products excluding ice cream, ice milk and frozen yogurt; all of the aforementioned containing vitamin K2 Bread; bakery goods; rice; pastries, cakes, tarts and biscuits in the nature of cookies; crystallized rock sugar; cereal bars and ceral-based energy bars; coffee and coffee substitutes; tea and tea substitutes; cocoa and carob bpowder for use as a cocoa substitute; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments; all of the aforementioned containing vitamin K2 Non-alcoholic preparations for making beverages, namely, sport drinks and energy drinks; powders for the preparation of beverages, namely, sport drinks and energy drinks; powders for effervescing beverages, namely sport drinks and energy drinks; syrups for making beverages, namely sport drinks and energy drinks; mineral and aerated waters; fruit juice beverages; soft drinks; non-alcoholic beverages, namely sports drinks enhanced with vitamins, energy drinks enhanced with vitamins, drinking water with vitamins; drinking water with vitamins; nutritionally fortified water other than for medical purposes, namely, water fortified with vitamin K2; all of the aforementioned goods containing vitamin K2

Abrégé

A composition comprising (I) vitamin K2 or prodrug thereof; (II) vitamin D wherein the weight ratio of vitamin K2 or prodrug thereof to vitamin D is at least 44:1.

Classes IPC  ?

• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
• A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
• A23L 33/15 - Vitamines
• A61K 31/592 - Dérivés du 9,10-séco-ergostane, p. ex. ergocalciférol, vitamine D2
• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3
• A61P 37/04 - Immunostimulants
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif

Abrégé

A composition comprising (I) vitamin K2 or prodrug thereof; (II) vitamin D; (III) a xanthophyll; and (IV) eicosapentaenoic acid ('EPA') and/or docosahexaenoic acid ('DHA'), or salt(s) thereof.

Classes IPC  ?

• A61K 31/045 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates
• A61K 31/07 - Composés du rétinol, p. ex. vitamine A
• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
• A61K 31/202 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant au moins trois doubles liaisons, p. ex. acide linolénique
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
• A23L 33/15 - Vitamines

Produits et services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; sanitary preparations and articles; mineral food supplements; vitamin and mineral preparations; dietetic preparations adapted for medical use; linseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies; nutritional supplements; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; linseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations; glucose dietary supplements; medicinal healthcare preparations; casein dietary supplements. Meat and meat products; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats; drinks made from dairy products; cheese substitutes; milk; milk substitutes; milk products. Bread; bakery goods; rice; pastries, cakes, tarts and biscuits (cookies); sugars, natural sweeteners, sweet coatings and fillings, bee products; crystallized rock sugar; cereal bars and energy bars; processed grains, starches, and goods made thereof, baking preparations and yeasts; coffee, teas and cocoa and substitutes therefor; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments. Non-alcoholic preparations for making beverages; powders for the preparation of beverages; powders for effervescing beverages; syrups and other non-alcoholic preparations for making beverages; syrups for making beverages; mineral and aerated waters; fruit juice beverages; soft drinks; non-alcoholic beverages; drinking water with vitamins; nutritionally fortified water.

Abrégé

A compound of formula (I): (I) wherein n is an integer between 0 and 10; Y is hydrogen, halide, mesylate, tosylate, ester, -SPh, -SO2Ph, hydroxyl or protected hydroxyl; with the proviso that if n = 0 or 1, Y is not hydrogen.

Classes IPC  ?

• C07C 45/67 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par isomérisationPréparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par modification de la taille du squelette carboné
• C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
• C07C 45/68 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par isomérisationPréparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par modification de la taille du squelette carboné par augmentation du nombre d'atomes de carbone
• C07C 50/22 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant au moins quatre cycles
• C07C 17/16 - Préparation d'hydrocarbures halogénés par remplacement par des halogènes de groupes hydroxyle
• C07C 21/215 - Polyènes halogénés contenant plus de deux liaisons doubles carbone-carbone

Produits et services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages; vitamins for use in the manufacture of foodstuffs and fodder for animals; additives (chemical -) for use in the preparation of animal foodstuffs.

Produits et services

(1) Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. (2) Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; sanitary preparations and articles; mineral food supplements; vitamin and mineral preparations; dietetic preparations adapted for medical use; linseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies; nutritional supplements; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; linseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations; glucose dietary supplements; medicinal healthcare preparations; casein dietary supplements. (3) Meat and meat products; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats; drinks made from dairy products; cheese substitutes; milk; milk substitutes; milk products. (4) Bread; bakery goods; rice; pastries, cakes, tarts and biscuits (cookies); sugars, natural sweeteners, sweet coatings and fillings, bee products; crystallized rock sugar; cereal bars and energy bars; processed grains, starches, and goods made thereof, baking preparations and yeasts; coffee, teas and cocoa and substitutes therefor; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments. (5) Non-alcoholic preparations for making beverages; powders for the preparation of beverages; powders for effervescing beverages; syrups and other non-alcoholic preparations for making beverages; syrups for making beverages; mineral and aerated waters; fruit juice beverages; soft drinks; non-alcoholic beverages; drinking water with vitamins; nutritionally fortified water.

Produits et services

(1) Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; Chemical and organic compositions, namely vitamins, for use in the manufacture of food and beverages; vitamins for use in the manufacture of foodstuffs and fodder for animals; chemical additives for use in the preparation of animal foodstuffs, namely, vitamins

Produits et services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic chemical compositions for use in the manufacture of food and beverages; vitamins for use in the manufacture of foodstuffs and fodder for animals; chemical additives for use in the preparation of animal foodstuffs

Produits et services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages.; vitamins for use in the manufacture of foodstuffs and fodder for animals; Additives (Chemical -) for use in the preparation of animal foodstuffs. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Linseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Linseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements.. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats; Drinks made from dairy products; Cheese substitutes; Milk; Milk substitutes; Milk products.. Foodstuffs and fodder for animals; Animal foodstuffs.. Non-alcoholic preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit juice beverages; Soft drinks; Non-alcoholic beverages..

Produits et services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages; Vitamins for use in the manufacture of foodstuffs and fodder for animals; Additives (Chemical -) for use in the preparation of animal foodstuffs.

Produits et services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages.. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Linseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Linseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements.. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats; Drinks made from dairy products; Cheese substitutes; Milk; Milk substitutes; Milk products.. Foodstuffs and fodder for animals; Animal foodstuffs.. Non-alcoholic preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit juice beverages; Soft drinks; Non-alcoholic beverages..

Produits et services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Linseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Linseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats; Drinks made from dairy products; Cheese substitutes; Milk; Milk substitutes; Milk products. Foodstuffs and fodder for animals; Animal foodstuffs. Non-alcoholic preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit juice beverages; Soft drinks; Non-alcoholic beverages.

Produits et services

(1) Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. (2) Mineral dietary supplements for humans; dietary supplements for humans for general health and well being; food supplements consisting of amino acids; anti-inflammatories; antivirals; antibacterials; antibiotics; sanitary preparations and articles for medical purposes for the treatment of skin disease, immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; mineral food supplements; vitamin and mineral preparations; dietetic preparations consisting of vitamins, minerals and trace elements adapted for medical use; flaxseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies for the treatment of skin disease, immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; nutritional supplements for general health and well being; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances for the treatment of hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, namely, Alzheimer's, Huntington's Disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; flaxseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations for the treatment of skin disease, , immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; soy protein dietary supplements; vitamin food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti- oxidant pills; protein dietary supplements; vitamin and mineral dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement for general health and well being; pollen dietary supplements; nutritional supplements made of starch for general health and well being; veterinary preparations, namely, animal feed supplements enriched with vitamins; glucose dietary supplements; medicinal healthcare preparations for the treatment of skin disease, immunology diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, hormonal diseases and disorders, gastroenterological diseases and disorders; casein dietary supplements. (3) Meat and prepared meat; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; snack mix consisting primarily of processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats.

Produits et services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions, namely vitamins, all for use in the manufacture of food and beverages; all the foregoing containing vitamins K2 and MK7 Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; mineral food supplements; vitamin and mineral preparations for nutritional purposes; dietetic preparations adapted for medical use; flaxseed oil dietary supplements; propolis dietary supplements; natural remedy preparations for general immune health; nutritional supplements; alginate dietary supplements; wheat dietary supplements; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; flaxseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations, namely vitamins and nutritional supplements; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; glucose dietary supplements; casein dietary supplements; all the foregoing containing vitamins K2 and MK7 Jellies, jams, compotes; fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats; all the foregoing containing vitamins K2 and MK7

Produits et services

Vitamins for the food industry; vitamins for use in the manufacture of pharmaceuticals; vitamins for use in the manufacture of food supplements; chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; dietary supplements for humans; food supplements consisting of amino acids; sanitary preparations and articles; mineral food supplements; vitamin and mineral preparations; dietetic preparations adapted for medical use; flaxseed oil dietary supplements; propolis dietary supplements; pharmaceuticals and natural remedies; nutritional supplements; alginate dietary supplements; wheat dietary supplements; veterinary preparations and substances; dietary supplements consisting of vitamins; dietary supplements for controlling cholesterol; flaxseed dietary supplements; royal jelly dietary supplements; glucose for use as an additive to foods for medical purposes; nutritional supplement meal replacement bars for boosting energy; zinc dietary supplements; pharmaceutical preparations; soy protein dietary supplements; food supplements; lecithin dietary supplements; yeast dietary supplements; albumin dietary supplements; protein dietary supplements; anti-oxidant food supplements; enzyme dietary supplements; dietary supplements and dietetic preparations; wheat germ dietary supplements; food supplements consisting of trace elements; ground flaxseed fiber for use as a dietary supplement; nutraceuticals for use as a dietary supplement; pollen dietary supplements; nutritional supplements made of starch adapted for medical use; veterinary preparations; glucose dietary supplements; medicinal healthcare preparations; casein dietary supplements. Meat and meat products; dairy products and dairy substitutes; jellies, jams, compotes, fruit and vegetable spreads; fish, seafood and molluscs, not live; processed fruits, fungi, vegetables, nuts and pulses; edible oils and fats. Bread; bakery goods; rice; pastries, cakes, tarts and biscuits (cookies); sugars, natural sweeteners, sweet coatings and fillings, bee products; candy; cereal bars and energy bars; processed grains, starches, and goods made thereof, baking preparations and yeasts; coffee, teas and cocoa and substitutes therefor; ice, ice creams, frozen yogurts and sorbets; salts, seasonings, flavourings and condiments. Preparations for making beverages; powders for the preparation of beverages; powders for effervescing beverages; syrups and other non-alcoholic preparations for making beverages; syrups for making beverages; mineral and aerated waters; fruit beverages and fruit juices; non-alcoholic beverages.

Produits et services

Vitamins for the food industry; Vitamins for use in the manufacture of pharmaceuticals; Vitamins for use in the manufacture of food supplements; Chemical and organic compositions for use in the manufacture of food and beverages. Mineral dietary supplements for humans; Dietary supplements for humans; Food supplements consisting of amino acids; Sanitary preparations and articles; Mineral food supplements; Vitamin and mineral preparations; Dietetic preparations adapted for medical use; Flaxseed oil dietary supplements; Propolis dietary supplements; Pharmaceuticals and natural remedies; Nutritional supplements; Alginate dietary supplements; Wheat dietary supplements; Veterinary preparations and substances; Dietary supplements consisting of vitamins; Dietary supplements for controlling cholesterol; Flaxseed dietary supplements; Royal jelly dietary supplements; Glucose for use as an additive to foods for medical purposes; Nutritional supplement meal replacement bars for boosting energy; Zinc dietary supplements; Pharmaceutical preparations; Soy protein dietary supplements; Food supplements; Lecithin dietary supplements; Yeast dietary supplements; Albumin dietary supplements; Protein dietary supplements; Anti-oxidant food supplements; Enzyme dietary supplements; Dietary supplements and dietetic preparations; Wheat germ dietary supplements; Food supplements consisting of trace elements; Ground flaxseed fiber for use as a dietary supplement.; Nutraceuticals for use as a dietary supplement; Pollen dietary supplements; Nutritional supplements made of starch adapted for medical use; Veterinary preparations; Glucose dietary supplements; Medicinal healthcare preparations; Casein dietary supplements. Meat and meat products; Dairy products and dairy substitutes; Jellies, jams, compotes, fruit and vegetable spreads; Fish, seafood and molluscs, not live; Processed fruits, fungi, vegetables, nuts and pulses; Edible oils and fats. Bread; Bakery goods; rice; Pastries, cakes, tarts and biscuits (cookies); Sugars, natural sweeteners, sweet coatings and fillings, bee products; Candy; Cereal bars and energy bars; Processed grains, starches, and goods made thereof, baking preparations and yeasts; Coffee, teas and cocoa and substitutes therefor; Ice, ice creams, frozen yogurts and sorbets; Salts, seasonings, flavourings and condiments. preparations for making beverages; Powders for the preparation of beverages; Powders for effervescing beverages; Syrups and other non-alcoholic preparations for making beverages; Syrups for making beverages; Mineral and aerated waters; Fruit beverages and fruit juices; Non-alcoholic beverages.

Produits et services

Pharmaceutical preparations; chemical compounds for medical or pharmaceutical purposes; healthcare preparations; dietetic preparations adapted for medical use; food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; powders for isotonic beverages; powders and tablets for effervescing beverages.

Produits et services

pharmaceutical preparations enriched with Vitamin K2 or Provitamin K2 for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; chemical compounds for medical or pharmaceutical purposes enriched with Vitamin K2 or Provitamin K2 for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; health care preparations enriched with Vitamin K2 or Provitamin K2 for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; dietetic preparations enriched with Vitamin K2 or Provitamin K2 adapted for medical use for the treatment of energy metabolism related health conditions, bone health, tooth health, cardio-vascular disease, inflammation, prostate health, cancer, digestive health; food supplements enriched with Vitamin K2 or Provitamin K2 not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; vitamin preparations enriched with Vitamin K2 or Provitamin K2 in the form of granulates, powders, emulations, dragees, capsules, juices, sweetmeats, drops; dietary supplements enriched with Vitamin K2 or Provitamin K2, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; dietary supplements enriched with Vitamin K2 or Provitamin K2, not for medical purposes, based on carbohydrates and/or soya products with added vitamins dietetic foodstuffs, enriched with Vitamin K2 or Provitamin K2 namely, eggs, processed meat, margarine, dairy products namely butter, milk and processed milk, dairy-based spreads, almond milk, oat milk, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29 dietetic foodstuffs, enriched with Vitamin K2 or Provitamin K2 namely, breakfast cereals, chocolate-based spreads, soft gummy candies, sweets not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30 Powdered fruit-based beverages enriched with Vitamin K2 or Provitamin K2; powders for isotonic sports beverages enriched with Vitamin K2 or Provitamin K2; powders and tablets for fruit-based effervescing beverages enriched with Vitamin K2 or Provitamin K2

Produits et services

(1) Biochemical preparations for medical purposes; Vitamin preparations; antibacterial pharmaceuticals; pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression, musculoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroenterological diseases and disorders; pharmaceutical and veterinary preparations for the treatment of hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, namely, Alzheimer's, Huntington's Disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; Dietary and nutraceutical preparations and substances, namely, dietary vitamin supplements for use as additives to food and drink for human and animal consumption and adapted for medical or veterinary use; veterinary preparations, namely, animal feed supplements enriched with vitamins; Nutraceutical preparations, namely, dietary supplements for humans and animals for general health and well-being; Food for babies and infants enriched with vitamins; beverages, namely baby formula, infant formula, powdered milk for babies and infants enriched with vitamins; dietary vitamin supplements for non-medical use; dietary supplements consisting of vitamins; dietary vitamin supplements in the form of granules, granulates, powders, emulsions, tablets, dragees, capsules, syrup, liquids, sweets, drops; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; vitamin supplements and dietary supplements for general health and well-being enriched with vitamins in the form of preparations based on milk and milk products, lipids, edible oils and fats, proteins, carbohydrates, cereals, soya and soya derivates, fruits and vegetables

Abrégé

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted with a compound of formula (III) in the presence of a copper, nickel or palladium catalyst.

Classes IPC  ?

• C07C 46/02 - Préparation de quinones par oxydation avec formation de structures quinoïdes
• C07C 41/18 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther
• C07C 41/22 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction d'atomes d'halogènePréparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par substitution d'atomes d'halogène par des atomes d'autres halogènes
• C07C 41/26 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction de groupes hydroxyle ou O-métal
• C07C 41/30 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par augmentation du nombre d'atomes de carbone, p. ex. par oligomérisation
• C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
• C07C 315/04 - Préparation de sulfonesPréparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde
• C07C 319/20 - Préparation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures de sulfures par des réactions n'impliquant pas la formation de groupes sulfure
• C07C 17/16 - Préparation d'hydrocarbures halogénés par remplacement par des halogènes de groupes hydroxyle
• C07C 43/215 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons avec une insaturation autre que celle des cycles aromatiques à six chaînons
• C07C 46/04 - Préparation de quinones par oxydation avec formation de structures quinoïdes d'atomes de carbone non substitués de cycles aromatiques à six chaînons
• C07C 21/215 - Polyènes halogénés contenant plus de deux liaisons doubles carbone-carbone

Abrégé

A composition comprising vitamin K2 or a provitamin thereof for use in the transformation of white adipose tissue to brown adipose tissue, especially to beige adipose tissue.

Classes IPC  ?

• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline

Abrégé

The disclosure relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma. The disclosure also relates to methods of treating conditions using prodrugs of vitamin K2.

Classes IPC  ?

• A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion
• A61K 31/222 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine avec des composés ayant des groupes aromatiques, p. ex. dipivéfrine, ibopamine
• A61K 31/235 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques ayant un noyau aromatique lié au groupe carboxyle
• C07C 69/78 - Esters d'acide benzoïque
• C07C 69/76 - Esters d'acides carboxyliques dont un groupe carboxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons
• C07C 69/34 - Esters d'acides acycliques polycarboxyliques saturés dont un groupe carboxyle estérifié est lié à un atome de carbone acyclique
• C07C 69/017 - Esters de composés hydroxylés dont le groupe hydroxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons
• C07F 9/09 - Esters des acides phosphoriques
• C07C 69/16 - Esters d'acide acétique de composés dihydroxylés
• C07C 69/28 - Esters d'acides acycliques monocarboxyliques saturés dont le groupe carboxyle est lié à un atome de carbone acyclique ou à l'hydrogène avec au moins trois atomes de carbone dans la partie acide estérifiés par des composés dihydroxylés
• C07C 69/40 - Esters d'acide succinique
• C07F 9/12 - Esters des acides phosphoriques avec des composés hydroxyarylés
• C07C 271/22 - Esters des acides carbamiques ayant des atomes d'oxygène de groupes carbamate liés à des atomes de carbone acycliques avec les atomes d'azote des groupes carbamate liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone de radicaux hydrocarbonés substitués par des groupes carboxyle
• A61K 31/325 - Acides carbamiquesAcides thiocarbamiquesLeurs anhydrides ou sels

Produits et services

Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Pamphlets; Printed promotional material. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Produits et services

Pharmaceuticals; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Pamphlets; Printed promotional material. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Produits et services

Pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression; pharmaceutical and veterinary preparations for the treatment of muscoskeletal diseases and disorders, cardiological and vascular diseases and disorders; pharmaceutical and veterinary preparations for the treatment of pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroneterological diseases and disorders, hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; antibacterial pharmaceuticals; dietetic food and substances adapted for medical or veterinary use; dietary supplements for humans and animals; dietetic sugars enriched with vitamins for medical use; food for babies enriched with vitamins; veterinary preparations, namely, animal feed supplements enriched with vitamins; dietary vitamin supplements for non-medical use; dietary vitamin supplements for non-medical use including minerals, amino adds; dietary vitamin supplements in the form of granulates, powders, emulsions, tablets, capsules, syrup, liquids, sweets; dietary vitamin supplements in the form of preparations based on milk and milk products, edible oils and fats, cereals, fruits, vegetables; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; Dietary supplements not for medical use based on proteins and/or lipids with addition of vitamins; Dietary supplements not for medical use based on carbohydrates and/or soja derivates with addition of vitamins; flour and preparations made from cereals enriched with vitamins. Butter and margarines enriched with vitamins; milk and milk products enriched with vitamins; edible oils and fats enriched with vitamins. Bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins. Mineral and aerated waters, non-alcoholic beverages; isotonic drinks enriched with vitamins, fruit beverages and fruit juices; syrups, powders, effervescent tablets and other preparations for making beverages.

Produits et services

Pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression; pharmaceutical and veterinary preparations for the treatment of muscoskeletal diseases and disorders, cardiological and vascular diseases and disorders; pharmaceutical and veterinary preparations for the treatment of pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroneterological diseases and disorders, hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; antibacterial pharmaceuticals; dietetic food and substances adapted for medical or veterinary use; dietary supplements for humans and animals; dietetic sugars enriched with vitamins for medical use; food for babies enriched with vitamins; veterinary preparations, namely, animal feed supplements enriched with vitamins; dietary vitamin supplements for non-medical use; dietary vitamin supplements for non-medical use including minerals, amino adds; dietary vitamin supplements in the form of granulates, powders, emulsions, tablets, capsules, syrup, liquids, sweets; dietary vitamin supplements in the form of preparations based on milk and milk products, edible oils and fats, cereals, fruits, vegetables; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; Dietary supplements not for medical use based on proteins and/or lipids with addition of vitamins; Dietary supplements not for medical use based on carbohydrates and/or soja derivates with addition of vitamins; flour and preparations made from cereals enriched with vitamins. Butter and margarines enriched with vitamins; milk and milk products enriched with vitamins; edible oils and fats enriched with vitamins. Bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins. Bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins.

Produits et services

Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins; Nutritional supplements; Mineral food supplements; Soy protein dietary supplements; Flaxseed dietary supplements; Flaxseed oil dietary supplements; Propolis dietary supplements; Yeast dietary supplements; Casein dietary supplements; Albumin dietary supplements; Alginate dietary supplements; Wheat germ dietary supplements; Anti-oxidant food supplements; Protein dietary supplements; Wheat dietary supplements; Zinc dietary supplements; Food supplements consisting of amino acids; Food supplements consisting of trace elements; Dietary supplements consisting of vitamins; Pollen dietary supplements; Enzyme dietary supplements; Lecithin dietary supplements; Dietary supplements for humans; Royal jelly dietary supplements; Glucose dietary supplements; Mineral dietary supplements for humans; Food supplements; Nutritional supplement meal replacement bars for boosting energy; Nutritional supplements; Dietary supplements and dietetic preparations; Dietary supplements for controlling cholesterol; Nutritional supplements made of starch adapted for medical use; Nutraceuticals for use as a dietary supplement; Glucose for use as an additive to foods for medical purposes; Ground flaxseed fiber for use as a dietary supplement. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not adapted for medical use, based on carbohydrates and/or soya products, with added vitamins, included in class 30; Wheat germ [other than a dietary supplement]. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Produits et services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins; Nutritional supplements; Mineral food supplements; Soy protein dietary supplements; Flaxseed dietary supplements; Flaxseed oil dietary supplements; Propolis dietary supplements; Yeast dietary supplements; Casein dietary supplements; Albumin dietary supplements; Alginate dietary supplements; Wheat germ dietary supplements; Anti-oxidant food supplements; Protein dietary supplements; Wheat dietary supplements; Zinc dietary supplements; Food supplements consisting of amino acids; Food supplements consisting of trace elements; Dietary supplements consisting of vitamins; Pollen dietary supplements; Enzyme dietary supplements; Lecithin dietary supplements; Dietary supplements for humans; Royal jelly dietary supplements; Glucose dietary supplements; Mineral dietary supplements for humans; Food supplements; Nutritional supplement meal replacement bars for boosting energy; Nutritional supplements; Dietary supplements and dietetic preparations; Dietary supplements for controlling cholesterol; Nutritional supplements made of starch adapted for medical use; Nutraceuticals for use as a dietary supplement; Glucose for use as an additive to foods for medical purposes; Ground flaxseed fiber for use as a dietary supplement. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not adapted for medical use, based on carbohydrates and/or soya products, with added vitamins, included in class 30; Wheat germ [other than a dietary supplement]. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Produits et services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Produits et services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Produits et services

Pharmaceutical and veterinary preparations for the treatment of skin disease, inflammatory diseases and disorders, immunology diseases and disorders, infectious diseases and disorders, diabetes, hypertension and depression, muscoskeletal diseases and disorders, cardiological and vascular diseases and disorders, pulmonary and respiratory diseases and disorders, endocrine diseases and disorders, gastroneterological diseases and disorders, hematological diseases and disorders, osteoporosis, nephrological and urological diseases, neurological diseases and disorders, ophthalmological diseases and disorders, otolaryngological diseases and disorders, rheumatological diseases and disorders; antibacterial pharmaceuticals; dietetic food and substances adapted for medical or veterinary use; dietary supplements for humans and animals; dietetic sugars enriched with vitamins for medical use; food for babies enriched with vitamins; veterinary preparations, namely, animal feed supplements enriched with vitamins; dietary vitamin supplements for non-medical use; dietary vitamin supplements for non-medical use including minerals, amino adds; dietary vitamin supplements in the form of granulates, powders, emulsions, tablets, capsules, syrup, liquids, sweets; dietary vitamin supplements in the form of preparations based on milk and milk products, edible oils and fats, cereals, fruits, vegetables; dietary supplements for humans containing vitamins in the form of energy bars, pastes, drinks, shakes, yoghurts, juices, gels, powders ready-to mix; Dietary supplements not for medical use based on proteins and/or lipids with addition of vitamins; dietary supplements in form of enriched milk, butter and margarins;  Dietary supplements not for medical use based on carbohydrates and/or soja derivates with addition of vitamins. Milk and milk products enriched with vitamins; edible oils and fats enriched with vitamins. Flour and preparations made from cereals enriched with vitamins; bread, pastry and confectionery enriched with vitamins; ices enriched with vitamins.

Abrégé

This application relates to new formulations of vitamin K1 and K2 provitamins. These formulations can be used as nutraceuticals, e.g. for the fortification of foods or simply in supplements or can be used in pharmaceuticals for the treatment of a variety of conditions known to benefit from the administration of vitamin K1 and K2.

Classes IPC  ?

• A61P 19/10 - Médicaments pour le traitement des troubles du squelette des maladies osseuses, p. ex. rachitisme, maladie de Paget de l'ostéoporose
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61K 31/222 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine avec des composés ayant des groupes aromatiques, p. ex. dipivéfrine, ibopamine
• A61K 31/223 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'alpha-amino-acides
• A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion
• A61K 31/663 - Composés ayant plusieurs groupes acide du phosphore ou leurs esters, p. ex. acide clodronique, acide pamidronique
• A61K 31/05 - Phénols
• A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
• A61K 33/06 - Aluminium, calcium ou magnésiumLeurs composés

Abrégé

The invention relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma.

Classes IPC  ?

• C07C 69/16 - Esters d'acide acétique de composés dihydroxylés
• C07C 69/28 - Esters d'acides acycliques monocarboxyliques saturés dont le groupe carboxyle est lié à un atome de carbone acyclique ou à l'hydrogène avec au moins trois atomes de carbone dans la partie acide estérifiés par des composés dihydroxylés
• C07C 69/40 - Esters d'acide succinique
• C07C 69/76 - Esters d'acides carboxyliques dont un groupe carboxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons
• C07C 69/78 - Esters d'acide benzoïque
• C07F 9/12 - Esters des acides phosphoriques avec des composés hydroxyarylés
• C07F 9/09 - Esters des acides phosphoriques
• C07C 69/017 - Esters de composés hydroxylés dont le groupe hydroxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons
• C07C 69/34 - Esters d'acides acycliques polycarboxyliques saturés dont un groupe carboxyle estérifié est lié à un atome de carbone acyclique
• C07C 271/22 - Esters des acides carbamiques ayant des atomes d'oxygène de groupes carbamate liés à des atomes de carbone acycliques avec les atomes d'azote des groupes carbamate liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone de radicaux hydrocarbonés substitués par des groupes carboxyle

Produits et services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Produits et services

Pharmaceutical preparations; Chemical compounds for medical or pharmaceutical purposes; Healthcare preparations; Dietetic preparations adapted for medical use; Food supplements not adapted for medical use with a base of vitamins, minerals, trace elements, amino acids; Vitamin preparations in the form of granules, powders, emulsions, dragees, capsules, juices, sweetmeats, drops; Dietary supplements, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids; Dietary supplements, not for medical purposes, based on carbohydrates and/or soya products with added vitamins. Dietetic foodstuffs, not for medical purposes, based on proteins and/or fats with added vitamins and/or fatty acids, included in class 29. Dietetic foodstuffs, not for medical purposes, based on carbohydrates and/or soya products with added vitamins, included in class 30. Powdered beverages; Powders for isotonic beverages; Powders and tablets for effervescing beverages.

Abrégé

The invention relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma.

Classes IPC  ?

• C07C 39/225 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques ne contenant que des cycles aromatiques à six chaînons dans la partie cyclique, avec une insaturation autre que celle des cycles au moins un groupe hydroxyle étant lié à un système cyclique condensé
• C07C 39/24 - Dérivés halogénés
• A61K 31/05 - Phénols
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 19/00 - Médicaments pour le traitement des troubles du squelette

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings, material for stopping teeth, dental wax, disinfectants; preparations for destroying vermin; fungicides; herbicides. Meat, fish, poultry and game; meat extracts; preserved, dried, frozen and boiled fruits and vegetables, jellies, jams, compotes, eggs, milk and dairy products, edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, coffee substitute; flour and food articles from cereals, bread, pastries and confectionery, confections, edible ice; honey, syrup; yeast, baking powder; salt, mustard; vinegar, sauces, spices, ice. Beer; mineral water, carbonated water and other non-alcoholic drinks; fruit drinks and fruit juices; syrups and other preparations for making beverages.

Produits et services

[ Pharmaceutical and veterinary preparations, namely, antibacterial pharmaceuticals, pharmaceutical preparations for treating skin disease ] pharmaceutical preparations for treating cardiovascular disease; pharmaceutical preparations for treating osteoporosis [ sanitary preparations for medical purposes; dietetic substances adapted for medical use, namely, dietetic sugars enriched with Vitamin K2; food for babies enriched with Vitamin K2; veterinary preparations, namely, animal feed supplements enriched with Vitamin K2 ] [ Meat, fish, poultry and game; meat extracts; preserved, dried, frozen and boiled fruits and vegetables, jellies, jams, compotes; eggs, milk and dairy products, excluding ice cream, ice milk and frozen yogurt; edible oils and fats ] [ Coffee, tea, cocoa, sugar, rice, tapioca, coffee substitute; flour; food articles from cereals, namely, ready to eat breakfast cereal; bread; pastries; confectionery, namely, fondants; confections, namely, frozen confections; edible ice; honey; syrup, namely, flavoring syrup; yeast, baking powder; salt, mustard; vinegar, sauces, spices, ice ] [ Beer; mineral water enriched with Vitamin K2, carbonated water enriched with Vitamin K2; non-alcoholic drinks, namely, soft drinks enriched with Vitamin K2 * sports drinks * ; fruit drinks and fruit juices enriched with Vitamin K2; syrups and other preparations enriched with Vitamin K2, for making soft drinks ]

Abrégé

A new process for making polyprenols is described as well as the use of these building blocks in the synthesis of Vitamin K2. The process involves reaction of a compound of formula (X) with a compound of formula (XI) in the presence of a base so as to form a compound of formula (XII) and conversion of that compound into a compound of formula (XIII).

Classes IPC  ?

• C07C 29/147 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par réduction d'un groupe fonctionnel contenant de l'oxygène de groupes contenant C=O, p. ex. —COOH d'acides carboxyliques ou de leurs dérivés
• C07C 46/02 - Préparation de quinones par oxydation avec formation de structures quinoïdes
• C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
• C07C 317/18 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné avec des groupes sulfone ou sulfoxyde liés à des atomes de carbone acycliques du squelette carboné
• C07C 323/14 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné ayant les atomes de soufre des groupes thio liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant acyclique et non saturé
• C07C 33/02 - Alcools acycliques à liaisons doubles carbone-carbone

Abrégé

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.

Classes IPC  ?

• C07C 319/20 - Préparation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures de sulfures par des réactions n'impliquant pas la formation de groupes sulfure
• C07C 41/18 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther
• C07C 41/22 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction d'atomes d'halogènePréparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par substitution d'atomes d'halogène par des atomes d'autres halogènes
• C07C 41/26 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction de groupes hydroxyle ou O-métal
• C07C 41/30 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par augmentation du nombre d'atomes de carbone, p. ex. par oligomérisation
• C07C 46/02 - Préparation de quinones par oxydation avec formation de structures quinoïdes
• C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
• C07C 315/04 - Préparation de sulfonesPréparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde
• C07C 17/16 - Préparation d'hydrocarbures halogénés par remplacement par des halogènes de groupes hydroxyle

Abrégé

A compound of formula (I) in solid form, preferably crystalline form.

Classes IPC  ?

• C07C 46/02 - Préparation de quinones par oxydation avec formation de structures quinoïdes
• C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
• C07C 41/18 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther
• C07C 41/26 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction de groupes hydroxyle ou O-métal
• C07C 41/30 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par augmentation du nombre d'atomes de carbone, p. ex. par oligomérisation
• C07C 43/215 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons avec une insaturation autre que celle des cycles aromatiques à six chaînons
• C07C 43/23 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal
• C07C 315/04 - Préparation de sulfonesPréparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde
• C07C 317/18 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné avec des groupes sulfone ou sulfoxyde liés à des atomes de carbone acycliques du squelette carboné

Abrégé

Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.

Classes IPC  ?

• C07C 46/02 - Préparation de quinones par oxydation avec formation de structures quinoïdes
• C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
• C07C 41/18 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther
• C07C 41/26 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction de groupes hydroxyle ou O-métal
• C07C 41/30 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par augmentation du nombre d'atomes de carbone, p. ex. par oligomérisation
• C07C 43/215 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons avec une insaturation autre que celle des cycles aromatiques à six chaînons
• C07C 43/23 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal
• C07C 315/04 - Préparation de sulfonesPréparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde
• C07C 317/18 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné avec des groupes sulfone ou sulfoxyde liés à des atomes de carbone acycliques du squelette carboné