Abstract

The present invention relates to a pharmaceutical composition for preventing or treating depression comprising a Lactobacillus buchneri 200793 strain, and specifically, to a composition for preventing, improving, or treating depression comprising the strain or a culture of the strain, a food composition for alleviating tension, and an animal feed additive composition for preventing or improving depression. When the composition according to the present invention is administered to a subject, sucrose preference is increased, and the expression level of TPH-1 or SERT in small intestine and large intestine tissue is increased, thereby being highly effective in alleviating depression, and thus the composition can be effectively employed for alleviating and improving various symptoms of depression.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61P 25/24 - Antidepressants
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A23K 10/18 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms

Abstract

A nonameric peptide represented by an amino acid sequence of SEQ ID NO: 1 or its enantiomeric peptide thereof according to the present invention is low in cytotoxicity and excellent in terms of proteolytic stability, antimicrobial activity, and anti-inflammatory activity and has a remarkable therapeutic effect on Gram-negative bacterial infectious diseases, sepsis, or septic shock. Accordingly, the peptides can be advantageously applied to an antimicrobial composition, an anti-inflammatory composition, and a pharmaceutical composition for prevention or treatment of Gram-negative bacterial infectious diseases, sepsis, or septic shock.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 31/04 - Antibacterial agents

Abstract

The present invention relates to a food composition using a natural extract for enhancing saltiness. More specifically, a mixing ratio of a shiitake mushroom extract, a lotus root extract and a Chinese cabbage extract, which have high saltiness perceivability, is provided and is used for preparing a double emulsion. The double emulsion prepared according to the present invention has enhanced saltiness while having a stable form, and enables the amount of oil to be reduced, and thus the present invention can be applied to the preparation of various food by using the emulsion.

IPC Classes  ?

• A23L 27/00 - SpicesFlavouring agents or condimentsArtificial sweetening agentsTable saltsDietetic salt substitutesPreparation or treatment thereof

Abstract

The present invention relates to a composition, a food composition, a cosmetic composition, and a feed composition for hair loss improvement or hair growth promotion, which contain oat young leaf and/or stem extract, and a pharmaceutical composition and a medical device for prevention or treatment of hair loss disease, which contain oat young leaf and/or stem extract. The present invention relates to a composition, a food composition, a cosmetic composition, and a feed composition for hair loss improvement or hair growth promotion, which contain oat young leaf and/or stem extract, and a pharmaceutical composition and a medical device for prevention or treatment of hair loss disease, which contain oat young leaf and/or stem extract. The oat young leaf and/or stem extract of the present invention has an excellent hair loss improving and hair growth promoting effect by promoting the proliferation of HDP cells and the expression of related genes, and can thus be utilized as medicines, medical devices, feed, foods, health functional foods, cosmetics, and the like that are effective in prevention and treatment of hair loss.

IPC Classes  ?

• A61K 36/899 - Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• A61K 8/60 - SugarsDerivatives thereof
• A61K 8/9794 - Liliopsida [monocotyledons]
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/728 - Hyaluronic acid
• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
• A61Q 7/00 - Preparations for affecting hair growth

Abstract

The present invention relates to a composition for preventing or treating hair loss, or promoting hair growth or hair nourishment, comprising, as an active ingredient, decellularized extracellular matrix derived from skin keratinocytes. By comprising, as an active ingredient, decellularized extracellular matrix derived from skin keratinocytes, the composition of the present invention significantly promotes the cell proliferation of dermal papilla cells or outer root-sheath cells and increases the expression of genes that regulate hair follicle formation and hair cycle, and thus has an excellent effect of preventing or treating hair loss or on hair growth or hair nourishment. In addition, considering that the dermal papilla cells or the outer root-sheath cells are fibroblasts and keratinocytes of the hair follicle, respectively, the composition of the present invention is expected to be effective not only in hair growth but also in skin wound repair and anti-aging. The decellularized extracellular matrix derived from skin keratinocytes, of the present invention, can be used as a functional ingredient without the risk of immune response and spread of infectious diseases, and is easy to obtain compared to extracellular vesicles or exosomes and can thus be effectively used in medicines, foods, health functional foods, feeds, cosmetics, functional cosmetics, medical devices, and the like.

IPC Classes  ?

• A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
• A61Q 7/00 - Preparations for affecting hair growth
• A61Q 5/00 - Preparations for care of the hair
• A61K 35/36 - SkinHairNailsSebaceous glandsCerumenEpidermisEpithelial cellsKeratinocytesLangerhans cellsEctodermal cells
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23K 10/20 - Animal feeding-stuffs from material of animal origin

Abstract

According to one embodiment, the provided resonant converter for an electric vehicle charger comprises: a first input side circuit including a first switching bridge, a first resonance tank and a first primary winding; a second input side circuit which is connected in parallel to the first input side circuit and which includes a second switching bridge, a second resonance tank and a second primary winding; a first output side circuit, which includes a first secondary winding for forming a first transformer together with the first primary winding, and a first rectified network; a second output side circuit which is connected in parallel to the first output side circuit, and which includes a second secondary winding for forming a second transformer together with the second primary winding, and a second rectified network; a switch for connecting the first secondary winding and the second secondary winding; and an output capacitor shared by the first output side circuit and the second output side circuit.

IPC Classes  ?

• H02M 3/00 - Conversion of DC power input into DC power output
• H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
• H02M 1/00 - Details of apparatus for conversion
• H02M 1/14 - Arrangements for reducing ripples from DC input or output
• B60L 53/22 - Constructional details or arrangements of charging converters specially adapted for charging electric vehicles

Abstract

The present invention relates to a vector system for cyclizing a target protein. The target protein can be cyclized using a recombinant expression vector according to the present invention, and the optimal conditions for said cyclization have been found. Thus, the present invention has the effect that cyclized target proteins, with a protective effect against proteolytic enzymes in the body and thus a longer half-life and improved stability, can be produced at high yield.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C07K 14/50 - Fibroblast growth factor [FGF]
• C07K 1/16 - ExtractionSeparationPurification by chromatography

Abstract

The present invention relates to a vector with increased production efficiency of FGF10 and a vector system for the production of circular FGF10. The circular fibroblast growth factor 10 (FGF10) produced using a vector encoding a fragment of FGF10 or a variant thereof demonstrates higher production efficiency compared to full-length FGF10. Specifically, a recombinant expression vector carrying an intein fragment can circularize FGF10, a fragment thereof, or a variant thereof, resulting in increased stability and half-life compared to linear proteins. The circular FGF10 produced in this manner exhibits a similar level of cell proliferation effect as linear FGF10, while significantly enhancing stability and in vivo half-life.

IPC Classes  ?

• C07K 14/50 - Fibroblast growth factor [FGF]
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion

Abstract

A method for producing a solid sodium electrolyte according to an embodiment of the present invention comprises the steps of: (a) preparing sintered bodies for beta-alumina production and powder pellets comprising a sodium source (or powder packs); (b) laminating the sintered bodies and the powder pellets comprising a sodium source (or powder packs) in alternation to prepare a laminate; and (c) heat-treating the laminate to subject the sintered bodies to gas-phase conversion, wherein the powder pellets (or powder packs) may be molded bodies of powder containing a sodium source.

IPC Classes  ?

• C04B 35/113 - Fine ceramics based on beta-aluminium oxide
• H01M 10/0562 - Solid materials
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium

Abstract

The present invention relates to a fire-extinguishing microcapsule, a method for manufacturing same, and a fire-extinguishing composition comprising same. The microcapsule includes a core containing a non-inflammable material; a first shell layer covering the core and containing inorganic nanoparticles and a water-soluble polymer; and a second shell layer covering the first shell layer and containing a polymer.

IPC Classes  ?

• A62D 1/00 - Fire-extinguishing compositionsUse of chemical substances in extinguishing fires
• B01J 13/14 - Polymerisation, crosslinking

Abstract

Disclosed are an air purification system using an oil mist and a filter, and a driving method thereof. The air purification system using the oil mist and the filter according to an embodiment of the present application may comprise a first filter module provided to be capable of providing an open state in which the first filter module is opened to allow inflow air to proceed along an input direction or an operation state in which multiple channel spaces are formed so that the inflow air passes through multiple preconfigured channel spaces while a contaminated material included in the inflow air is removed, and a spray module provided to spray an oil mist toward a surface of the first filter module.

IPC Classes  ?

• B01D 53/75 - Multi-step processes
• B01D 53/78 - Liquid phase processes with gas-liquid contact
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
• B01D 46/56 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition
• B01D 53/30 - Controlling by gas-analysis apparatus

Abstract

A scan signal driver includes: a plurality of stages configured to be driven by dividing a first frame period into a display period and a sensing period, and to sequentially output scan signals at the display period, wherein each of the plurality of stages comprises: an output control circuit; and a memory control circuit, wherein the scan driver is configured to: irregularly set a specific stage of the plurality of stages at a display period every frame; control the specific stage to: store a voltage by using the memory control circuit; and output a sensing signal by using the stored voltage at a sensing period, and the memory control circuit includes: a second memory transistor configured to electrically connect an M node with an I node; and a third memory transistor configured to electrically connect the output control circuit with the I node.

IPC Classes  ?

• G09G 3/3266 - Details of drivers for scan electrodes
• G09G 3/3233 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED] organic, e.g. using organic light-emitting diodes [OLED] using an active matrix with pixel circuitry controlling the current through the light-emitting element

Abstract

The present invention relates to a composition for the prevention and treatment of ischemic cerebrovascular diseases, including cerebral infarction, the composition comprising gintonin as an active ingredient. Gintonin according to the present invention has the effect of reducing cerebral infarction volume and can increase survival rate after the onset of cerebral infarction, and thus can be effectively used for the prevention and treatment of cerebral infarction. In addition, the neuroprotective effect and damage prevention effect of gintonin pretreatment on human brain microvascular endothelial cells (HBMECs), which are human brain-derived vascular endothelial cells, and the neuroprotective effect and therapeutic effect of gintonin post-treatment were confirmed. As a result of mechanism verification, it was found that gintonin was effective in recovering the level of reduced nitric oxide (NO), which is known to be involved in the onset and pathophysiology of cerebral infarction. Therefore, the present invention can be used to improve the prevention and treatment of ischemic cerebrovascular diseases, including cerebral infarction, and thus, medical costs can be reduced.

IPC Classes  ?

• A61K 38/14 - Peptides containing saccharide radicalsDerivatives thereof
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention relates to the use of α-2,6-sialylated immunoglobulin derived from human blood in preventing or treating dry eye syndrome or inflammatory eye diseases. Compared to IVIG, the α-2,6-sialylated immunoglobulin according to the present invention exhibits excellent therapeutic effects for dry eye syndrome even at a low dose without side effects such as fibrosis of corneal tissue, and also for intractable inflammatory eye diseases of varying severity.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 27/02 - Ophthalmic agents
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a liposome-based drug carrier for immune anticancer therapy, the carrier comprising: a liposome; an aptamer which is a target-specific ligand for cancer cells conjugated on the surface of the liposome; and an immunogenic chemo-anticancer agent and siRNA, an immunosuppressive protein inhibitor, which are co-loaded on the liposome. Accordingly, it is possible to induce a continuous tumor-specific anti-cancer immune response in cancer patients having a low response rate to a standalone immuno-oncologic agent therapy, and to reduce side effects due to non-specific drug delivery, thereby increasing the effects of immune anticancer therapy.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• A61K 9/107 - Emulsions

Abstract

RSRSRSS-DiHDPA can be effectively used in various industrial fields such as medicines, functional foods, and functional cosmetic products, and are expected to be involved in various physiological functions in animals including humans.

IPC Classes  ?

• C12P 7/6409 - Fatty acids

Abstract

A scan signal driver includes: stages to sequentially output scan signals in an active period, and to selectively output sensing signals in a vertical blank period. At least one of the stages includes: a sensing control circuit to supply a gate-on voltage to a sensing control node in response to a holding control signal during the active period, and to output the gate-on voltage of the sensing control node in response to a selectively input line select signal during the vertical blank period; an output node control circuit to supply the gate-on voltage to a pull-up node when the gate-on voltage of the sensing control node is output during the vertical blank period; and an output circuit to output a scan clock signal as a sensing signal to one of scan signal lines when the gate-on voltage is supplied to the pull-up node during the vertical blank period.

IPC Classes  ?

• G09G 3/3266 - Details of drivers for scan electrodes
• G09G 3/3233 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED] organic, e.g. using organic light-emitting diodes [OLED] using an active matrix with pixel circuitry controlling the current through the light-emitting element

Abstract

The present invention relates to: recombinant microorganisms expressing lipoxygenase; and recombinant microorganisms co-expressing lipoxygenase and Chlorella-derived decarboxylase. It was confirmed that when using lipoxygenase-based recombinant microorganisms according to the present invention as whole-cell biocatalysts, hydroxy fatty acids can be produced from unsaturated fatty acids. In addition, it was confirmed that when using the recombinant microorganisms co-expressing lipoxygenase and Chlorella-derived decarboxylase as whole-cell biocatalysts, secondary fatty alcohols can be produced from unsaturated fatty acids. Thus, the recombinant microorganisms constructed in the present invention can be used in various ways in the field of hydroxy fatty acid and secondary fatty alcohol production.

IPC Classes  ?

• C12P 7/6409 - Fatty acids
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

A method of generating a human model according to the present disclosure may include generating a plurality of feature maps from an input image, wherein the plurality of feature maps include a body center map, a part index map, a body part map and a parameter map, generating a part-attentive feature configured with feature maps for each body part based on the part index map and the body part map, readjusting the part-attentive feature based on the parameter map and generating a pose parameter based on the readjusted part-attentive feature.

IPC Classes  ?

• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06T 7/50 - Depth or shape recovery
• G06T 17/00 - 3D modelling for computer graphics
• G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestriansBody parts, e.g. hands

Abstract

A LiDAR and camera data fusion method includes generating a voxel-wise feature map based on point cloud data of a LiDAR sensor, generating a pixel-wise feature map based on image data of a camera, converting three-dimensional (3D) coordinates of point data of the voxel-wise feature map to two-dimensional (2D) coordinates, based on at least one predefined calibration parameter, and generating fused data by combining pixel data of the pixel-wise feature map and point data of the 2D coordinates.

IPC Classes  ?

• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G06V 10/40 - Extraction of image or video features
• G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestriansRecognition of traffic objects, e.g. traffic signs, traffic lights or roads

Abstract

The present invention relates to a DNA aptamer for the diagnosis of colorectal cancer and, specifically, to a composition and a kit for the diagnosis of colorectal cancer, and a colorectal cancer-specific drug delivery composition, each comprising the aptamer consisting of the nucleotide sequences of SEQ ID NOS: 4 to 35. Exhibiting high affinity and specificity for colorectal cancer cell-derived small extracellular vesicles (sEV), the aptamer of the present invention can be used for the specific and accurate diagnosis of colorectal cancer. With the strong binding with specific protein biomarkers present on the sEV membrane, the DNA aptamer suppresses the metastatic potential of cancer through sEV and is expected to find applications in the treatment of colorectal cancer.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a water electrolysis catalyst and a preparation method therefor. The water electrolysis catalyst according to the present invention has excellent oxygen evolution reaction (OER) activity and exhibits, even if an OER is carried out for a long time at a high current, excellent durability and stability, and thus can be used as an OER catalyst using fresh water and, in the future, using seawater.

IPC Classes  ?

• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 37/10 - Heat treatment in the presence of water, e.g. steam
• B01J 37/02 - Impregnation, coating or precipitation
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• B01J 37/30 - Ion-exchange
• C25B 11/085 - Organic compound

Abstract

The present invention relates to a biomarker for early diagnosis of kidney diseases, and use thereof. A composition, a kit and a method, according to one embodiment, enable kidney diseases or the risk of kidney diseases to be diagnosed at an early stage with higher accuracy, sensitivity and specificity. Particularly, the present invention enables classification into a normal group, a risk group (a stage having inherent risk factors), chronic kidney disease stage 1 (IRIS stage 1) or chronic kidney disease stages 2 to 4 (IRIS stages 2 to 4) with a sensitivity of 90% or higher and a specificity of 95% or higher on the basis of guidelines for staging chronic kidney disease (CKD) of the International Renal Interest Society (IRIS).

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

An object-based image encoding/decoding method and device of the present disclosure may include an image partition step which partitions an image to obtain a first object region, a region scaling step which scales the first object region based on a scaling factor of the first object region to obtain a second objection region, a region merging step which merges the second object region with at least one of an object region different from the second object region or a non-object region to obtain a merged image, and an image reconstruction step which reconstructs the merged image.

IPC Classes  ?

• H04N 19/119 - Adaptive subdivision aspects e.g. subdivision of a picture into rectangular or non-rectangular coding blocks
• H04N 19/124 - Quantisation
• H04N 19/172 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being an image region, e.g. an object the region being a picture, frame or field
• H04N 19/184 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being bits, e.g. of the compressed video stream

Abstract

An image encoding/decoding method, device and recording medium based sed on multiple compression levels disclosure may include extracting a region of interest for machine vision from an input image, determining a compression level of the region of interest, and encoding the compression level of the region of interest.

IPC Classes  ?

• G06T 9/00 - Image coding
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]

Abstract

The present invention relates to a urea oxidation reaction (UOR) catalyst and a preparation method therefor, the catalyst comprising: a nickel-copper metal-organic framework; and a nickel hydroxide deposited on the nickel-copper metal-organic framework through electrodeposition. Therefore, the present invention can exhibit excellent catalyst activity in a urea oxidation reaction while being thin and having a high surface area.

IPC Classes  ?

• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 23/755 - Nickel
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B01J 37/04 - Mixing
• B01J 37/08 - Heat treatment
• C25B 3/09 - Nitrogen containing compounds
• C25B 3/23 - Oxidation

Abstract

Proposed are a method of preparing a metal nanostructure, which includes (a) preparing a first metal template whose surface is coated with a polymeric micelle containing an amphiphilic polymer and (b) causing the first metal template to react with a second metal ion through a galvanic replacement reaction, and a metal nanostructure prepared thereby. The amphiphilic polymer is used as a capping agent during the replacement reaction so that the micellar polymer is adsorbed onto the template, thereby selectively allowing the replacement reaction. Thus, unlike in existing technologies in which nanostructures having limited forms are prepared, nanostructures having a new two-dimensional structure, including nanostructures having a plurality of pores formed between nanoparticles, can be prepared. Additionally, a mixing ratio of two types of solvents that differ in polarity index is adjustable to control the size of the polymeric micelle, thereby changing the structural characteristics of a finally prepared metal nanostructure.

IPC Classes  ?

• B22F 1/145 - Chemical treatment, e.g. passivation or decarburisation
• B22F 1/054 - Nanosized particles
• B22F 1/102 - Metallic powder coated with organic material
• C25B 11/061 - Metal or alloy

Abstract

The present invention relates to an organic semiconductor compound with high transmittance in the visible light spectrum and a use thereof.

IPC Classes  ?

• C07D 333/28 - Halogen atoms
• C07D 277/32 - Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 307/56 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 345/00 - Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
• H10K 85/60 - Organic compounds having low molecular weight
• H10K 30/20 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising organic-organic junctions, e.g. donor-acceptor junctions

Abstract

A road surface recognition method may include extracting first point cloud data in a front road surface region of a vehicle from point cloud data generated by LiDAR of the vehicle, generating a point cloud map by use of a local map and the first point cloud data, determining a predicted driving route of the vehicle based on motion-related data of the vehicle; and generating a road surface height profile of the predicted driving route based on the point cloud map and the predicted driving route.

IPC Classes  ?

• B60W 40/06 - Road conditions
• B60W 40/105 - Speed
• B60W 40/11 - Pitch movement
• B60W 40/114 - Yaw movement
• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
• G06F 17/17 - Function evaluation by approximation methods, e.g. interpolation or extrapolation, smoothing or least mean square method

Abstract

A gate driving circuit includes a capacitor connected between a first gate of a pull-down transistor and a control node, and a control transistor connected between the control node and a ground terminal and having a gate connected to the ground terminal.

IPC Classes  ?

• G09G 3/3266 - Details of drivers for scan electrodes

Abstract

The present invention relates to a biomarker for diagnosing immune-related diseases, a composition and kit for detecting the biomarker for diagnosing immune-related diseases, and a method for diagnosing immune-related diseases using same. According to the composition, kit, and method for diagnosing immune-related diseases in an aspect, it is possible to easily diagnose the level of immune-related diseases in a subject, whereby the subject's health can be monitored and immune-related diseases can be prevented and diagnosed.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material
• G01N 30/72 - Mass spectrometers

Abstract

The present disclosure relates to a method for mass production of extracellular vesicles by using a noxa protein-derived peptide and mesenchymal stem cells and, more specifically, to a method for mass production of extracellular vesicles having wound healing and immunomodulatory effects, wherein mesenchymal stem cells are cultured in a medium composition containing a noxa protein-derived peptide, glucose, sucrose, and 3-(N-morpholino)propanesulfonic acid [MOPS], whereby the extracellular vesicles can be obtained at high yield with high purity.

IPC Classes  ?

• C12N 5/073 - Embryonic cells or tissuesFoetal cells or tissues
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

The present disclosure relates to a system for measuring changes in the vital signs of poultry and a method for predicting whether poultry is infected with pathogens using the same. The present disclosure can be helpfully used to determine an overall health condition including the outbreak of various poultry diseases by measuring quantitative changes in vital signs of poultry in real time. In particular, the present disclosure provides reliable real-time information about changes in vital signs through comparison of body temperature and noise measurement values of poultry for each time period reflecting circadian changes of the poultry, rather than simple comparison of the body temperature and noise measurement values with simple reference values, and thus can be used for early diagnosis of highly infectious pathogens such as avian influenza virus and early isolation of confirmed cases, and ultimately for effective prevention of the spread of diseases.

IPC Classes  ?

• A01K 45/00 - Other aviculture appliances, e.g. devices for determining whether a bird is about to lay
• A01K 29/00 - Other apparatus for animal husbandry
• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
• G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry

Abstract

An apparatus and method for estimating a vehicle pitch relative to a road. The apparatus includes a wheel speed sensor part which obtains wheel speed data, an inertial measurement unit (IMU) sensor part which obtains IMU data, a preprocessing part which extracts a stop section and a moving section on the basis of the wheel speed data and the IMU data, and a slope estimation part which estimates a vehicle pitch in the stop section and a road slope in the moving section and estimates a vehicle pitch relative to a road on the basis of the vehicle pitch and the road slope.

IPC Classes  ?

• G01C 9/00 - Measuring inclination, e.g. by clinometers, by levels

Abstract

Provided are polynucleotides encoding variants of nitrous oxide reductase proteins, recombinant microorganisms including a foreign gene encoding a variant of a nitrous oxide reductase protein, and a composition comprising the recombinant microorganism or the variant of a nitrous oxide reductase protein for use in removing nitrous oxide in a sample.

IPC Classes  ?

• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli

Abstract

Proposed is a recyclable epoxy compound containing an α,β-unsaturated ketone group and/or a hydroxy ketone group bonded through an aldol reaction between a ketone group and an aldehyde group containing a hydroxyl group among non-toxic natural materials, without using a bisphenol A type epoxy, a toxic material. In addition, proposed are a method of preparing the same compound, an epoxy composite material containing the same compound, and a method of degrading the same composite material.

IPC Classes  ?

• C08G 59/24 - Di-epoxy compounds carbocyclic
• F03D 1/06 - Rotors
• C08G 59/68 - Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups characterised by the catalysts used
• C08G 59/50 - Amines
• C08G 59/06 - Polycondensates containing more than one epoxy group per molecule of polyhydroxy compounds with epihalohydrins or precursors thereof of polyhydric phenols

Abstract

The present invention relates to a pharmaceutical composition including an IL-32θ mutant for the prevention or treatment of inflammatory diseases and/or cancer and a use thereof. The Interleukin-32 theta mutant (IL-32θ mutant) of the present invention can inhibit inflammatory cytokines and chemokines, inflammatory mediators, and the metastasis and proliferation of cancer through intracellular pathways and can suppress the expression of Intracellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) in Human Umbilical Vein Endothelial Cells (HUVECs), and thus can be used for preventing and treating inflammatory diseases such as atherosclerosis through the inhibition of monocyte-endothelial cell adhesion. The mutant can also be utilized as a research material for various cancers and/or inflammatory diseases.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents
• C07K 14/54 - Interleukins [IL]

Abstract

The present disclosure relates to a method for producing mesenchymal stem cells from pluripotent stem cells and mesenchymal stem cells prepared by the method. The present disclosure enables mesenchymal stem cells having superior proliferation rate while having superior intrinsic biological activity to be obtained with high yield by sequentially performing three-dimensional suspension culture using pluripotent stem cells, particularly induced pluripotent stem cells (iPSCs), as starting cells and adherent culture of cell aggregates formed therethrough. The mesenchymal stem cells produced by the method of the present disclosure can be usefully used in compositions for treating bone diseases, cartilage diseases or inflammatory and autoimmune diseases owing to high differentiation efficiency into bone and cartilage and superior anti-inflammatory activity.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to: a synthetic promoter operably linked to a daptomycin biosynthetic gene cluster; a gene construct for producing daptomycin in which the synthetic promoter and a daptomycin biosynthetic gene cluster are operably linked; a recombinant expression vector for producing daptomycin containing the genetic construct; and a transformant for producing daptomycin that has been transformed with the recombinant expression vector, wherein the synthetic promoter can increase the transcriptional activity of the daptomycin biosynthetic gene cluster, and the transformant that has been transformed with the recombinant expression vector containing the synthetic promoter and the daptomycin biosynthetic gene cluster can be effectively used in the field of medicine and pharmacy by enabling mass production of daptomycin.

IPC Classes  ?

• C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for ActinomycesVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12P 21/00 - Preparation of peptides or proteins

Abstract

MycobacteriumStreptomycesStreptomyces sp. bacteria, and a use thereof. It was found that soil mixed with the microorganisms according to the present invention has increased levels of organic acids (including lactic acid, pyruvic acid, and serotonin) and decreased levels of fatty acids and lipids (including palmitic acid and linoleic acid). In addition, alpha waves of the laryngeal cortex increased and heart rate decreased, and thus a stabilizing effect on the autonomic nervous system was exhibited. That is, soil mixed with the microorganisms according to the present invention can provide healing activity such as an improvement in psychological health.

IPC Classes  ?

• A61K 35/74 - Bacteria
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like

Abstract

The present invention relates to: a recyclable epoxy compound; a method for preparing same; an epoxy composite material comprising same; and a decomposition method thereof, wherein the epoxy compound does not use bisphenol A-type epoxy which is a toxic material but comprises an α,β-unsaturated ketone group and/or a hydroxy ketone group obtained by combining, from among non-toxic natural raw materials, a hydroxyl-group-containing aldehyde group and a ketone group through an aldol reaction.

IPC Classes  ?

• C07D 301/12 - Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
• C08G 59/22 - Di-epoxy compounds
• C08G 59/50 - Amines
• C08G 59/44 - Amides
• C08G 59/40 - Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups characterised by the curing agents used
• C08G 59/68 - Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups characterised by the catalysts used

Abstract

The present disclosure relates to a method for producing extracellular vesicles from three-dimensionally cultured stem cells. The method of the present disclosure can produce stem cell-derived extracellular vesicles with a high yield through orbital shaking culture of stem cell aggregates in the presence of TGF-β and thus can be usefully used in an industrial-scale mass production process of exosomes that can be utilized as a pharmaceutical ingredient substituting for a cell therapeutic agent. Furthermore, the exosomes obtained by the method of the present disclosure have significantly improved immunoregulatory functions as compared to the exosomes produced by the existing method and, therefore, can be applied as a superior therapeutic composition for various inflammations or autoimmune diseases.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells

Abstract

In the present invention, among blood metabolites, amino acids, organic compounds and oxylipins that were statistically significantly differentiated from the control group, were selected from type 2 diabetes patients. Specifically, asparagine, aspartic acid, glutamic acid, cysteine, lysine, citric acid, and uric acid, and 12-oxo ETE, 15-oxo ETE, 9-oxo ODE, and 20-carboxy leukotriene B4, which are oxylipins, were confirmed to have cutoff values of AUC>0.7. In addition, the blood metabolites showed a significant difference between a DME patient group and a non-DME patient group, and thus were confirmed to be usable for accurate diagnosis of DME.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 30/72 - Mass spectrometers
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

Abstract

The present invention relates to an influenza virus surface protein-derived recombinant hemagglutinin (HA) protein forming a trimer and use thereof, and more specifically to a recombinant vector for producing an influenza virus surface protein-derived HA protein forming a trimer, a transformant transformed by the recombinant vector, a method for producing an influenza virus surface protein-derived HA protein forming a trimer using the recombinant vector, an influenza virus surface protein-derived HA protein produced by the method, and the use thereof in preventing, ameliorating or treating influenza virus-infected disease.

IPC Classes  ?

• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

The present invention relates to: a 3-fluoropyridine-based organic semiconductor compound for an electron donor, based on low cost and high processability and having a wide bandgap; an organic electronic device comprising same; and an organic solar cell comprising a photoactive layer including same as an electron donor. The 3-fluoropyridine-based organic semiconductor compound according to the present invention can be used as a photoactive layer material of a bulk heterojunction or layer-by-layer structure in combination with conventional donors or acceptors, and therefore, an organic solar cell with high performance/high transmittance can be provided.

IPC Classes  ?

• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 495/04 - Ortho-condensed systems
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• H10K 99/00 - Subject matter not provided for in other groups of this subclass
• H10K 30/00 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation

Abstract

The present invention relates to a method for electrospinning of a high-efficiency nanofiber air filter by using a PVDF-G-POEM double comb copolymer. According to the present invention, provided is a nanofiber air filter which: can adsorb both hydrophobic dust and hydrophilic dust; exhibits a uniform diameter distribution of nanofibers, thus compensating for the disadvantages of the prior art of the large diameter and non-uniform distribution of a filter; can exhibit excellent separation efficiency through the manufacture of nanofibers with a diameter similar to the mean free path of oxygen molecules; and has a slip effect due to a narrow fiber diameter, thus having high filter efficiency.

IPC Classes  ?

• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
• D01D 5/00 - Formation of filaments, threads, or the like

Abstract

A nonameric peptide represented by the amino acid sequence of SEQ ID NO: 1 or an enantiomer thereof according to the present invention is low in cytotoxicity and superb in terms of proteolysis stability, antibacterial activity, and anti-inflammatory activity and has a remarkable therapeutic effect on Gram-negative bacterial infectious diseases, sepsis, or septic shock. Accordingly, the peptide can be advantageously applied to an antibacterial composition, an anti-inflammatory composition, and a pharmaceutical composition for prevention or treatment of Gram-negative bacterial infectious diseases, sepsis, or septic shock.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A01N 37/46 - N-acyl derivatives
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 31/04 - Antibacterial agents

Abstract

The present invention relates to a recombinant Newcastle virus vector comprising a hemagglutinin gene of low pathogenic avian influenza, and a vaccine composition using same. The present invention includes the HA gene of A/Korean native chicken/Korea/N20-132/2020 (H9N2) LPAIV in the existing Newcastle virus vector, thereby being capable of obtaining excellent preventive effects against the Newcastle disease virus and low pathogenic avian influenza.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

The present invention relates to a probe set for an isothermal single reaction using a split T7 promoter and a use thereof. In the present invention, a design is made to introduce a split T7 promoter into a 3-way junction structure to produce a large quantity of fluorescent RNA aptamers at an isothermal temperature in the presence of a target molecule, and a nucleic acid biomarker can be detected rapidly and conveniently with only one enzyme in one pot. The probe set allows for various applications through high-sensitivity detection of multiple nucleic acid biomarkers and detection in which analysis is performed without an additional nucleic acid extraction process. In one pot, multiplex analysis can be conducted and molecular diagnosis can be made of various entities including viruses and pathogens.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

An embodiment of the present disclosure provides an extracellular matrix-based bioadhesive as an adhesive in the form of a composition including an extracellular matrix-containing hydrogel and a gelatin curing agent, wherein the extracellular matrix-containing hydrogel is gelatinized. Since the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure has the same or similar rheological properties as gelatin, the bioadhesive has flowability at a temperature of 30° C. or higher and may be evenly and easily applied to a lesion site in the body. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure may adhere well to the lesion site because of a level of adhesive strength that is about 2 to 6 times higher than that of fibrin glue used as a commercial tissue adhesive. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure is based on a tissue-derived extracellular matrix, and thus includes a tissue-derived wound healing component or a tissue regeneration component, and may be used for wound healing or tissue regeneration in addition to bioadhesive applications.

IPC Classes  ?

• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• A61L 24/10 - PolypeptidesProteins

Abstract

The present invention relates to a pharmaceutical composition, a food composition, a cosmetic composition, and a feed composition, each comprising an extract from oat sprouts and/or stems for alleviating hair loss or promoting hair growth, a pharmaceutical composition comprising an oat sprout and/or extract for preventing or treating hair loss, and a medical device. The oat sprout and/or extract of the present invention has an excellent effect of alleviating hair loss and promoting hair growth by encouraging the proliferation of HDP cells and the expression of related genes, and thus can be used in drugs, medical devices, feeds, foods, health functional foods, cosmetics, and so on which are useful for preventing and treating hair loss.

IPC Classes  ?

• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 29/281 - Proteins, e.g. gelatin or collagen
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
• A23P 10/20 - AgglomeratingGranulatingTabletting
• A23P 10/28 - TablettingMaking food bars by compression of a dry powdered mixture
• A23P 10/30 - Encapsulation of particles, e.g. foodstuff additives
• A61K 36/899 - Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• A61P 19/00 - Drugs for skeletal disorders
• A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
• A23K 50/00 - Feeding-stuffs specially adapted for particular animals

Abstract

The present invention relates to a fire-extinguishing microcapsule, a method for manufacturing same, and a fire-extinguishing composition comprising same, wherein the microcapsule comprises: a core containing a non-inflammable material; a first shell layer covering the core and containing inorganic nanoparticles and a water-soluble polymer; and a second shell layer covering the first shell layer and containing a polymer.

IPC Classes  ?

• A62D 1/00 - Fire-extinguishing compositionsUse of chemical substances in extinguishing fires
• B01J 13/14 - Polymerisation, crosslinking

Abstract

There are provided a flame retardant element for suppressing flame propagation when a fire occurs during the use of a lithium secondary battery, thereby ensuring safety of the secondary battery while in use, a method for manufacturing the flame retardant element, and a secondary battery module and a secondary battery pack comprising the flame retardant element. The proposed flame retardant element is a composite pad having a stack of at least two polymer resin single layers including fire extinguishing materials having different fire extinguishing and flame retardant mechanisms, the composite pad includes a first polymer resin single layer and a second polymer resin single layer, and the first polymer resin single layer includes the fire extinguishing material which takes effect in a lower temperature range than the second polymer resin single layer.

IPC Classes  ?

• C08K 3/22 - OxidesHydroxides of metals
• C08K 3/16 - Halogen-containing compounds
• H01M 50/143 - FireproofExplosion-proof

Abstract

An analog-to-digital converter (ADC) for converting an analog signal into a digital signal includes an amplifier circuit configured to receive the analog signal, and to generate a plurality of amplifier signals by amplifying the analog signal; a comparison circuit configured to compare a plurality of voltage levels corresponding to the plurality of amplifier signals with a positive reference voltage level and a negative reference voltage level, and to output conversion target signals based on a result of the comparison; and a converter circuit configured to convert the conversion target signals into a plurality of digital signals.

IPC Classes  ?

• H03M 1/12 - Analogue/digital converters
• H03M 1/36 - Analogue value compared with reference values simultaneously only, i.e. parallel type

Abstract

The present invention relates to a metal nanostructure preparation method and a metal nanostructure prepared thereby, the method comprising the steps of: (a) preparing a first metal template surface-coated with a polymeric micelle comprising an amphiphilic polymer; and (b) performing a galvanic replacement reaction between the first metal template and a second metal ion. According to the present invention, an amphiphilic polymer is used as a capping agent during galvanic replacement reaction so as to adsorb a micellar polymer on a metal template, thereby allowing a galvanic replacement reaction to be selectively performed, and thus, unlike a nanostructure with a delimited shape, such as hollow nanoparticles, prepared through a conventional technique, a nanostructure having a new two-dimensional structure including a nanostructure having a lot of pores formed between nanoparticles can be prepared, and since the mixing ratio of two types of solvents having different polarity indices is adjusted to control the size of the polymeric micelle adsorbed on the template, the structural characteristics of a finally prepared metal nanostructure can be changed.

IPC Classes  ?

• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• C22C 1/08 - Alloys with open or closed pores
• C22C 1/10 - Alloys containing non-metals
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The present invention relates to mesenchymal stem cells, extracellular vesicles isolated therefrom, and a use thereof. The mesenchymal stem cells of the present invention exhibit upregulated expression levels of at least one marker selected from among SPP1, PLAU, ITGA6, CENPI, and BUB1 and/or a downregulated expression level of the marker PTGS2, thereby remarkably decreasing levels of inflammatory cytokines such as TNF-α, IL-6, etc., and are therefore effective for preventing, ameliorating, alleviating, or treating various inflammatory diseases. Specifically, when administered into interstitial cystitis/bladder pain syndrome (IC/BPS) animal models, the mesenchymal stem cells or stem cell-derived extracellular vesicles isolated therefrom of the present invention restore the inner bladder wall broken down in the IC/BPS induction process and palliate inflammation, thus exhibiting excellent therapeutic efficacy for interstitial cystitis/bladder pain syndrome. In addition, the mesenchymal stem cells or the stem cell-derived extracellular vesicles isolated therefrom of the present invention has excellent wound healing effects and thus can be advantageously used for wound healing.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• C12N 13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 13/10 - Drugs for disorders of the urinary system of the bladder
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The present invention relates to stem cell-derived extracellular vesicles, and a use thereof. Stem cell-derived extracellular vesicles of the present invention allow one or more proteins selected from COL6A1, COL6A3, TNC, EIF4E, HSP90AB1, HSP90B1, RAC1, TGF-β1 and TGM2 to be highly expressed, so as to remarkably reduce the amounts of inflammatory cytokines such as TNF-α and IL-6, and thus are effective in the prevention, reduction, alleviation, or treatment of various inflammatory diseases. Particularly, when administered to an animal model of interstitial cystitis/bladder pain syndrome (IC/BPS), the stem cell-derived extracellular vesicles of the present invention allow the lining of the bladder, damaged during the induction of IC/BPS, to be restored, the degree of inflammation to be reduced, and bladder internal pressure to be restored, and exhibit a voiding cycle similar to that of a control group, and thus the extracellular vesicles have the excellent effect of treating interstitial cystitis/bladder pain syndrome. In addition, stem cell-derived extracellular vesicles of the present invention remarkably increase the migration of cells, and have an excellent wound healing effect, and thus can be effectively used for wound healing.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 13/10 - Drugs for disorders of the urinary system of the bladder
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

Disclosed are an apparatus and method for correcting a transition error of a pulse width-based current domain in-memory neural network calculator. The apparatus for correcting a transition error of a pulse width-based current domain in-memory neural network calculator according to one embodiment of the present invention may comprise: an input unit for applying input data and unit pulse data on the basis of a pulse width modulation method; a calculation unit which obtains a first calculation result by performing a calculation based on the input data and a weight of a neural network, and obtains a second calculation result by performing a calculation based on the unit pulse data; and a charge integration unit for sampling a charge corresponding to an output current obtained from the first calculation result and the second calculation result.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

The present invention relates to a method for manufacturing a semi-transparent solar cell including a high transmittance charge transport layer, and more particularly, to a solar cell having high transmittance and excellent performance in a visible light region by using a composite transparent electrode composed of a charge transport layer and an electrode having high transmittance and high mobility and changing a composition thereof. The semi-transparent solar cell into which the composite transparent electrode is used according to the present invention increases the transmittance of the light which passed, after being incident on the solar cell, through a light receiving electrode and is utilized for power generation in a photoactive layer, thereby appearing semi-transparent in the visible light region and having excellent transmittance. In addition, the semi-transparent solar cell according to the present invention can improve the photoelectric conversion efficiency (PCE) based on the high mobility characteristics of the composite transparent electrode.

IPC Classes  ?

• H01L 51/44 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation - Details of devices
• H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof

Abstract

A display apparatus is disclosed, which includes a pixel. The pixel includes first through fifth transistors and a light emitting element. The first transistor includes a control electrode electrically connected to a first node, an input electrode that receives a first power voltage and an output electrode electrically connected to the light emitting element. The second transistor includes a control electrode that receives a scan signal, an input electrode that receives a grayscale data voltage and an output electrode electrically connected to a second node. The third transistor includes a control electrode electrically connected to the second node, an input electrode that receives a reference voltage and an output electrode electrically connected to the first node. The fourth transistor includes a control electrode that receives the scan signal, an input electrode that receives a bias data voltage and an output electrode electrically connected to the first node. The fifth transistor includes a control electrode that receives a sensing control signal, an input electrode that receives an initialization voltage and an output electrode electrically connected to the light emitting element.

IPC Classes  ?

• G09G 3/3225 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED] organic, e.g. using organic light-emitting diodes [OLED] using an active matrix

Abstract

The present invention relates to an anti-freezing disinfectant composition and a preparation method therefor. The anti-freezing disinfectant according to the present invention contains potassium hydroxide, potassium acetate, sodium chloride, and sodium sulfate and exhibits anti-bacterial and anti-viral activities within a short time even at a low temperature. Thus, it can be used to kill infectious bronchitis virus or poultry influenza virus.

IPC Classes  ?

• A01N 59/08 - Alkali metal chloridesAlkaline earth metal chlorides
• A01N 59/02 - SulfurSeleniumTelluriumCompounds thereof

Abstract

The present disclosure relates to a composition containing extracellular vesicles isolated from skeletal muscle-derived stem cells as active ingredients, which exhibits the effect of skin aging delay, wound healing, scar reduction and skin whitening, thereby improving skin condition. The present disclosure can not only utilize tissues wasted after surgical operation, thus allowing easy supply of raw materials, but also takes advantage of natural substances, thereby being free from the risk of side effects even upon long-term administration. The composition of the present disclosure promotes the secretion of collagen, reduces reactive oxygen species and promotes re-epithelialization at wound site while remarkably inhibiting melanocyte proliferation, tyrosinase activity and melanogenesis. Accordingly, it can facilitate effective recovery from skin tissue damage caused by oxidative stress, physical wound, intrinsic aging at cell or tissue levels, or hyperpigmentation.

IPC Classes  ?

• A61K 35/34 - MusclesSmooth muscle cellsHeartCardiac stem cellsMyoblastsMyocytesCardiomyocytes
• A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
• A61P 17/00 - Drugs for dermatological disorders
• A61Q 19/00 - Preparations for care of the skin

Abstract

Disclosed are a method and apparatus for self-training of machine reading comprehension to improve domain adaptation. The method for self-training of the machine reading comprehension may include generating a pseudo training data set comprising pseudo-questions and pseudo-answers in response to a change in a domain to which a trained machine reading comprehension model is to be applied, refining the pseudo training data set, and retraining the machine reading comprehension model and a pseudo-question generator that generates the pseudo-questions using the refined pseudo training data set.

IPC Classes  ?

• G06N 20/00 - Machine learning
• G06F 40/289 - Phrasal analysis, e.g. finite state techniques or chunking

Abstract

A hair perm forming method using electrolyzed water multiple times or for a predetermined period of time or more was revealed to have effects that cause very little damage to the hair to enable repeated treatments, enable perming of damaged hair and blonde hair compared with existing methods, show oxidative power higher than that of hydrogen peroxide, cause less hair damage, suppress dandruff bacteria, and significantly decrease the elution of dyes after perming. Therefore, the hair perm forming method can be advantageously used to effectively form a perm without harm to the human body. In addition, the washing of dyed and permed hair, dyed hair, and bleached hair with electrolyzed water, compared with washing with distilled water, has advantages in that the tensile strength of hair is maintained and the dye loss from the dyed hair is less.

IPC Classes  ?

• A45D 7/04 - Processes of waving, straightening or curling hair chemical
• C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection
• C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange

Abstract

Disclosed herein is a method for compressing an image for machine vision, the method including detecting objects in an input image using an object detection network, generating a foreground image including bounding boxes corresponding to the objects and a background image, which is an image acquired by excluding the bounding boxes from the input image, encoding the foreground image and the background image, and decoding the encoded foreground image and the encoded background image.

IPC Classes  ?

• G06T 7/194 - SegmentationEdge detection involving foreground-background segmentation
• G06V 10/20 - Image preprocessing
• G06V 10/28 - Quantising the image, e.g. histogram thresholding for discrimination between background and foreground patterns
• G06T 9/00 - Image coding

Abstract

The present invention relates to: recombinant microorganisms expressing lipoxygenase; and recombinant microorganisms co-expressing lipoxygenase and chlorella-derived decarboxylase. It was confirmed that when using lipoxygenase-based recombinant microorganisms according to the present invention as whole-cell biocatalysts, hydroxy fatty acids can be produced from unsaturated fatty acids. In addition, it was confirmed that when using the recombinant microorganisms co-expressing lipoxygenase and chlorella-derived decarboxylase as whole-cell biocatalysts, secondary fatty alcohols can be produced from unsaturated fatty acids. Thus, the recombinant microorganisms constructed in the present invention can be used in various ways in the field of hydroxy fatty acid and secondary fatty alcohol production.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12P 7/6409 - Fatty acids
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating muscular atrophy or cachexia, comprising an extract containing ginseng-derived gintonin, a fraction thereof, or gintonin, as an active ingredient.

IPC Classes  ?

• A61K 36/258 - Panax (ginseng)
• A61K 38/14 - Peptides containing saccharide radicalsDerivatives thereof
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

A display apparatus includes a display panel, a driving controller and a data driver. The display panel displays an image based on input image data. The driving controller generates a data signal based on the input image data, determines an optical flow based on previous frame data of the input image data and present frame data of the input image data and determines a user's self-motion using the optical flow. The data driver converts the data signal to a data voltage and outputs the data voltage to the display panel.

IPC Classes  ?

• G06T 7/207 - Analysis of motion for motion estimation over a hierarchy of resolutions
• G02B 27/01 - Head-up displays
• G06T 3/40 - Scaling of whole images or parts thereof, e.g. expanding or contracting
• G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]Salient regional features

Abstract

The present invention relates to a composition for promoting the proliferation of stem cells, and a composition for preventing or treating ischemic diseases. The present invention makes it possible to identify key fragments of FGF2 protein that interact most effectively with FGFR1, and use the fragments to effectively induce diverse biological processes, including the in vitro proliferation of stem cells and the promotion of angiogenesis, involving the FGFR1-FGF2 signaling pathway. In addition, the present invention makes it possible to identify, in the FGF2 protein, a core part that substantially mutually binds with FGFR1, which is a receptor, and rapidly and reliably investigate basic therapeutic agent candidate materials for various diseases, such as cancer, caused by excessive angiogenesis, on the basis of whether or not the interaction between the FGF2 protein and FGFR1 is impeded.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61K 38/18 - Growth factorsGrowth regulators
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A23L 33/18 - PeptidesProtein hydrolysates
• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a method for mass production of extracellular vesicles by using a noxa protein-derived peptide and mesenchymal stem cells and, more specifically, to a method for mass production of extracellular vesicles having wound healing and immunomodulatory effects, wherein mesenchymal stem cells are cultured in a medium composition containing a noxa protein-derived peptide, glucose, sucrose, and 3-(N-morpholino)propanesulfonic acid [MOPS], whereby the extracellular vesicles can be obtained at high yield with high purity.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof

Abstract

The present invention relates to a virtual crop cultivation system using augmented reality and virtual reality. The virtual crop cultivation system using augmented reality and virtual reality comprises: a server which provides a mobile game application for virtual crop cultivation, and stores crop cultivation game data, crop cultivation result data, user data, and service data; and a user terminal which runs the mobile game application, receives the crop cultivation game data from the server, and receives a user input for the virtual crop cultivation so as to generate and output the crop cultivation result data on the basis of the received crop cultivation game data and user input. The server may provide virtual crop cultivation game data in either augmented reality or virtual reality in consideration of image information collected from an image sensor provided in an actual crop cultivation environment.

IPC Classes  ?

• A63F 13/825 - Fostering virtual characters
• A63F 13/335 - Interconnection arrangements between game servers and game devicesInterconnection arrangements between game devicesInterconnection arrangements between game servers using wide area network [WAN] connections using Internet
• G06Q 50/10 - Services
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services

Abstract

A high precision position estimation method through a road shape classification-based map matching implemented by a high precision position estimation system of an autonomous vehicle includes classifying a road into a straight lane, a curved lane, and a clothoid curve lane by the lane matching between a sensor lane segment and a map lane segment, generating a movement amount value calculated by applying a geometric feature-based map matching or an optimization-based map matching to the classified lane as a covariance matrix, and calculating the latitude, longitude, and traveling direction of a vehicle to be estimated by combining the covariance matrix with sensor measurement values of a vehicle speed and a yaw rate by an extended Kalman filter.

IPC Classes  ?

• G01C 21/16 - NavigationNavigational instruments not provided for in groups by using measurement of speed or acceleration executed aboard the object being navigatedDead reckoning by integrating acceleration or speed, i.e. inertial navigation
• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles
• G01C 21/34 - Route searchingRoute guidance

Abstract

The present invention relates to a plant cultivator. The plant cultivator can comprise: a housing unit having a cultivating space in which a plant can be cultivated, and comprising a plurality of image sensors provided on the upper surface to capture images of the cultivating space; a plant planting pot apparatus accommodated in the cultivating space and having a body part, which has a planting space in which a plant is planted, and a learning gardening control module part which is provided in one area of the body part; and a cultivator control unit providing a user terminal with at least one of images obtained by the plurality of image sensors.

IPC Classes  ?

• A01G 9/24 - Devices for heating, ventilating, regulating temperature, or watering, in greenhouses, forcing-frames, or the like
• A01G 9/02 - Receptacles, e.g. flower-pots or boxes Glasses for cultivating flowers
• A01G 9/26 - Electric devices
• G09B 19/00 - Teaching not covered by other main groups of this subclass
• G06Q 50/10 - Services
• A01G 27/00 - Self-acting watering devices, e.g. for flower-pots
• A01G 13/08 - Mechanical apparatus for circulating the air

Abstract

The present invention relates to a composition comprising a defensin-derived decameric peptide as an active ingredient for prevention or treatment of sepsis and, more specifically, to a pharmaceutical composition comprising the defensin-derived decameric peptide Pro10-1 or Pro10-1D as an active ingredient for prevention or treatment of sepsis or septic shock. In the present invention, Pro10-1 or Pro10-1D was identified to have an antibacterial activity against Gram-negative bacteria. Particularly, with increased cationicity and decreased hydrophobicity given thereto, Pro10-1D, which has arginine (Arg) and D-amino acid conversion added at the N-terminus thereof, was identified to decrease in toxicity, have improved permeability to negatively charged bacterial membranes, and exhibit the effects of excellent antibacterial activity, resistance to proteinases, endotoxin neutralization/clearance, and biofilm formation inhibition. Furthermore, Pro10-1D was identified to exhibit a remarkable anti-inflammatory effect by inhibiting TLR4 downstream, alleviate inflammatory insult in sepsis mouse models, and have a protective effect against organ dysfunction in sepsis mice. Thus, Pro10-1 or Pro10-1D of the present invention can find advantageous applications as a novel peptide antibiotic for effective treatment of sepsis or septic shock.

IPC Classes  ?

• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61P 31/04 - Antibacterial agents
• A23L 33/18 - PeptidesProtein hydrolysates

Abstract

The present invention relates to a system for measuring changes in vital signs of poultry and a method for predicting whether poultry is infected with pathogens by using same. The present invention can be helpfully used to determine an overall health condition including the outbreak of various poultry diseases by measuring quantitative values of changes in biological vitality of poultry in real time. In particular, the present invention provides reliable real-time information about changes in biological vitality through a comparison of body temperature and noise measurement values of poultry for each time period reflecting circadian changes of the poultry, rather than a simple comparison of the body temperature and noise measurement values with simple reference values, and thus can be used for early diagnosis of highly infectious pathogens such as avian influenza virus and early isolation of confirmed cases, and ultimately the effective prevention of the spread of diseases.

IPC Classes  ?

• G06Q 50/02 - AgricultureFishingForestryMining
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A01K 29/00 - Other apparatus for animal husbandry
• A01K 31/00 - Housing birds
• A01K 31/22 - Poultry runs
• G08B 21/18 - Status alarms
• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu

Abstract

The present application relates to a method for screening customized postbiotics, the method comprising the steps of: culturing lactic acid bacteria; extracting a plurality of metabolites from the cultured lactic acid bacteria; analyzing the plurality of extracted metabolites by using multiple mass spectrometry; converting the results of the analysis using multiple mass spectrometry into statistical values; applying multivariate statistical analysis to the values, and thereby grouping the plurality of metabolites; and analyzing the phenotypes of the grouped metabolites.

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• A61K 35/74 - Bacteria
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

Abstract

The present invention provides an antibacterial or antiviral composition comprising hydroxyapatite and calcium hydroxide, and a manufacturing method therefor. When advantage is taken thereof, an antibacterial or antiviral composition comprising hydroxyapatite and calcium hydroxide and a manufacturing method therefor according to the present invention allow the isolation and mass production of a composition containing hydroxyapatite and calcium hydroxide from shells. If prepared, a product comprising hydroxyapatite and calcium hydroxide exhibits excellent antibacterial and antiviral effects.

IPC Classes  ?

• A01N 59/26 - PhosphorusCompounds thereof
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 7/61 - Additives non-macromolecular inorganic
• C08J 7/04 - Coating
• C08J 5/18 - Manufacture of films or sheets
• C08K 3/22 - OxidesHydroxides of metals
• A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings

Abstract

Disclosed are an analog-to-digital converter (ADC), an electronic device including the ADC, and an operating method of the ADC. The ADC includes a first stage that includes a plurality of channels, generates a first sampling signal by sequentially sampling a first analog signal based on time interleaving, and generates a first digital signal and a first residual signal corresponding to the first analog signal by performing analog-to-digital conversion based on the first sampling signal, an amplifier that amplifies the first residual signal, and a second stage that includes a plurality of channels, generates a second sampling signal by sequentially sampling the amplified first residual signal based on time interleaving, and generates a second digital signal and a second residual signal corresponding to the first analog signal by performing analog-to-digital conversion based on the second sampling signal. The number of the plurality of channels included in the first stage is odd-numbered.

IPC Classes  ?

• H03M 1/12 - Analogue/digital converters
• H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter

Abstract

A display device includes a scan write line for receiving a scan write signal, a first driving voltage line for receiving a first driving voltage, a first data line for receiving first data voltages, a second data line for receiving second data voltages, and a sub-pixel connected to the scan write line, the first data line, the second data line, and the first driving voltage line, wherein the sub-pixel includes a light emitting element connected to the first driving voltage line, a constant current generator configured to apply a driving current to the light emitting element according to a first data voltage among the first data voltages of the first data line, and a light emission period controller configured to control a light emission period of the light emitting element according to a second data voltage among the second data voltages of the second data line.

IPC Classes  ?

• G09G 3/3266 - Details of drivers for scan electrodes
• G09G 3/3291 - Details of drivers for data electrodes in which the data driver supplies a variable data voltage for setting the current through, or the voltage across, the light-emitting elements

Abstract

A barristor junction array device and a manufacturing method therefor are disclosed. A barristor junction array device according to one embodiment comprises: a substrate; a two-dimensional semiconductor formed on the substrate in a first direction; and graphene formed on the two-dimensional semiconductor in a second direction, wherein a barristor device is formed at each position at which the two-dimensional semiconductor and the graphene are bonded.

IPC Classes  ?

• H01C 7/10 - Non-adjustable resistors formed as one or more layers or coatingsNon-adjustable resistors made from powdered conducting material or powdered semi-conducting material with or without insulating material voltage responsive, i.e. varistors
• H01C 17/00 - Apparatus or processes specially adapted for manufacturing resistors
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

A scan driver includes stage circuits, wherein each of the stage circuits includes a first transistor, wherein a first electrode thereof is coupled to a first node, a second electrode thereof is coupled to an input carry line, and a gate electrode thereof is coupled to a first clock line; and a capacitor, wherein a first electrode thereof is coupled to the first node and a second electrode thereof is coupled to a second node, wherein the second node is coupled to an output carry line, and the second node is selectively coupled to one of a first power voltage line and a second power voltage line.

IPC Classes  ?

• G09G 3/3266 - Details of drivers for scan electrodes
• G09G 3/3233 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED] organic, e.g. using organic light-emitting diodes [OLED] using an active matrix with pixel circuitry controlling the current through the light-emitting element

Abstract

The present invention is to provide multilayered multiple quantum dot-doped nanoparticles, each of the multiple quantum dot-doped nanoparticles has a structure consisting of an inorganic core particle, a quantum dot-embedded layer, and a silica/quantum dot composite shell. The multiple quantum dot-doped nanoparticles can be used to detect biomolecules with improved quantum yield (QY) and brightness while maintaining a large area covered by the quantum dots and stable bonds of the quantum dots. Therefore, the multiple quantum dot-doped nanoparticles are suitable for bioapplications, including bioplatforms and highly sensitive methods for detecting biomolecules.

IPC Classes  ?

• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C09K 11/88 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

In the present invention, among blood metabolites, amino acids, organic compounds and oxylipins that were statistically significantly differentiated from the control group, were selected from type 2 diabetes patients. Specifically, asparagine, aspartic acid, glutamic acid, cysteine, lysine, citric acid, and uric acid, and 12-oxo ETE, 15-oxo ETE, 9-oxo ODE, and 20-carboxy leukotriene B4, which are oxylipins, were confirmed to have cutoff values of AUC>0.7. In addition, the blood metabolites showed a significant difference between a DME patient group and a non-DME patient group, and thus were confirmed to be usable for accurate diagnosis of DME.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a method for producing mesenchymal stem cells from pluripotent stem cells and to mesenchymal stem cells produced by the method. The present invention enables mesenchymal stem cells having an excellent proliferation rate while having superior intrinsic biological activity to be obtained in high yield by sequentially performing three-dimensional suspension culture by using pluripotent stem cells, particularly induced pluripotent stem cells (iPSCs), as starting cells, and adherent culture of cell aggregates formed through same. In addition, mesenchymal stem cells produced by the method of the present invention demonstrate high efficiency of differentiation into bone and cartilage and have excellent anti-inflammatory activity, and thus can be usefully used as compositions for treatment of bone diseases, cartilage diseases, or inflammation and autoimmune diseases.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 19/00 - Drugs for skeletal disorders
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to a method for producing extracellular vesicles from three-dimensionally cultured stem cells, and the method of the present invention can produce stem cell-derived extracellular vesicles with a high yield by the orbital shaking culture of stem cell aggregates in the presence of TGF-β and thus can be advantageously used in an industrial scale mass-production process of exosomes that can be utilized as a pharmaceutical ingredient substituting for a cell therapeutic agent. Furthermore, the exosomes obtained by the method of the present invention have significantly improved immunoregulatory functions compared with exosomes produced by a conventional method, and therefore can also be applied as an excellent therapeutic composition for various inflammations or autoimmune diseases.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention relates to an influenza virus surface protein-derived recombinant hemagglutinin (HA) protein forming a trimer, and a use thereof, and, specifically, to: a recombinant vector for producing an influenza virus surface protein-derived HA protein forming a trimer; a transformant transformed with the recombinant vector; a method for producing the influenza virus surface protein-derived HA protein forming a trimer, by using the recombinant vector; the influenza virus surface protein-derived HA protein forming a trimer, produced by the method; and a use thereof for preventing, alleviating, or treating influenza virus infection diseases.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses

Abstract

A display panel, a pixel circuit, and a display device are disclosed. The display panel includes sub-pixels and a driver driving the sub-pixels. Each sub-pixel includes: an emission element; a first transistor configured to generate a driving current; a constant current control circuit configured to receive a reference voltage and a bias voltage for setting a value of the driving current and including a first capacitor configured to store a first compensation voltage generated by adding a threshold voltage of the first transistor to a difference between the bias voltage and the reference voltage; and a pulse width control circuit configured to receive a data voltage used to determine an emission duration of the emission element and including a second transistor configured to control a pulse width of the driving current according to the data voltage and a second capacitor configured to store a second compensation voltage corresponding to a threshold voltage of the second transistor.

IPC Classes  ?

• G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]

Abstract

A display panel includes sub-pixels each including a light-emitting element and a pixel circuit including a first transistor and a second transistor; a timing control unit to generate bias data based on first characteristic information of the first transistor, and generate correction data based on second characteristic information of the second transistor; and a data sensing driving unit configured to receive the bias data and the correction data, and output a bias voltage and a grayscale voltage to the pixel circuit. The pixel circuit includes the first transistor to output a driving current to the light-emitting element; a first driving circuit to control a magnitude of the driving current based on the bias voltage; and a second driving circuit including the second transistor and configured to control a pulse width of the driving current based on the grayscale voltage.

IPC Classes  ?

• G09G 3/36 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix by control of light from an independent source using liquid crystals
• H03K 3/0233 - Bistable circuits
• G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]

Abstract

Disclosed herein are a refrigerator, a method of controlling the same, and a refrigerator system including the refrigerator. The refrigerator includes a controller for inputting information on food and controlling the temperature of a supercooling compartment based on the input information, thereby realizing a storage condition optimized for food. The information on the food includes food type and food load information. By determining a storage temperature and the amount of supplied cold air according to the food, it is possible to store the food in a fresh state for a relatively long period of time.

IPC Classes  ?

• F25D 29/00 - Arrangement or mounting of control or safety devices
• F25D 23/12 - Arrangements of compartments additional to cooling compartmentsCombinations of refrigerators with other equipment, e.g. stove
• F25D 17/06 - Arrangements for circulating cooling fluidsArrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection by forced circulation
• F25D 17/08 - Arrangements for circulating cooling fluidsArrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection by forced circulation using ducts

Abstract

The present invention relates to an extinguishing composition and comprises an extinguishing material and a capsule containing the extinguishing material, and the extinguishing material comprises calcium bromide (CaBr2).

IPC Classes  ?

• A62D 1/00 - Fire-extinguishing compositionsUse of chemical substances in extinguishing fires
• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells

Abstract

The present invention relates to a composition for preventing, treating, and alleviating atopic dermatitis, comprising AB1711, which is a flavone-resveratrol conjugate compound, or a salt thereof, wherein the composition can prevent, treat, and alleviate atopic dermatitis by inhibiting EGR-1, which is a transcription factor involved in the expression of POMC that is a precursor of various cytokines, chemokines, and beta-endorphins that cause atopic dermatitis.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 17/00 - Drugs for dermatological disorders
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61Q 19/00 - Preparations for care of the skin

Abstract

Provided are a flame-retardant member, a method for manufacturing such flame-retardant member, and a secondary battery module and a secondary battery pack comprising such flame-retardant member, the flame-retardant member blocking flames from spreading any further when a fire breaks out while using a lithium secondary battery, thereby enabling safety of use of the secondary battery to be obtained. The flame-retardant member, proposed in the present invention, is a composite pad formed by laminating two or more polymer resin monolayer films each comprising a fire-extinguishing material having a different fire-extinguishing and flame-retardant substrate from the other. The composite pad comprises a first polymer resin monolayer film and a second polymer resin monolayer film, wherein, compared to the second polymer resin monolayer film, the first polymer resin monolayer film comprises a fire-extinguishing material which reacts at a lower temperature range.

IPC Classes  ?

• B32B 27/18 - Layered products essentially comprising synthetic resin characterised by the use of special additives
• H01M 50/24 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders characterised by physical properties of casings or racks, e.g. dimensions adapted for protecting batteries from their environment, e.g. from corrosion
• C09K 21/14 - Macromolecular materials
• A62D 1/00 - Fire-extinguishing compositionsUse of chemical substances in extinguishing fires
• A62C 3/16 - Fire prevention, containment or extinguishing specially adapted for particular objects or places in electrical installations, e.g. cableways
• B32B 27/28 - Layered products essentially comprising synthetic resin comprising copolymers of synthetic resins not wholly covered by any one of the following subgroups
• C08K 3/22 - OxidesHydroxides of metals
• C08K 3/16 - Halogen-containing compounds
• C08K 3/016 - Flame-proofing or flame-retarding additives

Abstract

Disclosed is a method of tracking an object and apparatuses performing the same, the method including generating a plurality of candidate particles corresponding to an object in a video frame to track the object, and tracking the object by generating optimal particles corresponding to a position of the object in the video frame based on similarities of the plurality of candidate particles with respect to the object.

IPC Classes  ?

• G06T 7/20 - Analysis of motion
• G06F 17/18 - Complex mathematical operations for evaluating statistical data
• G06K 9/62 - Methods or arrangements for recognition using electronic means
• G06N 3/08 - Learning methods

Abstract

In a method for producing acetoin, butanediol, or butanol from ethanol according to the present invention, a cell-free catalysis method was used by designing an artificial synthetic pathway so that proteins of NOX, EtDH, FLS, BDH, and DDH and variant proteins thereof exhibit cascade catalytic activity as enzymes. Compared to existing fermentation methods using microorganisms, the production method according to the present invention does not require cell growth and has a short synthetic pathway, a fast reaction rate, high yield and productivity, adjustment of targeted reaction conditions is convenient, and butanol may be effectively produced. Moreover, same may be reused numerous times by fixing the proteins to nano-particles, and are also effective for producing acetoin, butanediol, or butanol, thus being economical. Therefore, the production method may be usefully adopted in the relevant industries requiring acetoin, butanediol, or butanol.

IPC Classes  ?

• C12N 9/88 - Lyases (4.)
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12P 7/18 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
• C12P 7/26 - Ketones
• C12P 7/16 - Butanols
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)

Abstract

A hair perm forming method using electrolyzed water multiple times or for a predetermined period of time or more of the present invention was revealed to have effects that cause very little damage to the hair to enable repeated treatments, enable perming of damaged hair and blonde hair compared with existing methods, show oxidative power higher than that of hydrogen peroxide, cause less hair damage, suppress dandruff bacteria, and significantly decrease the elution of dyes after perming. Therefore, the hair perm forming method using electrolyzed water multiple times or for a predetermined period of time or more of the present invention can be advantageously used as a method capable of effectively forming a perm without harm to the human body in the field of hair perm forming. In addition, the washing of dyed and permed hair, dyed hair, and bleached hair with electrolyzed water, compared with washing with distilled water, has advantages in that the tensile strength of hair is maintained and the dye loss from the dyed hair is less.

IPC Classes  ?

• A61K 8/96 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution
• A61Q 5/04 - Preparations for permanent waving or straightening the hair
• A45D 7/04 - Processes of waving, straightening or curling hair chemical
• C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis

Abstract

The present invention relates to a method for enzymatically producing beta amino acids by using a novel ester hydrolase, and more specifically, to a method whereby the productivity of a beta-amino acid can be increased by using a novel ester hydrolase (lipase/esterase) when synthesizing a beta-keto acid from a beta-keto ester during the process of synthesizing the beta-amino acid.

IPC Classes  ?

• C12P 13/04 - Alpha- or beta-amino acids
• C12N 9/10 - Transferases (2.)
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)

Abstract

The present invention relates to a composition for production of methanol by using multi-enzyme-based Mn-enzyme hybrid cascade reactions and a method for production of methanol from carbon dioxide by using same. In the present invention, a Mn-enzyme hybrid cascade system composed of Clostridium carboxidivorans-derived formate dehydrogenase (CcFDH), PseFusmonas cepacian genomvar II-derived formate dehydrogenase (PcFalDH), Saccharomyces cerevisiae-derived alcohol dehydrogenase (ScADH), and Mn ions is constructed, whereby methanol can be produced from carbon dioxide more stably and effectively.

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 11/14 - Enzymes or microbial cells immobilised on or in an inorganic carrier
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12P 7/04 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic

Abstract

A display device includes: a plurality of pixels, each of which is connected to a corresponding one of a plurality of scan lines, and a scan driver including a plurality of stages, each of which supplies a scan signal to a corresponding one of the scan lines, each of the stages includes: a node controller which supplies a second output signal of a previous stage to a first node based on an input signal of a first clock terminal or a first output signal of the previous stage, a first inverter connected between the first node and a second node, a buffer which supplies a voltage of the second node to a first output terminal based on an input signal of a second clock terminal, and a second inverter connected between the first output terminal and a second output terminal.

IPC Classes  ?

• G09G 3/3266 - Details of drivers for scan electrodes
• G09G 3/20 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix

Abstract

Disclosed are a method for monitoring a baby and devices for performing same. A method for monitoring a baby according to an embodiment comprises the steps of: acquiring environment information relating to an environment in which a camera is installed and monitoring a baby is to be performed, and camera information relating to the camera; and assigning a virtual space corresponding to the environment on the basis of the environment information and the camera information.

IPC Classes  ?

• G08B 21/02 - Alarms for ensuring the safety of persons
• H04N 7/18 - Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
• G06N 20/00 - Machine learning

Abstract

The present invention relates to a composition for inducing the proliferation of stem cells and a composition for enhancing pluripotency. The compositions of the present invention improve the proliferation rate and pluripotency of pluripotent stem cells while lowering the tumorigenic potential of the stem cells, thus improving both therapeutic efficacy and safety of the stem cells simultaneously. The present invention may be utilized in a method for proliferating stem cells in vitro to obtain a therapeutically effective amount of pluripotent stem cells and in a process of storing and culturing stem cells while keeping same in an undifferentiated state up until the point of injection into a human body.

IPC Classes  ?

• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings