Abstract

The present invention relates to a method and an apparatus for designing a WMMSE beamforming matrix robust to channel errors for MU-MISO systems. A method for transmitting signals from a base station in a communication system according to an embodiment of the present invention may include the steps of: receiving, from a mobile station, channel feedback information generated based on a channel between the base station and the mobile station; determining a beamforming matrix that maximizes the weighted sum rate (WSR) using the channel feedback information; and transmitting a signal to the mobile station based on the beamforming matrix, wherein the channel between the base station and the mobile station may consist a first component corresponding to the channel feedback information and a second component corresponding to a quantization error, and the beamforming matrix may be determined based on the second component corresponding to the quantization error.

IPC Classes  ?

• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

The present disclosure is characterized by reducing the data dimension of an attention operation through row clustering on the basis of the fact that most rows constituting an attention score of a transformer have similar patterns.

IPC Classes  ?

• G06F 17/17 - Function evaluation by approximation methods, e.g. interpolation or extrapolation, smoothing or least mean square method
• G06F 17/16 - Matrix or vector computation

Abstract

An apparatus for synthesizing nucleic acids and a method for synthesizing nucleic acids using the same. The apparatus includes a first substrate including a surface on which the nucleic acids are synthesized, a second substrate including a deprotection solution, a transporter configured to move the first substrate or the second substrate, and a transporter controller in operable communication with the transporter.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

Abstract

According to an embodiment of the present invention, a robotic system for remote endoscopic diagnosis between a first area and a second area separated from the first area comprises: a master device comprising a handle unit operated by a user's manipulation input; and a slave device configured to receive analysis results related to one or more movements of the handle unit according to the operation of the handle unit and perform one or more slave operations corresponding to the one or more received movements of the handle unit. The one or more slave operations include an 8-degree-of-freedom operation.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 34/37 - Leader-follower robots
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
• A61B 34/30 - Surgical robots

Abstract

Proposed is a mobile robot utilizing the uncertainty of map matching poses for localization. The mobile robot includes a point cloud sensor which acquires point cloud data through scanning, a matching pose calculation part which applies a pre-registered point cloud map and the point cloud data to a pre-registered scan-map matching algorithm to calculate a map-matching pose of the mobile robot, and an uncertainty estimation part which estimates uncertainty of the map-matching pose on the basis of a probability distribution of a preset pose space around the map-matching pose. Through this, the uncertainty of the map-matching pose is estimated to evaluate the reliability of the map-matching pose, enabling more precise localization.

IPC Classes  ?

• G05D 1/246 - Arrangements for determining position or orientation using environment maps, e.g. simultaneous localisation and mapping [SLAM]
• G05D 1/248 - Arrangements for determining position or orientation using signals provided by artificial sources external to the vehicle, e.g. navigation beacons generated by satellites, e.g. GPS
• G05D 109/10 - Land vehicles
• G05D 111/10 - Optical signals
• G05D 111/50 - Internal signals, i.e. from sensors located in the vehicle, e.g. from compasses or angular sensors
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

The present disclosure relates to ICOS-L variants with enhanced binding affinity for ICOS. The ICOS-L variants of the present disclosure have significantly enhanced binding affinity for ICOS (˜approximately 100 times) compared to the wild-type ICOS-L and previous ICOS-L variants. With sizes considerably smaller than the large molecule IgG antibody, the variants easily penetrate the tumor microenvironment. It is straightforward to produce the variants, and their fusion with various immunotherapies makes applications as therapeutic agents and imaging molecules feasible. Therefore, the variants can be effectively utilized for cancer treatment and diagnosis.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present disclosure relates to anode for sodium ion batteries including hard carbon, and method of manufacturing the same. According to anode for sodium ion batteries including hard carbon, and method of manufacturing the same according to an embodiment of the present disclosure, it is possible to achieve improved reversible capacity and balanced electrochemical performance through an SPC factor, which is a structural index.

IPC Classes  ?

• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• C01B 32/324 - Preparation characterised by the starting materials from waste materials, e.g. tyres or spent sulfite pulp liquor
• C01B 32/348 - Metallic compounds
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium

Abstract

The present invention relates to a Bax fusion protein with a limited hydrophobic motif through optogenetic design and a composition for inhibiting apoptosis using the same. More specifically, the present invention relates to a Bax fusion protein to which an optogenetic protein that responds to light is bound, wherein the optogenetic protein is bound to an upper portion of the mitochondrial binding site of the Bax protein, and a composition for inhibiting apoptosis comprising the same. In the present invention, a Bax-Cry2 fusion protein n was confirmed to inhibit apoptosis when bound to TOMM20-Cib1, a mitochondrial membrane protein, by blue light. Therefore, it can be utilized as a composition for inhibiting apoptosis, and in particular, it can be applied to the treatment of degenerative neurological diseases through inhibition of apoptosis.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

According to various embodiments, an electronic device may: acquire a brokerage request for an advertisement contract from a first external device; in response to the brokerage request, acquire an advertisement model list including information on a plurality of advertisement models stored in a storage medium; acquire order information for the order of advertisement models to be requested for the advertisement contract; on the basis of the order information, transmit a first contract request including first contract information for a first advertisement model to a second external device, wherein the first contract request is activated for a first period; according to a designated condition being satisfied, transmit, on the basis of the order information, a second contract request including second contract information for a second advertisement model to a third external device, wherein the second contract request is activated for a second period including at least a part of a period overlapping with the first period; and according to acquisition of result data indicating conclusion of the advertisement contract from at least one of the second external device and the third external device, generate contract conclusion information indicating that the advertisement contract has been concluded. Various other embodiments identified through the specification are also possible.

IPC Classes  ?

• G06Q 30/02 - MarketingPrice estimation or determinationFundraising
• G06Q 30/06 - Buying, selling or leasing transactions

Abstract

Disclosed is a low Earth orbit satellite communication method and system using frequency-dependent beamforming. The low earth orbit satellite communication method using frequency-dependent beamforming includes: (a) forming frequency-dependent beamforming by adjusting at least one of a true time delay (TTD) and a phase shifter; and (b) searching a satellite or simultaneously providing a data service to multiple users by using the frequency-dependent beamforming, wherein the true time delay (TTD) is mandatory, while the phase shifter (PS) can be used optionally.

IPC Classes  ?

• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04L 43/0852 - Delays
• H04W 72/0453 - Resources in frequency domain, e.g. a carrier in FDMA

Abstract

An embodiment includes a forward data receiving device that demodulates and receives an Amplitude Shift Keying (ASK) modulation signal, and includes: an input module configured to receive the ASK modulation signal as an input; a resonance regulating rectifier module configured to regulate and rectify an input voltage of the ASK modulation signal on the basis of Pulse Width Modulation (PWM) according to a preset target voltage, and apply a regulated voltage through an output transistor; and a demodulation module configured to demodulate the ASK modulation signal according to a trend in a change of the input voltage compared to the regulated voltage, wherein the resonance regulating rectifier module includes a comparison unit configured to generate a gate signal for controlling on/off of the output transistor, and generate a sample signal for demodulating the ASK modulation signal.

IPC Classes  ?

• H03C 1/36 - Amplitude modulation by means of semiconductor device having at least three electrodes

Abstract

An optical element manufacturing apparatus is disclosed. The optical element manufacturing apparatus may comprise: a light source for generating light; a light modulation device which is provided with the light from the light source, and polarizes and diffracts the light to modulate the light so as to make a spatial change in the intensity of the light; a photoreactive polymer composition which is irradiated with the light modulated by the light modulation device; and a substrate which supports the photoreactive polymer composition.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements

Abstract

The present invention relates to a composition comprising an NNAT expression promoter or activity promoter as an active ingredient for preventing, alleviating, or treating Huntington's disease. The present disclosure also relates to various substances and a screening method therefor that can provide preventive or therapeutic effects on Huntington's disease by promoting the expression or activity of NNAT, which is reduced in expression and activity in patients with Huntington's disease.

IPC Classes  ?

• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

An ethylene partial pressure control device, according to one embodiment, may comprise: a first electrode part extending along one plane; a second electrode part extending along the one plane and disposed so as to be spaced apart from the first electrode part in one direction perpendicular to the one plane; a solid electrolyte membrane disposed between the first electrode part and the second electrode part; a power supply part for storing power generated between the first electrode part and the second electrode part, or supplying a predetermined power between the first electrode part and the second electrode part; and a processor for controlling the power supply part so as to, in a generation mode for generating ethylene or a removal mode for removing ethylene, store power generated between the first electrode part and the second electrode part, or apply power between the first electrode part and the second electrode part.

IPC Classes  ?

• A23B 7/152 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor in a controlled atmosphere comprising other gases in addition to CO2, N2, O2 or H2O
• F25D 17/04 - Arrangements for circulating cooling fluidsArrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection

Abstract

An ethylene partial pressure control device according to an embodiment may comprise: a first electrode unit extending along one plane; a second electrode unit extending along the one plane and disposed spaced apart from the first electrode unit along a direction perpendicular to the one plane; a solid electrolyte membrane disposed between the first electrode unit and the second electrode unit; a power supply unit for storing power generated between the first electrode unit and the second electrode unit; and a moisture transfer unit disposed between the first electrode unit and the second electrode unit and self-transferring moisture generated in the first electrode unit to the second electrode unit.

IPC Classes  ?

• A23B 7/152 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor in a controlled atmosphere comprising other gases in addition to CO2, N2, O2 or H2O
• F25D 17/04 - Arrangements for circulating cooling fluidsArrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection

Abstract

Proposed is an apparatus for separating CO2 gas captured with ammonia gas as an absorbent and the ammonia gas from a capture solution. The apparatus includes cation and anion exchange membranes spaced apart from each other to form a capture channel therebetween for a capture solution flow, cathode and anode current collector plates and their corresponding cation and anode exchange membranes forming cathode and anode channels therebetween, respectively. In the separate channels, basic and acidic solutions flow. Power applied to the collector plates drives ammonium and bicarbonate ions from the capture solution through the membranes, and then the ions convert into ammonia and CO2 gases in a chemical reaction, respectively. Through the power application with the basic and acidic solution flows through the corresponding channels, and a flow-conductive acid/base electrolytic separation method, gas separation without directly adding an acidic or basic solution to a capture solution is possible.

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01D 53/62 - Carbon oxides
• B01D 53/96 - Regeneration, reactivation or recycling of reactants

Abstract

This electronic device may comprise at least one processor and a memory that stores instructions. The electronic device may obtain a face parsing plane on the basis of a feature vector for a face region of an input image. Each of first pixels of the face parsing plane may represent a result of classifying each of second pixels of the face region into one of designated face regions. The electronic device may obtain spatial semantic attention through a projection operation between the face parsing plane and a correlation dictionary representing correlations between first words mapped to each of the face regions and second words mapped to each of the face attributes. The electronic device may determine at least one face attribute that the face region has among the face attributes on the basis of the spatial semantic attention.

IPC Classes  ?

• G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
• G06N 3/0499 - Feedforward networks
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

In one embodiment, a non-transitory computer-readable storage medium can store instructions. When executed by an electronic device including a memory, the instructions can cause the electronic device to: acquire, on the basis of reception of the query message from an external electronic device, a plurality of first tokens corresponding to a query message; use the plurality of first tokens and a persona database stored in the memory so as to generate a plurality of second tokens indicating a response message; when generating a third token indicating a word to be positioned after the plurality of second tokens in the response message, acquire a plurality of first candidate tokens by executing a language model; use the plurality of second tokens so as to search the persona database, thereby acquiring a plurality of second candidate tokens; determine the third token from among the plurality of first candidate tokens and the plurality of second candidate tokens; and transmit the response message including the plurality of second tokens and the third token to the external electronic device.

IPC Classes  ?

• G06F 16/332 - Query formulation
• G06F 16/338 - Presentation of query results
• G06F 16/31 - IndexingData structures thereforStorage structures
• G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates
• G06F 18/2413 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on distances to training or reference patterns
• G06F 18/2135 - Feature extraction, e.g. by transforming the feature spaceSummarisationMappings, e.g. subspace methods based on approximation criteria, e.g. principal component analysis
• H04L 51/02 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail using automatic reactions or user delegation, e.g. automatic replies or chatbot-generated messages
• H04L 51/04 - Real-time or near real-time messaging, e.g. instant messaging [IM]
• G06N 3/0475 - Generative networks
• G06N 3/096 - Transfer learning

Abstract

The present invention relates to a thin-film composite membrane for water treatment and a method for manufacturing same. The selective layer of the thin-film composite membrane according to the present invention is based on a cross-linked quaternary ammonium polymer with high hydrolysis resistance, and thus, excellent stability in both extremely acidic and alkaline conditions may be provided. In addition, the surface of the thin-film composite membrane according to the present invention is positively charged and thus can have high rejection and selectivity for cationic solutes.

IPC Classes  ?

• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 71/60 - Polyamines
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

The present invention relates to a hydrocarbon adsorbent with enhanced hydrothermal stability and a method for manufacturing the same by controlling the cation ratio within BEA zeolite. More specifically, the invention provides a hydrocarbon adsorbent in which the cation composition within the BEA zeolite structure is precisely controlled to enable effective adsorption and oxidation of hydrocarbons emitted during the cold-start period, thereby improving hydrothermal stability and maintaining structural integrity under harsh conditions. The hydrocarbon adsorbent according to the present invention exhibits improved hydrothermal stability and maintains excellent hydrocarbon adsorption and desorption performance even after undergoing high-temperature hydrothermal treatment in the presence of moisture.

IPC Classes  ?

• B01J 20/18 - Synthetic zeolitic molecular sieves
• B01D 53/06 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with moving adsorbents
• B01J 20/32 - Impregnating or coating

Abstract

A semiconductor device may include an active pattern on a substrate, a lower channel pattern on the active pattern and including first and second lower semiconductor patterns, an upper channel pattern on the lower channel pattern and including first and second upper semiconductor patterns, a pair of lower source/drain patterns on opposite sides of the lower channel pattern and a pair of upper source/drain patterns on opposite sides of the upper channel pattern, and a gate electrode surrounding the lower and upper channel patterns. The gate electrode may include a first upper portion between the first and second upper semiconductor patterns, and a first lower portion between the first and second lower semiconductor patterns. Each semiconductor pattern may include a first recess part having a first recess region on a top surface thereof, and a first protrusion part protruding from a bottom surface of the first recess part.

IPC Classes  ?

• H10D 84/85 - Complementary IGFETs, e.g. CMOS
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H10D 30/01 - Manufacture or treatment
• H10D 30/43 - FETs having zero-dimensional [0D], one-dimensional [1D] or two-dimensional [2D] charge carrier gas channels having 1D charge carrier gas channels, e.g. quantum wire FETs or transistors having 1D quantum-confined channels
• H10D 30/67 - Thin-film transistors [TFT]
• H10D 62/10 - Shapes, relative sizes or dispositions of the regions of the semiconductor bodiesShapes of the semiconductor bodies
• H10D 64/01 - Manufacture or treatment
• H10D 84/01 - Manufacture or treatment
• H10D 84/03 - Manufacture or treatment characterised by using material-based technologies using Group IV technology, e.g. silicon technology or silicon-carbide [SiC] technology
• H10D 88/00 - Three-dimensional [3D] integrated devices

Abstract

An interleukin-21 variant, a fusion protein containing the interleukin-21 variant and an antibody heavy chain constant region, and uses thereof are disclosed. The interleukin-21 variant has substitutions and/or deletions of some amino acids in wild-type interleukin-21. According to embodiments, a fusion protein in which the interleukin-21 variant is fused with an antibody (immunoglobulin) heavy chain constant region (Fc) pair containing a first Fc region and a second Fc region; uses of the interleukin-21 variant or the fusion protein for preventing or treating cancer; and a method for culturing immune cells using the interleukin-21 variant or the fusion protein are disclosed.

IPC Classes  ?

• C07K 14/54 - Interleukins [IL]
• A61K 38/20 - Interleukins
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present invention relates to a composition for treating pain diseases and, more specifically, provides: a liposomal complex comprising drug-encapsulated liposomes and poloxamer; and a pharmaceutical composition for treating pain diseases by nerve block, comprising same. The liposomal complex according to the present invention has a hydrophobic/hydrophilic drug encapsulated therein without crystal formation, and can remain at a target site in gel form in the body for a prolonged period, thereby significantly increasing the duration of action, and thus can enhance the efficiency and safety of the drug, and therefore, can be effectively applied to therapeutic fields for a wide range of spinal and pain-related diseases.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61P 41/00 - Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/1273 - PolymersomesLiposomes with polymerisable or polymerised bilayer-forming substances

Abstract

The present invention relates to a method and apparatus for bulk extraction and high-level purification of extracellular vesicles from biological samples. More specifically, in order to separate and extract the extracellular vesicles from large amount of culture medium, extracellular vesicles are adsorbed and extracted as same pass through a filter made of a porous medium surface-modified with a cationic substance. According to the present invention, exosomes or extracellular vesicles can be economically and efficiently separated and purified to a high level, and extracellular vesicles can be separated and purified in bulk. Therefore, the present invention is suitable for GMP and makes it possible to economically and efficiently separate and purify exosomes or extracellular vesicles of high purity and uniform particle size distribution at high yield.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/26 - Inoculator or sampler
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

The present invention provides a novel thiophene derivative, an optical isomer thereof, or a pharmaceutically acceptable salt thereof. A novel thiophene derivative according to the present invention has excellent inhibitory activity against KDM4, and thus is useful as a therapeutic agent for brain diseases such as Alzheimer's disease.

IPC Classes  ?

• C07D 333/38 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 409/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

The present invention relates to a quantum machine learning method for multi-class classification, and the method comprises the steps of: applying a Quantum Convolution Neural Network (QCNN) quantum circuit to input data having q qubits, and outputting a feature vector based on Pauli-Z measurement; and applying a Quantum Neural Network (QNN) quantum circuit to the feature vector, and outputting a multi-class prediction vector with scalability increased compared to q qubits based on basis measurement.

IPC Classes  ?

• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms

Abstract

The present invention relates to a technique of generating an optimal beamforming vector through a neural network model based on feature values that reflect distributed information of a base station constituting a Multiple Input Single Output Interference Channel (MISO IC) system.

IPC Classes  ?

• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

The present disclosure relates to a method for producing genetically modified cells, embryos, and animals on the basis of a CRISPR- virus-like particle (VLP) system. The method according to the present invention further simplifies and promotes the production of genetically modified animals without special techniques or equipment. As a result, modeling of animals, such as mice, can be made more easily and the present invention can be applied to various fields of research.

IPC Classes  ?

• A01K 67/0278 - Knock-in vertebrates, e.g. humanised vertebrates
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/873 - Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos

Abstract

The present invention relates to glycosylated FC variants of which binding affinity for human FcγRs is removed, to minimize off-target toxicity of an antibody against an antigen. Novel human antibody Fc domain variants of the present invention, which were discovered using Chinese hamster ovary (CHO) cells having a very similar sugar profile to humans, have significantly reduced binding to Fc gamma receptors, compared to wild-type human antibody Fc domain and conventional S228P or S228P/L235E variants, and are variants of which pH-dependent binding affinity for FcRn and thermal stability are maintained and binding affinity for all FcγRs is completely removed. Therefore, the variants can be used to reduce the toxicity and enhance the efficacy of therapeutic protein drugs and to maintain the half-life of diagnostic/research substances and remove target toxicity.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

The present invention relates to: a biomarker composition capable of determining whether an individual having an allergic disease is exposed to heavy metals in the air; a kit comprising an agent capable of detecting the biomarker; and the like. More specifically, the biomarker composition and the like of the invention is achieved by identifying genes of which the expression increases when an individual having an allergic disease is exposed to heavy metals.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

A method for delaying frost sticking of a heat exchanger containing a hydrogel coating layer according to the present invention includes: absorbing moisture by means of the hydrogel coating layer; forming slurry ice inside the hydrogel coating layer that has absorbed the moisture; and regenerating the hydrogel coating layer when the formed slurry ice occupies 50% or more of the total area of the hydrogel coating layer.

IPC Classes  ?

• F28F 19/04 - Preventing the formation of deposits or corrosion, e.g. by using filters by using coatings, e.g. vitreous or enamel coatings of rubberPreventing the formation of deposits or corrosion, e.g. by using filters by using coatings, e.g. vitreous or enamel coatings of plastics materialPreventing the formation of deposits or corrosion, e.g. by using filters by using coatings, e.g. vitreous or enamel coatings of varnish
• F28F 19/00 - Preventing the formation of deposits or corrosion, e.g. by using filters
• F28F 1/24 - Tubular elements or assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with projections, with recesses the means being only outside the tubular element and extending transversely
• C09D 5/00 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects producedFilling pastes
• C09D 4/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
• C09D 7/65 - Additives macromolecular
• C09J 183/06 - Polysiloxanes containing silicon bound to oxygen-containing groups

Abstract

Disclosed herein is a pharmaceutical composition for preventing or treating endometriosis, comprising fraxetin. When used as a pharmaceutical composition for preventing or treating endometriosis and complications associated therewith, with fraxetin or a pharmaceutically acceptable salt thereof as an active ingredient, the present disclosure offers effective management of endometriosis with fewer side effects compared to surgery and hormone therapy and thus can be advantageously used as a therapeutic agent for endometriosis and complications associated therewith.

IPC Classes  ?

• A61K 31/37 - Coumarins, e.g. psoralen
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• A61P 15/00 - Drugs for genital or sexual disordersContraceptives

Abstract

The present invention relates to a biomarker composition capable of determining whether an individual with an allergic disease is exposed to fine dust in the air, and to a kit comprising a preparation capable of detecting the biomarker. More specifically, the present invention relates to the identification of a gene of which the expression increases when an individual with an allergic disease is exposed to fine dust, thereby enabling the development of the biomarker composition and the like.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The feedback field-effect transistor-based ring oscillator includes a plurality of feedback field-effect transistors each in which a diode structure is present as an n-type doped channel region and a p-type doped channel region between a drain terminal and a source terminal, a gate terminal is present in the diode structure, wherein the plurality of feedback field-effect transistors operates as p-channel mode when the gate terminal is present on the n-type doped channel region and operates as n-channel mode when the gate terminal is present on the p-type doped channel region, and in a plurality of inverters formed by the plurality of feedback field-effect transistor, an output terminal of an inverter of each stage is input to an input terminal of a next stage and an oscillation operation is performed based on supply voltage applied through the drain terminal and the source terminal.

IPC Classes  ?

• H03K 3/03 - Astable circuits

Abstract

A method for controlling an autonomous driving of a vehicle is introduced. The method may comprise generating a weighted adjacency matrix from an object graph, based on a location relative to an anticipated collision point among objects. The method may further comprise, based on this matrix and a graph convolution layer of a high-order graph model, generating an Mth-order adjacency matrix, defining interrelations among objects across M number of hops, generating object attribute information from this matrix and feature information defining an attribute of an object, generating, based on a combination layer of the high-order graph model, cumulative feature information by integrating the object attribute information, embedding the cumulative feature information into the object graph, generating, based on the embedding and a predicted path model, an object's predicted path, and outputting, based on this predicted path, a signal for controlling the autonomous driving of the vehicle.

IPC Classes  ?

• B60W 30/09 - Taking automatic action to avoid collision, e.g. braking and steering
• B60W 30/095 - Predicting travel path or likelihood of collision
• B60W 50/00 - Details of control systems for road vehicle drive control not related to the control of a particular sub-unit
• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

Disclosed is a hybrid comparator circuit device. The hybrid comparator circuit device includes: a first mode operation circuit unit detecting a first point where a first reference signal VREG is the same as a low AC input signal by receiving the low AC input signal VINN; a second mode operation circuit unit detecting a second point where a second reference signal VREG is the same as a high AC input signal by receiving the high AC input signal VINN; and a MUX M1 outputting a detection result of any one of the first mode operation circuit unit and the second mode operation circuit unit, wherein any one of the first mode operation circuit unit and the second mode operation circuit unit may operate or both may not operate.

IPC Classes  ?

• H03K 5/24 - Circuits having more than one input and one output for comparing pulses or pulse trains with each other according to input signal characteristics, e.g. slope, integral the characteristic being amplitude
• H02M 1/00 - Details of apparatus for conversion

Abstract

The present disclosure relates to a high performance molecular thermoelectric device using an organometallic molecular chain capable of coherent near-resonant tunneling, and relates to a method of forming an organometallic molecular chain capable of coherent near-resonant tunneling on an electrode surface using an electrochemical reduction grafting method, a thermoelectric assembly (molecular junction) using the same, a high performance molecular thermoelectric device and investigating thermoelectric properties.

IPC Classes  ?

• H10N 10/856 - Thermoelectric active materials comprising organic compositions
• H10N 10/01 - Manufacture or treatment
• H10N 10/82 - Interconnections

Abstract

The present disclosure relates to a method for screening drugs for treating multiple-variant coronavirus disease. The present disclosure provides a method for screening coronavirus therapeutic agents in a short period of time by using a low concentration of Mpro.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

Abstract

Provided is an Fc variant which has improved half-life by binding to and unbinding from FcRn in a pH-dependent manner, and which has improved selective binding to Fcγ receptors. Compared to a wild-type human antibody Fc domain and conventional antibodies approved as antibody therapeutic agents, the present human antibody Fc domain variants have a lower capacity to bind to immune-inhibiting receptors FcγRIIb and FcγRIIIb and have a higher capacity to bind to immune-activating receptor FcγRIIa (increased A/I ratio), thereby having a remarkably improved effector function and having maximized half-life in blood in which excellent pH-selective FcRn binding and unbinding capacity is exhibited, and thus bind to numerous peptide drug therapeutics having short half-life and retention time in the body so that long-term drug efficacy through increased blood half-life can be exhibited, and can maximize the immune mechanism of therapeutic protein drugs.

IPC Classes  ?

• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed is a superhydrophobic film. The superhydrophobic film includes: a base film; and a plurality of micro-pillars formed on the base film, wherein the base film and the micro-pillar include a biodegradable polymer and nanoparticles.

IPC Classes  ?

• H10H 29/853 - Encapsulations characterised by their shape
• H10H 29/854 - Encapsulations characterised by their material, e.g. epoxy or silicone resins

Abstract

Disclosed is a binarized neural network circuitry using a quasi-nonvolatile memory device. More particularly, the binarized neural network circuitry according to an embodiment of the present disclosure is characterized in that a diode structure is positioned in a channel region between a drain terminal and a source terminal, a gate terminal is positioned on the diode structure, an operation state is determined by occurrence of a latch-up or latch-down phenomenon due to a positive feedback loop in the channel region based on different voltages applied to the drain terminal and the gate terminal, respectively, and a plurality of quasi-nonvolatile memory devices that implement memory characteristics of remembering a memory state are included as holes or electrons in a potential well in the channel region due to the positive feedback loop are accumulated, and the plural quasi-nonvolatile memory devices are a pair of two quasi-nonvolatile memory devices that operate as a single synaptic cell and are connected in parallel to form an array circuit, memory states of the two quasi-nonvolatile memory devices are determined and stored based on an input line applied from an input line processor connected to the array circuit and a weight update signal applied from a synaptic line processor connected to the array circuit, and a MAC (multiply-accumulate) operation result is output using a combination of the memory states.

IPC Classes  ?

• G06N 3/065 - Analogue means

Abstract

The present invention relates to a biomarker for predicting the reoccurrence or prognosis of diabetic foot ulcer, according to specific methylation of at least one gene selected from the group consisting of MORN1, NCOR2, and LINC00504. The present invention identifies a specific pattern of reoccurrence or prognosis of diabetic foot ulcer, discovers major biomarkers that account for the pattern, by machine learning of gene data, and thus, not only can predict the reoccurrence or prognosis of diabetic foot ulcer by using blood analysis-based clinical biomarkers, and but can also be used in the future to develop mechanisms for preventing or treating diabetic foot ulcer. By the discovery of factors that account for vital signs, the prediction of treatment or prognosis of diabetic foot ulcer is possible, and thus, a system capable of preemptively controlling disease progress can be established.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

The present invention relates to a method of converting human fibroblasts into neural stem cells, and more particularly, to a conversion method through direct cross-differentiation of human fibroblasts into neural stem cells using a combination of Sendai virus, mRNA or miRNA of a stem cell-related factor, and a small molecule compound, and a use thereof. According to the present invention, since high-quality neural stem cells may be induced from human fibroblasts through direct cross-differentiation within a short period of time, it is possible to secure a sufficient amount of cells for cell therapy, and since there is no side effect of tumorigenesis, the present invention may be used as a cell therapeutic agent for brain diseases.

IPC Classes  ?

• C12N 5/0797 - Stem cellsProgenitor cells
• A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue

Abstract

The present invention relates to a rehabilitation assistive device utilizing wireless electrical stimulation based on a high-frequency induction coil and conductive hydrogel. Specifically, the present invention concerns a nerve regeneration device using wireless electrical stimulation, which is based on the phenomenon where current is induced within the conductive hydrogel by the electromagnetic waves generated from a coil carrying high-frequency alternating current. The present invention can be applied as a nerve regeneration-promoting system, wherein conductive hydrogel is injected into the damaged area of the subject's nerve tissue using the wireless electrical stimulation device, thereby aiding in nerve regeneration.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61L 31/04 - Macromolecular materials
• A61N 1/40 - Applying electric fields by inductive or capacitive coupling

Abstract

A method for manufacturing a carbon dioxide adsorbent, according to the idea of the present disclosure, comprises the steps of: obtaining an oxide-carbon nanomaterial composite by mixing a carbon nanomaterial solution and an oxide nanoparticle solution; obtaining an oxide-carbon nanomaterial composite having an amine group introduced thereto by supporting an amine group on the oxide-carbon nanomaterial composite; and coating the surface of a substrate with the oxide-carbon nanomaterial composite having the amine group introduced thereto using a cold spray method to produce a carbon dioxide adsorbent.

IPC Classes  ?

• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
• B01J 20/08 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising aluminium oxide or hydroxideSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising bauxite
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01J 20/32 - Impregnating or coating
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography

Abstract

A home appliance disclosed herein comprises: a heat exchanger; a hydrogel coated on the surface of the heat exchanger; a compressor for supplying a refrigerant to the heat exchanger; a first pressure sensor for detecting a first pressure of the refrigerant flowing into the heat exchanger; a second pressure sensor for detecting a second pressure of the refrigerant discharged from the heat exchanger; and a control unit which calculates an average pressure of the refrigerant on the basis of the first pressure of the refrigerant and the second pressure of the refrigerant, determines a surface temperature of the heat exchanger corresponding to the average pressure of the refrigerant, and controls the compressor so that the surface temperature of the heat exchanger is maintained at a target temperature in order to thaw the hydrogel during a defrosting operation.

IPC Classes  ?

• F25B 47/02 - Defrosting cycles
• F25B 49/02 - Arrangement or mounting of control or safety devices for compression type machines, plants or systems
• F25D 21/00 - DefrostingPreventing frostingRemoving condensed or defrost water
• F25D 21/08 - Removing frost by electric heating
• F24F 13/22 - Means for preventing condensation or evacuating condensate
• F28F 17/00 - Removing ice or water from heat-exchange apparatus

Abstract

A hardware accelerator includes a multiply-accumulate (MAC) array, the MAC array including a plurality of arrays, and a global multiplexer logic configured to connect or disconnect at least two of the plurality of arrays, based on a first control signal. Each of the plurality of arrays includes a plurality of sub-arrays including a plurality of first sub-arrays and a second sub-array, and a local multiplexer logic configured to connect or disconnect the plurality of sub-arrays, based on a second control signal.

IPC Classes  ?

• G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
• G06F 7/499 - Denomination or exception handling, e.g. rounding or overflow

Abstract

Disclosed herein is a single-input multi-output resonant regulating rectifier. The single-input multi-output resonant regulating rectifier may include: a conversion circuit unit converting a wireless power alternating current (AC) signal into half-cycle input signals VINN and VINP; and an output generation circuit unit generating a plurality of outputs within a half cycle by generating a plurality of gate signals in a plurality of different regions within each half cycle based on the half-cycle input signal VINN input through the conversion circuit unit.

IPC Classes  ?

• H02M 7/23 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only arranged for operation in parallel
• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters
• H02M 1/14 - Arrangements for reducing ripples from DC input or output

Abstract

An electronic device includes a multiplier including a multiplication logic, a memory including at least one instruction, and at least one processor configured to execute the at least one instruction and to obtain a first input value and a second input value, identify datatypes and precisions of the first input value and the second input value, based on the identified datatypes and precisions, distribute bits of the first input value and bits of the second input value to sub-multiplication logics of the multiplication logic, and obtain at least one output of the multiplication logic based on outputs of the sub-multiplication logics.

IPC Classes  ?

• G06F 7/523 - Multiplying only

Abstract

The present invention relates to a vascular clip for blood flow control, wherein the vascular clip is based on a shape-memory polymer and serves to partially occlude a vessel through which excessive blood flow passes due to the incomplete automatic regulatory function thereof so as to induce normal blood flow and release the occlusion when the automatic regulatory function recovers, the occlusion is released, whereby when applied as a device to substitute for the lost automatic regulatory function of the vessel, the vascular clip can prevent cerebral hyperperfusion syndrome in advance, thus solving problems caused by the syndrome and can eliminate the risks of removal surgery, thus providing safety and convenience for patients.

IPC Classes  ?

• A61B 17/122 - Clamps or clips, e.g. for the umbilical cord
• A61B 17/00 - Surgical instruments, devices or methods
• A61L 31/14 - Materials characterised by their function or physical properties

Abstract

Proposed is a mobile robot capable of learning risk-aware traversability via accumulated navigation experience. The mobile robot includes a point cloud sensor which acquires point cloud data, an elevation map generation part which generates a grid-based elevation map by using the point cloud data, an attribute data generation part which calculates a plurality of types of terrain attribute values for each of grid cells from the elevation map and generates attribute data sets having the plurality of types of terrain attribute values for each of the grid cells, a training data generation part which generates a plurality of traversability training data sets and a plurality of non-traversability training data sets by labeling whether each of the attribute data sets is in traversable condition, a risk calculation part which calculates a traversal risk, and a risk-aware self-training part which trains a traversability evaluation model for traversability evaluation through self-training.

IPC Classes  ?

• G05D 1/617 - Safety or protection, e.g. defining protection zones around obstacles or avoiding hazards
• G05D 1/246 - Arrangements for determining position or orientation using environment maps, e.g. simultaneous localisation and mapping [SLAM]
• G05D 101/15 - Details of software or hardware architectures used for the control of position using artificial intelligence [AI] techniques using machine learning, e.g. neural networks
• G05D 111/10 - Optical signals

Abstract

Disclosed is a thermal management structure of a battery cell, the thermal management structure including: a plurality of battery cells repeatedly arranged; a cell cooler connected to one side of each of the battery cells to enable heat transfer, and configured to cool the battery cell or raise the temperature of the battery when necessary; and a hybrid phase change material (PCM) part respectively disposed between the battery cells to absorb heat generated from the battery cells, and formed of different types of phase change materials (PCMs) respectively disposed in a plurality of divided regions divided in a shape of corresponding to a temperature gradient pattern of the battery cells.

IPC Classes  ?

• H01M 10/659 - Means for temperature control structurally associated with the cells by heat storage or buffering, e.g. heat capacity or liquid-solid phase changes or transition
• H01M 10/613 - Cooling or keeping cold
• H01M 10/647 - Prismatic or flat cells, e.g. pouch cells
• H01M 10/6551 - Surfaces specially adapted for heat dissipation or radiation, e.g. fins or coatings
• H01M 50/211 - Racks, modules or packs for multiple batteries or multiple cells characterised by their shape adapted for pouch cells

Abstract

The present invention relates to a spacing-adjustable bone orthopedic apparatus. The apparatus may include a plate including a main body and a through portion having a predetermined length and formed to pass through the main body and a locking screw which is inserted into the through portion, which includes a screw body and a screw head which are capable of being coupled to each other, and in which outer circumferential surface saw teeth are formed on an outer circumferential surface of the screw head.

IPC Classes  ?

• A61B 17/80 - Cortical plates
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/68 - Internal fixation devices
• A61B 17/86 - Pins or screws

Abstract

The present disclosure relates to an electronic device and a method for generating dental data information, and the method for generating dental data information, according to an embodiment of the present disclosure, may comprise the steps of: acquiring input information including X-ray image information of a patient from a first terminal; inferring tooth information according to the dental formula of the patient on the basis of the input information through a first artificial intelligence model; and generating the dental data information on the basis of the tooth information according to the dental formula through a second artificial intelligence model.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 70/00 - ICT specially adapted for the handling or processing of medical references
• A61B 6/51 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications for dentistry
• G06N 20/00 - Machine learning
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The present invention relates to a parallel drug screening method using ID-microparticles bound to a target. The present invention enables multiple target screening for a specific disease and thus has an advantage whereby costs and time may be saved as much as the number of target types compared to the existing DEL method. In addition, whereas the existing DEL method has a limitation in that a target is fixed to a surface of a solid support, thereby resulting in structural change and a specific direction being hidden, a target encapsulated in a hydrogel or bound to the hydrogel in a random direction may overcome such limitation.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• C12Q 1/6841 - In situ hybridisation

Abstract

Provided is a composition for cancer diagnosis targeting a tumor and/or tumor microenvironment and a use thereof, and more specifically, a fluorescent contrast agent composition targeting biomolecules overexpressed in cancer cells and tumor microenvironment. According to the present disclosure, it is possible to provide a fluorescent contrast agent that may simultaneously target cancer (folate receptor alpha-expressing cancer) cells and tumor-associated macrophages in the tumor microenvironment.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/7004 - Monosaccharides having only carbon, hydrogen and oxygen atoms
• A61K 49/00 - Preparations for testing in vivo
• C07D 209/04 - IndolesHydrogenated indoles
• C07D 475/00 - Heterocyclic compounds containing pteridine ring systems
• C07H 3/02 - Monosaccharides

Abstract

The present invention relates to a high-entropy oxide catalyst for increasing the efficiency of electrochemical methane conversion and a method for alcohol production using same.

IPC Classes  ?

• B01J 23/889 - Manganese, technetium or rhenium
• B01J 35/45 - Nanoparticles
• B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
• B01J 23/70 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper
• C07C 31/08 - Ethanol

Abstract

A semiconductor substrate of the present invention may comprise a substrate and a semiconductor layer disposed on the substrate. The semiconductor layer can be deposited by supplying additional energy to any one of CVD, ALD, and sputtering methods during a thin film growth process step. The additional energy can be at least one from among plasma, a laser, and an LED light source. For example, the substrate can be a glass substrate, and the semiconductor layer can be a nitride semiconductor layer having a single-crystal surface. The semiconductor layer can be deposited by increasing kinetic energy of a source or a target that deposits the semiconductor layer with the additional energy.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/26 - Bombardment with wave or particle radiation
• C23C 14/00 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
• C23C 14/06 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

The present invention relates to a hydrogel in which a DNA barcode is replicated at high resolution and high density. The hydrogel of the present invention provides, first, a method by means of which gene expression levels can be easily, at high resolution, and further at a relatively low cost, analyzed while maintaining positional information within tissue of cells. Second, high capture efficiency at high resolution can be achieved at low cost for analysis of mRNA or the like. Third, since the hydrogel is formed in a three-dimensional structure, a barcode is generated at high density, thereby enabling achievement of various effects such as achieving high capture efficiency.

IPC Classes  ?

• C12Q 1/6813 - Hybridisation assays
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

A camera tracking apparatus for supporting segmentation based on a building information modeling (BIM) in an indoor environment receives a red/green/blue (RGB) image and a depth map including a pillar photographed by a red/green/blue-depth (RGB-D) camera, detects an RGB edge and a depth edge of a pillar using the RGB image and the depth map, calculates both end points and removes an outlier from a result of combining the RGB edge and the depth edge and detects a scene edge corresponding to the pillar, searches for a BIM edge corresponding to the scene edge using the scene edge, detects a scene face of a floor and the pillar using a face detection algorithm, searches for a BIM face corresponding to the scene face using a center point of the scene face, and removes an incorrect matching result.

IPC Classes  ?

• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06T 7/13 - Edge detection
• G06V 20/20 - ScenesScene-specific elements in augmented reality scenes

Abstract

The present invention relates to a reconfigurable logic-in-memory cell consisting of triple-gate feedback memory elements. The reconfigurable logic-in-memory cell according to one embodiment of the present invention includes a plurality of triple-gate feedback memory elements including a drain region, a channel region, a source region, and a gate region where first and second programming gate electrodes and a control gate electrode are formed on the channel region.

IPC Classes  ?

• H10B 12/00 - Dynamic random access memory [DRAM] devices
• G11C 11/404 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells with charge regeneration common to a multiplicity of memory cells, i.e. external refresh with one charge-transfer gate, e.g. MOS transistor, per cell
• H03K 19/177 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits using specified components using elementary logic circuits as components arranged in matrix form

Abstract

The present invention relates to a distributed optimization technique for learning a neural network model based on a distributed learning framework embedded in each node, for each node constituting a hierarchical tree-structured network.

IPC Classes  ?

• G06N 3/096 - Transfer learning
• G06N 3/045 - Combinations of networks

Abstract

A learning-based semantic segmentation method and apparatus for semiconductor metrology are disclosed. The method includes performing, using a processor, a pre-training stage to determine initial weights among nodes within a neural network model by pre-training the neural network for process-specific semantic segmentation; and performing, using a processor, a fine-tuning stage to classify an input wafer TEM or SEM image into at least one object of interest based on pre-trained weights, and to assign a weight (α) greater than one ( ) to pixels corresponding to boundaries separating the objects of interest and a weight one (1) to other pixels corresponding to regions distinct from the boundaries using a loss function (LBF).

IPC Classes  ?

• G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/34 - Smoothing or thinning of the patternMorphological operationsSkeletonisation
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

Data augmentation methods and apparatus for machine learning, and utilization thereof, are disclosed. A computer-implemented method for data augmentation in electron microscope imaging, the method comprising: receiving, using a processor, an input image captured by an electron microscope; processing, using a processor, the input image to generate an augmented image dataset, the processing comprising: generating a first transformed image by converting an interior region of an object region of interest in the input image to a single color; generating a second transformed image by converting a region other than the object region of interest in the input image to a single color; and generating a third transformed image by modifying pixel positions exclusively within the interior region of the object region of interest in the input image; and outputting the augmented image dataset to train a machine learning model.

IPC Classes  ?

• G06T 11/60 - Editing figures and textCombining figures or text
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• H04N 1/40 - Picture signal circuits

Abstract

The present invention relates to a zeolite separation membrane reactor for dehydrogenation of a liquid organic hydrogen carrier. According to the present invention, it is possible to provide a zeolite separation membrane reactor for dehydrogenation of a liquid organic hydrogen carrier, which overcomes the thermodynamic limit of a dehydrogenation reaction by using a zeolite separation membrane reactor filled with a catalyst therein and achieves a conversion rate higher than an equilibrium conversion rate at a low reaction temperature, thereby having high hydrogen separation performance.

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 71/02 - Inorganic material
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties

Abstract

A security vulnerability propagation detection apparatus according to an embodiment may perform the operations of: obtaining version information of target software and open-source software used in the target software; classifying functions included in the version of open-source software into a first function used identically in the target software, a second function modified and used, and a third function not used; determining whether the second function has been patched, based on a first similarity between the second function and an original function of the version and a second similarity between the second function and a patch function of the version; and detecting a vulnerability propagated to the target software from vulnerabilities inherent in the version of open-source software, based on the classification of the first function, the second function, and the third function, and the patch status of the second function.

IPC Classes  ?

• G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
• G06F 21/54 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by adding security routines or objects to programs

Abstract

The present disclosure relates to a fine-tuning apparatus for neural architecture search (NAS), the apparatus including an architecture fine-tuning unit that samples candidate architectures for target data from a search space having a plurality of SubNets and searches for an optimal architecture for the target data based on the candidate architectures; and a weight fine-tuning unit that tunes a pre-trained weight of the optimal architecture to match the target data.

IPC Classes  ?

• G06N 3/092 - Reinforcement learning

Abstract

The present invention relates to the production of a protease-based protein biosensor capable of specifically quantifying methionine sulfoxide present in a target protein and use thereof, and more specifically, to: a recombinant protein for a fluorescent biosensor for quantifying methionine sulfoxide present in a target protein, the recombinant protein comprising a fluorescent protein, a methionine sulfoxide reductase (Msr) protein, an enterokinase cleavage site, a thioredoxin protein, and protein G; a biosensor comprising same; and a method for quantifying methionine sulfoxide in a target protein using same. The biosensor according to the present invention can accurately measure in a quantitative manner the degree of oxidation of methionine residues in a specific protein rather than all proteins through the detection of specific fluorescence changes, and thus can be used as a fluorescent biosensor for diagnosing oxidative stress diseases. Moreover, the biosensor can recognize the degree of aging through the measurement of the degree of oxidation, and thus can be effectively used for diagnosing aging and related diseases.

IPC Classes  ?

• G01N 33/535 - Production of labelled immunochemicals with enzyme label
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label

Abstract

The present invention relates to a composition for treating neurodegenerative diseases, comprising a whey protein hydrolysate or a whey protein hydrolysate-derived peptide. A peptide consisting of the amino acid sequence represented by SEQ ID NO: 1 or a whey protein hydrolysate comprising same, of the present invention, can be used to effectively prevent, treat and ameliorate neurodegenerative diseases.

IPC Classes  ?

• C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A23J 1/20 - Obtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites from milk, e.g. caseinObtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites from whey

Abstract

Disclosed is a spin-orbit torque (SOT)-based magnetic tunnel junction, including: a spin-orbit torque active layer formed on a substrate; a magnetization-free layer formed on the spin-orbit torque active layer; a tunnel barrier layer formed on the magnetization-free layer; and a magnetization-pinned layer formed on the tunnel barrier layer, wherein the spin-orbit torque active layer is a W-X alloy (where W is tungsten, and X includes at least one of group IV semiconductors and group III-V semiconductors).

IPC Classes  ?

• H10N 50/85 - Materials of the active region
• C22C 27/04 - Alloys based on tungsten or molybdenum
• H01F 10/32 - Spin-exchange-coupled multilayers, e.g. nanostructured superlattices
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices

Abstract

According to an embodiment of the present disclosure, there is provided a marker composition for diagnosing cancer or predicting prognosis, comprising exosomes overexpressing a Tubulin alpha-1C chain (TUBA1C) protein.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present specification discloses an apparatus and method for generating symptom occurrence prediction information. The apparatus for generating symptom occurrence prediction information, according to the present specification, may include: a transmitting and receiving unit that receives, from a digital device, demographic information, psychological test scales, biometric information, and daily information of a patient and transmits, to the digital device, prediction information and feedback information about whether a panic symptom has occurred; a pattern information generation unit for generating information related to a pattern change of the biometric information (hereinafter, referred to as "pattern information"); a prediction information generation unit for generating the prediction information by using the demographic information, the psychological test scales, the pattern information, and the daily information of the patient; and a feedback generation unit for generating the feedback information according to the prediction information.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A slot die coater includes a slot die configured to include a first slot through which a first active material is dispensed, a second slot through which a second active material is dispensed, and a third slot through which a third active material is dispensed; and a first spacer, a second spacer, and a third spacer inserted into the first, second, and third slots, respectively, wherein the first, second, and third slots are sequentially aligned in a direction of travel in which a substrate moves to form an active material coating layer having a multilayer in which the active materials dispensed through the first, second, and third spacers are stacked.

IPC Classes  ?

• B05C 5/02 - Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work from an outlet device in contact, or almost in contact, with the work
• H01M 4/04 - Processes of manufacture in general
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx

Abstract

The present invention relates to a spring-type insertion device for preventing recurrence after discectomy, and may comprise: a first insertion element that is connected to an upper or lower vertebral body and has a first base plate fixed on one surface of the vertebral body and an elastic member extending toward the other vertebral body facing away from the first base plate; and a second insertion element that is connected to the other vertebral body to which the first insertion element is not connected and has a second base plate fixed on one surface of the other vertebral body and a protrusion extending toward the vertebral body facing away from the second base plate.

IPC Classes  ?

• A61F 2/44 - Joints for the spine, e.g. vertebrae, spinal discs

Abstract

The present invention relates to a Janus separator for a lithium metal secondary battery, a method for manufacturing same, and a lithium metal secondary battery comprising same, the Janus separator comprising: a separator; and a carbon nanotube assembly coated on one surface of the separator and containing an amine group-containing linker and carbon nanotubes surface-modified with a carboxyl group.

IPC Classes  ?

• H01M 50/431 - Inorganic material
• H01M 50/443 - Particulate material
• H01M 50/417 - Polyolefins
• H01M 50/457 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising three or more layers
• H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms
• H01M 10/052 - Li-accumulators
• H01M 50/411 - Organic material

Abstract

Provided are a resist composition for photolithography and a method for manufacturing a semiconductor device using the same. The method for manufacturing a semiconductor device includes forming a photoresist film on a substrate, performing a first exposure process and a development process on the photoresist film to form photoresist patterns, and performing a second exposure process on the photoresist patterns. The photoresist film includes a polymer containing a repeating unit having an azobenzene group or a metal oxide nanocluster having an azobenzene group. The performing of the second exposure process includes controlling an orientation of the azobenzene group within the photoresist patterns according to a polarization direction of incident light.

IPC Classes  ?

• G03F 7/004 - Photosensitive materials
• C08F 120/36 - Esters containing nitrogen containing oxygen in addition to the carboxy oxygen
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G03F 7/20 - ExposureApparatus therefor

Abstract

The present application relates to an anastomosis device having a new arrangement for improving the end-to-end anastomosis of the intestines, the device comprising: an anvil head having an anvil inserted into a proximal intestine, and an anvil shaft extending from the anvil to one side; and a stapler having, at the front end portion thereof, a trocar forming an anvil-coupling with the anvil shaft, wherein the trocar is inserted into the anvil shaft from the side surface of the anvil shaft so that the anvil-coupling can be formed.

IPC Classes  ?

• A61B 17/115 - Staplers for performing anastomosis, e.g. in a single operation
• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

The present invention relates to a novel fusion protein of albumin and retinol-binding protein, which can be used for preventing or treating fibrotic diseases occurring in the liver, pancreas, lungs, and the like. The fusion protein of the present invention can prevent or treat fibrotic diseases by inhibiting activation of stellate cells that cause tissue fibrosis or by inducing reversion of the activated state.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/76 - Albumins
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention relates to an infrared optical device and a manufacturing method therefor, the infrared optical device comprising: a substrate; an electron transport layer; a first silver telluride quantum dot nanocrystalline layer having halogen atom ligands bonded thereto; a second silver telluride quantum dot nanocrystalline layer having thiol-based organic ligands bonded thereto; a hole transport layer; and a metal electrode, wherein these elements are sequentially stacked.

IPC Classes  ?

• G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
• C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C09K 11/88 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
• H10K 30/60 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation in which radiation controls flow of current through the devices, e.g. photoresistors
• H10K 30/85 - Layers having high electron mobility, e.g. electron-transporting layers or hole-blocking layers
• H10K 30/86 - Layers having high hole mobility, e.g. hole-transporting layers or electron-blocking layers
• H10K 30/81 - Electrodes
• H10K 30/35 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising bulk heterojunctions, e.g. interpenetrating networks of donor and acceptor material domains comprising inorganic nanostructures, e.g. CdSe nanoparticles
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating

Abstract

The present invention relates to a composition for cancer diagnosis targeting a tumor and/or a tumor microenvironment and use thereof and, more specifically, provides a fluorescent contrast agent composition targeting biomolecules overexpressed in cancer cells and a tumor microenvironment. According to the present invention, a fluorescent contrast agent capable of targeting both cancer (folate receptor alpha-expressing cancer) cells and tumor-related macrophages in a tumor microenvironment can be provided.

IPC Classes  ?

• C07D 209/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61K 49/00 - Preparations for testing in vivo
• C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
• C07D 475/02 - Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

Abstract

The present invention relates to a cell adhesion and migration regulation platform using an integrin-mediated single-molecule binding force probe. The cell adhesion and migration regulation platform according to an embodiment of the present invention includes: a substrate (10); a binding layer (20) formed on the surface of the substrate (10); a single-molecule force probe (30), which has a predetermined binding force, is adhered to the cell by selectively binding to integrins in the cell membrane, and is ruptured when an external force applied by the cell exceeds the binding force; and a linker part (40) for connecting the binding layer (20) and the single-molecule force probe (30).

IPC Classes  ?

• C12N 5/07 - Animal cells or tissues

Abstract

An oxide semiconductor transistor, a method for manufacturing the same, and a semiconductor device including the oxide semiconductor transistor are disclosed. The disclosed oxide semiconductor transistor may include a gate electrode, a p-type oxide semiconductor channel layer disposed opposite the gate electrode, a gate insulating layer between the gate electrode and the oxide semiconductor channel layer, a source electrode and a drain electrode electrically connected to a first region and a second region of the oxide semiconductor channel layer, respectively, and an intermediate layer disposed between the oxide semiconductor channel layer and the source electrode, as well as between the oxide semiconductor channel layer and the drain electrode, the intermediate layer having an oxygen areal density (OAD) higher than an OAD of the oxide semiconductor channel layer.

IPC Classes  ?

• H10D 62/60 - Impurity distributions or concentrations
• H10D 30/01 - Manufacture or treatment
• H10D 30/67 - Thin-film transistors [TFT]
• H10D 62/80 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials

Abstract

An anode electrode for organic light emission diode (OLED) outcoupling and an organic light emission diode (OLED) including the same are disclosed. The anode electrode for OLED outcoupling includes: a top anode layer; a bottom anode layer positioned below the top anode layer; and an interlayer positioned between the top anode layer and the bottom anode layer, and made of a material having a different dielectric constant depending on a material constituting the top anode layer and the bottom anode layer.

IPC Classes  ?

• H10K 50/816 - Multilayers, e.g. transparent multilayers
• H10K 50/813 - Anodes characterised by their shape

Abstract

An apparatus and a method for controlling a pharmaceutical mixer of a medication for Attention Deficit Hyperactivity Disorder (ADHD) based on an assessment of a mental health state of an adolescent. The method comprises: collecting physical information of a user; verifying survey questions regarding mental health depending on the physical information and real-time brain activity data; forming additional survey questions after having verified the answers and calculating a prediction rate of an appearance of symptoms of a mental illness by using AI models; dynamically selecting the most suitable AI model for mental health assessment; verifying a set of survey questions including a plurality of sub-questions depending on the calculated prediction rate; and; outputting result data by adjusting the prediction rate; and transmitting a control signal to the pharmaceutical mixer for the ADHD medicine based on the assessment of the mental health state.

IPC Classes  ?

• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/372 - Analysis of electroencephalograms
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

Disclosed are a lightweight checkpoint device and method for learning time series data. The checkpoint method is performed by a checkpoint device and comprises the steps of: training a learning model; generating full checkpoints by performing a checkpointing operation on the learning model when a first epoch is completed during the training of the learning model; performing the checkpointing operation at each checkpointing interval to generate partial checkpoints including a weight tensor including only elements having values different from those of elements of a weight tensor generated as a result of a previous checkpointing operation; and generating new full checkpoints by merging the generated partial checkpoints when an epoch corresponding to a merge point is completed during the training.

IPC Classes  ?

• G06N 3/0495 - Quantised networksSparse networksCompressed networks
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G06N 3/08 - Learning methods
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G06N 3/098 - Distributed learning, e.g. federated learning

Abstract

The present invention relates to a microfluidic chip, which includes cell inlets into which a fluid containing cells is injected, and a cell channel connected thereto; and extra cellular matrix (ECM) inlets into which a fluid containing an ECM component is injected, and an ECM channel connected thereto, wherein the cell channel is located adjacent to a part of one side of the ECM channel, and a micro barrier with a lower height than these channels is located between them and formed by arranging a plurality of concave patterns, curved in the direction of the ECM channel, at regular intervals. The present invention also relates to a method of forming a spheroid or organoid in vitro model using the same.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

Provided are Fc variants having improved half-life by binding to and unbinding from FcRn in a pH-dependent manner and which have improved selective binding to Fcγ receptors. The human Fc domain variants have lower capacity to bind to immune inhibiting receptor FcγRIIb and have higher capacity to bind to immune activating receptor FcγRIIa (increased A/I ratio) than a wild-type human antibody Fc domain and conventional antibodies approved as antibody therapeutic agents, thereby having remarkably improved ADCP induction ability and having maximized half-life in blood in which excellent pH-selective FcRn binding and unbinding capacity is exhibited, and thus bind to numerous peptide drug therapeutics having a low half-life and retention time in the body to enable the peptide drug therapeutics to have an increased blood half-life and exhibit long-term drug efficacy, and can maximize the immune mechanism of therapeutic protein drugs to be effectively used as an improved antibody drug.

IPC Classes  ?

• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• A61P 35/00 - Antineoplastic agents

Abstract

An oxygen partial pressure control device and a method for controlling same may be provided. Specifically, an oxygen partial pressure control device may be provided, the device comprising: an electrochemical cell; a sensor; a power source; and a processor, wherein the processor is configured to: set a target partial pressure of oxygen in a storage chamber; control the sensor to measure an initial partial pressure of oxygen in the storage chamber; control the sensor to measure a first change in the partial pressure of oxygen over time after a first time point at which the electrochemical cell is operated; control the sensor to measure a second change in the partial pressure of oxygen caused by air flowing into the storage chamber from the outside, thereby generating an oxygen partial pressure change function; generate an oxygen partial pressure control function for controlling the partial pressure of oxygen in the storage chamber; calculate a current to be applied to the electrochemical cell to maintain the partial pressure of oxygen in the storage chamber; and control the power source to apply the current to the electrochemical cell, thereby maintaining the partial pressure of oxygen in the storage chamber.

IPC Classes  ?

• F25D 17/04 - Arrangements for circulating cooling fluidsArrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection
• F25D 29/00 - Arrangement or mounting of control or safety devices
• A23B 7/148 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O
• C25B 1/02 - Hydrogen or oxygen
• C25B 9/00 - Cells or assemblies of cellsConstructional parts of cellsAssemblies of constructional parts, e.g. electrode-diaphragm assembliesProcess-related cell features

Abstract

The present invention relates to a novel Lactobacillus brevis NE428 strain and uses thereof. More specifically, the present invention relates to a Lactobacillus brevis NE428 strain (accession number: KCTC15727BP), a pharmaceutical composition comprising the strain as an active ingredient for preventing or treating Graves' disease, and a health functional food for preventing or alleviating Graves' disease. The novel Lactobacillus brevis NE428 strain according to the present invention has an effect of preventing, alleviating, and treating Graves' disease by, for example, reducing the concentration of thyroid hormones elevated in the blood by Graves' disease and decreasing thyroid size, and thus can be advantageously used in the preparation of a novel therapeutic agent and health functional food for Graves' disease.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61P 5/14 - Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
• A61P 37/00 - Drugs for immunological or allergic disorders
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• C12R 1/24 - Lactobacillus brevis

Abstract

This capacitive deionization (CDI) electrode comprises a current collector and an active material layer formed on one surface of the current collector, the active material layer comprising: a binder; and an activated carbon composite in which crystalline carbon is formed on the surface of activated carbon, wherein the specific surface area of the activated carbon exceeds 2000 m2/g and the volume of pores having a diameter of 2-5 nm in the activated carbon is at least 70 percent.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis

Abstract

The present invention relates to utilizing a prepared chiral ferromagnetic nanomaterial for a spintronic nanomaterial, such as an actual magnetic memory, and a device for measuring the asymmetrical magnetotransport property coupled with an electromotive force may include a rotating device that generates a rotational motion in an electrode; a stack stacked on the electrode; a chiral nanostructure in which a chiral ferromagnetic nanocoil is deposited on the stack, and, in response to the rotating device rotating, chirality-induced spin selectivity or the asymmetrical magnetotransport property may be measured through the chiral nanostructure.

IPC Classes  ?

• G01R 33/028 - Electrodynamic magnetometers

Abstract

A touch driver includes: a plurality of current conveyors connected to a plurality of touch electrodes, the plurality of current conveyor circuits configured to (i) receive a plurality of first currents from the plurality of touch electrodes, and (ii) generate a plurality of second currents having opposite directions to the plurality of first currents; a common current subtractor circuit configured to (i) receive the plurality of first currents and the plurality of second currents from the plurality of current conveyor circuits, and (ii) generate a plurality of output currents that are a sum of (a) a mean current of the plurality of second currents and (b) the plurality of first currents; a plurality of integrator circuits configured to generate a plurality of output voltages by integrating the plurality of output currents; and an analog-to-digital converter configured to convert the plurality of output voltages into digital signals corresponding to touch data.

IPC Classes  ?

• G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
• G06F 3/044 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means by capacitive means

Abstract

Provided are a processing device configured to compress the output data of a first layer into second compressed input data by extracting non-zero values from the output data of the first layer by using a stride-aware compressed sparse row (SCSR) algorithm based on stride of a second layer in the artificial neural network and output the second compressed input data as input data of the second layer.

IPC Classes  ?

• H03M 7/30 - CompressionExpansionSuppression of unnecessary data, e.g. redundancy reduction
• G06F 17/16 - Matrix or vector computation

Abstract

The present invention relates to a novel manufacturing method for tafamidis with excellent synthesis yield and cost-effectiveness. More specifically, the invention involves synthesizing tafamidis with a benzoxazole backbone by reacting 4-amino-3-hydroxybenzoic acid and 3,5-dichlorobenzaldehyde to form an imine, followed by oxidation cyclization using a cyanide anion-containing catalyst under basic conditions in air. This method excludes the use of additional oxidizing agents such as conventional metal catalysts and/or high concentrations of oxygen, while minimizing separation processes, resulting in a novel synthesis method for tafamidis with excellent synthesis yields.

IPC Classes  ?

• C07D 263/57 - Aryl or substituted aryl radicals

Abstract

The present invention relates to a technology for addressing resource allocation problems by solving the graph multi-coloring problem on a noisy intermediate-scale quantum (NISQ)-based quantum computer using a quantum approximate optimization algorithm (QAOA). A method of operation of a graph multi-coloring problem solving apparatus operated by a processor is provided.

IPC Classes  ?

• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]

Abstract

The present disclosure relates to quantum approximate optimization technology, and more particularly, to an apparatus and method for an improved quantum approximate optimization algorithm. In one embodiment, the disclosure describes a method for implementing a quantum approximate optimization algorithm, which is performed by a processor of a quantum computing device.

IPC Classes  ?

• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms

Abstract

The present invention relates to a combination regimen of Decitabine and Belotecan for preventing or treating ovarian cancer, and provides a pharmaceutical composition for preventing or treating ovarian cancer, the pharmaceutical composition being characterized by comprising Decitabine or a pharmaceutically acceptable salt or solvate thereof as an active ingredient, wherein the pharmaceutical composition is administered in combination with Belotecan or a pharmaceutically acceptable salt or solvate thereof.

IPC Classes  ?

• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23K 20/137 - Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen

Abstract

Disclosed are an apparatus and a method for providing an elderly mental care service. The psychological service providing device comprises: a psychological evaluation unit for transmitting a questionnaire and instructions to a user terminal and evaluating the psychology of a user on the basis of a response received from the user terminal; a psychological education providing unit for transmitting psychological education content to the user terminal; a memory training providing unit for transmitting hints for autobiographical memory and instructions for autobiographical memory to the user terminal, and evaluating the specificity of the autobiographical memory of the user on the basis of memory responses received from the user terminal; a cognitive training providing unit for transmitting cognitive training content to the user terminal; and a program recommendation unit for transmitting a list of content to be recommended to the user to the user terminal and controlling operations of the psychological evaluation unit, the psychological education providing unit, the memory training providing unit, and the cognitive training providing unit on the basis of selection information received from the user terminal.

IPC Classes  ?

• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06Q 50/20 - Education
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06N 20/00 - Machine learning

Abstract

The present disclosure relates to a novel method for preparing rucaparib capable of achieving excellent synthesis yield and reproducibility. In particular, the present disclosure relates to a novel preparation method for synthesizing rucaparib by first synthesizing an indole skeleton to which substituents are introduced to positions 2, 3, 4 and 6, and then performing a heptagonal lactam ring formation reaction between the substituents introduced to positions 3 and 4, and a novel intermediate that may be used in preparation thereof.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• C07C 201/12 - Preparation of nitro compounds by reactions not involving the formation of nitro groups
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
• C07C 231/14 - Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
• C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Abstract

The present invention relates to a thiobenzimidazole derivative preparation method, a novel intermediate therefor, and the like. The present invention uses an intermediate containing O-ethyl carbonodithioate or an intermediate containing methyl 3-mercaptopropionate so as to effectively synthesize a thiobenzimidazole derivative having anti-cancer activity.

IPC Classes  ?

• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 491/113 - Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring