Abstract

Disposed are a method for preparing cellulose-polyvinyl alcohol fabric with improved surface characteristics, cellulose-polyvinyl alcohol fabric with improved surface characteristics prepared thereby, and fabric for wound healing comprising same. The method for preparing cellulose-polyvinyl alcohol fabric with improved surface characteristics comprises, after preparing a composite including a cellulose-based polymer and a polyvinyl alcohol-based polymer, exposing the composite to an alkali solution. The cellulose-polyvinyl alcohol fabric with improved surface characteristics is prepared using the method for preparing cellulose-polyvinyl alcohol fabric with improved surface characteristics. The fabric for wound healing includes the cellulose-polyvinyl alcohol fabric with improved surface characteristics.

IPC Classes  ?

• D06M 15/333 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated alcohols or esters thereof of vinyl acetatePolyvinylalcohol
• D06B 7/00 - Mercerising, e.g. lustring by mercerising
• D06M 11/13 - Ammonium halides or halides of elements of Groups 1 or 11 of the Periodic Table
• D06M 11/51 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof
• D06M 13/144 - AlcoholsMetal alcoholates
• D06M 101/06 - Vegetal fibres cellulosic

Abstract

A ruthenium-based nano-catalyst for a hydrogen generation reaction having excellent catalytic activity and efficiency by the catalyst surface structure, a method for preparing the same, a hydrogen generation electrode and a water electrolysis system.

IPC Classes  ?

• C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/037 - Electrodes made of particles
• C25B 11/065 - Carbon

Abstract

The present invention relates to a ternary logic circuit and, more particularly, to a ternary logic circuit using an anti-ambipolar transistor (AAT), and a method for designing a ternary logic circuit. The present invention relates to a ternary logic circuit and a method for designing a ternary logic circuit in which a more efficient ternary logic circuit can be implemented by outputting three states by using three transistors respectively connected to three different voltage sources, and a leakage current can be greatly reduced by using an AAT.

IPC Classes  ?

• H03K 19/094 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits using specified components using semiconductor devices using field-effect transistors
• H03K 19/00 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]
• H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing
• G06F 30/32 - Circuit design at the digital level

Abstract

An embodiment of the present invention provides a guide system for correcting the rotational alignment of a femur using artificial intelligence image processing and a method therefor, wherein the guide system comprises: an imaging device for capturing images of affected and the unaffected sides of a patient; an image display device for displaying the affected side image containing the femur coupled with an implant and the unaffected side image containing the normal femur captured by the imaging device; and a user device that acquires an affected side image and an unaffected side image from the affected side and unaffected side images, respectively, and aligns the affected side image with the unaffected side image on the basis of the femur to calculate the rotational angle difference between the fractured femur in the affected side image and the normal femur in the unaffected side image using artificial intelligence image processing, thereby guiding the rotational alignment correction of the affected side.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06T 3/60 - Rotation of whole images or parts thereof
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration
• G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation
• G06T 5/80 - Geometric correction
• G06T 5/73 - DeblurringSharpening
• G06T 3/4053 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on super-resolution, i.e. the output image resolution being higher than the sensor resolution
• G06T 5/70 - DenoisingSmoothing
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

The present invention relates to a ternary full adder circuit and, more specifically, to a ternary full adder circuit using an anti-ambipolar transistor, and a ternary full adder circuit design method, wherein the ternary full adder circuit is implemented using the anti-ambipolar transistor to implement an intermediate state, so that leakage current generated during a switching operation can be significantly reduced.

IPC Classes  ?

• G06F 30/327 - Logic synthesisBehaviour synthesis, e.g. mapping logic, HDL to netlist, high-level language to RTL or netlist
• G06F 30/337 - Design optimisation
• G06F 7/49 - Computations with a radix, other than binary, 8, 16 or decimal, e.g. ternary, negative or imaginary radices, mixed radix
• G06F 7/501 - Half or full adders, i.e. basic adder cells for one denomination
• H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing
• G06F 30/32 - Circuit design at the digital level
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

Disclosed are a three-terminal synapse device which does not include a channel and includes a gate-electrolyte separation layer between a gate layer and an electrolyte layer; a method for manufacturing same, and a method for operating same. The three-terminal synapse device may comprise: an electrolyte layer containing a first metal oxide; a gate layer which is disposed on the electrolyte layer and contains a second metal oxide different from the first metal oxide; a gate capping layer which is in contact with and above the gate layer and contains an electrically conductive material; a source electrode in contact with the electrolyte layer and disposed on a first side surface of the electrolyte layer; and a drain electrode in contact with the electrolyte layer and disposed on a second side surface opposite the first side surface of the electrolyte layer.

IPC Classes  ?

• H10N 70/20 - Multistable switching devices, e.g. memristors
• H10N 70/00 - Solid-state devices having no potential barriers, and specially adapted for rectifying, amplifying, oscillating or switching
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

The present invention relates to a promoter-dependent AD5 cancer lysis virus expressing an EBV gene BZLF1, and a use thereof. In particular, tumor-specific promoters hTERT, E1A, IRES and E1B were inserted into an Ad5 adenovirus vector and BZLF1 was inserted under a CMV promoter so as to increase the activity of the hTERT promoter in cancer cells, and thus developed an oncolytic virus in which E1A, E1B and BZLF1 are expressed. The oncolytic virus according to the present invention is expected to be effectively used as a third-line cancer therapeutic agent for recurrent and metastatic EBV-positive gastric cancer.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 35/761 - Adenovirus
• A61P 35/00 - Antineoplastic agents

Abstract

A method for generating a three-dimensional digital surface model of the present invention may comprise the steps of: acquiring a multi-view satellite image of a target place; estimating pose information of a satellite camera that captured the multi-view satellite image on the basis of the multi-view satellite image; generating a primary digital surface model of the target place on the basis of the multi-view satellite image and the pose information of the satellite camera; restoring the distortion of the primary digital surface model by means of a three-dimensional homography transformation matrix; calculating a virtual RPC for the multi-view satellite image on the basis of the multi-view satellite image and the three-dimensional homography transformation matrix; and generating a secondary digital surface model of the target place by using the multi-view satellite image and the virtual RPC.

IPC Classes  ?

• G06T 17/05 - Geographic models
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06T 5/00 - Image enhancement or restoration
• G06T 3/06 - Topological mapping of higher dimensional structures onto lower dimensional surfaces
• G06T 7/215 - Motion-based segmentation
• G06T 3/18 - Image warping, e.g. rearranging pixels individually

Abstract

A gas analysis device for on-site diagnosis according to the present invention comprises: a gas injection unit into which a sample gas for analysis and a carrier gas for moving the sample gas are injected and which is provided to discharge a portion of the injected sample gas and carrier gas to the outside; a gas separation unit which is supplied with the sample gas and carrier gas merged by the gas injection unit and has a heating member and a cooling member for separating impurities included in the supplied sample gas; a control unit which is connected to the gas separation unit and the gas injection unit and adjusts the amount of the sample gas and carrier gas supplied to the gas injection unit or adjusts the temperature of the sample gas by using at least one of the heating member or the cooling member according to the type of the sample gas supplied to the gas separation unit; and a gas analysis unit for analyzing the sample gas that passes through the gas separation unit.

IPC Classes  ?

• G01N 30/30 - Control of physical parameters of the fluid carrier of temperature
• G01N 30/02 - Column chromatography

Abstract

A multifunctional biobased waterborne polyurethane composition includes, based on 100 parts by weight of the polyurethane composition, 40 to 50 parts by weight of a polyol, 34 to 42 parts by weight of an isocyanate, 8 to 14 parts by weight of a chain extender, 0.03 to 0.12 parts by weight of a catalyst, and 0.005 to 0.02 parts by weight of a neutralizing agent.

IPC Classes  ?

• C08G 18/64 - Macromolecular compounds not provided for by groups

Abstract

The present invention relates to a cellulose-based hydrogel bead preparation method, hydrogel beads prepared thereby, and an absorbent article comprising same, the preparation method enabling hydrogel beads to be washed with water without a separate organic solvent in a post-treatment process and shortening a drying time of the hydrogel beads, thereby enabling excellent economic feasibility and safety. In addition, the hydrogel beads prepared by the preparation method and the absorbent article comprising same may have excellent water absorption capacity and atmospheric water capturing ability while also being biodegradable, thereby being environmentally friendly and easily recyclable.

IPC Classes  ?

• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08J 3/12 - Powdering or granulating
• C08J 3/075 - Macromolecular gels
• C08K 5/1515 - Three-membered rings
• C08K 5/07 - AldehydesKetones
• C08K 3/22 - OxidesHydroxides of metals
• A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
• A61L 15/28 - Polysaccharides or their derivatives
• A61L 15/62 - Hydrosoluble or hydrodegradable materials
• C09K 17/18 - PrepolymersMacromolecular compounds

Abstract

A manufacturing method of a porous polyimide film, includes: preparing a polyamic acid solution at a concentration of 10 to 30 wt % by dissolving a diamine compound and a dianhydride in a solvent; applying the prepared polyamic acid solution to a substrate to prepare a film and then immersing the same in a non-solvent for 30 minutes to 180 minutes; and taking out the immersed film and thermally curing the same; and a porous polyimide film manufactured thereby.

IPC Classes  ?

• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08J 5/18 - Manufacture of films or sheets
• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
• C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
• C08K 9/02 - Ingredients treated with inorganic substances
• H05K 9/00 - Screening of apparatus or components against electric or magnetic fields

Abstract

The present invention relates to an ultrasonic odometry measuring device and a method thereof, the ultrasonic odometry measuring device, according to one embodiment, comprising: a data collection unit for collecting sensing data including ultrasonic image data by using a sensor equipped in an underwater robot; an information calculation unit for calculating keyframe selection information on the basis of the collected sensing data; a keyframe calculation unit for, on the basis of the calculated keyframe selection information, calculating, as keyframes, a plurality of image frames among image frames constituting the ultrasonic image data; and a distance travelled calculation unit for calculating the distance travelled by the underwater robot through a Fourier-based image registration process for the keyframes.

IPC Classes  ?

• G01C 22/00 - Measuring distance traversed on the ground by vehicles, persons, animals or other moving solid bodies, e.g. using odometers or using pedometers
• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration
• G06F 17/10 - Complex mathematical operations

Abstract

The present invention relates to a composition, for preventing, relieving, or treating a muscle weakness-related disease, comprising a celery seed extract. The celery seed extract according to the present invention causes a few or no side effects by using a natural product, may increase muscle mass and muscle strength to not only prevent muscle weakness but also inhibit weight gain and body fat increase, and may reduce serum lipid profiles and hepatotoxicity markers (GOT and GPT), and thus is expected to be utilized for preventing, relieving, or treating muscle weakness-related diseases, metabolic diseases, liver diseases, or the like.

IPC Classes  ?

• A61K 36/23 - Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

The present invention provides a photo-charging energy storage device and a manufacturing method therefor. The present invention comprises: a solar cell unit; an energy storage element unit for charging a current that is output from the solar cell unit; and a common electrode for connecting the solar cell unit and the energy storage element unit, wherein the common electrode transports electric charges from the solar cell unit to only the energy storage element unit.

IPC Classes  ?

• H01L 31/053 - Energy storage means directly associated or integrated with the PV cell, e.g. a capacitor integrated with a PV cell
• H01L 31/032 - Inorganic materials including, apart from doping materials or other impurities, only compounds not provided for in groups
• H01L 31/075 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PIN type, e.g. amorphous silicon PIN solar cells
• H01L 31/0216 - Coatings
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 30/15 - Sensitised wide-bandgap semiconductor devices, e.g. dye-sensitised TiO2
• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/50 - Photovoltaic [PV] devices
• H10K 30/85 - Layers having high electron mobility, e.g. electron-transporting layers or hole-blocking layers
• H10K 30/86 - Layers having high hole mobility, e.g. hole-transporting layers or electron-blocking layers

Abstract

The present invention relates to a method for preparing cross-linked hyaluronic acid nanoparticles, comprising forming intermolecular or intramolecular cross-linking by irradiating a hyaluronic acid aqueous solution with an electron beam. There are provided uses of synthesized hyaluronic acid nanoparticles as a contrast agent for tumor diagnosis and a therapeutic agent through the skin permeability confirmed by fluorescence labeling and radioactive labeling by uniformly synthesizing hyaluronic acid nanoparticles having various nano-meter sizes reproducibly under an optimized electronic beam condition.

IPC Classes  ?

• A61K 51/06 - Macromolecular compounds
• A61K 8/67 - Vitamins
• A61K 8/73 - Polysaccharides
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
• A61Q 19/08 - Anti-ageing preparations

Abstract

The present invention relates to a multi-level power conversion system comprising: a reactive power compensation unit provided to compensate for reactive power required by a power system, and including a plurality of legs; and a transformer unit connected between the power system and the reactive power compensation unit, wherein the transformer unit includes a zigzag transformer that provides, to the reactive power compensation unit, a zero sequence current path for balancing energy between the plurality of legs. Accordingly, in a multi-level power conversion system including a star-connected converter, the leg energy balance is controlled by a zero sequence current flow, such that a high voltage margin is secured, thereby stably reinforcing the system against vulnerabilities caused by surges in power supply and demand.

IPC Classes  ?

• H02J 3/18 - Arrangements for adjusting, eliminating or compensating reactive power in networks
• H02M 7/483 - Converters with outputs that each can have more than two voltage levels
• H02M 7/493 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode the static converters being arranged for operation in parallel

Abstract

The present invention relates to a composition for alleviating, inhibiting, treating or preventing macular degeneration. The composition according to the present invention has excellent effects of reducing angiogenesis due to macular degeneration and inhibiting vascular leakage, and thus can be used as a therapeutic agent for alleviating or treating macular degeneration, particularly age-related macular degeneration (AMD).

IPC Classes  ?

• A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
• A61P 27/02 - Ophthalmic agents
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

Disclosed are a method, a device, and a system for processing a degaussing of a ship capable of processing the degaussing even during sailing of the ship. A method for processing a degaussing of a ship disclosed herein, according to one embodiment, comprises the steps of: performing degaussing processing before sailing of a ship in a magnetic processing station; calculating a first compensation current for compensating for a magnetic field generated during sailing of the ship on the basis of ship sailing-related information of the ship; and calculating a second compensation current for compensating for a magnetic field generated during sailing according to occurrence of a preset event during sailing of the ship.

IPC Classes  ?

• B63G 9/06 - Other offensive or defensive arrangements on vessels against submarines, torpedoes, or mines for degaussing vessels
• B63B 79/30 - Monitoring properties or operating parameters of vessels in operation for diagnosing, testing or predicting the integrity or performance of vessels
• B63B 79/10 - Monitoring properties or operating parameters of vessels in operation using sensors, e.g. pressure sensors, strain gauges or accelerometers
• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
• G01R 15/20 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using galvano-magnetic devices, e.g. Hall-effect devices
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables
• H01L 29/82 - Types of semiconductor device controllable by variation of the magnetic field applied to the device

Abstract

A composite material reinforcement device may include: a central portion including an edge portion provided to have an inner space having a trapezoidal cross-section with reference to a longitudinal direction, and a partition wall portion dividing the inner space into at least one partition space; and a reinforcement portion located on a top and a bottom of the central portion and integrally molded to cover the central portion, wherein the reinforcement portion includes: a first plate located on the top of the central portion to cover an upper portion of the central portion; a second plate curved to correspond to a shape of the central portion and located at the bottom of the central portion to cover a lower portion of the central portion; and an extension portion in which the first plate and the second plate extend from both ends of the central portion to be bonded to each other.

IPC Classes  ?

• E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground

Abstract

Disclosed are an exterior cover, an electronic device comprising same, and a manufacturing method therefor according to one embodiment. The exterior cover comprises: a first material including recycled aluminum; and a second material coupled to the first material and including a metal having a higher strength than the recycled aluminum, wherein at least one pattern structure may be formed on a surface on which the first material and the second material are coupled. Various other embodiments may be possible.

IPC Classes  ?

• H05K 5/03 - Covers
• H05K 5/04 - Metal casings
• H05K 5/00 - Casings, cabinets or drawers for electric apparatus
• H04M 1/02 - Constructional features of telephone sets
• B22F 7/04 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite layers with one or more layers not made from powder, e.g. made from solid metal
• B22F 7/08 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite workpieces or articles from parts, e.g. to form tipped tools with one or more parts not made from powder
• C22C 21/06 - Alloys based on aluminium with magnesium as the next major constituent
• C22C 21/10 - Alloys based on aluminium with zinc as the next major constituent
• B33Y 10/00 - Processes of additive manufacturing
• B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]

Abstract

The present invention relates to a super-water-repellent three-dimensional structure using capillary-force-induced aggregation, and a manufacturing method therefor. Provided are a super-water-repellent three-dimensional structure using capillary-force-induced aggregation, and a manufacturing method therefor, the method comprising: an upright hierarchical column formation step of using polydimethylsiloxane, which is an elastic material, so as to form an upright hierarchical column structure in which a plurality of protrusions are formed on the top of a column that is narrow at the top and wide at the bottom; an aggregation induction step of applying polyvinyl alcohol to the surface of the upright hierarchical column structure and drying same, thereby inducing aggregation between the protrusions by means of capillary force; a curing step of applying polydimethylsiloxane to the protrusions, and curing same to fix same in an aggregated state; a water repellency provision step of applying a hydrophobic wax solution to the front surface of the upright hierarchical column structure; and a coating step of coating the protrusions with a polydopamine aqueous solution, which is a hydrophilic solution.

IPC Classes  ?

• C08J 7/054 - Forming anti-misting or drip-proofing coatings
• C08J 7/04 - Coating
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
• B29C 33/40 - Plastics, e.g. foam or rubber
• C08L 83/04 - Polysiloxanes
• C08L 29/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• C09D 5/16 - Anti-fouling paintsUnderwater paints
• C09D 165/00 - Coating compositions based on macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCoating compositions based on derivatives of such polymers
• C09D 191/06 - Waxes

Abstract

The present invention relates to a 3D microstructure replication method using a Poisson effect. According to the present invention, provided is a 3D microstructure replication method using a Poisson effect, comprising: a soft mold preparation step for forming a soft mold by transferring a superelastic material to a master mold by a soft lithography method; a resin application step for applying a resin to the soft mold; a compression step for applying vertical pressure to the upper surface of the soft mold and transforming the shape of the soft mold by using the Poisson effect due to the vertical pressure; a resin curing step for curing the resin by applying heat or ultraviolet rays to the transformed soft mold to generate a 3D microstructure; and a releasing step for removing the vertical pressure to restore the shape of the soft mold and releasing the 3D microstructure.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B29C 59/02 - Surface shaping, e.g. embossingApparatus therefor by mechanical means, e.g. pressing

Abstract

A gadolinium-based compound and an MRI contrast agent comprising same are disclosed. The gadolinium-based compound may be a DO3A-based gadolinium compound bound to protocatechuic acid. The MRI contrast agent may comprise the compound. In addition, disclosed is a pharmaceutical composition for preventing or treating neuroinflammatory diseases, comprising the compound or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 49/10 - Organic compounds
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table

Abstract

The present invention relates to a boronic acid functional pressure-sensitive adhesive. More specifically, the present invention provides a method for manufacturing a boronic acid functional pressure-sensitive adhesive, the method comprising the steps of: synthesizing a scaffold pressure-sensitive adhesive by reacting butyl acrylate with glycidyl methacrylate; and synthesizing a boronic acid pressure-sensitive adhesive by reacting a scaffold pressure-sensitive adhesive with 4-mercaptophenylboronic acid. In addition, the present invention provides a boronic acid functional pressure-sensitive adhesive comprising a boronic acid group and a butyl group. In addition, the present invention provides a functional coating material and an antifouling coating composition, comprising the boronic acid pressure-sensitive adhesive according to the present invention.

IPC Classes  ?

• C09J 143/00 - Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium, or a metalAdhesives based on derivatives of such polymers
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 5/16 - Anti-fouling paintsUnderwater paints
• C09D 143/00 - Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium or a metalCoating compositions based on derivatives of such polymers
• C08F 8/42 - Introducing metal atoms or metal-containing groups
• C08F 220/32 - Esters containing oxygen in addition to the carboxy oxygen containing epoxy radicals

Abstract

Polyscias fruticosaPolyscias fruticosaPolyscias fruticosa can be presented as a novel high value-added farm income crop.

IPC Classes  ?

• A61K 36/25 - Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/04 - Antibacterial agents
• A61P 31/12 - Antivirals
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

The present invention relates to a dual-mode probe for detecting of hydrogen sulfide and use thereof and, more specifically to a dual-mode probe that has excellent blood-brain barrier permeability and is capable of fluorescence and nuclear imaging and a use thereof for detecting hydrogen sulfide.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07F 1/08 - Copper compounds

Abstract

According to the present invention, a multi-detection analysis method of a biological sample includes a step of preparing a plurality of a magnetic encoded microparticles encoded in different types and introducing the plurality of a magnetic encoded microparticles into a sample of an analysis target, a step of acquiring a video of the sample in a state where the sample is exposed to a rotating magnetic field, a step of inputting a time-series image included in the video into a pre-trained deep learning algorithm, analyzing rotation pattern characteristics of each magnetic encoded microparticle in the video over time through the deep learning algorithm, and classifying each magnetic encoded microparticle, and a step of multi-detecting a plurality of types of target materials in the sample based on a classification result of each magnetic encoded microparticle in the video.

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G06T 7/20 - Analysis of motion
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

The present invention relates to a multipurpose biodegradable cleaner and a method for producing same. The multipurpose biodegradable cleaner uses a 100% biodegradable fabric to address waste and environmental pollution issues caused by existing non-degradable fabrics, and has a non-slip layer on the rear surface of an anti-fog layer, thus providing less discomfort during use and providing functionality for touch-up makeup, and can therefore contribute to user convenience and portability. In addition, the present invention contains hyaluronic acid, ceramide, flower acid, and a natural extract and can thus provide a high degree of moisturization and keratolytic, anti-inflammatory, and antibacterial effects and the like, and can help provide the user with psychological stability, stress relief, fatigue recovery, and the like by means of aromatic particles in a fragrance capsule.

IPC Classes  ?

• D06M 23/12 - Processes in which the treating agent is incorporated in microcapsules
• D06M 15/693 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials with macromolecular compoundsSuch treatment combined with mechanical treatment with natural or synthetic rubber, or derivatives thereof
• D06M 11/73 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof
• D06M 11/79 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with silicon dioxide, silicic acids or their salts
• D06M 11/46 - Oxides or hydroxides of elements of Groups 4 or 14 of the Periodic TableTitanatesZirconatesStannatesPlumbates
• D06M 23/06 - Processes in which the treating agent is dispersed in a gas, e.g. aerosols
• D06M 101/06 - Vegetal fibres cellulosic
• D06M 101/32 - Polyesters
• D06M 101/18 - Synthetic fibres consisting of macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to an optoelectronic module using spatial light modulators and an optical computer comprising same. The optoelectronic module using the spatial light modulators comprises: a plurality of first light sources; a plurality of first lenses that reduce the divergence angles of light rays emitted from the first light sources; a plurality of spatial light modulators that adjust the intensity of light rays that pass through the first lenses; a plurality of light detectors that acquire a current value dependent on light intensity; and a lens unit that focuses the light rays, emitted from the first different light sources, onto one of the light detectors. The lens unit carries out the function of calculating the convolution of a light source array and a pixel array of the spatial light modulators by using the function of focusing the light rays, emitted from the first different light sources, onto the one light detector.

IPC Classes  ?

• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06E 3/00 - Devices not provided for in group , e.g. for processing analogue or hybrid data
• G02B 26/02 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
• G02B 27/09 - Beam shaping, e.g. changing the cross-sectioned area, not otherwise provided for

Abstract

The present invention relates to a ferritin nanocage fused with a LAG3 binding peptide and use thereof as an anticancer immunotherapeutic agent, in which, by respectively fusing peptides that bind to immune checkpoint receptor LAG3 (LAG3pep1: CIRNDPAVC and LAG3pep2: CSVLNASGC) to loops protruding from the surface of human ferritin to form a cage, a nanocage in which 24 LAG3 binding peptides are displayed was produced. The nanocage of the present invention increased immune activity by specifically binding to LAG3 receptors and blocking LAG3, and exhibited an anticancer effect by effectively targeting brain cancer tissues through BBB. In addition, an immune checkpoint blocking nanocage in which an LAG3 binding peptide and a PD-L1 binding peptide are fused together specifically binds to each receptor, thereby exhibiting a bifunctional immune checkpoint blocking effect. Therefore, the nanocage technology of the present invention is expected as a next-generation drug that overcomes the limitations of immune checkpoint blocking therapy using antibodies.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a bio-implantable actuator and an artificial joint comprising the same and, more specifically, to a bio-implantable actuator and an artificial joint comprising same, the bio-implantable actuator being capable of transmitting motion force and capable of reducing a load applied to a joint, without limiting the degree of freedom of motion of the joint. The bio-implantable actuator according to an embodiment of the present invention comprises: a power unit generating a rotational force; a linear motion unit that is connected to the power unit and converts rotational motion of the power unit into linear motion; and a flexible rod connected to the linear motion unit. In addition, the bio-implantable actuator according to another embodiment of the present invention comprises: a tube having one open end and a hollow portion; a linear motion unit disposed inside the tube; and a flexible rod having one end disposed inside the tube so as to be connected to the linear motion unit and the other end protruding to the outside of the tube.

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees
• A61F 2/48 - Operating or control means, e.g. from outside the body, control of sphincters
• A61F 2/30 - Joints

Abstract

The present invention relates to a method for manufacturing a Mg/Ti composite, and a metal composite manufactured thereby, the method immersing, in a molten metal that contains (Mg) and calcium (Ca), a precursor alloy (Ti-X) that contains titanium (Ti) and a metal (X), which is miscible with the molten metal so as to be dissolved into the molten metal, wherein the Ca alloy element, which is included in a molten Mg-Ca alloy, is highly miscible with Cu so as to promote dealloying behavior by which Cu is dissolved into the molten metal, thereby greatly reducing process time, is dissolved in Mg matrix so as to increase the volume fraction of the Mg matrix in the composite, and reduces the coarsening rate of Ti and, simultaneously, improves the strength of the composite through solid-solution strengthening of the Mg matrix.

IPC Classes  ?

• C22C 1/02 - Making non-ferrous alloys by melting
• C22C 23/00 - Alloys based on magnesium

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating hearing loss, the composition containing berberine chloride as an active ingredient. The pharmaceutical composition was found to effectively inhibit hair cell apoptosis caused by reactive oxygen species and exhibit an excellent protective effect on hair cells, and thus can be effectively used as a drug or health supplement for preventing or treating hearing loss.

IPC Classes  ?

• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61P 27/16 - Otologicals
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a method for manufacturing a Mg/TiAl composite, and a Mg/TiAl composite manufactured thereby, the method comprising the steps of: (a) immersing, in a molten metal containing magnesium (Mg), a precursor alloy (Ti-X) containing a metal (X), which is miscible with titanium (Ti) and is to be dissolved in the molten metal, thereby manufacturing a Mg/Ti composite; (b) manufacturing a titanium (Ti) porous structure from the Mg/Ti composite; and (c) immersing the titanium (Ti) porous structure in a molten Mg-Al alloy, thereby manufacturing a Mg/TiAl composite. A magnesium matrix material is removed from a Mg-Ti composite manufactured through liquid metal dealloying (LMD), and then aluminum alloying is performed using the molten Mg-Al alloy, and thus a Mg/TiAl composite structured to be a three-dimensionally interconnected, in which an element such as copper (Cu) contained in the precursor alloy does not remain and which has excellent physical properties, can be manufactured.

IPC Classes  ?

• C22C 1/02 - Making non-ferrous alloys by melting
• C22C 23/00 - Alloys based on magnesium
• C22C 1/08 - Alloys with open or closed pores

Abstract

The present invention relates to a novel compound comprising an ester group and uses thereof and, more particularly, to a novel compound that exhibits excellent visualization ability in a tumor by using the difference in activity of esterase for each organ in the body, and to uses therefor for diagnosing or treating cancer. A novel compound of chemical Formulas 1 to 8 according to the present invention exhibits selectivity according to the difference in activity of esterase for each organ due to ester residue in a structure, and thus is extremely effective in visualizing pancreatic cancer, etc.

IPC Classes  ?

• C07F 1/08 - Copper compounds
• A61K 51/04 - Organic compounds
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

The present disclosure relates to ultra-high speed digital signal integrity improving structures. Each structure in the present disclosure includes a first unit structure and a second unit structure of the same or different shapes arranged to face each other on the left and right sides along a longitudinal direction of a balanced line, centered around a coplanar stripline (CPS) or parallel stripline (PSL) formed on a substrate. At least one of the first unit structure and the second unit structure includes a first side close to the balanced line and having a linear or curve shape; a second side facing the first side; and left and right sides connecting the first side and the second side. Here, the width of the first side is less than or equal to that of the second side, the left and right sides have a linear or non-linear slope, and the width from the first side to the second side is configured to change continuously or discontinuously. When the structures of the present disclosure are disposed around a balanced line, it has the advantage of being able to recover the distorted phase autonomously while rejecting a common-mode signal in a frequency band up to 40 GHz or more.

IPC Classes  ?

• H01P 1/00 - Auxiliary devices
• H01P 3/08 - MicrostripsStrip lines

Abstract

The present invention relates to a method for manufacturing an imide-based porous film, being capable of pore shape control, in which a porogen is dispersed in a polyamic acid solution to form a porous polyimide film, and the concentrations of the porogen and nanoparticles are adjusted to control pores, thereby manufacturing an imide-based porous film that is heat resistant to high temperatures.

IPC Classes  ?

• C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
• C08J 5/18 - Manufacture of films or sheets
• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors

Abstract

Provided is a battery management system including: a battery management device, disposed on a mobile vehicle, for measuring battery information from a battery; a cloud server device for collecting the battery information from the battery management device and storing the battery information, and for, based on determination condition and service command of pre-registered battery management service, if it is determined that there exists battery information matching the determination condition, controlling a resulting information to be created from the extracted information in accordance with the service command; and a terminal device for receiving and outputting the resulting information.

IPC Classes  ?

• G06F 1/3212 - Monitoring battery levels, e.g. power saving mode being initiated when battery voltage goes below a certain level

Abstract

A geometric phase optical element according to the present invention comprises: an optically anisotropic material; and a phase retardation layer with a quarter-waveplate phase retardation amount, wherein: the phase retardation layer receives incident light and outputs modulated light and unmodulated light; and the modulated light and the unmodulated light, which are output from the phase retardation layer, may have the same intensity.

IPC Classes  ?

• G02B 5/30 - Polarising elements
• G02B 5/02 - Diffusing elementsAfocal elements
• G02B 3/00 - Simple or compound lenses

Abstract

The present invention relates to peptides binding to LAG-3 and a use thereof in cancer immunotherapy and anticancer applications. The peptides of the present invention specifically bind to and inhibit LAG-3, thereby activating the function of immune cells against cancer cells and exhibiting anticancer effects. Using phage peptide display technology targeting cells with high expression of human LAG-3 protein, two peptides, LAG-3Pep-1 and LAG-3Pep-2, which were found to highly bind to the protein, were selected as the peptides of the present invention. These peptides were confirmed to bind to both human and mouse LAG-3 and inhibit its function. The peptides of the present invention showed effects similar to those of antibodies and were relatively stable in the bloodstream, indicating high potential as future cancer immunotherapeutics.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/08 - Peptides, e.g. proteins
• A61P 35/00 - Antineoplastic agents
• A61K 38/00 - Medicinal preparations containing peptides
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The double-membrane composite for intestinal anastomosis protection of the present invention comprises an inner membrane that contacts biological tissue and is composed of a bio-friendly, biodegradable polymer having a functional group introduced thereinto; and an outer membrane formed on one surface of the inner membrane and composed of a cross-linked anti-adhesive biodegradable polymer. According to the present invention, the intestinal anastomosis site is protected by the inner membrane of the mesh, while the outer membrane of the mesh can prevent unnecessary adhesion to other organs.

IPC Classes  ?

• A61L 31/04 - Macromolecular materials
• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61L 31/14 - Materials characterised by their function or physical properties
• A61L 27/14 - Macromolecular materials
• A61L 27/50 - Materials characterised by their function or physical properties
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention relates to a photocatalyst and a preparation method therefor. The photocatalyst according to the present invention comprises titanium dioxide with a bronze crystal phase and an anatase crystal phase so as to have high photoactivity, and thus is suitable for removing odors and toxic gases. In addition, the titanium dioxide included in the photocatalyst, according to the present invention, has a novel crystal phase having a charge separation effect superior to those of other crystal phases, and thus has improved photoactivity. Additionally, the photocatalyst of the present invention has high photoactivity, and thus is suitable for removing odors and toxic gases. In addition, the photocatalyst of the present invention has excellent durability against catalytic poisons formed on the surface of a catalyst during removal of VOCs and toxic gases (acetaldehyde, isovaleraldehyde, isovaleric acid and toluene).

IPC Classes  ?

• B01J 35/39 - Photocatalytic properties
• B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
• B01J 35/23 - Catalysts, in general, characterised by their form or physical properties characterised by their non-solid state in a colloidal state
• B01J 37/10 - Heat treatment in the presence of water, e.g. steam

Abstract

A light-collecting device according to an embodiment has a robot manipulator and comprises: a sensing portion for acquiring information regarding the position and direction of the light-collecting device; a measurement portion for measuring the actual incident angle of the sun; a computation portion for assessing the theoretical position value of the sun by using information from the sensing portion, the computation portion comprising a first computation member for calculating the position and direction of the sun on the basis of the sensing portion's GPS and compass sensor values, a second computation member for reading the measurement portion's light-dependent resistor 16-array sensor values so as to calculate the offset from the actual position and direction of the sun, and a third computation member for solving inverse kinematics such that an end-effector faces in the position and direction of the sun calculated by the first or second computation member; a controller for controlling the robot manipulator by using information from the computation portion and the measurement portion; a heat-collecting portion disposed on an end of the robot manipulator so as to collect sunlight, thereby heating a focal point; and a battery. The controller may precisely correct the robot manipulator such that the plane of the heat-collecting portion is perpendicular to the incident angle of the sun.

IPC Classes  ?

• F24S 30/48 - Arrangements for moving or orienting solar heat collector modules for rotary movement with three or more rotation axes or with multiple degrees of freedom
• F24S 50/20 - Arrangements for controlling solar heat collectors for tracking
• F24S 23/30 - Arrangements for concentrating solar rays for solar heat collectors with lenses
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• B25J 11/00 - Manipulators not otherwise provided for
• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices

Abstract

The present invention relates to a transition metal complex catalyst composition for polymerization of a monomer having a cyclic ester group and a method of producing a polymer using the same. More particularly, the invention provides a catalyst composition comprising a transition metal complex containing aminopyridine and aminoquinoline ligands, and a method of producing a polymer having high heterotacticity with high conversion rate even at room temperature by using the same. Since the catalyst composition for polymerization of a monomer having a cyclic ester group according to the invention comprises a transition metal compound that is chemically stable in air, it is capable of effectively producing a polymer having high heterotacticity (Pr) with high conversion rate at room temperature or below room temperature without satisfying high-temperature conditions.

IPC Classes  ?

• C08G 63/82 - Preparation processes characterised by the catalyst used
• C07F 1/08 - Copper compounds
• C07F 3/06 - Zinc compounds
• C07F 15/06 - Cobalt compounds
• C08G 63/08 - Lactones or lactides

Abstract

Provided is a spine fixing device including: a base plate; a cage configured to be coupled to the base plate; a first wing plate configured to be coupled to an upper portion of a composite body of the base plate and the cage; and a second wing plate configured to be coupled to a lower portion of the composite body of the base plate and the cage.

IPC Classes  ?

• A61B 17/70 - Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant

Abstract

The present invention relates to an extracellular vesicle expressing a cytokine and an antibody, a method for producing same, and a use thereof. The present invention provides a method for producing an immune cell expressing both a cytokine and an antibody on membrane surface by transforming them with a first vector encoding a cytokine and a second vector encoding an antibody, and producing their extracellular vesicle expressing both a cytokine and an antibody on the surface. The present invention provides the extracellular vesicle which induces a desired cytokine response in cells that can be targeted with a specific antibody and is safe for the human body while exhibiting excellent anticancer effects. The present invention provides a new cancer treatment means that deliver drugs or physiologically active substances to specific cancer cells by loading a drug or physiologically active substance that exhibits a therapeutic effect on cancer in the extracellular vesicle.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/20 - Interleukins
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a method for manufacturing a personalized lip retractor, comprising the steps of: collecting, by a collection unit, facial information about a user; detecting, by an analysis unit, a smile line of the user from the facial information and analyzing the smile line; generating, by a generation unit, on the basis of the analyzed smile line, a personalized smile line optimized for the face of the user to correct the smile line of the user; designing, by a design unit, the shape of a personalized lip retractor according to the generated smile line; and manufacturing, by a manufacturing unit, the personalized lip retractor according to the designed shape. Accordingly, a lip retractor that can perform training to induce contraction of relevant muscles to form an aesthetic smile can be provided, and a smile line of an individual user can be analyzed and a lip retractor can be manufactured in the shape of a lip line that is tailored to the individual user according to the result of analyzing the smile line.

IPC Classes  ?

• A61C 13/00 - Dental prosthesesMaking same
• A61C 9/00 - Impression methods specially adapted for dental prostheticsImpression cups therefor
• G06T 1/00 - General purpose image data processing
• G06T 7/00 - Image analysis
• G16H 30/00 - ICT specially adapted for the handling or processing of medical images
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• A45D 44/12 - Ear, face, or lip protectors
• A61C 5/90 - Oral protectors for use during treatment, e.g. lip or mouth protectors
• A61C 5/00 - Filling or capping teeth

Abstract

The present invention relates to a sensor calibration method for a multi-axis force torque sensor having a maximum of n axes, and being capable of measuring vertical force on n/2 axes and measuring horizontal torque on the n/2 axes, and, specifically, comprises: a first step of preparing test reference data of the multi-axis force torque sensor; a second step of obtaining sensor output values measured on the n axes provided in the multi-axis force torque sensor by using, as an input value, the test reference data prepared through the first step; a third step of calculating the linear relationship of the input value and the sensor output value on each axis for force and torque by using the sensor output values obtained through the second step; and a fourth step of calculating, on the basis of the linear relationship calculated through the third step, an input value corresponding to the sensor output value obtained through the second step, and then comparing the calculated input value to an actual input value so as to calculate a correlation determinant according to a correlation between the respective axes.

IPC Classes  ?

• G01L 25/00 - Testing or calibrating of apparatus for measuring force, torque, work, mechanical power, or mechanical efficiency
• G01L 5/16 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring several components of force
• G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
• G06F 17/10 - Complex mathematical operations

Abstract

The present invention relates to a wire-based variable link robot manipulator, which can have an expanded work area through a change in link length, can be miniaturized, and uses a wire-based actuator during implementation of a link length-adjustable mechanism so as to reduce the weight of a link and, simultaneously, reduce the required torque of a motor by reducing the weight of the link, and structurally comprises: a first link unit (100) formed of a first body (110) and a second body (120); a second link unit (200) formed of a first body (210) and a second body (220); a third body (300) coupled to the first link unit (100); and a base (600) for supporting the first link unit (100) and the second link unit (200), wherein the first link unit (100) and the second link unit (200) are adjusted in length through the driving of a wire (530), a wire (540) and a wire (570).

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/00 - Programme-controlled manipulators

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating inflammatory skin diseases, comprising, as an active ingredient, an Oryza Sativa bran and rice bran extract derived from a CNDH106 rice variety. It has been identified that the Oryza Sativa bran and rice bran extract derived from a CNDH106 rice variety containing large amounts of chrysoeriol-7 and cochlioquinone-9 through artificial crossbreeding exhibits anti-inflammatory activity in human keratinocytes (HaCaT cells), and thus the present invention can be effectively used as a composition for preventing, treating or alleviating inflammatory skin diseases.

IPC Classes  ?

• A61K 36/899 - Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• A61P 17/00 - Drugs for dermatological disorders
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A61K 8/9794 - Liliopsida [monocotyledons]
• A61Q 19/00 - Preparations for care of the skin
• A01H 6/46 - Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
• A01H 5/10 - Seeds

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel disease, comprising, as an active ingredient, an Oryza Sativa bran and rice bran extract derived from a CNDH106 rice variety. It has been identified that the Oryza Sativa bran and rice bran extract derived from a CNDH106 rice variety containing large amounts of chrysoeriol-7 and cochlioquinone-9 through artificial crossbreeding exhibits anti-inflammatory activity in colon cells (caco-2 cells), and thus the present invention can be effectively used as a composition for preventing, treating or alleviating inflammatory bowel disease.

IPC Classes  ?

• A61K 36/899 - Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

The present invention relates to a composition for preventing or treating neurodegenerative diseases or depression, comprising ASM protein or a fragment thereof and, more particularly, to a pharmaceutical or food composition comprising ASM protein or a fragment thereof that exhibits a therapeutic effect on neurodegenerative diseases or depression by inhibiting the activity of ASM protein in plasma.

IPC Classes  ?

• A61K 38/46 - Hydrolases (3)
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/24 - Antidepressants
• A23L 33/17 - Amino acids, peptides or proteins

Abstract

Provided are silica-coated cellulose nanofibers modified with a hydrophobic group capable of improving the mechanical properties of a pressure-sensitive adhesive while maintaining the adhesive performance of the pressure-sensitive adhesive; and a pressure-sensitive adhesive including the same.

IPC Classes  ?

• C08J 7/04 - Coating
• C09J 7/38 - Pressure-sensitive adhesives [PSA]
• C09J 11/08 - Macromolecular additives

Abstract

The present disclosure relates to a membrane filter for water and wastewater treatment including a membrane filter, hydrophilic polymers formed on the membrane filter; and quorum quenching microorganisms cross-linked with the membrane filter by the hydrophilic polymer. The quorum quenching microorganisms are attached to the surface of the membrane filter for water and wastewater treatment, resulting in a higher initial permeation pressure than a conventional membrane, but the quorum quenching microorganisms may effectively prevent the phenomenon of quorum sensing, allowing the formation of a biofilm, thereby improving the life of the membrane filter for water and wastewater treatment.

IPC Classes  ?

• B01D 65/08 - Prevention of membrane fouling or of concentration polarisation
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 3/12 - Activated sludge processes
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used

Abstract

The present invention relates to a biomarker composition for the diagnosis of liver diseases. It has been confirmed that Lrg1 increases in cases of liver fibrosis, indicating that Lrg1 can be utilized for the diagnosis of liver diseases, including liver fibrosis. Furthermore, the potential of Lrg1 as a therapeutic target for liver diseases has been identified, allowing its use in the prevention or treatment of liver diseases.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

Dillenia indicaDillenia indica L. extract as an active ingredient. The skin improvement composition comprising a Dillenia indica L. extract as an active ingredient according to the present invention has excellent antioxidant effects, autophagy activity increasing effects, and melanin production inhibitory effects. Accordingly, the Dillenia indica L. extract according to the present invention can be useful as a cosmetic composition for skin improvement or a functional health food composition.

IPC Classes  ?

• A61K 8/9789 - Magnoliopsida [dicotyledons]
• A61K 8/63 - SteroidsDerivatives thereof
• A61Q 19/00 - Preparations for care of the skin
• A61Q 19/08 - Anti-ageing preparations
• A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

The present invention relates to a biomarker composition for diagnosing liver disease. When RUNX3 was knocked out specifically in liver sinusoidal endothelial cells and vascular endothelial cells, an increase of the inflammatory cytokines IL-6, MCP-1, TNFa, and the like was confirmed, and an increase of angiogenesis and dysfunction of vascular endothelial cells in the liver were confirmed, and thus RUNX3 may be used for the prevention or treatment of hepatitis and liver disease.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

Disclosed is use of an antibody or antigen-binding fragment thereof that specifically binds to an acid sphingomyelinase (ASM) protein, wherein the antibody or antigen-binding fragment thereof specifically binds to an ASM protein with high binding affinity, significantly inhibits the activity of an ASM protein present in the cellular membrane, and shows effects of improving cognitive memory, inhibiting ASM protein activity, inhibiting the accumulation of amyloid-β and tau proteins, and inhibiting the production of neuroinflammation even without toxicity in Alzheimer's disease animal models, and thus can be advantageously used in the treatment of a brain disease.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

There are provided a multifunctional epoxy compound obtained by modifying two or more epoxide functional groups on terminal portions of liquid crystal molecules synthesized by bonding multiple thermotropic liquid crystal materials; and a cured product produced by reacting the compound with a curing agent. The compound and the cured product enable easy interaction between liquid crystals and exhibiting high thermal conductivity. They are usable alone as a heat-dissipating polymer, or in the form of a composite material, and are applicable as a matrix resin of a composite material.

IPC Classes  ?

• C08G 59/22 - Di-epoxy compounds
• C07D 303/18 - Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
• C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C08G 59/50 - Amines
• C08L 63/00 - Compositions of epoxy resinsCompositions of derivatives of epoxy resins

Abstract

An artificial intelligence model system for predicting solar power generation on the basis of multiple data according to the present invention comprises: an input module that receives an input of numerical data including power generation amount information and weather information and a satellite image of a region where a solar power station is installed; a controller that configures a target area and a peripheral area in a cloud satellite image and a dust satellite image included in the satellite image; an image processing module that synthesizes the target area and the peripheral area and performs image deep learning to learn spatial information, and performs deep learning by using a CNN-LSTM combined neural network to learn spatiotemporal information; a numerical weather prediction module that performs deep leaning of the numerical data by using an LSTM neural network to learn temporal information; and an artificial intelligence model that performs deep learning by using result data of deep learning and predicts the power generation amount of the solar power station.

IPC Classes  ?

• H02S 50/00 - Monitoring or testing of PV systems, e.g. load balancing or fault identification
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/0442 - Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
• G06N 3/045 - Combinations of networks
• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks
• G06N 3/08 - Learning methods
• G06T 9/00 - Image coding
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction

Abstract

Disclosed is an apparatus for continuous spinning of coagulative polymeric microfibers comprising an outer microcatheter, an inner microcatheter having a smaller diameter than the outer microcatheter and inserted inside the outer microcatheter, a double lumen part in which the outer microcatheter and the inner microcatheter are coaxially superimposed with a radially spaced interstitial space, and a single lumen part formed by the outer microcatheter from an end of the inner microcatheter to an end of the outer microcatheter. A core fluid supplied through an interior of the inner microcatheter comprises a coagulative polymeric fluid, and a sheath fluid supplied through the interstitial space comprises a fluid including saline, wherein the core fluid and the sheath fluid may be configured to flow coaxially in the single lumen part to generate and discharge a coagulative polymeric microfiber.

IPC Classes  ?

• D01D 5/28 - Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operationSpinnerette packs therefor
• A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
• A61M 25/00 - CathetersHollow probes
• D01D 4/02 - Spinnerettes
• D01D 5/06 - Wet spinning methods

Abstract

The present invention relates to a composition for preventing, alleviating or treating sarcopenia, containing a low-molecular-weight collagen as an active ingredient, and the low-molecular-weight collagen of the present invention inhibits muscle protein breakdown and can exhibit a muscle-strengthening effect through an increase in muscle mass, and thus is expected to be effectively usable for preventing, alleviating or treating sarcopenia.

IPC Classes  ?

• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

Disclosed are a high electron mobility transistor and a method for manufacturing the high electron mobility transistor. The high electron mobility transistor may comprise: a buffer layer; a channel layer formed on the buffer layer; an interlayer formed on the channel layer; a barrier layer formed on the interlayer; a source electrode formed in contact with the barrier layer; a drain electrode formed in contact with the barrier layer and spaced apart from the source electrode; a single crystal layer formed, between the source electrode and the drain electrode, on the barrier layer; and a gate electrode formed on the single crystal layer.

IPC Classes  ?

• H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
• H01L 29/66 - Types of semiconductor device
• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds

Abstract

There are provided a compound having a thermotropic liquid crystalline structure and a polyethylene glycol polymer. The compound is obtained by modifying an epoxide functional group in a thermotropic liquid crystalline molecule. The polyethylene glycol polymer is obtained by ring-opening polymerization thereof. The polyethylene glycol main chain polymer is easy to form in thin film, bulk, or fiber form, and has a high thermal conductivity and thus can be used alone or in the form of a composite material as a heat-dissipating polymer.

IPC Classes  ?

• C09K 19/12 - Non-steroidal liquid crystal compounds containing at least two non-condensed rings containing at least two benzene rings at least two benzene rings directly linked, e.g. biphenyls
• C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
• C09K 19/20 - Non-steroidal liquid crystal compounds containing at least two non-condensed rings containing at least two benzene rings linked by a chain containing carbon and oxygen atoms as chain links, e.g. esters
• C09K 19/34 - Non-steroidal liquid crystal compounds containing at least one heterocyclic ring

Abstract

The present invention relates to a technical idea of three-dimensional quantitative magnetic resonance imaging for precisely measuring cerebral oxygen metabolism and, more particularly, to a technology for quantitative magnetic resonance imaging which enables measurement of cerebral oxygen metabolism to be precisely performed in three dimensions throughout the entire brain region by using multi-echo ultrashort echo-time (UTE)-alternating unbalanced SSFP-FID & SSFP-ECHO (AUSFIDE) image data, a plurality of pieces of measurement data to be pre-processed, and separately acquired cerebral blood volume information data. The magnetic resonance imaging device according to one embodiment of the present invention may comprise: a data acquisition unit configured to acquire ultrashort echo-time (UTE)-alternating unbalanced SSFP-FID & SSFP-ECHO (AUSFIDE) image data, velocity-selective venous spin labeling (VS-VSL) image data, and pseudo-continuous arterial spin labeling (pCASL) image data; a data preprocessing unit configured to process a plurality of pieces of preliminary information data for quantitative model processing, on the basis of the acquired ultrashort echo-time (UTE)-alternating unbalanced SSFP-FID & SSFP-ECHO (AUSFIDE) image data and the acquired velocity-selective venous spin labeling (VS-VSL) image data, and to process cerebral blood flow (CBF) information data on the basis of the acquired pseudo-continuous arterial spin labeling (pCASL) image data; a quantitative model processing unit configured to acquire variable information (Yv) for inducing oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in order to acquire a three-dimensional oxygen metabolic rate map for the entire brain by using the plurality of pieces of processed preliminary information data; and an image generation unit configured to induce the oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) by using the acquired variable information to generate a magnetic resonance image from the oxygen metabolic rate map image.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

The present invention relates to a composition for single-cell proteomics analysis, a sample treatment method using same, and a method for unifying the labeling of ultra-small amounts of peptides. Particularly, the present invention relates to: a sample pretreatment composition for quantitative protein analysis, the sample pretreatment composition comprising a sulfobetaine-based amphoteric surfactant and N,N,N',N-tetrakis(2-hydroxypropyl)ethylenediamine as active ingredients; a sample pretreatment tube for quantitative protein analysis using the sample pretreatment composition, in which a centrifugal separation tube is equipped with a thin film having a plurality of micro through-holes; and a method for unifying and preparing a sample for quantitative protein analysis, the method comprising the steps of injecting a biological sample into micro through-holes provided in the sample pretreatment tube for quantitative protein analysis according to the present invention, treating the micro through-holes with the sample pretreatment composition for quantitative protein analysis, the sample pretreatment composition comprising a sulfobetaine-based amphoteric surfactant and N,N,N',N-tetrakis(2-hydroxypropyl)ethylenediamine as active ingredients, and allowing a reaction to occur, and when the reaction is completed, centrifuging the sample pretreatment tube in a centrifuge to obtain a pretreated sample collected at the bottom of the tube.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 30/72 - Mass spectrometers
• G01N 1/28 - Preparing specimens for investigation

Abstract

The present invention relates to use of an odorant receptor for suppressing the lactate-induced M2-type differentiation of tumor-associated macrophages and tumor growth. In particular, the inventors of the present invention assumed that lactate-activated OR Olfr78 would function as a macrophage lactate sensor, and confirmed whether Olfr78 on bone marrow-derived macrophages (BMDMs) detect tumor-derived lactate and lactate-induced M2 polarization. The inventors of the present invention attempted to identify factors detected by Olfr78 in tumor conditioned media (TCM), and discovered that lactate in TCM and acetic acid under some conditions are major factors involved in Olfr78-mediated generation of tumor-friendly M2-TAMs. Finally, it was found that Olfr78 deficiency inhibited tumor progression and metastasis and improved antitumor immunity in vivo (in vivo). According to the present invention, Olfr78-lactate interaction plays a major role in tumor progression, and thus, targeting of the Olfr78-lactate axis can be effectively used in targeted cancer therapy.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to a benzimidazolylurea derivative and a pharmaceutical use thereof. The benzimidazolylurea derivative exhibits excellent effects in treating and preventing pathological symptoms caused by excessive glucocorticoids by inhibiting adrenal corticosteroid production and cholesterol biosynthesis and can be used for the prevention and treatment of endogenous hypercortisolism.

IPC Classes  ?

• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 5/38 - Drugs for disorders of the endocrine system of the suprarenal hormones
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a contaminated groundwater treatment method using Capsosiphon fulvescens-based biochar, the method treating contaminated materials through the activation of persulfate by using Capsosiphon fulvescens-based biochar as a catalyst.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• B01J 21/18 - Carbon
• C02F 101/30 - Organic compounds
• C02F 101/10 - Inorganic compounds

Abstract

The present invention relates to a composition for inhibiting skin pigmentation through enhanced autophagy activity, comprising procyanidin A2 and quercetin as active ingredients. The combination of procyanidin A2 and quercetin compounds not only inhibits tyrosinase but also increases autophagy activity, thus showing remarkable effectiveness in inhibiting melanin synthesis. Therefore, this composition can be advantageously used in various materials, including food products, cosmetic compositions, and pharmaceutical compositions, associated with skin pigmentation.

IPC Classes  ?

• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61P 17/00 - Drugs for dermatological disorders
• A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin

Abstract

The present invention relates to a composition for bone regeneration, comprising: a biodegradable synthetic polymer; a biocompatible polymer compound including catechol groups; a collagen; and a bioactive substance, and provides a bone-regeneration scaffold including the composition for bone regeneration.

IPC Classes  ?

• A61L 27/26 - Mixtures of macromolecular materials
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/24 - Collagen
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• C08B 37/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C08L 89/00 - Compositions of proteinsCompositions of derivatives thereof

Abstract

The present invention relates to a rotational joint device for driving a wearable robot cable, the device being improved such that only one motor is used to bidirectionally drive a joint cable and torque can be amplified through repeated routing applied to a rolling joint. The present invention provides the rotational joint device for driving a wearable robot cable, comprising: a base; a joint part provided at the base; a link member provided to be linked to the joint part; a driving cable of which one side is connected to the link member so that the link member is driven; and a cable driving part to which the other side of the driving cable is connected so that the driving cable is driven, thereby allowing the link member to be driven.

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/00 - Programme-controlled manipulators

Abstract

The present invention relates to a docking method by which an unmanned moving body located in a mission area moves to a docking area to be docked, the method including the steps in which: a docking station located in the docking area measures a signal transmitted or received through wireless communication with the unmanned moving body and calculates a measurement value; the unmanned moving body generates a docking path on the basis of the measurement value; and the unmanned moving body is docked to the docking station on the basis of the docking path. As such, docking of the unmanned moving body to the docking station can be possible using low power and low cost while being less affected by the environment.

IPC Classes  ?

• G05D 1/20 - Control system inputs
• G01S 11/06 - Systems for determining distance or velocity not using reflection or reradiation using radio waves using intensity measurements
• G01S 11/02 - Systems for determining distance or velocity not using reflection or reradiation using radio waves

Abstract

Disclosed are a person distinguishing apparatus using a photoplethysmography (PPG) signal, and a method therefor, the apparatus using a PPG signal mainly used for pulse or blood oxygen saturation measurement or the like in daily life, so as to distinguish a person. The person distinguishing apparatus using a PPG signal comprises: a recurrence plot conversion unit using a wearable device so as to convert, into a recurrence plot (RP), a PPG signal measured during daily life; and a deep learning processing unit training a 2D convolutional neural network (CNN) model with an image converted into the RP, so as to make an inference about a person. Therefore, a method for utilizing daily-life biometric data including various noises and situations is provided, and thus, during telemedicine, data can be collected and analyzed and, simultaneously, a person can be distinguished.

IPC Classes  ?

• G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

A crane system for fall prevention and position following of an object to be moved, according to the present invention, may comprise: a top support frame horizontally positioned above the top of an object to be moved; a tilt sensor attached to the object to be moved, so as to sense the tilt of the object to be moved; a towing connection member for connecting the top support frame and the object to be moved; a towing motor, which pulls the towing connection member so as to upwardly tow the object to be moved; and a control device, which drives the towing motor so as to upwardly tow, to a first predetermined height, the object to be moved, if the tilt of the object to be moved, detected through the tilt sensor, is a predetermined angle or greater.

IPC Classes  ?

• B66C 13/48 - Automatic control of crane drives for producing a single or repeated working cycleProgramme control
• B66C 13/46 - Position indicators for suspended loads or for crane elements
• B66C 15/00 - Safety gear

Abstract

The present invention relates to a composition for preventing, treating or alleviating fatty liver or obesity, comprising an extract of Crataegus pinnatifida Bunge roots. The present inventors identified that the extract of Crataegus pinnatifida Bunge roots effectively inhibits preadipocyte cell differentiation without cytotoxicity, reduces lipid accumulation in adipocytes, and inhibits the expression of a transcription factor or adiponectin, which is involved in the formation and differentiation of adipocytes. In addition, an adiposis inhibitory effect and the effect of alleviating liver damage caused by high-fat feeding has been identified in high-fat diet mice, and it has been identified that adipogenesis and lipid accumulation are inhibited in high-fat diet mice. Therefore, Crataegus pinnatifida Bunge roots of the present invention can be effectively used as a pharmaceutical composition, a health functional food and the like for preventing, treating or alleviating fatty liver of obesity.

IPC Classes  ?

• A61K 36/734 - Crataegus (hawthorn)
• A61P 3/04 - AnorexiantsAntiobesity agents
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A61K 8/9789 - Magnoliopsida [dicotyledons]
• A61Q 19/00 - Preparations for care of the skin
• A61Q 19/06 - Preparations for care of the skin for countering cellulitis
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention provides a desalination combined catalyst electrode device, which is an electrolyzer composed of anode cell/BPM/[AEM/CEM]n/BPM/cathode cell, wherein: the anode cell contains a Ni/3d transition metal composite catalyst electrode while the fraction of 3d transition metal in the electrode is 0.3 or less; n is a natural number of 1 to 5 and AEM and CEM are located alternately; and the electrolyzer has a 50% desalination time (τ1/2) of 2.2 to 6.4 hours and a specific energy consumption (SEC) of 1.79 to 7.03 kWhm-3at J = 10 mA/cm-2.　The present invention also provides a method for manufacturing a nickel transition metal composite catalyst electrode by utilizing single-step electrodeposition, the method comprising the steps of: forming a mixture solution of hydrates containing Ni and a 3d transition metal at a ratio of 1:3 to 3:1; immersing a Ni substrate in the solution, followed by cathode bias electrodeposition for 10 to 180 seconds; and anodizing, washing, and drying the electrodeposited Ni/3d transition metal double hydrate composite catalyst electrode.

IPC Classes  ?

• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
• C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection

Abstract

Disclosed are an augmented reality clinical simulation system and method for emergency response training. An augmented reality clinical simulation system for emergency response training according to one aspect of the present invention comprises: a patient device for training in which a patient condition is set; one or more trainee devices which are worn by trainees and output treatment guide information according to the patient condition in augmented reality; one or more medical support devices; and a central control device which sets the patient condition and provides the trainee devices with the treatment guide information, and which identifies the medical support devices and enables medical information or virtual medical equipment to be checked in augmented reality using the trainee devices so as to correspond to the medical support devices.

IPC Classes  ?

• G09B 9/00 - Simulators for teaching or training purposes
• G09B 7/02 - Electrically-operated teaching apparatus or devices working with questions and answers of the type wherein the student is expected to construct an answer to the question which is presented or wherein the machine gives an answer to the question presented by the student
• G06Q 50/20 - Education
• G06Q 50/10 - Services
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G02B 27/01 - Head-up displays

Abstract

A foveated near-eye display having multiple focal planes may comprise: an image-providing element that outputs a laser beam; a variable focus lens (varifocal lens) through which the laser beam is transmitted; a scanning mirror that reflects the laser beam transmitted through the variable focus lens; a main lens positioned between a user's eye and the scanning mirror; and a control unit that adjusts the angle of the scanning mirror so that the laser beam is scanned toward the main lens.

IPC Classes  ?

• G02B 27/01 - Head-up displays

Abstract

Ldd Ldd Ldd Ldd ααδδ δδ Ldd αLdd Ldd d , thereby improving the vehicle's driving stability and the reference path tracking performance.

IPC Classes  ?

• G05D 1/20 - Control system inputs
• G05D 1/00 - Control of position, course, altitude or attitude of land, water, air or space vehicles, e.g. using automatic pilots
• B25J 9/16 - Programme controls
• B60W 40/02 - Estimation or calculation of driving parameters for road vehicle drive control systems not related to the control of a particular sub-unit related to ambient conditions

Abstract

The present invention relates to a novel peptide having the effect of treating neuroinflammatory diseases, and a use thereof, and more specifically, to a novel peptide having an Lipocalin-2 (LCN2) inhibitory activity which is closely related to neuroinflammation, and a composition for preventing or treating neuroinflammatory diseases, the composition comprising the peptide.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Disclosed are an extended reality clinical simulation system and method for medical practice. The extended reality clinical simulation system for medical practice, according to an aspect of the present invention, comprises: a patient device for practice in which conditions of a patient are set; practitioner devices that are worn by a plurality of practitioners and output, in augmented reality, treatment guide information according to the conditions of the patient; and a central control device that sets the conditions of the patient and provides the treatment guide information to each of the practitioner devices according to a role of each practitioner.

IPC Classes  ?

• G09B 9/00 - Simulators for teaching or training purposes
• G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip
• G09B 23/30 - Anatomical models
• G06Q 50/20 - Education
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
• G02B 27/01 - Head-up displays
• G09B 5/06 - Electrically-operated educational appliances with both visual and audible presentation of the material to be studied
• G06Q 50/10 - Services
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms

Abstract

The present invention relates to an optical neural network device through clustered opto-electronic modules, the device having an opto-electronic module clustering structure in which N opto-electronic modules having M input terminals and M output terminals are arranged in parallel with the input terminals and the output terminals aligned in the same direction to form a (2P-1)th stack, and N+1 opto-electronic modules having M input terminals and M output terminals are arranged in parallel with the input terminals and the output terminals aligned in the same direction to form a (2P)th stack, wherein the output terminals of the opto-electronic modules forming the (2P-1)th stack are connected to the input terminals of the opto-electronic modules forming the (2P)th stack, the opto-electronic module clustering structure has (M/2)*N inputs with a left-right symmetrical structure and (M/2)*N outputs with a left-right symmetrical structure, and the opto-electronic modules in each stack transmit, to the output terminal, an optical signal input through the input terminal, and perform any one of transmission processes among transmissions after branching or copying or straight connection, cross connection or full connection and weight calculation.

IPC Classes  ?

• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means

Abstract

The present disclosure relates to a composition for skin whitening containing a Nypa fruticans extract as an active ingredient. The composition has an effect of reducing melanin content and inhibiting melanogenesis, and enhances a skin whitening effect by enhancing autophagy activity, and thus can be used in a cosmetic composition, a health functional food composition, and a pharmaceutical composition.

IPC Classes  ?

• A61K 8/9794 - Liliopsida [monocotyledons]
• A61K 36/889 - Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
• A61P 17/00 - Drugs for dermatological disorders
• A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin

Abstract

The present invention relates to an electrical stimulation system for improving vertebral synostosis, comprising: a spinal cage formed of a porous structure having closed front and rear surfaces and inserted between the vertebrae of a user to deliver electrical stimulation to the user; and a power supply device for transmitting wireless power to generate electrical stimulation in the spinal cage, the power supply device having a form wearable by the user. Through the system, the user's vertebral synostosis can be improved.

IPC Classes  ?

• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
• A61N 1/378 - Electrical supply
• A61N 1/375 - Constructional arrangements, e.g. casings
• A61N 1/372 - Arrangements in connection with the implantation of stimulators
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• A61F 2/44 - Joints for the spine, e.g. vertebrae, spinal discs

Abstract

The present invention relates to a composition including catechin hydrate as an active ingredient for the prevention, alleviation, or treatment of chronic obstructive pulmonary disease. The catechin hydrate of the present invention significantly inhibits fine dust-induced cell apoptosis in human bronchial epithelial cells, restores mitochondrial function, and suppresses lung damage, and thus can be effectively used in a composition for the prevention, alleviation, or treatment of chronic obstructive pulmonary diseases such as emphysema, chronic bronchitis, asthma, or pneumonia.

IPC Classes  ?

• A61K 36/65 - Paeoniaceae (Peony family), e.g. Chinese peony
• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61P 11/00 - Drugs for disorders of the respiratory system
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

Provided are a method and device for estimating the GPS coordinates of multiple target objects and tracking the target objects on the basis of camera image information from an unmanned aerial vehicle according to an embodiment. The device comprises: a detection unit that, through a pre-trained artificial intelligence deep learning model, detects an object corresponding to an assignment set in the unmanned aerial vehicle, and generates a bounding box including the detected target object according to the size of the target object; a setting unit that sets a reference pixel that is a target point represented as a pixel on a camera image plane; a calculation unit that calculates reference pixel coordinates of the target object in a two-dimensional pixel coordinate system; and a conversion unit that converts the reference pixel coordinates of the target object into three-dimensional coordinates by using at least one of altitude information about the unmanned aerial vehicle or depth information about the target object, and converts the coordinate system of the converted three-dimensional coordinates to acquire the GPS coordinates of the target object.

IPC Classes  ?

• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06T 7/55 - Depth or shape recovery from multiple images
• G06T 3/00 - Geometric image transformations in the plane of the image
• G06N 3/08 - Learning methods
• G05D 1/00 - Control of position, course, altitude or attitude of land, water, air or space vehicles, e.g. using automatic pilots
• G05D 1/20 - Control system inputs
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use

Abstract

The present invention relates to a composition for preventing, alleviating or treating sarcopenia, containing D-ribo-2-hexulose as an active ingredient. D-ribo-2-hexulose of the present invention is a sweetener capable of replacing sugar, is harmless to the human body and does not cause side effects in normal cells so as to be safe for the human body, inhibits the degradation of myoproteins, and can exhibit muscle strengthening effects by increasing muscle mass, and thus the present invention is expected to be effectively usable in the prevention, alleviation or treatment of sarcopenia.

IPC Classes  ?

• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

The present invention relates to a composition for improving bone function comprising sericin, and use thereof. The sericin of the present invention is a protein derived from a natural material, and thus not only is safe, has less denaturation, and is biocompatible, but is also excellent for improving bone function. In particular, a drink-type health functional food for improving bone function comprising the sericin of the present invention as an active ingredient solves the inconvenience of treatment methods compared to existing injectable or tablet therapeutic agents as preparations for improving bone function and curing bone disease damage, and can not only be a great alternative to the existing injectable or tablet therapeutic agents, but also can contribute to economic growth and social benefits by recycling sericin that is discarded as a by-product of silk protein.

IPC Classes  ?

• A23L 33/17 - Amino acids, peptides or proteins
• A23L 2/38 - Other non-alcoholic beverages
• A23K 10/20 - Animal feeding-stuffs from material of animal origin
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 35/64 - Insects, e.g. bees, wasps or fleas
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

A system for diagnosing a machine failure according to an embodiment of the inventive concept includes a pre-processing module that receives a primitive signal in a time-amplitude domain to generate a Mel spectrum image in a time-frequency domain, a feature extraction module that learns features of the Mel spectrum image to output an Euclidean distance between a latent variable and a centroid, a failure diagnosis module that performs classification into a preset number of classes on the basis of the Euclidean distance between the latent variable and the centroid, and a result output module that outputs whether a failure has occurred according to a class classified by the failure diagnosis module.

IPC Classes  ?

• G01M 99/00 - Subject matter not provided for in other groups of this subclass
• G05B 23/02 - Electric testing or monitoring

Abstract

The present invention relates to a method for forming a three-dimensional structure by using UV parallel light in a multilayered stacked structure, and a three-dimensional structure formed by the method, and, specifically, to: a method, which emits parallel light and UV light at a photomask so as to use UV parallel light in an improved multilayered stacked structure having the effects of impact resistance, resilience, elongation, and low-reflective coating, thereby forming a three-dimensional structure; a three-dimensional structure formed by the method; and an element employing the three-dimensional structure. The three-dimensional structure according to a manufacturing method of the present invention comprises an impact-absorption layer skeleton support and an impact cushioning part in the vicinity of the skeleton support that each have a different modulus value. The skeleton support maintains high hardness of the structure and the impact cushioning part distributes internal/external impact, and thus a three-dimensionally shaped impact-absorption layer having excellent impact resistance, resilience, and elongation can be manufactured. The impact-absorption layer can also be used in a stacked structure and an element that employs the stacked structure.

IPC Classes  ?

• H10K 77/10 - Substrates, e.g. flexible substrates
• H10K 71/00 - Manufacture or treatment specially adapted for the organic devices covered by this subclass
• G09F 9/30 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements
• H10K 102/00 - Constructional details relating to the organic devices covered by this subclass

Abstract

The present invention pertains to a novel compound derivative and a pharmacological use thereof and specifically to a novel 1,1-dioxo-1,2-benzisothiazole derivative or novel 3-citryl-1H-pyrazole derivatives possessing antiplatelet activity, and a pharmaceutical use thereof. The 1,1-dioxo-1,2-benzisothiazole derivative or 5-amino-3-(1-cyano-2-(3,4,5-trimethoxyphenyl)vinyl)-1H-pyrazole-4-carbonitrile according to the present invention can suppress the activation of glycoprotein (GP) IIb/IIIa to inhibit platelet aggregation, thereby demonstrating potential prophylactic, ameliorative, or therapeutic effects against thrombotic diseases and cardiovascular disorders.

IPC Classes  ?

• A61K 31/415 - 1,2-Diazoles
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• C07D 275/06 - Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a COX2 acetylating agent as an active ingredient and, more particularly, to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising, as an active ingredient, a COX2 acetylating agent which exhibits an effect of inhibiting the deposition of amyloid-β in brain neurons, reducing excessive neuroinflammatory responses, and increasing the phagocytosis of amyloid-β in microglial cells. The pharmaceutical composition for preventing or treating neurodegenerative diseases comprising the COX2 acetylating agent as an active ingredient has the effects of alleviating neuroinflammation by promoting COX2 acetylation in neurons and secreting specialized pro-resolving mediators (SPMs) and thus, can be very useful in the development of a preventive or therapeutic agent for neurodegenerative diseases.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes

Abstract

Proposed are a complex catalyst containing an imine-based ligand for polymerizing a cyclic olefin-based monomer and a method of preparing a cyclic olefin-based polymer using the same. More particularly, proposed are a complex catalyst containing an imine-based ligand for polymerizing a cyclic olefin-based monomer, which can provide the complex catalyst containing the imine-base ligand having high activity in polymerizing the cyclic olefin-based monomer and can prepare a cyclic olefin-based polymer with high activity by polymerizing the cyclic olefin-based monomer in the presence of the complex catalyst containing the imine-based ligand, and a method of preparing a cyclic olefin-based polymer using the same.

IPC Classes  ?

• C08F 32/08 - Homopolymers or copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings
• C08F 2/06 - Organic solvent
• C08F 4/70 - Iron group metals, platinum group metals, or compounds thereof

Abstract

A method for manufacturing an eco-friendly capsule includes: disposing a water phase material containing chitosan at a first site, and disposing an oil phase material at a second site and a third site, on a microfluidic chip; moving the water phase material and the oil phase material to a reaction site according to a predetermined flow ratio to produce an emulsion containing droplets having a predetermined diameter; mixing the emulsion with a water phase solution in a mixing tank; and producing chitosan beads by the reaction of the emulsion with the water phase solution.

IPC Classes  ?

• A01N 25/28 - Microcapsules
• A01N 25/10 - Macromolecular compounds
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• B01J 13/18 - In situ polymerisation with all reactants being present in the same phase
• B01J 13/20 - After-treatment of capsule walls, e.g. hardening

Abstract

A voice recognition device of the present invention may comprise: a first pre-learning unit, which uses a first artificial intelligence model so as to extract a first feature expression from learning voice data; a second pre-learning unit, which uses a second artificial intelligence model so as to extract a second feature expression from the first feature expression; and a voice recognition unit, which uses a third artificial intelligence model so as to extract predictive text from the second feature expression.

IPC Classes  ?

• G10L 15/26 - Speech to text systems
• G10L 15/06 - Creation of reference templatesTraining of speech recognition systems, e.g. adaptation to the characteristics of the speaker's voice
• G10L 15/02 - Feature extraction for speech recognitionSelection of recognition unit
• G10L 15/16 - Speech classification or search using artificial neural networks
• G10L 25/18 - Speech or voice analysis techniques not restricted to a single one of groups characterised by the type of extracted parameters the extracted parameters being spectral information of each sub-band
• G10L 15/183 - Speech classification or search using natural language modelling using context dependencies, e.g. language models
• G06N 20/00 - Machine learning

Abstract

The present invention relates to a composition for treating a cancer disease, comprising an extracellular vesicle derived from natural killer cells with surface expression of cytokine and an antibody. By expressing IL-15 and a cancer cell-specific antibody on the surface of human natural killer cells, it is possible to provide an extracellular vesicle that can exhibit strong cytotoxic activity specifically against cancer cells. The extracellular vesicle can be provided as a new anticancer agent that is safe for the human body and exhibits an excellent anticancer effect. In addition, the extracellular vesicle of the present invention can be used to deliver drugs or bioactive substances to specific cancer cells by encapsulating the drugs or bioactive substances having a therapeutic effect on cancer therein, and thus can be provided as a new means of treating cancer.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/20 - Interleukins
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 9/50 - Microcapsules
• A61P 35/00 - Antineoplastic agents
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a screening method for a therapeutic agent for vascular calcification, in which it was confirmed that, in a CaBP9K-deletion model among vascular-calcification-induced animal models, vascular calcification was ameliorated, compared to a normal model, and thus the screening method is useful as a method for screening for a composition for the prevention, treatment, amelioration, or diagnosis of vascular calcification, or for a therapeutic agent for vascular calcification.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material
• G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• A61B 6/03 - Computed tomography [CT]
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

The present invention relates to a polysubstituted imidazolo[4,5-c][1,2]thiazine derivative and a use of an agent comprising same as an active agent, which is useful for infectious diseases associated with vascular inflammation caused by HMGB1 protein activity. It has been found that the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative of the present invention increases the sepsis survival rate as a result of searching for antiseptic effects through CLP-induced sepsis animal experiments. Accordingly, the agent comprising the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative or a pharmaceutically acceptable salt thereof as an active agent may be advantageously used as a therapeutic agent for infectious diseases and vascular inflammatory diseases including sepsis caused by HMGB1 protein activity.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics