Roche Holding AG

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C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants 1,560
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A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum 1,336
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C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids 724
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1.

OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS

      
Application Number 18985661
Status Pending
Filing Date 2024-12-18
First Publication Date 2025-04-17
Owner Genentech, Inc. (USA)
Inventor
  • Terrett, Jack Alexander
  • Chen, Huifen
  • Constantineau-Forget, Lea
  • Larouche-Gauthier, Robin
  • Lépissier, Luce
  • Beaumier, Francis
  • Déry, Martin
  • Grand-Maître, Chantal
  • Sturino, Claudio
  • Volgraf, Matthew
  • Villemure, Elisia

Abstract

The invention relates to compounds of formula I: The invention relates to compounds of formula I: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

IPC Classes  ?

  • C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
  • A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
  • A61P 11/00 - Drugs for disorders of the respiratory system
  • A61P 23/00 - Anaesthetics
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
  • C07D 471/04 - Ortho-condensed systems
  • C07D 473/30 - Oxygen atom attached in position 6, e.g. hypoxanthine
  • C07D 487/04 - Ortho-condensed systems
  • C07D 498/04 - Ortho-condensed systems
  • C07D 513/04 - Ortho-condensed systems

2.

AN IVA TEST UNIT, A TEST SET COMPRISING THE IVA TEST UNIT AND A METHOD OF PRODUCING THE SAME

      
Application Number EP2024078092
Publication Number 2025/078295
Status In Force
Filing Date 2024-10-07
Publication Date 2025-04-17
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • ROCHE DIAGNOSTICS GMBH (Germany)
  • ROCHE DIAGNOSTICS OPERATIONS, INC. (USA)
Inventor
  • Blum, Martin
  • Isgoeren, Yilmaz
  • Meyer Dos Santos, Sascha

Abstract

IVA test unit (1) comprising: a test strip (2) for detecting an analyte, wherein the test strip comprises at least an application function, a test reaction function and a test detection function; and a housing (3) for storing the test strip (2) wherein the housing (3) comprises an insert tray (4) and an insert hole (5) for inserting the test strip (2) into the insert tray (4), characterized in that the housing (3) is formed as one single piece.

IPC Classes  ?

3.

COLLABORATION PLATFORM FOR ANALYZING LARGE PRIVACY-IMPACTED DATASETS

      
Application Number US2024050537
Publication Number 2025/080684
Status In Force
Filing Date 2024-10-09
Publication Date 2025-04-17
Owner
  • ROCHE MOLECULAR SYSTEMS, INC. (USA)
  • ROCHE SEQUENCING SOLUTIONS, INC. (USA)
Inventor
  • Dallett, Carolina
  • Huensche, Arick
  • Sankarlingam, Victor Sundaram
  • Utiramerur, Sowmithri

Abstract

A collaboration platform is provided to analyze one or more biomedical data sets. The collaboration platform may include a project management engine, a data ingestion engine, and a data analysis engine. The project management engine may generate a plurality of project environments for analyzing biomedical data sets of interest, and designate a set of authorized users with access to given project environments. The data ingestion engine may process data sets and store them in a central data storage system for access within the project environments. The data analysis engine may perform analyses and special computing on the ingested data and generate updated output data that may be re-ingested for further analyses in the project environments.

IPC Classes  ?

  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

4.

COMBINATION THERAPY WITH AN ANTI-HER2 ANTIBODY-DRUG CONJUGATE AND A BCL-2 INHIBITOR

      
Application Number 18984106
Status Pending
Filing Date 2024-12-17
First Publication Date 2025-04-17
Owner GENENTECH, INC. (USA)
Inventor
  • Phillips, Gail Lewis
  • Sampath, Deepak
  • Wertz, Ingrid

Abstract

The present invention is directed to a combination therapy involving an anti-HER2 antibody-drug conjugate and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a HER2-expressing cancer.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
  • A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • A61P 35/00 - Antineoplastic agents
  • C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

5.

Subcutaneous anti-HER2 Antibody Formulations and Uses Thereof

      
Application Number 18991315
Status Pending
Filing Date 2024-12-20
First Publication Date 2025-04-17
Owner Genentech, Inc. (USA)
Inventor
  • Adler, Michael
  • Grauschopf, Ulla
  • Mahler, Hanns-Christian
  • Stauch, Oliver Boris

Abstract

The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/08 - Solutions
  • A61K 9/19 - Particulate form, e.g. powders lyophilised
  • A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
  • A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
  • A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
  • C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes

6.

Anti-Polyubiquitin Multispecific Antibodies

      
Application Number 18983995
Status Pending
Filing Date 2024-12-17
First Publication Date 2025-04-17
Owner Genentech, Inc. (USA)
Inventor
  • Dixit, Vishva
  • Matsumoto, Marissa
  • Castellanos, Erick

Abstract

The invention provides antibodies that bind mixed-topology polyubiquitin and multispecific anti-polyubiquitin antibodies, and methods of using the same.

IPC Classes  ?

  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C12N 15/62 - DNA sequences coding for fusion proteins
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

7.

ANTI-Ly6E ANTIBODIES, IMMUNOCONJUGATES, AND USES THEREOF

      
Application Number 18927265
Status Pending
Filing Date 2024-10-25
First Publication Date 2025-04-17
Owner Genentech, Inc. (USA)
Inventor
  • Agard, Nicholas John
  • Pillow, Thomas Harden
  • Dela Cruz Chuh, Josefa
  • Go, Mary Ann T.
  • Kozak, Katherine R.
  • Lin, Zhonghua
  • Seshasayee, Dhaya
  • Yu, Shang-Fan
  • Koerber, James Thomas
  • Sun, Yonglian

Abstract

The invention provides anti-Ly6E antibodies and immunoconjugates, and methods of using the same.

IPC Classes  ?

  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
  • A61P 35/00 - Antineoplastic agents
  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

8.

ELUTION KIT, ANALYTICAL KIT AND METHOD OF ELUTING AND ANALYZING A BIOLOGICAL SAMPLE

      
Application Number EP2024078090
Publication Number 2025/078294
Status In Force
Filing Date 2024-10-07
Publication Date 2025-04-17
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • ROCHE DIAGNOSTICS GMBH (Germany)
  • ROCHE DIAGNOSTICS OPERATIONS, INC. (USA)
Inventor
  • Blum, Martin
  • Isgoeren, Yilmaz
  • Meyer Dos Santos, Sascha

Abstract

An elution kit (1) for eluting a biological sample in a liquid (2) and dispensing the eluted sample liquid (2') onto a test element (102) of an analytical kit (101), the elution kit (1) comprises: a sample collection swab (3) for collecting the biological sample, wherein the sample collection swab (3) comprises a stick portion (4) for being hand-held and a deformable head portion (5) on the stick portion (4) for collecting the biological sample, wherein the head portion (5) is porous for the liquid (2); and an elution liquid tube (6) which comprises: an interior space (7) for housing the liquid (2), receiving the sample collection swab (3) and eluting the biological sample in the liquid (2); an insertion opening (10) on a first side of the interior space (7) for inserting the sample collection swab (3) into the interior space (7); a dispense opening (11) on a second side of the interior space (7) adjacent the first side for dispensing the eluted sample liquid; a first closure element (12) to seal the dispense opening (11) in a water-vapor impermeable manner; a second closure element (13) to seal the insertion opening (10) in a water-vapor impermeable manner, wherein the first closure element (12) and/or the second closure element (13) comprises a foil; and the liquid (2), wherein the elution liquid tube (6) contains the liquid (2), wherein the interior space (7) is defined by an inner surface (8) that comprises an elution zone (16) with at least one elution portion (9) having a smallest side-to-side distance y ranging between approximately 70% and 140% of a largest side-to-side distance x of the head portion (5) of the sample collection swab (3) and defining a gap (14) through which the sample collection swab (3) can be pushed and pulled in a closed state of the dispense opening (11).

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B01L 3/02 - BurettesPipettes

9.

AMPLIFICATION-FREE TARGET ENRICHMENT WORKFLOW FOR DIRECT DETECTION OF NUCLEIC ACID MODIFICATIONS

      
Application Number EP2024078789
Publication Number 2025/078657
Status In Force
Filing Date 2024-10-11
Publication Date 2025-04-17
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • ROCHE SEQUENCING SOLUTIONS, INC. (USA)
Inventor
  • Arnold, Cleoma
  • Beyer, David Charles
  • Chavan, Shivalika Shishir
  • Dhiman, Kirti
  • Franklin, Helen
  • Ho, Stanley
  • Hou, Yanli
  • Kang, Soo Jin
  • Klugherz, Spencer
  • Nelson, Christopher
  • Richmond, Todd
  • Schubert, Rajib

Abstract

The present disclosure provides methods of sequencing one or more target nucleic acid molecules, where each of the one or more target nucleic acid molecules includes one or more modified nucleotides, and wherein the method does not require conversion of any of the one or more modified nucleotides prior to sequencing, and/or does not require any amplification (PCR) cycles prior to sequencing In some embodiments, sequencing is performed with a sequencing-by-tag sequencing device. In other embodiments, sequencing is performed with a Single Molecule Real Time sequencing device.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6869 - Methods for sequencing

10.

OLIGONUCLEOTIDES FOR INDUCING PATERNAL UBE3A EXPRESSION

      
Application Number 18491513
Status Pending
Filing Date 2023-10-20
First Publication Date 2025-04-10
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Costa, Veronica
  • Hedtjärn, Maj
  • Hoener, Marius
  • Jagasia, Ravi
  • Jensen, Mads Aaboe
  • Patsch, Christoph
  • Pedersen, Lykke
  • Rasmussen, Søren Vestergaard

Abstract

The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • C12N 5/074 - Adult stem cells
  • C12N 5/0793 - Neurons
  • C12N 5/0797 - Stem cellsProgenitor cells
  • C12N 15/11 - DNA or RNA fragmentsModified forms thereof
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

11.

PROCESS FOR THE PREPARATION OF [RU(OAC)2(LIGAND)] CATALYSTS

      
Application Number 18984468
Status Pending
Filing Date 2024-12-17
First Publication Date 2025-04-10
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Puentener, Kurt
  • Trachsel, Etienne

Abstract

The invention comprises a process for the preparation of a [Ru(OAc)2(Ligand)] catalysts of the formula I The invention comprises a process for the preparation of a [Ru(OAc)2(Ligand)] catalysts of the formula I The invention comprises a process for the preparation of a [Ru(OAc)2(Ligand)] catalysts of the formula I wherein R1 is C1-6 alkyl and R3 is hydrogen or C1-6 alkyl and R4 is hydrogen or C1-6-alkoxy. The invention comprises a process for the preparation of a [Ru(OAc)2(Ligand)] catalysts of the formula I wherein R1 is C1-6 alkyl and R3 is hydrogen or C1-6 alkyl and R4 is hydrogen or C1-6-alkoxy. [Ru(OAc)2(Ligand)] catalysts are versatile hydrogenation catalysts.

IPC Classes  ?

12.

REAGENT FORMULATION FOR MASS AXIS CHECK AND ADJUSTMENT

      
Application Number 18694874
Status Pending
Filing Date 2022-09-21
First Publication Date 2025-04-10
Owner Roche Diagnostics Operations, Inc. (USA)
Inventor Lang, Robert

Abstract

The present invention relates to a composition comprising (i) cesium iodide, (ii) ethylamine and/or formic acid, and (iii) methanol and/or water. The present invention further relates to a method for calibrating a mass spectrometry (MS) device comprising (I) determining a mass spectrum of a composition as specified; and (II) calibrating the MS device based on the mass spectrum determined in step (I). The present invention further relates to devices, kits, uses, and methods related thereto.

IPC Classes  ?

13.

MEANS AND METHODS APPLYING sFlt-1/PIGF OR ENDOGLIN/PIGF RATIO TO RULE OUT ONSET OF PREECLAMPSIA WITHIN A CERTAIN TIME PERIOD

      
Application Number 18798760
Status Pending
Filing Date 2024-08-08
First Publication Date 2025-04-10
Owner Roche Diagnostics Operations, Inc. (USA)
Inventor
  • Hund, Martin
  • Schoedl, Maria

Abstract

The present invention concerns the field of diagnostic assays for prenatal diagnosis of preeclampsia. In particular, it relates to a method for diagnosing whether a pregnant subject is not at risk for preeclampsia within a short window of time comprising a) determining the amount of at least one angiogenesis biomarker selected from the group consisting of sFlt-1, Endoglin and PlGF in a sample of said subject, and b) comparing the amount with a reference, whereby a subject being not at risk for developing preeclampsia within a short period of time is diagnosed if the amount is identical or decreased compared to the reference in the cases of sFlt-1 and Endoglin and identical or increased in the case of PlGF, wherein said reference allows for making the diagnosis with a negative predictive value of at least about 98%. Further contemplates are devices and kits for carrying out said method.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

14.

CRAMMED TRAINING FOR MOLECULAR COMPUTATION MODELS

      
Application Number 18907387
Status Pending
Filing Date 2024-10-04
First Publication Date 2025-04-10
Owner Genentech, Inc. (USA)
Inventor
  • Frey, Nathan Christopher
  • Ismail, Aya Abdelsalam Attia Abdelsalam

Abstract

A method for crammed training of a molecular computation model includes receiving the molecular computation model. One or more crammed training constraints may be identified. An modification to the molecular computation model may be determined based on the one or more crammed training constraints. One or more training hyperparameters may be based on the one or more crammed training constraints. The molecular computation model having the architectural modification may be trained, or in some cases, pretrained in accordance with the one or more training hyperparameters. In some cases, the pretrained molecular computation model may undergo finetuning for a specific task such as predicting the function of a protein sequence or classifying a pair of protein sequences as an interacting pair or a non-interacting pair. Related systems and computer program products are also provided.

IPC Classes  ?

  • G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

15.

TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

      
Application Number 18985513
Status Pending
Filing Date 2024-12-18
First Publication Date 2025-04-10
Owner Genentech, Inc. (USA)
Inventor
  • Labadie, Sharada
  • Liang, Jun
  • Ortwine, Daniel Fred
  • Wang, Xiaojing
  • Zbieg, Jason
  • Zhang, Birong
  • Goodacre, Simon Charles
  • Ray, Nicholas Charles
  • Li, Jun

Abstract

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
  • A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

16.

SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY

      
Application Number 18988433
Status Pending
Filing Date 2024-12-19
First Publication Date 2025-04-10
Owner Genentech, Inc. (USA)
Inventor
  • Mcbride, Christopher
  • Trzoss, Lynnie Lin
  • Boloor, Amogh
  • Sokolova, Nadezda V.
  • Pastor, Richard M.
  • Staben, Steven Thomas
  • Stivala, Craig
  • Volgraf, Matthew
  • Bronner, Sarah M.

Abstract

The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

IPC Classes  ?

17.

METHOD FOR SCREENING A BIOLOGICAL FLUID SAMPLE FOR AN ANALYTE ASSOCIATED WITH PROTEINOPATHY USING WHITE LIGHT INTERFEROMETRY OR ATOMIC FORCE MICROSCOPY

      
Application Number EP2024078080
Publication Number 2025/073987
Status In Force
Filing Date 2024-10-04
Publication Date 2025-04-10
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Britschgi, Markus
  • Ceylan, Eylul
  • Kissling, Tom Moritz
  • Lauer, Matthias Eckhard
  • Dettinger, Philip Michael
  • Martin, Rainer Eugen
  • Wolfard, Jens André

Abstract

Disclosed herein is a device and method for measuring spatial mass distribution profiles to weigh the accumulated-aggregated mass of an analyte in a crowded bioorganic material background by employing a high frequency recognition pattern. The recognition pattern allows for the Fourier filtering of mass sensitive image data for background and noise subtraction. The device and method enables the screening of a biological fluid sample for an analyte associated with proteinopathy.

IPC Classes  ?

  • G01B 9/00 - Measuring instruments characterised by the use of optical techniques
  • G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
  • G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
  • G01Q 60/24 - AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
  • G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
  • G01Q 60/42 - Functionalisation

18.

MACHINE LEARNING ENABLED ESTIMATION OF DIFFERENCES BETWEEN PROTEIN SEQUENCES

      
Application Number US2024050017
Publication Number 2025/076393
Status In Force
Filing Date 2024-10-04
Publication Date 2025-04-10
Owner
  • GENENTECH, INC. (USA)
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Leaver-Fay, Andrew Philip
  • Lee, Edith
  • Liang, Wei-Ching
  • Lin, Yao-Yu
  • Vasilaki, Stefania
  • Pinheiro, Pedro Henrique Oliveira
  • Tagasovska, Natasa
  • Watkins, Andrew, Martin
  • Cho, Kyunghyun
  • Frey, Nathan Christopher
  • Gligorijevic, Vladimir

Abstract

A method may include generating a training dataset including a pair of sample molecules. The sample molecule pair includes a first molecule and a second molecule. A property computation model is trained to determining a sequence difference comprising a difference between an amino acid sequence of the first molecule and an amino acid sequence of the second molecule. The property computation model is further trained to generate a relative embedding representative of the sequence difference and associating the sequence difference with the sample molecule pair. The property computation model is further trained to determine, based on the relative embedding, a property difference corresponding to a difference between a value of the property exhibited by the first molecule and a value of the property exhibited the second molecule. The trained property computation model may be applied to determine a property difference of a pair of input molecules.

IPC Classes  ?

  • G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
  • G16B 40/30 - Unsupervised data analysis
  • G16B 40/20 - Supervised data analysis
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
  • G16C 20/50 - Molecular design, e.g. of drugs
  • G16C 20/70 - Machine learning, data mining or chemometrics
  • G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
  • G06N 3/08 - Learning methods
  • G06N 20/00 - Machine learning
  • G16C 20/64 - Screening of libraries
  • G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

19.

CARBAMATES FOR USE AS SARM1 INHIBITORS

      
Application Number US2024049501
Publication Number 2025/076017
Status In Force
Filing Date 2024-10-02
Publication Date 2025-04-10
Owner GENENTECH, INC. (USA)
Inventor
  • Zeng, Mingshuo
  • Zhu, Bing-Yan
  • Chan, Bryan Ka Ip
  • Del Bel, Matthew L.
  • Gazzard, Lewis J.
  • Grandner, Jessica Marie
  • Green, Samantha Alyson
  • Liang, Jun
  • Smith, Russell Tyler

Abstract

This invention relates to carbamate compounds of Formula (I), as further detailed herein, which are used for inhibition of SARM1 proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

IPC Classes  ?

  • C07D 413/08 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
  • C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
  • C07D 498/10 - Spiro-condensed systems
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
  • A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
  • A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol

20.

STRUCTURED DATA CAPTURE, AGGREGATION, AND ANALYSIS OF CLINICAL CHARACTERISTICS OF PATIENTS IN A LIVER DISEASE DIAGNOSTIC SETTING

      
Application Number US2024049241
Publication Number 2025/075908
Status In Force
Filing Date 2024-09-30
Publication Date 2025-04-10
Owner
  • ROCHE MOLECULAR SYSTEMS, INC. (USA)
  • ROCHE DIAGNOSTICS INTERNATIONAL AG (Switzerland)
Inventor
  • Bariya Shanker, Supretta Yadav
  • Chana, Ravinder
  • Hebbar, Harish
  • Narula, Ritika
  • Pabial, Ravinder
  • Palan, Mahesh
  • Pancholi, Manan Mahesh
  • Parekh, Kaushal Dilip

Abstract

A system for managing liver disease including an electronic medical record system comprising a plurality of patient records. The system includes a patient management platform configured to access the electronic medical record (EMR) system to retrieve medical records of one or more patients, analyze the medical records to selectively identify data relating to liver condition(s), interface with one or more data analytics platform(s), the data analytics platform(s) configured to receive and analyze the data relating to liver-conditions. Based on the analyzing by the patient management interface and/or the data analytics platform(s), generating a display including specific liver-related patient attributes and conditions, and at least one of a liver-health prognosis or recommended treatment for addressing the liver condition(s) respective to the one or more patients. The liver conditions may include one or more of: cancer, cirrhosis, liver failure, fatty liver disease, steatosis, ischemia, and/or hepatitis.

IPC Classes  ?

  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

21.

PYRIDINE DERIVATIVES

      
Application Number 18985716
Status Pending
Filing Date 2024-12-18
First Publication Date 2025-04-10
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Décoret, Guillaume
  • Groebke Zbinden, Katrin
  • Haap, Wolfgang
  • Kreis, Lukas
  • Lucas Cabré, Xavier
  • Rauber, Etienne

Abstract

The invention relates to a compound of formula (I) The invention relates to a compound of formula (I) The invention relates to a compound of formula (I) wherein A1, R1, R2, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
  • A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
  • C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

22.

METHODS FOR MANAGEMENT OF PROSTATE CANCER

      
Application Number 18908787
Status Pending
Filing Date 2024-10-07
First Publication Date 2025-04-10
Owner Roche Diagnostics Operations, Inc. (USA)
Inventor
  • Cobbaert, Christa
  • Kroeniger, Konstantin
  • Lageveen-Kammeijer, Guinevere
  • Nouta, Jan
  • Rolny, Vinzent
  • Ruhaak, Renee
  • Swiatek-De Lange, Magdalena
  • Tabares, Gloria
  • Van Der Burgt, Yuri
  • Wuhrer, Manfred

Abstract

The present invention relates to methods for assessing whether or not a patient has aggressive prostate cancer by determining the levels of particular glycoforms attached to prostate specific antigen (PSA) protein in a biofluid sample of a subject, and comparing the determined level or concentration to a reference. The methods are particularly useful for assessing subjects that have 2-10 ng/ml total PSA in the subject's serum.

IPC Classes  ?

  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
  • G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes

23.

THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF

      
Application Number 18985502
Status Pending
Filing Date 2024-12-18
First Publication Date 2025-04-10
Owner Genentech, Inc. (USA)
Inventor
  • Mckerrall, Steven
  • Beveridge, Ramsay
  • Lai, Kwong Wah
  • Bergeron, Philippe

Abstract

The invention provides a compound of formula (I): The invention provides a compound of formula (I): The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

IPC Classes  ?

  • C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
  • A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
  • A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

24.

TECHNIQUES FOR EVALUATING ARTIFICIAL INTELLIGENCE SYSTEMS WITHOUT GROUND-TRUTH ANNOTATIONS

      
Application Number 18910198
Status Pending
Filing Date 2024-10-09
First Publication Date 2025-04-10
Owner Flatiron Health, Inc. (USA)
Inventor
  • Kiyasseh, Dani
  • Cohen, Aaron
  • Jiang, Chengsheng
  • Altieri, Nicholas

Abstract

Disclosed systems and methods provide a framework for evaluating AI systems without ground-truth annotations. The disclosed embodiments may assign temporary labels to data points in sets of working data and use the temporarily labeled data to train one or more distinct models. These models may be evaluated to determine which has the highest performance and is thus indicative of the temporary labels most likely to be correct.

IPC Classes  ?

25.

PROCESS FOR MANUFACTURING BALOXAVIR MARBOXIL

      
Application Number EP2024077821
Publication Number 2025/073819
Status In Force
Filing Date 2024-10-03
Publication Date 2025-04-10
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Barbato, Keith Steven
  • Born, Stephen Christopher
  • Chakrabarty, Rajshree

Abstract

The invention relates to a novel process for making baloxavir marboxil (1) and baloxavir (1a), as well as to an integrated continuous manufacturing (ICM) implementation thereof. Formulae (1) and (1a), (1) and (1a).

IPC Classes  ?

26.

DRUG COMBINATIONS SCREENING

      
Application Number EP2024078058
Publication Number 2025/073970
Status In Force
Filing Date 2024-10-04
Publication Date 2025-04-10
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Baker, Mike
  • Ghazaleh, Naghmeh
  • Hayward-Koennecke, Helen Katharina
  • Overell, James
  • Saadat Varnosfaderanii, Ali
  • Thanei, Gian-Andrea

Abstract

Methods of screening drug combinations are described. The methods comprise obtaining, for a first drug and a second drug, the values of a plurality of features associated with the drug combination; and predicting, using the values of said plurality of features, the effect of the drug combination using a machine learning model that has been trained to predict whether a drug combination is likely synergistic. The plurality of features comprises at least one feature that characterises the similarity between one or more indications or diseases associated with one or more targets of the first drug and one or more indications or diseases associated with one or more targets of the second drug. Related methods, products and systems are also described.

IPC Classes  ?

  • G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures

27.

LACTAMS FOR USE AS SARM1 INHIBITORS

      
Application Number US2024049598
Publication Number 2025/076088
Status In Force
Filing Date 2024-10-02
Publication Date 2025-04-10
Owner GENENTECH, INC. (USA)
Inventor
  • Zheng, Mingshuo
  • Zhu, Bing-Yan
  • Chan, Bryan Ka Ip
  • Del Bel, Matthew L.
  • Gazzard, Lewis John
  • Grandner, Jessica Marie
  • Green, Samantha Alyson
  • Liang, Jun
  • Smith, Russell Tyler

Abstract

This invention relates to lactam compounds of Formula (I), as further detailed herein, which are used for inhibition of SARM1 proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

IPC Classes  ?

  • C07D 401/08 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
  • C07D 417/08 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing alicyclic rings
  • C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
  • A61K 31/541 - Non-condensed thiazines containing further heterocyclic rings

28.

PROCESS FOR MANUFACTURING MACROCYCLIC PEPTIDES

      
Application Number 18803333
Status Pending
Filing Date 2024-08-13
First Publication Date 2025-04-03
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Adam, Jean-Michel
  • Bliss, Fritz
  • Dott, Pascal Jean Claude
  • Hoffmann-Emery, Fabienne Roxane
  • Larsson, Ulf Göran
  • Puentener, Kurt

Abstract

The invention provides a novel process for manufacturing a compound of formula (I), or a salt thereof, The invention provides a novel process for manufacturing a compound of formula (I), or a salt thereof, The invention provides a novel process for manufacturing a compound of formula (I), or a salt thereof, wherein PG1, PG2 and PG3 are amino protective groups. The process according to the invention is particularly suitable for large-scale manufacturing under GMP conditions.

IPC Classes  ?

  • C07K 5/09 - Tripeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
  • C07D 209/20 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
  • C07D 209/26 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
  • C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides

29.

DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BRUTON'S TYROSINE KINASE

      
Application Number 18793023
Status Pending
Filing Date 2024-08-02
First Publication Date 2025-04-03
Owner Genentech, Inc. (USA)
Inventor
  • Mao, Chen
  • Kou, Dawen
  • Chiang, Po-Chang

Abstract

The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound(S)-2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino) -6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton's tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.

IPC Classes  ?

  • C07D 487/04 - Ortho-condensed systems
  • A61K 9/10 - DispersionsEmulsions
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/20 - Pills, lozenges or tablets
  • A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
  • C07C 309/04 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group

30.

METHODS FOR VIRAL INACTIVATION AND OTHER ADVENTITIOUS AGENTS

      
Application Number 18978296
Status Pending
Filing Date 2024-12-12
First Publication Date 2025-04-03
Owner Genentech, Inc. (USA)
Inventor
  • Shiratori, Masaru Ken
  • Kiss, Robert David
  • Prashad, Hardayal
  • Iverson, Raquel
  • Bourret, Justin
  • Kim, Michael
  • Charaniya, Salim

Abstract

The invention provides for methods of viral inactivation using high temperature short time (HTST) treatment and adjustment of various parameters such that generation of precipitate and depositions of precipitate are reduced and/or minimized.

IPC Classes  ?

  • C12N 1/36 - Adaptation or attenuation of cells
  • C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

31.

DUAL SPECIFIC ANTIBODIES

      
Application Number 18980433
Status Pending
Filing Date 2024-12-13
First Publication Date 2025-04-03
Owner Genentech, Inc. (USA)
Inventor
  • Fuh, Germaine
  • Lee, Chingwei V.
  • Koenig, Patrick

Abstract

The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.

IPC Classes  ?

  • C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07K 16/46 - Hybrid immunoglobulins

32.

COMPUTER IMPLEMENTED METHOD FOR PERFORMANCE VERIFICATION OF A THERMAL BLOCK CYCLER UNIT

      
Application Number 18903718
Status Pending
Filing Date 2024-10-01
First Publication Date 2025-04-03
Owner Roche Molecular Systems, Inc. (USA)
Inventor
  • Dobrzynski, Michal Karol
  • Federer, Paul Ivo
  • Vicente Leitao, Ivo Daniel
  • Vollenweider, Stefan

Abstract

A computer-implemented method for performance verification of a thermal block cycler unit for automated thermal treatment of at least one sample is described. The thermal block cycler unit includes at least one thermal block configured for receiving at least one sample vessel, and a plurality of hardware modules. The hardware modules include a plurality of heating and/or cooling elements and at least one temperature sensor. The method includes consecutively functional testing the hardware modules, and defining the order of tests by using a thermal energy of its preceding test and/or a status of the thermal block cycler unit of its preceding test, and balancing energy consumption between the steps to minimize a difference between an input temperature before consecutively testing the hardware modules and an output temperature after consecutively testing the hardware modules.

IPC Classes  ?

  • G16B 25/20 - Polymerase chain reaction [PCR]Primer or probe designProbe optimisation

33.

MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE

      
Application Number EP2024076704
Publication Number 2025/068132
Status In Force
Filing Date 2024-09-24
Publication Date 2025-04-03
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Kou, Buyu
  • Liu, Haixia
  • Shen, Hong
  • Wu, Yao
  • Zhang, Zhiwei
  • Zhu, Wei

Abstract

The application relates to compounds of formula (I) which act as antagonists of STING useful for the treatment of autoimmune diseases, inflammatory diseases, neurological disorders, metabolic diseases, cardiovascular diseases, ocular diseases, or selective types of cancer where overexpression or activation of STING is implicated.

IPC Classes  ?

  • C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
  • A61P 3/00 - Drugs for disorders of the metabolism
  • A61P 9/00 - Drugs for disorders of the cardiovascular system
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 27/02 - Ophthalmic agents
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
  • A61P 35/00 - Antineoplastic agents
  • A61P 37/00 - Drugs for immunological or allergic disorders
  • A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

34.

ANTIBODY THAT BINDS TO C3bBb

      
Application Number EP2024076826
Publication Number 2025/068207
Status In Force
Filing Date 2024-09-25
Publication Date 2025-04-03
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Bertoldo, Davide
  • Butzer, Joachim
  • Fenn, Sebastian
  • Fidler, Alexander
  • Jochner, Anton
  • Koertvely, Eloed
  • Mary, Jean-Luc
  • Priner, Sebastian

Abstract

The present invention relates to anti-C3bBb antibodies and methods of using the same.

IPC Classes  ?

  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C07K 16/14 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from fungi, algae or lichens
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

35.

PEPTIDE BIOMARKER

      
Application Number EP2024077048
Publication Number 2025/068363
Status In Force
Filing Date 2024-09-26
Publication Date 2025-04-03
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Terrigno, Marco
  • Vikesaa, Jonas
  • Wang, Congwei

Abstract

The present invention relates to a splice variant of an ICA1 protein that acts as a biomarker for a TDP-43 pathology. In particular, the present invention relates to methods for identifying a splice variant of ICA1 comprising a cryptic peptide sequence, and to related methods of identifying a TDP-43 pathology and/or reduced TDP-43 function in a subject.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

36.

END-TO-END INTEGRATED FEDERATED RESEARCH PLATFORM

      
Application Number EP2024077344
Publication Number 2025/068551
Status In Force
Filing Date 2024-09-27
Publication Date 2025-04-03
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • GENENTECH, INC. (USA)
  • HOFFMANN-LA ROCHE INC. (USA)
  • ROCHE MOLECULAR SYSTEMS, INC. (USA)
  • ROCHE DIAGNOSTICS GMBH (Germany)
Inventor
  • Boernert, Eric
  • Buijs, Frederik Nicolaas
  • Gysin, Shauna Jane
  • Kaczmarek, Lukasz Bernard
  • Kemisetti, Anil Prabhakar Kannappa
  • Sharma, Vishakha
  • Szubstarski, Bartłomiej
  • Tackenberg, Bjoern

Abstract

A federated analytics (FA)/federated learning (FL) system configured to implement a federated learning pipeline or a federated analytics pipeline comprises: a centralized FA/FL platform comprising a client environment interface module; and a plurality of local environments, each local environment comprising a respective local memory configured to store local raw data and/or local pre-processed data. The local environments are configured to obtain data from data sources, and to generate local statistical models which are aggregated at the centralized platform to generate a global statistical model, thereby fulfilling a client request.

IPC Classes  ?

  • G06N 20/00 - Machine learning
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

37.

OCULAR CANNULA GUIDE, APPLICATOR, AND MARKING INSTRUMENT

      
Application Number US2024048755
Publication Number 2025/072590
Status In Force
Filing Date 2024-09-27
Publication Date 2025-04-03
Owner GENENTECH, INC. (USA)
Inventor
  • Meyer, Thomas, E.
  • Hedgeland, Mark
  • Creel, Justin, A.
  • Miser, John, Dale
  • Meinz, Peter, James
  • Ahrens, Olivia
  • Schafer, Jerome, Joseph
  • Stewart, Kyle
  • Gernetzke, Thomas, Anthony

Abstract

An apparatus (200) includes a pair of rigid legs (210) extending parallel with each other along a plane. Each leg of the pair of legs has a sharp tip (215). The apparatus also includes head (210), including a top surface (222), a bottom surface (224), a pair of end surfaces (226), a pair of side surfaces (227), and a guide notch (230) extending upwardly from the bottom surface. The guide notch is configured to cooperate with a surface of a sclera of a patient's eye to define a guide opening that is oriented transversely relative to the plane associated with the legs and that is sized to receive a cannula having a generally flat profile. The head further includes a pair of receptacles (240) extending laterally inwardly from respective side surfaces of the pair of side surfaces. Each receptacle of the pair of receptacles is configured to engage a deployment instrument.

IPC Classes  ?

  • A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
  • A61F 9/013 - Methods or devices for eye surgery for compensation of ocular refraction
  • A61B 17/10 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for applying or removing wound clampsWound clamp magazines
  • A61B 17/064 - Surgical staples
  • A61B 17/34 - TrocarsPuncturing needles
  • A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors

38.

FORMS OF PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES, ITS FORMULATION AND ITS PROCESS OF MAKING

      
Application Number 18885056
Status Pending
Filing Date 2024-09-13
First Publication Date 2025-04-03
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Meier, Roland
  • Schwitter, Urs
  • De Paepe, Anne
  • Kuehl, Peter
  • Thun, Juergen
  • Stowasser, Frank

Abstract

The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one useful as pharmaceutically active compounds.

IPC Classes  ?

  • C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

39.

METHODS OF TREATING CANCER USING TIGIT INHIBITORS AND ANTI-CANCER AGENTS

      
Application Number 18978156
Status Pending
Filing Date 2024-12-12
First Publication Date 2025-04-03
Owner Genentech, Inc. (USA)
Inventor Grogan, Jane L.

Abstract

The present disclosure provides methods comprising administering to the individual an effective amount of an agent that decreases or inhibits TIGIT expression and/or activity and an anti-cancer agent and/or an anti-cancer therapy. Further provided are kits comprising an anti-cancer agent, an agent that decreases or inhibits TIGIT expression and/or activity, or both, as well as instructions for use thereof.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61K 38/19 - CytokinesLymphokinesInterferons
  • A61K 38/20 - Interleukins
  • A61K 38/21 - Interferons
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • A61P 35/00 - Antineoplastic agents
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

40.

MICROSCOPE SLIDE IMAGE-BASED MACHINE LEARNING IMAGE ANALYSIS FOR INFLAMMATORY BOWEL DISEASE

      
Application Number 18981081
Status Pending
Filing Date 2024-12-13
First Publication Date 2025-04-03
Owner Genentech, Inc. (USA)
Inventor Scherl, Alexis

Abstract

A method includes determining, within an image of a biological sample from an intestine of a patient, a plurality of image patches depicting a portion of the biological sample. A plurality of bowel disease indication groups corresponding to a subset of the plurality of image patches may be determined based at least on the plurality of image patches. A group-level histological score for each bowel disease indication group of the plurality of bowel disease indication groups may be generated based at least on the subset of the plurality of image patches contained in each respective group. An aggregated histological score indicative of a disease burden in the intestine of the patient may be generated based on the generated group-level histological score for each bowel disease indication group. Related systems and computer program products are also provided.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
  • G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

41.

DETECTING LONGITUDINAL PROGRESSION OF ALZHEIMER'S DISEASE (AD) BASED ON SPEECH ANALYSES

      
Application Number 18981116
Status Pending
Filing Date 2024-12-13
First Publication Date 2025-04-03
Owner Genentech, Inc. (USA)
Inventor
  • Robin, Jessica
  • Kahn, Laurence
  • Teng, Edmond Huatung

Abstract

A method implemented by one or more computer device includes detecting longitudinal progression of Alzheimer's disease (AD) in a patient. The method includes receiving speech data including a patient's description of one or more previous or current experiences of the patient, in which the speech data was captured at a plurality of moments during a period of time. The method further includes analyzing the speech data to quantify a plurality of speech variables, in which the plurality of speech variables includes a word-length variable and a use-of-particles variable. The method includes determining a composite score based on a standardization and a substantive weighting assigned to each of the quantified plurality of speech variables. The method thus includes detecting, based on the composite score, a predicted longitudinal change in the quantified speech variables, and further estimating, based on the predicted longitudinal change, a progression of AD for the patient.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires

42.

THERAPEUTIC COMPOUNDS AND METHODS

      
Application Number 18657963
Status Pending
Filing Date 2024-05-08
First Publication Date 2025-04-03
Owner GENENTECH, INC. (USA)
Inventor
  • Green, Samantha Alyson
  • Grandner, Jessica Marie
  • Staben, Steven Thomas
  • Amara, Neri
  • Dixit, Vishva M.
  • Villemure, Elisia

Abstract

The invention provides a compound of formula (I): The invention provides a compound of formula (I): The invention provides a compound of formula (I): or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 have any of the values described in the specification, as well as compositions comprising a compound of formula (I) or a prodrug thereof, or a pharmaceutically acceptable salt thereof. The compounds are agonists of glycolytic enzyme phosphofructokinase-1 liver type and are useful for treating diseases associated with the activity of glycolytic enzyme phosphofructokinase-1 liver type, such as cancer, diabetes, sepsis, and septic shock.

IPC Classes  ?

  • C07D 498/04 - Ortho-condensed systems
  • A61K 9/08 - Solutions
  • A61K 9/12 - AerosolsFoams
  • A61K 9/20 - Pills, lozenges or tablets
  • A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
  • A61K 47/02 - Inorganic compounds
  • A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
  • A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
  • C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
  • C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

43.

METHODS FOR PRODUCING MOLECULES

      
Application Number EP2024076567
Publication Number 2025/068075
Status In Force
Filing Date 2024-09-23
Publication Date 2025-04-03
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Frensing, Timo
  • Huetten, Jasmin
  • Popp, Oliver

Abstract

Methods are disclosed for producing a molecule comprising a polypeptide complex formed by interaction between a first polypeptide comprising a CH3 region comprising a knob modification and a second polypeptide comprising a CH3 region comprising a hole modification.

IPC Classes  ?

  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

44.

METHOD FOR DECELERATING THE DECAY-DISSOCIATION OF C3BBB COMPLEX

      
Application Number EP2024076827
Publication Number 2025/068208
Status In Force
Filing Date 2024-09-25
Publication Date 2025-04-03
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Fenn, Sebastian
  • Fidler, Alexander
  • Jochner, Anton
  • Koertvely, Eloed
  • Mary, Jean-Luc

Abstract

The present invention relates to a method for stabilizing the C3bBb complex, a rapidly decaying component of the alternative pathway of the complement system, and stabilized C3bBb complexes and uses thereof.

IPC Classes  ?

  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

45.

NEW HETEROCYCLIC COMPOUNDS

      
Application Number EP2024077022
Publication Number 2025/068347
Status In Force
Filing Date 2024-09-26
Publication Date 2025-04-03
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Benz, Joerg Matthias
  • Giroud, Maude
  • Grether, Uwe Michael
  • Kuhn, Bernd Willi
  • O'Hara, Fionn Susannah
  • Rombach, Didier

Abstract

The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, U, V, X, Y, L1, R1, and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

IPC Classes  ?

  • C07D 495/10 - Spiro-condensed systems
  • C07D 513/10 - Spiro-condensed systems
  • C07D 515/10 - Spiro-condensed systems
  • A61P 25/22 - Anxiolytics
  • A61P 25/24 - Antidepressants
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
  • A61P 35/00 - Antineoplastic agents

46.

TUMOR DYNAMICS MODELING USING OMICS-BASED DATA

      
Application Number US2024049345
Publication Number 2025/072976
Status In Force
Filing Date 2024-09-30
Publication Date 2025-04-03
Owner GENENTECH, INC. (USA)
Inventor
  • Lu, James
  • Bazgir, Omid

Abstract

Systems and methods of prediction of future tumor data. A tumor embedding at a neural ordinary differential equations (ODE) system is received. The tumor embedding is generated using a tumor encoder and observed tumor data that is observed over a selected period of time after a reference point in time. A graph embedding at the neural ODE is received. The graph embedding fuses drug information, disease information, and gene relationship information. The graph embedding is generated using a heterogenous graph encoder that fuses together at least two or more embeddings generated using bipartite graph convolution attention networks. A predicted tumor size at a future point in time is generated using the tumor embedding, the graph embedding, and the neural ODE system. A candidate tumor treatment is administered to a subject in response to the predicted tumor size being less than a selected threshold.

IPC Classes  ?

  • G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
  • G06N 3/045 - Combinations of networks
  • G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

47.

COBAS LUMIRA

      
Serial Number 99117674
Status Pending
Filing Date 2025-04-02
Owner Roche Diagnostics Operations, Inc. ()
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 10 - Medical apparatus and instruments

Goods & Services

Chemical, biological and biochemical preparations for the analysis of biological samples for medical purposes; medical diagnostic assays and reagents for the analysis of biological samples for clinical or medical purposes; diagnostic reagents and preparations for medical purposes; in vitro diagnostic agents for the analysis of biological samples for medical purposes; all of the foregoing excluding active pharmaceutical ingredients, isotopes and radioisotopes Analyzers for the analysis of biological samples for medical diagnostic purposes; in vitro diagnostic devices in the nature of biosensors for the detection and analysis of medically significant analytes in biological samples for medical purposes

48.

COMBINATION THERAPY OF ANTI-TYRP1/ANTI-CD3 BISPECIFIC ANTIBODIES AND TYRP1-SPECIFIC ANTIBODIES

      
Application Number 18668810
Status Pending
Filing Date 2024-05-20
First Publication Date 2025-03-27
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Klein, Christian
  • Nicolini, Valeria G.
  • Umaña, Pablo

Abstract

The present invention relates to the combination therapy of a bispecific antibody which binds human TYRP1 and CD3 and a second TYRP1-specific antibody.

IPC Classes  ?

  • C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61P 35/00 - Antineoplastic agents
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

49.

ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER

      
Application Number 18739171
Status Pending
Filing Date 2024-06-10
First Publication Date 2025-03-27
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Amann, Maria
  • Bruenker, Peter
  • Claus, Christina
  • Ferrara Koller, Claudia
  • Grau-Richards, Sandra
  • Klein, Christian
  • Levitski, Viktor
  • Moessner, Ekkehard
  • Regula, Joerg
  • Umana, Pablo

Abstract

The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

IPC Classes  ?

  • C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

50.

HETEROCYCLIC COMPOUNDS

      
Application Number 18832840
Status Pending
Filing Date 2023-01-25
First Publication Date 2025-03-27
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Amoussa, Machoud
  • Benz, Joerg
  • Blaising, Julie Elisabeth Francoise
  • Denizot, Jason Jacques
  • Friston, Kallie
  • Ganzoni, Rudolf Liun Zaccaria
  • Giroud, Maude
  • Grether, Uwe
  • Hornsperger, Benoit
  • Kaufmann, Isabelle
  • Kuhn, Bernd
  • Leake, Camiel John
  • Margarini, Jacopo
  • Martin, Rainer Eugen
  • O'Hara, Fionn Susannah
  • Puellmann, Bernd
  • Ritter, Martin
  • Rombach, Didier
  • Runtz-Schmitt, Valerie
  • Schmid, Philipp Claudio
  • Wittwer, Matthias Beat

Abstract

The invention provides new heterocyclic compounds having the general formula (I) wherein A and R1 to R4 are as described heroin, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds. The invention provides new heterocyclic compounds having the general formula (I) wherein A and R1 to R4 are as described heroin, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

IPC Classes  ?

  • A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
  • A61K 31/4196 - 1,2,4-Triazoles
  • A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
  • A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
  • A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
  • A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • C07D 487/10 - Spiro-condensed systems

51.

METHOD OF VERIFYING A PROGRAM CODE OF A SYNTHESIS COMPUTER PROGRAM

      
Application Number 18974519
Status Pending
Filing Date 2024-12-09
First Publication Date 2025-03-27
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Komisarski, Marek Stanislaw
  • Mueller, Pascal
  • Olbrich, Martin
  • Popov, Maxim
  • Romano, Johanna
  • Schuster, Andreas

Abstract

A method of verifying a program code of a synthesis computer program is disclosed. The synthesis computer program is configured for computer-controlling an automatic synthesizer (114) to automatically synthesize at least one oligonucleotide, the synthesis computer program having a plurality of program cycles for computer-controlling the automatic synthesizer (114) to sequentially synthesize the oligonucleotide by using at least one sequence of synthesis cycles. The method comprises: i. applying an automatic parsing procedure to the program code of the synthesis computer program, the automatic parsing procedure comprising automatically searching for parameter values of parameters of at least one predetermined list of parameters of interest in the program cycles of the synthesis computer program; and ii. automatically assembling a matrix of parameters comprising, for the program cycles of the synthesis computer program, the parameters of interest and the corresponding parameter values of the parameters of interest. A method of verifying a program code of a synthesis computer program is disclosed. The synthesis computer program is configured for computer-controlling an automatic synthesizer (114) to automatically synthesize at least one oligonucleotide, the synthesis computer program having a plurality of program cycles for computer-controlling the automatic synthesizer (114) to sequentially synthesize the oligonucleotide by using at least one sequence of synthesis cycles. The method comprises: i. applying an automatic parsing procedure to the program code of the synthesis computer program, the automatic parsing procedure comprising automatically searching for parameter values of parameters of at least one predetermined list of parameters of interest in the program cycles of the synthesis computer program; and ii. automatically assembling a matrix of parameters comprising, for the program cycles of the synthesis computer program, the parameters of interest and the corresponding parameter values of the parameters of interest. Further disclosed is a computer program and a computer-readable storage medium for performing the method of verifying a program code of a synthesis computer program, a system (110) for verifying a program code of a synthesis computer program and a method of synthesizing at least one oligonucleotide.

IPC Classes  ?

52.

METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE

      
Application Number 18820893
Status Pending
Filing Date 2024-08-30
First Publication Date 2025-03-27
Owner Genentech, Inc. (USA)
Inventor
  • Pan, Lin
  • Rhee, Horace H.
  • Tang, Fei

Abstract

This disclosure relates to methods, uses, and compositions (e.g., articles of manufacture and kits) comprising an anti-OSMRβ antibody, such as vixarelimab, for the treatment of inflammatory gastrointestinal diseases associated with the oncostatin M (OSM) pathway (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC (e.g., moderate to severe UC)) and Crohn's disease (CD)).

IPC Classes  ?

  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

53.

DETERMINING LIKELIHOOD OF KIDNEY FAILURE

      
Application Number 18728195
Status Pending
Filing Date 2023-01-24
First Publication Date 2025-03-27
Owner Roche Diagnostics Operations, Inc. (USA)
Inventor
  • Danzer, Carsten
  • Emons, Martin Josef
  • Klammer, Martin
  • Sillitoe, Nicolas Seungoon
  • Triunfo, Riccardo

Abstract

A computer-implemented method is provided, which determines at a prediction time tp, a likelihood of kidney failure of a patient within an amount of time Δt. The method comprises receiving input data, the input data comprising a recent creatinine level cR or recent eGFR eGFRR, and one or more of the following: (a) an initial creatinine level c0 and either: a time t0 at which the initial creatinine level c0 was measured, or a time interval ΔT0=tp−t0; (b) an initial estimated glomerular filtration rate (eGFR) eGFR0 and either: a time t0 at which the initial eGFR was determined, or a time interval ΔT0=tp−t0; (c) for a plurality of past creatinine level measurements ci measured at a respective times ti, a statistical parameter derived from a linear regression of the plurality of past creatinine level measurements; and (d) for a plurality of past eGFR values eGFRi determined at respective times ti, a statistical parameter derived from a linear regression of the plurality of past eGFR values; and applying a machine-learning model to the input data to generate an output indicating the likelihood of kidney failure within the given amount of time Δt. Corresponding training methods and systems are also provided.

IPC Classes  ?

  • A61B 5/20 - Measuring urological functions
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

54.

MODIFIED MAMMALIAN CELLS

      
Application Number 18823189
Status Pending
Filing Date 2024-09-03
First Publication Date 2025-03-27
Owner Genentech, Inc. (USA)
Inventor
  • Laird, Michael Wilson
  • Misaghi, Shahram
  • Shen, Amy
  • Tomlinson, Anthony
  • Yuk, Inn Huam

Abstract

The present disclosure relates to methods, cells, and compositions for producing a product of interest, e.g., a recombinant protein. In particular, the present disclosure provides improved mammalian cells expressing the product of interest, where the cells (e.g., Chinese Hamster Ovary (CHO) cells) have reduced or eliminated activity, e.g., expression, of certain host cell proteins, e.g., enzymes including, but not limited to, certain lipases, esterases, and/or hydrolases.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

55.

ESTIMATION OF QUANTITATIVE SYSTEMS PHARMACOLOGY (QSP) TREATMENT EFFECT PARAMETERS USING DEEP LEARNING

      
Application Number 18961292
Status Pending
Filing Date 2024-11-26
First Publication Date 2025-03-27
Owner Genentech, Inc. (USA)
Inventor Lu, James

Abstract

A method and system for evaluating a treatment using one or more model parameters associated with a quantitative systems pharmacology (QSP) system. Input data corresponding to a treatment is received. The input data is sent to a machine learning system that has been trained, the machine learning system representing at least a portion of the QSP model. The machine learning system is used to generate a set of values for a set of treatment effect parameters associated with the QSP model. A final output is generated based on an evaluation of the treatment on a subject using the set of values for the set of treatment effect parameters.

IPC Classes  ?

  • G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
  • G06N 3/0455 - Auto-encoder networksEncoder-decoder networks
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

56.

THERMAL CONTROL DEVICE FOR TEMPERATURE CYCLING, METHOD FOR CONTROLLING TEMPERATURE CYCLING USING A THERMAL CONTROL DEVICE, AND SYSTEM FOR CONTROLLING TEMPERATURE OF A SAMPLE USING A THERMAL CONTROL DEVICE

      
Application Number EP2024076377
Publication Number 2025/061910
Status In Force
Filing Date 2024-09-20
Publication Date 2025-03-27
Owner
  • ROCHE DIAGNOSTICS GMBH (Germany)
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • ROCHE DIAGNOSTICS OPERATIONS, INC. (USA)
Inventor
  • Fischer, Simon
  • Sangermano, Marco
  • Wiget, Pascal

Abstract

In one embodiment, a thermal control device (110) adapted for temperature cycling is provided. The thermal control device (110) comprises a thermally conductive heat spreader layer (118) comprising a first side surface and a second side surface. A heater circuit (120) is disposed adjacent to and in thermal contact with at least one of the first side surface and the second side surface of the thermally conductive heat spreader layer (118). At least one thermal interface material layer (114) is disposed adjacent to and in thermal contact with one of the first side surface and the second side surface of the thermally conductive heat spreader layer (118). A cooling block (116) is disposed adjacent to and in thermal contact with the thermal interface material layer (114). The cooling block (116) is adapted to conduct heat energy away from the thermally conductive heat spreader layer (118). A controller is coupled to and adapted to control the heater circuit (120). In another embodiment, a diagnostic test device is provided.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatusHeat insulating devices

57.

CIRCULATING BMP10 (BONE MORPHOGENIC PROTEIN 10) IN THE ASSESSMENT OF CONGESTION AND PULMONARY HYPERTENSION

      
Application Number EP2024076081
Publication Number 2025/061752
Status In Force
Filing Date 2024-09-18
Publication Date 2025-03-27
Owner
  • ROCHE DIAGNOSTICS GMBH (Germany)
  • ROCHE DIAGNOSTICS INTERNATIONAL AG (Switzerland)
Inventor
  • Ceelen, Daan
  • De Boer, Rudolf
  • Eberl, Magdalena Anna
  • Gillet, Ludovic
  • Hennings, Elisa Juliane
  • Kastner, Peter
  • Masson, Serge
  • Osswald, Stefan
  • Palme, Stefan
  • Pfister, Otmar
  • Suthahar, Navin
  • Voors, Adriaan
  • Wienhues-Thelen, Ursula-Henrike
  • Ziegler, Andre

Abstract

The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing congestion in a subject comprising the steps of determining in a sample of the subject the amount of a BMP 10-type peptide (Bone Morphogenic Protein 10-type peptide) and comparing the amount of the BMP 10-type peptide to a reference for the BMP 10-type peptide, whereby congestion is to be assessed. The present invention also contemplates a method of differentiating between precapillary pulmonary hypertension and postcapillary pulmonary hypertension. Further, the invention concerns computer-implemented methods of the aforementioned methods as well as devices and kits for carrying out said methods. Yet, the invention in general relates to the use of a BMP 10-type peptide or a detection agent therefor in a sample of a subject for assessing congestion or the use of a BMP 10-type peptide or a detection agent therefor in a sample of a subject for differentiating between precapillary pulmonary hypertension and postcapillary pulmonary hypertension.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

58.

GYSERDIS

      
Application Number 019162369
Status Pending
Filing Date 2025-03-25
Owner F. Hoffmann-La Roche AG (Switzerland)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations.

59.

GYSERDIS

      
Serial Number 99102713
Status Pending
Filing Date 2025-03-25
Owner Genentech, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations for use in oncology

60.

QUANTIFICATION OF LOW AMOUNTS OF ANTIBODY SIDE-PRODUCTS

      
Application Number 18672669
Status Pending
Filing Date 2024-05-23
First Publication Date 2025-03-20
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Lariviere, Laurent
  • Schlothauer, Tilman
  • Spick, Christian
  • Zwick, Adrian

Abstract

The current invention is directed to a method for determining homodimeric avid-binding side-products of a bispecific antibody in a sample comprising the correctly assemble heterodimeric affine-binding bispecific antibody and the mis-assembled homodimeric avid-binding side-product of the bispecific antibody using surface plasmon resonance, wherein the correctly assembled heterodimeric affine-binding bispecific antibody comprises one or more binding site for a first antigen and one or more binding sites for a second antigen, wherein the mis-assembled homodimeric avid-binding side-product of the bispecific antibody comprises two or more binding sites to the first antigen but at least more than the correctly assembled bispecific antibody, wherein the correctly assembled bispecific antibody is a heterodimer and the mis-assembled bispecific antibody is a homodimer, wherein the presence of the homodimeric avid-binding side-product is determined if residual binding, i.e. an increased SPR signal, can be determined in the dissolution phase of the SPR analysis.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
  • G01N 21/59 - Transmissivity
  • G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

61.

ANTIBODIES BINDING TO CD3

      
Application Number 18784587
Status Pending
Filing Date 2024-07-25
First Publication Date 2025-03-20
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Bujotzek, Alexander Christian
  • Gassner, Christian Robert
  • Klein, Christian
  • Leclair, Stéphane Gérard Alain
  • Maersch, Stephan
  • Moessner, Ekkehard
  • Waldhauer, Inja

Abstract

The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

IPC Classes  ?

  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes

62.

FOLR1 PROTEASE-ACTIVATABLE T CELL BISPECIFIC ANTIBODIES

      
Application Number 18901300
Status Pending
Filing Date 2024-09-30
First Publication Date 2025-03-20
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Bruenker, Peter
  • Geiger, Martina
  • Klein, Christian
  • Umaña, Pablo

Abstract

The present invention generally relates to improved Protease-activatable antigen-binding molecules that comprise an anti-idiotype-binding moiety which reversibly masks a CD3 antigen binding moiety of the molecule. Furthermore, the invention relates to novel Protease-cleavable peptide linkers and their used in such Protease-activatable antigen-binding molecules. In addition, the present invention relates to polynucleotides encoding such Protease-activated T cell binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the Protease-activated T cell binding molecules of the invention, and to methods of using the same, e.g., in the treatment of disease.

IPC Classes  ?

  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61P 35/00 - Antineoplastic agents
  • C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)

63.

Subcutaneous anti-HER2 Antibody Formulations and Uses Thereof

      
Application Number 18635280
Status Pending
Filing Date 2024-04-15
First Publication Date 2025-03-20
Owner Genentech, Inc. (USA)
Inventor
  • Adler, Michael
  • Grauschopf, Ulla
  • Mahler, Hanns-Christian
  • Stauch, Oliver Boris

Abstract

The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/08 - Solutions
  • A61K 9/19 - Particulate form, e.g. powders lyophilised
  • A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
  • A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
  • A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
  • C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes

64.

MACHINE LEARNING MODELS FOR CELL LINE SELECTION

      
Application Number EP2024075160
Publication Number 2025/056482
Status In Force
Filing Date 2024-09-10
Publication Date 2025-03-20
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Chung, Shan-Hua
  • Grosskopf, Daniel Tobias
  • Papadaki, Styliani
  • Popp, Oliver Helmut
  • Quaiser, Tom Kamran
  • Stoeckl, Laura Susanne
  • Tournaviti, Styliani

Abstract

Methods for facilitating selection of cell lines for production of recombinant proteins are disclosed. In particular, disclosed is the use of machine learning models trained on multiomics data to predict one or more values indicative of the titre and/or quality of a recombinant protein expressed by different cell lines, enabling ranking the cell lines based on the predicted values and selecting those predicted to produce the recombinant protein with higher titre and/or higher quality.

IPC Classes  ?

  • G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • G16B 40/20 - Supervised data analysis

65.

ANTIBODY FORMULATION

      
Application Number EP2024075456
Publication Number 2025/056655
Status In Force
Filing Date 2024-09-12
Publication Date 2025-03-20
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Allmendinger, Andrea
  • Fischer, Stefan

Abstract

This invention relates to a pharmaceutical formulation of an alpha synuclein antibody.

IPC Classes  ?

  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

66.

CLASSIFICATION METHOD FOR CLASSIFYING SYSTEMIC INFLAMMATORY STATES

      
Application Number EP2024075599
Publication Number 2025/056737
Status In Force
Filing Date 2024-09-13
Publication Date 2025-03-20
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • ROCHE DIAGNOSTICS GMBH (Germany)
  • ROCHE DIAGNOSTICS OPERATIONS, INC. (USA)
Inventor
  • Bundschus, Markus
  • Schoedl, Thomas
  • Wohlfart, Christian

Abstract

A computer-implemented training method (110) of training at least one trainable model is disclosed for classifying a patient's health condition into a systemic inflammatory state (168, 170, 172) selected from a predetermined group of at least three systemic inflammatory states (168, 170, 172). The method comprises: a. providing the trainable model; b. retrieving labeled training patient data, the training patient data comprising gene expression data of patients having known systemic inflammatory states (168, 170, 172); and c. training the trainable model on the labeled training patient data. Further disclosed is a computer-implemented classification method (112) of classifying a patient's health condition into a systemic inflammatory state (168, 170, 172) selected from a predetermined group of at least three systemic inflammatory states (168, 170, 172) and systems, computer programs and computer-readable storage media for performing the methods.

IPC Classes  ?

  • G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
  • G16B 40/20 - Supervised data analysis
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

67.

METHOD FOR ASSESSING SYSTEMIC INFLAMMATION

      
Application Number EP2024075667
Publication Number 2025/056769
Status In Force
Filing Date 2024-09-13
Publication Date 2025-03-20
Owner
  • ROCHE DIAGNOSTICS GMBH (Germany)
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • ROCHE DIAGNOSTICS OPERATIONS, INC. (USA)
Inventor
  • Bundschus, Markus
  • Schoedl, Thomas
  • Wohlfart, Christian

Abstract

The present invention relates to the field of diagnostics. In particular, it relates to a method for assessing systemic inflammation in a subject exhibiting symptoms thereof comprising a) determining in a sample of said subject the amounts of biomarkers from a group of biomarkers selected from i) a first group of biomarkers comprising: POMK, NEK6, KCNA5, LARGE2, ZNF425, NACA2, CFAP57, SPINT1, ZNF492, and S100A6, ii) a second group of biomarkers comprising: NEK6, SRPK3, TNFSF8, S100A6, NMUR1, DHFR, HIST1H4D, ZDHHC4, TRAF3, and SGMSlor iii) a third group of biomarkers comprising: C9orfl35, ZNF425, ACOT4, SPDYA, DAPP1, LY86, ZPBP2, RPL3L, UPK1B, and APBB3, b) comparing said determined amounts of biomarkers from said group of biomarkers to a reference, and c) assessing systemic inflammation in the subject. Further, the present invention, in general, relates to the use of the amounts of said biomarkers in a sample of a subject exhibiting symptoms of systemic inflammation for assessing systemic inflammation. Moreover, contemplated are a device and a kit for assessing systemic inflammation.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

68.

DAYFEBNI

      
Application Number 1845677
Status Registered
Filing Date 2025-01-23
Registration Date 2025-01-23
Owner F. Hoffmann-La Roche AG (Switzerland)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations.

69.

BIOMARKERS AND METHODS OF TREATING PD-1 AND PD-L1 RELATED CONDITIONS

      
Application Number 18963935
Status Pending
Filing Date 2024-11-29
First Publication Date 2025-03-20
Owner Genentech, Inc. (USA)
Inventor
  • Kowanetz, Marcin
  • Chen, Daniel Shin-Yu
  • Koeppen, Hartmut

Abstract

Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

IPC Classes  ?

  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • G06Q 30/0241 - Advertisements
  • G06Q 30/0251 - Targeted advertisements

70.

GENE BIOMARKERS FOR MAMMALIAN CELL POOL PRODUCTIVITY PREDICTION AND SCREENING

      
Application Number EP2024075149
Publication Number 2025/056477
Status In Force
Filing Date 2024-09-10
Publication Date 2025-03-20
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Chung, Shan-Hua
  • Grosskopf, Daniel Tobias
  • Papadaki, Styliani
  • Popp, Oliver Helmut
  • Quaiser, Tom Kamran
  • Tournaviti, Styliani

Abstract

Methods for selecting cell pools for production of recombinant proteins are disclosed. In particular, disclosed is the use of one or more genes whose expression level can be used as a biomarker to predict which cell pool, among a plurality of cell pools, produces a recombinant protein with higher titre and/or higher quality.

IPC Classes  ?

  • C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

71.

PROCESS FOR THE PREPARATION OF 7-(4,7-DIAZASPIRO[2.5]OCTAN-7-YL)-2-(2,8-DIMETHYLIMIDAZO[1,2-B]PYRIDAZIN-6-YL)PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES

      
Application Number 18797280
Status Pending
Filing Date 2024-08-07
First Publication Date 2025-03-13
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Adam, Jean-Michel
  • Fantasia, Serena Maria
  • Fishlock, Daniel Vincent
  • Hoffmann-Emery, Fabienne
  • Moine, Gerard
  • Pfleger, Christophe
  • Moessner, Christian

Abstract

The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.

IPC Classes  ?

  • C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
  • B01J 23/44 - Palladium
  • B01J 23/755 - Nickel

72.

LOW CONCENTRATION SINGLE PASS TANGENTIAL FLOW FILTRATION TO DE-BOTTLENECK CONNECTED AND/OR HIGH TITER FED BATCH PROCESSES

      
Application Number 18826764
Status Pending
Filing Date 2024-09-06
First Publication Date 2025-03-13
Owner Genentech, Inc. (USA)
Inventor
  • Lien, Molly Carpenter
  • Lazzareschi, John Robert
  • Bill, Jr., Jerome Joseph

Abstract

Exemplary systems and methods are provided for receiving a feed flow at a feed flow inlet of a single pass tangential flow filtration unit, wherein the single pass tangential flow filtration unit includes one or more membranes or membrane devices in a one-or two-stage configuration, and wherein a pressure drop across the one or more membranes or membrane devices is less than or equal to 30 psi. The systems and methods are configured to separate, using the one or more membranes or membrane devices in a one-or two-stage configuration, the feed stream into a permeate stream and a retentate stream and output the permeate stream through one or more permeate outlets and the retentate stream through one or more retentate outlets.

IPC Classes  ?

73.

PERTUZUMAB VARIANTS AND EVALUATION THEREOF

      
Application Number 18914687
Status Pending
Filing Date 2024-10-14
First Publication Date 2025-03-13
Owner Genentech, Inc. (USA)
Inventor
  • Gennaro, Lynn A.
  • Kao, Yung-Hsiang
  • Zhang, Yonghua

Abstract

The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.

IPC Classes  ?

  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

74.

METHODS OF TREATING CANCERS USING PD-1 AXIS BINDING ANTAGONISTS AND TAXANES

      
Application Number 18956269
Status Pending
Filing Date 2024-11-22
First Publication Date 2025-03-13
Owner Genentech, Inc. (USA)
Inventor
  • Kim, Jeong
  • Cheung, Jeanne

Abstract

The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.

IPC Classes  ?

  • C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
  • A61K 31/282 - Platinum compounds
  • A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

75.

LOW CONCENTRATION SINGLE PASS TANGENTIAL FLOW FILTRATION TO DE-BOTTLENECK CONNECTED AND/OR HIGH TITER FED BATCH PROCESSES

      
Application Number US2024045539
Publication Number 2025/054421
Status In Force
Filing Date 2024-09-06
Publication Date 2025-03-13
Owner GENENTECH, INC. (USA)
Inventor
  • Lien, Molly Carpenter
  • Lazzareschi, John Robert
  • Bill, Jr., Jerome Joseph

Abstract

Exemplary systems and methods are provided for receiving a feed flow at a feed flow inlet of a single pass tangential flow filtration unit, wherein the single pass tangential flow filtration unit includes one or more membranes or membrane devices in a one- or two-stage configuration, and wherein a pressure drop across the one or more membranes or membrane devices is less than or equal to 3Opsi. The systems and methods are configured to separate, using the one or more membranes or membrane devices in a one- or two-stage configuration, the feed stream into a permeate stream and a retentate stream and output the permeate stream through one or more permeate outlets and the retentate stream through one or more retentate outlets.

IPC Classes  ?

76.

PROCESS FOR PREPARING BTK INHIBITORS

      
Application Number 18797316
Status Pending
Filing Date 2024-08-07
First Publication Date 2025-03-13
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Bachmann, Stephan
  • Chytil, Lukas
  • Fantasia, Serena Maria
  • Fettes, Alec
  • Hoffmann, Ursula

Abstract

Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.

IPC Classes  ?

  • C07D 487/04 - Ortho-condensed systems
  • B01J 21/18 - Carbon
  • B01J 23/648 - Vanadium, niobium or tantalum
  • B01J 31/22 - Organic complexes
  • B01J 31/24 - Phosphines
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

77.

LIVER CIRRHOSIS DETECTION IN DIGITAL IMAGES

      
Application Number 18798454
Status Pending
Filing Date 2024-08-08
First Publication Date 2025-03-13
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Adamski, Szymon Grzegorz
  • Gutierrez Becker, Benjamin
  • Kotowski, Krzysztof
  • Krason, Agata
  • Kucharski, Damian Marek
  • Machura, Bartosz Jakub
  • Nalepa, Jakub Robert
  • Tessier, Jean

Abstract

The present invention relates to systems and methods to detect liver cirrhosis in digital images. Various embodiments of the present invention relate to systems and methods to detect liver cirrhosis in computed tomography (CT) scans and, more specifically but not limited, to systems and methods to detect liver cirrhosis via a model trained on highly-interpretable features.

IPC Classes  ?

78.

MACHINE LEARNING MODELS FOR CELL LINE SELECTION

      
Application Number 18830789
Status Pending
Filing Date 2024-09-11
First Publication Date 2025-03-13
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Chung, Shan-Hua
  • Grosskopf, Daniel Tobias
  • Papadaki, Styliani
  • Popp, Oliver Helmut
  • Quaiser, Tom Kamran
  • Stoeckl, Laura Susanne
  • Tournaviti, Styliani

Abstract

Methods for facilitating selection of cell lines for production of recombinant proteins are disclosed. In particular, disclosed is the use of machine learning models trained on multiomics data to predict one or more values indicative of the titre and/or quality of a recombinant protein expressed by different cell lines, enabling ranking the cell lines based on the predicted values and selecting those predicted to produce the recombinant protein with higher titre and/or higher quality.

IPC Classes  ?

  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
  • G16B 40/20 - Supervised data analysis

79.

CHIMERIC RECEPTORS

      
Application Number 18894979
Status Pending
Filing Date 2024-09-24
First Publication Date 2025-03-13
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Klein, Christian
  • Lang, Simone
  • Moessner, Ekkehard
  • Venetz, Dario

Abstract

The present invention generally relates to chimeric receptors comprising an extracellular domain comprising a mutated Fc domain. The invention also relates to transduced immune cells expressing the chimeric receptors of the invention and/or nucleic acid molecules encoding the chimeric receptors of the present invention. Further provided are kits comprising such cells and/or nucleic acid molecules encoding the chimeric receptors, and antibodies capable of binding to the chimeric receptors.

IPC Classes  ?

  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • C07K 14/725 - T-cell receptors
  • C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)

80.

HIGH VISCOSITY ULTRAFILTRATION/DIAFILTRATION AND SINGLE-PASS TANGENTIAL FLOW FILTRATION PROCESSES

      
Application Number 18826814
Status Pending
Filing Date 2024-09-06
First Publication Date 2025-03-13
Owner Genentech, Inc. (USA)
Inventor
  • Sackett, Benjamin Mark
  • Keba, James J.

Abstract

The present disclosure provides high viscosity ultrafiltration/diafiltration (UF/DF) and single-pass tangential flow filtration (SPTFF) processes used in the purification of polypeptides. A method for purifying a polypeptide from a polypeptide preparation may include the following steps in order: a) subjecting the polypeptide preparation to one or more purification processes and recovering a first resulting pool having a viscosity of about 5-40 cP; and b) subjecting the pool recovered from step a) to a SPTFF operation comprising use of membranes in either or both a serial membrane and/or a parallel membrane configuration and recovering a second resulting pool having an operating viscosity of about 41-400 cP, wherein, i) the operating temperature is about 15-55° C., and ii) the feed flux is about 5-50 L/m2/hr (LMH).

IPC Classes  ?

  • C07K 1/34 - ExtractionSeparationPurification by filtration, ultrafiltration or reverse osmosis
  • B01D 61/14 - UltrafiltrationMicrofiltration
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties

81.

IDENTIFICATION OF BINDING SITES IN A PROTEIN STRUCTURE

      
Application Number 18960282
Status Pending
Filing Date 2024-11-26
First Publication Date 2025-03-13
Owner Genentech, Inc. (USA)
Inventor Walters, Benjamin Thomas

Abstract

In one aspect, a method for identifying residues in a particular conformation of a protein molecule capable of forming a stable binding between a compound and the protein molecule is provided. The method can include identifying, for inclusion in a perturbation set, one or more residues from the conformation of the protein molecule that exhibit a protection factor satisfying one or more thresholds. One or more residues may be excluded from the perturbation set based at least on a spatial arrangement and/or an orientation of the one or more residues. One or more rounds of molecular dynamics simulations whose result is indicative of an interaction between the compound and the residues in the perturbation set may be performed. The residues in the perturbation set may be identified as forming a stable binding between the compound and the protein molecule based at least on the result of the molecular dynamics simulation

IPC Classes  ?

  • G16B 15/30 - Drug targeting using structural dataDocking or binding prediction

82.

TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER

      
Application Number 18913161
Status Pending
Filing Date 2024-10-11
First Publication Date 2025-03-13
Owner Genentech, Inc. (USA)
Inventor
  • Blake, Robert Anthony
  • Dragovich, Peter
  • Gazzard, Lewis J.
  • Kaufman, Susan
  • Kleinheinz, Tracy
  • Pillow, Thomas
  • Staben, Steven T.
  • Wei, Binqing

Abstract

The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.

IPC Classes  ?

83.

NEW PROP-2-YNAMIDE DERIVATIVES

      
Application Number EP2024074776
Publication Number 2025/051829
Status In Force
Filing Date 2024-09-05
Publication Date 2025-03-13
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Brandstaetter, Marco
  • Kuhn, Bernd Willi
  • Mueller, Barbara Johanna
  • Ricci, Antonio
  • Tosstorff, Andreas Michael
  • Zambaldo, Claudio

Abstract

133 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

IPC Classes  ?

  • C07D 207/08 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
  • A61P 35/00 - Antineoplastic agents
  • C07C 233/05 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
  • C07D 205/02 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
  • C07D 211/14 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
  • C07D 295/10 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulfur atoms
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond

84.

LABORATORY DEVICE AND LABORATORY SYSTEM

      
Application Number EP2024074823
Publication Number 2025/051852
Status In Force
Filing Date 2024-09-05
Publication Date 2025-03-13
Owner
  • ROCHE DIAGNOSTICS GMBH (Germany)
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • ROCHE DIAGNOSTICS OPERATIONS, INC. (USA)
Inventor Eicher, Patrick

Abstract

The invention relates to a laboratory device (1) for handling laboratory sample container racks (50), the laboratory device (1) comprising a base (2) extending horizontally, the base (2) being adapted to support laboratory sample container racks (50) placed thereon, a first finger (3) being movable relative to the base (2), the first finger (3) being adapted to position a laboratory sample container rack (50) on the base (2), a second finger (4) being adapted to horizontally counteract the first finger (3) so that the laboratory sample container rack (50) positioned on the base (2) is holdable in between the first finger (3) and the second finger (4), a down-holder (5) being movable relative to the base (2), the down-holder (5) being adapted to releasably vertically secure the laboratory sample container rack (50) positioned on the base (2), and a linkage (6) which motion-couples the first finger (3) and the second finger (4) and the down-holder (5) to one another.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
  • B01L 9/06 - Test-tube standsTest-tube holders
  • B65G 65/00 - Loading or unloading
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Details of the conveyor system

85.

TRANSFER DEVICE AND TRANSFER METHOD FOR TRANSFERRING AT LEAST ONE VOLUME OF A CELL SUSPENSION

      
Application Number EP2024074703
Publication Number 2025/051789
Status In Force
Filing Date 2024-09-04
Publication Date 2025-03-13
Owner ROCHE DIAGNOSTICS GMBH (Germany)
Inventor
  • Eckl, Markus
  • Eybel, Florian

Abstract

A transfer method and a transfer device (110) for transferring at least one volume of a cell suspension from a first sample tube (112) to a second sample tube (114) are disclosed. The transfer device (110) comprises: - at least one first cannula (116) configured for transferring the at least one volume of the cell suspension from the first sample tube (112) to the second sample tube (114), wherein the first cannula (116) comprises at least one first cannula tip (118) configured for at least partially penetrating into an interior (120) of the first sample tube (112), wherein the first cannula (116) further comprises at least one second cannula tip (122) configured for at least partially penetrating into an interior (124) of the second sample tube (114), wherein the first cannula tip (118) and the second cannula tip (122) are in direct fluidic connection (126) with each other, enabling a transfer of the at least one volume of the cell suspension from the first sample tube (112) to the second sample tube (114); and - at least one second cannula (130) configured for providing at least one pressure port (132) to the interior (120) of the first sample tube (112).

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

86.

HIGH VISCOSITY ULTRAFILTRATION/DIAFILTRATION AND SINGLE-PASS TANGENTIAL FLOW FILTRATION PROCESSES

      
Application Number US2024045496
Publication Number 2025/054398
Status In Force
Filing Date 2024-09-06
Publication Date 2025-03-13
Owner GENENTECH, INC. (USA)
Inventor
  • Sackett, Benjamin Mark
  • Keba, James J.

Abstract

The present disclosure provides high viscosity ultrafiltration/diafiltration (UF/DF) and single pass tangential flow filtration (SPTFF) processes used in the purification of polypeptides. A method for purifying a polypeptide from a polypeptide preparation may include the following steps in order: a) subjecting the polypeptide preparation to one or more purification processes and recovering a first resulting pool having a viscosity of about 5-40 cP; and b) subjecting the pool recovered from step a) to a SPTFF operation comprising use of membranes in either or both a serial membrane and/or a parallel membrane configuration and recovering a second resulting pool having an operating viscosity of about 41-400 cP, wherein, i) the operating temperature is about 15-55°C, and ii) the feed flux is about 5-50 L/m2/hr (LMH).

IPC Classes  ?

  • C07K 1/34 - ExtractionSeparationPurification by filtration, ultrafiltration or reverse osmosis
  • C07K 1/36 - ExtractionSeparationPurification by a combination of two or more processes of different types

87.

EVOAMP

      
Application Number 019154772
Status Pending
Filing Date 2025-03-11
Owner Roche Diagnostics GmbH (Germany)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Biological preparations, other than for medical or veterinary purposes; Biochemical preparations for scientific purposes; Diagnostic reagents for scientific or research use; Reagents for use in scientific apparatus for chemical or biological analysis; Chemical substances for analyses in laboratories, other than for medical or veterinary purposes; Nucleic acids for scientific purposes; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Chemical reagents for use in genetic research.

88.

FENLYQO

      
Application Number 1842368
Status Registered
Filing Date 2024-12-20
Registration Date 2024-12-20
Owner F. Hoffmann-La Roche AG (Switzerland)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations.

89.

NOVEL HETEROARYL COMPOUNDS

      
Application Number 18710702
Status Pending
Filing Date 2022-11-17
First Publication Date 2025-03-06
Owner
  • ICAGEN, LLC (USA)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Chapman, Mark
  • Davidson, James
  • Davies, Nicholas Gareth Morse
  • Gerlach, Aaron
  • Graham, Christopher John
  • Lebreton, Sylvain
  • Li, Ronghua
  • Ma, Nina
  • Mechin, Ingrid
  • Mowrey, David
  • Nagarajan, Karthigeyan
  • Nair, Anil
  • Norcross, Roger David
  • Redondo Pena, Roger Lluis
  • Safarova, Alena
  • Smrcina, Martin

Abstract

The invention provides new heteroaromatic compounds having the general formula (I′), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds. The invention provides new heteroaromatic compounds having the general formula (I′), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

IPC Classes  ?

  • C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
  • A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
  • A61K 31/4427 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems
  • A61K 31/443 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
  • A61K 31/4433 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
  • A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
  • A61K 31/50 - PyridazinesHydrogenated pyridazines
  • A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
  • A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
  • A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
  • A61K 31/695 - Silicon compounds
  • C07D 213/56 - Amides
  • C07D 213/61 - Halogen atoms or nitro radicals
  • C07D 213/64 - One oxygen atom attached in position 2 or 6
  • C07D 213/70 - Sulfur atoms
  • C07D 213/84 - Nitriles
  • C07D 237/14 - Oxygen atoms
  • C07D 239/34 - One oxygen atom
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 493/08 - Bridged systems
  • C07F 7/08 - Compounds having one or more C—Si linkages

90.

Immunoconjugates

      
Application Number 18746802
Status Pending
Filing Date 2024-06-18
First Publication Date 2025-03-06
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Codarri Deak, Laura
  • Klein, Christian
  • Lauener, Laura
  • Nicolini, Valeria G.
  • Seeber, Stefan
  • Umaña, Pablo
  • Waldhauer, Inja

Abstract

The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.

IPC Classes  ?

  • A61K 38/20 - Interleukins
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • A61P 35/00 - Antineoplastic agents
  • C07K 14/55 - IL-2
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

91.

SYNTHESIS OF QUINAZOLINE COMPOUNDS

      
Application Number 18946050
Status Pending
Filing Date 2024-11-13
First Publication Date 2025-03-06
Owner
  • Genentech, Inc. (USA)
  • Hoffmann-La Roche Inc. (USA)
Inventor
  • Lim, Ngiap-Kie
  • Shen, Jeff
  • Sirois, Lauren Elizabeth
  • Timmerman, Jacob C.
  • Trachsel, Etienne
  • White, Nicholas Andrew
  • Xu, Jie
  • Zhang, Haiming
  • Bachmann, Stephan
  • Bigler, Raphael
  • Clagg, Kyle Bradley Pascual
  • Dipasquale, Antonio Giovanni
  • Gosselin, Francis
  • Orcel, Ugo Jonathan
  • Meier, Roland Christoph

Abstract

Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

IPC Classes  ?

  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

92.

PYRAZOLE DERIVATIVES AS STING AGONISTS

      
Application Number 18947305
Status Pending
Filing Date 2024-11-14
First Publication Date 2025-03-06
Owner Hoffmann-La Roche Inc. (USA)
Inventor
  • Liu, Haixia
  • Liu, Yafei
  • Wang, Jianping
  • Wu, Yao
  • Zhang, Zhiwei

Abstract

The present invention provides novel compounds having the general formula: The present invention provides novel compounds having the general formula: The present invention provides novel compounds having the general formula: wherein ring A, ring B, ring C, bond a, and R1 to R7 are as described herein, or a pharmaceutically acceptable salt thereof, compositions including the compounds and methods of using the compounds.

IPC Classes  ?

  • C07D 487/04 - Ortho-condensed systems
  • A61K 9/20 - Pills, lozenges or tablets
  • A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
  • A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
  • A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
  • A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
  • A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 471/04 - Ortho-condensed systems

93.

METHODS OF USING ANTI-CD79b IMMUNOCONJUGATES

      
Application Number 18661293
Status Pending
Filing Date 2024-05-10
First Publication Date 2025-03-06
Owner Genentech, Inc. (USA)
Inventor
  • Polson, Andrew
  • Yu, Shang-Fan
  • Chu, Yu-Waye
  • Wenger, Michael
  • Hirata, Jamie Harue
  • Lu, Dan

Abstract

Provided herein are methods of treating B-cell proliferative disorders in particular Follicular Lymphoma and/or Diffuse Large B-Cell Lymphoma using immunoconjugates comprising anti-CD79b antibodies in combination with additional therapeutic agents.

IPC Classes  ?

  • A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
  • A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
  • A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
  • A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

94.

THERAPEUTIC COMPOUNDS AND METHODS OF USE

      
Application Number 18823182
Status Pending
Filing Date 2024-09-03
First Publication Date 2025-03-06
Owner Genentech, Inc. (USA)
Inventor
  • Zbieg, Jason Robert
  • Smith, Russell Tyler
  • Beroza, Paul Powell
  • Verma, Vishal Anil
  • Zhu, Bing-Yan
  • Beveridge, Ramsay
  • Barton, Lisa Marie
  • Chan, Bryan Ka Ip
  • Colwell, Curtis
  • Bouayad-Gervais, Samir
  • Dey, Anwesha
  • Evangelista, Marie Anne

Abstract

This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

IPC Classes  ?

95.

AUTOMATED INFORMATION EXTRACTION AND ENRICHMENT IN PATHOLOGY REPORT USING NATURAL LANGUAGE PROCESSING

      
Application Number 18939395
Status Pending
Filing Date 2024-11-06
First Publication Date 2025-03-06
Owner Roche Molecular Systems, Inc. (USA)
Inventor
  • Sharma, Vishakha
  • Pandit, Yogesh
  • Balasubramanian, Ram

Abstract

In one example, a method being performed by a computer system comprises: receiving an image file containing a pathology report; performing an image recognition operation on the image file to extract input text strings; detecting, using a natural language processing (NLP) model, entities from the input text strings, each entity including a label and a value; extracting, using the NLP model, the values of the entities from the input text strings; converting, based on a mapping table that maps entities and values to pre-determined terminologies, the values of at least some of the entities to the corresponding pre-determined terminologies; and generating a post-processed pathology report including the entities detected from the input text strings and the corresponding pre-determined terminologies.

IPC Classes  ?

  • G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
  • G06F 40/20 - Natural language analysis
  • G06F 40/279 - Recognition of textual entities
  • G06V 30/30 - Character recognition based on the type of data
  • G06V 30/416 - Extracting the logical structure, e.g. chapters, sections or page numbersIdentifying elements of the document, e.g. authors
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

96.

METHOD FOR THE GENERATION OF SINGLE STRANDED DNA

      
Application Number EP2024073796
Publication Number 2025/045810
Status In Force
Filing Date 2024-08-26
Publication Date 2025-03-06
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Kappaun, Fiona
  • Manz, Julia
  • Pschirer, Johannes Anton
  • Ruppert, Raphael

Abstract

The present invention relates to a method for the generation of single stranded DNA (ssDNA) molecules from circular double stranded DNA (dsDNA) molecules.

IPC Classes  ?

  • C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease

97.

TREATMENT OF NON SMALL CELL LUNG CANCER WITH ALECTINIB

      
Application Number EP2024073974
Publication Number 2025/045901
Status In Force
Filing Date 2024-08-28
Publication Date 2025-03-06
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Archer, Venice Rosalie
  • Bordogna, Walter
  • Cardona Gavaldon, Andres
  • Golding, Sophie Maude Alice
  • Maudire Épouse Hilton, Magalie
  • Noé, Johannes Alexander
  • Ochi Lohmann, Tania Helena
  • Ruf, Thorsten
  • Xu, Tingting
  • Zeaiter, Ali

Abstract

The present invention relates to a method of treating anaplastic lymphoma kinase (ALK)- positive non-small cell lung cancer (NSCLC), comprising administering to a subject in need of such treatment a therapeutically effective amount of alectinib, or a pharmaceutically acceptable salt thereof, wherein the subject has resected stage Ib ALK-positive NSCLC with a tumour greater or equal to 4cm to stage IIIa ALK-positive NSCLC.

IPC Classes  ?

  • A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 35/00 - Antineoplastic agents

98.

INHIBITORS OF THE NLRP3 INFLAMMASOME

      
Application Number EP2024074103
Publication Number 2025/045961
Status In Force
Filing Date 2024-08-29
Publication Date 2025-03-06
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Bouche, Lea Aurelie
  • Guba, Wolfgang
  • Herr, Sabrina
  • Jaeschke, Georg
  • Mesch, Stefanie Katharina
  • Schnider, Christian
  • Steiner, Sandra

Abstract

xyy are as described herein, composition including the compounds and methods of using the compounds.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
  • A61P 11/06 - Antiasthmatics
  • A61P 11/08 - Bronchodilators
  • A61P 25/16 - Anti-Parkinson drugs
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

99.

CONTAINER INTEGRITY TESTING SYSTEM AND METHOD

      
Application Number EP2024074154
Publication Number 2025/045990
Status In Force
Filing Date 2024-08-29
Publication Date 2025-03-06
Owner
  • F. HOFFMANN-LA ROCHE AG (Switzerland)
  • HOFFMANN-LA ROCHE INC. (USA)
Inventor
  • Abel, Lars
  • Proff, Christian

Abstract

A CCI testing system (1) to test closure integrity of a container (2) with a hollow interior (223), an outlet (221), an open end (222) and a stopper (21) arranged to close the hollow interior (223), comprises a container holder (13), a test gas supply (171), a test gas detector (11) and a chamber (14). The container holder (13) is configured to tightly receive a first aperture being one of the open end (222) of the container (2) or the outlet (221) of the container (2). The test gas supply (171) comprises a test gas. The test gas detector (11) is tightly coupled to the container holder (13) and configured to detect test gas exiting the first aperture when being received by the container holder (13). The chamber (14) is coupled to the container holder (13) to form an encasing of a second aperture being the other one of the open end (222) of the container (2) or the outlet (221) of the container (2) when the first aperture is received by the container holder (13). The test gas supply (171) is coupled to the chamber (14). The test gas detector (11) is configured to apply a subatmospheric pressure to the container holder (13) and the container holder (13) is configured to effect the subatmospheric pressure to the first aperture. The test gas supply (171) is configured to supply test gas into the chamber (14). The chamber (14) has an exhaust outlet (141). The chamber (14) is configured to expose the second aperture to a gas flow generated by the test gas supply (171) supplying test gas into the chamber (14) and out of the chamber (14) via the exhaust outlet (141), when the first aperture is received by the container holder (13).

IPC Classes  ?

  • G01M 3/20 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material
  • G01M 3/22 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for valves
  • G01M 3/28 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for valves

100.

TERTIARY PYRIDYL AMINE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYLINATION

      
Application Number US2024044067
Publication Number 2025/049495
Status In Force
Filing Date 2024-08-27
Publication Date 2025-03-06
Owner
  • GENENTECH, INC. (USA)
  • CONVELO THERAPEUTICS, INC. (USA)
Inventor
  • Braun, Marie-Gabrielle
  • Castanedo, Georgette Marie
  • Dorel, Ruth
  • Liang, Jun
  • Ung, Man Un
  • Carruthers, Nicholas
  • Factor, Daniel
  • Adams, Drew

Abstract

The subject matter described herein is directed to myelin-promoting compounds of Formula A and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

IPC Classes  ?

  • C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
  • C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
  • C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
  • A61K 31/4427 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems
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