Abstract

A preparation method for a biapenem active ingredient, comprising: 1) dissolving crude biapenem in water to prepare an aqueous solution; 2) adding activated carbon, stirring for decolorization, filtering, and cooling the filtrate for use; 3) adding the filtrate dropwise in a pre-cooled mixed solvent of acetone and ethanol, and crystallizing; 4) growing crystals; and 5) separating, washing, and drying the precipitated crystals to obtain a biapenem active ingredient.

IPC Classes  ?

• C07D 519/06 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or containing at least one condensed beta-lactam ring system, provided for by groups , or , e.g. a penem or a cepham system

Abstract

Provided is a preparation method for N-trimethylsilylimidazole, said method comprising the following steps: 1) under the protection of inert gas, heating imidazole and hexamethyldisilazane to T1, and allowing to react for 1-4 hours; 2) after completing step 1, cooling the reaction system to 30-50°C, evacuating until the vacuum degree is V1, heating to T2, performing distillation at reduced pressure, and collecting a front fraction D1 below 90°C; 3) after completing step 2, heating the reaction system to T3, and collecting a fraction D2 at 95-105°C; after completing step 3, the residual in the reaction system is imidazole.

IPC Classes  ?

• C07F 7/10 - Compounds having one or more C—Si linkages containing nitrogen