Abrégé

A preparation method for a biapenem active ingredient, comprising: 1) dissolving crude biapenem in water to prepare an aqueous solution; 2) adding activated carbon, stirring for decolorization, filtering, and cooling the filtrate for use; 3) adding the filtrate dropwise in a pre-cooled mixed solvent of acetone and ethanol, and crystallizing; 4) growing crystals; and 5) separating, washing, and drying the precipitated crystals to obtain a biapenem active ingredient.

Classes IPC  ?

• C07D 519/06 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou contenant au moins un système cyclique bêta-lactame condensé prévu par les groupes , ou , p. ex. un système pénème ou un système céphame

Abrégé

Provided is a preparation method for N-trimethylsilylimidazole, said method comprising the following steps: 1) under the protection of inert gas, heating imidazole and hexamethyldisilazane to T1, and allowing to react for 1-4 hours; 2) after completing step 1, cooling the reaction system to 30-50°C, evacuating until the vacuum degree is V1, heating to T2, performing distillation at reduced pressure, and collecting a front fraction D1 below 90°C; 3) after completing step 2, heating the reaction system to T3, and collecting a fraction D2 at 95-105°C; after completing step 3, the residual in the reaction system is imidazole.

Classes IPC  ?

• C07F 7/10 - Composés comportant une ou plusieurs liaisons C—Si azotés