Abstract

The present invention provides a method for synthesizing an atorvastatin calcium intermediate by using a multi-component one-pot method. Specifically, the present invention provides a one-pot synthesis method for 4-(4-fluorophenyl)-2-(2-methylpropanoyl)-3-phenyl-4-oxo-N-phenylbutanamide. The one-pot synthesis method is characterized in that a target compound is synthesized from N-phenyl phenylpropiolamide and 4-fluorobenzaldehyde and isobutyraldehyde in the one-pot method under the action of Cu(SbF6)2 and a Pd-ligand catalyst. The one-pot method complies with the characteristics of green chemistry and high atom economy, and significantly reduces the emission of waste water, waste gas, solid waste and pollution factors; has fewer reaction steps and a yield (about 80% to 87%) which is significantly higher than that of the existing multi-step synthesis method technical solutions; has raw materials which are easy to obtain and simple and convenient process operations; has a low risk of EHS; and has high industrial feasibility.

IPC Classes  ?

• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
• C07C 235/80 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
• B01J 31/22 - Organic complexes
• C07D 273/04 - Six-membered rings
• C07C 239/18 - Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups