Abstract

The subject invention pertains to hexacyclic xanthones isolated from marine bacteria. These chrexanthomycins are effective TRPV1 inhibitors that are effective as analgesics.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A process involves adding charged fibers with surface-cured “temperature-sensitive gel” during the preparation of concrete; preparing charged fibers with surface-cured “temperature-sensitive gel” by spraying, which envelops the charged fibers with a layer of “temperature-sensitive gel”; then solidifying the temperature-sensitive gel layer on the surface of the charged fibers by adjusting the environmental temperature. Utilizing the physical state of the temperature-sensitive gel at different temperatures, the “temperature-sensitive gel” wraps around the charged fibers to form an insulating layer. This prevents the scattering of the charged fibers due to charge repulsion during their introduction into the concrete preparation process, ensuring they are evenly distributed.

IPC Classes  ?

• C04B 20/10 - Coating or impregnating
• B05B 12/02 - Arrangements for controlling deliveryArrangements for controlling the spray area for controlling time, or sequence, of delivery
• B28C 5/40 - Mixing specially adapted for preparing mixtures containing fibres
• C04B 14/04 - Silica-rich materialsSilicates
• C04B 14/06 - QuartzSand
• C04B 22/06 - OxidesHydroxides
• C04B 28/08 - Slag cements
• C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
• D06M 15/03 - Polysaccharides or derivatives thereof

Abstract

Provided are a modified mu-conotoxin, a preparation method therefor, and a use thereof. Amino acid residue modification is performed on the basis of wild-type μ-conotoxin PIIIA, so that the blocking effect of μ-conotoxin on a sodium channel is moderately weakened, meanwhile, the stability is maintained under both acidic and alkaline conditions, and isoelectric point stability and target specificity are maintained. The provided modified mu-conotoxin has the characteristics such as stability and low production costs. The modified mu-conotoxin maintains a good anti-wrinkle function, and the modified mu-conotoxin can be used to prevent facial muscle stiffness and paralysis caused by excessive inhibition of skeletal muscle sodium channel Nav1.4; meanwhile, the risk of inhibiting a myocardial sodium channel and a brain sodium channel is remarkably reduced, and transmembrane absorption is facilitated.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61Q 19/08 - Anti-ageing preparations
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 21/02 - Muscle relaxants, e.g. for tetanus or cramps

Abstract

Embodiments of the present invention relate to a drift prediction method and apparatus of a floating object, a computing device, and a storage medium. The embodiments of the present invention provide a drift speed prediction method, comprising: obtaining environment characteristic parameters of a position where a floating object to be predicted is located, the environment characteristic parameters comprising wave characteristic parameters; and inputting the wave characteristic parameters into a pre-trained wave-induced drift deep learning model to obtain a wave-induced drift speed, wherein the wave-induced drift deep learning model is obtained by training on the basis of first sample drift data, and the first sample drift data comprises a sample drift speed observation value of a sample floating object, a corresponding sample surface layer water flow characteristic parameter, a sample wind characteristic parameter and a sample wave characteristic parameter. By predicting the wave-induced drift speed, a drift speed of the floating object to be predicted can be predicted more accurately, and then a drift path of the floating object to be predicted can be predicted more accurately.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

Abstract

The embodiments of the present disclosure relate to a wind-induced drift prediction method and apparatus, and a device and a storage medium. A drift prediction method for a floating object comprises: acquiring environmental parameters at the position where a floating object is located; according to the environmental parameters, determining a predicted drift deviation at the position where the floating object is located, wherein the predicted drift deviation is the deviation of a predicted wind-induced drift direction of the floating object relative to a wind direction; selecting a corresponding wind-induced drift coefficient according to the predicted drift deviation; and determining a wind-induced drift speed of the floating object according to the wind-induced drift coefficient. By using the drift prediction method for a floating object provided in the present solution, a drift deviation can be determined on the basis of environmental parameters, and a wind-induced drift speed is then calculated, instead of randomly determining a drift deviation and calculating a wind-induced drift speed in the prior art, such that the wind-induced drift speed of a floating object to be predicted can be predicted more accurately.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

A gas powered-type wave energy power supply subsurface buoy, which comprises a spindle-shaped subsurface buoy body (1); two ends of a Y-shaped armored optic-electric composite cable (16) are mounted at two ends of a short axis of the subsurface buoy body (1); a third end of the Y-shaped armored optic-electric composite cable (16) is connected to one end of a vertical armored optic-electric composite cable (17); the other end of the vertical armored optic-electric composite cable (17) is connected to a sunken anchoring block (18); a gas power loop electricity generation unit is mounted inside the subsurface buoy body (1); and a plane where the gas power loop electricity generation unit is located is perpendicular to the short axis of the subsurface buoy body (1).

IPC Classes  ?

• F03B 13/24 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy to produce a flow of air, e.g. to drive an air turbine

Abstract

A self-cleaning and anti-adhesion apparatus for marine instruments includes an installation frame. A first end of the installation frame is fixed with an installation base, and a second end of the installation frame is movable with a screw rod. The upper end of the installation base is movable with a first rotation base. A wire netting ball used for holding a sensor is installed above the first rotation base. The wire netting ball is fixedly connected with the installation base. The top end of the screw rod is fixedly connected with a first end of the flexible connector, and a second end of the flexible connector is fixedly connected with a floating bladder. The screw rod is screwed with an inner wheel of an internal meshing ratchet mechanism, and an outer wheel of the internal meshing ratchet mechanism is fixed inside the mounting ring.

IPC Classes  ?

• B08B 1/04 - Cleaning by methods involving the use of tools, brushes, or analogous members using rotary operative members
• B08B 1/00 - Cleaning by methods involving the use of tools
• B63B 59/08 - Cleaning devices for hulls of underwater surfaces while afloat

Abstract

A wave power generation glider and a working method therefor. The wave power generation glider comprises a floating body (1) and a wave glider which are connected by means of a traction rope assembly (2); a communication device (3), a positioning device (4), a control device (5), a power storage device (6), and an energy converter are arranged in the floating body (1), and the communication device (3), the positioning device (4), and the power storage device (6) are separately connected to the control device (5); the wave glider comprises a glider body (7), a plurality of wave power generation mechanisms (8) are disposed on two sides of the glider, the plurality of wave power generation mechanisms (8) are separately connected to the energy converter, and the energy converter is connected to the power storage device (6); each wave power generation mechanism comprises a rotating shaft, and two ends of the rotating shaft are respectively movably connected to the glider body (7) and a wing plate (11); each rotating shaft comprises a sleeve (9) and a movable rod (10) which is telescopic in the sleeve (9), and the corresponding wing plate (11) is connected to the movable rod (10). The wave power generation glider may implement gliding and power generation.

IPC Classes  ?

• F03B 13/20 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy using the relative movement between a wave-operated member and another member wherein both members are movable relative to the sea bed or shore
• F03B 11/00 - Parts or details not provided for in, or of interest apart from, groups
• B63H 19/04 - Marine propulsion not otherwise provided for by using energy derived from movement of ambient water, e.g. from rolling or pitching of vessels propelled by water current
• B63H 21/17 - Use of propulsion power plant or units on vessels the vessels being motor-driven by electric motor
• B63B 35/00 - Vessels or similar floating structures specially adapted for specific purposes and not otherwise provided for

Abstract

A marine float capable of avoiding marine hazards such as typhoons, and avoidance method thereof. The float comprises a float body (1). A cavity (2) is formed in the middle of the float body (1). An air bag (3) for driving the float body (1) to float after being inflated is arranged in the cavity (2). An air pipe (4) is installed at the top of the air bag (3). The top of the air pipe (4) extends to the outside of the float body (1). An air valve (5) is installed at the top of the air pipe (4). The arrangement height of the top of the air valve (5) is higher than that of the top of the float body (1). The bottom of the cavity (2) is provided with a normally open water passing pipe (6). The float is simple in structure and can reduce the probability of being completely destroyed by marine hazards such as typhoons.

IPC Classes  ?

• B63B 43/12 - Improving safety of vessels, e.g. damage control, not otherwise provided for reducing risk of capsizing or sinking by improving buoyancy using inboard air containers
• B63B 22/18 - Buoys having means to control attitude or position, e.g. reaction surfaces or tether

Abstract

A deep-sea in-situ long-term experimental platform having a sediment sampling function, which relates to the field of deep sea apparatuses. The platform enables, by means of a multi-stage release mechanism, buoyancy to match gravity to complete an entire sampling recovery process of sediment, which only requires small power units to be sequentially triggered to complete intubation and sampling without a powerful power source to provide kinetic energy for vertical movement. The structure of the deep-sea in-situ long-term experimental platform is simplified, and moreover, the weight is reduced, the cost is reduced, and the reliability is further improved.

IPC Classes  ?

• G01N 1/12 - DippersDredgers
• B63B 35/00 - Vessels or similar floating structures specially adapted for specific purposes and not otherwise provided for

Abstract

Disclosed in the present invention is an intelligent solution injection device for a deep-sea sediment microorganism culture experiment. The intelligent solution injection device is mainly composed of an insertion device, a controllable slow-release solution injection system, an interstitial water displacement and monitoring system, and a deep-sea peristaltic pump. The insertion device can insert a solution injection needle tube and an interstitial water collection tube into a designated sediment position by means of gravity or other driving devices; the controllable slow-release solution injection system is used for receiving an instruction to inject a certain amount of culture solution into sediment through the solution injection needle tube; and the interstitial water displacement and monitoring system is used for collecting sediment interstitial water and monitoring environmental parameters to develop a solution injection policy. The present invention can simulate a diffusion process of matter seeping out of a deep-sea cold seep, and can provide a powerful tool for researchers to conduct long-term in-situ experiments of deep-sea sediment microorganisms.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The present invention provides potent antibiofilm and antifouling compounds albofungin and derivatives thereof isolated from Streptomyces chrestomyceticus BCC 24770, the construction of high-yield strains for albofungin production, and application of albofungin-based copolymer coatings to object or surfaces, particularly to inhibit fouling by marine organisms using hydrolysable and degradable antifouling coatings incorporated with albofungins.

IPC Classes  ?

• C09D 5/16 - Anti-fouling paintsUnderwater paints
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 143/04 - Homopolymers or copolymers of monomers containing silicon

Abstract

Disclosed in the present application are a novel double-sided solid culture dish and use thereof, which relate to the fields of microculture, etc. The culture dish comprises an upper cover and a lower cover, a straight cylinder dish wall being arranged between the upper cover and the lower cover, and the upper cover, the lower cover and the straight cylinder dish wall forming a snap-fit structure; and a gauze type permeable membrane base, a grid-shaped fixing structure being arranged on the gauze type permeable membrane base, and "T"-shaped column structures being vertically arranged on joints or grid lines of the grid-shaped fixing structure. Culture dishes are formed between the gauze type permeable membrane base and the upper cover, and between the gauze type permeable membrane base and the lower cover respectively, and a solidified culture medium is made into the stable double-sided solid culture dish since the "T"-shaped column structures on the gauze type permeable membrane base and a circle of boss structure perpendicular to the wall of the straight cylinder dish wall jointly support a solid culture medium to be not separated from the gauze type permeable membrane base. According to the culture dish, double-sided preparation and the use of the solid culture medium and information exchange and interaction of double-sided microorganisms are achieved, such that related researches of non-contact interaction between microorganisms or interaction between the microorganisms and an environment become simple, convenient, rapid and efficient.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 1/22 - Petri dishes
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The subject invention pertains to compositions comprising albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo. The subject invention further pertains to methods of treating a subject with HIV using albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo.

IPC Classes  ?

• C07D 491/052 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
• C07D 491/16 - Peri-condensed systems
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61P 31/18 - Antivirals for RNA viruses for HIV

Abstract

A self-cleaning anti-adhesion apparatus for a marine instrument, comprising a mounting frame (1), wherein one end of the mounting frame (1) is fixedly provided with a mounting seat (2), the other end of the mounting frame (1) is movably provided with a screw rod (3), and the upper end of the mounting seat (2) is movably provided with a first rotating seat (4); a metal mesh ball (5) used for accommodating a sensor is mounted above the first rotating seat (4), and the metal mesh ball (5) is fixedly connected to the mounting seat (2); the top end of the screw rod (3) is fixedly connected to one end of a flexible connecting piece (6), and the other end of the flexible connecting piece (6) is fixedly connected to a floating bag (7); the screw rod (3) is in threaded connection with an inner wheel of an internally engaged ratchet mechanism (8), an outer wheel of the internally engaged ratchet mechanism (8) is movably mounted on the inner side of a mounting ring (9), and the mounting ring (9) is fixedly connected to the mounting frame (1); the outer wheel of the internally engaged ratchet mechanism (8) is fixedly connected to a second rotating seat (10); a rotating ring (11) is fixedly arranged between the first rotating seat (4) and the second rotating seat (10), and the inner wall of the rotating ring (11) is provided with a brush (12); the rotating ring (11) can be driven by the upper buoyancy of natural wave energy to clean the outer wall of the metal mesh ball (5) without other energy sources, which ensures that the sensor mounted in the metal mesh ball (5) is not obstructed.

IPC Classes  ?

• G01D 11/00 - Component parts of measuring arrangements not specially adapted for a specific variable
• G01D 3/08 - Measuring arrangements with provision for the special purposes referred to in the subgroups of this group with provision for safeguarding the apparatus, e.g. against abnormal operation, against breakdown
• B08B 1/04 - Cleaning by methods involving the use of tools, brushes, or analogous members using rotary operative members

Abstract

The subject invention pertains to compositions and methods of coating objects using BOC-butenolide. The invention also relates to compositions and methods for enhancing the performance and longevity of the coated objects with BOC-butenolide, including inhibiting fouling often caused by marine organisms.

IPC Classes  ?

• A01N 47/12 - Carbamic acid derivatives, i.e. containing the group —O—CO—NThio-analogues thereof containing a —O—CO—N group, or a thio-analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
• A01N 25/10 - Macromolecular compounds
• A01P 15/00 - Biocides for specific purposes not provided for in groups
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The subject invention pertains to compositions and methods for treating neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis, epilepsy, stroke, alcohol withdrawal, progressive supranuclear palsy (PSP), Pick's disease (PiD), corticobasal degeneration (CBD), frontotemporal dementia or parkinsonism linked to chromosome 17 (FTDP-17). The methods of the subject invention further relate to methods of fermentation of bacterial cells and methods of tautomerization of the subject compounds.

IPC Classes  ?

• C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 493/04 - Ortho-condensed systems

Abstract

The present application is applicable to the technical field of data processing, and provides a data correction method and apparatus, a terminal device and a storage medium. Said method comprises: determining, according to electromagnetic time sequence data and temperature data which are acquired by submarine electromagnetic acquisition stations, a time period temperature corresponding to the electromagnetic timing data in each time period; determining, according to a preset time correction template, a time error corresponding to each time period temperature, the preset time correction template being used for representing changes in time errors of clocks on the submarine electromagnetic acquisition stations due to the duration of different temperatures; and correcting the electromagnetic time sequence data on the basis of the time error corresponding to each time period temperature. Thus, the clock time of each acquisition station can be corrected, the synchronization accuracy of electromagnetic time sequence data of each acquisition station is ensured, and the application effect of the submarine electromagnetic remote reference synchronization technology is improved.

IPC Classes  ?

• G01V 3/38 - Processing data, e.g. for analysis, for interpretation or for correction

Abstract

The present application is applicable to the technical field of signal processing, and provides a signal processing method and apparatus, a terminal device and a storage medium. The signal processing method comprises: performing signal feature extraction on a submarine electromagnetic detection signal to obtain signal features of the submarine electromagnetic detection signal; and performing, according to the signal features, denoising processing on the submarine electromagnetic detection signal by using a preset signal denoising network, to obtain a denoised submarine electromagnetic detection signal, the signal denoising network being trained by using submarine electromagnetic signal noise samples. Thus, noise and electromagnetic signals in the submarine electromagnetic detection signal can be identified according to the signal features learned by the signal denoising network, and the noise can be removed from the submarine electromagnetic detection signal, so as to specifically perform noise identification and denoising on submarine electromagnetic detection signals in a complex marine environment, thereby optimizing the denoising effect of the submarine electromagnetic detection signals, and effectively improving the quality of the submarine electromagnetic detection signals.

IPC Classes  ?

• G01V 3/12 - Electric or magnetic prospecting or detectingMeasuring magnetic field characteristics of the earth, e.g. declination or deviation operating with electromagnetic waves
• G01V 3/38 - Processing data, e.g. for analysis, for interpretation or for correction
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints