09 - Scientific and electric apparatus and instruments
Goods & Services
Bio-sensors; biochip sensors; barcode readers; bar code
printers; portable scanners; radio-frequency identification
(RFID) tags; interfaces for computers; electronic docking
stations; application software for cloud computing services;
cases for tablet computers; cases for data storage devices;
computer software relating to the medical field; computer
software for use in medical decision support systems;
workflow management system software; software as a medical
device [SaMD], downloadable; application software for mobile
devices.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical, biochemical and biological preparations for scientific and research purposes, namely, diagnostic and detection reagents for scientific and research purposes; chemical reagents for research or laboratory use, other than for medical or veterinary use; chemical reagents for the preparation and staining of tissue specimens for research purposes; chemical reagents for non-medical purposes, namely, for use in histological and cytological tissue processing Chemical, biochemical and biological preparations for medical purposes, namely, diagnostic and detection reagents for medical use; in vitro diagnostic reagents for medical use; histology and cytology reagents and staining dyes for preparation and staining of tissue specimens for medical purposes; diagnostic reagents for medical use in the fields of pathology, immunohistochemistry and in situ-hybridization Scientific apparatus, equipment and instruments for performing analyses in laboratories, namely, automated slide staining apparatus for treating and staining tissue slide specimens for laboratory or research use; laboratory equipment, namely, automated sample handling equipment for treating and staining tissue slide specimens for diagnostic use for laboratory or research use; automated laboratory instruments, namely, slide scanners, digital imaging apparatus, microscopes and computer systems comprised of computer hardware and downloadable computer software, all for staining and visualization of tissue or cell based samples for research and scientific use; downloadable computer software for medical and diagnostic purposes, namely, for diagnosing medical disorders; downloadable computer software for the provision of automated diagnostic laboratory processes; downloadable computer software for use with laboratory instruments, namely, for use in providing remote automated control, connection, data analysis, and data management; computer systems comprised of computer hardware and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes; downloadable bioinformatics-enabled medical diagnosis software Medical apparatus and instruments for medical purposes, namely, automated slide staining apparatus for treating and staining tissue specimens for cancer and other tissue-based medical diagnostic testing; diagnostic apparatus for medical purposes, namely, sample preparation device for cancer and other tissue-based medical diagnostic testing; medical apparatus for performing in-vitro diagnostic tests for cancer and other tissue-based diseases; automated slide preparation and staining apparatus for use with tissue slide specimens for medical diagnostic use; medical apparatus and instruments for performing histological and cytological tissue processing and staining for diagnostic purposes
A test carrier system (182) is disclosed. The test carrier system (182) comprises: at least one reaction and measurement cup (184), wherein the reaction and measurement cup (184) is configured for receiving at least one buffer solution (186), wherein the reaction and measurement cup (184) comprises at least one optical window (190) which is received in at least one wall (192) of the reaction and measurement cup (184), the optical window (192) enabling optical analysis of the buffer solution (186); and at least one sample processing unit (110), wherein the sample processing unit (110) is attachable to the reaction and measurement cup (184), wherein the sample processing unit (110) comprises: at least one sample application area (112), wherein the sample application area (112) is configured for receiving at least one sample, wherein the sample application area (112) comprises at least one capillary (114) which opens into an interior space (116) of the sample processing unit (110); and at least one chemical reagent (194), wherein the chemical reagent is received within the interior space (116) of the sample processing unit (110) or within the reaction and measurement cup (184); wherein the test carrier system (182) is configured to be rotatable around a rotation axis (196) of the test carrier system (182) whereby the buffer solution (186) is alternatively transportable to the sample application area (112) or to the chemical reagent (194) depending on at least one of a direction of rotation and a degree of rotation of the test carrier system (182) around the rotation axis (196) of the test carrier system (182).
In a first aspect, the invention relates to a filter element, preferably a blood filter element, comprising (A) a porous film, wherein the porous film comprises at least one film forming polymer and at least one film opener and is free of reactive agents; and (B) a porous support. A second aspect of the invention is directed to a process for preparing a filter element according to the first aspect. In a third aspect, the invention relates to a filter assembly, comprising (I) the filter element of the first aspect; and (II) a spreading member (C). A fourth aspect of the invention is directed to the filter element of the first aspect or the filter assembly of the third aspect, being prepared in the form of a sheet or stripe, preferably cuttable and/or punchable sheet or stripe, from which the filter element or the filter assembly is cut and/or punched in required dimensions, wherein the sheet or stripe has larger dimensions regarding length and width than the filter element or the filter assembly, allowing to cut and/or punch out at least one filter element or filter assembly, wherein in case of a filter assembly, the remaining part of spreading member (C) is optionally removed after cutting and/or punching. A fifth aspect of the invention is related to a method for preparing a filter element of the first aspect or the filter assembly of the third aspect. A sixth aspect of the invention relates to a test carrier system comprising the filter element of the first aspect, and a seventh aspect of the invention is related to a plasma separation and metering unit comprising the filter element of the first aspect. An eight aspect of the invention is directed to the use of the filter element of the first aspect or the plasma separation and metering unit of the seventh aspect for separation of blood plasma from whole blood.
B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
A plasma separation and metering unit (110) is disclosed. The plasma separation and metering unit (110) comprises: • at least one housing (112), wherein the housing (112) comprises at least one receptacle (114) forming at least one sample port (116) for receiving at least one biological sample (168) comprising plasma (174); • at least one plasma separation element (118), wherein the plasma separation element (118) is received in the receptacle (114) of the housing (112), wherein the plasma separation element (118) comprises a sample application side (120) facing the sample port (116) and a plasma side (122) opposing the sample application side (120); and • at least one plasma metering capillary (124) extending from the housing (112), wherein an application end (126) of the plasma metering capillary (124) is fluidically connected to the plasma side (122) of the plasma separation element (118) and is configured for receiving the plasma separated from the biological sample (168) by the plasma separation element (118), wherein an outlet end (128) opposing the application end (126) of the plasma metering capillary (124) comprises an outlet opening (130), and wherein the plasma metering capillary (124) further comprises at least one lateral opening (148) in a capillary wall (132), the lateral opening (148) being located adjacent to the outlet end (128).
The present invention relates to lyo-ready biocompatible solutions and lyophilisates comprising an activeRNaseInh(-SH)n, kits comprising solutions and/or lyophilisates of the present invention and methods of producing solutions and/or lyophilisates of the present invention. The present invention further relates to the use of the herein disclosed solutions, kits and/or lyophilisates for inhibiting an RNase.
A61K 9/19 - Particulate form, e.g. powders lyophilised
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
7.
HIGH AFFINITY ANTIBODIES SPECIFICALLY BINDING TO PEPSINOGEN A
The present invention provides antibodies specifically binding to Pepsinogen A and compositions and kits comprising such antibodies. Furthermore, provided are polynucleotides encoding such antibodies, host cells expressing said antibodies, methods of producing such antibodies and diagnostic methods using such antibodies.
The present invention discloses a new gene fusion which is characteristic for Non- small-cell lung cancer cells and can this be used for specific detection for of Non- small-cell lung tumors.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; biological preparations,
other than for medical or veterinary purposes; biochemical
preparations for scientific purposes; diagnostic reagents
for scientific or research use; reagents for use in
scientific apparatus for chemical or biological analysis;
chemical preparations for analyses in laboratories, other
than for medical or veterinary purposes; nucleic acids for
scientific purposes; diagnostic reagents for in vitro use in
biochemistry, clinical chemistry and microbiology; chemical
reagents for use in genetic research.
10.
IN VITRO DIAGNOSTIC TEST SYSTEM, IVD TEST APPARATUS AND A METHOD OF PERFORMING A MULTIPLEXED DIAGNOSTIC ASSAY AT AN IMPROVED DEGREE OF EFFICIENCY AND ECO-FRIENDLINESS
The invention allows an increased throughput of diagnostic assays and doubles, triples or even further increases the number of assays per cartridge and may therefore be considered as very environmental- and eco-friendly. At the same time, multiple potentially life-saving test results may be provided for one or more patients. The invention relates to an In Vitro diagnostic (IVD) test system (1a, 1b) for performing a multiplexed diagnostic assay, wherein the IVD test system (1a, 1b) comprises: a test carrier (2) comprising a sample application port (3) configured to receive a sample fluid (30); a test zone (4) comprising a shared recessed assay membrane area (4a) and a sample release port (4b) for releasing at least one portion (30, 30a) of the sample fluid (30) to the shared recessed assay membrane area (4a); and a microfluid sample channel system (5) configured to guide the at least one portion (30, 30a) of the sample fluid (30) from the sample application port (3) to the sample release port (4b); the IVD test system (1a, 1b) further comprising: a first assay membrane (6) positioned in the shared recessed assay membrane area (4a) and configured to receive a first part of the at least one portion (30, 30a) of the sample fluid (30) from the sample release port (4b) and to indicate at least one first analyte (31a) in the first part of the at least one portion (30, 30a) of the sample fluid (30); and a second assay membrane (7) positioned in the shared recessed assay membrane area (4a) next to the first assay membrane (6) and configured to receive a second part of the at least one portion (30, 30a) of the sample fluid (30) from the sample release port (4b) and to indicate at least one second analyte (31b) in the second part of the at least one portion (30, 30a) of the sample fluid (30) and/or to indicate the at least one first analyte (31a) in the second part of the at least one portion (30, 30a) of the sample fluid (30) in a different sensitivity range as the first assay membrane (6).
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
11.
TWO NOVEL FUSION TRANSCRIPTS FOR EARLY DETECTION OF NON-SMALL-CELL LUNG CANCER (NSCLC)
The present invention provides a new gene fusion of TPTE2 and MRPS31P2 which is characteristic for Non-small-cell lung cancer cells and can be used for specific detection of Non-small-cell lung tumors.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
chemical, biological and biochemical preparations for scientific and research purposes; chemical substances for analyses in laboratories, not for medical or veterinary purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; biochemical preparations, namely, recombinant human enzymes, for scientific and research purposes; chemical reagents for molecular biology, not for medical or veterinary use chemical, biological and biochemical preparations for medical purposes; in vitro diagnostic reagents for medical purposes; chemical substances for analyses in laboratories for medical purposes; reagents for in-vitro laboratory use for medical purposes; chemical preparations containing enzymes for medical purposes; biochemical preparations, namely, recombinant human enzymes for medical purposes
13.
COMPUTER-IMPLEMENTED METHOD FOR CONTROLLING A MASS SPECTROMETRY ANALYZER SYSTEM
A computer-implemented method for controlling a mass spectrometry analyzer system (110) for analysis of an analyte of interest is proposed. The mass spectrometry analyzer system (110) comprises at least one sample preparation unit, at least one liquid chromatography (LC) unit and at least one mass spectrometer (MS) analyzer unit. The method comprises automatically performing the following steps a) providing at least one experimental plan for at least one unit of the mass spectrometry analyzer system, wherein the experimental plan comprises at least one initial parameter set considering initial knowledge of at least one knowledge database, wherein the initial parameter set comprises at least one control parameter used for performing at least one measurement for analysis of the analyte of interest on said unit, wherein the experimental plan comprises scanning at least partially a parameter space of the control parameter; b) transferring the experimental plan into control instructions for said unit; c) executing the control instructions on said unit, thereby performing at least one measurement in accordance with the experimental plan and obtaining at least one measurement result; d) evaluating the measurement result obtained in step c), wherein the evaluating comprises optimizing the initial parameter set in view of the measurement result, thereby determining an optimized parameter set; and e) storing and/or updating the optimized parameter set in the knowledge database.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Biological preparations, other than for medical or veterinary purposes; Biochemical preparations for scientific purposes; Diagnostic reagents for scientific or research use; Chemical substances for analyses in laboratories, other than for medical or veterinary purposes; Chemical preparations for scientific purposes, other than for medical or veterinary use. Chemical preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Biological preparations for medical purposes.
The present invention relates to a method for detecting an application valve leakage in an analytic system comprising an application valve fluidly connected to an eluent pump, to a trapping column, and to a detector unit, the method comprising (i) applying a sample to the trapping column via the application valve; (ii) applying the sample of step (i) to the detector unit; and (iii) determining at least one sample constituent in the dead time of the analytic system. The present invention also relates to an analytic system comprising an application valve fluidly connected to an eluent pump, a trapping column, and to a detector unit, configured to perform the method according to the present invention, and to methods for quality assurance and uses related thereto.
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
G01M 3/04 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
G01M 3/22 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for valves
The present invention relates to an automated method for determining a particulate compound in a liquid sample, said method comprising (a) dispensing a thin blot aliquot of said sample on a first working area of a substrate; and/or (b) dispensing an overprint aliquot of said sample on a subarea of said first working area; and/or (c) distributing a thick blot aliquot of said sample on a subarea of said first working area and/or on a second working area of the substrate; and (d) determining the particulate compound in said first working area, in said subarea of said first working area, and/or in said second working area, wherein said dispensing comprises translating an applicator tip in relation to the substrate while dispensing the liquid sample through the applicator tip onto the substrate. The present invention further relates to systems and to diagnostic methods related thereto.
The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic biomarker reagents for medical purposes; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic reagents for medical use. Bio-sensors; Biochip sensors; Bar code readers; Bar code printers; Portable scanners; Radio-frequency identification (RFID) tags; Interfaces for computers; Electronic docking stations; Application software for cloud computing services; Bags adapted for laptops; Cases for tablet computers; Cases for data storage devices; Computer software for use in medical decision support systems; Workflow management system software; Software as a medical device [SaMD], downloadable; Application software for mobile devices.
19.
QUALITATIVE TEST FOR DIRECT ORAL ANTICOAGULANTS (DOACS)
The present invention concerns the field of point-of-care diagnostics. In particular, it relates to a method for determining an anticoagulant in a blood sample. The method comprises the following steps: a) providing a composition comprising: i) thrombin or a prothrombin activator converting prothrombin into thrombin that is factor Xa (FXa) inhibitor insensitive, or mixtures thereof; and ii) FXa or a prothrombin activator converting prothrombin into thrombin that is FXa inhibitor sensitive, or mixtures thereof; b) contacting a blood sample with the composition thereby generating a mixture of the composition with the blood sample, wherein the mixture comprises at least 0.01 nkat of thrombin activity and at least 0.05 nkat of FXa activity; c) measuring thrombin activity using a substrate capable of detecting thrombin activity; d) comparing the measured thrombin activity to a reference; and e) determining the anticoagulant based on the comparison. Moreover, the invention contemplates a kit for carrying out such methods, working electrodes of an analyte sensor capable of detecting thrombin activity and analyte sensors comprising the same, as well as a devices for determining an anticoagulant in a blood sample.
A transimpedance amplifier circuit (110) is proposed, comprising at least one transimpedance amplifier (112). The transimpedance amplifier comprises at least one variable feedback resistor (114) and at least one operational amplifier (116). The variable feedback resistor (114) is connected between an input of an operational amplifier (116) and an output of the operational amplifier (116).
A system for quality control of a medical device or software product including a plurality of quality control (QC) modules, each QC module configured for one or more QC task(s) of a QC process and configured for access by a plurality of users assigned roles and responsibilities for the respective QC task(s), the quality control library configured to store a plurality of QC records including information associated with the QC task(s) and governmental rule(s) or regulation(s) applicable to the respective QC module and medical device product.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G06Q 10/0639 - Performance analysis of employeesPerformance analysis of enterprise or organisation operations
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; chemical reagents for use in genetic research.
23.
METHOD AND SYSTEM FOR APPLYING A LIQUID SAMPLE ONTO A SUBSTRATE FOR IMAGE ANALYSIS
The present disclosure relates to an automated method for applying a liquid sample (1) onto a substrate (2) for image analysis as well as an automated system (100) for performing the automated method. The automated method comprises providing data corresponding to a property of the liquid sample (1) from a property determination unit (20) to a workflow management unit (90); selecting, by the workflow management unit (90), sample preparation operations based on the property of the liquid sample (1); setting, by the workflow management unit (90), operational parameters based on the selected sample preparation operations and/or on the property of the liquid sample (1); controlling a sample preparation unit (10) to prepare the liquid sample (1) for image analysis by performing the sample preparation operations selected by the workflow management unit (90) and by using the operational parameters set by the workflow management unit (90).
In one general aspect, the present disclosure relates to an analytical analyzer (100) including a sample support (107) defining a sample area, an illumination assembly (109) configured to illuminate the sample area with illumination light (9), a matrix detector (6) and a detection assembly (111) configured to image light (7) emitted from the sample area onto the matrix detector (6). The analytical analyzer (100) further includes a field lens array including a plurality of field lens elements (202) arranged over the sample area so that the illumination light (9) and the light (7) emitted from the sample traverses through the field lens array (18) and an opaque grid (103) arranged to cover the edges of each of the plurality of field lens elements (202).
The present invention refers, inter alia, to a method of determining the amount of cardiac Troponin T (cTnT) in a sample, said method comprising a) contacting the sample with an anti-cTnT antibody and with an antibody against skeletal Troponin T (anti-skTnT antibody), wherein the anti-cTnT antibody is capable of binding to a cTnT peptide sequence conserved between cTnT and skTnT, wherein the anti-skTnT antibody is not capable of binding to said conserved cTnT peptide sequence, and wherein the anti-skTnT antibody is capable of binding to a skTnT peptide sequence conserved between skTnT and cTnT, thereby preventing binding of the anti-cTnT antibody to skTnT, and b) determining the amount of cTnT; as well as to uses of said antibodies for determining the amount of cTnT, for preventing skTnT interference in determining the amount of cTnT, and/or for maintaining and/or improving specificity and diagnostic accuracy for a disease associated with cTnT.
The present invention refers, inter alia, to an antibody against skeletal Troponin T (skTnT), wherein the anti-skTnT antibody is not capable of binding to cardiac Troponin T (cTnT). The present invention also relates to uses of said antibodies for determining a skeletal muscle damage, methods of determining the amount of skTnT, wherein the method comprises contacting a sample with at least one of said antibodies, and determining the amount of skTnT. The invention further refers to corresponding polynucleotides encoding for and compositions comprising said antibody. The invention also relates to a computer-implemented method of determining an amount of skTnT using said antibody.
The invention relates to a sample tube holder (1) for a laboratory sample tube transport system (100), comprising: a radial inner support member (2) having a central opening (3), a radial outer support member (4) coaxially nesting the radial inner support member (2), a spring element (5), the spring element (5) comprising: a base portion (6) extending along a circumferential direction (C) and being coaxially nested in between the radial inner support member (2) and the radial outer support member (4), and finger portions (7) integrally protruding from the base portion (6) and being curved radially inwardly, the finger portions (7) being adapted to be elastically deflected radially outwardly by a sample tube (T) axially penetrating the central opening (3); and clamping pairs (8) distributed along the circumferential direction (C), the clamping pairs (8) respectively comprising a first clamping portion (9) for clamp-abutting the base portion (6) and a second clamping portion (10) for clamp-abutting the base portion (6) directly opposite said first clamping portion (9), the radial inner support member (2) comprising the first clamping portions (9) and the radial outer support member (4) comprising the second clamping portions (10).
The present invention provides antibodies specifically binding to Pepsinogen C and compositions and kits comprising such antibodies. Furthermore, provided are polynucleotides encoding such antibodies, host cells expressing said antibodies, methods of producing such antibodies and diagnostic methods using such antibodies.
A transdermal medical device (110) is proposed, specifically for sampling of capillary blood, comprising at least one stationary component (118) and at least one movable component (120). The movable component (120) is mounted to the stationary component (118) in a movable manner. The movable component (120) is movable from a distal position (154) to a proximal position (156). The movable component (120) comprises at least one penetration element (140) configured for penetrating the skin of a user. The penetration element (140), in the distal position (154) of the movable component (120), is received within the stationary component (118). In the proximal position (156) of the movable component (120), the penetration element (140) protrudes from an application side (168) of the stationary component (118). The movable component (120) further comprises at least one magnetic driver element (138) which is configured such that a movement of the movable component (120) is drivable by at least one external magnetic force. Further, a body mount (112) for attaching the transdermal medical device (110) to a body surface of a user, a transdermal medical kit (114) comprising the transdermal medical device (110) and the body mount (112), and a method of driving a penetration element (140) are proposed.
The present invention relates to a method for determining hemoglobin in a sample comprising red blood cells, said method comprising (a) dispensing a first aliquot of said sample on a first working area of a substrate; (b) providing a hemolyzed second aliquot of said sample and dispensing said second aliquot on a second working area; and (c) determining the hemoglobin in said first and second working area, wherein said method comprises a further step of contacting said first working area, but not the second working area, with a treatment solution. The present invention also relates to systems and diagnostic methods related to said method.
A test element (110) for detecting a fibrinogen level in a sample (112) of a bodily fluid is disclosed. The test element (110) comprises at least one substrate (114) and at least one capillary (116) for receiving and transporting the sample (112). The test element (110) further comprises at least one test region (118) and at least one control region (120) within the capillary (116), wherein the test element (110), in the test region (118), comprises at least two test electrodes (122), wherein the test element (110), in the control region (120), comprises at least two control electrodes (124). The test element (110) further comprises, in the test region (118), at least one detector compound (126), the detector compound (126) being capable of specifically cleaving fibrinogen.
The present invention concerns the field of point-of-care diagnostics. In particular, it relates to a method for determining fibrinogen in a sample comprising the steps of (a) contacting a fibrinogen binding agent, said fibrinogen binding agent comprising a first molecule which is capable of specifically binding fibrinogen and, reversibly bound to the said first molecule, a second molecule which is capable of specifically binding the first molecule, wherein the affinity of said second molecule for the first molecule is lower than the affinity of fibrinogen for said first molecule, with a sample suspected to comprise fibrinogen for a time and under conditions which allow for specific binding of fibrinogen to said first molecule, whereby the second molecule is released from said first molecule and fibrinogen is specifically bound by the first molecule, (b) determining said second molecule released from said first molecule, and (c) determining fibrinogen in the sample based on the released second molecule. The invention further contemplates a method for assessing coagulation defects or disorders in a subject as well as devices and kits for carrying out such methods.
The present invention relates to a method for determination or quantification of an analyte by mass spectrometry, a reagent kit, and a diagnostic system for performing the method.
A first aspect of the invention is directed to a detection zone of a lateral flow immunoassay device comprising a polyion multilayer, the polyion multilayer comprising (i) at least one layer comprising a complex of at least a first polyion and a first member of a binding pair; and (ii) at least one layer comprising a second polyion, which is oppositely charged with respect to the first polyion. In a second aspect, the invention relates to a lateral flow immunoassay device comprising a capillary channel, wherein the capillary channel houses (I) a detection zone as defined in the first aspect; (II) a first reagent zone, which comprises a labeled binding moiety; and (III) a second reagent zone, which comprises a binding moiety carrying a second member of a binding pair; wherein the binding moieties of (II) and of (III) are both capable of binding an analyte of interest, and the second member of a binding pair is capable of binding with the first member of a binding pair of the detection zone; wherein preferably first reagent zone of (II) and second reagent zone of (III) are spatially separated or overlap with each other at least partially. A third aspect of the invention is directed to the use of the lateral flow immunoassay device of the second aspect for determining an analyte in a sample. In a fourth aspect, the invention is related to a method for determining an analyte in a sample, the method comprising (a) contacting a sample with at least a labeled binding moiety and a binding moiety carrying a second member of a binding pair, thereby forming a mixture; (b) contacting the mixture formed in (a) with a polyion multilayer, the polyion multilayer comprising (i) at least one layer comprising a complex of at least a first polyion and a first member of a binding pair, (ii) at least one layer comprising a second polyion, thereby optionally forming complexes; (c) determining the amount of label containing complexes formed in (b); and (d) determining said analyte in a sample based on the result of step (c). A fifth aspect of the invention relates to a kit for determining an analyte in a sample, comprising the lateral flow immunoassay device of the second aspect and a pump, which is connected or connectable to the suction device.
A method for calibrating at least one analyte sensor for detecting at least one analyte in a sample is proposed. The analyte sensor comprises at least one measurement unit configured for generating at least two at least partially independent sensor signals. Each of the independent sensor signals is dependent on a concentration of the analyte. The method comprises the following steps: a) (110) measuring at least two at least partially independent sensor signals (112, 114) by using the measurement unit on at least one reference sample having a known analyte concentration; b) (116) determining a multidimensional calibration trajectory (118) by combining the measured at least two at least partially independent sensor signals (112, 114) by using at least one processing unit.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
36.
METHODS OF SELECTIVE DEPROTECTION AND SYNTHESIS OF TRANSHYDRINDANE- SKELETON-BASED COMPOUNDS
The present invention relates to methods of selectively deprotecting a transhydrindane-skeleton-based compound comprising at least two different silyl ether groups. The present invention further relates to methods of synthesizing a Vitamin D molecule and to Vitamin D molecules obtainable by such processes. Furthermore, the present invention relates to a compound according to formula (I) comprising two different silyl ether groups, its use in the synthesis of Vitamin D molecules and to methods of producing such a compound.
C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
The present invention relates to a method for coating a glass fiber fleece comprising contacting the surface of a glass fiber fleece with a hydrophilic copolymer; and crosslinking the copolymer. The invention further relates to a glass fiber filter, comprising a glass fiber fleece, wherein the surface of the glass fiber fleece is coated with a hydrophilic copolymer; and to a device for biomedical filter applications comprising the same.
A kit comprising an in-vitro diagnostic (IVD) consumable device in an environmentally sealed package, where after opening of the package usability of the IVD consumable device by an IVD analyzer is time-limited within an out-of-package usability time period. The package comprises a package mark, the reading of which triggers the start of the out-of-package usability time period, and the IVD consumable device comprises a consumable-device mark, linked to the package mark, the reading of which determines a time lapse since reading of the package mark and whether the time lapse is within or outside of the out-of-package usability time period. A respective IVD analyzer and a respective method of using the kit together with the IVD analyzer, are herein also disclosed.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
39.
IVD SYSTEM AND METHOD OF USING AN IVD CONSUMABLE DEVICE SUSCEPTIBLE TO ENVIRONMENTAL CONDITIONS
An IVD system comprising an IVD analyzer and an IVD consumable device configured to be used together with the IVD analyzer in order to carry out an IVD test that enables to obtain reliable test results by more reliably determining whether the IVD consumable device is within or outside of an out-of-package usability time period. In particular, the IVD analyzer comprises an optical detector for determining an optically detectable property of at least one indicator, at least one environmental sensor configured to determine a value of at least one environmental parameter affecting change of the optically detectable property over time and a controller configured to correlate the optically detected property of the at least one indicator to the determined value of the at least one environmental parameter by reference to a stored indicator-specific calibration of the optically detectable property obtained under varying values of the at least one environmental parameter.
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
G04F 13/00 - Apparatus for measuring unknown time intervals by means not provided for in groups
Fusion polypeptides are disclosed which are substrates for Kutzneria albida transglutaminase. The fusion polypeptides comprise one or more FKBP chaperone(s) and a target polypeptide. Each of these elements is separated from the neighboring element by a linker amino acid sequence. It was found that inserting glutamic acid containing transglutaminase recognition motifs into the linker amino acid chains is advantageous. Subsequent labeling reactions catalyzed by the transglutaminase surprisingly provide labeled fusion polypeptides have superior properties when compared with chemically random-labeled fusion polypeptides of similar design. Assays and kits are provided for in vitro detection of target antibodies in samples.
The invention relates to a calibration target (1) for calibrating an analytical device (20), wherein the calibration target (1) comprises an electrophoretic display (2) comprising first particles (P1) and second particles (P2), wherein the first particles (P1) and the second particles (P2) differ in at least one property, wherein the electrophoretic display (2) is controllable for displaying a calibration image (I) using the first particles (P1) and/or the second particles (P2).
G02F 1/167 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on translational movement of particles in a fluid under the influence of an applied field characterised by the electro-optical or magneto-optical effect by electrophoresis
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
A computer-implemented method for configuration management of at least one laboratory analyzer system (114) comprising at least one analytical unit (116) is proposed. The method comprises the following steps: a) retrieving at least one item of information on an analytical unit configuration of at least one analytical unit (116) of the laboratory analyzer system (114); b) applying at least one cryptographic function to the item of information on an analytical unit configuration thereby generating a secured item of information on an analytical unit configuration; c) providing the secured item of information on an analytical unit configuration to at least one database (122) of the laboratory analyzer system (114) and/or to at least one remote central database (118), wherein the remote central database (118) is at the manufacturer's site and/or a cloud database.
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Chemical reagents for use in genetic research; Chemical preparations for use in dna analysis [other than medical]; Biomolecule labelling kits comprising reagents for use in scientific research; Biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for use in medical genetic testing; Reagents for in-vitro laboratory use [for medical purposes]; Chemical preparations for use in dna analysis [medical]; Preparations for detecting genetic predispositions for medical purposes; Nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Laboratory devices for detecting genetic sequences; Diagnostic apparatus for research laboratory use; DNA microarray; Devices for analyzing genome information; Devices for analyzing protein sequence used as laboratory apparatus; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Nucleic acid sequencers for scientific purposes; Gene amplifiers; Computer software for use in medical decision support systems; Workflow management system software; Bioinformatics software. Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for DNA and RNA testing for medical purposes; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories; Genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; Laboratory research in the field of gene expression; Consultancy relating to laboratory testing; Medical research; Research and development in the field of diagnostic preparations; Providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; Information on the subject of scientific research in the field of biochemistry and biotechnology; Software as a service [SaaS].
44.
COMPOUNDS FOR STABILIZING PEPTIDES IN BIOLOGICAL SAMPLES
The present invention provides the use of a sulfone compound for stabilizing a peptide in a sample. Also provided is a corresponding method comprising adding a sulfone compound to a sample for stabilizing the peptide. Also provided is a vessel for collecting a sample comprising a peptide, wherein said vessel comprises a sulfone compound. Provided herein is further a composition comprising a peptide and a sulfone compound, a kit comprising a sulfone compound, a vessel of the invention or a composition of the invention. Finally, the present invention also relates to the use of a sulfone compound for inhibiting a protease.
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
45.
AN IVA TEST UNIT, A TEST SET COMPRISING THE IVA TEST UNIT AND A METHOD OF PRODUCING THE SAME
IVA test unit (1) comprising: a test strip (2) for detecting an analyte, wherein the test strip comprises at least an application function, a test reaction function and a test detection function; and a housing (3) for storing the test strip (2) wherein the housing (3) comprises an insert tray (4) and an insert hole (5) for inserting the test strip (2) into the insert tray (4), characterized in that the housing (3) is formed as one single piece.
An elution kit (1) for eluting a biological sample in a liquid (2) and dispensing the eluted sample liquid (2') onto a test element (102) of an analytical kit (101), the elution kit (1) comprises: a sample collection swab (3) for collecting the biological sample, wherein the sample collection swab (3) comprises a stick portion (4) for being hand-held and a deformable head portion (5) on the stick portion (4) for collecting the biological sample, wherein the head portion (5) is porous for the liquid (2); and an elution liquid tube (6) which comprises: an interior space (7) for housing the liquid (2), receiving the sample collection swab (3) and eluting the biological sample in the liquid (2); an insertion opening (10) on a first side of the interior space (7) for inserting the sample collection swab (3) into the interior space (7); a dispense opening (11) on a second side of the interior space (7) adjacent the first side for dispensing the eluted sample liquid; a first closure element (12) to seal the dispense opening (11) in a water-vapor impermeable manner; a second closure element (13) to seal the insertion opening (10) in a water-vapor impermeable manner, wherein the first closure element (12) and/or the second closure element (13) comprises a foil; and the liquid (2), wherein the elution liquid tube (6) contains the liquid (2), wherein the interior space (7) is defined by an inner surface (8) that comprises an elution zone (16) with at least one elution portion (9) having a smallest side-to-side distance y ranging between approximately 70% and 140% of a largest side-to-side distance x of the head portion (5) of the sample collection swab (3) and defining a gap (14) through which the sample collection swab (3) can be pushed and pulled in a closed state of the dispense opening (11).
09 - Scientific and electric apparatus and instruments
Goods & Services
Bio-sensors; Biochip sensors; Bar code readers; Bar code printers; Portable scanners; Radio-frequency identification (RFID) tags; Interfaces for computers; Electronic docking stations; Application software for cloud computing services; Bags adapted for laptops; Cases for tablet computers; Cases for data storage devices; Computer software relating to the medical field; Computer software for use in medical decision support systems; Workflow management system software; Software as a medical device [SaMD], downloadable; Application software for mobile devices.
A federated analytics (FA)/federated learning (FL) system configured to implement a federated learning pipeline or a federated analytics pipeline comprises: a centralized FA/FL platform comprising a client environment interface module; and a plurality of local environments, each local environment comprising a respective local memory configured to store local raw data and/or local pre-processed data. The local environments are configured to obtain data from data sources, and to generate local statistical models which are aggregated at the centralized platform to generate a global statistical model, thereby fulfilling a client request.
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
49.
THERMAL CONTROL DEVICE FOR TEMPERATURE CYCLING, METHOD FOR CONTROLLING TEMPERATURE CYCLING USING A THERMAL CONTROL DEVICE, AND SYSTEM FOR CONTROLLING TEMPERATURE OF A SAMPLE USING A THERMAL CONTROL DEVICE
In one embodiment, a thermal control device (110) adapted for temperature cycling is provided. The thermal control device (110) comprises a thermally conductive heat spreader layer (118) comprising a first side surface and a second side surface. A heater circuit (120) is disposed adjacent to and in thermal contact with at least one of the first side surface and the second side surface of the thermally conductive heat spreader layer (118). At least one thermal interface material layer (114) is disposed adjacent to and in thermal contact with one of the first side surface and the second side surface of the thermally conductive heat spreader layer (118). A cooling block (116) is disposed adjacent to and in thermal contact with the thermal interface material layer (114). The cooling block (116) is adapted to conduct heat energy away from the thermally conductive heat spreader layer (118). A controller is coupled to and adapted to control the heater circuit (120). In another embodiment, a diagnostic test device is provided.
The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing congestion in a subject comprising the steps of determining in a sample of the subject the amount of a BMP 10-type peptide (Bone Morphogenic Protein 10-type peptide) and comparing the amount of the BMP 10-type peptide to a reference for the BMP 10-type peptide, whereby congestion is to be assessed. The present invention also contemplates a method of differentiating between precapillary pulmonary hypertension and postcapillary pulmonary hypertension. Further, the invention concerns computer-implemented methods of the aforementioned methods as well as devices and kits for carrying out said methods. Yet, the invention in general relates to the use of a BMP 10-type peptide or a detection agent therefor in a sample of a subject for assessing congestion or the use of a BMP 10-type peptide or a detection agent therefor in a sample of a subject for differentiating between precapillary pulmonary hypertension and postcapillary pulmonary hypertension.
A computer-implemented training method (110) of training at least one trainable model is disclosed for classifying a patient's health condition into a systemic inflammatory state (168, 170, 172) selected from a predetermined group of at least three systemic inflammatory states (168, 170, 172). The method comprises: a. providing the trainable model; b. retrieving labeled training patient data, the training patient data comprising gene expression data of patients having known systemic inflammatory states (168, 170, 172); and c. training the trainable model on the labeled training patient data. Further disclosed is a computer-implemented classification method (112) of classifying a patient's health condition into a systemic inflammatory state (168, 170, 172) selected from a predetermined group of at least three systemic inflammatory states (168, 170, 172) and systems, computer programs and computer-readable storage media for performing the methods.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present invention relates to the field of diagnostics. In particular, it relates to a method for assessing systemic inflammation in a subject exhibiting symptoms thereof comprising a) determining in a sample of said subject the amounts of biomarkers from a group of biomarkers selected from i) a first group of biomarkers comprising: POMK, NEK6, KCNA5, LARGE2, ZNF425, NACA2, CFAP57, SPINT1, ZNF492, and S100A6, ii) a second group of biomarkers comprising: NEK6, SRPK3, TNFSF8, S100A6, NMUR1, DHFR, HIST1H4D, ZDHHC4, TRAF3, and SGMSlor iii) a third group of biomarkers comprising: C9orfl35, ZNF425, ACOT4, SPDYA, DAPP1, LY86, ZPBP2, RPL3L, UPK1B, and APBB3, b) comparing said determined amounts of biomarkers from said group of biomarkers to a reference, and c) assessing systemic inflammation in the subject. Further, the present invention, in general, relates to the use of the amounts of said biomarkers in a sample of a subject exhibiting symptoms of systemic inflammation for assessing systemic inflammation. Moreover, contemplated are a device and a kit for assessing systemic inflammation.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
The invention relates to a laboratory device (1) for handling laboratory sample container racks (50), the laboratory device (1) comprising a base (2) extending horizontally, the base (2) being adapted to support laboratory sample container racks (50) placed thereon, a first finger (3) being movable relative to the base (2), the first finger (3) being adapted to position a laboratory sample container rack (50) on the base (2), a second finger (4) being adapted to horizontally counteract the first finger (3) so that the laboratory sample container rack (50) positioned on the base (2) is holdable in between the first finger (3) and the second finger (4), a down-holder (5) being movable relative to the base (2), the down-holder (5) being adapted to releasably vertically secure the laboratory sample container rack (50) positioned on the base (2), and a linkage (6) which motion-couples the first finger (3) and the second finger (4) and the down-holder (5) to one another.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
A transfer method and a transfer device (110) for transferring at least one volume of a cell suspension from a first sample tube (112) to a second sample tube (114) are disclosed. The transfer device (110) comprises: - at least one first cannula (116) configured for transferring the at least one volume of the cell suspension from the first sample tube (112) to the second sample tube (114), wherein the first cannula (116) comprises at least one first cannula tip (118) configured for at least partially penetrating into an interior (120) of the first sample tube (112), wherein the first cannula (116) further comprises at least one second cannula tip (122) configured for at least partially penetrating into an interior (124) of the second sample tube (114), wherein the first cannula tip (118) and the second cannula tip (122) are in direct fluidic connection (126) with each other, enabling a transfer of the at least one volume of the cell suspension from the first sample tube (112) to the second sample tube (114); and - at least one second cannula (130) configured for providing at least one pressure port (132) to the interior (120) of the first sample tube (112).
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical preparations for scientific purposes, other than for medical or veterinary use; Biological preparations, other than for medical or veterinary purposes; Biochemical preparations for scientific purposes; Diagnostic reagents for scientific or research use; Reagents for use in scientific apparatus for chemical or biological analysis; Chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; Nucleic acids for scientific purposes; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Chemical reagents for use in genetic research.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; diagnostic preparations for
research laboratory use; diagnostic reagents for scientific
or research use; biochemicals, namely, monoclonal antibodies
for in vitro scientific or research use; diagnostic reagents
for in vitro use in biochemistry, clinical chemistry and
microbiology; calibration fluids for medical apparatus;
testing kit comprising reagents for conducting enzyme-linked
immunosorbent assays (elisa) [other than for medical or
veterinary purposes].
There is disclosed a method and sensor for detecting a plurality of analytes in bodily fluid, the sensor comprising electrodes including a first working electrode, a second working electrode, a third working electrode, a counter electrode, and a reference electrode; wherein the first working electrode is configured to detect a first signal indicative of a first analyte concentration using potentiometry; wherein the second working electrode is configured to detect a second signal indicative of a second analyte concentration using amperometry; wherein the third working electrode is configured to detect a third signal indicative of a third analyte concentration using amperometry; wherein the first analyte, the second analyte, and third analyte are different analytes; wherein the first signal, the second signal, and the third signal are detected using the same reference electrode; wherein at least part of the detection of the first signal occurs simultaneously with the detection of the second signal; wherein the second signal and third signal are detected using the same counter electrode; wherein at least part of the detection of the second signal occurs simultaneously with the detection of the third signal; and wherein at least one of the second working electrode and third working electrode is continuously polarized by application of a polarization voltage during detection of the first signal, second signal and third signal.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means
G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
G01N 33/487 - Physical analysis of biological material of liquid biological material
A61B 5/1495 - Calibrating or testing in vivo probes
G01N 33/62 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving urea
G01N 33/64 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving ketones
G01N 33/98 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving alcohol, e.g. ethanol in breath
58.
METHOD OF CONTROLLING THE FUNCTIONALITY OF AN ANALYTICAL SYSTEM
A method of controlling the functionality of an analytical system (110) is disclosed. The method comprises: a. providing at least one container (114) containing at least one control fluid, the container (114) comprising at least one identifier (124), wherein the identifier (124) comprises at least one identification number of the container (114); b. reading the identifier (124) of the container (114) by using at least one reading device (113) of the analytical system (110); and c. performing a database query in a database (116) of the analytical system (110), the database (116) containing database entries (130) for a plurality of known containers (114) comprising identification numbers of the known containers (114) and assigned expiry information for the respective known containers (114), the database query comprising checking if the container (114) already has a database entry (130) in the data- base (116). Further, an analytical system (110) comprising at least one analytical device (112) for determining an analyte concentration in a sample of a bodily fluid is disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
There is disclosed an electrode for an electrochemical immunoassay; wherein the electrode is functionalized with at least one antibody or fragment thereof configured to bind to at least one analyte; and wherein the at least one antibody or fragment thereof is conjugated with at least one redox species such that the electrochemical activity of the at least one redox species is altered when the at least one antibody or fragment thereof binds to the at least one analyte.
The present invention relates to methods of assessing heart failure (HF), determining the risk of developing HF, monitoring HF, classifying HF, risk stratification and prognosis in patients with HF and determining the therapeutic effect of a treatment regimen for HF in a subject by determining the level of one or more cardiac related (poly)peptide biomarkers in the interstitial fluid (ISF) from the subject, and comparing the determined level to a reference value. Further this invention refers to the use of ISF in the methods described herein.
The present invention relates to methods of diagnosing whether a subject has endometriosis, uterine/pelvic pathology and/or endometriosis and/or uterine/pelvic pathology associated neuropathic pain, to methods of determining the therapeutic effect of a treatment regimen for endometriosis, uterine/pelvic pathology and/or endometriosis and/or uterine/pelvic pathology associated neuropathic pain, and methods of monitoring endometriosis, uterine/pelvic pathology and/or endometriosis and/or uterine/pelvic pathology associated neuropathic pain progression in a subject, by determining the amount or concentration of EphA1 in a sample of the subject, and comparing the determined level to a reference value.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present invention relates to monoclonal antibodies, or fragments thereof, which bind to MYBPC3 (Myosin binding protein C, cardiac type). Further, the present invention relates to a kit comprising the monoclonal antibodies of the present invention. In some embodiments, the kit is provided as sandwich assay. Further the present invention relates to the in vitro use of the monoclonal antibodies, or fragments thereof, or of the kit of the present invention for the detection of MYBPC3 in a sample. Moreover, the present invention relates to diagnostic methods, such as the assessment of cardiac condition, for example of myocardial infarction.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The invention relates to a single-use dispenser (1) for supplying a control liquid (L) to an analytical device, the single-use dispenser (1) comprising a blow-molded vessel (2) fluid-tightly delimiting an interior volume (3), and a volume (4) of the control liquid (L), wherein the volume (4) of the control liquid (L) is stored within the interior volume (3), and wherein the blow-molded vessel (2) has a predetermined breaking point (5) adapted to form an outlet aperture (8) for the control liquid (L) by breaking the blow-molded vessel (2) in its predetermined breaking point (5).
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; diagnostic reagents for
scientific or research use; chemicals for use in performing
nucleic acid polymerase chain reactions [other than medical
and veterinary]; diagnostic reagents for in vitro use in
biochemistry, clinical chemistry and microbiology research;
reagents in kit form for conducting enzyme-linked
immunosorbent assays (elisa) [other than for medical or
veterinary purposes]; nucleic acid amplification reagents
[other than for medical use]. In vitro diagnostic preparations for medical use; diagnostic
reagents for medical use; reagents for in-vitro laboratory
use [for medical purposes]; chemical preparations for use in
DNA analysis [medical]; nucleic acid sequences for medical
and veterinary purposes. Scientific apparatus and instruments; laboratory instruments
[other than for medical use]; electric instruments for use
in the diagnosis of blood [laboratory apparatus];
quantitative polymerase chain reaction [PCR] instruments for
scientific use; real-time polymerase chain reaction [PCR]
instruments for scientific use; diagnostic apparatus for
research laboratory use; DNA microarray; devices for
analyzing protein sequence used as laboratory apparatus;
research laboratory analyzers for measuring, testing and
analyzing blood and other bodily fluids; computer software
for use in medical decision support systems; workflow
management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus
for medical purposes used in medical laboratories; real-time
polymerase chain reaction [PCR] instruments for medical use;
diagnostic testing instruments for use in immunoassay
procedure [medical]; immunochemical medical diagnostic
testing apparatus for detecting and measuring antibody
levels; apparatus for DNA and RNA testing for medical
purposes; analysing apparatus for medical purposes.
The present invention provides a screening method for obtaining an antibody composition comprising at least two different monoclonal antibodies. The invention also relates to said antibody composition, and its use. Further, the invention provides a kit comprising said antibody composition. The invention also provides a method for determining a level of antibodies directed to an antigen in a sample.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
66.
METHODS FOR DETERMINING MS REAGENT PARAMETERS VIA LEACHABLE COMPOUNDS
The present invention relates to a method for determining a mass spectrometry (MS) reagent stored in a storage container for a period of time and/or at least one storage parameter thereof, said method comprising (a) determining at least one leachable compound of said storage container; (b) comparing the at least one leachable compound determined in step (a) to a reference, and (c) determining said MS reagent and/or at least one storage parameter thereof based on the comparing in step (b); The present invention also relates to a method of quality assurance of an MS analysis, to a data carrier, an MS system, and a kit related thereto.
The present invention relates to antibodies and antigen-binding fragments thereof, in particular (ds)Fv fragments. The invention also relates to methods of producing these antibodies and fragments thereof as well as their uses and corresponding polynucleotides and kits comprising the same.
Methods of evaluating mRNA or cDNA are provided. Instead of evaluating the mRNA or cDNA as a whole, multiple distinct portions of the mRNA or cDNA (such as different exons or untranslated regions) are separately quantified. The separate quantities are then evaluated by a trained classifier, which converts the separate quantities to a composite score indicative of the expression level of the mRNA or corresponding cDNA.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; testing kit comprising reagents for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes].
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for medical purposes; biological
preparations for medical purposes; biochemical preparations
for medical use; in vitro diagnostic preparations for
medical use; diagnostic reagents for medical use; reagents
for in-vitro laboratory use [for medical purposes];
diagnostic biomarker reagents for medical purposes. Scientific apparatus and instruments; laboratory instruments
[other than for medical use]; instruments for diagnosis [for
scientific use]; quantitative polymerase chain reaction
[PCR] instruments for scientific use; real-time polymerase
chain reaction [PCR] instruments for scientific use;
diagnostic apparatus for research laboratory use; research
laboratory analyzers for measuring, testing and analyzing
blood and other bodily fluids, laboratory instrument for the
detection of pathogens and toxins in a biological sample for
research use. Medical apparatus and instruments; testing apparatus for
medical purposes; diagnostic apparatus for medical purposes;
real-time polymerase chain reaction [PCR] instruments for
medical use; diagnostic testing instruments for use in
immunoassay procedure [medical]; immunochemical medical
diagnostic testing apparatus for detecting and measuring
antibody levels; apparatus for analyzing substances [for
medical use]; diagnostic apparatus for medical purposes used
in medical laboratories.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for medical purposes; biological
preparations for medical purposes; biochemical preparations
for medical use; in vitro diagnostic preparations for
medical use; diagnostic reagents for medical use; reagents
for in-vitro laboratory use [for medical purposes];
diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; testing apparatus for
medical purposes; diagnostic apparatus for medical purposes;
real-time polymerase chain reaction [PCR] instruments for
medical use; diagnostic testing instruments for use in
immunoassay procedure [medical]; immunochemical medical
diagnostic testing apparatus for detecting and measuring
antibody levels; apparatus for analysing substances [for
medical use]; diagnostic apparatus for medical purposes used
in medical laboratories.
72.
MEDICAL SYSTEM AND A METHOD FOR MONITORING THE STORAGE CONDITIONS THEREOF
A medical system (110) and a method for monitoring the storage conditions of at least one medical system (110) are disclosed. The medical system (110) comprises: - at least one analyte sensor (112) for detecting at least one analyte in a bodily fluid, the analyte sensor (112) being configured for at least partial transcutaneous insertion into a body tissue (114) of a user (116); and - at least one disabling device (118) operably connected to the analyte sensor (112), the disabling device (118) comprising at least one monitoring element (120), the monitoring element (120) being configured for undergoing a change in at least one mechanical property when storage conditions of the analyte sensor (112) are outside a specification range, the mechanical property change being configured such that the transcutaneous insertion of the analyte sensor (112) into the body tissue (114) is irreversibly prevented.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; diagnostic reagents for
scientific or research use; chemicals for use in performing
nucleic acid polymerase chain reactions [other than medical
and veterinary]; diagnostic reagents for in vitro use in
biochemistry, clinical chemistry and microbiology research;
reagents in kit form for conducting enzyme-linked
immunosorbent assays (elisa) [other than for medical or
veterinary purposes]; nucleic acid amplification reagents
[other than for medical use]. In vitro diagnostic preparations for medical use; diagnostic
reagents for medical use; reagents for in-vitro laboratory
use [for medical purposes]; chemical preparations for use in
DNA analysis [medical]; nucleic acid sequences for medical
and veterinary purposes. Scientific apparatus and instruments; laboratory instruments
[other than for medical use]; electric instruments for use
in the diagnosis of blood [laboratory apparatus];
quantitative polymerase chain reaction [PCR] instruments for
scientific use; real-time polymerase chain reaction [PCR]
instruments for scientific use; diagnostic apparatus for
research laboratory use; DNA microarray; devices for
analyzing protein sequence used as laboratory apparatus;
research laboratory analyzers for measuring, testing and
analyzing blood and other bodily fluids; computer software
for use in medical decision support systems; workflow
management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus
for medical purposes used in medical laboratories; real-time
polymerase chain reaction [PCR] instruments for medical use;
diagnostic testing instruments for use in immunoassay
procedure [medical]; immunochemical medical diagnostic
testing apparatus for detecting and measuring antibody
levels; apparatus for DNA and RNA testing for medical
purposes; analysing apparatus for medical purposes.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; diagnostic preparations for
research laboratory use; diagnostic reagents for scientific
or research use; chemical reagents for use in genetic
research; chemical preparations for use in DNA analysis
[other than medical]; biomolecule labeling kits comprising
reagents for use in scientific research; biochemicals,
namely, monoclonal antibodies for in vitro scientific or
research use; diagnostic reagents for in vitro use in
biochemistry, clinical chemistry and microbiology research;
calibration fluids for medical apparatus; reagents in kit
form for conducting enzyme-linked immunosorbent assays
(elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; diagnostic
reagents for medical use; reagents for use in medical
genetic testing; reagents for in-vitro laboratory use [for
medical purposes]; chemical preparations for use in DNA
analysis [medical]; preparations for detecting genetic
predispositions for medical purposes; nucleic acid sequences
for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments
[other than for medical use]; instruments for diagnosis [for
scientific use]; quantitative polymerase chain reaction
[PCR] instruments for scientific use; real-time polymerase
chain reaction [PCR] instruments for scientific use;
laboratory devices for detecting genetic sequences;
diagnostic apparatus for research laboratory use; DNA
microarray; devices for analyzing genome information;
devices for analyzing protein sequence used as laboratory
apparatus; research laboratory analyzers for measuring,
testing and analyzing blood and other bodily fluids; nucleic
acid sequencers for scientific purposes; laboratory devices
for detecting genetic sequences; gene amplifiers; computer
software for use in medical decision support systems;
workflow management system software; bioinformatics
software. Testing apparatus for medical purposes; diagnostic apparatus
for medical purposes; real-time polymerase chain reaction
[PCR] instruments for medical use; diagnostic testing
instruments for use in immunoassay procedure [medical];
immunochemical medical diagnostic testing apparatus for
detecting and measuring antibody levels; apparatus for DNA
and RNA testing for medical purposes; apparatus for
analysing substances [for medical use]; diagnostic apparatus
for medical purposes used in medical laboratories; genetic
testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for
scientific research purposes; laboratory research in the
field of gene expression; consultancy relating to laboratory
testing; medical research; research and development in the
field of diagnostic preparations; providing temporary use of
on-line non-downloadable operating software for accessing
and using a cloud computing network; information on the
subject of scientific research in the field of biochemistry
and biotechnology; software as a service [SaaS].
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; diagnostic preparations for
research laboratory use; diagnostic reagents for scientific
or research use; chemical reagents for use in genetic
research; chemical preparations for use in DNA analysis
[other than medical]; biomolecule labeling kits comprising
reagents for use in scientific research; biochemicals,
namely, monoclonal antibodies for in vitro scientific or
research use; diagnostic reagents for in vitro use in
biochemistry, clinical chemistry and microbiology research;
calibration fluids for medical apparatus; reagents in kit
form for conducting enzyme-linked immunosorbent assays
(elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; diagnostic
reagents for medical use; reagents for use in medical
genetic testing; reagents for in-vitro laboratory use [for
medical purposes]; chemical preparations for use in DNA
analysis [medical]; preparations for detecting genetic
predispositions for medical purposes; nucleic acid sequences
for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments
[other than for medical use]; instruments for diagnosis [for
scientific use]; quantitative polymerase chain reaction
[PCR] instruments for scientific use; real-time polymerase
chain reaction [PCR] instruments for scientific use;
laboratory devices for detecting genetic sequences;
diagnostic apparatus for research laboratory use; DNA
microarray; devices for analyzing genome information;
devices for analyzing protein sequence used as laboratory
apparatus; research laboratory analyzers for measuring,
testing and analyzing blood and other bodily fluids; nucleic
acid sequencers for scientific purposes; laboratory devices
for detecting genetic sequences; gene amplifiers; computer
software for use in medical decision support systems;
workflow management system software; bioinformatics
software. Testing apparatus for medical purposes; diagnostic apparatus
for medical purposes; real-time polymerase chain reaction
[PCR] instruments for medical use; diagnostic testing
instruments for use in immunoassay procedure [medical];
immunochemical medical diagnostic testing apparatus for
detecting and measuring antibody levels; apparatus for DNA
and RNA testing for medical purposes; apparatus for
analysing substances [for medical use]; diagnostic apparatus
for medical purposes used in medical laboratories; genetic
testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for
scientific research purposes; laboratory research in the
field of gene expression; consultancy relating to laboratory
testing; medical research; research and development in the
field of diagnostic preparations; providing temporary use of
on-line non-downloadable operating software for accessing
and using a cloud computing network; information on the
subject of scientific research in the field of biochemistry
and biotechnology; software as a service [SaaS].
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; diagnostic preparations for
research laboratory use; diagnostic reagents for scientific
or research use; chemical reagents for use in genetic
research; chemical preparations for use in DNA analysis
[other than medical]; biomolecule labeling kits comprising
reagents for use in scientific research; biochemicals,
namely, monoclonal antibodies for in vitro scientific or
research use; diagnostic reagents for in vitro use in
biochemistry, clinical chemistry and microbiology research;
calibration fluids for medical apparatus; reagents in kit
form for conducting enzyme-linked immunosorbent assays
(elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; diagnostic
reagents for medical use; reagents for use in medical
genetic testing; reagents for in-vitro laboratory use [for
medical purposes]; chemical preparations for use in DNA
analysis [medical]; preparations for detecting genetic
predispositions for medical purposes; nucleic acid sequences
for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments
[other than for medical use]; instruments for diagnosis [for
scientific use]; quantitative polymerase chain reaction
[PCR] instruments for scientific use; real-time polymerase
chain reaction [PCR] instruments for scientific use;
laboratory devices for detecting genetic sequences;
diagnostic apparatus for research laboratory use; DNA
microarray; devices for analyzing genome information;
devices for analyzing protein sequence used as laboratory
apparatus; research laboratory analyzers for measuring,
testing and analyzing blood and other bodily fluids; nucleic
acid sequencers for scientific purposes; laboratory devices
for detecting genetic sequences; gene amplifiers; computer
software for use in medical decision support systems;
workflow management system software; bioinformatics
software. Testing apparatus for medical purposes; diagnostic apparatus
for medical purposes; real-time polymerase chain reaction
[PCR] instruments for medical use; diagnostic testing
instruments for use in immunoassay procedure [medical];
immunochemical medical diagnostic testing apparatus for
detecting and measuring antibody levels; apparatus for DNA
and RNA testing for medical purposes; apparatus for
analysing substances [for medical use]; diagnostic apparatus
for medical purposes used in medical laboratories; genetic
testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for
scientific research purposes; laboratory research in the
field of gene expression; consultancy relating to laboratory
testing; medical research; research and development in the
field of diagnostic preparations; providing temporary use of
on-line non-downloadable operating software for accessing
and using a cloud computing network; information on the
subject of scientific research in the field of biochemistry
and biotechnology; software as a service [SaaS].
77.
ACCELERATED MARKING OF 5-FORMYL CYTOSINE AND USE IN NUCLEIC ACID METHYLATION SEQUENCING
Disclosed herein are compositions for use in preparing target nucleic acid molecules including one or more 5-formyl cytosine bases or adducts of 5-formyl cytosine. Also disclosed herein are methods of efficiently synthesizing nucleic acid molecules including one or more 5-formyl cytosine bases from target nucleic acid molecules which include one or more 5-hydroxymethyl cytosine bases. The present disclosure also provides for methods of detecting epigenetic modifications in a target nucleic acid molecule, such as those epigenetic modifications characterized by methylation of cytosine at the 5-position position (e.g., 5-methyl cytosine; 5-hydroxymethyl cytosine).
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for medical purposes; biological
preparations for medical purposes; biochemical preparations
for medical use; in vitro diagnostic preparations for
medical use; diagnostic reagents for medical use; reagents
for in-vitro laboratory use [for medical purposes];
diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; testing apparatus for
medical purposes; diagnostic apparatus for medical purposes;
real-time polymerase chain reaction [PCR] instruments for
medical use; diagnostic testing instruments for use in
immunoassay procedure [medical]; immunochemical medical
diagnostic testing apparatus for detecting and measuring
antibody levels; apparatus for analysing substances [for
medical use]; diagnostic apparatus for medical purposes used
in medical laboratories.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for medical purposes; biological
preparations for medical purposes; biochemical preparations
for medical use; in vitro diagnostic preparations for
medical use; diagnostic reagents for medical use; reagents
for in-vitro laboratory use [for medical purposes];
diagnostic biomarker reagents for medical purposes. Scientific apparatus and instruments; laboratory instruments
[other than for medical use]; instruments for diagnosis [for
scientific use]; quantitative polymerase chain reaction
[PCR] instruments for scientific use; real-time polymerase
chain reaction [PCR] instruments for scientific use;
diagnostic apparatus for research laboratory use; research
laboratory analyzers for measuring, testing and analyzing
blood and other bodily fluids; laboratory instrument for the
detection of pathogens and toxins in a biological sample for
research use. Medical apparatus and instruments; testing apparatus for
medical purposes; diagnostic apparatus for medical purposes;
real-time polymerase chain reaction [PCR] instruments for
medical use; diagnostic testing instruments for use in
immunoassay procedure [medical]; immunochemical medical
diagnostic testing apparatus for detecting and measuring
antibody levels; apparatus for analysing substances [for
medical use]; diagnostic apparatus for medical purposes used
in medical laboratories.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for medical purposes; biological
preparations for medical purposes; biochemical preparations
for medical use; in vitro diagnostic preparations for
medical use; diagnostic reagents for medical use; reagents
for in-vitro laboratory use [for medical purposes];
diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; testing apparatus for
medical purposes; diagnostic apparatus for medical purposes;
real-time polymerase chain reaction [PCR] instruments for
medical use; diagnostic testing instruments for use in
immunoassay procedure [medical]; immunochemical medical
diagnostic testing apparatus for detecting and measuring
antibody levels; apparatus for analysing substances [for
medical use]; diagnostic apparatus for medical purposes used
in medical laboratories.
81.
COMPUTER IMPLEMENTED METHOD FOR QUALITY ASSURANCE OF AN IN VITRO-DIAGNOSTIC ANALYZER
A computer implemented method for quality assurance of an in vitro-diagnostic analyzer (121) is proposed. The method comprising a) (110) retrieving at least one recall message (116) comprising information about an identity of a recalled item of the analyzer (121); b) (112) processing the recall message (116) by determining if the recalled item is onboard the analyzer (121); c) (114) applying, in case the recalled item is determined to be onboard the analyzer (121), at least one quality assurance action on the analyzer (121).
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
82.
MODULAR RACK LIFTING EQUIPMENT AND RACK LIFTING SYSTEM
characterised incharacterised in having: a lifting unit including a basket loadable with a rack for holding sample containers and a drive mechanism for lifting and lowering the basket; a conveyor unit including a conveyor portion for conveying racks in a horizontal direction and a traverser for moving the racks loaded into the basket to the conveyor portion; and a support body for supporting the lifting unit and the conveyor unit. A plurality of said modules can be linked together.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
B65G 47/57 - Devices for transferring articles or materials between conveyors, i.e. discharging or feeding devices to or from inclined or vertical conveyor sections for articles
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes.
(2) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.
The present invention relates to a method for determining an analyte in a mass spectrometry (MS) device comprising a first and a second mass filter, said method comprising (i) filtering for an analyte ion species in the first mass filter; (ii) optionally fragmenting at least a fraction of ions obtained by the filtering in step (i) in a collision cell, wherein the collision energy of said fragmenting is selected to be lower than a predetermined collision energy causing fragmentation of said analyte ion species; (iii) filtering for said analyte ion species filtered for in step (i) in the second mass filter, and (iv) detecting said analyte ion species filtered for in step (iii), thereby determining said analyte. Moreover, the present invention relates to devices, systems, and uses related to said method.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes.
(2) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids, laboratory instrument for the detection of pathogens and toxins in a biological sample for research use.
(3) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analyzing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes.
(2) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; laboratory instrument for the detection of pathogens and toxins in a biological sample for research use.
(3) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes.
(2) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.
88.
METHOD OF MANUFACTURING A PLURALITY OF ANALYTICAL TEST ELEMENTS
A method and a manufacturing device (110) for manufacturing a plurality of diagnostic, test elements (112) comprising at least one core strip (114) and at least one support foil strip (116). The method may be used for manufacturing a plurality of analytical test elements for lateral flow assays used in the field of medical diagnostics for detecting one or more properties of a sample of a bodily fluid, e.g. a presence and/or a concentration of at least one analyte in the sample of the bodily fluid. Other fields of application of the present invention, however, are also feasible.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes.
(2) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.
90.
MODIFIED TRIBLOCK COPOLYMER COMPOUNDS AND METHODS OF USE THEREOF
This application discloses triblock copolymers (TBC) molecules with modified chemical headgroup moieties. The triblock copolymers are poly(2-methyl-2-oxazoline)-poly(dimethylsiloxane)-poly(2-methyl-2-oxazoline) (PMOXA-PDMS-PMOXA) copolymers. The headgroup moieties comprise azide or triazole. The TBC molecules are useful as components in polymersome, vesicle, and membrane compositions, such as synthetic membranes used in nanopore sequencing devices. The application also discloses methods of preparing the modified TBC molecules and methods of use.
This application discloses hybrid lipid bilayer compositions that include a phospholipid, a triblock copolymer, and a molecule with a pore connecting the two sides of the bilayer, and the use of these lipid bilayer compositions in electrochemical cells for nanopore-based nucleic acid detection techniques, such as nanopore Sequencing-by-Expansion (Nano-SBX) and nanopore Sequencing-by-Synthesis (Nano-SBS) methods.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes].
(2) In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes.
(3) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software.
(4) Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. (1) Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes].
(2) In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes.
(3) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software.
(4) Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. (1) Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes].
(2) In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes.
(3) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software.
(4) Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. (1) Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].
95.
TRANSITIVE AND COMMUTATIVE MULTIMODAL MODELS AND USES
Computer-implemented methods for analysing multimodal data are described. A computer-implemented method comprises generating an output data set by processing an input data set comprising data from one or more of a set of at least three modalities, using a machine learning model comprising a transitive and commutative machine-learning model. Related methods, products and systems are described.
The present invention is directed to a handheld device for the detection of electrostatic discharge, comprising an evaluation unit, and a cable antenna (1,1') made of coaxial cable, wherein the cable antenna is formed in a coil-like manner with a number n of windings (2, 2'), with n >_ 2, each winding (2, 2') being wound around a winding axis, a diameter of each winding is less than 30 cm, and the windings of the cable antenna are spaced apart from each other, preferably by means of at least one spacer.
The present invention relates to an in vitro method for cultivating one or more antibody expressing cell(s). The method comprises cultivating one or more antibody expressing cell(s) obtained from peripheral blood in the presence of IL-2, IL-21 and a non-cell surface presented CD40-stimulating agent and in the absence of feeder cells. Moreover, herein provided are methods for producing antibodies comprising the step of cultivating one or more antibody expressing cell(s) according to the method of the invention, a novel CD40-stimulating agent and uses therefrom as well as a cell culture medium.
Provided are DNA library preparation methods and compositions that duplicate a target nucleic acid sequence. A target DNA template including the target sequence is circularized via an end adapter to form a circular construct, which is bidirectionally extended by a polymerase-mediated extension that is initiated at nick sites of the end adapter. Following polymerase-mediated extension, a double-length DNA template is formed that includes two copies of the target DNA template (and hence two copies of the target sequence). Each strand of the double-length DNA template includes a parental polynucleotide strand joined to a newly synthesized daughter strand copy of the parental polynucleotide strand. Predetermined sequences can be included in the double-length DNA template, such a primer sequences, unique molecule identifiers, and sequence indexes. Sequencing of the double-length DNA template can reveal genetic/epigenetic information associated with the target sequence. Also provided are methods to create asymmetric and multi-length DNA template constructs.
Provided are lipid binding molecules and/or combinations of the lipid binding protein with a lipid component (i.e., a mispid) that are used to modify the interaction of a target molecule with a lipid membrane. This includes use of the lipid binding molecules and/or mispids, for example, to improve sequencing efficiency and throughput of nanopore-based sequencing systems. To sequence a target molecule, such as a nucleic acid sequence or a surrogate nucleic acid polymer derived therefrom, lipid binding molecules and/or mispids thereof are combined with the target molecule. The mixture is then applied to a nanopore-based sequencing chip. The target molecule is then sequenced in the presence of the lipid binding molecules and/or nanodiscs, thereby improving the capture, arrival time, and effective concentration of the target molecule across the membrane of the chip. Such improved efficiency is particularly beneficial, for example, when concentrations of a target molecule are low.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays other than for medical or veterinary purposes
