Abstract

A federated analytics (FA)/federated learning (FL) system configured to implement a federated learning pipeline or a federated analytics pipeline comprises: a centralized FA/FL platform comprising a client environment interface module; and a plurality of local environments, each local environment comprising a respective local memory configured to store local raw data and/or local pre-processed data. The local environments are configured to obtain data from data sources, and to generate local statistical models which are aggregated at the centralized platform to generate a global statistical model, thereby fulfilling a client request.

IPC Classes  ?

• G06N 20/00 - Machine learning
• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

Abstract

In one embodiment, a thermal control device (110) adapted for temperature cycling is provided. The thermal control device (110) comprises a thermally conductive heat spreader layer (118) comprising a first side surface and a second side surface. A heater circuit (120) is disposed adjacent to and in thermal contact with at least one of the first side surface and the second side surface of the thermally conductive heat spreader layer (118). At least one thermal interface material layer (114) is disposed adjacent to and in thermal contact with one of the first side surface and the second side surface of the thermally conductive heat spreader layer (118). A cooling block (116) is disposed adjacent to and in thermal contact with the thermal interface material layer (114). The cooling block (116) is adapted to conduct heat energy away from the thermally conductive heat spreader layer (118). A controller is coupled to and adapted to control the heater circuit (120). In another embodiment, a diagnostic test device is provided.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatusHeat insulating devices

Abstract

The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing congestion in a subject comprising the steps of determining in a sample of the subject the amount of a BMP 10-type peptide (Bone Morphogenic Protein 10-type peptide) and comparing the amount of the BMP 10-type peptide to a reference for the BMP 10-type peptide, whereby congestion is to be assessed. The present invention also contemplates a method of differentiating between precapillary pulmonary hypertension and postcapillary pulmonary hypertension. Further, the invention concerns computer-implemented methods of the aforementioned methods as well as devices and kits for carrying out said methods. Yet, the invention in general relates to the use of a BMP 10-type peptide or a detection agent therefor in a sample of a subject for assessing congestion or the use of a BMP 10-type peptide or a detection agent therefor in a sample of a subject for differentiating between precapillary pulmonary hypertension and postcapillary pulmonary hypertension.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A computer-implemented training method (110) of training at least one trainable model is disclosed for classifying a patient's health condition into a systemic inflammatory state (168, 170, 172) selected from a predetermined group of at least three systemic inflammatory states (168, 170, 172). The method comprises: a. providing the trainable model; b. retrieving labeled training patient data, the training patient data comprising gene expression data of patients having known systemic inflammatory states (168, 170, 172); and c. training the trainable model on the labeled training patient data. Further disclosed is a computer-implemented classification method (112) of classifying a patient's health condition into a systemic inflammatory state (168, 170, 172) selected from a predetermined group of at least three systemic inflammatory states (168, 170, 172) and systems, computer programs and computer-readable storage media for performing the methods.

IPC Classes  ?

• G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
• G16B 40/20 - Supervised data analysis
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention relates to the field of diagnostics. In particular, it relates to a method for assessing systemic inflammation in a subject exhibiting symptoms thereof comprising a) determining in a sample of said subject the amounts of biomarkers from a group of biomarkers selected from i) a first group of biomarkers comprising: POMK, NEK6, KCNA5, LARGE2, ZNF425, NACA2, CFAP57, SPINT1, ZNF492, and S100A6, ii) a second group of biomarkers comprising: NEK6, SRPK3, TNFSF8, S100A6, NMUR1, DHFR, HIST1H4D, ZDHHC4, TRAF3, and SGMSlor iii) a third group of biomarkers comprising: C9orfl35, ZNF425, ACOT4, SPDYA, DAPP1, LY86, ZPBP2, RPL3L, UPK1B, and APBB3, b) comparing said determined amounts of biomarkers from said group of biomarkers to a reference, and c) assessing systemic inflammation in the subject. Further, the present invention, in general, relates to the use of the amounts of said biomarkers in a sample of a subject exhibiting symptoms of systemic inflammation for assessing systemic inflammation. Moreover, contemplated are a device and a kit for assessing systemic inflammation.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention relates to a laboratory device (1) for handling laboratory sample container racks (50), the laboratory device (1) comprising a base (2) extending horizontally, the base (2) being adapted to support laboratory sample container racks (50) placed thereon, a first finger (3) being movable relative to the base (2), the first finger (3) being adapted to position a laboratory sample container rack (50) on the base (2), a second finger (4) being adapted to horizontally counteract the first finger (3) so that the laboratory sample container rack (50) positioned on the base (2) is holdable in between the first finger (3) and the second finger (4), a down-holder (5) being movable relative to the base (2), the down-holder (5) being adapted to releasably vertically secure the laboratory sample container rack (50) positioned on the base (2), and a linkage (6) which motion-couples the first finger (3) and the second finger (4) and the down-holder (5) to one another.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• B01L 9/06 - Test-tube standsTest-tube holders
• B65G 65/00 - Loading or unloading
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G01N 35/04 - Details of the conveyor system

Abstract

A transfer method and a transfer device (110) for transferring at least one volume of a cell suspension from a first sample tube (112) to a second sample tube (114) are disclosed. The transfer device (110) comprises: - at least one first cannula (116) configured for transferring the at least one volume of the cell suspension from the first sample tube (112) to the second sample tube (114), wherein the first cannula (116) comprises at least one first cannula tip (118) configured for at least partially penetrating into an interior (120) of the first sample tube (112), wherein the first cannula (116) further comprises at least one second cannula tip (122) configured for at least partially penetrating into an interior (124) of the second sample tube (114), wherein the first cannula tip (118) and the second cannula tip (122) are in direct fluidic connection (126) with each other, enabling a transfer of the at least one volume of the cell suspension from the first sample tube (112) to the second sample tube (114); and - at least one second cannula (130) configured for providing at least one pressure port (132) to the interior (120) of the first sample tube (112).

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Biological preparations, other than for medical or veterinary purposes; Biochemical preparations for scientific purposes; Diagnostic reagents for scientific or research use; Reagents for use in scientific apparatus for chemical or biological analysis; Chemical substances for analyses in laboratories, other than for medical or veterinary purposes; Nucleic acids for scientific purposes; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Chemical reagents for use in genetic research.

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; testing kit comprising reagents for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes].

Abstract

There is disclosed a method and sensor for detecting a plurality of analytes in bodily fluid, the sensor comprising electrodes including a first working electrode, a second working electrode, a third working electrode, a counter electrode, and a reference electrode; wherein the first working electrode is configured to detect a first signal indicative of a first analyte concentration using potentiometry; wherein the second working electrode is configured to detect a second signal indicative of a second analyte concentration using amperometry; wherein the third working electrode is configured to detect a third signal indicative of a third analyte concentration using amperometry; wherein the first analyte, the second analyte, and third analyte are different analytes; wherein the first signal, the second signal, and the third signal are detected using the same reference electrode; wherein at least part of the detection of the first signal occurs simultaneously with the detection of the second signal; wherein the second signal and third signal are detected using the same counter electrode; wherein at least part of the detection of the second signal occurs simultaneously with the detection of the third signal; and wherein at least one of the second working electrode and third working electrode is continuously polarized by application of a polarization voltage during detection of the first signal, second signal and third signal.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means
• G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• A61B 5/1495 - Calibrating or testing in vivo probes
• G01N 33/62 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving urea
• G01N 33/64 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving ketones
• G01N 33/98 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving alcohol, e.g. ethanol in breath

Abstract

A method of controlling the functionality of an analytical system (110) is disclosed. The method comprises: a. providing at least one container (114) containing at least one control fluid, the container (114) comprising at least one identifier (124), wherein the identifier (124) comprises at least one identification number of the container (114); b. reading the identifier (124) of the container (114) by using at least one reading device (113) of the analytical system (110); and c. performing a database query in a database (116) of the analytical system (110), the database (116) containing database entries (130) for a plurality of known containers (114) comprising identification numbers of the known containers (114) and assigned expiry information for the respective known containers (114), the database query comprising checking if the container (114) already has a database entry (130) in the data- base (116). Further, an analytical system (110) comprising at least one analytical device (112) for determining an analyte concentration in a sample of a bodily fluid is disclosed.

IPC Classes  ?

• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

There is disclosed an electrode for an electrochemical immunoassay; wherein the electrode is functionalized with at least one antibody or fragment thereof configured to bind to at least one analyte; and wherein the at least one antibody or fragment thereof is conjugated with at least one redox species such that the electrochemical activity of the at least one redox species is altered when the at least one antibody or fragment thereof binds to the at least one analyte.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention relates to methods of assessing heart failure (HF), determining the risk of developing HF, monitoring HF, classifying HF, risk stratification and prognosis in patients with HF and determining the therapeutic effect of a treatment regimen for HF in a subject by determining the level of one or more cardiac related (poly)peptide biomarkers in the interstitial fluid (ISF) from the subject, and comparing the determined level to a reference value. Further this invention refers to the use of ISF in the methods described herein.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to methods of diagnosing whether a subject has endometriosis, uterine/pelvic pathology and/or endometriosis and/or uterine/pelvic pathology associated neuropathic pain, to methods of determining the therapeutic effect of a treatment regimen for endometriosis, uterine/pelvic pathology and/or endometriosis and/or uterine/pelvic pathology associated neuropathic pain, and methods of monitoring endometriosis, uterine/pelvic pathology and/or endometriosis and/or uterine/pelvic pathology associated neuropathic pain progression in a subject, by determining the amount or concentration of EphA1 in a sample of the subject, and comparing the determined level to a reference value.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention relates to monoclonal antibodies, or fragments thereof, which bind to MYBPC3 (Myosin binding protein C, cardiac type). Further, the present invention relates to a kit comprising the monoclonal antibodies of the present invention. In some embodiments, the kit is provided as sandwich assay. Further the present invention relates to the in vitro use of the monoclonal antibodies, or fragments thereof, or of the kit of the present invention for the detection of MYBPC3 in a sample. Moreover, the present invention relates to diagnostic methods, such as the assessment of cardiac condition, for example of myocardial infarction.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/577 - ImmunoassayBiospecific binding assayMaterials therefor involving monoclonal antibodies
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• G01N 33/534 - Production of labelled immunochemicals with radioactive label
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a single-use dispenser (1) for supplying a control liquid (L) to an analytical device, the single-use dispenser (1) comprising a blow-molded vessel (2) fluid-tightly delimiting an interior volume (3), and a volume (4) of the control liquid (L), wherein the volume (4) of the control liquid (L) is stored within the interior volume (3), and wherein the blow-molded vessel (2) has a predetermined breaking point (5) adapted to form an outlet aperture (8) for the control liquid (L) by breaking the blow-molded vessel (2) in its predetermined breaking point (5).

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• A61J 1/06 - Ampoules or cartridges
• B65D 1/09 - Ampoules

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic reagents for scientific or research use; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; nucleic acid amplification reagents [other than for medical use]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; electric instruments for use in the diagnosis of blood [laboratory apparatus]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes used in medical laboratories; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; analysing apparatus for medical purposes.

Abstract

The present invention provides a screening method for obtaining an antibody composition comprising at least two different monoclonal antibodies. The invention also relates to said antibody composition, and its use. Further, the invention provides a kit comprising said antibody composition. The invention also provides a method for determining a level of antibodies directed to an antigen in a sample.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard

Abstract

The present invention relates to a method for determining a mass spectrometry (MS) reagent stored in a storage container for a period of time and/or at least one storage parameter thereof, said method comprising (a) determining at least one leachable compound of said storage container; (b) comparing the at least one leachable compound determined in step (a) to a reference, and (c) determining said MS reagent and/or at least one storage parameter thereof based on the comparing in step (b); The present invention also relates to a method of quality assurance of an MS analysis, to a data carrier, an MS system, and a kit related thereto.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 30/06 - Preparation

Abstract

The present invention relates to antibodies and antigen-binding fragments thereof, in particular (ds)Fv fragments. The invention also relates to methods of producing these antibodies and fragments thereof as well as their uses and corresponding polynucleotides and kits comprising the same.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 16/26 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones

Abstract

Methods of evaluating mRNA or cDNA are provided. Instead of evaluating the mRNA or cDNA as a whole, multiple distinct portions of the mRNA or cDNA (such as different exons or untranslated regions) are separately quantified. The separate quantities are then evaluated by a trained classifier, which converts the separate quantities to a composite score indicative of the expression level of the mRNA or corresponding cDNA.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Goods & Services

(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; testing kit comprising reagents for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes].

Goods & Services

Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids, laboratory instrument for the detection of pathogens and toxins in a biological sample for research use. Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analyzing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Abstract

A medical system (110) and a method for monitoring the storage conditions of at least one medical system (110) are disclosed. The medical system (110) comprises: - at least one analyte sensor (112) for detecting at least one analyte in a bodily fluid, the analyte sensor (112) being configured for at least partial transcutaneous insertion into a body tissue (114) of a user (116); and - at least one disabling device (118) operably connected to the analyte sensor (112), the disabling device (118) comprising at least one monitoring element (120), the monitoring element (120) being configured for undergoing a change in at least one mechanical property when storage conditions of the analyte sensor (112) are outside a specification range, the mechanical property change being configured such that the transcutaneous insertion of the analyte sensor (112) into the body tissue (114) is irreversibly prevented.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/1495 - Calibrating or testing in vivo probes

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic reagents for scientific or research use; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; nucleic acid amplification reagents [other than for medical use]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; electric instruments for use in the diagnosis of blood [laboratory apparatus]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes used in medical laboratories; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; analysing apparatus for medical purposes.

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].

Abstract

Disclosed herein are compositions for use in preparing target nucleic acid molecules including one or more 5-formyl cytosine bases or adducts of 5-formyl cytosine. Also disclosed herein are methods of efficiently synthesizing nucleic acid molecules including one or more 5-formyl cytosine bases from target nucleic acid molecules which include one or more 5-hydroxymethyl cytosine bases. The present disclosure also provides for methods of detecting epigenetic modifications in a target nucleic acid molecule, such as those epigenetic modifications characterized by methylation of cytosine at the 5-position position (e.g., 5-methyl cytosine; 5-hydroxymethyl cytosine).

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Goods & Services

Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; laboratory instrument for the detection of pathogens and toxins in a biological sample for research use. Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Abstract

A computer implemented method for quality assurance of an in vitro-diagnostic analyzer (121) is proposed. The method comprising a) (110) retrieving at least one recall message (116) comprising information about an identity of a recalled item of the analyzer (121); b) (112) processing the recall message (116) by determining if the recalled item is onboard the analyzer (121); c) (114) applying, in case the recalled item is determined to be onboard the analyzer (121), at least one quality assurance action on the analyzer (121).

IPC Classes  ?

• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices

Abstract

characterised incharacterised in having: a lifting unit including a basket loadable with a rack for holding sample containers and a drive mechanism for lifting and lowering the basket; a conveyor unit including a conveyor portion for conveying racks in a horizontal direction and a traverser for moving the racks loaded into the basket to the conveyor portion; and a support body for supporting the lifting unit and the conveyor unit. A plurality of said modules can be linked together.

IPC Classes  ?

• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G01N 35/04 - Details of the conveyor system
• B65G 47/57 - Devices for transferring articles or materials between conveyors, i.e. discharging or feeding devices to or from inclined or vertical conveyor sections for articles
• B65G 47/64 - Switching conveyors

Goods & Services

(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. (2) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Abstract

The present invention relates to a method for determining an analyte in a mass spectrometry (MS) device comprising a first and a second mass filter, said method comprising (i) filtering for an analyte ion species in the first mass filter; (ii) optionally fragmenting at least a fraction of ions obtained by the filtering in step (i) in a collision cell, wherein the collision energy of said fragmenting is selected to be lower than a predetermined collision energy causing fragmentation of said analyte ion species; (iii) filtering for said analyte ion species filtered for in step (i) in the second mass filter, and (iv) detecting said analyte ion species filtered for in step (iii), thereby determining said analyte. Moreover, the present invention relates to devices, systems, and uses related to said method.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes

Goods & Services

(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. (2) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids, laboratory instrument for the detection of pathogens and toxins in a biological sample for research use. (3) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analyzing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. (2) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; laboratory instrument for the detection of pathogens and toxins in a biological sample for research use. (3) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. (2) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Abstract

A method and a manufacturing device (110) for manufacturing a plurality of diagnostic, test elements (112) comprising at least one core strip (114) and at least one support foil strip (116). The method may be used for manufacturing a plurality of analytical test elements for lateral flow assays used in the field of medical diagnostics for detecting one or more properties of a sample of a bodily fluid, e.g. a presence and/or a concentration of at least one analyte in the sample of the bodily fluid. Other fields of application of the present invention, however, are also feasible.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding

Goods & Services

(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. (2) Medical apparatus and instruments; testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories.

Abstract

This application discloses triblock copolymers (TBC) molecules with modified chemical headgroup moieties. The triblock copolymers are poly(2-methyl-2-oxazoline)-poly(dimethylsiloxane)-poly(2-methyl-2-oxazoline) (PMOXA-PDMS-PMOXA) copolymers. The headgroup moieties comprise azide or triazole. The TBC molecules are useful as components in polymersome, vesicle, and membrane compositions, such as synthetic membranes used in nanopore sequencing devices. The application also discloses methods of preparing the modified TBC molecules and methods of use.

IPC Classes  ?

• C08G 73/02 - Polyamines
• A61K 8/14 - Liposomes
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• C08G 77/452 - Block- or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences

Abstract

This application discloses hybrid lipid bilayer compositions that include a phospholipid, a triblock copolymer, and a molecule with a pore connecting the two sides of the bilayer, and the use of these lipid bilayer compositions in electrochemical cells for nanopore-based nucleic acid detection techniques, such as nanopore Sequencing-by-Expansion (Nano-SBX) and nanopore Sequencing-by-Synthesis (Nano-SBS) methods.

IPC Classes  ?

• B01D 71/74 - Natural macromolecular material or derivatives thereof
• B01D 71/80 - Block polymers
• B01D 71/58 - Other polymers having nitrogen in the main chain, with or without oxygen or carbon only
• B01D 71/70 - Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only

Goods & Services

(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. (2) In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes. (3) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. (4) Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. (1) Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].

Goods & Services

(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. (2) In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes. (3) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. (4) Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. (1) Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].

Goods & Services

(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. (2) In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes. (3) Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. (4) Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. (1) Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].

Abstract

Computer-implemented methods for analysing multimodal data are described. A computer-implemented method comprises generating an output data set by processing an input data set comprising data from one or more of a set of at least three modalities, using a machine learning model comprising a transitive and commutative machine-learning model. Related methods, products and systems are described.

IPC Classes  ?

• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks
• G06N 3/048 - Activation functions
• G06N 3/0895 - Weakly supervised learning, e.g. semi-supervised or self-supervised learning
• G06N 3/096 - Transfer learning
• G06N 3/0475 - Generative networks
• G06N 3/09 - Supervised learning
• G06N 3/044 - Recurrent networks, e.g. Hopfield networks
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The present invention is directed to a handheld device for the detection of electrostatic discharge, comprising an evaluation unit, and a cable antenna (1,1') made of coaxial cable, wherein the cable antenna is formed in a coil-like manner with a number n of windings (2, 2'), with n >_ 2, each winding (2, 2') being wound around a winding axis, a diameter of each winding is less than 30 cm, and the windings of the cable antenna are spaced apart from each other, preferably by means of at least one spacer.

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics
• G01R 29/12 - Measuring electrostatic fields
• H01Q 1/14 - SupportsMounting means for wire or other non-rigid radiating elements
• H01Q 1/27 - Adaptation for use in or on movable bodies

Abstract

The present invention relates to an in vitro method for cultivating one or more antibody expressing cell(s). The method comprises cultivating one or more antibody expressing cell(s) obtained from peripheral blood in the presence of IL-2, IL-21 and a non-cell surface presented CD40-stimulating agent and in the absence of feeder cells. Moreover, herein provided are methods for producing antibodies comprising the step of cultivating one or more antibody expressing cell(s) according to the method of the invention, a novel CD40-stimulating agent and uses therefrom as well as a cell culture medium.

IPC Classes  ?

• C12N 5/0781 - B cellsProgenitors thereof

Abstract

Provided are DNA library preparation methods and compositions that duplicate a target nucleic acid sequence. A target DNA template including the target sequence is circularized via an end adapter to form a circular construct, which is bidirectionally extended by a polymerase-mediated extension that is initiated at nick sites of the end adapter. Following polymerase-mediated extension, a double-length DNA template is formed that includes two copies of the target DNA template (and hence two copies of the target sequence). Each strand of the double-length DNA template includes a parental polynucleotide strand joined to a newly synthesized daughter strand copy of the parental polynucleotide strand. Predetermined sequences can be included in the double-length DNA template, such a primer sequences, unique molecule identifiers, and sequence indexes. Sequencing of the double-length DNA template can reveal genetic/epigenetic information associated with the target sequence. Also provided are methods to create asymmetric and multi-length DNA template constructs.

IPC Classes  ?

• C12Q 1/6855 - Ligating adaptors

Abstract

Provided are lipid binding molecules and/or combinations of the lipid binding protein with a lipid component (i.e., a mispid) that are used to modify the interaction of a target molecule with a lipid membrane. This includes use of the lipid binding molecules and/or mispids, for example, to improve sequencing efficiency and throughput of nanopore-based sequencing systems. To sequence a target molecule, such as a nucleic acid sequence or a surrogate nucleic acid polymer derived therefrom, lipid binding molecules and/or mispids thereof are combined with the target molecule. The mixture is then applied to a nanopore-based sequencing chip. The target molecule is then sequenced in the presence of the lipid binding molecules and/or nanodiscs, thereby improving the capture, arrival time, and effective concentration of the target molecule across the membrane of the chip. Such improved efficiency is particularly beneficial, for example, when concentrations of a target molecule are low.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays other than for medical or veterinary purposes

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic reagents for scientific or research use; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; nucleic acid amplification reagents [other than for medical use]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; electric instruments for use in the diagnosis of blood [laboratory apparatus]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes used in medical laboratories; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; analysing apparatus for medical purposes.

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic reagents for scientific or research use; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology research; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; nucleic acid amplification reagents [other than for medical use]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; electric instruments for use in the diagnosis of blood [laboratory apparatus]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes used in medical laboratories; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; analysing apparatus for medical purposes.

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes].

Abstract

Systems and methods of executing a machine learning model on a specialized computing device can comprise obtaining raw input data by a first computing device; obtaining the machine learning model including a function that applies a set of M model parameters to at least one channel of the raw input data; determining a configuration parameter K for the specialized computing device; configuring the raw input data based on the configuration parameter to obtain configured input data; configuring the machine learning model based on the configuration parameter to obtain a configured machine learning model with a configured model dimension corresponding to the data size of the acceleration path; executing the configured machine learning model with the configured model parameter using the configured input data to obtain output data; and providing the output data.

IPC Classes  ?

• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06F 17/15 - Correlation function computation
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Goods & Services

Downloadable software for use in healthcare information management and analysis, namely, for capturing, storing, aggregating, viewing, analyzing, disseminating, retrieving and sharing medical images, medical data, medical test results, diagnostic data, slides and specimens, in the fields of healthcare, medical research and clinical research Providing temporary use of non-downloadable software for use in healthcare information management and analysis, namely, for capturing, storing, aggregating, viewing, analyzing, disseminating, retrieving and sharing medical images, medical data, medical test results, diagnostic data, slides and specimens, in the fields of healthcare, medical research and clinical research

Abstract

Classification of cell types A computer-implemented method of classifying cell types comprises: receiving image data representing a digital test image, the digital test image depicting a cell; applying a classifier model to the received image data, the classifier model configured to output a cell type of the cell depicted in the digital test image, wherein: the classifier model has been trained using training data comprising a plurality of digital records, each digital record comprising: training image data representing a digital training image depicting a cell; and a label indicative of the cell type of the cell depicted in the digital training image; and determining one or more digital reference images which depict cells most similar to the cell depicted in the digital test image; generating instructions which, when executed by a display component of a computing device, cause the display component to display: the cell type output by the classifier model; and the determined one or more digital reference images which depict cells most similar to the cell depicted in the digital test image. A corresponding diagnostic support and similar computer-implemented methods are also provided.

IPC Classes  ?

• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/778 - Active pattern-learning, e.g. online learning of image or video features
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06F 18/21 - Design or setup of recognition systems or techniquesExtraction of features in feature spaceBlind source separation
• G06F 18/40 - Software arrangements specially adapted for pattern recognition, e.g. user interfaces or toolboxes therefor
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/091 - Active learning
• G06T 7/00 - Image analysis

Abstract

StreptococcusStreptococcus agalactiaeermBermTRermTlsaClsaElsaE by a multiplex real-time PCR assay.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Goods & Services

Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]. Medical apparatus and instruments; diagnostic apparatus for medical purposes; apparatus for carrying-out diagnostic tests for medical purposes; testing apparatus for medical purposes.

Goods & Services

Reagents for use in scientific apparatus for chemical or biological analysis; biochemicals namely, polypeptides for in vitro research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; reagents for in-vitro laboratory use [other than for medical or veterinary purposes]; chemical reagents for use in genetic research; chemical preparations for use in dna analysis [other than medical]. In vitro diagnostic preparations for medical use; biochemical preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in dna analysis [medical].

Abstract

The present invention relates to a method for assessing chronic liver disease in a subject, said method comprising (a) determining an amount of the biomarker Insulin-like growth factor-binding protein 3 (IGFBP3) in a sample from said subject; (b) determining an amount of the biomarker gamma-glutamyltransferase (GGT) in said sample; (c) comparing the amounts of the biomarkers determined in steps (a) and (b) to references for said biomarkers and/or calculating a score for assessing chronic liver disease; and (d) assessing chronic liver disease in said subject based on the comparison and/or the calculation made in step (c). The present invention further relates to computer-implemented methods, databases, devices, and uses related thereto.

IPC Classes  ?

• C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

CandidaCandidaCandida species.

IPC Classes  ?

• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

A container storage device (1) comprises: a buffer (21) on which a rack (23) capable of accommodating a first container (22) and a second container (22) is placed; a transfer mechanism (3) for placing the containers in the rack (23); and a control unit (101). The control unit (101) includes a receiving unit (102) for receiving a dispensing instruction for the first container (22) and the second container (22) from an analysis device (11), and performs control to: place the first container (22) in the rack (23) on the basis of the received dispensing instruction for the first container (22); check whether a certain period of time has elapsed since the receiving unit (102) received the dispensing instruction for the first container (22); if the dispensing instruction for the second container (22) is received before the certain period of time has elapsed, additionally place the second container (22) in the rack (23) at the timing at which the dispensing instruction for the second container (22) was received, and dispense the rack (23), in which the first container (22) and the second container (22) have been placed, to the analysis device (11); and if the dispensing instruction for the second container (22) has not been received even when the certain period of time has elapsed, dispense the rack (23), in which the first container (22) has been placed, to the analysis device (11).

IPC Classes  ?

• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G01N 35/04 - Details of the conveyor system

Abstract

The invention relates to an apparatus (1) for measuring a filling level of a sample container via laser transmission detection, the apparatus (1) comprising a laser source arrangement (2) for emitting light (L) of two distinctive wavelengths (A, B), a fiber optic (3) for guiding the light (L) emitted by the laser source arrangement (2), the fiber optic (3) extending from a first fiber portion (3) to a second fiber portion (5), the latter of which having a fiber ending (6) directed onto a target position (T) of the apparatus (1), such that a beam path (P) for light (L) leaving the fiber ending (6) is spanned toward the target position (T), a sample holder (7) for holding the sample container within the beam path (P), and a light transmission detector (D) for detecting light (L) reaching the target position (T) along the beam path (P), the light (L) reaching the target position (T) being transmitted by the sample container and/or a content thereof when placed within the beam path (P).

IPC Classes  ?

• G01F 23/292 - Light
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 15/05 - Investigating sedimentation of particle suspensions in blood
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands

Abstract

The present invention relates to a method of detecting the effect induced by a sodium-glucose cotransporter inhibitor (SGLTi ) in a subject suffering from a cardiovascular disease, the method comprising a) determining the amount of Fatty Acid Binding Protein 3 (FABP3) in a sample of the subject treated with SGLTi; and b) comparing the amount of said FABP3 to a reference amountAlso encompassed are computer-implemented methods, computer program products, devices and kits for carrying out the method of the present invention. The present invention further relates to the use of FABP3, the use of FABP3 and a cardiac injury marker, and/or the use of a detection agent of FABP3 or FABP3 and a cardiac injury marker for detecting the effect induced by a sodium-glucose cotransporter inhibitor (SGLTi) in a subject suffering from a cardiovascular disease.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Goods & Services

Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic biomarker reagents for medical purposes. Medical apparatus and instruments; Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic biomarker reagents for medical purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Diagnostic apparatus for research laboratory use; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Laboratory instrument for the detection of pathogens and toxins in a biological sample for research use. Medical apparatus and instruments; Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

Chemical, biological and biochemical preparations for the analysis of biological samples for medical purposes; medical diagnostic assays and reagents for the analysis of biological samples for clinical or medical purposes; diagnostic reagents and preparations for medical purposes; in vitro diagnostic agents for the analysis of biological samples for medical purposes; all of the foregoing excluding active pharmaceutical ingredients, isotopes and radioisotopes Analyzers for the analysis of biological samples for medical diagnostic purposes

Goods & Services

Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic biomarker reagents for medical purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Diagnostic apparatus for research laboratory use; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Laboratory instrument for the detection of pathogens and toxins in a biological sample for research use. Medical apparatus and instruments; Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories.

Goods & Services

(1) Reagents for use in scientific apparatus for chemical or biological analysis; biochemicals namely, polypeptides for in vitro research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; reagents for in-vitro laboratory use [other than for medical or veterinary purposes]; chemical reagents for use in genetic research; chemical preparations for use in dna analysis [other than medical]. (2) In vitro diagnostic preparations for medical use; biochemical preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in dna analysis [medical].

Goods & Services

(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]. (2) Medical apparatus and instruments; diagnostic apparatus for medical purposes; apparatus for carrying-out diagnostic tests for medical purposes; testing apparatus for medical purposes.

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Chemical reagents for use in genetic research; Chemical preparations for use in dna analysis [other than medical]; Biomolecule labelling kits comprising reagents for use in scientific research; Biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for use in medical genetic testing; Reagents for in-vitro laboratory use [for medical purposes]; Chemical preparations for use in dna analysis [medical]; Preparations for detecting genetic predispositions for medical purposes; Nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Laboratory devices for detecting genetic sequences; Diagnostic apparatus for research laboratory use; DNA microarray; Devices for analyzing genome information; Devices for analyzing protein sequence used as laboratory apparatus; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Nucleic acid sequencers for scientific purposes; Gene amplifiers; Computer software for use in medical decision support systems; Workflow management system software; Bioinformatics software. Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for DNA and RNA testing for medical purposes; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories; Genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; Laboratory research in the field of gene expression; Consultancy relating to laboratory testing; Medical research; Research and development in the field of diagnostic preparations; Providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; Information on the subject of scientific research in the field of biochemistry and biotechnology; Software as a service [SaaS].

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Chemical reagents for use in genetic research; Chemical preparations for use in dna analysis [other than medical]; Biomolecule labelling kits comprising reagents for use in scientific research; Biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for use in medical genetic testing; Reagents for in-vitro laboratory use [for medical purposes]; Chemical preparations for use in dna analysis [medical]; Preparations for detecting genetic predispositions for medical purposes; Nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Laboratory devices for detecting genetic sequences; Diagnostic apparatus for research laboratory use; DNA microarray; Devices for analyzing genome information; Devices for analyzing protein sequence used as laboratory apparatus; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Nucleic acid sequencers for scientific purposes; Gene amplifiers; Computer software for use in medical decision support systems; Workflow management system software; Bioinformatics software. Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for DNA and RNA testing for medical purposes; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories; Genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; Laboratory research in the field of gene expression; Consultancy relating to laboratory testing; Medical research; Research and development in the field of diagnostic preparations; Providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; Information on the subject of scientific research in the field of biochemistry and biotechnology; Software as a service [SaaS].

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Chemical reagents for use in genetic research; Chemical preparations for use in dna analysis [other than medical]; Biomolecule labelling kits comprising reagents for use in scientific research; Biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for use in medical genetic testing; Reagents for in-vitro laboratory use [for medical purposes]; Chemical preparations for use in dna analysis [medical]; Preparations for detecting genetic predispositions for medical purposes; Nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Laboratory devices for detecting genetic sequences; Diagnostic apparatus for research laboratory use; DNA microarray; Devices for analyzing genome information; Devices for analyzing protein sequence used as laboratory apparatus; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Nucleic acid sequencers for scientific purposes; Gene amplifiers; Computer software for use in medical decision support systems; Workflow management system software; Bioinformatics software. Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for DNA and RNA testing for medical purposes; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes used in medical laboratories; Genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; Laboratory research in the field of gene expression; Consultancy relating to laboratory testing; Medical research; Research and development in the field of diagnostic preparations; Providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; Information on the subject of scientific research in the field of biochemistry and biotechnology; Software as a service [SaaS].

Abstract

Described are methods of detecting modified nucleotide bases in a DNA sample using specific DNA glycosylases to excise a modified nucleobase of interest. Prior to glycosylase treatment, DNA target fragments are copied by a DNA polymerase to produce a complementary copy strand that preserves the genetic information of the DNA target strand. Following glycosylase treatment, the DNA target fragments are repaired by either ligating across the gaps to produce a deletion at each position of the modified nucleobase of interest or filling in the gaps with a single non-native nucleotide to produce a base substitution at each position of the modified nucleobase of interest. Comparison of the DNA sequences of the two strands of the target fragments enables identification of the positions of the modified nucleotide base in the DNA target fragment.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present invention relates to compositions and methods to detect the Acinetobacter calcoaceticus- Acinetobacter baumannii complex species and to identify the most prevalent carbapenemases found in carbapenem resistant Acinetobacter calcoaceticus-baumannii (CRAB) such as blaOXA-23-like, blaOXA-24-like, blaOXA-58-like and blaNDM-like by a multiplex real-time PCR assay.

IPC Classes  ?

• C12Q 1/6851 - Quantitative amplification
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

The present invention provides compositions and methods relating to novel digital PCR (dPCR) assay designs (droplet digital or other systems) for the detection and quantitation of multiple hepatitis B virus (HBV) gene targets. The compositions and method can further include non-extendible blocker oligonucleotides for reduction of non-specific inter-amplicon extension.

IPC Classes  ?

• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

Goods & Services

Chemical and biochemical reagents for use in the field of life science and for rna and dna testing; reagents, preparations and test kits for laboratory analysis of nucleic acids for scientific or clinical purposes; reagents, preparations and test kits for determining cancer for clinical or research use Medical test kits comprising reagents for testing body fluids to determine cell or nucleic acid abnormities or to determine pre-malignant and malignant conditions; chemical reagents, diagnostic preparations and test kits for nucleic acid analysis for medical use; kits consisting primarily of reagents for nucleic acid detection and analysis

Abstract

This automated analysis device comprises a first analyzing unit for performing analysis related to a first analysis item group, a second analyzing unit for performing analysis of a second analysis item group using a measuring principle different from the first analyzing unit, a reagent storage unit for storing at least one first reagent vessel accommodating a reagent used for the analysis by the first analyzing unit and at least one second reagent vessel for accommodating a reagent used for the analysis by the second analyzing unit, an agitating unit for agitating a solution in the second reagent vessel, and a control unit for controlling operation of the agitating unit, wherein the control unit controls the operation of the agitating unit to agitate a solution in the first reagent vessel. This makes it possible to agitate a plurality of reagents used for a plurality of measurements that employ different principles, while suppressing an increase in the size of the device.

IPC Classes  ?

• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

A first aspect of the invention is related to the use of a (poly)label for generating a quantifiable signal for an analyte of interest in mass spectrometry, wherein the (poly)label has the structure (I). In a second aspect, the invention is directed to a process for modifying an analyte of interest for obtaining an increased intensity signal in mass spectrometry. A third aspect of the invention is directed to a method for determining an analyte of interest by mass spectrometry. A fourth aspect of the invention relates to a (poly)label having structure of formula (Ia). In a fifth aspect, the invention is related to a reaction product comprising a polypeptide and a (poly)label having the general structure (III).

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a solid phase peptide synthesis (SPPS) solvent system and use thereof. The present invention further relates to a solid phase peptide synthesis (SPPS), a kit, a peptide synthesizer and the use thereof.

IPC Classes  ?

• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

A method for automated microscopic scanning is disclosed. The method comprises the following steps: a. (110) image data acquisition, wherein the image data acquisition comprises generating microscopic images of a sample by scanning at least one pre-defined scanning area of at least one microscopic slide (128)carrying the sample by using at least one image scanner (122); b. (112) determining at least one feature characterizing at least one biological entity of the sample by applying at least one classification algorithm to the microscopic images by using at least one processing device, wherein the feature is compared to at least one pre-defined criterion, wherein the determining and the comparing is performed in parallel to the image data acquisition, wherein the image data acquisition of said microscopic slide (128) is discontinued by at least one controlling device of the image scanner (122) as soon as the determined feature reaches the pre- defined criterion; and c. repeating the method for a next microscopic slide (128).

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

A system, a method, and a user interface are described for customizing external quality control testing for a diagnostic system. Quality control assays must be run for each assay panel capable of being run on a diagnostic instrument. Each quality control assay for each assay panel is given a desired frequency and a desired rotation. A QC rule customization module allows a user to create, manage, delete, or view QC rules. Reminders can be sent for upcoming quality control assays that are due. Alerts are sent if the quality control assays are missed.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Abstract

The system and method for processing a digital pathology image using a machine learning model that includes a self-supervised hierarchical Vision Transformer (ViT) configured to perform unsupervised clustering with multiple classification tokens. The method includes receiving a digital pathology image that depicts a tissue slice stained with histological dyes. The digital pathology image may be processed to generate a result comprising multiple predicted classifications of individual patches of the digital pathology image. The result is generated by a machine-learning model using a self-supervised hierarchical Vision Transformer (ViT) that may further comprise a multi-head self-attention module configured to predict a crosspatch relevance metric using an attention mechanism for each individual patch in the digital pathology image thereby assigning the individual patches to a cluster based on the crosspatch relevance metrics.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

The present disclosure refers to a method for operating an in-vitro-diagnostics laboratory system, IVD laboratory system. The IVD laboratory system has a housing (12) with an opening (12a); an actuator device (10), arranged in the housing (12), for processing sample containers; a cover (11) configured to cover the opening (12a); a cooling device (14) configured to cool the sample containers; and a cooling device control unit (15) configured to control operation of the cooling device (14). The method comprises: determining whether the cover (11) is open; determining whether the cooling device control unit (15) is active; in a normal system mode, disabling operation of the actuator device (10) based on at least one of the cover (11) being open and the cooling device control unit (15) being inactive; and in a bypass system mode, enabling operation of the actuator device (10) based on the cover (11) being open and the cooling device control unit (15) being active.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms

Abstract

The invention relates to a method of operating a gripping device (100) being adapted to insert sample containers (1) into sample container racks (2) and/or remove sample containers (1) from sample container racks (2), wherein the gripping device (100) comprises gripping fingers (3) being adapted to grip the sample containers (1), wherein the method comprises the steps: moving the gripping fingers (3) in z-direction to insert a sample container (1) into a sample container rack (2) or remove a sample container (1) from a sample container rack (2), determining, if the gripping fingers (3) get in contact with the sample container rack (2), and performing an error procedure, if the gripping fingers (3) get in contact with the sample container rack (2).

IPC Classes  ?

• B25J 15/08 - Gripping heads having finger members
• B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

The present invention relates to a method, a diagnostic system, a kit and the use thereof for efficiently detection of an analyte of interest by a chip based nanoESI detection system.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic reagents for scientific or research use; Chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology, Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; Nucleic acid amplification reagents [other than for medical use]. In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Chemical preparations for use in dna analysis [medical]; Nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Diagnostic apparatus for research laboratory use; DNA microarray; Devices for analyzing protein sequence used as laboratory apparatus; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Computer software for use in medical decision support systems; Workflow management system software; Bioinformatics software. Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes used in medical laboratories; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for DNA and RNA testing for medical purposes; Apparatus for analysing substances [for medical use].

Goods & Services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Diagnostic reagents for scientific or research use; Chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology, Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; Nucleic acid amplification reagents [other than for medical use]. In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Chemical preparations for use in dna analysis [medical]; Nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Diagnostic apparatus for research laboratory use; DNA microarray; Devices for analyzing protein sequence used as laboratory apparatus; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Computer software for use in medical decision support systems; Workflow management system software; Bioinformatics software. Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes used in medical laboratories; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for DNA and RNA testing for medical purposes; Apparatus for analysing substances [for medical use].

Abstract

In a first aspect, the invention relates to a derivatisation agent, preferably derivatisation agent for analytes intended to be analysed via LDI-MS, comprising a structural element of formula (I) C- L1 -Z - (L2)p - X, wherein C is a chromophore having an absorption maximum in the range of from 280 to 400 nm; Z is a charged unit comprising at least one permanently charged moiety; X is a reactive group; L1, L2 are each a linker unit; and p is either zero or 1. A second aspect of the invention is related to a kit comprising the derivatisation agent according to the first aspect. In a third aspect, the invention is directed to a use of the derivatisation agent according to the first aspect for the mass spectrometric determination of an analyte molecule, wherein the mass spectrometric determination is LDI-MS. A fourth aspect of the invention relates to a conjugate of a derivatisation agent according to the first aspect and an analyte, wherein the conjugate has the structure of formula (II) C- L1 - Z - (L2)p - Xa - Ya - A, wherein C, L1, L2, p, Z and N are as defined in the context of the first aspect; Xa is a remainder of a reactive group X as defined in the context of the first aspect; A is the analyte and Ya is the remainder of a reactive group Y bound to the analyte A, which has reacted with the reactive group X of the derivatisation agent thus forming a covalent bound between Xa and Ya. A fifth aspect of the invention is related to a method for the mass spectrometric determination of an analyte molecule comprising the steps: (a) providing an analyte of interest; (b) providing a derivatisation agent comprising a structure of formula (I) as defined in the context of the first aspect; (c) reacting the analyte provided according to (a) with the derivatisation agent provided according to (b), whereby a conjugate of the analyte and the derivatisation agent is formed, and (d) subjecting the conjugate formed in (c) to a mass spectrometric analysis, wherein the mass spectrometric analysis is preferably LDI-MS.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones

Abstract

The present invention relates to a method for determining at least one analyte of interest and the uses thereof. The present invention further relates to a diagnostic system, a kit and the use thereof for determining at least one analyte of interest.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01N 21/64 - FluorescencePhosphorescence
• G01J 3/44 - Raman spectrometryScattering spectrometry

Abstract

The invention relates to a method of diagnosing or determining the prognosis of cancer in a patient, the method comprising processing, using RNA‐sequencing and a first machine learning model, the genomic data of the patient to determine at least one of a first cancer type or degree of cancer and processing, using histopathology and a second machine learning model, the biopsy image data of the patient to determine at least one of a second cancer type or degree of cancer and comparing the determined first type or degree of cancer with the determined second type or degree of cancer and correlating the two.

IPC Classes  ?

• G16B 40/20 - Supervised data analysis

Abstract

A gripping device (150) configured for gripping at least one slide (168) is disclosed. The gripping device (150) comprises: • at least one first gripping element (110), wherein the first gripping element (110) comprises at least one first contact surface (112) for gripping the slide (168); • at least one second gripping element (134), wherein the second gripping element (134) comprises at least one second contact surface (136) for gripping the slide (168), wherein the second gripping element (134) further comprises at least two protrusions (160) which respectively extend essentially perpendicular to the second contact surface (136), wherein the at least two protrusions (160) are located on opposing ends (162) of the second contact surface (136), wherein the at least two protrusions (160) are configured for centering the slide (168) during gripping the slide (168) via the gripping device (150); wherein the first gripping element (110) and the second gripping element (134) are linearly movable relative to one another, wherein the first contact surface (112) of the first gripping element (110) and the second contact surface (136) of the second gripping element (134) face each other.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• B01L 9/00 - Supporting devicesHolding devices

Abstract

The present invention generally relates to the field of isotope labeled and non-labeled gentamicin congeners and synthetic methods for the preparation of such congeners. In particular, the present invention relates to isotope labeled gentamicin C or a salt or solvate or derivative thereof, the gentamicin C comprising at least one 13C, D and/or 15N atom and methods for the preparation of gentamicin C or salt or solvate or derivate thereof, in particular of gentamicin C comprising at least one 13C, D and/or 15N atom or salt or solvate or derivate thereof.

IPC Classes  ?

• C07H 15/236 - Cyclohexane rings, substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamicin
• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins

Abstract

A sample carrier transport device (116) for transporting sample carriers (110) to a work- station (112) for sample processing is disclosed. The sample carrier transport device (116) comprises a surface (128) having a plurality of sample carrier holder portions (130). Each of the sample carrier holder portions (130) is configured for removably holding at least one sample carrier (110) during transport of the sample carrier (110) to the workstation (112). The surface (128) is configured for performing a movement for transporting the sample carrier (110) to the workstation (112). The sample carrier transport device (116) comprises at least one lifting mechanism configured for moving the surface (128) to at least one transport position and to at least one transfer position. The transport position and the transfer position refer to different heights of the surface (128). The lifting mechanism is configured for holding the surface (128) during transport of the sample carriers (110) to the workstation (112) in the transport position. The sample carrier transport device (116) is configured for handing over the sample carrier (110) to the workstation (112) and for receiving the sample carrier (110) from the workstation (112) in the transfer position.

IPC Classes  ?

• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

A method for predicting a maintenance condition of a filtration system of a diagnostic apparatus or a laboratory analyser at a given time is done by performing the following steps. First a plurality of successive raw permeability values of the permeability of a fluid through the filtration device over a specified measurement period is measured. Then smoothed permeability values are determined by means of a data processing method to reduce the fluctuations of the raw permeability values over time. Afterwards a regression analysis function is applied through the successive permeability values, wherein the regression analysis function comprises fitting parameters being adapted so that the fitting function is fitted to the measured permeability values. Finally, the time, when the regression analysis function will cross a predetermined threshold value is determined, wherein the crossing of the threshold value is judged as a maintenance condition.

IPC Classes  ?

• B01D 65/02 - Membrane cleaning or sterilisation
• B01D 65/08 - Prevention of membrane fouling or of concentration polarisation