Abrégé

A first aspect of the invention is directed to a method of preparing a cationically functionalized magnetic particle comprising a polymer matrix (P) and at least one magnetic core (M), wherein the polymer matrix comprises at least one polymer carrying a molecule comprising at least one nitrogen atom within its structure of formula (I), which has at least one positive charge; the method comprising a reaction of a magnetic particle provided with a molecule comprising at least one amine group within its structure of formula (II) in an aqueous medium. In a second aspect, the invention is related to a cationically functionalized magnetic particle, preferably obtained or obtainable from the method of the first aspect of the invention. A third aspect of the invention is directed to the use of the cationically functionalized magnetic particle of the second aspect of the invention for qualitative and/or quantitative determination of at least one analyte in a fluid or in a gas, and a fourth aspect of the invention relates to a method for determining at least one analyte in a fluid with the cationically functionalized magnetic particle of the second aspect of the invention.

Classes IPC  ?

• H01F 1/00 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques
• A61K 49/12 - Composés macromoléculaires
• C08F 8/32 - Introduction d'atomes d'azote ou de groupes contenant de l'azote par réaction avec des amines

Produits et services

Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; enzymes for scientific purposes; chemical reagents for use in genetic research.

Produits et services

Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; enzymes for scientific purposes; chemical reagents for use in genetic research.

Abrégé

Fusion polypeptides are disclosed which are substrates for Kutzneria albida transglutaminase. The fusion polypeptides comprise one or more FKBP chaperone(s) and a target polypeptide. Each of these elements is separated from the neighboring element by a linker amino acid sequence. It was found that inserting glutamic acid containing transglutaminase recognition motifs into the linker amino acid chains is advantageous. Subsequent labeling reactions catalyzed by the transglutaminase surprisingly provide labeled fusion polypeptides have superior properties when compared with chemically random-labeled fusion polypeptides of similar design. Assays and kits are provided for in vitro detection of target antibodies in samples.

Classes IPC  ?

• C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs
• C07K 1/13 - Marquage de peptides
• C12N 9/90 - Isomérases (5.)

Abrégé

The disclosure relates to the production of highly pure N,N-diisopropylphosphoramidite compounds, such as 6-bromohexyl 2-cyanoethyl N,N-diisopropylphosphoramidite, and highly pure starting material used therein, such as 6-bromohexan-1-ol. The resulting N,N- diisopropylphosphoramidite compounds are useful, for example, for the improved preparation of expandable nucleotide triphosphates (XNTPs) for use in sequencing by expansion.

Classes IPC  ?

• C07F 9/24 - Esteramides
• C07H 1/00 - Procédés de préparation des dérivés du sucre

Abrégé

The present invention concerns the field of diagnostics. In particular. It relates to a method for assessing a heart valve disease or disorder comprising the steps of a) determining the amount of a BMPlO-type peptide in a sample of said subject, and b) comparing the amount determined in step a) to a reference, whereby the heart valve disease or disorder is assessed. Further, the invention concerns computer-implemented methods of the aforementioned methods as well as devices and kits for carrying out said methods. Yet, the present invention contemplates the general use of a BMPlO-type peptide in a sample of a subject or a detection agent for a BMPlO-type peptide to be applied in said sample for assessing a heart valve disease or disorder.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention relates to a method for self-monitoring a woman being at risk of developing or having preeclampsia, an electronic consumer device configured for use in the method, a computer program and a medical test-kit adapted for the use in the method.

Classes IPC  ?

• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne

Produits et services

Research in the field of artificial intelligence; Computer software design; Computer software development; Medical research; Medical research laboratory services; Research and development in the pharmaceutical and biotechnology fields; Information technology services for the pharmaceutical and healthcare industries; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Scientific research for medical purposes in the area of cancerous diseases; Scientific laboratory services; Consultancy in the field of pharmaceutical research; Medical research in the field of pathology; Providing temporary use of online non-downloadable software for accessing and using a cloud computing network; Analytic laboratory services. Medical testing for diagnostic and treatment purposes; Medical analysis services for diagnostic and treatment purposes provided by medical laboratories.

Abrégé

Sample-processing device (100) for magnetic bead-based sample processing, the sample-processing device (100) comprises: A magnetic bead attraction element (10) comprising at least one first magnet section (11a) and at least one second magnet section (12a) being oriented at an angle of 90° < α < 180° with respect to the at least one first magnet section (11a); and A test tube-receiving mechanism (13) for receiving at least one test tube (14) with a main tube wall section (15) and a tapered bottom wall section (16) for containing a sample liquid (17) with magnetic beads (18), wherein the magnetic bead attraction element (10) and the test tube-receiving mechanism (13) are at least partially movably arranged relative to each other between: a first bead collection configuration (A), in which the magnetic bead attraction element (10) is positioned with respect to the test tube (14), when being received by the test tube-receiving mechanism (13), such that the at least one first magnet section (11a) overlaps with at least a portion of the main tube wall section (15) and the at least one second magnet section (12a) overlaps with at least a portion of the tapered bottom wall section (16); and a second bead collection configuration (B), in which the magnetic bead attraction element (10) is positioned with respect to the test tube (14) when being received by the test tube-receiving mechanism (13), such that the at least one first magnet section (11a) overlaps with at least a portion of the tapered bottom wall section (16).

Classes IPC  ?

• B03C 1/01 - Prétraitement spécialement adapté à la séparation magnétique par addition d'agents magnétiques
• B03C 1/033 - Éléments constitutifsOpérations auxiliaires caractérisés par le circuit magnétique
• B03C 1/28 - Bouchons et jauges magnétiques
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet

Abrégé

Computer-implemented methods for analysing multimodal data are described. A computer-implemented method comprises generating an output data set by processing an input data set comprising data from one or more of a set of at least three modalities, using a machine learning model comprising a transitive and commutative machine-learning model. Related methods, products and systems are described.

Classes IPC  ?

• G06N 3/045 - Combinaisons de réseaux

Abrégé

A device for sensing biomolecules, the device including a first layer having a first surface energy configured for binding with particular types of complexes of tethers, target biomolecules, and magnetic nanoparticles. A second layer is positioned on the first layer, the second layer having a second surface energy substantially inert to the tethers, target biomolecules, and magnetic nanoparticles of the complexes. One or more nanowells are formed within the second layer, each exposing a surface of the first layer, the nanowells configured to selectively bind the particular types of complexes with the exposed surfaces of the first layer. One or more magnetic sensors are arranged from beneath the exposed surface of each of the nanowells, the magnetic sensors configured to respectively detect the presence of the target biomolecules through detection of the magnetic nanoparticles within the complexes.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 27/327 - Électrodes biochimiques
• G01N 27/74 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques des fluides
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
• B32B 9/00 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes
• B32B 9/04 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes comprenant une telle substance comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique
• B32B 15/04 - Produits stratifiés composés essentiellement de métal comprenant un métal comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique
• B32B 27/28 - Produits stratifiés composés essentiellement de résine synthétique comprenant des copolymères de résines synthétiques non complètement couverts par les sous-groupes suivants
• B82Y 25/00 - Nanomagnétisme, p. ex. magnéto-impédance, magnétorésistance anisotropique, magnétorésistance géante ou magnétorésistance à effet tunnel
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• C09D 5/16 - Peintures antisalissuresPeintures subaquatiques
• C23C 16/26 - Dépôt uniquement de carbone
• C23C 16/40 - Oxydes
• G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides

Abrégé

To provide a container storage device that reduces a decrease in processing capacity of an automatic analyzer to be connected and a delay in a measurement result of a measurement request sample and efficiently conveys the sample. A container storage device 1 includes a buffer 21 in which a rack 23 configured to accommodate a first container 22 and a second container 22 is placed, and a control unit 101. The control unit 101 includes a reception unit 102 configured to receive conveying commands for the first container 22 and the second container 22 from an analyzer 11, is configured to confirm whether a predetermined time elapses since the reception unit 102 receives the conveying command for the first container 22, and is configured to perform control such that when the conveying command for the second container 22 is received before the predetermined time elapses, the rack 23 on which the first container 22 and the second container 22 are placed is conveyed to the analyzer 11 at a timing at which the conveying command for the second container 22 is received, and when the conveying command for the second container 22 is not received even after the predetermined time elapses, the rack 23 on which the first container 22 is placed is conveyed to the analyzer 11.

Classes IPC  ?

• G01N 35/04 - Détails du transporteur
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet

Abrégé

A drug discovery ecosystem may receive one or more user inputs configuring an artificial intelligence (Al) agent for orchestrating a drug discovery workflow applying one or more drug discovery tools. The artificial intelligence (Al) agent may be created in accordance with the one or more user inputs. The artificial intelligence (Al) agent is served to one or more users as part a selection of artificial intelligence (Al) agents. One or more user inputs selecting the artificial intelligence (Al) agent may be received. The artificial intelligence (Al) agent may be executed to orchestrate the drug discovery workflow in response to the one or more user inputs selecting the artificial intelligence (Al) agent. Related systems, computer-implemented methods, and computer program products are provided.

Classes IPC  ?

• G16C 20/50 - Conception moléculaire, p. ex. de médicaments
• G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie
• G16C 20/90 - Langages de programmationArchitectures informatiquesSystèmes de bases de donnéesStockage de données
• G16B 50/00 - TIC pour la programmation d’outils ou de systèmes de bases de données spécialement adaptées à la bio-informatique
• G16C 20/30 - Prévision des propriétés des composés, des compositions ou des mélanges chimiques
• G16B 15/30 - Ciblage de médicament à l’aide de données structurellesPrévision d’amarrage ou de liaison moléculaire
• G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs

Produits et services

(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; enzymes for scientific purposes; chemical reagents for use in genetic research.

Produits et services

laboratory instruments for the analysis of biological samples for use in research, science and industry; quantitative polymerase chain reaction (pcr) instruments for use in research, science and industry; downloadable computer software for use in medical decision support systems; downloadable laboratory workflow management system software; downloadable bioinformatics software; computer hardware and downloadable computer software for use with laboratory instruments, namely, for use in providing automation of laboratory processes, control and monitoring of laboratory instruments, connectivity, data analysis, and data management; integrated software packages for use in the automation of laboratories; downloadable software for healthcare information management and analysis for medical research and clinical research use Medical apparatus and instruments for medical and diagnostic purposes for the analysis of biological samples; medical apparatus, namely, clinical chemistry analyzers and immunochemistry analyzers for use in the analysis of biological samples for the presence, absence, or quantity of medically significant analytes for clinical medical diagnostic purposes; quantitative polymerase chain reaction (pcr) instruments for clinical medical diagnostic use

Produits et services

(1) Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; enzymes for scientific purposes; chemical reagents for use in genetic research.

Abrégé

Provided is an automatic analysis device that is capable of suppressing intake, by a liquid intake nozzle, of bubbles that remain in a container after having been discharged thereinto from a liquid discharge nozzle. An automatic analysis device 100 comprises: an analysis part 45 that analyzes a specimen; a cup 39 that accommodates a liquid necessary for detection of the specimen; a first nozzle 38 that discharges the liquid into the cup 39; and a second nozzle 42 that intakes the liquid from the cup 39 and that feeds the liquid to the analysis part 45. The cup 39 is provided with a first region 54 into which the liquid is discharged from the first nozzle 38, a second region 55 from which the second nozzle 42 intakes the liquid, and a bubble blocking part 30a, 30b which is between the first region 54 and the second region 55, through which the liquid passes, and which blocks bubbles created by discharge of the liquid.

Classes IPC  ?

• G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection

Produits et services

Scientific apparatus and instruments; Laboratory instruments [other than for medical use]; Instruments for diagnosis [for scientific use]; Quantitative Polymerase Chain Reaction [PCR] instruments for scientific use; Real-time Polymerase Chain Reaction [PCR] instruments for scientific use; Diagnostic apparatus for research laboratory use; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; Laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; Computer software for use in medical decision support systems; Workflow management system software; Bioinformatics software; Computer software relating to the medical field; Integrated software packages for use in the automation of laboratories; Downloadable computer software for remote monitoring and analysis; Downloadable software applications. Medical apparatus and instruments; Testing apparatus for medical purposes; Diagnostic apparatus for medical purposes; Devices for measuring blood sugar; Real-time Polymerase Chain Reaction [PCR] instruments for medical use; Diagnostic testing instruments for use in immunoassay procedure [medical]; Immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; Apparatus for analysing substances [for medical use]; Diagnostic apparatus for medical purposes for use in medical laboratories.

Produits et services

Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; antibody reagents for scientific purposes; immunoassay reagents, other than for medical use; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; enzymes for scientific purposes; chemical reagents for use in genetic research. Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use for medical purposes; diagnostic biomarker reagents for medical purposes; immunoassay reagents for medical use; nucleic acid sequences for medical and veterinary purposes

Abrégé

The present invention relates to antibodies or antigen binding fragments thereof binding to Hemoglobin A1c (HbA1c) and nucleic acids coding for at least a part of antibodies or antigen binding fragments thereof binding to Hemoglobin A1c (HbA1c) of the present invention. Furthermore, the present invention relates to the use of antibodies or antigen binding fragments thereof binding to Hemoglobin A1c (HbA1c), compositions or diagnostic compositions of the present invention for determining the amount or concentration of HbA1c in a sample and to methods of for determining the amount or concentration of HbA1c in a sample.

Classes IPC  ?

• G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

The present invention concerns the field of diagnostics. In particular, it relates to a method for analyzing a protein analyte in a heparin-treated sample comprising or suspected to comprise said protein analyte, said method comprising the step of contacting said heparin-treated sample with spermidine prior to analyzing the said protein analyte in the said sample. Moreover, contemplated are a method for assessing a cardiovascular disease or disorder, a neurological disease or disorder, a metabolic disease or disorder or cancer as well as kits and reagent compositions comprising spermidine to be used in the said methods.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Produits et services

Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; antibody reagents for scientific purposes; immunoassay reagents, other than for medical use; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; enzymes for scientific purposes; chemical reagents for use in genetic research. Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes; immunoassay reagents for medical use; nucleic acid sequences for medical and veterinary purposes.

Abrégé

This automated analyzer comprises: a dispensing unit that dispenses a specimen and a reagent into a first container; an analysis unit that analyzes components of the specimen by using a liquid mixture composed of the specimen and the reagent; a nozzle that suctions the liquid mixture from the first container and sends the liquid mixture to the analysis unit; and a control unit that controls the dispensing unit, the analysis unit, and the nozzle. The automated analyzer has set therein: an analysis step in which at least a first process for dispensing the specimen and the reagent into the first container, a second process for sending the liquid mixture from the first container to the analysis unit, and a third process for analyzing the components of the specimen by using the liquid mixture in the analysis unit are performed in the stated order; and a cleaning step in which at least a fourth process for sending a cleaning liquid from a second container to the analysis unit via the nozzle is executed. The control unit schedules the cleaning step to be executed between a plurality of analysis steps executed sequentially in the analysis unit. Consequently, carry-over can be reduced even when a low sensitivity item and a high sensitivity item are measured continuously.

Classes IPC  ?

• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection

Abrégé

The present disclosure provides for devices, compositions, and methods for improving signal variability in electrochemical detection, such as electrochemical detection with a biochip, such as a biochip including a gold electrode.

Classes IPC  ?

• G01N 27/327 - Électrodes biochimiques
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

A first aspect of the invention relates to an aqueous formulation of a protein-loaded magnetic particle, the formulation comprising: (i) at least one protein-loaded magnetic particle; (ii) at least one aqueous phase; wherein the at least one protein-loaded magnetic particle of (i) is at least partially suspended in the at least one aqueous phase of (ii), the formulation further comprising: (iii) at least one detergent in a concentration of in the range of from 0.01 to 0.04 % (w/v); (iv) at least one blocking reagent in a concentration ≤ 0.02 mg/ml; (v) at least one inorganic salt in a concentration ≤ 300 mM; and (vi) at least one buffering system; wherein the at least one protein-loaded magnetic particle of (i) is present in the aqueous formulation in a concentration of ≥ 10 mg/ml; and the aqueous formulation has a pH in the range of from 6 to 7. In a second aspect, the invention relates to the use of an aqueous formulation according to the first aspect of the invention for storage, transportation, homogenization, filling, decanting and/or diagnostic purpose. A third aspect of the invention is directed to an aqueous composition, preferably for containing a protein-loaded magnetic particle, the composition comprising water and in dissolved and/or suspended form (iii), (iv), (v) and (vi) as in the formulation of the first aspect of the invention, wherein the aqueous composition has a pH in the range of from 6 to 7. A fourth aspect of the invention relates to the use of the aqueous composition of the third aspect for suspending at least one protein-loaded magnetic particle.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques

Abrégé

The invention relates to a laboratory sample distribution device (1), comprising: a base (2) having a transport surface (3), at least one drive-controllable lane belt (4) defining a transport lane (5), the lane belt (4) being cleated for form-fit engagement with a respective sample container carrier (50) to be moved over the transport surface (3) along the transport lane (5), at least one drive-controllable cross-track belt (6) defining a transport cross-track (7), the cross-track belt (6) being cleated for form-fit engagement with a respective sample container carrier (50) to be moved over the transport surface (3) along the transport cross-track (7), the transport cross-track (7) meeting the transport lane (5) at an angle (α), an operation mode in which the lane belt (4) and the cross-track belt (6) are controlled for transferring a respective sample container carrier (50) between the transport lane (5) and the transport cross-track (7), and another operation mode in which the lane belt (4) and the cross-track belt (6) are controlled for moving a respective sample container carrier (50) along the transport lane (5) past the transport cross-track (7).

Classes IPC  ?

• G01N 35/04 - Détails du transporteur

Abrégé

The invention is directed in a first aspect to an aqueous formulation of a protein-loaded magnetic particle, the formulation comprising (i) at least one protein-loaded magnetic particle present in an aqueous phase in a concentration of ≥ 10 mg/ml; and (ii) at least one non-chelating biocide, wherein the at least one non-chelating biocide is at least partially dissolved respectively in the aqueous phase of (i), and the aqueous formulation, especially the aqueous phase, has a pH value in the range of from 6 to 7. A second aspect of the invention is directed to the use of the aqueous formulation according to the first aspect of the invention for storage, transportation, homogenization, purification, filling, decanting and/or diagnostic purpose.

Classes IPC  ?

• G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention provides novel antibodies specifically binding to ERG and compositions and kits comprising such antibodies. Furthermore, provided are polynucleotides encoding such antibodies, host cells expressing said antibodies, methods of producing such antibodies and diagnostic methods using such antibodies.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire

Abrégé

The present invention relates to methods of diagnosing whether a subject has endometriosis, to methods of determining the therapeutic effect of a treatment regimen for endometriosis, and methods of monitoring endometriosis progression in a subject, to methods for classifying the stage of endometriosis in a subject, by determining the amount or concentration of ERG in a sample of the subject, and comparing the determined level to a reference value.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Total internal reflection fluorescence (TIRF) microscope (100) comprising: an excitation light source (101) and an excitation light path (108), the excitation light source (101) being configured to emit an excitation light (110) propagating along the excitation light path (108) towards a sample (106) with at least one fluorophore and to generate an evanescent wave that is configured to permeate the sample and that is configured to excite an emission of fluorescence emission light (107) by the sample (106); an optical microscope setup (300) configured to project an image of at least a portion of the sample (106) positioned in an object plane (OP) onto an image plane (IP) of the optical microscope setup (300); a sensor (304) configured to be positioned in the image plane (IP) and to record the fluorescence emission light (107) emitted by the sample (106); and a total internal reflection (TIR) prism (201; 501; 600; 700) configured to support the sample (106), the total internal reflection (TIR) prism (201; 501; 600; 700) comprising: a base surface (A) facing away from the sensor; a sample-supporting surface (B) opposite to the base surface (A) and facing the sensor; an excitation light incidence surface (C) oriented at an angle 0° < ∝ < 90° with respect to the sample-supporting surface (B) and the excitation light path (108) being configured such that at least a portion of the excitation light (110) hits the excitation light incidence surface (C) and propagates via the TIR prism (200; 500; 600; 700) to the sample-supporting surface (B); an excitation light exit surface (D) opposite the excitation light incidence surface (C); and at least one light trap element (202; 502; 602; 703) matching the refractive index of the TIR prism (200; 500; 600; 700) and being optically coupled to the excitation light exit surface (D) of the TIR prism (200; 500; 600; 700).

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/16 - Microscopes adaptés pour éclairage ultraviolet
• G02B 27/56 - Optique utilisant des ondes évanescentes, c.-à-d. ondes non homogènes
• G02B 5/04 - Prismes
• G02B 21/00 - Microscopes
• G02B 5/00 - Éléments optiques autres que les lentilles

Abrégé

The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with infection comprising the steps of determining the amount or concentration of a biomarker in a sample of the subject, said biomarker being PPBP, comparing the amount of the biomarker to a reference for said biomarker and assessing said subject based on the comparison. The invention also relates to the use of a biomarker being PPBP or a detection agent specifically binding to said biomarker for assessing a subject with infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with infection and a device and a kit for assessing a subject with infection.

Classes IPC  ?

• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention relates to a method for assessing asymptomatic heart failure said method comprising cMyBP-C (Myosin binding protein C, cardiac type), and optionally the level of at least one further biomarker selected from the group consisting of MyL7 (Myosin light chain 7), at least one cardiac Troponin, Angiopoietin-2 (Ang-2), and at least one BNP -type peptide in a sample from the subject. The present invention further relates to computer-implemented methods, databases, devices, kits and uses related thereto.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The disclosure relates to ssDNA cleavage using restriction enzymes, as well as its use for sequence specific hydrolysis of oligonucleotides prior to LC-MS/MS analysis resulting in formation of shorter oligonucleotide sequences to enable high sequence coverage by MS/MS fragmentation.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/683 - Tests d’hybridation pour la détection de mutation ou de polymorphisme faisant intervenir des enzymes de restriction, p. ex. polymorphisme de longueur de fragment de resctriction

Abrégé

The present invention relates to methods to prepare an isotopically labelled N-(4- hydroxyphenyl)acetamid, methods to prepare isotopically labelled 4-aminophenol and isotopically labelled 4-((4-nitrophenyldiazenyl)phenol. The present invention further relates to uses of an isotopically labelled N-(4-hydroxyphenyl)acetamid as an internal standard to determine the presence, amount or concentration of N-(4- hydroxyphenyl)acetamid in a sample and to methods of determining the amount of N-(4-hydroxyphenyl)acetamid in a sample. The present invention also relates to diagnostic compositions comprising an isotopically labelled N-(4- hydroxyphenyl)acetamid and kits for determining the presence, amount or concentration of N-(4-hydroxyphenyl)acetamid in a sample.

Classes IPC  ?

• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
• C07C 213/02 - Préparation de composés contenant des groupes amino et hydroxy, amino et hydroxy éthérifiés ou amino et hydroxy estérifiés liés au même squelette carboné par des réactions impliquant la formation de groupes amino à partir de composés contenant des groupes hydroxy ou des groupes hydroxy éthérifiés ou estérifiés
• C07C 231/02 - Préparation d'amides d'acides carboxyliques à partir d'acides carboxyliques ou à partir de leurs esters, anhydrides ou halogénures par réaction avec de l'ammoniac ou des amines
• C07C 245/08 - Composés azo, c.-à-d. composés ayant les valences libres de groupes —N=N— attachées à des atomes différents, p. ex. diazohydroxydes avec des atomes d'azote de groupes azo liés à des atomes de carbone de cycles aromatiques à six chaînons avec les deux atomes d'azote de groupes azo liés à des atomes de carbone de cycles aromatiques à six chaînons, p. ex. azobenzène

Abrégé

Diagnostic method (100) of determining the presence of a label-free antibody-antigen complex of interest in a biological sample: Providing (101) a trained model based on a training data set processed by multivariate statistics and a machine learning algorithm, wherein the training data set comprises: immunoassay training data of the labeled antibody-antigen complex obtained from at least one immunoassay technique; spectral training data comprising one or more training vibrational spectra of the labeled and/or label-free antibody-antigen complex obtained from at least one vibrational spectroscopy technique; Recording (102) at least one sample vibrational spectrum of a biological sample using the at least one vibrational spectroscopy technique; and Applying (103) the trained model onto the at least one sample vibrational spectrum and determine whether or not the label-free antibody-antigen complex is present in the biological sample.

Classes IPC  ?

• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 21/65 - Diffusion de Raman
• G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 21/33 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière ultraviolette
• G01N 21/35 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge

Abrégé

The invention relates in a first aspect to a method for derivatizing an analyte of interest, wherein the method comprises the provision of (a) a liposome particle comprising a derivatization agent for an analyte intended to be analyzed via mass spectrometry, an encapsulating material surrounding the derivatization agent, and a first member of a binding pair bonded to at least a part of the encapsulating material and facing towards the outside of the particle; (b) a magnetic particle having on its surface a second member of the binding pair, and optionally a binding agent specific for the analyte of interest; (c) a liquid sample potentially containing an analyte of interest; and (d) optionally a further magnetic particle comprising a binding agent specific for the analyte of interest. The first aspect also relates to a method for determining an analyte of interest, the method further comprising subjecting the derivatized analyte of interest obtained to analysis. A second aspect of the invention is directed to a derivatized analyte of interest, obtained or obtainable from the method of the first aspect of the invention. In a third aspect, the invention is related to a liposome particle comprising a derivatization agent for an analyte intended to be analyzed via mass spectrometry, an encapsulating material surrounding the derivatization agent, and a first member of a binding pair bonded to at least a part of the encapsulating material, wherein the encapsulating material comprises one or more lipid(s) or to a liquid mixture comprising said liposome particle in suspended form. A fourth aspect of the invention is related to the use of the liposome particle or the liquid mixture of the third aspect of the invention for derivatization of an analyte of interest or in a method for determining an analyte of interest.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

This gear pump performance prediction system for an automatic analysis device makes it possible to accurately predict the service life and replacement time of a gear pump of an automatic analysis device. The gear pump performance prediction system comprises: dispensing mechanisms 7, 8, 11, 12; a gear pump 41 that supplies washing water; a water supply pump 54; a first liquid delivery flow path 115 that delivers water from the water supply pump 54 to the gear pump 41; a second liquid delivery flow path 116 that delivers washing water from the water supply pump 54 to the dispensing mechanisms 7, 8, 11, 12; a pressure sensor 111 that measures the pressure values of the first liquid delivery flow path 115 and the second liquid delivery flow path 116; and a control unit 112 that adjusts the flow rate of the gear pump 41 by comparing an adjustment target pressure for the second liquid delivery flow path 116 and a measured pressure value 303. The state of the gear pump 41 is predicted by a gear pump performance evaluation unit 132 on the basis of a performance evaluation factor for the gear pump 41, and the state of the gear pump 41 predicted by the gear pump performance evaluation unit 132 is output to a data output unit 131 that outputs the predicted state of the gear pump 41.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• F04C 14/28 - Dispositions de sécuritéSurveillance
• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection

Abrégé

Provided is a flow path abnormality detection system for detecting an abnormality on the basis of data obtained from an automatic analysis device, wherein the automatic analysis device includes: a sensor for applying a voltage to a reaction liquid, which is obtained by an antigen-antibody reaction between a specimen and a reagent, to cause an electrochemical reaction; a flow path for introducing, into the sensor, the reaction liquid and an auxiliary reagent for energization; and a photoelectric conversion sensor for measuring the emission intensity due to the electrochemical reaction. The flow path abnormality detection system comprises: a processor for calculating a feature amount from electrical signal data over time during a period in which the electrochemical reaction is being performed, and identifying an abnormality in the flow path from the feature amount; and a data output interface for outputting a signal pertaining to the result of the abnormality identified by the processor, wherein the processor obtains, from acquired electrical signal data, the feature amount on the basis of the emission intensity measured by the photoelectric conversion sensor. Thus, provided are a flow path abnormality detection system, an automatic analysis device, and a flow path abnormality detection method with which it is possible to automatically detect an abnormality in a flow path of the automatic analysis device.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• G01N 27/26 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables électrochimiquesRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en utilisant l'électrolyse ou l'électrophorèse
• G01N 27/28 - Composants de cellules électrolytiques
• G01N 27/416 - Systèmes
• G01N 35/08 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant un courant d'échantillons discrets circulant dans une canalisation, p. ex. analyse à injection dans un écoulement

Abrégé

This automated analysis device comprises: a pump that feeds a mobile phase; a separating column through which the mobile phase fed by the pump and a specimen being analyzed are passed to separate components in the specimen; an acquiring unit that acquires pressure data when the pump feeds the mobile phase; a storage unit that stores a normal value of the pressure data; and a calculating unit that, each time a specimen is measured using the separating column, calculates first data indicating the degree of deviation of the pressure data from the normal value on the basis of a statistical method that takes into account the degree of similarity between the pressure data and the normal value, and calculates the remaining service life of the separating column on the basis of the first data. This makes it possible to provide an automated analysis device in which it is possible to predict more accurately the remaining service life of a separating column used in a liquid chromatograph.

Classes IPC  ?

• G01N 30/86 - Analyse des signaux
• G01N 30/32 - Contrôle des paramètres physiques du fluide vecteur de la pression ou de la vitesse

Abrégé

The present invention relates to a method for assessing colorectal cancer or a precancerous condition thereof, said method comprising a) detecting the presence or absence of an antibody to ANPEP (Aminopeptidase N, anti-ANPEP antibody) in a blood, serum or plasma sample from the subject, and assessing colorectal cancer or the precancerous condition thereof based on the presence or absence of an antibody to ANPEP determined in step a). The present invention further relates to computer-implemented methods, databases, devices, kits and uses related thereto.

Classes IPC  ?

• G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
• G01N 33/57535 -

Abrégé

The present invention relates to a method for assessing colorectal cancer or a precancerous condition thereof, said method comprising (a) determining the level of SRY-box transcription factor 9 (SOX9) in a blood, serum or plasma sample from the subject, and assessing colorectal cancer or the precancerous condition thereof based on the level of SOX9 determined in step a). The present invention further relates to computer-implemented methods, databases, devices, and uses related thereto.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a mutated neuraminidase enzyme, or a functional fragment thereof with increased enzymatic activity at alkaline pH, compared to a non-mutated neuraminidase enzyme. The invention further provides nucleic acids encoding the mutant enzyme, a vector, a recombinant cell comprising the nucleic acid and a method for producing the enzyme. Also provided are a method for immunohistochemical (IHC) staining, the use of the mutated enzyme in immunohistochemical (IHC) staining, as well as a kit comprising the mutated enzyme.

Classes IPC  ?

• G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
• C12N 9/24 - Hydrolases (3.) agissant sur les composés glycosyliques (3.2)

Abrégé

The present invention relates to a mutated neuraminidase enzyme, or a functional fragment thereof with increased enzymatic activity at alkaline pH, compared to a non-mutated neuraminidase enzyme. The invention further provides nucleic acids encoding the mutant enzyme, a vector, a recombinant cell comprising the nucleic acid and a method for producing the enzyme. Also provided are a method for immunohistochemical (IHC) staining, the use of the mutated enzyme in immunohistochemical (IHC) staining, as well as a kit comprising the mutated enzyme.

Classes IPC  ?

• C12N 9/24 - Hydrolases (3.) agissant sur les composés glycosyliques (3.2)
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase

Abrégé

The present invention relates to a method for assessing colorectal cancer or a precancerous condition thereof, said method comprising (a) determining the level CLEC3B (C-type lectin domain family 3 member B) in a blood, serum or plasma sample from the subject, and assessing colorectal cancer or the precancerous condition thereof based on the level of CLEC3B determined in step a). The present invention further relates to computer-implemented methods, databases, devices, and uses related thereto.

Classes IPC  ?

• G01N 33/575 -

Produits et services

Chemical preparations for scientific purposes; Biological preparations for use in industry and science; Diagnostic reagents for scientific purposes; Diagnostic reagents for scientific or research use; Chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; Enzymes for scientific and research purposes; Chemical reagents for use in genetic research; Nucleic acids for scientific purposes; all of the foregoing not for agricultural or horticultural use, and not for use in connection with the stimulation of plant growth and biological control

Produits et services

Chemical preparations for scientific purposes; Biological preparations for use in industry and science; Diagnostic reagents for scientific purposes; Diagnostic reagents for scientific or research use; Chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; Enzymes for scientific and research purposes; Chemical reagents for use in genetic research; Nucleic acids for scientific purposes

Produits et services

Chemical preparations for scientific purposes, other than for medical or veterinary use; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; reagents for use in scientific apparatus for chemical or biological analysis; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; nucleic acids for scientific purposes; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; enzymes for scientific purposes; chemical reagents for use in genetic research.

Produits et services

Chemical preparations for scientific purposes, other than for medical or veterinary use; Biological preparations, other than for medical or veterinary purposes; Biochemical preparations for scientific purposes; Diagnostic reagents for scientific or research use; Reagents for use in scientific apparatus for chemical or biological analysis; Chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; Nucleic acids for scientific purposes; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Enzymes for scientific purposes; Chemical reagents for use in genetic research.

Abrégé

A method of characterizing at least one biomedical potentiometric electrochemical sensor (110) is proposed. The biomedical potentiometric electrochemical sensor (110) comprises at least one main electrode (112) with at least one ion-selective membrane, at least one reference electrode (114), and at least one counter electrode (116). The method comprises: (120) connecting the main electrode (112) with the reference electrode (114); (122) determining a potential between the main electrode (112) and the reference electrode (114) by a high-impedance potentiometric measurement; (124) connecting the one main electrode (112) with the counter electrode (116) and applying the determined potential between the main electrode (112) and the counter electrode (116); (126) recording electrochemical impedance data by performing an electrochemical impedance spectroscopy measurement (EIS), wherein the electrochemical impedance spectroscopy measurement comprising applying an alternating voltage; (128) de-connecting the main electrode (112) from the counter electrode (116) after applying the alternating voltage; and (130) characterizing the biomedical potentiometric electrochemical sensor (110) based on the recorded electrochemical impedance data.

Classes IPC  ?

• G01N 27/416 - Systèmes
• G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang

Abrégé

In a detection process including an electrochemical reaction, the present invention stores, out of electric signal data acquired by a sensor, a parameter representing the relationship between the state of the sensor and the amount of change in the electric signal data due to change in the state of the sensor, calculates a state estimation index of the sensor using the electric signal data and the parameter, and calculates a statistical value of the state estimation index. In the detection process, the present invention calculates an evaluated sensor state estimation index of a sensor of interest using the parameter and evaluated sensor electric signal data output from the sensor of interest, compares the evaluated sensor state estimation index with the statistical value, evaluates a characteristic of the sensor of interest, and outputs the result of the characteristic evaluation. Thus, the present invention provides: a characteristic evaluation system with which it is possible to evaluate a characteristic of a sample test sensor of an automatic analysis device; an automatic analysis device; and a characteristic evaluation method.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• G01N 21/66 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité électriquement, p. ex. par électroluminescence
• G01N 27/26 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables électrochimiquesRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en utilisant l'électrolyse ou l'électrophorèse
• G01N 27/416 - Systèmes

Abrégé

RSperrLBLBSS) of the light-emitting diode (1).

Classes IPC  ?

• H05B 45/12 - Commande de l'intensité de la lumière à l'aide d'un retour optique

Produits et services

Diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]. Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes; nucleic acid sequences for medical and veterinary purposes. Scientific research in the field of genetics and genetic engineering; genetic testing for scientific research purposes; scientific advisory services relating to chemical reagents; laboratory testing; biochemical research and analysis.

Abrégé

The present invention relates to methods and compositions for preparing a sample enriched for single stranded nucleic acids. The single stranded nucleic acids find use as templates for synthesizing Xpandomer copies of the nucleic acids. The Xpandomer copies may be passed through a nanopore sensor to determine the nucleic acid sequence of the nucleic acids. The methods include asymmetric PCR, amplicon immobilization melt, exonuclease-mediated partial or complete digestion of one or both strand of an amplicon and linear amplification.

Classes IPC  ?

• C12Q 1/686 - Réaction en chaine par polymérase [PCR]
• C40B 20/04 - Identification des éléments d'une bibliothèque au moyen d'une étiquette, d'un marqueur ou d'un autre identificateur lisible ou détectable, p. ex. procédés de décodage
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 9/22 - Ribonucléases
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]

Abrégé

The present invention relates to a method for extracting a macrocyclic analyte from a sample, said method comprising (a) producing a lysis admixture comprising said sample, a first organic solvent at a concentration of from 2.5% (v/v) to 18% (v/v), and an aqueous component at a concentration of at least 60% (v/v), and contacting said lysis admixture with a solid-phase extraction agent; (b) obtaining solid-phase extraction agent bound sample constituents; and (c) thereby extracting said macrocyclic analyte. The present invention also relates to systems, kits, extracts, and determining methods related thereto.

Classes IPC  ?

• G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
• G01N 1/40 - Concentration des échantillons

Abrégé

The present disclosure relates, in general, to novel and easily accessible fluorescent compounds with improved fluorescence properties for expanding the multiplexing capabilities of fluorescence-based nucleic acid detection technologies, as well as to novel methods of producing the same. Moreover, conjugates, PCR probes and FRET pairs comprising these fluorescent compounds as well as methods for amplification and detection of a target nucleic acid utilizing these fluorescent compounds and methods of labeling are also provided.

Classes IPC  ?

• C09B 11/06 - Dérivés hydroxylés de triarylméthanes dans lesquels un groupe —OH au moins est lié à un noyau aryle
• C09B 23/01 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique
• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
• C12Q 1/6869 - Méthodes de séquençage

Abrégé

In a first aspect, the present invention is directed to a magnetic particle having a saturation magnetization ≥ 15 Am2/kg and having at least one azide group –N=N'-N- bonded to a polymer matrix of the magnetic particle. A second aspect of the invention relates to a process for preparing a magnetic particle, which comprises at least one magnetic core (M), a polymer matrix (P) comprising a crosslinked polymer at least partially surrounding the magnetic core (M), the polymer matrix (P) comprising on its surface at least a functional group reactive towards amine groups and/or hydroxyl groups. In a third aspect, the invention is directed to the magnetic particle obtained or obtainable from the process of the second aspect. A fourth aspect is related to a process for preparing a magnetic particle having a saturation magnetization ≥ 15 Am2/kg of the first aspect, and a fifth aspect relates to the magnetic particle obtained or obtainable from the process of the fourth aspect. A sixth aspect is directed to the use of the magnetic particle having a saturation magnetization ≥ 15 Am2/kg of the first aspect or of the fourth aspect for qualitative and/or quantitative determination of at least one analyte in a fluid or in a gas, and a seventh aspect relates to a method for determining at least one analyte in a fluid using said magnetic particle having a saturation magnetization ≥ 15 Am2/kg.

Classes IPC  ?

• H01F 1/00 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• B82Y 25/00 - Nanomagnétisme, p. ex. magnéto-impédance, magnétorésistance anisotropique, magnétorésistance géante ou magnétorésistance à effet tunnel

Abrégé

A computer-implemented method for determining if adding a batch of data to an extant dataset, thereby creating an updated extant dataset, would result in additional data being shareable under an anonymization scheme, whereby the data in the batch of data and the extant dataset contain or represent personally identifiable information linked to one or more values The method comprises: receiving the batch of data or a representation thereof; determining whether at least a subset of the updated extant dataset including at least a portion of the received batch of data would be compatible with the anonymization scheme; and responsive to determining that it would be, transmitting to a recipient a share enable message so as to cause the creation of an anonymization of the at least a subset of the updated extant dataset in accordance with the anonymization scheme and the publication of this anonymized data.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p. ex. par clés ou règles de contrôle de l’accès
• H04W 12/02 - Protection de la confidentialité ou de l'anonymat, p. ex. protection des informations personnellement identifiables [PII]

Abrégé

The present invention generally relates to the field of metabolite analysis as it applies to compounds, formulations and methods which can be used to detect metabolites such as formaldehyde and methanol. More particularly, the present invention pertains to β-keto amide compounds which are particularly useful as superior and sufficiently chemoselective detection reagent in the detection of metabolites, notable formaldehyde and related compounds, such as methanol. The present invention also pertains to methods for detecting formaldehyde or methanol, as well as to formulations and kits comprising the β-keto amide compounds, and to the use thereof in the detecting formaldehyde or methanol.

Classes IPC  ?

• C07C 235/80 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné avec des atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques ayant des atomes de carbone de groupes carboxamide et des groupes céto liés au même atome de carbone, p. ex. acéto-acétamides

Abrégé

Analytic fluid device (1) comprising: a substrate (2); a channel negative layer (3) printed onto the substrate (2) and forming at least partially a capillary channel (4) that is configured to guide a fluid (9) along a path (5) that is at least partially defined by the capillary channel (4); and at least one porous fluid reservoir (6) coupled to the capillary channel (4) and configured to receive at least a portion of the fluid (9) after being guided along the path (5) and/or provide at least a portion of the fluid (9) before being guided along the path (5).

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

The present invention generally relates to the field of metabolite analysis as it applies to compounds, formulations and methods which can be used to detect metabolites such as formaldehyde and methanol. More particularly, the present invention pertains to β-keto amide compounds which are particularly useful as superior and sufficiently chemoselective detection reagent in the detection of metabolites, notable formaldehyde and related compounds, such as methanol. The present invention also pertains to methods for detecting formaldehyde or methanol, as well as to formulations and kits comprising the β-keto amide compounds, and to the use thereof in the detecting formaldehyde or methanol.

Classes IPC  ?

• C07D 211/84 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle
• C07C 235/80 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné avec des atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques ayant des atomes de carbone de groupes carboxamide et des groupes céto liés au même atome de carbone, p. ex. acéto-acétamides

Produits et services

Diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]. Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes; nucleic acid sequences for medical and veterinary purposes.

Abrégé

The present invention is directed to a handheld device for the detection of electrostatic discharge, comprising an evaluation unit, and a cable antenna, wherein the cable antenna is formed in a coil-like manner with a number n of windings, with n≥2, each winding being wound around a winding axis, a diameter of each winding is less than 30 cm, and the windings of the cable antenna are spaced apart from each other, preferably by means of at least one spacer.

Classes IPC  ?

• G01R 31/12 - Test de la rigidité diélectrique ou de la tension disruptive
• G01R 31/16 - Construction de récipients de testsÉlectrodes pour de tels récipients

Produits et services

Laboratory instruments, namely, clinical chemistry analyzers and immunochemistry analyzers for the analysis of biological samples for the presence, absence, or quantity of medically significant analytes for scientific or medical research purposes; computer hardware and downloadable software for use with laboratory instruments, namely, for use in data analysis and database management Medical apparatus, namely, clinical chemistry analyzers and immunochemistry analyzers for use in the analysis of biological samples for the presence, absence, or quantity of medically significant analytes for clinical medical diagnostic purposes

Abrégé

(Isample(CHct,t))(ΔI(CHct, t)), t)), are disclosed.

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• G01N 27/327 - Électrodes biochimiques

Abrégé

The present invention relates to a hepatitis delta virus (HDV) polypeptide comprising an antigenic domain comprising an amino acid sequence of SEQ ID NO:1 or an amino acid sequence at least 60% identical thereto, wherein said polypeptide (i) is devoid of a coiled-coil domain consisting of the amino acid sequence of SEQ ID NO:2 or an amino acid sequence at least 60% identical thereto; or (ii) further comprises said coiled-coil domain, wherein said coiled-coil domain comprises at least one of the following mutations: (I) the amino acid at position 20 is not tryptophan, and (II) the amino acid at position 50 is not tryptophan. Moreover, the present invention relates to proteins, kits, polynucleotides, host cells, methods, and devices related thereto.

Classes IPC  ?

• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The present invention provides for monoclonal antibodies binding to sulfated and non-sulfated amidated gastrin 17. Further, the present invention provides for kits and compositions comprising such antibodies and diagnostic uses and methods employing such antibodies, compositions, and/or kits. Furthermore, herein provided are, inter alia, nucleic acids encoding such antibodies, host cells comprising the same, as well as means and methods for the production of such antibodies.

Classes IPC  ?

• C07K 16/26 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des hormones
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/66 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les sucres du sang, p. ex. le galactose
• G01N 33/74 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des hormones

Abrégé

The present invention relates in a first aspect to an electrode for an analyte sensor, comprising a layer, which comprises silver chloride (AgCl) and a thermoplastic polyurethane, wherein the thermoplastic polyurethane is obtained or obtainable from an aliphatic polyisocyanate and a polyether polyol. A second aspect of the invention relates to an analyte sensor comprising an electrode of the first aspect of the invention. In a third aspect, the invention is directed to a method for manufacturing an electrode of an analyte sensor. A fourth aspect of the invention is directed to an electrode of an analyte sensor, obtained or obtainable from the method of the second aspect of the invention. In a fifth aspect, the invention is related to a method for manufacturing an analyte sensor as of the second aspect. A sixth aspect of the invention is directed to an analyte sensor, obtained or obtainable from the method of the fifth aspect of the invention. A seventh aspect of the invention is directed to a use of an analyte sensor of the sixth aspect for detecting at least one analyte.

Classes IPC  ?

• G01N 27/30 - Électrodes, p. ex. électrodes pour testsDemi-cellules
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• G01N 27/327 - Électrodes biochimiques

Produits et services

Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; chemical preparations for scientific purposes, other than for medical or veterinary use. Chemical preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; biological preparations for medical purposes.

Abrégé

In-vitro diagnostics (IVD) sensing system (10) for a determination of a presence of a fluid substance (1) based on radio-frequency (RF) technology, the IVD sensing system comprising: one or more antennas (2), wherein at least one first antenna (2a) of the one or more antennas (2) is configured to emit an RF signal (3a) and wherein the at least one first antenna (2a) and/or an at least one second antenna (2b) of the one or more antennas (2) is/are configured to receive the RF signal (3b) emitted by the at least one first antenna (2a); a sample space (4) being positioned with respect to the one or more antennas (2) such that the RF signal (3a) can pass at least a portion of the sample space (4) after being emitted and before being received and the sample space being configured to receive a sample support (5) for receiving the fluid substance (1); and a transformer (6) being configured to transform the received RF signal (3b) into a readable signal (7) that is sensitive to indicate the presence of the fluid substance (1) in the sample support (5) having a substance volume (V) in a range between 500µL and 0.1µL, specifically in a range between 20µL and 0.5µL.

Classes IPC  ?

• G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
• G01N 22/04 - Recherche de la teneur en eau
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
• G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang

Produits et services

(1) Diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]. (2) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes; nucleic acid sequences for medical and veterinary purposes. (1) Scientific research in the field of genetics and genetic engineering; genetic testing for scientific research purposes; scientific advisory services relating to chemical reagents; laboratory testing; biochemical research and analysis.

Abrégé

A system for managing heart disease, the system including a patient management platform for managing heart disease in patients, the patient management platform connected with one or more mobile and remote patient monitoring device(s) configured to remotely obtain patient physiological attributes outside of a clinic or hospital setting. The patient management platform is configured to receive patient data through electronic patient data systems (e g., an EMR) and compare the physiological attributes and patient data with at least one heart disease treatment protocol. Based on the analyzing, the platform determines one or more recommended action(s) to be taken according to at least one heart disease treatment protocol and generates a notification of the recommended action(s).

Classes IPC  ?

• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
• G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Produits et services

(1) Diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]. (2) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes; nucleic acid sequences for medical and veterinary purposes.

Produits et services

Chemical, biological and biochemical preparations for scientific and research purposes; in vitro diagnostic reagents for use in industry and science; chemical preparations for use in chromatography; separation materials for use in liquid chromatography columns, namely, chromatography separation media for separation of a mixture into components; chemical reagents for use with spectrometers for analyzing biological samples in the clinical diagnostic field for research purposes Chemical, biological and biochemical preparations for the analysis of biological samples for medical purposes; in vitro diagnostic reagents for the analysis of biological samples for medical purposes; in vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples for medical diagnostic purposes Laboratory instruments for laboratory use for use in preparation of biological samples, chromatography and analysis of biological samples for medical research purposes; spectrometers for laboratory use; chromatography columns for laboratory use with laboratory instruments for use in preparation of biological samples, chromatography and analysis of biological samples; downloadable computer software for laboratory use in the field of diagnostics, namely, software for storage, retrieval, and processing of mass spectrometry data; downloadable computer software for laboratory use featuring algorithms for laboratory test data analysis; downloadable computer software for laboratory use having processing algorithm used to identify, filter, analyze, visualize and manage data from biological information

Abrégé

The present disclosure refers to an in vivo analyte sensor, comprising: a substrate (20); a conductive layer (21) disposed over at least a portion of the substrate (20); a sensing layer (24) disposed formed on the conductive layer (21), wherein the sensin\g layer (24) forms a sensing area configured to generate one or more signals identifying a monitored analyte level after insertion of the analyte sensor and when maintained in fluid contact with interstitial fluid; and a membrane layer (25) formed at least on the sensing layer (24). The sensing layer (24) is formed with an area sensitivity of 0,2 to 1,5 nA/(mqx/dL) mm2 within the sensing area. Further, a method of manufacturing an in vivo analyte sensor is provided.

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

A filling lance device (40) configured for contamination-free filling of a container (20) with a substance (1), the filling lance device (40) comprising: a tubular filling lance (41) and a lance housing (46) enclosing at least partially the tubular filling lance (41), wherein the tubular filling lance (41) and the lance housing (46) are movably arranged relative to each other between at least one filling configuration (A) and at least one de-contamination configuration (B, C, D), wherein the lance housing (46) comprises a channel system (48) being fluidically connectable to an external suction pump (7) and wherein the at least one de-contamination configuration (B, C, D) corresponds to a configuration in which the channel system (48) is in fluidic connection with the tubular filling lance (41).

Classes IPC  ?

• B65B 3/00 - Emballage de matériaux plastiques, de semi-liquides, de liquides ou de liquides et solides mélangés, dans des réceptacles ou récipients individuels, p. ex. dans des sacs ou sachets, boîtes, cartons, bidons ou pots
• B65B 39/04 - Ajutages, entonnoirs ou guides pour introduire des objets ou matériaux dans les réceptacles ou les emballages avec des passages pour l'échappement ou l'évacuation de l'air
• B65B 39/12 - Ajutages, entonnoirs ou guides pour introduire des objets ou matériaux dans les réceptacles ou les emballages pouvant se rapprocher ou s'éloigner du réceptacle ou de l'emballage durant le remplissage
• F26B 5/04 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide
• F26B 5/12 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par aspiration

Abrégé

An automatic analysis device 1 comprises: a flow path 41; a first electrode 42, a second electrode 43, and a reference electrode 44 which are electrodes 48 for applying a voltage to the flow path 41; a determination unit which determines the presence/absence of an abnormality in the flow path 41 and/or the electrodes 48; and a storage unit which stores a feature amount related to a first waveform indicating the waveform of a current flowing through one of the electrodes 48 in a prescribed effective time zone Z after the start of voltage application in the case where the flow path 41 and the electrodes 48 are normal and the voltage between the first electrode 42 and the reference electrode 44 is controlled to be a prescribed voltage value. The determination unit determines the presence/absence of an abnormality in the flow path 41 and/or the electrodes 48 by comparing the feature amount related to the first waveform and a feature amount related to a second waveform indicating the waveform of a current flowing through one of the electrodes 48 in the prescribed effective time zone Z after a prescribed period of time has passed since the feature amount related to the first waveform was stored in the storage unit. As a result, the presence/absence of an abnormality in components constituting a reaction unit can be detected.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• G01N 21/69 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité électriquement, p. ex. par électroluminescence spécialement adaptés pour les fluides
• G01N 35/08 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant un courant d'échantillons discrets circulant dans une canalisation, p. ex. analyse à injection dans un écoulement

Abrégé

The present invention relates to the field of diagnostics. In particular, it relates to a computer-implemented method for assessing a medical condition in a subject comprising the steps of determining the amount of at least one biomarker of interest for said medical condition in a sample of the subject, comparing the determined amount of the at least one biomarker to a reference, and assessing the medical condition in the subject based on the comparison and improving the reliability of the said assessment by integrating at least one clinical parameter value of the medical condition obtained from a dataset of continuously determined clinical parameter values comprising the said at least one clinical parameter value into the biomarker-based assessment, wherein the sample and the at least one clinical parameter value have been obtained from the subject within a short time window, wherein said at least one biomarker is determined continuously by using a point-of-care analytical device and/or wherein the dataset comprising the at least one clinical parameter is determined by a wearable sensing device. Moreover, the invention provides a system and a device for assessing a medical condition in a subject as well as the use of the amount of at least one biomarker of interest for said medical condition in a sample of the subject or a detection agent therefor for assessing a medical condition in said subject.

Classes IPC  ?

• G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The present invention relates to a method for protecting and/or stabilizing free SH-group containing polypeptide against the inactivation thereof by an isothiazolinone type compound, comprising the step of covalently coupling at last one albumin to at least one free SH-group of the free SH-group containing polypeptide. Furthermore, the present invention relates to the stabilized free SH-group containing polypeptide, for example a biosensor, such as an enzyme used for indicating or detecting a biological state or medical parameter. The present invention also provides a method for producing a pharmaceutical composition comprising the stabilized free SH-group containing polypeptide, and a kit for use with the above-mentioned method.

Classes IPC  ?

• C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs
• C07K 14/765 - Sérum albumine, p. ex. HSA

Abrégé

A test kit (110), a test strip (112) and a method for determining analytes in a sample of a bodily fluid (111) are disclosed. The test kit (110) comprises: i) at least one test strip (112) comprising at least one membrane (114), wherein the membrane (114) comprises at least one first test field (116), the first test field (116) comprising at least one first capture component (118), wherein the membrane (114) further comprises at least one second test field (120), the second test field (120) comprising at least one second capture component (122), wherein the second capture component (122) is different from the first capture component (118); and ii) at least one first analyte detection system (124) for contacting with the sample of the bodily fluid (111), wherein the first analyte detection system (124) comprises at least one optode compound configured for receiving a first analyte suspected to be present in the sample of the bodily fluid (111), wherein the first analyte detection system (124) further comprises at least one first capture reagent; wherein the first capture component (118) is configured for capturing the first capture reagent of the first analyte detection system (124), wherein the second capture component (122) is configured for capturing at least one second capture reagent (136) from at least one second analyte detection system (126), the second capture reagent (136) being different from the first capture reagent.

Classes IPC  ?

• G01N 33/536 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/84 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des composés inorganiques ou le pH

Produits et services

Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. Bio-sensors; biochip sensors; barcode scanners; bar code printers; portable scanners; radio-frequency identification (RFID) tags; application software for cloud computing services; bags adapted for laptops; cases for tablet computers; cases for data storage devices; computer software for use in medical decision support systems; workflow management system software; software as a medical device [SaMD], downloadable; application software for mobile devices, all the aforesaid goods related to the field of in vitro diagnostics.

Abrégé

The present invention relates to a computer implemented method for data cleansing. In the method, a data pre-processing module of a first computing instance (3) obtains an at least two-dimensional un-shuffled data structure (10). The data structure (10) comprises healthcare patient data. The data structure (10) comprises data on a plurality of patient records. Each patient record comprises one or more fields wherein each field has a field type and wherein the patient records have a pre-shuffled order. The data pre-processing module of the first computing device shuffles fields of a first field type by moving fields having the first field types from one patient record to another patient record. Fields with the first field type have a post-shuffled order after the shuffling thereby creating a shuffled data structure(lO). A communications module transmits (5) the shuffled data structure (10) comprising the healthcare patient data over a communications network (7) from the first computing instance to a second computing instance.

Classes IPC  ?

• G06F 21/62 - Protection de l’accès à des données via une plate-forme, p. ex. par clés ou règles de contrôle de l’accès

Produits et services

(1) Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; biological preparations, other than for medical or veterinary purposes; biochemical preparations for scientific purposes; diagnostic reagents for scientific or research use; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; chemical preparations for scientific purposes, other than for medical or veterinary use. (2) Chemical preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; biological preparations for medical purposes.

Abrégé

A packaging element (110) for packaging medical consumables (112) is disclosed. The packaging element (110) comprises: a. at least one carrier sheet component (114) having formed therein at least one cavity (116) and having at least one rim (118) at least partially surrounding the cavity (116); b. at least one barrier (120); and c. at least one sealing sheet material (122) configured for being coupled at least partially to the rim (118) of the at least one carrier sheet component (114) and for sealing the at least one cavity (116), - wherein the at least one cavity (116) comprises at least one consumable compartment (124) for receiving the medical consumable (112) and at least one desiccant compart- ment (126) for receiving at least one desiccant (128), and - wherein the consumable compartment (124) and the desiccant compartment (126) are separated via the at least one barrier (120), the barrier (120) preventing desiccant (128) from entering the consumable compartment (124) and the barrier (120) allowing for water vapor moving from the consumable compartment (124) to the desiccant compartment (126). Further disclosed are a medical consumable kit (140), a method of manufacturing the medical consumable kit (140) and a use of the packaging element (110).

Classes IPC  ?

• A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
• A61B 5/157 - Dispositifs de prélèvement d'échantillons de sang caractérisés par des moyens intégrés pour mesurer des caractéristiques du sang
• A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
• B65D 81/26 - Adaptations pour empêcher la détérioration ou l'altération du contenuApplications au réceptacle ou au matériau d'emballage d'agents de conservation des aliments, de fongicides, d'insecticides ou de produits repoussant les animaux avec dispositifs pour évacuer ou absorber les fluides, p. ex. s'écoulant du contenuEmploi de produits empêchant la corrosion ou de dessiccateurs
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Produits et services

(1) Chemical preparations for medical purposes; biological preparations for medical purposes; biochemical preparations for medical use; in vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for in-vitro laboratory use [for medical purposes]; diagnostic biomarker reagents for medical purposes. (2) Bio-sensors; biochip sensors; barcode scanners; bar code printers; portable scanners; radio-frequency identification (RFID) tags; application software for cloud computing services; bags adapted for laptops; cases for tablet computers; cases for data storage devices; computer software for use in medical decision support systems; workflow management system software; software as a medical device [SaMD], downloadable; application software for mobile devices, all the aforesaid goods related to the field of in vitro diagnostics.

Abrégé

The present invention relates to nucleic acids coding for a protein said protein comprising a glial fibrillary acidic protein (GFAP) and a eukaryotic secretion tag, proteins comprising a GFAP and a eukaryotic secretion tag, expression constructs comprising a nucleic acid coding for a protein which comprises a GFAP and a eukaryotic secretion tag, vectors comprising the nucleic acids or expression constructs disclosed herein and eukaryotic cells comprising a nucleic acid, expression construct or vector disclosed herein. The present invention furthermore relates to methods for the production of the herein disclosed proteins. The present invention also relates to compositions comprising the herein disclosed proteins and kits comprising the herein disclosed proteins and/or compositions. Furthermore, the present invention relates to the use of the herein disclosed proteins, compositions and/or kits for calibrating a measurement system for the in vitro quantification of GFAP or a variant thereof in a sample.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion

Abrégé

The present invention relates to nucleic acids coding for a protein said protein comprising a truncated glial fibrillary acidic protein (GFAP), proteins comprising a truncated GFAP, expression constructs comprising a nucleic acid coding for a protein which comprises a truncated GFAP, vectors comprising the nucleic acids or expression constructs disclosed herein and eukaryotic cells comprising a nucleic acid, proteins, expression construct or vector disclosed herein. The present invention furthermore relates to compositions comprising the herein disclosed proteins and kits comprising the herein disclosed proteins and/or compositions. Furthermore, the present invention relates to the use of the herein disclosed proteins, compositions and/or kits for calibrating a measurement system for the in vitro quantification of GFAP or a variant thereof in a sample.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion

Abrégé

e.g.e.g. a bacteriophage) in a sample, to determine a host range of a bacteriophage of interest, and to determine a phagogram of a bacterium of interest.

Classes IPC  ?

• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique

Abrégé

The present invention relates to a method for producing higher titers and/or a higher quality of recombinant viruses and/or less or reduced impurities in virus like particle (VLP) production in respective production processes in mammalian cell lines, the method comprising the step of supplementing a suitable mammalian cell line culture media with at least one intermediate substrate of the tricarboxylic acid (TCA) cycle and optionally supplementing the suitable mammalian cell line culture media with further additives and/or further adjusting the conditions of the mammalian cell line culture media. Furthermore, the present invention relates to the balanced suitable mammalian cell line culture media and the use of this balanced suitable mammalian cell line culture media for producing higher titers and/or a higher quality of recombinant viruses and/or less or reduced impurities in virus like particle (VLP) production in respective production processes for producing higher titers and/or quality of recombinant viruses.

Classes IPC  ?

• C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci

Produits et services

Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; Chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]. Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic biomarker reagents for medical purposes; Nucleic acid sequences for medical and veterinary purposes.

Abrégé

The disclosure relates to methods for amplifying a target nucleic acid. The methods include performing an amplifying step comprising contacting the nucleic acid with a polymerase, dNTPs, one or more set of primers specific for the nucleic acid, and an amplification enhancer that is methyl paraben or a derivative thereof. Also described are kits and reaction mixtures for the amplification of a target nucleic acid in the presence of the amplification enhancer, as well as methods for enhancing nucleic acid amplification.

Classes IPC  ?

• C12Q 1/686 - Réaction en chaine par polymérase [PCR]

Produits et services

Diagnostic preparations for research laboratory use; Diagnostic reagents for scientific or research use; Diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; Calibration fluids for medical apparatus; Reagents in kit form for conducting enzyme-linked immunosorbent assays (elisa) [other than for medical or veterinary purposes]; Chemicals for use in performing nucleic acid polymerase chain reactions [other than medical and veterinary]. Chemical preparations for medical purposes; Biological preparations for medical purposes; Biochemical preparations for medical use; In vitro diagnostic preparations for medical use; Diagnostic reagents for medical use; Reagents for in-vitro laboratory use [for medical purposes]; Diagnostic biomarker reagents for medical purposes; Nucleic acid sequences for medical and veterinary purposes. Scientific research in the field of genetics and genetic engineering; Advisory services relating to chemical reagents; Laboratory testing; Biological research and analysis.

Abrégé

An autonomous mobile robot module (30) for performing multiple laboratory operations, wherein the robot module (30) comprises: a safety sensor for detecting a human; a robot module controller (30.14) configured to control the multiple laboratory operations and to stop at least one of multiple laboratory operations when the human is detected; a motor for driving a movement of the autonomous mobile robot module (30) controlled by the robot module controller (30.14); a robot platform for receiving objects; a robot arm configured for performing multiple laboratory operations controlled by the robot module controller (30.14); one or more tools being connectable to the robot arm, wherein the one or more tools comprises at least: a capper and/or decapper function for capping and/or decapping of containers; a pipetting function for pipetting liquids among the containers.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• B25J 9/16 - Commandes à programme
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
• G06N 3/08 - Méthodes d'apprentissage
• G06V 40/00 - Reconnaissance de formes biométriques, liées aux êtres humains ou aux animaux, dans les données d’image ou vidéo

Abrégé

The present invention relates to methods for assessing heart muscle tissue damage. The methods are based on the determination of the biomarker MyL7 in a sample from a subject. Moreover, the present invention relates to the use of the biomarker MyL7 (Myosin regulatory light chain 2, atrial isoform) or of at least one detection agent which specifically binds to said biomarker in at least one sample from a subject for assessing heart muscle tissue damage. The present invention further relates to a kit for assessing heart muscle tissue damage.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Ttotaltotal total , to process the biological sample by the respective laboratory, and performing a routing action related to the biological sample on the basis of the respective total times Estimating the total time is performed using a model which includes one or more complexity factors indicating a complexity of one or more analytical tests to be performed by the respective laboratory, the complexity factors being derived from historical testing data.

Classes IPC  ?

• G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
• G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient

Abrégé

Mass spectrometric method (100) for detecting an analyte in a biological sample solution comprising the steps: providing (101) a constant stream of ionized sample molecules comprising the analyte from the biological sample solution and an analyte-specific internal standard including electrospray ionization (ESI), and/or nano-electrospray ionization (nano-ESI); performing (102a) a spatial accumulation of the analyte and the analyte-specific internal standard and performing (102b) at least partially a first separation of the analyte and the analyte-specific internal standard from other components of the ionized sample molecules based on the size and/or shape of the ionized molecules; performing (103) at least partially a second separation of the analyte and the analyte-specific internal standard from remained other components of the ionized sample molecules based on the mass to charge ratio of the ionized molecules; fragmenting (104) the ionized analyte into ionized analyte fragments and the analyte-specific internal standard into ionized analyte-specific internal standard fragments by collision with particles of a gas phase; providing (105) a stream comprising the ionized analyte fragments and the ionized analyte-specific internal standard fragments on a detection mass spectrometer; and recording (106) with the detection mass spectrometer at least two pre-summed mass-resolved spectra and summing (107) the at least two pre-summed mass-resolved spectra to obtain a final mass-resolved spectrum.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• G01N 27/623 - Spectrométrie de mobilité ionique combinée à la spectrométrie de masse
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Produits et services

Chemical preparations for scientific purposes, other than for medical or veterinary use; diagnostic preparations for research laboratory use; diagnostic reagents for scientific or research use; chemical reagents for use in genetic research; chemical preparations for use in DNA analysis [other than medical]; biomolecule labeling kits comprising reagents for use in scientific research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use; diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology; calibration fluids for medical apparatus; reagents in kit form for conducting enzyme-linked immunosorbent assays (ELISA) [other than for medical or veterinary purposes]. In vitro diagnostic preparations for medical use; diagnostic reagents for medical use; reagents for use in medical genetic testing; reagents for in-vitro laboratory use [for medical purposes]; chemical preparations for use in DNA analysis [medical]; preparations for detecting genetic predispositions for medical purposes; nucleic acid sequences for medical and veterinary purposes. Scientific apparatus and instruments; laboratory instruments [other than for medical use]; instruments for diagnosis [for scientific use]; quantitative polymerase chain reaction [PCR] instruments for scientific use; real-time polymerase chain reaction [PCR] instruments for scientific use; laboratory devices for detecting genetic sequences; diagnostic apparatus for research laboratory use; DNA microarray; devices for analyzing genome information; devices for analyzing protein sequence used as laboratory apparatus; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; nucleic acid sequencers for scientific purposes; laboratory devices for detecting genetic sequences; gene amplifiers; computer software for use in medical decision support systems; workflow management system software; bioinformatics software. Testing apparatus for medical purposes; diagnostic apparatus for medical purposes; real-time polymerase chain reaction [PCR] instruments for medical use; diagnostic testing instruments for use in immunoassay procedure [medical]; immunochemical medical diagnostic testing apparatus for detecting and measuring antibody levels; apparatus for DNA and RNA testing for medical purposes; apparatus for analysing substances [for medical use]; diagnostic apparatus for medical purposes used in medical laboratories; genetic testing apparatus for medical purposes. Research in the field of DNA mutation; DNA screening for scientific research purposes; laboratory research in the field of gene expression; consultancy relating to laboratory testing; medical research; research and development in the field of diagnostic preparations; providing temporary use of on-line non-downloadable operating software for accessing and using a cloud computing network; information on the subject of scientific research in the field of biochemistry and biotechnology; software as a service [SaaS].

Abrégé

A sampling device (110) for sampling bodily fluid is proposed, comprising a stationary component (118) and a movable component (120) being movably mounted to the stationary component (118). The movable component (120) is movable from at least one distal position to at least one proximal position and back. The movable component (120) comprises at least one penetration element (132) for penetrating the skin of a user, which, in the distal position of the movable component (120), is received within the stationary component (118) and which, in the proximal position of the movable component (120), protrudes from an application side (128) of the stationary component (118). The movable component (120) comprises a container receptacle (134) for receiving at least one sample container (114) having a septum (136). The sampling device (110) further comprises a sample collection channel (138) for transporting sample from the application side (128) into the container receptacle (134). The sampling device (110) further comprises a pressure chamber (140) having a volume being dependent on the position of the movable component (120), wherein the volume when the movable component (120) is in the proximal position is smaller than the volume when the movable component (120) is in the distal position. The sampling device (110) further comprises a pressure adjustment channel (154) for transferring underpressure from the pressure chamber (140) into the sample container (114) through the septum (136) when the movable component (120) is retracted from the proximal position into the distal position. Further, a sampling kit (112) for sampling bodily fluid and a method for generating an underpressure in a sample container (114) having a septum (136) are proposed.

Classes IPC  ?

• A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
• A61B 5/151 - Dispositifs de prélèvement d'échantillons de sang spécialement adaptés pour le prélèvement d'échantillons de sang capillaire, p. ex. par des lancettes

Produits et services

Bio-sensors; biochip sensors; barcode readers; bar code printers; portable scanners; radio-frequency identification (RFID) tags; interfaces for computers; electronic docking stations; application software for cloud computing services; cases for tablet computers; cases for data storage devices; computer software relating to the medical field; computer software for use in medical decision support systems; workflow management system software; software as a medical device [SaMD], downloadable; application software for mobile devices.

Produits et services

Chemical, biochemical and biological preparations for scientific and research purposes, namely, diagnostic and detection reagents for scientific and research purposes; chemical reagents for research or laboratory use, other than for medical or veterinary use; chemical reagents for the preparation and staining of tissue specimens for research purposes; chemical reagents for non-medical purposes, namely, for use in histological and cytological tissue processing Chemical, biochemical and biological preparations for medical purposes, namely, diagnostic and detection reagents for medical use; in vitro diagnostic reagents for medical use; histology and cytology reagents and staining dyes for preparation and staining of tissue specimens for medical purposes; diagnostic reagents for medical use in the fields of pathology, immunohistochemistry and in situ-hybridization Scientific apparatus, equipment and instruments for performing analyses in laboratories, namely, automated slide staining apparatus for treating and staining tissue slide specimens for laboratory or research use; laboratory equipment, namely, automated sample handling equipment for treating and staining tissue slide specimens for diagnostic use for laboratory or research use; automated laboratory instruments, namely, slide scanners, digital imaging apparatus, microscopes and computer systems comprised of computer hardware and downloadable computer software, all for staining and visualization of tissue or cell based samples for research and scientific use; downloadable computer software for medical and diagnostic purposes, namely, for diagnosing medical disorders; downloadable computer software for the provision of automated diagnostic laboratory processes; downloadable computer software for use with laboratory instruments, namely, for use in providing remote automated control, connection, data analysis, and data management; computer systems comprised of computer hardware and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes; downloadable bioinformatics-enabled medical diagnosis software Medical apparatus and instruments for medical purposes, namely, automated slide staining apparatus for treating and staining tissue specimens for cancer and other tissue-based medical diagnostic testing; diagnostic apparatus for medical purposes, namely, sample preparation device for cancer and other tissue-based medical diagnostic testing; medical apparatus for performing in-vitro diagnostic tests for cancer and other tissue-based diseases; automated slide preparation and staining apparatus for use with tissue slide specimens for medical diagnostic use; medical apparatus and instruments for performing histological and cytological tissue processing and staining for diagnostic purposes