The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.
C07K 4/12 - Peptides having up to 20 amino acids in an undefined or only partially defined sequenceDerivatives thereof from animalsPeptides having up to 20 amino acids in an undefined or only partially defined sequenceDerivatives thereof from humans
C07K 1/02 - General processes for the preparation of peptides in solution
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for use in the research, development,
and manufacture of dental materials, namely, dental
restoration materials; chemical additives for use in the
manufacture of dental preparations; proteins for use in
manufacture; proteins for use in the manufacture of dental
restoration materials and dental preparations; chemicals for
use in biotechnological product development. Dental compounds, namely, dental restoration compounds;
materials for tooth restoration; dental composite materials;
lining materials for dental purposes; mineralizing dental
materials, namely, materials for the treatment and
management of tooth decay; dental compounds for topical
application that form enamel-like properties on teeth. Medical research and development of mineralization
technologies for the management of chronic dental diseases,
as well as diseases and conditions that arise from dental
and oral health complications; biochemical research and
development; custom design and development of chemical
reagents; research and development in the field of medical
preparations; research and development of coatings or
finishes that strengthen or improve the resistance to
environmental conditions of materials.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations for use in the research, development,
and manufacture of dental materials, namely, dental
restoration materials; chemical additives for use in the
manufacture of dental preparations; proteins for use in
manufacture; proteins for use in the manufacture of dental
restoration materials and dental preparations; chemicals for
use in biotechnological product development. Dental compounds, namely, dental restoration compounds;
materials for tooth restoration; dental composite materials;
lining materials for dental purposes; mineralizing dental
materials, namely, materials for the treatment and
management of tooth decay; dental compounds for topical
application that form enamel-like properties on teeth.
4.
SUBSTRATES COMPRISING ELASTIN-LIKE POLYPEPTIDES AND CALCIUM IONS
The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations for use in the research, development,
and manufacture of dental materials, namely, dental
restoration materials; chemical additives for use in the
manufacture of dental preparations; proteins for use in
manufacture; proteins for use in the manufacture of dental
restoration materials and dental preparations; chemicals for
use in biotechnological product development. Dental compounds, namely, dental restoration compounds;
materials for tooth restoration; dental composite materials;
lining materials for dental purposes; mineralizing dental
materials, namely, materials for the treatment and
management of tooth decay; dental compounds for topical
application that form enamel-like properties on teeth.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for use in the research, development,
and manufacture of dental materials, namely, dental
restoration materials; chemical additives for use in the
manufacture of dental preparations; proteins for use in
manufacture; proteins for use in the manufacture of dental
restoration materials and dental preparations; chemicals for
use in biotechnological product development. Dental compounds, namely, dental restoration compounds;
materials for tooth restoration; dental composite materials;
lining materials for dental purposes; mineralizing dental
materials, namely, materials for the treatment and
management of tooth decay; dental compounds for topical
application that form enamel-like properties on teeth. Medical research and development of mineralization
technologies for the management of chronic dental diseases,
as well as diseases and conditions that arise from dental
and oral health complications; biochemical research and
development; custom design and development of chemical
reagents; research and development in the field of medical
preparations; research and development of coatings or
finishes that strengthen or improve the resistance to
environmental conditions of materials.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for use in the research, development,
and manufacture of dental materials, namely, dental
restoration materials; chemical additives for use in the
manufacture of dental preparations; proteins for use in
manufacture; proteins for use in the manufacture of dental
restoration materials and dental preparations; chemicals for
use in biotechnological product development. Dental compounds, namely, dental restoration compounds;
materials for tooth restoration; dental composite materials;
lining materials for dental purposes; mineralizing dental
materials, namely, materials for the treatment and
management of tooth decay; dental compounds for topical
application that form enamel-like properties on teeth. Medical research and development of mineralization
technologies for the management of chronic dental diseases,
as well as diseases and conditions that arise from dental
and oral health complications; biochemical research and
development; custom design and development of chemical
reagents; research and development in the field of medical
preparations; research and development of coatings or
finishes that strengthen or improve the resistance to
environmental conditions of materials.
The present invention relates to new biomimetic mineralized apatite structures. The present invention also relates to processes for the production of new biomimetic mineralized apatite structures based on natural and synthetic protein scaffolds. In particular, the invention provides synthetic crystal having a hierarchical structure formed on an elastin-like polypeptide membrane or hydrogel. The invention also provides methods of making such crystals, both in vivo and in vitro, as well as kits comprising membranes or hydrogels with cross-linking agents and/or mineralization solutions. The invention also provides the use of such structures in methods of treatment.
The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C30B 7/04 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent using aqueous solvents
10.
SUBSTRATES COMPRISING ELASTIN-LIKE POLYPEPTIDES AND CALCIUM IONS
The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth Medical research and development new technology for others in the field of dental mineralization, for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and product development; custom product design and development in the field of chemical reagents; research and development in the field of medical preparations; research and development of new products in the nature of coatings and finishes that strengthen or improve the resistance to environmental conditions of materials
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth Medical research and development new technology for others in the field of dental mineralization, for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and product development; custom product design and development in the field of chemical reagents; research and development in the field of medical preparations; research and development of new products in the nature of coatings and finishes that strengthen or improve the resistance to environmental conditions of materials
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth Medical research and development new technology for others in the field of dental mineralization, for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and product development; custom product design and development in the field of chemical reagents; research and development in the field of medical preparations; research and development of new products in the nature of coatings and finishes that strengthen or improve the resistance to environmental conditions of materials
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth
The present invention relates to new biomimetic mineralized apatite structures. The present invention also relates to processes for the production of new biomimetic mineralized apatite structures based on natural and synthetic protein scaffolds. In particular, the invention provides synthetic crystal having a hierarchical structure formed on an elastin-like polypeptide membrane or hydrogel. The invention also provides methods of making such crystals, both in vivo and in vitro, as well as kits comprising membranes or hydrogels with cross-linking agents and/or mineralization solutions. The invention also provides the use of such structures in methods of treatment.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C30B 7/04 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent using aqueous solvents
