Abrégé

The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.

Classes IPC  ?

• C07K 4/12 - Peptides ayant jusqu'à 20 amino-acides dans une séquence indéterminée ou partiellement déterminéeLeurs dérivés provenant d'animauxPeptides ayant jusqu'à 20 amino-acides dans une séquence indéterminée ou partiellement déterminéeLeurs dérivés provenant d'humains
• C07K 1/02 - Procédés généraux de préparation de peptides en solution
• C30B 29/58 - Composés macromoléculaires

Produits et services

Chemical preparations for use in the research, development, and manufacture of dental materials, namely, dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development. Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, materials for the treatment and management of tooth decay; dental compounds for topical application that form enamel-like properties on teeth. Medical research and development of mineralization technologies for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and development; custom design and development of chemical reagents; research and development in the field of medical preparations; research and development of coatings or finishes that strengthen or improve the resistance to environmental conditions of materials.

Produits et services

Chemical preparations for use in the research, development, and manufacture of dental materials, namely, dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development. Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, materials for the treatment and management of tooth decay; dental compounds for topical application that form enamel-like properties on teeth.

Abrégé

The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
• A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
• C30B 29/58 - Composés macromoléculaires

Produits et services

Chemical preparations for use in the research, development, and manufacture of dental materials, namely, dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development. Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, materials for the treatment and management of tooth decay; dental compounds for topical application that form enamel-like properties on teeth.

Produits et services

Chemical preparations for use in the research, development, and manufacture of dental materials, namely, dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development. Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, materials for the treatment and management of tooth decay; dental compounds for topical application that form enamel-like properties on teeth. Medical research and development of mineralization technologies for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and development; custom design and development of chemical reagents; research and development in the field of medical preparations; research and development of coatings or finishes that strengthen or improve the resistance to environmental conditions of materials.

Produits et services

Chemical preparations for use in the research, development, and manufacture of dental materials, namely, dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development. Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, materials for the treatment and management of tooth decay; dental compounds for topical application that form enamel-like properties on teeth. Medical research and development of mineralization technologies for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and development; custom design and development of chemical reagents; research and development in the field of medical preparations; research and development of coatings or finishes that strengthen or improve the resistance to environmental conditions of materials.

Abrégé

The present invention relates to new biomimetic mineralized apatite structures. The present invention also relates to processes for the production of new biomimetic mineralized apatite structures based on natural and synthetic protein scaffolds. In particular, the invention provides synthetic crystal having a hierarchical structure formed on an elastin-like polypeptide membrane or hydrogel. The invention also provides methods of making such crystals, both in vivo and in vitro, as well as kits comprising membranes or hydrogels with cross-linking agents and/or mineralization solutions. The invention also provides the use of such structures in methods of treatment.

Classes IPC  ?

• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61K 6/60 - Préparations pour la technique dentaire comprenant des additifs organiques ou organométalliques
• A61K 6/838 - Composés du phosphore, p. ex. apatite
• A61L 27/22 - Polypeptides ou leurs dérivés

Abrégé

The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.

Classes IPC  ?

• C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
• C30B 7/04 - Croissance des monocristaux à partir de solutions en utilisant des solvants liquides à la température ordinaire, p. ex. à partir de solutions aqueuses par évaporation du solvant en utilisant des solvants aqueux

Abrégé

The disclosure is directed towards polypeptide substrates and methods of synthesis thereof. Such substrates can be embedded with calcium ions from a number of ionic sources. These calcium-embedded, polypeptide substrates can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures. As such, the disclosure is additionally directed towards methods of crystal growth from polypeptide substrates. Compositions of the disclosure can be used in a wide variety of medical and other applications.

Classes IPC  ?

• A61L 27/22 - Polypeptides ou leurs dérivés
• A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 27/58 - Matériaux au moins partiellement résorbables par le corps

Produits et services

Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth Medical research and development new technology for others in the field of dental mineralization, for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and product development; custom product design and development in the field of chemical reagents; research and development in the field of medical preparations; research and development of new products in the nature of coatings and finishes that strengthen or improve the resistance to environmental conditions of materials

Produits et services

Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth Medical research and development new technology for others in the field of dental mineralization, for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and product development; custom product design and development in the field of chemical reagents; research and development in the field of medical preparations; research and development of new products in the nature of coatings and finishes that strengthen or improve the resistance to environmental conditions of materials

Produits et services

Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth

Produits et services

Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth Medical research and development new technology for others in the field of dental mineralization, for the management of chronic dental diseases, as well as diseases and conditions that arise from dental and oral health complications; biochemical research and product development; custom product design and development in the field of chemical reagents; research and development in the field of medical preparations; research and development of new products in the nature of coatings and finishes that strengthen or improve the resistance to environmental conditions of materials

Produits et services

Chemical preparations for use in the manufacture of dental restoration materials; chemical preparations for scientific purposes, for use in the research and development of dental restoration materials; chemical additives for use in the manufacture of dental preparations; proteins for use in manufacture; proteins for use in the manufacture of dental restoration materials and dental preparations; chemicals for use in biotechnological product development Dental compounds, namely, dental restoration compounds; materials for tooth restoration; dental composite materials; lining materials for dental purposes; mineralizing dental materials, namely, dental composite materials for the treatment and management of tooth decay; dental restoration compounds for topical application that form enamel-like properties on teeth

Abrégé

The present invention relates to new biomimetic mineralized apatite structures. The present invention also relates to processes for the production of new biomimetic mineralized apatite structures based on natural and synthetic protein scaffolds. In particular, the invention provides synthetic crystal having a hierarchical structure formed on an elastin-like polypeptide membrane or hydrogel. The invention also provides methods of making such crystals, both in vivo and in vitro, as well as kits comprising membranes or hydrogels with cross-linking agents and/or mineralization solutions. The invention also provides the use of such structures in methods of treatment.

Classes IPC  ?

• C30B 29/14 - Phosphates
• C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
• C30B 7/04 - Croissance des monocristaux à partir de solutions en utilisant des solvants liquides à la température ordinaire, p. ex. à partir de solutions aqueuses par évaporation du solvant en utilisant des solvants aqueux
• C30B 29/58 - Composés macromoléculaires
• A61K 38/00 - Préparations médicinales contenant des peptides