Data encodable polymers, including nucleic polymers, for data storage and related methods are described. Generally, a nucleic acid polymer can have chemically modifiable structures iteratively repeated along the polymer. The chemically modifiable structures can be modified to encode data. A data encoding device can have a spatial resolution that modifies a string of contiguous chemically modifiable structures to yield a cluster of modified structures. Various methods can be utilized to generate a data encodable nucleic acid polymer. Various methods can be utilized to encode a data encodable nucleic acid polymer. Various methods of decoding can be utilized to decode an encoded nucleic acid or other polymer.
Provided herein are compositions and methods related to polymers comprising a plurality of subunits, wherein a first subunit of the comprises more than one convertible residue, a second subunit does not comprise a convertible residue and each subunit comprises at least 30 residues.
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
G06N 99/00 - Subject matter not provided for in other groups of this subclass
G11C 11/56 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using storage elements with more than two stable states represented by steps, e.g. of voltage, current, phase, frequency
3.
COMPOSITIONS, SYSTEMS, AND METHODS FOR DATA STORAGE USING NUCLEIC ACIDS AND POLYMERASES
Nucleic acid polymers for data storage and related methods are provided. In some embodiments, the nucleic acid polymers are writable for data, and in other embodiments, the nucleic acid polymers are encoded with data when synthesized. Generally, a writable polymer may contain one or more convertible residues (e.g., chemically alterable group) bits that are enabled to provide a data code. Various methods can be utilized to generate a writable nucleic acid polymer, or a data encoded nucleic acid polymer. Various methods can be utilized to encode a nucleic acid polymer by selectively modifying convertible residues via a light or redox source with an enzyme (e.g., polymerase) conjugated to a sensitizer. Various methods of reading an encoded nucleic acid polymer are also described herein.
Provided herein are writable polymers (e.g., writable nucleic acid polymers) for data storage and related methods. Generally, a writable polymer (e.g., a nucleic acid polymer) contains one or more convertible residues (e.g., convertible nucleobases) that are capable of being converted from a first state to a second state, the first and the second state being different. Various methods can be utilized to generate a writable nucleic polymer, such as polymerase extension via rolling circle reaction or chemical synthesis and ligation. Also provided herein are various methods for writing or encoding a writable nucleic acid polymer by selectively converting nucleobases into the second state. Also provided herein are various methods for reading or decoding a nucleic acid polymer encoded with data.
Described herein are writable polymers for data storage and related methods. Generally, a writable polymer may contain one or more convertible residues (e.g., convertible residues comprising a modifiable fluorophore with switchable fluorescent states) that are enabled to provide a data code. Various methods can be utilized to generate a writable polymer (e.g., a writable nucleic polymer). Various methods can be utilized to encode a writable polymer by selectively modifying the one or more convertible residues (e.g., modifiable fluorophores). Various methods of reading a polymer encoded with data are also described herein.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C07H 99/00 - Subject matter not provided for in other groups of this subclass
6.
COMPOSITIONS, SYSTEMS, AND METHODS FOR NUCLEIC ACID DATA STORAGE
Described herein are writable polymers for data storage and related methods. Generally, a writable polymer may contain one or more convertible residues (e.g., convertible residues comprising a modifiable fluorophore with switchable fluorescent states) that are enabled to provide a data code. Various methods can be utilized to generate a writable polymer (e.g., a writable nucleic polymer). Various methods can be utilized to encode a writable polymer by selectively modifying the one or more convertible residues (e.g., modifiable fluorophores). Various methods of reading a polymer encoded with data are also described herein.
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
G11C 13/02 - Digital stores characterised by the use of storage elements not covered by groups , , or using elements whose operation depends upon chemical change
G11C 13/04 - Digital stores characterised by the use of storage elements not covered by groups , , or using optical elements
7.
COMPOSITIONS, SYSTEMS, AND METHODS FOR DATA STORAGE BY MODIFYING AND READING CLUSTERS OF CONVERTIBLE MONOMERS IN POLYMERS
Data encodable polymers, including nucleic polymers, for data storage and related methods are described. Generally, a nucleic acid polymer can have chemically modifiable structures iteratively repeated along the polymer. The chemically modifiable structures can be modified to encode data. A data encoding device can have a spatial resolution that modifies a string of contiguous chemically modifiable structures to yield a cluster of modified structures. Various methods can be utilized to generate a data encodable nucleic acid polymer. Various methods can be utilized to encode a data encodable nucleic acid polymer. Various methods of decoding can be utilized to decode an encoded nucleic acid or other polymer.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Data encodable polymers, including nucleic polymers, for data storage and related methods are described. Generally, a nucleic acid polymer can have chemically modifiable structures iteratively repeated along the polymer. The chemically modifiable structures can be modified to encode data. A data encoding device can have a spatial resolution that modifies a string of contiguous chemically modifiable structures to yield a cluster of modified structures. Various methods can be utilized to generate a data encodable nucleic acid polymer. Various methods can be utilized to encode a data encodable nucleic acid polymer. Various methods of decoding can be utilized to decode an encoded nucleic acid or other polymer.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
Nucleic acid polymers for data storage and related methods are provided. In some embodiments, the nucleic acid polymers are writable for data, and in other embodiments, the nucleic acid polymers are encoded with data when synthesized. Generally, a writable polymer may contain one or more convertible residues (e.g., chemically alterable group) bits that are enabled to provide a data code. Various methods can be utilized to generate a writable nucleic acid polymer, or a data encoded nucleic acid polymer. Various methods can be utilized to encode a nucleic acid polymer by selectively modifying convertible residues via a light or redox source with an enzyme (e.g., polymerase) conjugated to a sensitizer. Various methods of reading an encoded nucleic acid polymer are also described herein.
C09B 57/10 - Metal complexes of organic compounds not being dyes in uncomplexed form
G11C 11/56 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using storage elements with more than two stable states represented by steps, e.g. of voltage, current, phase, frequency
G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
10.
COMPOSITIONS, SYSTEMS, AND METHODS FOR NUCLEIC ACID DATA STORAGE
Described herein are writable polymers for data storage and related methods. Generally, a writable polymer may contain one or more convertible residues (e.g., convertible residues comprising a modifiable fluorophore with switchable fluorescent states) that are enabled to provide a data code. Various methods can be utilized to generate a writable polymer (e.g., a writable nucleic polymer). Various methods can be utilized to encode a writable polymer by selectively modifying the one or more convertible residues (e.g., modifiable fluorophores). Various methods of reading a polymer encoded with data are also described herein.
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
G11C 11/56 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using storage elements with more than two stable states represented by steps, e.g. of voltage, current, phase, frequency
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
11.
COMPOSITIONS, SYSTEMS, AND METHODS FOR NUCLEIC ACID DATA STORAGE
Provided herein are writable polymers (e.g., writable nucleic acid polymers) for data storage and related methods. Generally, a writable polymer (e.g., a nucleic acid polymer) contains one or more convertible residues (e.g., convertible nucleobases) that are capable of being converted from a first state to a second state, the first and the second state being different. Various methods can be utilized to generate a writable nucleic polymer, such as polymerase extension via rolling circle reaction or chemical synthesis and ligation. Also provided herein are various methods for writing or encoding a writable nucleic acid polymer by selectively converting nucleobases into the second state. Also provided herein are various methods for reading or decoding a nucleic acid polymer encoded with data.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
patents
