Data encodable polymers, including nucleic polymers, for data storage and related methods are described. Generally, a nucleic acid polymer can have chemically modifiable structures iteratively repeated along the polymer. The chemically modifiable structures can be modified to encode data. A data encoding device can have a spatial resolution that modifies a string of contiguous chemically modifiable structures to yield a cluster of modified structures. Various methods can be utilized to generate a data encodable nucleic acid polymer. Various methods can be utilized to encode a data encodable nucleic acid polymer. Various methods of decoding can be utilized to decode an encoded nucleic acid or other polymer.
Provided herein are compositions and methods related to polymers comprising a plurality of subunits, wherein a first subunit of the comprises more than one convertible residue, a second subunit does not comprise a convertible residue and each subunit comprises at least 30 residues.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G06N 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
G11C 11/56 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments d'emmagasinage comportant plus de deux états stables représentés par des échelons, p. ex. de tension, de courant, de phase, de fréquence
3.
COMPOSITIONS, SYSTEMS, AND METHODS FOR DATA STORAGE USING NUCLEIC ACIDS AND POLYMERASES
Nucleic acid polymers for data storage and related methods are provided. In some embodiments, the nucleic acid polymers are writable for data, and in other embodiments, the nucleic acid polymers are encoded with data when synthesized. Generally, a writable polymer may contain one or more convertible residues (e.g., chemically alterable group) bits that are enabled to provide a data code. Various methods can be utilized to generate a writable nucleic acid polymer, or a data encoded nucleic acid polymer. Various methods can be utilized to encode a nucleic acid polymer by selectively modifying convertible residues via a light or redox source with an enzyme (e.g., polymerase) conjugated to a sensitizer. Various methods of reading an encoded nucleic acid polymer are also described herein.
Provided herein are writable polymers (e.g., writable nucleic acid polymers) for data storage and related methods. Generally, a writable polymer (e.g., a nucleic acid polymer) contains one or more convertible residues (e.g., convertible nucleobases) that are capable of being converted from a first state to a second state, the first and the second state being different. Various methods can be utilized to generate a writable nucleic polymer, such as polymerase extension via rolling circle reaction or chemical synthesis and ligation. Also provided herein are various methods for writing or encoding a writable nucleic acid polymer by selectively converting nucleobases into the second state. Also provided herein are various methods for reading or decoding a nucleic acid polymer encoded with data.
Described herein are writable polymers for data storage and related methods. Generally, a writable polymer may contain one or more convertible residues (e.g., convertible residues comprising a modifiable fluorophore with switchable fluorescent states) that are enabled to provide a data code. Various methods can be utilized to generate a writable polymer (e.g., a writable nucleic polymer). Various methods can be utilized to encode a writable polymer by selectively modifying the one or more convertible residues (e.g., modifiable fluorophores). Various methods of reading a polymer encoded with data are also described herein.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C07H 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
6.
COMPOSITIONS, SYSTEMS, AND METHODS FOR NUCLEIC ACID DATA STORAGE
Described herein are writable polymers for data storage and related methods. Generally, a writable polymer may contain one or more convertible residues (e.g., convertible residues comprising a modifiable fluorophore with switchable fluorescent states) that are enabled to provide a data code. Various methods can be utilized to generate a writable polymer (e.g., a writable nucleic polymer). Various methods can be utilized to encode a writable polymer by selectively modifying the one or more convertible residues (e.g., modifiable fluorophores). Various methods of reading a polymer encoded with data are also described herein.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
G11C 13/02 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments dont le fonctionnement dépend d'un changement chimique
G11C 13/04 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments optiques
7.
COMPOSITIONS, SYSTEMS, AND METHODS FOR DATA STORAGE BY MODIFYING AND READING CLUSTERS OF CONVERTIBLE MONOMERS IN POLYMERS
Data encodable polymers, including nucleic polymers, for data storage and related methods are described. Generally, a nucleic acid polymer can have chemically modifiable structures iteratively repeated along the polymer. The chemically modifiable structures can be modified to encode data. A data encoding device can have a spatial resolution that modifies a string of contiguous chemically modifiable structures to yield a cluster of modified structures. Various methods can be utilized to generate a data encodable nucleic acid polymer. Various methods can be utilized to encode a data encodable nucleic acid polymer. Various methods of decoding can be utilized to decode an encoded nucleic acid or other polymer.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
Nucleic acid polymers for data storage and related methods are provided. In some embodiments, the nucleic acid polymers are writable for data, and in other embodiments, the nucleic acid polymers are encoded with data when synthesized. Generally, a writable polymer may contain one or more convertible residues (e.g., chemically alterable group) bits that are enabled to provide a data code. Various methods can be utilized to generate a writable nucleic acid polymer, or a data encoded nucleic acid polymer. Various methods can be utilized to encode a nucleic acid polymer by selectively modifying convertible residues via a light or redox source with an enzyme (e.g., polymerase) conjugated to a sensitizer. Various methods of reading an encoded nucleic acid polymer are also described herein.
C09B 57/10 - Complexes métalliques de composés organiques qui ne sont pas des colorants sous la forme non complexée
G11C 11/56 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments d'emmagasinage comportant plus de deux états stables représentés par des échelons, p. ex. de tension, de courant, de phase, de fréquence
G11C 13/00 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
9.
COMPOSITIONS, SYSTEMS, AND METHODS FOR NUCLEIC ACID DATA STORAGE
Described herein are writable polymers for data storage and related methods. Generally, a writable polymer may contain one or more convertible residues (e.g., convertible residues comprising a modifiable fluorophore with switchable fluorescent states) that are enabled to provide a data code. Various methods can be utilized to generate a writable polymer (e.g., a writable nucleic polymer). Various methods can be utilized to encode a writable polymer by selectively modifying the one or more convertible residues (e.g., modifiable fluorophores). Various methods of reading a polymer encoded with data are also described herein.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G11C 13/00 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou
G11C 11/56 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments d'emmagasinage comportant plus de deux états stables représentés par des échelons, p. ex. de tension, de courant, de phase, de fréquence
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
10.
COMPOSITIONS, SYSTEMS, AND METHODS FOR NUCLEIC ACID DATA STORAGE
Provided herein are writable polymers (e.g., writable nucleic acid polymers) for data storage and related methods. Generally, a writable polymer (e.g., a nucleic acid polymer) contains one or more convertible residues (e.g., convertible nucleobases) that are capable of being converted from a first state to a second state, the first and the second state being different. Various methods can be utilized to generate a writable nucleic polymer, such as polymerase extension via rolling circle reaction or chemical synthesis and ligation. Also provided herein are various methods for writing or encoding a writable nucleic acid polymer by selectively converting nucleobases into the second state. Also provided herein are various methods for reading or decoding a nucleic acid polymer encoded with data.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
G11C 13/00 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou
brevets
