Described is an optimal-control system and method provide an efficient routine for differentiating the most general Unitary, Liouville, or Monte-Carlo Schrödinger equation associated with the control problem of interest.
Described is a high-temperature superconductor (HTS) cable, comprising a plurality of HTS tapes, wherein all or part of a cross-section of at least one of the HTS tapes are removed to reduce the current carrying capacity of the HTS tape. Also described is a method for shaping the current density of a high-temperature superconductor (HTS) cable, wherein the HTS current density is carried by HTS tapes, and wherein the method comprises selective mechanical removal of all or part of the cross section of one or more of HTS tapes.
The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
Green, Alexander
Braff, Dana
Takahashi, Melissa
Pardee, Keith
Collins, James J.
Lambert, Guillaume
Ferrante, Thomas
Abstract
Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
C12Q 1/6816 - Hybridisation assays characterised by the detection means
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
5.
CORYNEBACTERIUM TO TREAT OR LIMIT CUTANEOUS WOUND INFECTION
Methods and compositions for treating a cutaneous wound to treat or limit development of a pathogenic bacterial infection are provided, involving administering to a subject having a cutaneous wound an amount effective of Corynebacteria spp., or a disclosed, composition, to treat or limit development of pathogenic bacterial infection of the wound.
A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
A61K 31/7004 - Monosaccharides having only carbon, hydrogen and oxygen atoms
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Femto-satellites are very small satellites that can be deployed in constellations from a larger mothership satellite for distributed measurement. They are too small to accommodate the GNSS receivers that many satellites use for navigation, but they can be located with an electromagnetic beam from the mothership satellite. The mothership satellite scans this beam across a constellation of femto-satellites. When the beam scans across a particular femto-satellite, the femto-satellite transmits an acknowledgement to the mothership satellite, e.g., by retroreflecting the beam or via a separate radio link. The beam can be modulated with commands for the femto-satellite, such as to make a measurement or transmit previously acquired data, as well with commands for determining the femto-satellite's location, such as a time stamp or beam pointing information. The femto-satellite can determine its location from the information modulated onto the beam or transmit the time stamp to the mothership satellite for localization.
B64G 3/00 - Observing or tracking cosmonautic vehicles
B64G 1/10 - Artificial satellitesSystems of such satellitesInterplanetary vehicles
B64G 1/44 - Arrangements or adaptations of power supply systems using radiation, e.g. deployable solar arrays
G01S 1/70 - Beacons or beacon systems transmitting signals having a characteristic or characteristics capable of being detected by non-directional receivers and defining directions, positions, or position lines fixed relatively to the beacon transmittersReceivers co-operating therewith using electromagnetic waves other than radio waves
G01S 5/16 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using electromagnetic waves other than radio waves
G01S 17/74 - Systems using reradiation of electromagnetic waves other than radio waves, e.g. IFF, i.e. identification of friend or foe
7.
COMPOSITIONS AND METHODS FOR COVALENT PEPTIDE-BASED MODULATORS OF HLA-E
This disclosure relates to synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E, methods of making such peptides, peptidomimetics, and complexes, and methods of using such peptides, peptidomimetics and complexes for blocking, inhibiting, or preventing the interaction of HLA-E with CD94/NKG2A or activation of CD94/NKG2A by HLA-E. The synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E can further comprise warheads to introduce covalent linkages between the synthetic peptides and peptidomimetics with HLA-E.
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A sequence-to-fixed-length transformation is used to process a sequence representation of a molecule structure to yield a fixed-length representation. A transformation of the fixed-length representation yields a prediction of one or more properties of the molecular structure. For example, the molecular structure is a candidate drug and the process described above is part of a screening procedure.
Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more LTR retroelement polypeptides for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more LTR retroelement polypeptides for forming a delivery vesicle may comprise two or more of an LTR retroelement gag protein, a retroelement envelope protein, an LTR retroelement reverse transcriptase, or a combination thereof. The LTR retroelement polypeptide alone, the LTR retroelement envelope protein alone, or both the LTR retroelement-derived polypeptide and LTR retroelement envelope protein may be endogenous.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (USA)
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
Barrett, Christopher, D.
Yaffe, Michael, B.
Abstract
Compositions and methods for increasing intrapleural fibrinolysis and inhibiting, treating, and/or preventing pleural space infections and/or hemothorax are disclosed.
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
Systems and methods of controlling a robot are described. In some embodiments, a method includes obtaining an input motion trajectory defining movements of the robot to perform a task and input speech corresponding with descriptions of the task. A control signal is provided to control movement of the robot based on the input motion trajectory to interact with an environment surrounding the robot with an end effector of the robot. Feedback information about the end effector resulting from the control signal is obtained, and output speech is generated by modulating the input speech based on the feedback information about the end effector.
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Xu, Qian
Chen, Gang
Liu, Weishu
Deng, Biao
Zhang, Pengxiang
Abstract
The present disclosure generally relates to high-performance flexible thermoelectric generators (f-TEGs) for heat concentration and dissipation. In some embodiments, the f-TEGs can be incorporated into wearable devices. The f-TEG device can include an f-TEG network of thermoelectric units that include multifunctional thin copper disks that can be used as electrodes, heat concentrators and spreaders, spacers, and flexibility enablers. Each electrode can include a spacer extending therefrom to suppress the heat loss between the hot and the cold sides through conduction and convection across a thermoelectric pillar disposed therebetween. In some embodiments, the f-TEG network can be associated with a fabric to provide good wearability and comfort even in wet thermal environments.
H10N 10/17 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the structure or configuration of the cell or thermocouple forming the device
14.
RATE OF PENETRATION/DEPTH MONITOR FOR A BOREHOLE FORMED WITH MILLIMETER-WAVE BEAM
Apparatus and methods are described for drilling deep boreholes with millimeter-wave radiation in earthen materials to access deep resources such as geothermal heat. Borehole depth and temperature at the bottom of the borehole can be monitored with probe signals and/or radiative emission from the bottom of the borehole.
E21B 47/135 - Means for transmitting measuring-signals or control signals from the well to the surface, or from the surface to the well, e.g. for logging while drilling by electromagnetic energy, e.g. of radio frequency range using light waves, e.g. infrared or ultraviolet waves
E21B 7/15 - Drilling by use of heat, e.g. flame drilling of electrically generated heat
E21B 45/00 - Measuring the drilling time or rate of penetration
E21B 47/022 - Determining slope or direction of the borehole, e.g. using geomagnetism
G01S 13/10 - Systems for measuring distance only using transmission of interrupted, pulse modulated waves
G01S 13/32 - Systems for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated
15.
INGESTIBLE CHEMICAL ENERGY HARVESTING SYSTEM WITH EXTENDED LIFETIME
A device is configured to be administered via an oral route by a subject. The device includes an anode, a seal disposed on the anode, and a cathode. When exposed to a liquid or a hydrogel, an exposed surface of the anode undergoes galvanic oxidation dissolution to provide DC power to the device. As the exposed surface of the anode undergoes galvanic oxidation dissolution, the seal incrementally detaches from the anode, and a substantially constant surface area of the exposed surface is maintained.
Novel design frameworks for designing electrodialysis (ED) desalination systems for purifying brackish water are provided herein. The design frameworks of the present embodiments include one or more energy management strategies, as well as recirculation-based system architectures. The design frameworks can be independent of each other, or can be used together. In some embodiments, the energy management strategy can include determining a capacity of a battery in communication with an (ED) system and imposing a charge power limit onto the battery to limit the charging rate of the ED system. The energy management strategy can be used in combination with the recirculation-based system architectures to improve efficiency of purification performed by these ED systems. These architectures can include hybrid architectures that operate in continuous flow, but provide a recirculation stream to mix the feed to achieve a desired salinity of the product stream.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
17.
Streptococcus Canis Cas9 as a Genome Engineering Platform with Novel PAM Specificity
A Streptococcus canis Cas9 (ScCas9) ortholog and its engineered variants, possessing novel PAM specificity, is an addition to the family of CRISPR-Cas9 systems. ScCas9 endonuclease is used in complex with guide RNA, consisting of identical non-target-specific sequence to that of the guide RNA SpCas9, for specific recognition and activity on a DNA target immediately upstream of either an “NNGT” or “NNNGT” PAM sequence. A novel DNA-interacting loop domain within ScCas9, and other Cas9 orthologs, such as those from Streptococcus gordonii and Streptococcus angionosis facilitates a divergent PAM sequence from the “NGG” PAM of SpCas9.
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
18.
METHODS AND APPARATUS FOR AUTONOMOUS 3D SELF-ASSEMBLY, SPATIAL DOCKING AND RECONFIGURATION
A method for autonomously assembling a plurality of tiles is performed in a microgravity environment. Each tile includes a shell having a first geometrical shape and an arrangement of first magnets and a controller that are supported by the shell. The controller controls operation of the arrangement of first magnets to self-assemble the shell with another tile. The first magnets are controlled to mate with a complementary arrangement of second magnets on the other tile when the complementary arrangement of second magnets floats to within a range of magnetic attractive force of the arrangement of first magnets, with or without the aid of propulsion. The controllers in the tiles detect the status of the magnetic bonds to determine whether each pair of tiles is properly bonded or has a magnetic bond error. When an error is detected, the tiles are controlled to disassemble and reassemble to correct the error.
A transformable material and comprising a base material having a natural shape, with a second material disposed on the base material in a particular pattern so as to impose a transformed shape on the base material, the transformed shape being different than the natural shape. More particularly, the base material is a stretchable 2-dimensional material, and is subjected to pre-stressing before and during disposition of the second material, whereupon after release of the stress, the stretchable base material with the disposed second material thereon automatically transform into a predetermined 3-dimensional manufactured shape.
B29C 61/06 - Making preforms having internal stresses, e.g. plastic memory
B29C 55/16 - Shaping by stretching, e.g. drawing through a dieApparatus therefor of plates or sheets multiaxial biaxial simultaneously
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29K 105/00 - Condition, form or state of moulded material
20.
MEASURING REPRESENTATIONAL MOTIONS IN A MEDICAL CONTEXT
A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/16 - Devices for psychotechnicsTesting reaction times
G06Q 10/101 - Collaborative creation, e.g. joint development of products or services
G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
21.
SYSTEM AND METHOD FOR CO-DELIVERY OF AN AGENT AND AN ON-PATIENT MEDICAL RECORD SYSTEM WITH SPATIAL AND TEMPORAL ROBUSTNESS
A system delivers, to a living subject, a therapeutic dosage of an agent; delivers, to the living subject, an on-patient medical record (OPMR) comprising a two-dimensional array of dots, encoding information about the agent, reads data from the OPMR in the living subject; applies deep learning-based image processing to the read data to generate binary array data; applies error correction to the binary data to correct errors in the binary data, thereby producing error-corrected data; and translates the error-corrected data into an estimate of the information about the agent. The deep learning-based image processing includes applying deep learning-based image binarization to the read data to produce binarized image data, and applying deep learning-based image recognition to the binarized image data to generate the binary data.
The invention relates, in part, to methods and compounds for ultrastructure membrane expansion microscopy (umExM), which permits high-resolution visualization of membrane ultrastructure using light microscopy.
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
The invention, in some aspects includes methods and systems for expansion microscopy. Methods of the invention permit performance of iterative expansion protocols with the simplicity of one-shot protocols, achieving ~20x expansion of cell cultures and tissues in a single expansion step, and supporting post-expansion staining of biomolecules.
Disclosed herein are capped RNA transcripts comprising one or more modified nucleotides at position +3 or higher with reference to a 5' terminus of the RNA molecule, and methods of making the same. Also provided are compositions comprising one or more of the capped RNA transcripts provided herein, and methods of using said compositions for therapeutic applications.
Provided herein are lipid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a tissue or cell in a subject (e.g., a liver, lung, or spleen tissue/cell).
Provided herein are lipid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a tissue or cell in a subject (e.g., a liver, lung, or spleen tissue/cell).
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07C 233/47 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C07D 211/14 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 233/61 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
C07D 243/08 - Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
26.
SPLIT-LUCIFERASE REPORTER SYSTEMS, COLOR-CODED BEAD MULTIPLEX CRISPR SYSTEMS, AND METHODS OF USE THEREOF IN CRISPR-CAS BASED DIAGNOSTICS
Cas-cleavable reporter systems, CRISPR-Cas systems thereof, and methods of use thereof in CRISPR-Cas based diagnostics. Cas-cleavable reporter systems may generate a luminescent, fluorescent, or other detectable signal upon Cas-collateral cleavage of one or more reporter system components. CRISPR-Cas systems may comprise a Cas protein having collateral cleavage activity, guide molecules, and the Cas-cleavable reporter system. Cas-cleavable reporter systems may be a split luciferase reporter system, at least one element of which is bound to beads. For multiplexing, CRISPR-Cas systems may comprise a Cas-cleavable quenched reporter system, optionally a Cas-cleavable quenched fluorescent reporter system, a Cas protein having collateral cleavage activity, and target-specific guide molecules attached to color-coded beads. CRISPR-Cas systems may further comprise amplification reagents. Methods may apply said CRISPR-Cas systems to flow cell, well-plate, or other devices, and may measure detectable signals by microscopic, plate reader, or other methods.
Described herein are engineered paraneoplastic Ma protein (PNMA) capable of forming a capsid. In some embodiments, the engineered PNMA proteins comprise one or more modifications that enhance binding or loading of a cargo into the capsid, one or more modifications that modify cell-specificity of the capsid, one or more modifications that enhance intracellular delivery of the capsid, or a combination thereof. Also described herein are delivery systems comprising capsids comprising an engineered PNMA protein and a cargo.
A multi-armed bandit (MAB) problem is obtained and a per-round regret lower bound is determined, wherein a corresponding regret is measured against a benchmark. The multi-armed bandit problem is provided to an algorithm that has a per-round regret that is close to the determined per-round regret lower bound, wherein the algorithm dynamically adapts to changes and discards irrelevant past information by alternating between recently pulled arms and unpulled arms having potential, wherein the alternating comprises updating an estimate of an expected reward of each arm within each epoch and an estimate for an error bound that captures an amount of error contained in the estimate of the expected reward for each arm within each epoch based on the auto-regressive temporal structure with trend components, and restarting the algorithm.
Apparatus and methods for monitoring emissions from a borehole to determine the composition of earthen material removed from the borehole are described. Monitoring can be done in real time as the borehole is being deepened with a millimeter-wave drilling beam. The present technology can monitor in real-time the elemental composition of the earthen materials (e.g., rock, minerals, crystals, metals, etc.) in a borehole created by a directed-energy beam that melts and vaporizes the earthen material materials in its path. Using a continuous emissions monitor (CEM) in combination with directed-energy excavation of a borehole enables rapid surveying of the subsurface for precious and commercial metals.
G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
E21B 7/15 - Drilling by use of heat, e.g. flame drilling of electrically generated heat
E21B 49/00 - Testing the nature of borehole wallsFormation testingMethods or apparatus for obtaining samples of soil or well fluids, specially adapted to earth drilling or wells
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Optical and electronic processors for calculating second-order and higher-order polynomials are described. A photonic processor can include an optical matrix multiplying unit OMMU that can perform vector-matrix multiplication. A portion of the inputs to the OMMU can be fed forward to combine with outputs from the OMMU when calculating polynomials. The described apparatus can also be used for probabilistic computing and polynomial combinatorial optimization.
G06E 1/04 - Devices for processing exclusively digital data operating upon the order or content of the data handled for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation
This disclosure is directed to a targeted delivery vehicle that can deliver a cargo to a cell of interest. The targeted delivery vehicle has a fusogen and a targeting domain which are embedded in a lipid bilayer membrane that forms a vesicle, and a cargo within the vesicle. The disclosure is also directed to methods for targeted delivery of cargo using the targeted delivery vehicle described herein.
Described herein are systems and techniques for estimating a shape of a structure undergoing dynamic stress. In some embodiments, a method includes: for each of a plurality of nodes distributed along a length of the structure, obtaining, from an accelerometer located at the node, a tilt angle corresponding to an angle between a local axis of the structure and a direction of gravity; calculating, by a microcontroller, vertical displacements between adjacent pairs of the plurality of nodes using the respective tilt angles obtained for the adjacent pairs; and calculating, by the microcontroller, a depth of each of the plurality of nodes relative to a proximal end of the structure by adding the vertical displacements calculated for adjacent pairs of the plurality of nodes between the node and the proximal end of the structure.
G01B 5/18 - Measuring arrangements characterised by the use of mechanical techniques for measuring depth
G01B 5/213 - Measuring arrangements characterised by the use of mechanical techniques for measuring contours or curvatures for measuring radius of curvature
G01B 11/22 - Measuring arrangements characterised by the use of optical techniques for measuring depth
33.
CELL-TYPE SPECIFIC TARGETING CONTRACTILE INJECTION SYSTEM
The present disclosure relates generally to the field of delivery systems using contractile injection systems (CIS). Specifically disclosed are engineered extracellular CISs (eCISs) that can deliver non-natural protein payloads to non-natural target cells such as human cells. In addition, methods of using the engineered eCISs are also disclosed.
Tissue explants of the gastrointestinal tract are provided. Methods of making and using the tissue explants are also provided, along with substrates designed for the tissue explants described.
The present disclosure provides thionolactones (e.g., compounds of Formula II, and tautomers and salts thereof). The thionolactones may be useful as comonomers to copolymerize with other comonomers, e.g., methacrylates (e.g., MMA) to generate copolymers, e.g., random copolymers. The copolymers may be degradable (e.g., backbone degradable). The copolymers may be useful for waste management or biodegradability.
A61K 31/335 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/38 - Heterocyclic compounds having sulfur as a ring hetero atom
C25B 11/04 - ElectrodesManufacture thereof not otherwise provided for characterised by the material
H01M 12/06 - Hybrid cellsManufacture thereof composed of a half-cell of the fuel-cell type and of a half-cell of the primary-cell type with one metallic and one gaseous electrode
37.
Utilization Of Halides To Improve Diamond Properties
Described herein is a diamond and diamond products comprising:
a NV0 or SiV0 defect, wherein the NV0 or SiV0 defect comprises a nitrogen atom or silicon atom replacing a carbon atom in the diamond and a neutral vacancy replacing a carbon atom adjacent to the nitrogen atom or silicon atom in the diamond;
a NV− or SiV− defect, wherein the NV− or SiV− defect comprises a nitrogen atom or silicon atom replacing a carbon atom in the diamond and a negatively-charged vacancy replacing a carbon atom adjacent to the nitrogen atom or silicon atom in the diamond; and
a halide atom.
Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
The present disclosure provides compositions which enable the delivery of cargo, including therapeutic agents such as RNA, to organs or tissues in addition to the liver, lungs, and spleen, such as brain, heart, kidney, and muscle tissue. More specifically, the compositions comprise a plurality of lipid particles comprising an agent, cationic lipids and ionizable lipid.
Microstructures, their use, and methods for making microstructures are provided, where the methods involve applying an external stimulus to a plurality of packed, polymeric microspheres, wherein the polymeric microspheres have a porosity of between about 20% to 99%, and wherein at least a boundary layer of the polymeric microspheres are in contact with a surface; such that the polymeric microspheres collapse into smaller and denser microspheres that join with adjacent microspheres at contact points to form a micronetwork, wherein the contact points comprise microstructures extruded from the polymeric microspheres.
B01J 13/02 - Making microcapsules or microballoons
B29C 43/00 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
SYNTHESIS OF ESTER, CARBONATE, AND CARBAMATE-DERIVED NOVEL BIODEGRADABLE IONIZABLE LIPIDS FROM METHYL RICINOLEATE OR METHYL 12-HYDROXYSTEARATE AND ITS APPLICATIONS
Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
C07C 229/12 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
C07C 229/16 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
C07D 207/06 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
43.
SEPARATORS COMPRISING ELONGATED NANOSTRUCTURES AND ASSOCIATED DEVICES AND METHODS, INCLUDING DEVICES AND METHODS FOR ENERGY STORAGE AND/OR USE
The use of elongated nanostructures in separators and associated devices and methods, including devices and methods for energy storage and/or use, are generally described. According to certain embodiments, the elongated nanostructures can extend from a first solid substrate to a second solid substrate. In some embodiments, the nanostructures penetrate a surface of the first solid substrate (e.g., a first electrode) and/or a surface of the second solid substrate (e.g., a second electrode). The elongated nanostructures can, according to certain embodiments, provide structural reinforcement between two substrates (e.g., between two electrodes) while maintaining electronic insulation between the two substrates.
An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.
A clutch device includes two pluralities of flexible members interleaved with each other. An overlapping region is defined where the flexible members overlap each other. Non-overlapping regions are on opposing sides of the overlapping region. The non-overlapping regions are regions in which the flexible members do not overlap each other. In a locked arrangement, an outer portion of each non-overlapping region extends at a first angle relative to the overlapping region. The first angle causes the flexible members to engage and interlock with each other. The outer portions of can be moved to a second angle different than the first angle to unlock the clutch device and allow the flexible members to disengage with and be separated from each other. The clutch device thus does not require continuous energy input while also having a high locking force that can be rapidly applied or released.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
Systems, devices, and methods for the detection of analytes such as per- and polyfluoroalkyl substances (PFAS) in samples are generally described. Certain aspects of the present disclosure are related to systems for detecting analytes in samples. In some embodiments, a cartridge is used that comprises a plurality of microwells. The microwells can comprise, for example, a chamber and an optional cutout section. In some embodiments, the microwell has a volume of 0.001-1,000 pl (e.g., 0.1-100 pl), which can, for example, provide sufficient volume to detect the present of PFAS while also not being so large as to require a long amount of time before producing a result. In certain embodiments, the cartridge comprises a layer domain, which can hermetically seal the microwells. The layer domain can be, in some embodiments, configured to reseal after insertion of a needle.
G01N 9/24 - Investigating density or specific gravity of materialsAnalysing materials by determining density or specific gravity by observing the transmission of wave or particle radiation through the material
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 9/24 - Investigating density or specific gravity of materialsAnalysing materials by determining density or specific gravity by observing the transmission of wave or particle radiation through the material
Described is a partitioned cable joint comprising a plurality of physically distributed joint elements with the plurality of joint elements taken together defining a joint length. Joint elements may have a first mounting region having a shape selected to accept one petal of superconducting cable and a second mounting region having a shape selected to accept one petal of a second conductor.
Disclosed herein are methods and systems utilizing CRISPR effector systems for assays and diagnostics. Embodiments herein provide tile probes in systems and methods for detection of multiple targets across a given genome or group of genomes, including in circulating nucleic acid samples.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
One or more unit-test cases are generated from a monolingual code corpus and the generated unit-test cases are filtered to generate a corpus of unit-test cases which have acceptability scores exceeding one or more predefined thresholds. One or more of the code samples of the monolingual code corpus are translated from a source language to a target language using a pretrained Large Language Model and the generated unit-test cases are translated from the source language to the target language. The LLM-translated code samples are validated using the translated unit-test cases and a parallel-data training corpus comprising the LLM-translated code samples that pass the validation is created. The pretrained large language model (LLM) is fine-tuned using the parallel-data training corpus, a given code segment is translated using the fine-tuned large language model (LLM), the translated given code segment is tested and the tested given code segment is deployed.
Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomersynthesis while maintaining overall yield and purity of a synthesized oligomer.
Mammals rely on adaptive immunity to protect against infections and tumors, with the thymus playing a crucial role by producing T cells that target infected or cancerous cells. The thymus, however, undergoes functional decline with age, significantly impairing the immune system in the elderly. To investigate reversing this decline, compositions and methods for activation and differentiation of T cell progenitors in extrathymic tissues are disclosed that stimulate production of differentiated T cells. For example, LNP-mediated delivery of mRNAs encoding DLL-1, IL-7, and FLT3L to the liver is shown to create a temporary site for T cell maturation that enhances T cell-mediated immunity in aged mice without causing autoimmunity. This approach facilitates ectopic T cell development from hematopoietic precursors and activates dendritic cells, providing evidence that engineering adaptive immunity in vivo can effectively mitigate immune aging.
Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.
Systems, devices, or methods described herein may involve a human augmentation device configured to estimate the state of at least one implanted magnetic target. In some example embodiments, the device may comprise an array of sensors configured to measure one or more target field characteristics. In some example embodiments, the device may comprise a processing element configured to acquire measurements of the one or more target field characteristics and apply information-theoretic processing of the measurements to estimate in real-time the state and error covariance of at least one target state vector. In some example embodiments, the device may comprise a processing element configured to control an actuator of the human augmentation device.
An object includes an object body formed from a build material and a marker embedded in a part of the object body. The marker is formed from a fluorescent marker material configured to emit radiation with a first wavelength when exposed to radiation with a second wavelength. The build material in the part of the object body is translucent to radiation with the first wavelength and the second wavelength.
G06K 7/12 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using a selected wavelength, e.g. to sense red marks and ignore blue marks
Provided herein are antisense oligomer conjugates. In one embodiment, the antisense oligomer conjugates comprise a phosphorodiamidate morpholino oligomer (PMO) which is covalently linked to a cell-penetrating peptide (CPP). Also provided herein are methods of treating a muscle disease, such as Duchenne muscular dystrophy, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject one or more of the antisense oligomer conjugates described herein.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing science educational mentoring services and programs; providing educational demonstrations; providing training and mentorship in the fields of innovation, product design, product development, scientific research, entrepreneurship, problem solving, and business; developing curriculum for educators; organization of exhibitions for cultural or educational purposes; providing information relating to educational and entertainment activities and events for children; educational services, namely, providing a learning and innovation center featuring fully customized leadership, motivational, educational, and brainstorming training; providing information relating to education services; providing courses of instruction at the kindergarten level; providing courses of instruction at the primary level; providing courses of instruction at the high school level; providing courses of instruction at the undergraduate level; providing courses of instruction at the post-graduate level; educational services, namely, developing, arranging, and conducting educational conferences and programs in the fields of innovation, product design, product development, scientific research, entrepreneurship, problem solving, and business; educational services, namely, providing classes and workshops in the fields of innovation, product design, product development, scientific research, entrepreneurship, problem solving, and business; arranging and conducting educational competitions for students in the fields of science, innovation, product design, product development, and business
59.
SYSTEMS AND METHODS FOR SEPARATION OF CARBON DIOXIDE
Polyamines are water-soluble polyelectrolytes with the amino groups that can be used to attach the polymers onto functional surfaces of fibrous materials. In addition, polyamines can be readily modified by (super)nucleophilic groups such as (alkyl)aminopyridines that enhance the polymer's ability to promote hydrolysis of organophosphorous chemical warfare agents. Furthermore, attachment of hydantoin moieties augments the number of the imide, amide, or amine groups groups on the polyamine's chain, which provides oxidizing properties to the resulting modified polyamine after halogenation. In one aspect, disclosed herein are polyamines with side chains modified to contain both (4-aminopyridine, APy) and 5-(4-hydroxybenzylidene)hydantoin (HBH) functionalities with enhanced content of the active bromine. Viricidal activity of the APy- and HBH-modified polyallylamine against human coronavirus (type 229E) was tested both in solution and on nylon-cotton fabric. The polymers are effective at inactivating the coronavirus, at both low concentrations and short exposure times.
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
C08F 226/06 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
61.
CONFORMABLE ULTRASOUND SCANNING AND IMAGING METHODS AND APPARATUS AND RELATED TECHNIQUES
Described herein is a patch, comprising: a honeycomb structure comprised of two or more cells, wherein each of the two or more cells include a window and one or more first attachment means; and a tracker comprised of a sensor and one or more second attachment means configured to mate with the first attachment means to arrange the sensor in the window, wherein the tracker is moved to different ones of the cells to traverse a path along the patch. In some embodiments, the two or more cells have a regular or irregular shape. In embodiments, there are two or more first attachment means and two or more second attachment means that mate to form a first position and a second position, wherein the tracker is configured move between the first position and the second position.
A multistage water treatment system that requires minimum energy and can be powered by low-grade energy sources, such as sunlight, is disclosed. The system may include multiple stages, where each stage comprises a hydrophobic membrane, a confined saline layer, and a condenser. Using a saline layer as the evaporator, as confined by a hydrophobic membrane, strong thermohaline convection is initiated to mitigate salt accumulation and enhance heat transfer. The multistage water treatment system is salt-resistant during continuous desalination of nearly saturated saline. Such a system enables water treatment by low-grade heat with water production exceeding the single-stage limit and ultrahigh salinity. This system is useful for water treatment, including seawater desalination, wastewater reclamation, residential water softening, and salt production from brine/seawater.
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
TRUSTEES OF DARTMOUTH COLLEGE (USA)
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
Strey, Lilianne R.
Strey, Helmut
Granger, Richard M.
Edelman, Alan
Rackauckas, Christopher
Miller, Earl K.
Abstract
A system for generation and execution of brain circuit simulators includes at least one modular, hierarchical design comprising a plurality of micro-circuits. The system includes a neural control circuit simulator executing a simulation of the at least one design. The system includes a user interface comprising at least one interface element for manipulating output of the neural control circuit simulator. A method includes receiving, by a neural control circuit simulator, an identification of at least one modular, hierarchical design comprising a plurality of micro-circuits, the at least one modular, hierarchical design generated by a first user. The neural control circuit simulator executes a first simulation of the at least one design, using a first data set as simulation input. The neural control circuit simulator receives a second data set and executes a second simulation of the at least one modular, hierarchical design, using the second data set as simulation input.
FAN1FAN1 derived from the pre-mRNA in a target cell. The compositions and methods are particularly suited for treating, ameliorating, or delaying the onset of a trinucleotide repeat expansion disorder in a subject in need thereof.
Compositions and methods thereof for increasing endogenous FAN1 expression in a target cell are provided. Preferably, compositions include one or more splice switching antisense oligonucleotides targeting FAN1 exon 10-intron 10-exon 11 junction. The compositions are effective in increasing levels of functional FAN1 mRNA transcripts encoding FAN1 derived from the pre-mRNA in a target cell. The compositions and methods are particularly suited for treating, ameliorating, or delaying the onset of a trinucleotide repeat expansion disorder in a subject in need thereof.
Insulin therapy revolutionized the care of patients with diabetes, yet insulin-induced hypoglycemia remains a serious life-threatening complication of insulin therapy. Glucagon is a highly effective treatment for hypoglycemia; however, current dosage forms remain under- utilized due to poor patient compliance. High-density, readily soluble, and thermostable solid glucagon formulations applied with painless, application-specific microneedle-patches can treat hypoglycemia in type 1 diabetes patients who are awake or asleep. On-demand patches can prevent or treat mild hypoglycemia during the day, and enzyme-driven hypoglycemia-responsive patches can release glucagon autonomously during the night. These patches have excellent in vitro glucagon stability, loading, and release kinetics and can treat hypoglycemia in diabetic humans and animals. These delivery systems enable new modes of glucagon therapy, thereby expanding the clinical role of glucagon beyond the emergency setting.
Ingestible and/or implantable low power battery and signaling systems are generally provided. Advantageously, the systems and methods described herein may provide, in some embodiments, secure communication such that only authorized users and/or medical professionals can read sensor data and/or send valid commands to a system. Advantageously, the system and methods described herein may provide, in some embodiments, an energy-efficient security protocol to further improve the wireless communication (e.g., of an ingestible and/or implantable article). In some embodiments, the security protocol advantageously provides data encryption to protect sensor and command information and mutual authentication to prevent unauthorized access to both ingestible and external devices.
A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
70.
CYCLIC RUTHENIUM BENZYLIDENE INITIATORS FOR ENHANCED RING EXPANSION METATHESIS POLYMERIZATION
Cyclic ruthenium benzylidene initiators useful for the controlled synthesis of functionalized cyclic macromolecules via ring-expansion metathesis polymerization.
C08F 132/04 - Homopolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having no condensed rings having one carbon-to-carbon double bond
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
A method for making a lithium salt film includes heating a substrate, spraying a mixture with a spray nozzle onto the substrate to form a precursor film, and annealing the precursor film to form the lithium salt film. The lithium salt film has a thickness of about 400 nm to about 100 pm. The spray mixture includes a first precursor comprising a lithium ion, a second precursor comprising an anion, and a solvent.
C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
72.
READILY SOLUBLE AND THERMOSTABLE GLUCAGON FORMULATIONS AND DELIVERY FOR MINI-DOSING AND CLOSED -LOOP PROPHYLACTIC TREATMENT OF HYPOGLYCEMIA
Insulin therapy revolutionized the care of patients with diabetes, yet insulin-induced hypoglycemia remains a serious life-threatening complication of insulin therapy. Glucagon is a highly effective treatment for hypoglycemia; however, current dosage forms remain under-utilized due to poor patient compliance. High-density, readily soluble, and thermostable solid glucagon formulations applied with painless, application-specific microneedle-patches can treat hypoglycemia in type 1 diabetes patients who are awake or asleep. On-demand patches can prevent or treat mild hypoglycemia during the day, and enzyme-driven hypoglycemia-responsive patches can release glucagon autonomously during the night. These patches have excellent in vitro glucagon stability, loading, and release kinetics and can treat hypoglycemia in diabetic humans and animals. These delivery systems enable new modes of glucagon therapy, thereby expanding the clinical role of glucagon beyond the emergency setting.
The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof.
C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof
C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
G16B 50/30 - Data warehousingComputing architectures
Obtain, using at least one hardware processor, data characterizing a physical system governed by a physical conservation law. Apply, using the at least one hardware processor, contrastive learning to the data to automatically capture system invariants of the physical system. Employ, using the at least one hardware processor, a neural projection layer to guarantee that a corresponding dynamic machine learning model preserves the captured system invariants. Optionally, predict performance of the physical system using the corresponding dynamic machine learning model.
Disclosed are systems and methods for adjusting an infusion rate of a drug being delivered to a patient. The method includes extracting a fluid sample from the patient, isolating a drug filtrate by processing the fluid sample within a first time period, and analyzing the drug filtrate for a drug concentration using chromatography system, a mass spectrometry system, or both within a second time period. The method further includes comparing, using a control process, the drug concentration with a target concentration range, and adjusting the infusion rate of the drug to ensure the drug concentration is within the target concentration range.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
76.
FLUORINATED SULFONAMIDE-BASED ELECTROLYTES FOR NON-LITHIUM BATTERIES THEREOF
Disclosed are compositions, electrolytes, electrochemical cells, and batteries comprising a halogenated sodium salt; a halogenated sulfonate; and a co-solvent.
A non-insulated superconducting magnet and related methods and systems are provided herein. In some aspects, the non-insulated superconducting magnet comprises at least one heating element configured to induce a quench of the non-insulated superconducting magnet by asymmetrically heating the non-insulated superconducting magnet. In some aspects, the non-insulated superconducting magnet comprises at least one cable comprising at least one heating element configured to induce quench of the non-insulated superconducting magnet by heating the non-insulated superconducting magnet. In some aspects, the non-insulated superconducting magnet comprises a first plate having at least one groove arranged in a plurality of turns, and a conductor disposed in the at least one groove, wherein a resistivity of the conductor varies along a length of the conductor.
A mobile physical telemedicine system includes a processing system and at least one robotic manipulator communicatively coupled to the processing system and configured to support and manipulate a body part of a subject. In some embodiments, the system includes a motion capture system communicatively coupled to the processing system and configured to capture a motion of the subject. In some embodiments, the system includes an adjustable therapy bench. In some embodiments, the system includes a base supporting the at least one robotic manipulator, the motion capture system, and the adjustable therapy bench. In some embodiments, the at least one robotic manipulator is configured to be controlled remotely by a clinical provider. In some embodiments, the at least one robotic manipulator is configured to be operated in an autonomous mode.
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
79.
Chemical and Physical Sensing with a Reader and RFID Tags
A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor. A smartphone-based sensing strategy can use chemiresponsive nanomaterials integrated into the circuitry of commercial Near Field Communication tags to achieve non-line-of-sight, portable, and inexpensive detection and discrimination of gas phase chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-per-million concentrations.
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
G06K 19/077 - Constructional details, e.g. mounting of circuits in the carrier
G08C 17/02 - Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
80.
ULTRA-HIGH RESOLUTION MAPPING OF 3D GENOME STRUCTURE USING REGION CAPTURE MICRO-C
A method for identifying nucleic acid regions which interact with each other in genomic DNA, the method including the steps of: (1) crosslinking genomic DNA (including chromatin) in cells; (2) digesting the crosslinked genomic DNA to obtain fragments; (3) fragment end labelling; (4) ligating nucleic acid fragments; (5) obtaining a purified DNA fraction of ligation products including mainly di-nucleosomes; (6) preparing a sequencing library from the DNA fraction of ligation products mainly di-nucleosomes; and (7) performing tiling region capture of a region of interest.
A method for identifying nucleic acid regions which interact with each other in genomic DNA, the method including the steps of: (1) crosslinking genomic DNA (including chromatin) in cells; (2) digesting the crosslinked genomic DNA to obtain fragments; (3) fragment end labelling; (4) ligating nucleic acid fragments; (5) obtaining a purified DNA fraction of ligation products including mainly di-nucleosomes; (6) preparing a sequencing library from the DNA fraction of ligation products mainly di-nucleosomes; and (7) performing tiling region capture of a region of interest.
Selection of processing steps/reagents in the disclosed method provides a significantly improved method when compared to prior methods such as Hi-C, Micro-C, Micro-Capture-C (MCC), and Tiled-Micro-Capture-C (TMCC) in terms of reduction in cost, significantly improved efficiency, with capture of genomic interactions including enhancer-promoter interactions such as microcompartments.
A multi-phase electrolyte film includes a first phase comprising a metal oxide, wherein the metal oxide is amorphous, crystalline, or a glass; and a second phase comprising a lithium salt having a decomposition temperature in air of greater than 200° C. or a lithium halide. The first phase is dispersed in the second phase and has an average particle size of 5 to 200 nanometers. Methods for the manufacture of the electrolyte film are also disclosed.
Provided herein are systems, devices, and methods for carbon capture and storage. A system for carbon capture and storage may comprise a chamber containing an aqueous solution, as well as a cathode and anode immersed in the aqueous solution. The system may further comprise a power supply connected to the cathode and the anode. The power supply may be configured to apply a voltage across the cathode and the anode, resulting in the electrochemical production of minerals as a solid precipitate.
Systems and methods disclose a practical implementation of optimal modulation (OM) for the Complex Additive White Gaussian Noise (CAWGN) channel. At the sender, we map from uniform distributions of data to non-uniform distributions of points in constellations by using a technique inspired by Huffman codes. We replace Gray codes with a bit mapping suited to our constellations, where different points may map to string of bits of different lengths. At the receiver, we perform distribution-aware detection. The differing lengths of bits for modulation points can used as a simple checking mechanism that, when combined with guessing random additive noise decoding (GRAND), yields bit-error-rate (BER) advantages.
The Research Foundation for the State University of New York (USA)
Inventor
Khaykovich, Boris
Zheng, Guiqiu
Sprouster, David
Abstract
A system for determining atomic structure and dynamics of salt under certain temperatures as a function of temperature above and below salt melting, contains a quartz tube containing a first end and a second end, and a graphite rod that is located within the quartz tube. The graphite rod contains a hollow center that extends from a top portion of the rod to a location prior to a bottom of the rod, wherein the bottom portion of the rod is enclosed. A sample of salt is located within the hollow center of the graphite rod. A filling material having the characteristics of not reacting to the graphite rod and not changing state with heating of the salt to a melting point of the salt, and wherein the filling material is positioned beneath the graphite rod between the second end of the quartz tube and the bottom of the graphite rod.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 1/44 - Sample treatment involving radiation, e.g. heat
85.
CONTROLLABLE TRANSFORMATION NETWORKS FOR RADIO FREQUENCY POWER CONVERSION
In one aspect, a system for transforming a radio frequency (RF) signal between a source and a load can include: a first port and a second port connected to different ones of the source and the load; a first filter connected to the first port; a second filter connected to the second port, at least one of the first and second filters operable to provide variable reactance using dynamic frequency tuning (DFT); a two-port switching network connected between the first filter and the second filter, the switching network comprising a plurality of switches; and a controller coupled to the switching network and to the source, the controller configured to operate the plurality of switches according to a switching pattern and to dynamically adjust a frequency of the RF signal to provide controllable impedance matching between the first port and the second port.
H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters
H02M 5/293 - Conversion of AC power input into AC power output, e.g. for change of voltage, for change of frequency, for change of number of phases without intermediate conversion into DC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
H02M 7/5387 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
86.
Sequentially Stacked Multi-Stage Desalination System and Method
A sequentially stacked multi-stage desalination system includes a single pair of electrodes, including an anode and a cathode; at least one ion concentration polarization device; and at least one electrodialysis device coupled with the ion concentration polarization device and configured to receive liquid flow from the ion concentration polarization device. Each ion concentration device and electrodialysis device is positioned between the anode and the cathode.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis
A system for rigid motion correction for magnetic resonance imaging (MRI) of a subject includes an input for receiving motion corrupted k-space data for the subject acquired using an MRI system, a motion parameter estimation module coupled to the input and configured to estimate motion parameters based on the motion corrupted k-space data, a motion correction neural network coupled to the input and the motion parameter estimation module and configured to generate motion corrected k-space data based on the motion corrupted k-space data and the estimated motion parameters, and a reconstruction module coupled to the motion correction neural network and configured to generate a motion corrected image from the motion corrected k-space data.
Described herein is an expander comprising a resonator having a resonator chamber and an input port, wherein the input port is configured to be coupled to a fluid source having a first pressure and a first temperature. In some embodiments, the expander comprises a first acoustic driver disposed at the input port of the resonator, wherein in response to pressure applied thereto, the first acoustic driver oscillates between an open state and a closed state to generate an acoustic wave within the resonator chamber. In some embodiments, the first acoustic driver comprises one of: a reed valve, a jet edge valve, a rotary valve, a high-speed computer controlled valve, or a solenoid valve. In some embodiments, in response to pressure applied thereto, the first acoustic driver oscillates between the open state and the closed state at a frequency that substantially matches a resonant frequency of the resonator chamber.
F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
F25B 9/14 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point characterised by the cycle used, e.g. Stirling cycle
F28D 21/00 - Heat-exchange apparatus not covered by any of the groups
89.
REPLACING SYNTHETIC FERTILIZERS BY ENGINEERING CEREAL-ASSOCIATED NITROGEN-FIXING BACTERIA TO RELEASE UREA
Nitrogen is one of the primary nutrients essential to all forms of life. However, only a few plant species can live in a symbiotic relationship with nitrogen-fixing bacteria and nitrogen must first be converted to a form that plants can utilize. Accordingly, aspects of the present disclosure relate to providing nitrogen fixation to cereal plants using genetically engineered bacteria. In some embodiments, genetically engineered bacteria comprise engineered nucleic acids encoding one or more urea metabolism regulators and/or effect the activity of one or more urea metabolism regulators. In some embodiments, the genetically engineered bacterium release more extracellular urea compared to wildtype counterparts. In some embodiments, extracellular urea is ultimately broken down into ammonia and carbon dioxide which are subsequently used by a plant cell to produce amino acids and glucose, respectively.
Custom folded 3-dimensional plate lattices are modularly assembled to form structures with single and double curvature for use in structural engineering and robotics applications. The plate lattice structural corrugation uses a building block strategy and incorporates custom modified unit cells based on a Kirigami Expanded Miura pattern. This transformation involves expanding the top and bottom zig-zag crease lines into facets and orienting them in space. The structure of these lattices allows for the design of anisotropies in their flexural stiffness by alternating between the Maxwell criterion on bending-dominated and stretch dominated cells. These anisotropies can have value differences of up to 24 times with the same geometry, making them ideal for robotic morphing applications.
Additive manufacturing using bonding of voxels and related systems, devices, and articles are generally described. Certain embodiments are related to additive manufacturing with microscale resolution using solid-state kinetic bonding of microparticles or microfabricated thin-film voxels.
Some embodiments relate to a system for performing a multi-party computation among a plurality of parties. The system receives encrypted data sets generated by devices associated with the plurality of parties, wherein each of the encrypted data sets is generated by a respective one of the devices by encrypting data using a key shared among the devices. The system performs a computation on an aggregate of the encrypted data sets to obtain an encrypted result of the computation. The system transmits the encrypted result of the computation to at least two of the devices. The system receives partially decrypted shares of the encrypted result generated by the at least two devices, wherein each of the partially decrypted shares is generated by a respective one of the least two devices by partially decrypting the encrypted result using a private key of the respective device. The system generates a decrypted result of the computation using the partially decrypted shares of the encrypted result.
Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration/exfiltration) in a processing pipeline.
G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry
G01J 5/10 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors
G05D 1/689 - Pointing payloads towards fixed or moving targets
G05D 105/80 - Specific applications of the controlled vehicles for information gathering, e.g. for academic research
G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
An electrical joint includes a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions. Also described is a method of forming an electrical joint, comprising forming a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions.
A high capacity current lead (10) comprises components that are electrically coupled using indium joints. The current lead includes a heat exchanger having a portion at room temperature (100) and a portion (200) within a vacuum cryostat. The room-temperature portion is temperature controlled against both overheating and over-cooling. The cryogenic portion (200) of the heat exchanger is electrically coupled to a coolant boiling chamber (300) using indium joints. The boiling chamber (300) has a lid and a base that may be electrically coupled using indium joints, or they may be brazed. The boiling chamber (300) is surrounded by a vacuum lid that may be electrically coupled to the base using indium joints, or brazed. The base is electrically coupled to a superconductor module (400) having high-temperature superconductor (HTS) tapes for conveying current to a device, such as a superconducting electromagnet.
Articles, compositions, and methods describing particles comprising micelles are generally described. In some embodiments, the micelles are configured to absorb pollutants from water and subsequently release the pollutants to a non-aqueous environment.
Multifunctional microelectronics fiber probes can be chronically implanted in tissue of awake-behaving animals for understanding brain-viscera communication. These fiber probes can be made using thermal drawing to make hundreds of meters of flexible fiber that incorporates features such as light sources, electrodes, thermal sensors, and microfluidic channels in a multilayered configuration. The fiber mechanics can be tuned for two distinct device layouts: (1) higher-modulus, flexible brain fibers for implantation into deep-brain; and (2) soft, compliant gut fibers for implantation into the small intestine. Brain fibers can modulate the deep-brain mesolimbic reward pathway. Gut fibers can perform peripheral optogenetic stimulation of vagal afferents from the intestine to stimulate brain reward neurons. Brain and gut fibers can be connected to a control module, for example, with a coiled, stretchable interconnect that is more flexible and stretches more than even soft gut fibers, in dual-organ (gut-brain) implantation.
Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.
Provided herein are oligonucleotides, cell-penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
100.
SYSTEMS, METHODS, COMPOSITIONS, AND DESIGNS FOR SYNTHESIS AND USE OF EXTREME-WATER-UPTAKE, LEAKAGE-FREE HYGROSCOPIC HYDROGELS
Systems, methods, compositions, and designs for synthesis and use of hygroscopic hydrogels are provided. Hygroscopic hydrogels can be used as scalable and low-cost sorbents for atmospheric water harvesting, dehumidification, passive cooling, and/or thermal energy storage. Sorbent materials can be loaded with salt by soaking the gel in an aqueous solution to form hygroscopic composites. The swelling dynamics of hydrogels in aqueous lithium-chloride solutions, its implications on hydrogel salt loading, as well as the resulting vapor uptake of the synthesized hydrogel-salt composites can be performed. Equilibrating the swelling process of the hydrogels can result in hydrogels with high water uptake and leak-free sorbents that significantly outperform comparative hydrogels.
