Abrégé

A method of monitoring a particle size distribution (PSD) is provided. At least a partially coherent pupil-engineered beam may be produced. A plurality of particles having a particle size distribution (PSD) may be illuminated by the pupil-engineered beam to produce scattered light. The scattered light may be captured by a pixelated photoelectric detector, thereby creating a raw speckled image. An intensity correlation of the raw speckled image may be computed. The intensity correlation may be provided to an inverse module. The inverse module may be configured to determine the PSD based on the intensity correlation. The PSD may be obtained from the inverse module.

Classes IPC  ?

• G01N 15/0205 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques
• G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
• G01N 15/0227 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’imagerieRecherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’holographie

Abrégé

A method of synthesis of aluminum-doped Li6.25Al0.25La3Zr2O12 (Al-LLZO) can include preparing a precursor solution by dissolving lithium nitrate, aluminum nitrate, zirconium (IV) oxynitrate, and lanthanum nitrate in stoichiometric amounts according to the composition Li6.25Al0.25La3Zr2O12 in water, and decomposing droplets by passing through a co-flow burner. Also disclosed is a method of produce producing a thin-tape comprising Al-LLZO.

Classes IPC  ?

• H01M 10/0562 - Matériaux solides
• C23C 4/11 - Oxydes
• C23C 4/129 - Pulvérisation à la flamme

Abrégé

A system and method provide a hybrid communication scheme that achieves high communication rates with post-quantum computational security guarantees. Messages to be securely communicated are first mixed using an individually secure encoding, such as a linear network code, and some of the encoded messages are further encrypted. The encrypted and unencrypted messages are sent via different communications channels. Each unencrypted message becomes almost as secure as the encrypted messages because of the pre-mixing, since decoding any one of the messages requires all of the messages, including the encrypted messages. Thus, a very few encrypted messages may be used, allowing the rate of communication to approach one as the number of channels increases. This is particularly beneficial when a classical public-key cryptosystem can only be used in part of the data transmitted or stored, in the presence of noisy channels, in distributed data storage, and other applications.

Classes IPC  ?

• H04L 9/08 - Répartition de clés
• H04L 9/30 - Clé publique, c.-à-d. l'algorithme de chiffrement étant impossible à inverser par ordinateur et les clés de chiffrement des utilisateurs n'exigeant pas le secret
• H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système

Abrégé

A lithium ion conductor includes a compound of Formula 1: A lithium ion conductor includes a compound of Formula 1: Li7−a*α−(b−4)*β−xMaαLa3Zr2−βMbβO12−x−δXxNδ  Formula 1 A lithium ion conductor includes a compound of Formula 1: Li7−a*α−(b−4)*β−xMaαLa3Zr2−βMbβO12−x−δXxNδ  Formula 1 wherein in Formula 1, Ma is a cationic element having a valence of a, Mb is a cationic element having a valence of b, and X is an anion having a valence of −1, wherein, when Ma comprises H, 0≤α≤5, otherwise 0≤α≤0.75, and wherein 0≤β≤1.5, 0≤x≤1.5, (a*α+(b−4)β+x)>0, and 0<δ≤6.

Classes IPC  ?

• H01M 10/0562 - Matériaux solides
• C01B 21/082 - Composés contenant de l'azote et des non-métaux
• H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 4/40 - Alliages à base de métaux alcalins
• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium

Abrégé

Systems and methods for obtaining real-time, continuous measurements of a sample of a biological cell culture through tubing of a bioreactor by using a magnetic resonance relaxometer (MRR) device. The system pumps samples through tubing of a bioreactor (which comprises a bioreactor vessel holding the biological cell culture and the tubing through which a sample may be pumped). A portion of this tubing is routed through the MRR device and measurements are performed using magnetic resonance without the samples every leaving the bioreactor. Specifically, the return signals produced by the media (for example, water) in which the sample exists are analyzed to make inferences about the cells in the sample. The samples are then pumped back into the bioreactor vessel and returned to the culture such that none of the cells are destroyed while the measurements are obtained.

Classes IPC  ?

• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
• C12N 5/07 - Cellules animales ou tissus animaux

Abrégé

The present disclosure relates to methods of detecting and/or quantifying one or more target nucleic acid molecules in a sample, comprising: a) contacting the sample with a reaction mix comprising: i) reagents for amplifying the target nucleic acid molecules; ii) an Argonaute (Ago) enzyme, one or more guide single stranded uncleic acid molecules, and one or more reporter nucleic acid molecules; and iii) a pyrophosphatase (PPase) for regenerating Mg2+in the reaction mix; b) partitioning the mixture of the sample and the reaction mix into a plurality of compartments; c) amplifying the one or more target uncleic acid molecules in each compartment to obtain amplified target nucleic acid molecules; and d) detecting a signal in each compartment based on cleavage of the reporter nucleic acid molecules by the Ago enzyme in the presence of the amplified target nucleic acid molecules and guide single stranded nucleic acid molecules.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

A method of monitoring a particle size distribution (PSD) is provided. A plurality of particles having a particle size distribution (PSD) may be illuminated by an at least partially coherent beam to produce scattered light. The scattered light may be captured by a pixelated photoelectric detector, thereby creating an ensemble of raw speckled images. Based on the ensemble of the raw speckled images. an ensemble-averaged intensity correlation may be computed. The ensemble-averaged intensity correlation may be provided to an inverse module. The inverse module may be configured to determine the PSD based on the ensemble-averaged intensity correlation. The particle size distribution may be obtained from the inverse module.

Classes IPC  ?

• G01N 15/0205 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques
• G01N 15/0227 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’imagerieRecherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’holographie

Abrégé

Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use thereof for treating cancer are disclosed. Administration of the combination of the active agents can be effective to reduce cancer cell proliferation or viability in a subject with cancer to the same degree, or a greater degree than administering to the subject the same amount of either active agent alone. The active agents can be administered together or separately. Methods of selecting and treating subjects with cancers, particular prostate cancers including castration resistant prostate cancer, breast cancers, particularly androgen receptor positive breast cancers, and pancreatic cancers are also provided.

Classes IPC  ?

• A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
• A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
• A61K 31/4409 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 4, p. ex. isoniazide, iproniazide
• A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en position 17 alpha, p. ex. mestranol, noréthandrolone
• A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

Described herein are methods, devices, materials, and systems for extracting target materials from iron-rich feedstocks. The iron-rich feedstock may be red mud, a natural occurring mineral, and/or a waste stream. The target materials may include a main constituent of the feedstock, a rare earth element, a precious metal, and/or a platinum group element. The invention may use a combination of electrochemical reactions and physical separation methods.

Classes IPC  ?

• C22B 3/20 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation
• C22B 3/32 - Acides carboxyliques
• C22B 3/04 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation

Abrégé

A method of detecting one or more variants in the GEN1 genetic locus in a sample from a subject suffering from a cancer, or a healthy subject not yet diagnosed with cancer, wherein if the GEN1 mutation is detected, then a therapeutic agent inhibiting MUS81, EME1, or both is administered. The tumor cells or tissue are heterozygous for the variant(s) of GEN1 or have a loss of heterozygosity. The inhibitors used to target MUS81, EME1, or both are either small molecules, antibodies, PROTACs, bi-functional molecules, recombinant gene therapy vectors, RNAi agents, antisense RNA agents, or a gene editing system.

Classes IPC  ?

• A61K 31/15 - Oximes (C=N-O-)Hydrazines ( N-N)Hydrazones (N-N=)
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/12 - Gènes codant pour des protéines animales
• C12Q 1/686 - Réaction en chaine par polymérase [PCR]
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12N 15/86 - Vecteurs viraux
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 1/16 - LevuresLeurs milieux de culture
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger

Abrégé

Systems for assisting with a user's posture are disclosed. In some embodiments, the techniques described herein relate to a robotic system including a first base, one or more robotic limbs operatively connected to the first base and configured to be engaged with a body of a user of the robotic system, one or more sensors configured to sense pose information of the user proximate to the base, and one or more processors configured to determine a posture of the user based at least in part on the sensed pose information. The one or more processors may be configured to control the one or more robotic limbs to be engaged with the user's body based at least in part on the determined posture of the user.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
• B25J 13/08 - Commandes pour manipulateurs au moyens de dispositifs sensibles, p. ex. à la vue ou au toucher

Produits et services

Water bottles sold empty; Mugs; Cups; Coffee cups; Thermal insulated containers for food or beverage; Drinkware; Beverageware

Produits et services

Software as a service (SAAS) services for virtual assistants and artificial intelligence assistants in the field of entrepreneurship; software as a service (SAAS) services featuring software using artificial intelligence in the field of business; providing temporary use of online non-downloadable software using artificial intelligence in the field of entrepreneurship; providing temporary use of online non-downloadable software using artificial intelligence (AI) for AI assistant and chatbot services, language and speech processing, text generation, information, and database searching; providing temporary use of online non-downloadable software using artificial intelligence for collection, processing, organization, storage, analysis, modification, management, transmission, and sharing of data; providing temporary use of online non-downloadable software using artificial intelligence for providing interactive communications and assistance to users; providing temporary use of online non-downloadable software using artificial intelligence for creating and managing information; providing temporary use of online non-downloadable software using artificial intelligence for increasing usage efficiency of electronic devices by building the AI assistant's contextual understanding of the user over time through retrieval-augmented generation, and dynamic context development; providing temporary use of online non-downloadable software using artificial intelligence for a collaborative AI assistant for enhancing productivity and assisting users based on set directives and specifications; design and development of computer software; providing temporary use of online non-downloadable software in the field of business; providing temporary use of online non-downloadable software in the field of artificial intelligence; providing an internet website portal in the field of artificial intelligence; providing an internet website portal in the field of business

Produits et services

Clothing, namely, t-shirts, tops; t-shirts for children; t-shirts for adults; headwear; headwear, namely, hats and caps; shorts; bottoms as clothing

Abrégé

Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of <5% as calculated in accordance with ASTM standard D1003-13 and (ii) a U-factor of <0.5 BTU/sf/hr/° F., and a transparent polymer envelope sealed at an internal pressure of ≤1 atmosphere, wherein the monolithic silica aerogel slab is encapsulated in the transparent polymer envelope. The monolithic aerogel slab can have a transmittance>94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet.

Classes IPC  ?

• G10K 11/168 - Sélection de matériaux de plusieurs couches de matériaux différents, p. ex. sandwiches
• B32B 7/027 - Propriétés thermiques
• B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
• B32B 9/04 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes comprenant une telle substance comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique
• E06B 9/24 - Écrans ou autres dispositifs protecteurs contre la lumière, notamment contre la lumière solaireÉcrans similaires pour protection de l'intimité ou pour des raisons esthétiques

Abrégé

Some aspects relate to a toroidal field (TF) coil for a tokamak. The TF coil includes a first inner leg having teeth on a side of the first inner leg. The corresponds to an interface between the TF coil and a second TF coil. The teeth extend along a direction having a component in a radial direction of the tokamak. The teeth are configured to mechanically engage with second teeth of a second inner leg of the second TF coil.

Classes IPC  ?

• G21B 1/05 - Réacteurs de fusion thermonucléaire avec confinement magnétique ou électrique du plasma
• G21B 1/11 - Réacteurs de fusion thermonucléaire Détails
• H01F 6/06 - Bobines, p. ex. dispositions pour l'enroulement, l'isolation, les enveloppes ou les bornes des bobines

Abrégé

A lateral flow device, system and method can be used to detect an analyte by monitoring a change in an electronic property.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

Bulk nanocomposite materials comprising a solid support material and a plurality of elongated nanostructures distributed within the solid support material, and related systems and methods, are generally described. The elongated nanostructures occupy a volume fraction of at least 5 vol. %; less than or equal to 20 vol. % of the domain is occupied by voids having a volume of at least 10<7>micrometer<3>; the domain comprises a first dimension having a length of at least 1 centimeter; and the domain comprises a second dimension that is perpendicular to the first dimension, the second dimension having a length of at least 1 centimeter.

Classes IPC  ?

• B32B 27/20 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers utilisant des charges, des pigments, des agents thixotropiques
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites

Abrégé

A gene-targeting chimera including an adeno-associated virus (AAV) and a nanoparticle is disclosed. The nanoparticle may include a silica shell coating. The AAV and nanoparticle may be covalently attached using a linking chemistry. The nanoparticle may include a magnetic nanoparticle (MNP), a magnetic nanodisc (MND), or a quantum dot (QD). The gene-targeting chimeras may retain the tropism of original AAV serotype used. Additionally, The gene-targeting chimeras may also be able to be controlled using a magnetic field. The gene-targeting chimeras may enable nanoparticle delivery to specific cells and organs.

Classes IPC  ?

• C12N 15/86 - Vecteurs viraux
• C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation

Abrégé

Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

Classes IPC  ?

• C12N 9/22 - Ribonucléases
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome

Abrégé

The invention relates to compositions and methods for RNA editing. In particular, ribozymes can be utilized to enhance RNA trans-splicing.

Classes IPC  ?

• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
• A61K 38/46 - Hydrolases (3)
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12N 15/86 - Vecteurs viraux
• C12N 9/22 - Ribonucléases
• C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)

Abrégé

An apparatus for imaging a cavity. The apparatus comprises an enclosure, comprising a distal end, a proximal end, and a transparent portion therebetween. The proximal end comprises at least one electrical connection, and the transparent portion is transparent to an illumination signal; and a flexible tether, operably connected to the electrical connection of the proximal end of the enclosure. The enclosure further comprises an image acquisition device, an illumination source, and an annular reflector, wherein the illumination source is configured to generate the illumination signal comprising illumination beams, the annular reflector being configured to direct at least some of the illumination beams through the transparent portion of the enclosure at the cavity, thereby generating a reflected signal comprising reflected beams, the annular reflector being further configured to direct at least some of the reflected beams at the image acquisition device, the image acquisition device being configured to capture one or more images based on the reflected signal.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
• A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement

Abrégé

According to one aspect of the disclosure, a system for performing quantum computations includes: a first environment for being maintained at an ambient temperature, having a classical computing processor; and a second environment for being maintained at a cryogenic temperature, having a plurality of qubits and a multiplexing circuit coupled to the plurality of qubits, each of the plurality of qubits having a gap transition frequency; wherein the classical computing processor is configured to change the states of each of the plurality of qubits by controlling the multiplexing circuit to couple particular ones of the plurality of qubits to a pulsed baseband waveform.

Classes IPC  ?

• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit

Abrégé

Disclosed herein is a hybrid electronic-ionic circuit comprising a first electrochemical ionic synapse (EIS), wherein in response to a non-zero electrical stimulus applied to the first EIS, the first EIS operates in a volatile operation mode to generate a delayed-onset self-resetting signal; and a second EIS, wherein in response to a non-zero electrical stimulus applied to the second EIS, the second EIS operates in a non-volatile operation mode and a conductance of the second EIS controls a strength of an output of the second EIS. In some embodiments, the non-zero electrical stimulus for the first EIS comprises one or more of a context signal or a variability signal. In some embodiments, the non-zero electrical stimulus for the second EIS comprises one or more of the delayed-onset self-resetting signal, a reward signal, or a context signal.

Classes IPC  ?

• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c.-à-d. ISFETS ou CHEMFETS

Abrégé

A control system and method locates a partially or fully occluded target object in an area of interest. The location of the occluded object may be determined using visual information from a vision sensor and RF-based location information. Determining the location of the target object in this manner may effectively allow the control system to “see through” obstructions that are occluding the object. Model-based and/or deep-learning techniques may then be employed to move a robot into range relative to the target object to perform a predetermined (e.g., grasping) operation. This operation may be performed while the object is still in the occluded state or after a decluttering operation has been performed to remove one or more obstructions that are occluding light-of-sight vision to the object.

Classes IPC  ?

• B25J 9/16 - Commandes à programme
• G05B 19/4155 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par le déroulement du programme, c.-à-d. le déroulement d'un programme de pièce ou le déroulement d'une fonction machine, p. ex. choix d'un programme
• G06K 7/10 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation électromagnétique, p. ex. lecture optiqueMéthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire
• G06K 19/07 - Supports d'enregistrement avec des marques conductrices, des circuits imprimés ou des éléments de circuit à semi-conducteurs, p. ex. cartes d'identité ou cartes de crédit avec des puces à circuit intégré

Abrégé

The present disclosure, in various embodiments, discloses hydrothermal methods, hydrothermally modified materials and dried hydrothermally modified materials. Certain dried hydrothermally modified materials can readily releases ionic species such as alkali metal ions (K+, Na+), silicate salts, and alkaline earth metal ions (Mg2+, Ca2+). Some dried hydrothermally modified materials can readily release aluminum ions and/or silicon, such as in the form of soluble silicates. Such processes and materials are useful, for example in economically preparing potassium releasing fertilizers.

Classes IPC  ?

• C05D 1/04 - Engrais potassiques à partir de minerais ou de roches volcaniques
• C05D 3/00 - Engrais calciques
• C05D 5/00 - Engrais magnésiens
• C05D 9/02 - Autres engrais inorganiques contenant des éléments à l'état de traces

Abrégé

A detector for gamma irradiation comprises an oxygen ion conducting polycrystalline solid, has positively charged grain boundaries or negatively charged grain boundaries and is coupled to electrodes that measure changes in the polycrystalline solid's ionic conductance. The polycrystalline solid may include lightly doped Gd-doped CeO2, a polycrystalline ion conducting ceramic. The steady state passivation of space charge barriers at grain boundaries that may act as virtual electrodes, capturing radiation-induced electrons, in turn lowering space charge barrier heights, and thereby exclusively modulating the ionic carrier flow within the ceramic electrolytes. Such behavior may allow for an electrical response under low fields, i.e., <2 V/cm. The polycrystalline solids disclosed herein may be used in inexpensive, sensitive, low-power and miniaturizable solid-state devices, uniquely suited for operating in harsh (high temperature, high humidity, pressure, and/or corrosive) environments. The detectors disclosed herein may be suitable for simultaneous spectroscopy and dosimetry measurements.

Classes IPC  ?

• G01T 1/185 - Mesure de l'intensité de radiation avec des aménagements de chambre d'ionisation

Abrégé

A multi-axis actuated tailcone for an autonomous underwater vehicle (AUV) is provided. The AUV includes a removeable, interchangeable drive module, active and passive roll compensation, and removeable and interchangeable shrouds and fins for optimizing hydrodynamic performance. The tailcone includes a hull having an exterior surface and defining a cavity. A motor may include a shaft disposed at least partially within the hull. A drive module may be disposed in the cavity. The drive module includes one or more drivers. A plurality of fins are disposed about an exterior surface of the hull. Each fin is coupled to one of the one or more drivers. A propeller assembly is coupled to the shaft and includes a shroud.

Abrégé

The present disclosure provides engineered OMEGA guide molecules, trans-oligonucleotide activated OMEGA guide systems, and compositions and systems comprising engineered IscB polypeptides. Methods of modifying target polynucleotides using the compositions and systems described herein are also provided.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 9/22 - Ribonucléases
• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries

Abrégé

An integrated pixel cell for a display device and/or optical communication device, an LED array, and method of fabricating an integrated pixel cell for a display device and/or optical communication device. The integrated pixel cell for a display device and/or optical communication device comprises a light emitting element; a photo detecting element; CMOS circuitry for the light emitting element and the photo detecting element, wherein the CMOS circuitry, the light emitting element and the photo detecting element are provided on a same substrate of the integrated pixel cell; wherein the photo detecting element is configured to detect a part of radiated light from the light emitting element; and wherein output voltages or currents of the light emitting element and the light detecting element are detectable by a calibration circuit to calibrate the light emitting element's current or light intensity.

Classes IPC  ?

• H10F 55/155 - Dispositifs à semi-conducteurs sensibles au rayonnement couverts par les groupes , ou structurellement associés à des sources lumineuses électriques et électriquement ou optiquement couplés avec lesdites sources dans lesquels les dispositifs à semi-conducteurs sensibles au rayonnement commandent la source lumineuse électrique, p. ex. convertisseurs d'images, amplificateurs d'images ou dispositifs de stockage d'image dans lesquels les dispositifs sensibles au rayonnement et la source lumineuse électrique sont tous des dispositifs à semi-conducteurs formés dans ou sur un même substrat
• H10F 55/255 - Dispositifs à semi-conducteurs sensibles au rayonnement couverts par les groupes , ou structurellement associés à des sources lumineuses électriques et électriquement ou optiquement couplés avec lesdites sources dans lesquels la source lumineuse électrique commande les dispositifs à semi-conducteurs sensibles au rayonnement, p. ex. optocoupleurs dans lesquels les dispositifs sensibles au rayonnement et la source lumineuse électrique sont tous des dispositifs à semi-conducteurs formés dans ou sur un même substrat
• H10F 39/10 - Dispositifs intégrés
• H10F 39/18 - Capteurs d’images à semi-conducteurs d’oxyde de métal complémentaire [CMOS]Capteurs d’images à matrice de photodiodes

Abrégé

The present disclosure provides products and methods for facilitating brain lipid transport in a subject. In some aspects the products are useful for slowing the progression of or preventing the development of Alzheimer's Disease or for treating Alzheimer's disease. The products include reconstituted lipoprotein particles (rLPs). Libraries and screening of libraries to identify additional rLPs are also disclosed.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61K 9/1275 - Lipoprotéines ou groupes exempts de protéines, p. ex. chylomicronsLipoprotéines artificielles de haute densité [HDL], lipoprotéines de basse densité [LDL] ou lipoprotéines de très basse densité [LTBD]Leurs précurseurs

Produits et services

Entertainment in the nature of live performances by a costumed character or mascot; entertainment services, namely, live appearances by a costumed character or mascot; entertainment services, namely, public appearances by a costumed character or mascot, live or via broadcast over television, cable, satellite, and/or Internet; entertainment services, namely, arranging and conducting costumed character or mascot performances for others; entertainment services, namely, arranging and conducting costumed character or mascot appearances for others; rental of costumes; providing a website featuring non-downloadable videos in the field of entertainment

Produits et services

Entertainment in the nature of live performances by a costumed character or mascot; entertainment services, namely, live appearances by a costumed character or mascot; entertainment services, namely, public appearances by a costumed character or mascot, live or via broadcast over television, cable, satellite, and/or Internet; entertainment services, namely, arranging and conducting costumed character or mascot performances for others; entertainment services, namely, arranging and conducting costumed character or mascot appearances for others; rental of costumes; providing a website featuring non-downloadable videos in the field of entertainment

Abrégé

A procedure for using a scanning transmission electron microscope to determine atomic position is disclosed. A diagnostic scan pattern is executed and areas of high intensity in the resulting detector output are identified. These areas may represent the position of atoms in the sample. This output is then compared to the known or measured lattice structure of the sample, and the coordinates of the identified atoms are adjusted based on the comparison. This procedure avoids exposing a target region of interest, compensates for drift, and allows for precision to be improved compared to the case where the procedure is not used, reaching values that may be better than 10 picometers.

Classes IPC  ?

• G01N 23/225 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en mesurant l'émission secondaire de matériaux en utilisant des microsondes électroniques ou ioniques
• H01J 37/06 - Sources d'électronsCanons à électrons
• H01J 37/244 - DétecteursComposants ou circuits associés

Abrégé

The invention relates to moiré synaptic transistors and crossbar array comprising M columns and N rows of moiré synaptic transistors. The moiré synaptic transistor comprises a top gate, a bottom gate, and an asymmetric moiré heterostructure disposed between the top gate and the bottom gate; and a source and a drain spatial-apart formed on the asymmetric moiré heterostructure to define a conductance channel in the asymmetric moiré heterostructure therebetween, and wherein the top gate and the bottom gate are capacitively coupled with the conductance channel.

Classes IPC  ?

• H10D 30/67 - Transistors à couche mince [TFT]
• G06N 3/063 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques

Abrégé

This disclosure relates to lipidated synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E, methods of making such peptides, peptidomimetics, and complexes, and methods of using such peptides, peptidomimetics and complexes for blocking, inhibiting, or preventing the interaction of HLA-E with CD94/NKG2A or activation of CD94/NKG2A by HLA-E. The lipidated synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E can further comprise warheads to introduce covalent linkages between the synthetic peptides and peptidomimetics with HLA-E.

Classes IPC  ?

• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides

Abrégé

Some aspects are related to articles for delivering therapeutic agents to a location internal to a subject. In some embodiments, the articles may include a reservoir configured to contain a therapeutic agent, a magnetic component, and a tether linking the reservoir and the magnetic component. In some embodiments, a plurality of the articles may be ingested by a subject, and the magnetic component of the articles may self- assemble into a drug delivery system at a location internal of the subject. The reservoirs of the articles may contain a large amount of a therapeutic agent (e.g., up to 50 grams of therapeutic agent) in the system, in some embodiments, and the system may be configured to release the therapeutic agent over a long time (e.g., up at 365 days). Still other aspects are related to methods of administering and/or using the articles and systems, kits containing the same, or the like.

Classes IPC  ?

• A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p. ex. de remèdes, dans les cavités du corps

Abrégé

This disclosure relates to reversible affinity selection methods useful for the isolation and enrichment of covalent peptide inhibitors directly from large synthetic peptide libraries. Also disclosed herein are synthetic peptides for targeting HPV16 E6 and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 protein.

Abrégé

Provided herein are antisense oligomer conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject one or more of the antisense oligomer conjugates described herein.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif

Abrégé

Systems and methods for confining an optical signal in a non-linear optical quantum computing system are disclosed. An optical signal and a trap field are provided in the non-linear optical quantum computing system. The trap field propagates with and confines the optical signal in time and/or space. The non-linear optical quantum computing system may be structured as a ring, a single-pass waveguide or a segmented single-pass waveguide. In some cases, multiple optical signals may be input into the system and evaluated in a multiplexed fashion.

Classes IPC  ?

• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
• G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique

Abrégé

Provided are engineered viral vectors, compositions comprising viral vectors, and methods of producing and using engineered viral vectors. The engineered viral vectors provided herein include capsid proteins derived from densovirus (DNV). Such DNV capsid proteins can assemble in mammalian cells and encapsulate adeno-associated virus (AAV) and/or DNV genomic DNA. The engineered viral vectors may be used as delivery vectors in target gene therapies.

Classes IPC  ?

• C12N 15/86 - Vecteurs viraux

Abrégé

The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides Cas proteins and their use in modifying target sequences.

Classes IPC  ?

• C12N 9/22 - Ribonucléases
• C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome

Abrégé

Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and transposable elements. CRISPR-associated transposons (CASTs) are bacterial RNA-guided Tn7-like transposons that can insert large DNA cargoes at targeted loci in bacteria. To adapt CAST for use on the human genome, Applicants screened 30 CAST I-B systems for activity on extrachromosomal DNA in human cells. Of the six active orthologs identified, Applicants engineered a I-B2 system from Tolypothrix sp. PCC7910 (TolCAST) to achieve RNA-guided DNA insertion in the genome of living human cells.

Classes IPC  ?

• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 9/22 - Ribonucléases
• C12N 9/64 - Protéinases provenant de tissu animal, p. ex. rennine
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées

Abrégé

Provided herein, in various embodiments, are methods and compositions comprising a Signal Regulatory Protein Alpha (SIRPα) therapeutic. In certain embodiments, the disclosure provides for methods and compositions for modulating SIRPα expression. In certain embodiments, the methods and compositions are useful in the treatment of a SIRPα-mediated disease or condition.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Agents anticancéreux

Abrégé

According to embodiments of the present disclosure, a system includes: a microkernel having a low-level application programming interface (API) and providing memory protection domains to user-level processes; and an abstraction layer running on top of the microkernel and comprising a plurality of service extensions to the microkernel and configured to provide a high-level operating system (OS) API for use by one or more application processes running in user space, wherein different ones of the service extensions are configured to run within different ones of the memory protection domains provided by the microkernel.

Classes IPC  ?

• G06F 9/445 - Chargement ou démarrage de programme
• G06F 9/30 - Dispositions pour exécuter des instructions machines, p. ex. décodage d'instructions
• G06F 9/54 - Communication interprogramme

Abrégé

A method and apparatus used in preparing a recrystallized metal alloy involve a cooling medium and a heating element to create a cold zone and a hot zone. An additively manufactured metal alloy preform is drawn in a draw direction from the cold zone towards the hot zone to form the recrystallized metal alloy. The cold zone and the hot zone create a surface temperature gradient on at least a portion of the preform of at least about 104 K m−1. The step of drawing causes an average grain size of at least a portion of the preform to increase in a direction parallel to the draw direction.

Classes IPC  ?

• B22F 10/64 - Traitement de pièces ou d'articles après leur formation par des moyens thermiques
• B22F 10/28 - Fusion sur lit de poudre, p. ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]
• B22F 10/66 - Traitement de pièces ou d'articles après leur formation par des moyens mécaniques
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 40/20 - Posttraitement, p. ex. durcissement, revêtement ou polissage
• C22F 1/10 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid du nickel ou du cobalt ou de leurs alliages

Abrégé

The disclosure provides compositions and methods for identifying subjects having hepatocyte stress associated with a risk for developing hepatocellular carcinoma (HCC), and therapeutic methods for reducing a subject's risk of HCC, for example, by inhibiting RELB, SOX4, or HMGCS2.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

Hydrogel-based heterogenous catalysts, e.g., for oxidation of organic molecules, and related articles, systems, and methods, are generally described herein.

Classes IPC  ?

• B01J 35/00 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général
• B01J 35/20 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général caractérisés par leur état non solide
• C07C 2/84 - Préparation d'hydrocarbures à partir d'hydrocarbures contenant un plus petit nombre d'atomes de carbone par condensation d'hydrocarbures avec élimination partielle d'hydrogène par couplage oxydant catalytique

Abrégé

Mycobacterium tuberculosisMycobacterium tuberculosis-derived sequences for use as immunogens and vaccine compositions.

Classes IPC  ?

• A61K 39/04 - Mycobacterium, p. ex. Mycobacterium tuberculosis
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose
• C12N 15/861 - Vecteurs adénoviraux

Abrégé

Disclosed herein are silicates and/or salts and methods of production and uses thereof. For example, methods of producing an amorphous silicate and/or a salt from materials comprising silicates are disclosed. As another example, use of silicates and/or salts in the formation of cementitious materials is also disclosed.

Classes IPC  ?

• C04B 22/12 - Acides ou leurs sels comportant des halogènes dans la partie anionique, p. ex. chlorure de calcium

Abrégé

Provided herein are oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease in a subject in need thereof, comprising administrating to the subject oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates described herein.

Classes IPC  ?

• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

Aspects of the present disclosure relate, at least in part, to nucleic acids for expression of engineered genes in chloroplasts. In some embodiments, an engineered gene comprises a heterologous regulatory sequence (e.g., a promoter, a translation regulatory sequence, and/or RNA-binding proteins binding sequences). In some embodiments, nucleic acids described herein are useful for expressing peptides and/or proteins at levels that are controllable and not normally achieved when said genes are in their normal cellular environment. In some embodiments, nucleic acids described herein are useful in, for example, improving plant performance, providing resistance to plant pathogens, increasing plant growth, and production of agents which are therapeutic to a mammalian subject. In some embodiments, nucleic acids and methods described herein may be used for production of genetically engineered plants and/or seeds (e.g., of an edible crop or crops harvested for plant-based materials used in the manufacture of clothing, construction materials, etc.).

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/67 - Méthodes générales pour favoriser l'expression
• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 5/04 - Cellules ou tissus végétaux

Abrégé

Disclosed herein are anti-PAPP-A synthetic peptides showing potent inhibitory activity with pronounced selectivity towards PAPP-A and over other members of metzincin family, methods of making such synthetic peptides, and methods of using such synthetic peptides for active site-directed inhibition of PAPP-A.

Classes IPC  ?

• C07K 14/65 - Facteurs de croissance analogues à l'insuline, c.-à-d. somatomédines, p. ex. IGF-1, IGF-2
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains

Abrégé

A novel active and passive wafer-scale fabric is disclosed that allows for the integration of very-large-scale integrated circuits (ICs) with hundreds of closely-spaced bare-die chips such as memory, GPUs, FPGAs and AI accelerators into a single wafer. The wafer-scale logic fabric allows the tiling of known good chips to make systems that perform as a single-chip monolithic device, despite comprising several smaller heterogeneous chips. This approach enables higher bandwidth and lower connectivity loss than conventional circuit board packaging, which is especially critical for AI computing and signal/image processing applications. Further, it also allows for multiple levels of high-density connections, since this architecture allows wiring between chips to be as small as the wiring within a chip. This wafer-scale platform combined with heterogeneous IP block/chiplets and μ-bump integration produces a chip-like wiring for the wafer-scale heterogeneous multi-chip system where part of chip can be removed or reconfigured.

Classes IPC  ?

• H01L 27/118 - Circuits intégrés à tranche maîtresse

Abrégé

A reticle stage for a photolithography scanner is disclosed having a direct-drive ironless linear motor to actuate a short-stroke stage during a turnaround operation. The reticle stage may include a long stroke stage, an array of permanent magnets coupled to a beam, and at least one conductive coil mounted to the short-stroke stage without a ferromagnetic core. The beam may pass through the short-stroke stage and be coupled to one of the long-stroke stage or a balance mass, both of which may be disposed about the perimeter of the short-stroke stage. An electrical current applied to the coil may interact with the magnetic field from the permanent magnets to provide a force on the short-stroke stage.

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet

Abrégé

A reticle stage for a photolithography scanner having a pneumatic actuation system is disclosed. The pneumatic actuation system may provide a restoring force to a long-stroke stage during scan and turnaround operations. The reticle stage may have or define dual-chamber pneumatic pistons as energy storage devices to create turnaround forces for stage acceleration. As the long-stroke stage is driven by a linear motor a pressure differential is formed between the two pistons providing a net force opposing the direction of the long-stroke stage movement.

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet

Abrégé

Prompt embedding samples are drawn from a prior distribution and are passed into a pretrained model to receive a corresponding token label prediction for a batch of text data. Prompt embedding samples are accepted from a distribution of a first iteration; the accepted samples satisfy a condition of a distance function between a ground truth label and the corresponding token label prediction being less than a first tolerance. Embeddings are resampled from the accepted prompt embedding samples with probability proportional to weights and the resampled embeddings are perturbed via a perturbation kernel to obtain a new sample. The perturbed resampled embeddings are propagated through the pretrained model, and those that satisfy a condition are projected, where the second tolerance is decayed by one step per iteration. The projected resampled embeddings are concatenated with an embedding of a given input and inferencing is performed.

Classes IPC  ?

• G06F 40/284 - Analyse lexicale, p. ex. segmentation en unités ou cooccurrence

Abrégé

Disclosed are injectable needles. Also disclosed are methods of delivering a therapy to a subject in need thereof using the injectable needles.

Classes IPC  ?

• A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau

Abrégé

Devices and/or methods for generating and transferring triplet excitons to a silicon semiconductor are generally described. In certain embodiments, a device having a singlet fission layer (102, 202, 302, 402, 602), an organic semiconductor layer (104, 204, 304, 404, 604), a passivation layer (106, 206, 306, 406, 606), and a silicon semiconductor (108, 308, 408) are included. The singlet fission layer is capable of generating triplet excitons, which can be transferred to the silicon semiconductor. In one set of embodiments, an organic semiconductor layer assists with the transfer of triplet excitons. In another set of embodiments, the device comprises a radial junction, which can minimize the diffusion length of the photogenerated carriers and thus minimize recombination processes.

Classes IPC  ?

• H10K 30/10 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire comprenant des hétérojonctions entre des semi-conducteurs organiques et des semi-conducteurs inorganiques
• H10K 30/57 - Dispositifs photovoltaïques [PV] comprenant des jonctions multiples, p. ex. des cellules PV en tandem
• H10K 39/15 - Modules photovoltaïques [PV] organiquesRéseaux de cellules PV organiques simples comprenant à la fois des cellules PV organiques et des cellules PV inorganiques
• H10K 85/60 - Composés organiques à faible poids moléculaire
• H10K 30/53 - Dispositifs photovoltaïques [PV] sous forme de fibres ou de tubes, p. ex. fibres photovoltaïques

Abrégé

Self assembling molecules on atomically thin active layers of membranes for use in selective separations are generally described. In one embodiment, a membrane comprises an atomically thin active layer having a plurality of selective pores, wherein a first charged polymer layer and a second charged polymer layer are disposed on opposite surfaces of the atomically thin active layer. In another embodiment, the atomically thin active layer is covalently or non-covalently bonded to the charged polymer layers. In yet another embodiment, selective functional groups on the charged polymer layers are configured to selectively bind ions.

Classes IPC  ?

• B01D 69/12 - Membranes compositesMembranes ultraminces
• B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
• B01D 65/10 - Test de membranes ou d'appareils à membranesDétection ou réparation de fuites
• B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
• B01D 71/02 - Matériaux inorganiques

Abrégé

22). The hydrogen gas can then be reacted with a nitrogen source to form ammonia that can be collected. In alternate embodiments, the nitrogen gas can be pumped into contact with the hydrogen gas released from the rock bed to form ammonium salt in the earth's crust, which can be excavated. In some other embodiments, a catalyst can be transported along with reactants, or a reaction can be facilitated by a catalyst in the rock bed, to form ammonia gas in situ without hydrogen gas formation.

Classes IPC  ?

• C01C 1/04 - Préparation d'ammoniac par synthèse
• B01J 23/745 - Fer
• C01C 1/16 - Halogénures d'ammonium
• C01C 1/26 - Carbonates ou bicarbonates d'ammonium
• E21B 41/00 - Matériel ou accessoires non couverts par les groupes
• E21B 43/00 - Procédés ou dispositifs pour l'extraction de pétrole, de gaz, d'eau ou de matériaux solubles ou fusibles ou d'une suspension de matières minérales à partir de puits

Abrégé

Photonic quantum computation comprises generating n-qubit photonic states, the generating comprising: emitting from a two-dimensional (2D) array of photon emitters, photons that propagate in a direction substantially perpendicular to a first plane over which the 2D array of photon emitters are arranged, and generating the n-qubit photonic states based at least in part on the 2D array of photon emitters; modulating the n-qubit photonic states in a volumetric spatial light modulator (VSLM), the modulating comprising receiving at least a portion of the n-qubit photonic quantum states and generating a distribution of photonic quantum states; generating detection event signals from respective photon detectors distributed over a region that receives a portion of the distribution of photonic quantum states; and controlling at least some modulation applied by the VSLM based at least in part on detection event signals from two or more of the photon detectors.

Classes IPC  ?

• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
• B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron
• G01B 9/02 - Interféromètres
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux

Abrégé

A computer-implemented method for task-guided graph augmentation and editing includes receiving an input graph in an observed financial transaction network. A data augmentation function is learned, where the data augmentation function maintains a true data distribution of the input graph. An augmented financial transaction network is generated that enhances performance of a downstream task and preserves topological and temporal properties of the input graph.

Classes IPC  ?

• G06Q 20/40 - Autorisation, p. ex. identification du payeur ou du bénéficiaire, vérification des références du client ou du magasinExamen et approbation des payeurs, p. ex. contrôle des lignes de crédit ou des listes négatives

Abrégé

The present invention relates to a composition comprising a polyimidazolium (PIM) compound for use in the treatment and/or prevention of mastistis in a mammal, and to methods of use.

Classes IPC  ?

• A61K 31/787 - Polymères contenant de l'azote contenant des hétérocycles ayant l'azote comme hétéro-atome d'un cycle
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61P 31/04 - Agents antibactériens
• C08G 73/06 - Polycondensats possédant des hétérocycles contenant de l'azote dans la chaîne principale de la macromoléculePolyhydrazidesPolyamide-acides ou précurseurs similaires de polyimides

Abrégé

Systems and devices are disclosed for mobility assistance of users with instability or reduced mobility when walking. The mobility device can be a garment (e.g., pants, shorts) that includes a wearable harness embedded or otherwise associated with the garment in a manner that allows the garment to be worn without the harness being outwardly noticeable. The garment can be worn in conjunction with being connected to a walker or other mobility aid vehicle, as well as in everyday use. The harness associated with the garment provides support for the user while a majority of the harness is invisible from outside the garment. A connector can be utilized in conjunction with the same to help manage the connection between the harness and the mobility aid vehicle. The connector can include the ability to mitigate or stop a fall in response to parameters detected by sensors associated with the garment or system.

Classes IPC  ?

• A61H 3/00 - Appareils pour aider des personnes handicapées à marcher

Abrégé

The introduction of low levels of cleavable comonomer additives into existing vinyl polymerization processes may facilitate the production of chemically deconstructable and recyclable variants with otherwise equivalent properties. The present disclosure describes cleavable comonomer approach as a viable strategy toward circular vinyl polymers. The present disclosure describes copolymers comprising m1 instances of the first repeating unit of Formula (i); m2 instances of the second repeating unit of Formula (ii-A) or (ii-B); and optionally one or more types of additional repeating units. The disclosure also provides compounds of the formula: or a tautomer or salt thereof. The present disclosure further describes methods of preparation, compositions, and kits. The introduction of low levels of cleavable comonomer additives into existing vinyl polymerization processes may facilitate the production of chemically deconstructable and recyclable variants with otherwise equivalent properties. The present disclosure describes cleavable comonomer approach as a viable strategy toward circular vinyl polymers. The present disclosure describes copolymers comprising m1 instances of the first repeating unit of Formula (i); m2 instances of the second repeating unit of Formula (ii-A) or (ii-B); and optionally one or more types of additional repeating units. The disclosure also provides compounds of the formula: or a tautomer or salt thereof. The present disclosure further describes methods of preparation, compositions, and kits.

Classes IPC  ?

• C08G 75/045 - Polythioéthers à partir de composés mercapto ou de leurs dérivés métalliques à partir de composés mercapto et de composés insaturés

Abrégé

Systems and methods for active and passive suppression of the transition from laminar to turbulent fluid flow in conduits for fluid transport, which include pipes, channels, and semi-confined passageways. Examples include implementations of a turbulence model that predicts a turbulence transition mode of a fluid within the conduit and systems and methods for modifying the fluid in the conduit to reduce or suppress the predicted turbulence transition mode and thereby prevent or delay transition of the fluid flow from laminar to turbulent. Examples include active and systems to introduce disturbances into the fluid flow that cancel, absorb, or reduce the predicted turbulence transition mode. Examples include conduit liners configured to absorb energy from the fluid flow at a frequency of the predicted turbulence transition mode. Examples include textures and surface geometries configured to transfer energy in the fluid flow from the predicted turbulence transition mode to a different frequency.

Classes IPC  ?

• F16L 55/02 - Absorbeurs d'énergieAbsorbeurs de bruit
• F15D 1/00 - Action sur l'écoulement des fluides
• F15D 1/06 - Action sur l'écoulement des fluides dans les tuyaux ou les conduits en agissant sur la couche-limite

Abrégé

Applications of a Streptococcus Cas9 ortholog from Streptococcus macacae (Smac Cas9), possessing minimal adenine-rich PAM specificity, include an isolated Streptococcus macacae Cas9 protein or transgene expression thereof, a CRISPR-associated DNA endonuclease with PAM interacting domain amino acid sequences that are at least 80% identical to that of the isolated Streptococcus macacae Cas9 protein, and an isolated, engineered Streptococcus pyogenes Cas9 (Spy Cas9) protein with a PID as either the PID amino acid composition of the isolated Streptococcus macacae Cas9 (Smac Cas9) protein or of a CRISPR-associated DNA endonuclease with PID amino acid sequences that are at least 80% identical to that of the isolated Streptococcus macacae Cas9 protein. A method for altering expression of at least one gene product employs Streptococcus macacae Cas9 endonucleases in complex with guide RNA, for specific recognition and activity on a DNA target immediately upstream of either an “NAA” or “NA” or “NAAN” PAM sequence.

Classes IPC  ?

• C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora
• C12N 9/22 - Ribonucléases
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées

Abrégé

A photolithography system with an actuatable reticle stage is disclosed. Mechanical actuators coupled to a long-stroke reticle stage are driven to extend and mechanically contact a short-stroke stage during reticle stage turnaround. The actuators may be piezoelectric stack pushers or pneumatic bellows pushers. The pusher devices are controlled and driven to enable higher acceleration turnaround trajectories by applying forces via mechanical contact engaging during turnaround and disengaging before exposure begins during a scan.

Classes IPC  ?

• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet

Abrégé

Atomic layer deposition for tuning performance of atomically thin active layers for use in membranes and related methods are generally described. In some embodiments, a membrane may include an atomically thin active layer with a plurality of selective pores and a material deposited on the pore edges and/or inside the pores of at least a portion of the plurality of selective pores which may be used to improve a selectivity of the membrane. In certain embodiments, techniques such as atomic layer deposition are used to deposit the material in and/or on at least a first portion of the plurality of selective pores and may reduce the average modified pore size and a pore size variance of the plurality of selective pores.

Classes IPC  ?

• B01D 69/12 - Membranes compositesMembranes ultraminces
• B01D 71/02 - Matériaux inorganiques

Abrégé

Devices and processes to separate a material from a mixture of materials using centrifugal force created by a vortex of air in a separation chamber are provided for. For example, a separation chamber can include a cyclone chamber, a material entry for receiving a mixture of materials and a material exit to collect a first material separated from the mixture of materials. A vortex of air moving vertically upward from an air entry to an air exit creates a centrifugal force that urges the first material with lower density towards a chamber wall and through the material exit while urging the remaining material with higher density towards a central portion of the chamber and out of a separate exit.

Classes IPC  ?

• B04C 5/04 - Entrées tangentielles
• B04C 5/081 - Formes ou dimensions
• B04C 5/13 - Structure du guide pour la phase légère, p. ex. pour faire sortir la matière en spirale ou en la dispersant formé comme un capteur de tourbillon, et s'étendant à l'intérieur de la chambre du tourbillonÉvacuation du viseur de tourbillon autrement que par le haut du cycloneDispositifs de commande de l'évacuation de la phase légère
• B04C 5/14 - Structure du guide pour la phase lourdeStructure de l'apexAménagement d'évacuation
• B04C 9/00 - Combinaisons avec d'autres dispositifs, p. ex. avec des ventilateurs
• B04C 11/00 - Accessoires, p. ex. dispositifs de sécurité ou de commande, non prévus ailleurs
• B07B 7/086 - Séparation sélective des matériaux solides portés par des courants de gaz, ou dispersés dans ceux-ci utilisant la force centrifuge produite par le déplacement du courant de gaz
• B07B 9/02 - Combinaisons d'appareils semblables ou différents, pour séparer les solides, par utilisation de courants de gaz
• B04C 5/30 - Structures de recirculation, à l'intérieur des cyclones ou en coopération avec ceux-ci qui accomplissent une recirculation partielle du milieu, p. ex. au moyen de conduits

Abrégé

Disclosed herein are methods, compositions, systems, and kits related to functional testing of soluble polypeptides in a single-cell format.

Classes IPC  ?

• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• G01N 21/64 - FluorescencePhosphorescence
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

Disclosed are conjugates and methods of identifying ligands for substrates using said conjugates. Also disclosed herein are methods of making the conjugates.

Classes IPC  ?

• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Provided herein are compounds, such as compounds of Formulae (I) and (III), and compositions, methods, uses, and kits thereof. The compounds provided herein are poly(β-amino esters) useful for delivery of agents, such as vitamins and minerals, for the treatment and/or prevention of various diseases and conditions (e.g., micronutrient deficiency).

Classes IPC  ?

• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 31/07 - Composés du rétinol, p. ex. vitamine A
• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
• A61K 31/355 - Tocophérols, p. ex. vitamine E
• A61K 31/375 - Acide ascorbique, c.-à-d. vitamine CSes sels
• A61K 31/455 - Acide nicotinique, c.-à-d. niacineSes dérivés, p. ex. esters, amides
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/525 - Iso-alloxazines, p. ex. riboflavines, vitamine B2
• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3
• A61K 31/714 - Cobalamines, p. ex. cyanocobalamine, vitamine B12
• A61K 33/18 - IodeSes composés
• A61K 33/26 - FerSes composés
• A61K 33/30 - ZincSes composés
• C08G 73/06 - Polycondensats possédant des hétérocycles contenant de l'azote dans la chaîne principale de la macromoléculePolyhydrazidesPolyamide-acides ou précurseurs similaires de polyimides

Abrégé

Removal of gas-evolving species from powders can be achieved before sintering occurs, reducing or eliminating gas evolution in a dense body that can lead to swelling, or lowering of density.

Classes IPC  ?

• B22F 3/10 - Frittage seul
• B22F 1/10 - Poudres métalliques contenant des agents lubrifiants ou liantsPoudres métalliques contenant des matières organiques

Abrégé

Provided herein are fusion proteins comprising antigens (e.g., cancer neoantigens) conjugated to localization domains and/or self-proteins through an amino acid linker sequence that is preferentially cleaved by S-cathepsin, and methods of use thereof.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire

Abrégé

x3-yy72377, new compositions with exceptionally high energy density and low voltage hysteresis can be created.

Classes IPC  ?

• H01M 4/505 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de manganèse d'oxydes ou d'hydroxydes mixtes contenant du manganèse pour insérer ou intercaler des métaux légers, p. ex. LiMn2O4 ou LiMn2OxFy
• C01G 45/12 - Oxydes complexes comprenant du manganèse et au moins un autre élément métallique

Abrégé

The present disclosure relates in some aspects to methods, cells, and compositions for preparing isolated engineered immune cells comprising T cell receptors (TCRs) capable of recognizing a disease-associated antigen. In some aspects, the immune cells are T cells for use in immunotherapy. Provided In an embodiment are T cell preparation methods, including isolation, processing, incubation, and genetic engineering of cells and populations of cells. Also provided are the isolated engineered T cells and compositions produced by the methods in the present disclosure. In some aspects, the methods prepare T cells for adoptive therapy. In an embodiment, the disease-associated antigen is a cancer-associated antigen.

Abrégé

A computer-implemented method and system for generating a predictive model include a computation engine learning a predictive model having missing or crippled data. A processor applies a formulated problem of missing or crippled data based learning to the predictive model. The computation engine reduces one or more tasks associated with the predictive model to a quadratically constrained quadratic problem (QCQP). The computation engine characterizes one or more solutions associated with the QCQP, where each of the one or more solutions is a loss function value.

Classes IPC  ?

• G06N 20/00 - Apprentissage automatique

Abrégé

A method of designing a metal alloy powder having a miscibility gap at low temperature is disclosed. The method includes identifying a first metal element and a second metal to form a metal alloy. selecting a third metal having a miscibility gap with the metal alloy. and mechanically alloying the third metal and the metal alloy to form a metal alloy powder having a nanoscale grain size. The metal alloy powder can be engineered to have a phase separation temperature at which diffusion of the third metal occurs to phase separate as a nanoscale phase. The nanoscale phase can redissolve at a transition temperature higher than the phase separation temperature.

Classes IPC  ?

• C22C 1/10 - Alliages contenant des composants non métalliques
• C22F 1/10 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid du nickel ou du cobalt ou de leurs alliages

Abrégé

Disclosed are compositions comprising a lipid nanoparticle and a modified biomolecular corona. In some embodiments, the modified biomolecular corona comprises a fused cell-specific binding domain. In some embodiments, the modified biomolecular corona protein has been additionally modified such that it does not bind substantially to its natural receptor. In some embodiments, the fused cell-specific binding domain binds to a target cell.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 9/51 - Nanocapsules
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif

Abrégé

Compositions comprising an electronically conductive polymer and a metal-organic framework (MOF), and related sensors and methods of sensing analytes, are generally described.

Classes IPC  ?

• G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de l'absorption d'un fluideRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• H01B 1/12 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisésEmploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques substances organiques
• H01B 1/22 - Matériau conducteur dispersé dans un matériau organique non conducteur le matériau conducteur comportant des métaux ou des alliages

Abrégé

Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 14/54 - Interleukines [IL]
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C12N 15/86 - Vecteurs viraux

Abrégé

Compositions are provided, of the general formula X1-X2-X3, wherein (a)X2 comprises an antigen; (b) X1 is absent or comprises or consists of the amino acid sequence (C)KKKTG (SEQ ID NO: 1); and (c) X3 is absent or comprises or consists of the amino acid sequence GTKKK(C) (SEQ ID NO:2), wherein (i) only one of X1 and X3 is present, and (ii) the residue m parentheses m SEQ ID NO: 1 and SEQ ID NO: 2 is optional and may be present or may be deleted.

Abrégé

In one aspect, a transformer having a primary winding and a secondary winding, the transformer comprises: a plurality of transmission-line cable sections each having at least a first conductor and a second conductor; wherein the first conductors of the transmission-line cable sections are connected in parallel to form the primary winding; and wherein the second conductors of the transmission-line cable sections are connected in series to form the secondary winding. According another aspect, a system for generating bias pulsed waveforms includes: a low-voltage pulse generation stage having an inverter coupled to receive one or more direct current (DC) input voltages; a transformer having a primary winding and a secondary winding; and a controller configured to operate switches of the inverter according to a multi-stage switching sequence to generate bias pulsed waveforms across a primary winding of the transformer.

Classes IPC  ?

• H01F 27/28 - BobinesEnroulementsConnexions conductrices
• H05H 1/46 - Production du plasma utilisant des champs électromagnétiques appliqués, p. ex. de l'énergie à haute fréquence ou sous forme de micro-ondes
• H02M 7/48 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande

Abrégé

Systems and methods are provided for identifying at least one of pre-cancerous or cancerous cells present in a whole organ or tissue of a subject. The method includes preparing the whole organ or tissue of the subject for imaging, exciting the whole organ or tissue of the subject with a beam of light, and acquiring imaging data from the whole organ or tissue of the subject. The method also includes processing the imaging data using a machine learning model to determine a presence of pre-cancerous or cancerous cells in the whole organ or tissue of the subject and generating a report identifying a location of pre-cancerous or cancerous cells in the whole organ or tissue of the subject.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G01J 3/28 - Étude du spectre

Abrégé

Lateral crystal-differentiated and functional-differentiated structures can be grown in a single epitaxial growth step. Such structures can be used to form integrated magnetically- controlled pixels. The pixels can be implemented as magnetooptic pixels for a spatial light modulator. A controlling magnetic flux can be supplied to active elements in each magnetically-controlled pixel by a magnetic conduit comprising a high-permeability material. Several different magnetically-controlled, integrated-circuit devices are possible.

Classes IPC  ?

• G02F 1/00 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire
• B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
• G02F 1/09 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments magnéto-optiques, p. ex. produisant un effet Faraday

Abrégé

Disclosed herein are compositions comprising sterol-amino-phosphate compounds and methods of making and use thereof. Also disclosed herein are methods of making and methods of use of the compounds, compositions, and/or lipid particles disclosed herein. For example, the compounds and compositions are useful for treating a disease or disorder in humans and in animals. In some examples, the subject is a human male and the disease or disorder comprises male infertility.

Classes IPC  ?

• A61K 47/28 - Stéroïdes, p. ex. cholestérol, acides biliaires ou acide glycyrrhétinique
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61P 15/10 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour l'impuissance

Abrégé

Methods involving physics-informed deep learning to help solve inverse problems of solid materials/structures related to unknown geometry include (1) identifying and characterizing unknown materials/structures and defects with accuracy and predictive capability and limited non-destructive measurements, and/or (2) designing geometrical features and parameters of solid materials and structures to achieve optimized and/or improved performance.

Classes IPC  ?

• G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
• G06N 3/08 - Méthodes d'apprentissage
• G16C 60/00 - Science informatique des matériaux, c.-à-d. TIC spécialement adaptées à la recherche des propriétés physiques ou chimiques de matériaux ou de phénomènes associés à leur conception, synthèse, traitement, caractérisation ou utilisation

Abrégé

Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.

Classes IPC  ?

• A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p. ex. séquences de liaison peptidiques vulnérable aux protéases
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

Methods in accordance with the present disclosure include administering a plurality of instances of a learning task to one or more subjects. The one or more subjects provide responses in accordance with the learning task and the responses are then graphed. Decision boundaries associated with the responses provided in each instance may differ between a first instance of the learning task and a second instance of the learning task. A trend is determined between a first decision boundary and a second decision boundary. Based on this trend, one or more of a neurological state, condition or impairment, a cognitive ability, or a cognitive flexibility may be assessed in connection with one or more subjects.

Classes IPC  ?

• A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/378 - Stimuli visuels

Abrégé

The invention, in some aspects includes methods and systems for multiplexed expansion revealing (multiExR), which enables high-fidelity antibody visualization of up to and more than 20 proteins in the same specimen, over serial rounds of staining and imaging.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• C12Q 1/6837 - Couplage enzymatique ou biochimique d’acides nucléiques à une phase solide utilisant des réseaux de sondes ou des puces à sondes
• G01N 21/64 - FluorescencePhosphorescence
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques

Abrégé

Compositions comprising fused aromatic systems and associated electrodes, electrochemical cells, and charge storage devices are generally described. Preferably, the aromatic comprising a bis-tetraamino-benzoquinone molecule and/or a tautomer, oligomer, and/or polymer thereof. Alternatively, the aromatic composition comprises an active material comprising a fused aromatic system comprising carbon atoms, hydrogen atoms, and a plurality of heteroatoms each replacing a carbon atom.

Classes IPC  ?

• H01G 11/58 - Électrolytes liquides
• C07D 241/46 - Phénazines
• H01G 11/48 - Polymères conducteurs
• H01M 4/60 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés organiques

Abrégé

Several new techniques for designing nanophotonic scintillators which lead to optimal performance and novel functionalities. Important design concepts include the use of absorbing structures inspired by solar cells, angularly-selective structures, and metasurfaces. Scintillators based on conventionally overlooked materials (such as GaAs or GaN) are also disclosed, which are designed to reach efficiencies comparable or superior to state-of-the-art conventional scintillators (such as YAG:Ce and LYSO). Such scintillators provide important enhancement of scintillation yield arising from incorporation of nanophotonic patterns. Additionally, nanophotonic scintillators designed in conjunction with image post processing algorithms (such as deconvolution algorithms, tomographic reconstruction, etc.) are disclosed. These scintillators are designed in order to increase robustness, minimize the required dose/scan time or even the number of scans required in scintillation imaging. These new designs optimize the scintillator for optimal reconstruction.

Classes IPC  ?

• G01N 23/04 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux
• B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G21K 4/00 - Écrans de conversion pour transformer une distribution spatiale de particules ou de rayonnements ionisants en images visibles, p. ex. écrans fluorescents

Abrégé

Structural variants of 2D polymers and composites thereof are described.

Classes IPC  ?

• C08G 69/28 - Procédés de préparation
• C08J 5/24 - Imprégnation de matériaux avec des prépolymères pouvant être polymérisés en place, p. ex. fabrication des "prepregs"
• C08K 7/06 - Éléments

Abrégé

Liquid Crystal Elastomer (LCE) fibers, an apparatus for manufacturing, and a method for using the apparatus are provided. LCE fibers formed from each of a plurality of resin recipes can undergo reversible temperature driven actuation of the fiber. Each of the resin recipes forms a fiber having a different actuation temperature. The apparatus includes: an extrusion device, a drawing bobbin, a coating basin, a collector bobbin, a first plurality of curing devices, and a second plurality of curing devices, to transform a resin recipe into a LCE fiber. In operation, the extrusion device extrudes the resin through to the first plurality of curing devices for a partial cure. Once in contact with drawing bobbin the resin is coated in a fluid, and then pull through the second plurality of curing devices for a final cure by collector bobbin, where it can be collected and post-processed.

Classes IPC  ?

• C09K 19/38 - Polymères, p. ex. polyamides
• B01J 27/24 - Composés de l'azote
• B29C 35/08 - Chauffage ou durcissement, p. ex. réticulation ou vulcanisation utilisant l'énergie ondulatoire ou un rayonnement corpusculaire
• B29C 48/00 - Moulage par extrusion, c.-à-d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désiréeAppareils à cet effet
• B29C 48/05 - Moulage par extrusion, c.-à-d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désiréeAppareils à cet effet caractérisées par la forme à l’extrusion de la matière extrudée filamentaire, p. ex. fils
• B29L 31/48 - Vêtements
• C08F 136/02 - Homopolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, l'un au moins contenant plusieurs liaisons doubles carbone-carbone le radical ne contenant que deux doubles liaisons carbone-carbone

Abrégé

Liquid Crystal Elastomer (LCE) fibers, an apparatus for manufacturing, and a method for using the apparatus are provided. LCE fibers formed from each of a plurality of resin recipes can undergo reversible temperature driven actuation of the fiber. Each of the resin recipes forms a fiber having a different actuation temperature. The apparatus includes: an extrusion device, a drawing bobbin, a coating basin, a collector bobbin, a first plurality of curing devices, and a second plurality of curing devices, to transform a resin recipe into a LCE fiber. In operation, the extrusion device extrudes the resin through to the first plurality of curing devices for a partial cure. Once in contact with drawing bobbin the resin is coated in a fluid, and then pull through the second plurality of curing devices for a final cure by collector bobbin, where it can be collected and post-processed.

Classes IPC  ?

• C09K 19/38 - Polymères, p. ex. polyamides
• C09K 19/54 - Additifs n'ayant pas de mésophase spécifique
• B32B 27/02 - Produits stratifiés composés essentiellement de résine synthétique sous forme de fibres ou de filaments
• C08F 2/48 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible

Abrégé

The present disclosure provides site-selective conjugation of a pharmaceutical agent to an antibody using an affinity peptide. The antibody-pharmaceutical agent conjugates may be useful in treating, preventing, or diagnosing diseases in subjects.

Classes IPC  ?

• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs

Abrégé

Methods and systems for the electrochemical epoxidation of alkenes to generate an epoxide are described herein. Said methods and systems comprise: contacting an anode comprising an oxygen atom transfer electrocatalyst with an alkene in the presence of an electrolyte comprising water; applying a voltage to the anode and a cathode to generate the epoxide; wherein the oxygen atom transfer electrocatalyst comprises an at least partially oxidized palladium-platinum alloy characterized by the formula FX1: PdyPtzOx; wherein y is greater than 0 and less than 1; z is greater than 0 and less than 1; wherein the sum of y and z is equal to 1; and x is selected from the range of 0 to 2. The methods and systems disclosed herein comprise a significant advancement in the electrocatalytic epoxidation of alkenes in aqueous and mixed electrolytes using water as the oxygen atom transfer source.

Classes IPC  ?

• C25B 3/07 - Composés contenant au moins un atome d’oxygène
• C25B 3/23 - Oxydation
• C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
• C25B 11/032 - Électrodes à diffusion de gaz
• C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
• C25B 11/065 - Carbone
• C25B 11/075 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’un seul élément catalytique ou composé catalytique

Abrégé

Compositions and methods for forming composites of polymer fibers, yarns, and textiles having enhanced elastocaloric and twistocaloric performance are provided herein. The composites can permit reversible temperature shifts within the materials, and can be used, for example, in energy conversion and thermal storage systems. These composites can be formulated by melt spinning the polymer fibers and using combinations of twisting and stretching of the polymer fibers. The fibers can include, for example, a base polymer that can be amorphous, or substantially amorphous, and desired alignment can occur, for example, by performing one or more of the various provided for techniques. In at least some embodiments, the composite materials can be further enhanced by including one or more phase change materials (PCMs), such as by cross-linking the one or more PCMs with one or more polymers and/or directly attaching the PCM(s) to the polymer(s).

Classes IPC  ?

• D01D 5/10 - Méthodes de filage à partir de masses en fusion utilisant des matières organiques
• D01D 5/098 - Méthodes de filage à partir de masses en fusion avec étirage simultané
• D01F 1/10 - Autres agents modifiant les propriétés de ces filaments
• D01F 6/30 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir de copolymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone comportant des oléfines comme constituant majeur
• D02G 3/44 - Filés ou fils caractérisés par la destination pour laquelle ils ont été conçus