Abstract

The present disclosure relates to an assay method for detection of target nucleic acid. The method includes immobilizing a guide RNA (gRNA) to an immobilization surface; complexing a Cas enzyme to the gRNA; adding a target nucleic acid; labeling the target nucleic acid; detecting the target nucleic acid without amplification; and determining one or more results based on the detected target nucleic acid via a reader.

Goods & Services

Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences.

Goods & Services

(1) Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences.

Goods & Services

Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences.

Goods & Services

Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences.

Goods & Services

Research and scientific research consulting in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences

Goods & Services

(1) Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences.

Goods & Services

(1) Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences.

Goods & Services

Scientific research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences

Goods & Services

Scientific research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences

Abstract

A gas chromatography instrument is provided that is capable of analyzing samples both quickly and accurately. The detector includes a first unit and a second unit that alternate between collection mode and desorption mode. This allows one unit to collect the sample, while the other unit desorbs another sample before the units switch operations. The alternating collection and desorption modes allows the detector to generate a data point approximately every thirty seconds, with each alternating unit.

IPC Classes  ?

• G01N 30/74 - Optical detectors
• G01N 30/54 - Temperature
• G01N 30/06 - Preparation

Abstract

A mobile field-deployable laboratory to more conveniently enable the detecting, sequencing and analyzing of biological agents at the point-of-need. This device enables field operators to go from sample to actionable information in the field without the need for an internet connection or grid-based power. The present mobile laboratory is configured in a footlocker configuration including a plurality of different compartments specifically configured for holding all of the necessary equipment for use in a wide variety of different applications including successfully extracting, amplifying, sequencing and characterizing specific viruses, pathogens and other bacteria directly in the field including an integrated power supply for providing power to the relevant components for up to 72 hours of continuous use without the need for any external power source. The present mobile laboratory includes a deployable workbench area which provides a stable workstation when the footlocker configuration is deployed.

IPC Classes  ?

• A47C 9/00 - Stools for specified purposes
• A45C 5/03 - Suitcases
• A45C 5/04 - TrunksTravelling baskets
• A45C 5/06 - Rigid or semi-rigid luggage with outside compartments
• A47B 3/10 - Travelling or trunk tables

Abstract

Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.

IPC Classes  ?

• C07C 309/73 - Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
• A61P 35/00 - Antineoplastic agents
• C07C 215/10 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions

Abstract

A mobile field-deployable laboratory to more conveniently enable the detecting, sequencing and analyzing of biological agents at the point-of-need. This device enables field operators to go from sample to actionable information in the field without the need for an internet connection or grid-based power. The present mobile laboratory is configured in a footlocker configuration including a plurality of different compartments specifically configured for holding all of the necessary equipment for use in a wide variety of different applications including successfully extracting, amplifying, sequencing and characterizing specific viruses, pathogens and other bacteria directly in the field including an integrated power supply for providing power to the relevant components for up to 72 hours of continuous use without the need for any external power source. The present mobile laboratory includes a deployable workbench area which provides a stable workstation when the footlocker configuration is deployed.

IPC Classes  ?

• B01L 9/02 - Laboratory benches or tablesFittings therefor
• A45F 4/02 - Sacks or packs convertible into other articles
• C12Q 1/686 - Polymerase chain reaction [PCR]
• A45F 3/04 - Sacks or packs carried on the body by means of two straps passing over the two shoulders
• A45C 5/04 - TrunksTravelling baskets
• B01L 1/00 - EnclosuresChambers
• A45C 5/14 - Rigid or semi-rigid luggage with built-in rolling means
• A45C 7/00 - Collapsible or extensible luggage, bags or the like
• A45F 3/00 - Travelling or camp articlesSacks or packs carried on the body
• A45C 9/00 - Luggage or bags convertible into objects for other use

Abstract

Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.

IPC Classes  ?

• A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.

IPC Classes  ?

• A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
• A61P 35/00 - Antineoplastic agents

Goods & Services

Research and analysis in the fields of economics and business management services Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences

Abstract

The high temperature/high pressure (HTHP) reactor of the present invention includes a main cylinder, a reversible piston inside the cylinder that divides the main cylinder into a pressurization chamber and a reactor chamber, a thermal jacket, a lid and an end cap, wherein the HTHP reactor is configured to facilitate microbial growth in the reactor chamber that provides high temperature and high pressure conditions that simulate resource reservoir conditions, wherein the resource may be an oil reservoir. The HTHP chamber of the present invention is also configured to allow the use of a variety of instrumentation and valves that can be customized to allow a user to monitor desired physical properties within the reaction chamber and the microbial behavior and byproducts. This information is used to create an individual treatment plan for a reservoir to maximize the resource recovery, for example during Microbiobial Enhanced Oil Recovery (MEOR).

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology

Goods & Services

Research and consultation in the field of economics and business management services Research and consultation in the fields of physical sciences, biological sciences, mathematics, engineering sciences and chemical sciences

Goods & Services

Providing facilities for scientific research in the nature of solar energy and renewable resources; consulting services for conducting research relating to renewable energy; research in the field of renewable energy and solar energy

Goods & Services

RESEARCH AND CONSULTATION IN THE FIELDS OF THE PHYSICAL SCIENCES, BIOLOGICAL SCIENCES, ENGINEERING SCIENCES, AND ECONOMICS AND MANAGEMENT SCIENCES