Abstract

A heliostat includes a reflector that has at least one segment arranged in a segment assembly and that defines a reflecting surface; a rigid spaceframe structure that includes a plurality of struts joined at nodes, the plurality of struts supporting the segment assembly so as to hold the reflecting surface in a concave toroidal shape; a dual-axis mount constructed and arranged to support and orient the rigid spaceframe structure and the segment assembly so as to reflect sunlight incident on the reflecting surface toward a distant receiving surface, the dual-axis mount including at least two drives; at least one mechanical linkage coupled to at least one drive of the dual-axis mount and configured to change a relative position of at least two nodes of the rigid spaceframe structure in synchronization with motion of the at least one drive, and thereby changing a shape of the rigid spaceframe structure and the reflector.

IPC Classes  ?

• G02B 7/183 - Mountings, adjusting means, or light-tight connections, for optical elements for prismsMountings, adjusting means, or light-tight connections, for optical elements for mirrors for mirrors specially adapted for very large mirrors, e.g. for astronomy
• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 23/74 - Arrangements for concentrating solar rays for solar heat collectors with reflectors with trough-shaped or cylindro-parabolic reflective surfaces
• F24S 30/45 - Arrangements for moving or orienting solar heat collector modules for rotary movement with two rotation axes
• G02B 5/10 - Mirrors with curved faces
• G02B 19/00 - Condensers
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light

Abstract

An optical biasing system that injects a synthetic light field into the path provided to an event-based sensor, shifting irradiance levels from low-light regions (where noise events are common) to a higher brightness region with more stable noise rates. In some embodiments, the optical biasing system determines the ambient brightness level of the captured scene and outputs a synthetic (e.g., a temporally varying) light field having an irradiance level selected to optimize the signal-to-noise ratio at the determined ambient brightness level. In some embodiments, the optical biasing system determines the ambient brightness level at each pixel and outputs a light field having spatially varying irradiance levels to optimize the signal-to-noise ratio of each pixel. The disclosed system provides a number of benefits over existing EBS noise correction methods, most notably because the disclosed method does not require modifying sensor hardware or using active algorithms to control sensor parameters.

IPC Classes  ?

• H04N 5/21 - Circuitry for suppressing or minimising disturbance, e.g. moire or halo

Abstract

SARS-CoV-2 has caused a global pandemic with significant humanity and economic loss since the beginning of 2020. Flaviviruses such as Zika and Dengue viruses are also significant human pathogens. Although SARS-CoV-2 vaccines are effective in preventing severe disease outcomes, they are less effective in controlling infection or re-infection, particularly due to rapid evolution of viral variants of SARS-CoV-2. Currently only limited options are available to treat SARS-CoV-2 and flavivirus infections for vulnerable populations. Potential of a future pandemic of other viruses is high. The present invention features compositions and methods for a universal high throughput screening (HTS) assay to identify inhibitors targeting the S-adenosyl-L-methionine (SAM)-binding site of viral methyltransferases (MTases) using SAM as a methyl donor.

IPC Classes  ?

• A61K 31/12 - Ketones
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61P 31/14 - Antivirals for RNA viruses
• C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase

Abstract

Methods and systems for the automated generation of test coverage metrics for microservice systems are disclosed. An example method for generating test coverage metrics for a test suite comprising multiple tests for a microservice system containing multiple microservices includes generating a first set of endpoints associated with the multiple microservices based on a static analysis of the corresponding microservice source code and a second set of endpoints based on generating traces and capturing interactions during operation of the corresponding microservice. The method further includes integrating the first and second sets of endpoints to generate a combined set of endpoints, and determining, based thereon, the test coverage metrics for the multiple tests. The method then reconfigures, based on the test coverage metrics, at least one of the multiple tests or at least one of the multiple microservices. An example system includes one or more processors configured to implement the above-described method.

IPC Classes  ?

• G06F 11/3668 - Testing of software
• G06F 11/34 - Recording or statistical evaluation of computer activity, e.g. of down time, of input/output operation
• G06F 8/75 - Structural analysis for program understanding
• G06F 11/00 - Error detectionError correctionMonitoring

Abstract

A composition for treating inflammatory, neoplastic and obstructive lung diseases featuring a CC16-derived analog is described herein. The analog may include N-terminal acetylation and C -terminal amidation, enhancing stability. Adopting a helical conformation, the CC16-derived analog maintains activity akin to full-length CC16 protein. Effective for diverse lung diseases, the composition allows aerosolization, subcutaneous injection, and pulmonary delivery, with administration options including nasal inhalation, subcutaneous, or oral routes. A method for treating these diseases involves administering the CC16-derived analog to a subject in need. This innovation offers a versatile, efficacious solution for respiratory conditions, providing tailored treatment approaches.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 19/00 - Hybrid peptides
• A61P 35/00 - Antineoplastic agents

Abstract

Methods, devices and systems are described that reduce polarization aberration of a metal coated surface. An example optical device includes a multi-layer structure that includes a reflective layer having retardance and diattenuation over a particular range of wavelengths. The multi-layer structure also includes a uniaxial birefringent layer positioned above the reflective layer, and an anti-reflection layer positioned above the uniaxial birefringent layer. The uniaxial birefringent layer's thickness is selected to compensate for at least a portion of the retardance of the reflective layer over the particular range of wavelengths. The anti-reflection layer's thickness is selected to compensate for at least a portion of the diattenuation associated with the reflective layer over the particular range of wavelengths. The uniaxial birefringent layer can be a C-plate, and example reflective layers include an aluminum layer, a silver layer or a gold layer.

IPC Classes  ?

• G02B 5/30 - Polarising elements
• G02B 1/116 - Multilayers including electrically conducting layers
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

This present disclosure is directed to a method of treating mining tailings from mining operations using dust suppression composition disclosed herein.

IPC Classes  ?

• E21F 5/06 - Fluids used for spraying
• C09K 3/22 - Materials not provided for elsewhere for dust-laying or dust-absorbing

Abstract

(i.e.(i.e., realtime) size exclusion chromatography (SEC) operably linked to a charge detection mass spectrometer. The apparatuses contain a device—microcontroller—specifically configured to deliver pulsed injections from a large sample loop onto an SEC for online charge detection-mass spectrometry (CD-MS) analysis. Data showed a series of peaks spaced according to the pseudorandom injection sequence, which were demultiplexed with a Hadamard transform algorithm. The demultiplexed data revealed improved CD-MS signals while preserving the retention time information. This multiplexing approach provides a general solution to the inherent incompatibilities of online separations and CD-MS detection, and can be used in a range of applications.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• G01N 30/20 - Injection using a sampling valve
• G01N 30/86 - Signal analysis

Abstract

A dynamic foot brace device for providing arch support to a foot of a user through energy storage at an ankle of the user during a step. The device includes a tension member including a first end coupled to an arch of the foot and a second end coupled to the ankle. The tension member may be configured to store energy from tension applied to the first end during a first phase of the step and release the energy to the foot as a propulsion force when the tension applied to the first end is released during a second phase of the step.

IPC Classes  ?

• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

Endometrial cancer (EC) is the most common gynecologic cancer in developed countries and the fourth most common cancer affecting women in the US. In contrast to other cancers, rates of EC continue to rise, and there are indications that social determinants of health and race and/or ethnicity contribute to risk. Thus, the methods described herein provide a non-invasive means of measuring biomarkers in the local cervicovaginal microenvironment. These novel biomarkers may be used for diagnosing and/or predicting women who are "at risk" for the development and progression of endometrial cancer (EC; e.g., EC type 1). Specifically, the methods herein may include obtaining a cervicovaginal lavage (CVL) or vaginal swab sample from a patient and producing a profile of at least five or more biomarkers from the collected sample.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

Pathogens developing resistance to available drugs are of main concern in various diseases, including cryptococcosis and tuberculosis. Hence there is a need for therapeutics with novel mechanisms of action. Described herein are compositions and methods for treating infections (e.g., fungal infections) caused by microbes (e.g., fungi) comprising inteins. An intein is a moving protein element inside a host protein. Splicing off intein from the host protein is required to maturate and activate the host protein. Calcimycin (CMN) is used as an intein splicing inhibitor to block intein splicing of the Prp8 protein of fungal pathogen C. neoformans and C. gattii the causative agents of cryptococcosis, to treat patients.

IPC Classes  ?

• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61P 31/10 - Antimycotics

Abstract

SARS-CoV-2 has raised the alarm to search for effective therapy for this virus. To date several vaccines have been approved, but few available drugs reported recently still need approval from FDA. Antiviral compositions having niclosamide derivatives were prepared for treating COVID-19. Using a FRET-based enzymatic assay, three niclosamide derivatives, JMX0286, JMX0301, and JMX0941, were identified as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values similar to that of known covalent inhibitor boceprevir. In a cell-based antiviral assay, these inhibitors can inhibit the virus growth with EC50 in the range of 2-3 μM. The mechanism of action of JMX0286, JMX0301, and JMX0941 were characterized by enzyme kinetics, affinity binding and protein-based substrate digestion. Molecular docking suggested that JMX0286, JMX0301, and JMX0941 bind specifically to an allosteric pocket of the SARS-CoV-2 3CL protease.

IPC Classes  ?

• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Three-dimensional (3D) printing methods, systems and devices are described that enable high speed printing of multiple objects using two or more objective lenses and with a large field of view. One example optical system for 3D laser printing includes one or more beamsplitters that are configured to receive a collimated optical laser beam and to produce a plurality of optical beams. The optical system also includes a plurality of objective lenses, each positioned to receive one of the plurality of optical beams, and to focus the received optical beam onto a focal plane that is shared by all of the plurality of objective lenses. The focal plane coincides with a position of 3D printable material, and upon illumination of the 3D printable material by the beams received from the plurality of objective lenses, a plurality of 3D-printed objects are simultaneously generated.

IPC Classes  ?

• B23K 26/067 - Dividing the beam into multiple beams, e.g. multi-focusing
• B23K 26/08 - Devices involving relative movement between laser beam and workpiece
• B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• B28B 1/00 - Producing shaped articles from the material

Abstract

Hyperspectral imaging methods, devices and systems are described that improve the hyperspectral accuracy, and reduce manufacturing costs, by using two images that enable the recovery of hyperspectral images with high fidelity. One hyperspectral imaging device includes one or more imaging lenses, one or more sensors positioned to receive light associated with an object from the one or more imaging lenses, and a spectral filter. The hyperspectral imaging device is configured to capture a first image produced without using the spectral filer and to capture a second image produced with the spectral filter. The first image and the second image have different spectral contents, and the first and the second images are processed using a trained neural network for producing hyperspectral imaging data associated with the first and second images.

IPC Classes  ?

• H04N 23/16 - Optical arrangements associated therewith, e.g. for beam-splitting or for colour correction
• G06T 7/00 - Image analysis
• H04N 23/45 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from two or more image sensors being of different type or operating in different modes, e.g. with a CMOS sensor for moving images in combination with a charge-coupled device [CCD] for still images
• H04N 23/56 - Cameras or camera modules comprising electronic image sensorsControl thereof provided with illuminating means
• H04N 23/74 - Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
• H04N 23/84 - Camera processing pipelinesComponents thereof for processing colour signals

Abstract

Example systems and methods for radio-frequency adversarial deep-learning inference for automated network coverage estimation include a generative adversarial network (GAN) based approach for synthesizing RF maps in indoor scenarios. In some examples, a semantic map is utilized—a high-level representation of the indoor environment to encode spatial relationships and attributes of objects within the environment and guide the radio frequency (RF) map generation process. A new gradient-based loss function is introduced that computes the magnitude and direction of change in RSS values from a point within the environment. Some examples incorporate this loss function along with the antenna pattern to capture signal propagation within a given indoor configuration and generate new patterns under new configuration, antenna (beam) pattern, and center frequency.

IPC Classes  ?

• H04W 48/16 - DiscoveringProcessing access restriction or access information
• G06N 3/0475 - Generative networks
• H04B 17/318 - Received signal strength
• H04W 24/02 - Arrangements for optimising operational condition

Abstract

Methods and compositions for modulating, e.g., damping, contractile oscillations by targeting and/or mimicking My BP-C in heart and skeletal muscles, including therapeutics (e.g., small molecules, peptides, enzymes, antibodies, oligonucleotides, etc.) designed to directly target contractile oscillations and/or MyBP-C. The present invention also includes methods of treating cardiac arrhythmias and/or skeletal muscle tremors by modulating/damping contractile oscillations. e.g., by targeting and/or mimicking My BP-C in the appropriate muscles (e.g., heart, skeletal muscle).

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The methods described herein can be used to produce constructs that are stronger and more resilient when subjected to repeated cyclic loading. The constructs can be formed by fabricating the construct in its mid-point conformation, and then repositioning the construct in its deployment conformation. Alternatively or additionally, the constructs can be formed with additional polymeric material and/or metals added in particular locations that correspond with the pattern of principal stress distribution when the construct is in use. Alternatively or additionally, the constructs can be formed with a plurality of fibers or metal particles embedded therein, where the fibers/particles are oriented in the direction(s) of major load(s) that are applied to the construct during use. Also described are constructs formed by the methods described above. The constructs are used in devices, medical implants, plastic flaps, tubing and/or pipes, and/or the wings of an airplane that are subjected to repeated cyclic loading.

IPC Classes  ?

• B29C 70/54 - Component parts, details or accessoriesAuxiliary operations
• B29C 51/12 - Shaping by thermoforming, e.g. shaping sheets in matched moulds or by deep-drawingApparatus therefor of articles having inserts or reinforcements
• B29C 51/42 - Heating or cooling
• B29C 70/56 - Tensioning reinforcements before or during shaping
• B29K 1/00 - Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material
• B29K 71/00 - Use of polyethers as moulding material
• B29K 75/00 - Use of polyureas or polyurethanes as moulding material

Abstract

Exemplary materials, methods and techniques disclosed and contemplated herein generally relate to the photochemical synthesis of various deuterated 3-formyl indoles using deuterated glyoxylic acid (CDOCO2D).

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound

Abstract

An ultraviolet (UV)-curable composition. The composition includes a first precursor compound comprising more than one alkene groups and a second precursor compound including more than two thiol groups. The first precursor compound may consist of carbon, hydrogen, and optionally sulfur. The second precursor compound may consist of carbon, hydrogen, and sulfur. The composition may be used to form the polymeric material into substrates via 3D printing and UV-curing.

IPC Classes  ?

• C08F 2/48 - Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
• C08F 8/34 - Introducing sulfur atoms or sulfur-containing groups
• C08G 75/02 - Polythioethers
• C08K 5/00 - Use of organic ingredients
• B33Y 80/00 - Products made by additive manufacturing

Abstract

Modular systems tailored for vertical farming in bodies of water provide a versatile solution for crop cultivation. They encompass an undersea module and/or an above-sea module, offering versatility for independent use or seamless integration when combined. The undersea module has a modular frame and a plurality of growth components, including Growing Boards (G-Boards) and Growing Cages (G-Cages). The above-sea module features a frame, a plurality of growth components, and an enclosure for environmental control. The configuration of each of the modules enables ease of installation, maintenance, and harvesting. Combined, these modular systems offer an integrated approach to vertical farming, fostering efficiency and sustainability.

IPC Classes  ?

• A01K 61/00 - Culture of aquatic animals
• A01D 44/00 - Harvesting of underwater plants, e.g. harvesting of seaweed
• A01G 31/02 - Special apparatus therefor
• A01G 31/06 - Hydroponic culture on racks or in stacked containers
• A01G 33/00 - Cultivation of seaweed
• A01K 61/54 - Culture of aquatic animals of shellfish of bivalves, e.g. oysters or mussels
• A01K 80/00 - Harvesting oysters, mussels, sponges or the like

Abstract

Methods, devices and systems are described that enable generation of images with enhanced resolution and/or enhance dynamic range. The described systems eliminate the need to laterally shift the system components, or in some systems, any shift all, and instead utilize multiple exposures made at different magnifications, zoom settings, and/or aperture settings to produce images with higher resolution and/or dynamic range. One example method includes acquiring a plurality of images where each image is acquired at a particular magnification factor different than other acquired images. Each of the acquired images is processed to obtain one or more parameters, functions or modified images, and then the images are combined based on the one or more parameters, functions or modified images to obtain an enhanced-resolution image having a resolution that is higher than a resolution of each of acquired images.

IPC Classes  ?

• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 5/92 - Dynamic range modification of images or parts thereof based on global image properties

Abstract

The present disclosure provides an unmanned vehicle system that includes: a first non-terminal cell enclosing a first plurality of terminal cells, each of the first plurality of terminal cells enclosing a respective unmanned arial vehicle (UAV); a second non-terminal cell enclosing a second plurality of terminal cells, each of the second plurality of terminal cells enclosing a respective UAV; a first non-terminal cell linkage member fixedly coupled to the first non-terminal cell; a second non-terminal cell linkage member movably coupled to the second non-terminal cell; and a non-terminal cell pivot joint to pivotally couple the first and second non-terminal cell linkage members; wherein the first and second non-terminal cells are arranged in a single plane, and first and second non-terminal cell linkage members and the non-terminal cell pivot joint provide controllable movement of the first and second non-terminal cells with respect to one another and within the single plane.

IPC Classes  ?

• B64U 10/14 - Flying platforms with four distinct rotor axes, e.g. quadcopters
• B64U 20/30 - Constructional aspects of UAVs for safety, e.g. with frangible components
• B64U 30/299 - Rotor guards

Abstract

Disclosed are systems and methods for implementing quantum-like gate operation using logical phi-bits of a quantum analogue system for achieving controllable classical entanglement. A method can include driving an array of elastically coupled acoustic waveguides using a first frequency and a second frequency different from the second frequency. A plurality of logical phi-bits can be determined based on acoustic field measurements associated with the waveguides. A tuning parameter value associated with a selected set of logical phi-bits can be determined, wherein the tuning parameter value is associated with a unitary transformation of a state of the selected set of logical phi-bits. A unitary gate operation can be implemented for the selected set of logical phi-bits by tuning an external driver coupled to a particular acoustic waveguide of the array by using the tuning parameter value to adjust one or more of the first frequency or the second frequency.

IPC Classes  ?

• H03K 19/195 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits using specified components using superconductive devices

Abstract

Disclosed are systems and methods for scalable, large, multiple logical phi-bit quantum analogue system for achieving controllable classical entanglement (e.g., nonseparability). A method can include driving an array of elastically coupled acoustic waveguides by exciting at least a first acoustic waveguide of the array using a first frequency and a second acoustic waveguide of the array using a second frequency, wherein the first frequency is different from the second frequency. A plurality of acoustic fields propagating through the array of elastically coupled acoustic waveguides can be determined, each respective acoustic field generated based on the driving of the array using the first and second frequencies. A plurality of logical phi-bits can be determined based on spectrally partitioning the one or more acoustic fields, wherein each logical phi-bit of the plurality of logical phi-bits is associated with at least two independently measurable phases.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

Polymeric heart valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. The polymeric leaflets are designed to possess variable thickness throughout and typically are formed having a semi-open profile to reduce stress. Methods of making and using such polymeric heart valve systems are also described.

IPC Classes  ?

• A61F 2/24 - Heart valves

Abstract

A device for generating forces or motions in accordance with sensor data. The device includes one or more compliant mechanism units and an electromagnetic actuator configured to actuate each compliant mechanism unit. By actuating a compliant mechanism unit using an electromagnetic actuator, the device can generate a force or motion in accordance with received sensor data using hardware components that are much smaller than the servo motors used in existing systems. In various embodiments, the device may actuate one or more compliant mechanism units to control the shape of a haptic meta-surface, activate and deactivate microswitches, open and close microfluidic channels, etc. In various embodiments, the device may actuate one or more compliant mechanism units in accordance with pixel values extracted from light detection and ranging (LiDAR) data, two-dimensional image data, or other sensor data.

IPC Classes  ?

• G05D 15/01 - Control of mechanical force or stressControl of mechanical pressure characterised by the use of electric means
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

A human 2D patient-derived organoid screening platform to study tissue patterning and kinase pathway dynamics in single cells. With the help of this system, it is discovered that waves of ERK signaling induced by apoptotic cells play a critical role in maintaining tissue patterning and homeostasis.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

Artificial polymeric valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. The valve systems described can include supportive frames which have at least one non-circular cross-section with polymeric leaflets that are symmetrical or asymmetrical. The leaflets can also have variable thicknesses. Methods of making and using such artificial polymeric valve systems are also described.

IPC Classes  ?

• A61F 2/24 - Heart valves

Abstract

A multi-layer niosome nanocarrier drug composition for optimized drug delivery is described herein. The composition comprises chloroform extract of mint, Kaempferol Iodine-127 in the inner layer, and fulvic acid in the outer layer of the niosome. The method of preparing the composition is also described herein and may involve dissolving components in chloroform and incubating kaempferol-iodine-loaded niosomes in fulvic acid. The process ensures efficient drug release and enhanced therapeutic efficacy.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 36/16 - Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
• A61K 36/534 - Mentha (mint)
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Photonic quantum computation comprises generating n-qubit photonic states, the generating comprising: emitting from a two-dimensional (2D) array of photon emitters, photons that propagate in a direction substantially perpendicular to a first plane over which the 2D array of photon emitters are arranged, and generating the n-qubit photonic states based at least in part on the 2D array of photon emitters; modulating the n-qubit photonic states in a volumetric spatial light modulator (VSLM), the modulating comprising receiving at least a portion of the n-qubit photonic quantum states and generating a distribution of photonic quantum states; generating detection event signals from respective photon detectors distributed over a region that receives a portion of the distribution of photonic quantum states; and controlling at least some modulation applied by the VSLM based at least in part on detection event signals from two or more of the photon detectors.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• G01B 9/02 - Interferometers
• G02B 27/10 - Beam splitting or combining systems

Abstract

A system and method for real-time, simultaneous, and adaptive beam steering into multiple regions of interest replaces conventional raster scanning, where only regions of interest are scanned by a laser or other optical beam. CUDA-OpenGL interoperability with a computationally time-efficient computer-generated hologram (CGH) calculation algorithm enables such beam steering by employing a phase-spatial light modulator (SLM). The real-time CGH generation and display algorithm is incorporated into the beam steering system with variable power and scan resolution, which are adaptively controlled by camera-based object recognition.

IPC Classes  ?

• G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light

Abstract

Adenomyosis is a highly prevalent yet enigmatic disease that can be diagnosed only via histopathology among women undergoing hysterectomy, thus, leading to underdiagnosis. Unfortunately, research on adenomyosis has been limited due to a variety of challenges, and little work has been done on non-invasive diagnostics for adenomyosis. Currently, there is no FDA-approved non-invasive method for early detection of adenomyosis. By integrating immunoassays and metabolomics analyses, candidate biomarkers for the non-invasive diagnosis of adenomyosis in cervicovaginal lavages have been identified. Thus, methods for non-invasive diagnostic, screening, and early detection of adenomyosis in patients are described herein.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A nitric oxide detector includes a vessel defining a gas chamber therein; an optical resonator disposed in the gas chamber, the optical resonator having a whispering-gallery mode of resonance; an optical source arranged at least one of proximate the vessel or within the gas chamber to provide light to be coupled into the optical resonator to thereby excite the whispering-gallery mode of resonance; and an optical detector arranged at least one of proximate the vessel or within the gas chamber to receive light to be coupled out of the optical resonator to provide a detection signal.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
• G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
• G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

Abstract

This disclosure relates to uses of fumaric acid, fumaric acid esters, dimethyl fumarate, monomethyl fumarate ester, salt, or derivatives thereof by pulmonary administration in the treatment, prevention, or reversal of fibrosis e.g., pulmonary fibrosis, idiopathic pulmonary fibrosis (IPF). In certain embodiments, this disclosure relates to treating a subject with fumaric acid, fumaric acid esters, dimethyl fumarate, monomethyl fumarate ester, salt, or derivatives inhibiting TGF-mediated pro-fibrotic phenotypes. In certain embodiments, the subject is a human of an advanced age.

IPC Classes  ?

• A61K 31/225 - Polycarboxylic acids
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

An optical architecture for enhancing phase modulation depth for a phase light modulator includes a laser light source, a 4f, 1:1 relay where a tilted mirror with a center hole is placed at the backfocal point of the first lens. A vertically polarized (VP) and collimated light is deflected by a polarized beam splitter (PBS), followed by passing through a Quarter Wave Plate (QWP) that converts linear polarization (LP) to right circular polarization (RCP). Upon interaction of the RCP light with PLM, spatial phase is modulated by 2kd(i,j). PLM reflects and modulates phase of light while changing the handness of polarization from RHP to left hand circular polarization (LCP). The 2nd interaction with QWP changes polarization of light from LCP to horizontally polarized (HP) light. The mirror M1 is placed at a half of the Talbot distance from the PLM as described later. The reflected light by M1 is a HP light, therefore it goes through the PBS and is converted to RCP by the 3rd interaction with QWP. Finally the light is modulated by the PLM with the same phase modulation profile and reflected to the direction along the incident laser beam via QWP and PBS. After the laser beam is doubly modulated, the laser beam diffracted towards direction defined by the CGH pattern displayed on PLM. The diffracted beam is reflected by the mirror placed in the 4f 1:1 collimating optics followed by a collimating optics for beam steering.

IPC Classes  ?

• G02B 26/06 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising

Abstract

A composition containing 3-hydroxyanthanilic acid (3HAA) and a compound that alters iron homeostasis (an iron chelator or an iron supplement). The combination may be used as a new antibiotic drug. Combining 3HAA with iron chelation may have the dual benefit of inhibiting pathogen growth while repressing the pathological hyperinflammatory response in septic individuals. The combination may be effective at preserving food by preventing bacterial growth.

IPC Classes  ?

• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A23B 2/762 - Organic compounds containing nitrogen
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 33/26 - IronCompounds thereof
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 31/04 - Antibacterial agents

Abstract

In one aspect, the disclosure relates to small molecules useful as inhibitors of Pim and mTOR protein kinases, pharmaceutical compositions comprising the same, and methods of treating cancers associated with phosphorylation of protein Enhancer of Decapping 3 (EDC3) including, but not limited to, prostate cancer, as well as other cancers in which Pim and mTOR protein kinases are implicated, using the same. Also disclosed are combination therapies including at least one disclosed small molecule inhibitor and at least one AKT inhibitor.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/4704 - 2-Quinolinones, e.g. carbostyril
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07D 215/227 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Abstract

The present invention provides methods and kits a) for preventing and/or treating neuroblastoma (e.g., high-risk neuroblastoma) that is linked, in part, to high levels of ODC activity and increased cellular polyamine content, b) for predicting cancer patient survival, especially cancer patients whose cancer is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and c) for selecting treatment options for such patients based on the allelic nucleotide sequence or SNP at positions +263 and/or +316 of the ODC1 gene. The invention also provides, cancer treatment methods comprising the determination of the ODC1 genotype at the +263 and/or +316 positions, as a means to guide treatment selection, which includes, in some aspects the administration of pharmaceutically effective amounts of α-difluoromethylornithine (DFMO), either as a monotherapy or in combination with one or more other drugs. In addition, the present invention provides methods for preventing and/or treating patients that have been determined to have cancer stem cells, such as patients in cancer remission that are at risk for relapse.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/203 - Retinoic acids
• A61K 31/415 - 1,2-Diazoles
• A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
• A61K 31/69 - Boron compounds
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

IPC Classes  ?

• C07K 5/117 - Tetrapeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp
• A61K 38/34 - Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/68 - Melanocyte-stimulating hormone [MSH]
• C07K 14/72 - ReceptorsCell surface antigensCell surface determinants for hormones

Abstract

In accordance with a method of forming a waveguide in a polymer film disposed on a substrate, a plurality of regions on a polymer film are selectively exposed to a first dosage of radiation. The polymer film is formed from a material having a refractive index that decreases by exposure to the radiation and subsequent heating. At least one region of the polymer film that was not previously exposed to the radiation is selectively exposing to a second dosage of radiation. The second dosage of radiation is less than the first dosage of radiation. The polymer film is heated to complete curing of the polymer film.

IPC Classes  ?

• G02B 6/138 - Integrated optical circuits characterised by the manufacturing method by using polymerisation
• B29D 11/00 - Producing optical elements, e.g. lenses or prisms

Abstract

A high-output bubbling sprinkler device. The device may comprise an adapter configured to be fluidly coupled to a pipe such that water flowing through the pipe is directed through the adapter. The device may further comprise a nozzle fluidly coupled to the adapter, configured to accept water from the adapter. The device may further comprise a hollow dome component fluidly coupled to the nozzle, configured to accept the water from the nozzle such that the water is directed to an inner surface of the hollow dome component, and evenly distribute the water such that an area around the sprinkler device is evenly watered.

IPC Classes  ?

• A01G 25/02 - Watering arrangements located above the soil which make use of perforated pipe-lines or pipe-lines with dispensing fittings, e.g. for drip irrigation
• B05B 13/02 - Means for supporting workArrangement or mounting of spray headsAdaptation or arrangement of means for feeding work
• A62C 35/68 - Details, e.g. of pipes or valve systems
• B05B 15/658 - Mounting arrangements for fluid connection of the spraying apparatus or its outlets to flow conduits the spraying apparatus or its outlet axis being perpendicular to the flow conduit

Abstract

A framework that brings together application development, resource management, and accelerator design into a single compilation and runtime toolchain. In one example aspect, a method for enabling execution of multiple software applications on an embedded system includes receiving a first invocation of an Application Programing Interface (API) function by a first software application and a second invocation of the API function by a second software application, and determining available computing resources corresponding to the API function. The method includes selecting, based on one or more characteristics associated with the available computing resources, a first set of computing resources and a second set of computing resources. The method also includes scheduling the first invocation of the API function using the first set of computing resources and scheduling the second invocation of the API function using the second set of computing resources.

IPC Classes  ?

• G06F 8/41 - Compilation
• G06T 1/20 - Processor architecturesProcessor configuration, e.g. pipelining
• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead
• G06F 13/00 - Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
• G06F 15/78 - Architectures of general purpose stored program computers comprising a single central processing unit

Abstract

A framework that brings together application development, resource management, and accelerator design into a single compilation and runtime toolchain. In one example aspect, a platform for deploying a software application on an embedded system that comprises multiple types of processing elements includes a set of Application Programing Interface (API) functions; a set of program modules each comprising hardware-specific implementation of the set of API functions corresponding to one of the multiple types of processing elements; and a compiler. The compiler is configured to receive a set of instructions representing the software application, generate a binary object by compiling the set of instructions to link to at least part of the set of program modules that corresponds to one or more target types of processing elements.

IPC Classes  ?

• G06F 8/41 - Compilation
• G06T 1/20 - Processor architecturesProcessor configuration, e.g. pipelining
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead
• G06F 13/00 - Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
• G06F 15/78 - Architectures of general purpose stored program computers comprising a single central processing unit

Abstract

Methods, devices and systems are described that enable identification of cancerous or pre-cancerous colon tissue. The described methods and systems rely on non-imaging. randomly sampled second harmonic generation (SHG) intensity measurements that are sufficient for differentiating between tumor and normal tissue. The disclosed methods and system further provide for angle-resolved SHG measurements associated with forward and backward scattered light that eliminate the need to obtain paired normal and cancer-suspicious measurements in each patient using the described techniques.

IPC Classes  ?

• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
• A61B 1/005 - Flexible endoscopes
• A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Methods, devices and systems for characterizing polarization components are described. One example method includes illuminating an area of the polarization component with a uniform light beam in a particular polarization state, and receiving, at a pixelated detector, reflected or transmitted light from the polarization component in response to illuminating the area of the polarization component. Each group of pixels of the pixelated detector receives light from a corresponding spatial region of the polarization component to allow a plurality of spatial regions of the polarization component to be measured in via a single image. The method also includes obtaining Stokes parameters of the polarization component based on the received light at the pixelated detector, and determining one or more characteristics of the polarization component for each of the plurality of the spatial regions using the Stokes parameters.

IPC Classes  ?

• G01J 4/04 - Polarimeters using electric detection means
• G01J 4/02 - Polarimeters of separated-field typePolarimeters of half-shadow type
• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• G02B 5/30 - Polarising elements
• G02F 1/1333 - Constructional arrangements
• F21V 9/14 - Elements for modifying spectral properties, polarisation or intensity of the light emitted, e.g. filters for producing polarised light
• G02B 1/08 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of polarising materials
• G02B 5/20 - Filters
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour

Abstract

The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) one or more of the following kinases: DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, CLK1, CLK2, CLK3, CLK4, CDK7, CDK8/19, PI3K, PDGFrA/B, mTOR, HIPKs, and/or CMGC kinases leading to inhibition of WNT signaling. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds one or more of the following kinases: DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, CLK1, CLK2, CLK3, CLK4, CDK7, CDK8/19, PI3K, PDGFrA/B, mTOR, HIPKs, and/or CMGC kinases leading to inhibition of WNT signaling, such that the one or more kinases is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of the one or more kinases. The bifunctional compounds serve as therapeutics for the treatment of Alzheimer's disease, down syndrome, diabetes, an autoimmune disease, an inflammatory disorder (e.g., airway inflammation, osteoarthritis (e.g., knee related osteoarthritis)), cancer (e.g., glioblastoma, prostate cancer, metastatic breast cancer, metastatic lung cancer, multiple myeloma, secondary metastatic tumors of the brain, colorectal cancer, acute myeloid leukemia, myelodysplastic syndrome), a viral infection (e.g., SARS-CoV-2 infection (e.g., COVID-19)), and other diseases.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 35/00 - Antineoplastic agents
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 471/04 - Ortho-condensed systems

Abstract

A spectral characteristic of operation of a laser source containing, within its V-cavity, a gain medium structured to include a stack of substantially spatially-periodically distributed semiconductor material, is being tuned or varied by reshaping the V-cavity due to repositioning/reorienting the outermost reflectors limiting such cavity. When laser source configured as a VECSEL includes multiple pairs of the outermost reflectors (each pair defining a corresponding constituent V-cavity having the corresponding optical resonance), these multiple V-cavities are coupled at least through the carrier distributions within the common gain medium that such cavities share. Different modes of operation of such laser source.

IPC Classes  ?

• H01S 5/183 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only vertical cavities, e.g. vertical cavity surface-emitting lasers [VCSEL]
• H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
• H01S 5/065 - Mode lockingMode suppressionMode selection
• H01S 5/22 - Structure or shape of the semiconductor body to guide the optical wave having a ridge or a stripe structure

Abstract

The invention relates to cylindrical tunable fluidic lenses. The cylindrical optical power of the lenses may be continuously tuned within at least ±10 diopters, without inducing any significant spherical aberration, or any other significant aberrations. The lenses feature a geometry that produces minimal or no spherical defocus. These cylindrical tunable fluidic lenses could be used to induce and/or correct cylindrical optical aberrations in adaptive optical systems, particularly in ophthalmologic applications related to objective and automatic assessment of the refractive error of the eye, without the need of receiving feedback from the subjects.

IPC Classes  ?

• G02B 3/14 - Fluid-filled or evacuated lenses of variable focal length
• A61B 3/028 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing visual acuitySubjective types, i.e. testing apparatus requiring the active assistance of the patient for determination of refraction, e.g. phoropters
• A61B 3/04 - Trial framesSets of lenses for use therewith
• G02B 3/00 - Simple or compound lenses
• G02B 3/06 - Simple or compound lenses with non-spherical faces with cylindrical or toric faces
• G02C 7/02 - LensesLens systems

Abstract

A method includes determining one or more surface reactions of C, O, and H containing molecules on transitional metal surfaces based on a surface reaction database; establishing a set of descriptors for each surface reaction in the one or more surface reactions based on a Bronsted-Evans-Polanyi relationship (BEP); and predicting, using a machine learning model, an activation energy of the one or more surface reactions based on set of descriptors.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• C01B 3/32 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air
• C01B 3/38 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts

Abstract

Methods, systems and devices for administering green light to subjects are described. The described techniques can be used for managing cognitive deficits or memory impairments, reducing the symptoms associated with posttraumatic stress disorder (PTSD), anxiety and neurodegenerative diseases and other conditions. One example method for managing or minimizing cognitive deficits or memory impairments includes administering, for a first time period and according to a pre-arranged schedule of administrations, light with one or more wavelengths in the range between approximately 515 nm and approximately 535 nm to a retina of a subject. The method further includes administrating the light, for a second time and subsequent periods according to the pre-arranged schedule of administrations to the retina of the subject. The first, the second and the subsequent time periods occur on separate days, and the pre-arranged schedule of administrations includes administrations that span over at least one week.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light

Abstract

Epilepsy is one of the most common neurological disorders. However, there are currently no drugs available to prevent and/or reduce the development of said disorder. Thus, compositions and methods described herein prevent and/or arrest the development of epilepsy. Specifically, angiotensin receptor blocker (ARB), such as candesartan, is described to treat epileptic patients and those at risk for developing epilepsy.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 25/08 - AntiepilepticsAnticonvulsants

Abstract

Objective lens configurations are described that can be used to implement dual-view microscopes with two fields of view (FOVs). An example dual-view microscope objective includes a rear lens group, a front lens group, and a waveguide positioned between the rear and front lens groups. The waveguide includes a reflective region that receives light from the front lens group and partially reflects the light in a lateral direction away from the rear lens group while allowing a portion of the received light to be transmitted through the waveguide toward the rear lens group. The front and rear lens groups allow viewing or imaging of a sample in a first viewing or imaging mode having a first FOV. The front lens group and the reflective region of the waveguide allow viewing or imaging of the sample in a second viewing or imaging mode having a larger FOV compared to the first FOV.

IPC Classes  ?

• G02B 21/22 - Stereoscopic arrangements
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements

Abstract

A system and method are provided for low probability of detection (LPD) covert radar/lidar detection. A transmitter transmits a broadband light that is in a solar-radiation spectrum, and the broadband light is modulated using a constant amplitude modulation scheme such as M-ary phase shift keying (PSK), which makes the transmitted signal difficult to distinguish the signal from the background radiation. The radar return light from a target is collected and the target is detected by a cross-correlation calculation between the received light and the modulation pattern used to encode the transmitted signal. Further, in a turbulent environment, adaptive optics can be used to improve the detection probability.

IPC Classes  ?

• G01S 17/86 - Combinations of lidar systems with systems other than lidar, radar or sonar, e.g. with direction finders
• G01S 17/88 - Lidar systems, specially adapted for specific applications
• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
• G01S 17/894 - 3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
• H04B 10/556 - Digital modulation, e.g. differential phase shift keying [DPSK] or frequency shift keying [FSK]
• G01S 17/32 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated
• G01S 17/66 - Tracking systems using electromagnetic waves other than radio waves
• G01S 17/87 - Combinations of systems using electromagnetic waves other than radio waves
• H04B 10/548 - Phase or frequency modulation

Abstract

Epilepsy is one of the most common neurological disorders. However, there are currently no drugs available to prevent and/or reduce the development of said disorder. Thus, compositions and methods described herein prevent and/or arrest the development of epilepsy. Specifically, angiotensin receptor blocker (ARB), such as candesartan, is described to treat epileptic patients and those at risk for developing epilepsy.

IPC Classes  ?

• A61K 31/4245 - Oxadiazoles
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 25/08 - AntiepilepticsAnticonvulsants

Abstract

A system and method are provided for low probability to intercept (LPI) free-space optical (FSO) communications. A transmitter transmits a broadband light (e.g., but not limited to a full width half maximum of 10 nm or more) that is in a solar-radiation spectrum, and the broadband light is modulated using a modulation scheme (e.g., binary phase shift keying). The modulated light encodes a data packet that includes a header and a codeword generated using an error correction code. After propagating through an FSO channel, the receiver collects the transmitted modulated light and used one or more balanced detectors heterodyne detectors at different center wavelengths to convert the received light to respective RF signals, which are then processed to recover the information data encoded in the codeword.

IPC Classes  ?

• H04B 10/11 - Arrangements specific to free-space transmission, i.e. transmission through air or vacuum
• H03M 13/03 - Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words

Abstract

Provided herein are specially-configured apparatus for maximizing mechanical or acoustic transmission so that a biological material supported by the apparatus reliably experiences a mechanical or acoustic wave that has minimally degraded. In this manner, a biomarker may be reliably monitored and the effect of the mechanical or acoustic wave on the biological material determined. The platform is used to manipulate a cellular interaction with the mechanical or acoustic wave. Related methods of using and making are provided.

IPC Classes  ?

• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A portable air-quality-monitoring apparatus configured to detect and measure micron- and sub-micron-sized particles (down to 100 nm in dimension) in real time. The apparatus includes a film of fluid deposited onto the coverslip that is used to collect particles before the apparatus is deployed at outdoor monitoring sites, and can be used both in the environment devoid of a conventional optical lens element and in the environment employing such optical lens element. The presence of the film increases the scattering cross-section of particles smaller than the pixel size, thereby enabling the sub-pixel and sub-diffraction-limit sized particles to be detected.

IPC Classes  ?

• G01N 15/06 - Investigating concentration of particle suspensions
• G01N 21/53 - Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
• G01N 21/94 - Investigating contamination, e.g. dust

Goods & Services

Headwear; Clothing, namely, tops and bottoms; Clothing, namely, sweatshirts, shirts and shorts

Abstract

High mobility group box protein 1 (HMGB1) is a nuclear protein released during cell damage and stimulates inflammatory and proliferative pathways in the surviving neighboring cells. HMGB1 contains three cysteine residues (e.g., 23/45/106) involved in the extracellular HMGB1 oligomerization and receptor binding. The peptide compositions described herein shield the aforementioned cysteine residues, which block HMGB1 from binding to DNA and, thus, reduce apoptotic signaling within a cell. Furthermore, methods of treating inflammatory disease (e.g., PAH) by administering said peptide composition are described herein.

IPC Classes  ?

• C08K 7/08 - Oxygen-containing compounds
• A61K 38/10 - Peptides having 12 to 20 amino acids

Abstract

maxmaxmaxmaxmax, and display one or more subsequent waveforms compared to the target training pressure.

IPC Classes  ?

• A63B 23/18 - Exercising apparatus specially adapted for particular parts of the body for improving respiratory function
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/091 - Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/22 - ErgometryMeasuring muscular strength or the force of a muscular blow

Abstract

The present invention relates to compositions and methods for preventing and/or treating bacterial disease (e.g., disease caused by Neisseria sp. such as gonorrhea). In particular, the present invention provides vaccine compositions and agents targeting Neisseria host interaction genes.

IPC Classes  ?

• A61K 39/095 - Neisseria
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/04 - Antibacterial agents
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A method of treating fibrosis and cancer comprising targeting circulating cells is described herein. These circulating cells may be mechanoresponsive immune cells or circulating mesenchymal cells.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 35/00 - Antineoplastic agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Devices and electrochemical and spectroelectrochemical methods of characterizing a perovskite layer of a semiconductor device are described. One example method includes contacting the perovskite layer with a first surface of an electrolyte layer, where a second surface of the electrolyte layer is in contact with a first counter electrode. The method further includes embedding a first reference electrode in the electrolyte layer, applying a voltage to the first reference electrode, measuring a current between the first reference electrode and the first counter electrode, and characterizing the perovskite layer based on the applied voltage and the measured current between the first reference electrode the first counter electrode. Characterizing the perovskite layer includes characterizing cation defect states of the perovskite layer.

IPC Classes  ?

• G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• H01L 21/67 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
• G01N 27/406 - Cells and probes with solid electrolytes

Abstract

An occlusion-capable viewing device includes an imaging lens, a collimating lens, and a virtual display module, and between the imaging lens and the collimating lens, an image inverter, and a spatial light modulator. The imaging lens projects a first inverted image of a scene on to an entrance surface of the image inverter. The image inverter rotates the first inverted image to yield a first upright image. The spatial light modulator attenuates a first image-region of the first upright image to produce a modulated optical beam. The virtual display module includes a display device and a light combiner, which combines (i) the collimated optical beam and (ii) illumination emitted by the display device to yield an occluded image.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02B 27/30 - Collimators

Abstract

Methods and devices are described that rely on interference filter designs to provide a precise and granular spectral behavior by allowing emissions of circadian-active blue and green light to reach a viewer. An example wearable device includes one or more windows positioned to allow light from a light source to propagate toward a position of a wearer's eyes, and a spectral filter that includes a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to allow circadian-active spectra to reach the wearer's eyes while blocking spectral content other than the circadian-active spectra. The designed transmission and blocking characteristics include a contiguous transmission region and two contiguous blocking regions.

IPC Classes  ?

• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses

Abstract

Provided are devices that simulate in vivo conditions of a biological system and that are modular for reliable assembly and disassembly to improve handling of biological systems and subsequent analysis and experimentation therein. A center block having a fluidic network to support a biological material is in fluidic connection with a pair of side channels. With this platform, biological material may be supported and exposed to a plurality of well-defined fluidic characteristics and compositions.

IPC Classes  ?

• B67D 7/08 - Arrangements of devices for controlling, indicating, metering or registering quantity or price of liquid transferred
• C12M 3/04 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers

Abstract

A temperature-corrected biochemical sensor includes an optical resonator disposed proximate a single-mode optical fiber, the optical resonator being optically coupled to the optical fiber to receive optical whispering-gallery output light; a sensor detection system arranged to receive and detect the optical whispering-gallery output light to provide sensor signals; a temperature-correcting optical system to provide a reference beam of light to be combined at least partially coherently with a return light from the resonator to provide an interference light and convert, the interference light to temperature-correction signals; a data storage device comprising temperature calibration data for at least the optical fiber and the optical resonator; and a data processing system to calculate at least one physical property of a particle in contact with the optical resonator using the sensor signals such that the calculated physical property is temperature corrected using the temperature calibration data and the temperature-correction signals.

IPC Classes  ?

• G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator

Abstract

Provided herein are educational models that include a substrate and one or more 3D printed structures mounted or affixed thereon, where the one or more 3D printed structures resemble crystals, normal and/or abnormal cells, or casts found in a biofluid. Also provided herein are educational models that include one or more 3D printed structures contained (for example, dispersed or suspended) in a carrier, where the one or more 3D printed structures resemble crystals, normal and/or abnormal cells, or casts found in a biofluid. Also provided herein are kits having a plurality of educational models, where each of the educational model is individually identifiable, and an answer key or guide that provides an identification of each 3D printed structure contained in each of the plurality of individually identifiable educational models. The 3D printed structures can be dimensioned for viewing with the naked eye or can be dimensioned for viewing under magnification.

IPC Classes  ?

• G09B 23/26 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for molecular structuresModels for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for crystallography

Abstract

Methods and devices are described that relate to spectral filters and associated eyewear that are specifically designed to mitigate the disruptive effects of electric lighting on the circadian clock that can cause sleep deprivation and other physiological and psychological maladies. An example wearable device for viewing a real or virtual environment includes one or more windows positioned and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-rhythm-disruptive spectra from reaching the wearer's eyes while providing viewability of the real or virtual environment by allowing light outside of the circadian-rhythm-disruptive spectra to reach the wearer's eyes.

IPC Classes  ?

• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses
• G02B 5/28 - Interference filters

Abstract

The present invention provides a sustained drug release system comprising IL-2 and anti-IL-2 incorporated into a thermosensitive hydrogel that is engineered to be in liquid form at low temperatures for delivery, but form a hydrogel at physiological body temperatures to act as a sustained release platform. The thermostable hydrogel solution slowly releases IL-2 and anti-IL-2 to provide optimal concentrations for effective treatment of autoimmune diseases.

IPC Classes  ?

• A61K 9/06 - OintmentsBases therefor
• A61K 38/20 - Interleukins
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons

Abstract

Disclosed is a heart rate monitoring system containing a machine learning platform containing self-learning and/or personalizable algorithms capable of detecting and filtering out artifacts in signals indicative of an individual's heart rate, such signals generated from one or more electrocardiogram sensors. The self-learning and/or personalizable algorithms are updated periodically. Accordingly, the machine learning platform improves its accuracy in detecting and/or rejecting/filtering out artifacts and/or becomes more personalized as further signals indicative of an individual's heart rate are processed. The machine learning platform performs detection and filtering out of artifacts via dimension reduction algorithms. The system further contains a first algorithm for real time measurement of heart rate variability (HRV). Also disclosed is a heart rate monitoring method that implements a heart rate monitoring system disclosed herein. The heart rate monitoring system and method can partition physiological components of HRV from other non-physiological components, particularly physical activity and/or breathing.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/024 - Measuring pulse rate or heart rate

Abstract

Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61M 16/01 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes specially adapted for anaesthetising
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

An MRI protocol employing a new flyback echo-planar imaging (EPI) pulse sequence configured to acquire flyback EPI data in which chemical-shift artifact and magnetic field inhomogeneity are inherently encoded and a novel flyback EPI reconstructive image transformation procedure resulting in generating EPI images(s) that are not only substantially free from the Nyquist artifact of the MRI process but also substantially free from the chemical-shift artifact and geometric distortion of the MRI process.

IPC Classes  ?

• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/485 - NMR imaging systems with selection of signal or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information
• G01R 33/50 - NMR imaging systems based on the determination of relaxation times

Abstract

Polymeric venous valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. Methods of making and using such polymeric venous valve systems are also described. The polymeric venous valve systems are well-suited for use in low pressure and low shear venous environments.

IPC Classes  ?

• A61F 2/24 - Heart valves
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

Addition of a light-recombiner in the form of a diffraction grating to an advanced-volume-hologram filter system (conventionally containing only a pre-disperser diffraction grating and a volume holographic filter VHF configured as a volume Bragg grating, VBG) demonstrated recollimation and spatial overlap of light components at different wavelengths in addition to the spectral bandwidth optimization and signal-to-noise improvement. Here, the wide spectral bandwidth is ensured by the angular Bragg-matching of the pre-disperser with the VBG. The signal-to-noise improvement is obtained by the wavefront selectivity of the VBG. The cancellation of the spectral dispersion is achieved by the light-recombiner. Utilization of a light-recombiner in the form of a diffraction grating as opposed to another dispersive optic such as an optical prism additionally eliminates the potential for spatial chirp that normally reduces the usability of the conventional AVHF system in optical imaging applications.

IPC Classes  ?

• G03H 1/26 - Processes or apparatus specially adapted to produce multiple holograms or to obtain images from them, e.g. multicolour technique

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperdinyl-formamide (or similar) structure which function as adrenoreceptor antagonists, and their use as therapeutics for the treatment and/or prevention of pain and related conditions. In addition, the present invention provides compositions comprising a mixture of opioid receptor agonist compounds and such adrenoreceptor antagonists for the treatment and/or prevention of pain and related conditions.

IPC Classes  ?

• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
• A61K 31/4525 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine

Abstract

Nonsense-mediated mRNA decay, a cellular mechanism that eliminates mRNAs containing premature termination codons, underlies the loss of mutant protein caused by two independent disease-causing mutations (e.g., cardiomyopathy) in LMOD2. To counteract this, steric-blocking oligonucleotides (SBOs) were developed to obstruct the deposition of the exon junction complex, thereby preventing nonsense-mediated mRNA decay of the mutant LMOD2 transcripts and restoring mutant protein expression. This approach forms the basis for methods of treating subjects suffering from cardiomyopathy using these SBOs.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights. By plotting a topographical representation of the diffraction efficiencies resulting from such a surface profile, step heights may be optimized to direct a desired level of light power into the diffraction orders corresponding to near, intermediate, and distance vision, thereby optimizing the lens performance.

IPC Classes  ?

• G02C 7/04 - Contact lenses for the eyes
• A61F 2/14 - Eye parts, e.g. lenses or corneal implantsArtificial eyes
• A61F 2/16 - Intraocular lenses
• G02B 5/18 - Diffracting gratings
• G02C 7/02 - LensesLens systems
• G02C 7/06 - LensesLens systems bifocalLensesLens systems multifocal

Abstract

The present disclosure relates to compounds, compositions, and methods for inhibiting Nox4 signaling. Also described are methods of treating fibrotic disorders (e.g., pulmonary fibrosis, heart fibrosis, kidney fibrosis, liver fibrosis, skin fibrosis, mediastinal fibrosis, retroperitoneal cavity fibrosis, bone marrow fibrosis, scleroderma or systemic sclerosis) and acute respiratory distress syndrome (ARDS) using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/33 - Heterocyclic compounds

Abstract

Endometrial cancer (EC) is the most common gynecologic cancer in developed countries and the fourth most common cancer affecting women in the US. In contrast to other cancers, rates of EC continue to rise, and there are indications that social determinants of health and race and/or ethnicity contribute to risk. Thus, the methods described herein provide a non-invasive means of measuring protein biomarkers in the local cervicovaginal microenvironment. These novel biomarkers may be used for diagnosing and/or predicting women that are “at risk” for the development and progression of endometrial cancer (EC; e.g., EC type 1). Specifically, the methods herein may include obtaining a sample (e.g., CVL, vaginal swabs, or secretions) from a patient and producing a profile of at least five or more protein biomarkers from the collected sample.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Systems and methods for determining information representing an amount of an indicator of a soil trait based on a machine learning engine, and systems and methods for training the machine learning engine are described. An example method includes obtaining values of a plurality of environmental factors relating to a location, and determining the information representing the amount of the indicator by inputting the values of the plurality of environmental factors into a machine learning engine. The machine learning engine is trained using sample datasets each of which includes values of at least a portion of the plurality of environmental factors of a sample site and information representing an amount of the indicator of the sample site.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/24 - Earth materials

Abstract

Methods and systems for differentiating different phases of ice-to-water and water-to-ice transitions based on polarimetric values are described. One example method for discriminating ice from melting ice includes obtaining measured polarimetric values for a sample. The measured values are wavelength-resolved such that each of the measured values corresponds to a particular wavelength, or a particular range of wavelengths, in a long-wave infrared (LWIR) region, and the measured polarimetric values span a plurality of wavelengths, or ranges of wavelengths, within the LWIR region. The method further includes determining a plurality of wavelength-resolved degree of polarization (DoP) values based on the measured polarimetric values, comparing the plurality of wavelength-resolved DoP values to a reference set of DoP values, and distinguishing ice from melting ice based on the comparison to the reference set of DoP values.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties
• G01N 21/3554 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for determining moisture content
• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
• G01N 33/18 - Water
• G01J 4/04 - Polarimeters using electric detection means

Abstract

Solar balloons are a simple and lightweight option for aerial exploration and meteorological data collection both terrestrially and on other planets. By using lightweight materials that absorb visual light and emit low levels of thermal radiation, solar balloons behave similarly to hot air balloons but can ascend to much higher altitudes. Unlike hot air balloons, which use an onboard heat source to raise the temperature of the internal air, solar balloons generate heat by absorbing solar radiation, providing a free source of lift and eliminating the need for carrying an extra tank of lighter-than-air gas or fuel. The solar balloons of the present invention include mechanical vents on the tops of the balloons to store and release hot air. Using these mechanical vents, the balloons can adjust altitude to enter regions of the atmosphere with different wind flows, which can lead to horizontal controllability of the platform.

IPC Classes  ?

• B64B 1/44 - Balloons adapted to maintain predetermined altitude
• B64B 1/64 - Gas-valve operating mechanisms

Abstract

Methods for manipulating metabolism in astrocytes to improve astrocytic and neuronal function, as well as individual pathology hallmarks and symptoms during the development of neurodegeneration by increasing PPARa expression and activity specifically in astrocytes within the central nervous system to treat a variety of neurodegenerative conditions including but not limited to conditions involving neuronal lipid dysregulation, oxidative damage, accumulation of β-amyloid or other protein aggregates, dementia, and motor dysfunction.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C12N 15/86 - Viral vectors
• C12N 15/864 - Parvoviral vectors

Abstract

Examples systems including an apparatus for hydrogen production are disclosed, defining two or more reaction chambers for generating a redox reaction using a redox material. The reaction chambers are rotatable relative to a thermal or heat source for reciprocal reduction and oxidation reactions of each chamber. This differentiates the temperatures of each chamber to house different stages of thermochemical reactions for hydrogen production

IPC Classes  ?

• C01B 3/06 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 60/20 - Arrangements for storing heat collected by solar heat collectors using chemical reactions, e.g. thermochemical reactions or isomerisation reactions

Abstract

Disclosed herein is a fusion peptide comprising an inactive peptide fragment of Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and a cell internalization sequence, wherein the SGK1 fragment is capable of binding and sequestering glucocorticoid-induced leucine zipper (GILZ). In some embodiments, the inactive peptide fragment of SGK1 binds and sequesters GILZ, preventing it from binding and extending the half-life of endogenous SGK1. Also disclosed herein is a method for treating a disease associated with aberrant Serum/Glucocorticoid Regulated Kinase 1 (SGK1) activity in a subject that involves administering to the subject an agent that blocks the binding of endogenous SGK1 to endogenous glucocorticoid-induced leucine zipper (GILZ).

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

An electrospray needle comprising a coating inside the needle, wherein the coating is a non-conductive and non-ionizable organic material, and in some embodiments comprising a conductive outer coating; methods of making the electrospray needle, systems that use the electrospray needle, methods of detection using the electrospray needle, and a kit that includes the electrospray needle.

IPC Classes  ?

• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• C03C 17/00 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating
• C03C 17/06 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with metals
• C03C 17/30 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with organic material with silicon-containing compounds
• G01N 30/72 - Mass spectrometers

Abstract

An imaging probe includes a housing, an illumination fiber, a camera, a band-stop filter, and a sample collector. The housing has a distal tip. The illumination fiber spans between the distal tip and a proximal end of the housing, and terminates at the distal tip, such that light carried by the illumination fiber illuminates a target in front of the distal tip. The camera captures an image in a field of view that overlaps a field of illumination of the illumination fiber. The band-stop filter is between the distal tip and the camera. The sample collector collects a sample from the target. And each of the illumination fiber, the camera, the band-stop filter, and the sample collector is at least partially inside the housing.

IPC Classes  ?

• A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 10/02 - Instruments for taking cell samples or for biopsy

Abstract

5050 value down to about 0.4 nM). The potency of the disclosed PLpro inhibitors outperforms previously reported PLpro inhibitors, such as GRL0617, and non-covalent PLpro inhibitors. Pharmaceutical compositions containing the PLpro inhibitors are also described. Methods of using the PLpro inhibitors or the pharmaceutical compositions for preventing or treating diseases and/or disorders caused by a coronavirus are also described.

IPC Classes  ?

• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
• A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/14 - Antivirals for RNA viruses

Abstract

All-reflective objective lens devices and methods designing such devices are described. The objective lens configurations include one or more freeform surfaces that and have high numerical apertures. An example all-reflective objective lens configuration includes at least four mirrors, where each mirror has a freeform surface, and is positioned to allow light from an object to enter objective lens configuration and reflect from each of the at least four mirrors only once before reaching a location of an aperture stop identifying an exit location objective lens configuration. The mirrors are positioned within the objective lens configuration to provide an unobscured field of view, a local optical axis of each of the mirrors is not colinear with a global optical axis of the all-reflective objective lens configuration, and the aperture stop is not positioned internal to the all-reflective objective lens configuration.

IPC Classes  ?

• G02B 17/06 - Catoptric systems, e.g. image erecting and reversing system using mirrors only
• G02B 21/04 - Objectives involving mirrors
• G02B 17/02 - Catoptric systems, e.g. image erecting and reversing system

Abstract

The present invention is directed to polymers comprising glycolipids and methods for producing and using the same. In particular, the polymers of the invention comprise a polymer backbone and a plurality of glycolipid side chains. The glycolipid moieties present in polymers of the invention are metal ion complexing agents. As such, polymers described herein can be used for the remediation of aqueous solutions to remove metal ions.

IPC Classes  ?

• C08J 3/075 - Macromolecular gels
• C02F 1/56 - Macromolecular compounds
• C02F 101/20 - Heavy metals or heavy metal compounds
• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a 6,5-heterocyclic structure (e.g., compounds having a imidazopyridine, imidazopyrimidine, imidazopyrazine, imidazopyridazine, imidazotriazine, benzoimidazole, benzotriazole, benzoisoxazole, purine, indazole, triazolotriazine, triazolopyridazine, triazolopyrimidine, triazolopyrazine, triazolotetrazine, triazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolopyridazine, pyrazolotriazine, pyrazolopyridine, isoxazolopyrazine, isoxazolopyrimidine, isoxazolopyrdiazine, isoxazolotriazine, or isoxalopyridine structure) which function as inhibitors of DYRK1A, DYRK1B, and Clk-1, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, diabetes, glioblastoma, autoimmune diseases, cancer (e.g., glioblastoma, prostate cancer), inflammatory disorders (e.g., airway inflammation), and other diseases.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 487/04 - Ortho-condensed systems
• C07D 498/08 - Bridged systems

Abstract

Dust poses a significant threat to human and environmental health. In 2015, an estimated 4.2 million deaths, as well as numerous health issues, were attributed to dust. Unlike other major contaminant transport pathways (e.g., water, soil, biota), atmospheric transmission is relatively unobstructed, able to rapidly transport large masses of materials over long distances and broadly impact areas downwind on local to global scales. Accordingly, dust affects global biogeochemical cycles, pollutes water bodies and air masses, and impacts global climate. Therefore, developing innovative, environmentally-compatible technologies capable of mitigating dust emissions is crucial to protect human and environmental health from mining related dust. The present invention features a method for suppressing dust from a substrate surface, said method comprising applying an effective amount of dust suppressant composition to said substrate surface, wherein said dust suppressant composition comprises an aqueous solution of a glycolipid.

IPC Classes  ?

• C09K 3/22 - Materials not provided for elsewhere for dust-laying or dust-absorbing
• E21F 5/06 - Fluids used for spraying

Abstract

A system that uses a rule-based parser and/or one or more machine learning models—e.g., a bidirectional gated recurrent unit (BiGRU) model, a hybrid bidirectional long short-term memory (BiLSTM-H) model, and/or a multilabel BiLSTM (BiLSTM-M) model, a large language model (LLM)—to label natural language sentences as indicative of diagnostic criteria used to diagnose and/or assess the severity of a mental disorder or other medical condition. In some embodiments, the system also determines whether the identified diagnostic criteria are indicative of a disorder under established medical guidelines and provides a final diagnostic label. By outputting both a diagnosis consistent with established medical guidelines and an understanding of the identified diagnostic criteria used to make that diagnosis, the disclosed system provides more clinical value to practitioners than the existing “black box” models used for medical diagnoses.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

An educational application that leverages gold standard data—several thousand examples of natural language sentences, extracted from electronic health records and provided by laypersons in response to surveys, describing behaviors in children indicative of autism spectrum disorder—to enable practitioners to recognize the language used by clinicians and laypersons to describe behavior indicative of autism spectrum disorder. The application provides positive examples of behaviors labeled as being indicative of one of the diagnostic criteria used to diagnose autism as well as negative examples (e.g., randomly selected from electronic health records) that are not indicative of autism spectrum disorder. Accordingly, the disclosed educational application teaches users to distinguish between relevant and non-relevant behaviors (e.g., a positive example versus a negative example), learn the accurate diagnostic criterion label (e.g., an A1 diagnostic criterion versus an A2 diagnostic criterion), and/or diagnose a case based on the combination of labels present or missing.

IPC Classes  ?

• G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

Methods for enhancing the therapeutic effects of phenols comprising the oral coadministration or sequential oral administration of a phenol and glucuronidase, and compositions for enhancing the therapeutic effects of phenols.

IPC Classes  ?

• A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• A61K 31/12 - Ketones
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)

Abstract

Surface-engineered immune cells, such as natural killer cells, grafted with targeting moiety-drug complexes. The present invention combines chemotherapy and immunotherapy by engineering the immune cells to target specific tumor cells through antigen recognition and deliver potent chemotherapeutic agents, thereby destroying the tumor cells. The surface-engineered immune cells may be prepared using a one-step method. The present invention also provides kits for preparing the surface-engineered immune cells.

IPC Classes  ?

• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 35/00 - Antineoplastic agents

Abstract

Dividers for small vertebrate animal cages are provided. In one aspect, a small vertebrate animal cage including a floor and a plurality of walls forming a housing area and a divider dividing the housing area into a common milieu area and two or more segregated individual nesting areas. The divider includes two or more dividing walls connected together to form an angle therebetween.

IPC Classes  ?

• A01K 1/00 - Housing animalsEquipment therefor
• A01K 1/03 - Housing for domestic or laboratory animals
• A01K 1/02 - PigstiesDog-kennelsRabbit-hutches or the like

Abstract

This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions comprising one or more of agents capable of protecting neurons from cell death and unregulated microglia phagocytic activity.

IPC Classes  ?

• A61K 31/26 - Cyanate or isocyanate estersThiocyanate or isothiocyanate esters
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Provided herein are compositions and methods for characterizing and treating cancer. In particular, provided herein are compositions and methods for identifying subjects with breast cancer with increased likelihood of bone metastasis and providing treatment to prevent such metastases.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer