Abstract

High mobility group box protein 1 (HMGB1) is a nuclear protein released during cell damage and stimulates inflammatory and proliferative pathways in the surviving neighboring cells. HMGB1 contains three cysteine residues (e.g., 23/45/106) involved in the extracellular HMGB1 oligomerization and receptor binding. The peptide compositions described herein shield the aforementioned cysteine residues, which block HMGB1 from binding to DNA and, thus, reduce apoptotic signaling within a cell. Furthermore, methods of treating inflammatory disease (e.g., PAH) by administering said peptide composition are described herein.

IPC Classes  ?

• C08K 7/08 - Oxygen-containing compounds
• A61K 38/10 - Peptides having 12 to 20 amino acids

Abstract

maxmaxmaxmaxmax, and display one or more subsequent waveforms compared to the target training pressure.

IPC Classes  ?

• A63B 23/18 - Exercising apparatus specially adapted for particular parts of the body for improving respiratory function
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/091 - Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
• A61B 5/22 - ErgometryMeasuring muscular strength or the force of a muscular blow

Abstract

The present invention relates to compositions and methods for preventing and/or treating bacterial disease (e.g., disease caused by Neisseria sp. such as gonorrhea). In particular, the present invention provides vaccine compositions and agents targeting Neisseria host interaction genes.

IPC Classes  ?

• A61K 39/095 - Neisseria
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/04 - Antibacterial agents
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Devices and electrochemical and spectroelectrochemical methods of characterizing a perovskite layer of a semiconductor device are described. One example method includes contacting the perovskite layer with a first surface of an electrolyte layer, where a second surface of the electrolyte layer is in contact with a first counter electrode. The method further includes embedding a first reference electrode in the electrolyte layer, applying a voltage to the first reference electrode, measuring a current between the first reference electrode and the first counter electrode, and characterizing the perovskite layer based on the applied voltage and the measured current between the first reference electrode the first counter electrode. Characterizing the perovskite layer includes characterizing cation defect states of the perovskite layer.

IPC Classes  ?

• G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• H01L 21/67 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
• G01N 27/406 - Cells and probes with solid electrolytes

Abstract

A method of treating fibrosis and cancer comprising targeting circulating cells is described herein. These circulating cells may be mechanoresponsive immune cells or circulating mesenchymal cells.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 35/00 - Antineoplastic agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Methods and devices are described that rely on interference filter designs to provide a precise and granular spectral behavior by allowing emissions of circadian-active blue and green light to reach a viewer. An example wearable device includes one or more windows positioned to allow light from a light source to propagate toward a position of a wearer's eyes, and a spectral filter that includes a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to allow circadian-active spectra to reach the wearer's eyes while blocking spectral content other than the circadian-active spectra. The designed transmission and blocking characteristics include a contiguous transmission region and two contiguous blocking regions.

IPC Classes  ?

• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses

Abstract

An occlusion-capable viewing device includes an imaging lens, a collimating lens, and a virtual display module, and between the imaging lens and the collimating lens, an image inverter, and a spatial light modulator. The imaging lens projects a first inverted image of a scene on to an entrance surface of the image inverter. The image inverter rotates the first inverted image to yield a first upright image. The spatial light modulator attenuates a first image-region of the first upright image to produce a modulated optical beam. The virtual display module includes a display device and a light combiner, which combines (i) the collimated optical beam and (ii) illumination emitted by the display device to yield an occluded image.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02B 27/30 - Collimators

Abstract

Provided are devices that simulate in vivo conditions of a biological system and that are modular for reliable assembly and disassembly to improve handling of biological systems and subsequent analysis and experimentation therein. A center block having a fluidic network to support a biological material is in fluidic connection with a pair of side channels. With this platform, biological material may be supported and exposed to a plurality of well-defined fluidic characteristics and compositions.

IPC Classes  ?

• B67D 7/08 - Arrangements of devices for controlling, indicating, metering or registering quantity or price of liquid transferred
• C12M 3/04 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers

Abstract

A temperature-corrected biochemical sensor includes an optical resonator disposed proximate a single-mode optical fiber, the optical resonator being optically coupled to the optical fiber to receive optical whispering-gallery output light; a sensor detection system arranged to receive and detect the optical whispering-gallery output light to provide sensor signals; a temperature-correcting optical system to provide a reference beam of light to be combined at least partially coherently with a return light from the resonator to provide an interference light and convert, the interference light to temperature-correction signals; a data storage device comprising temperature calibration data for at least the optical fiber and the optical resonator; and a data processing system to calculate at least one physical property of a particle in contact with the optical resonator using the sensor signals such that the calculated physical property is temperature corrected using the temperature calibration data and the temperature-correction signals.

IPC Classes  ?

• G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator

Abstract

Provided herein are educational models that include a substrate and one or more 3D printed structures mounted or affixed thereon, where the one or more 3D printed structures resemble crystals, normal and/or abnormal cells, or casts found in a biofluid. Also provided herein are educational models that include one or more 3D printed structures contained (for example, dispersed or suspended) in a carrier, where the one or more 3D printed structures resemble crystals, normal and/or abnormal cells, or casts found in a biofluid. Also provided herein are kits having a plurality of educational models, where each of the educational model is individually identifiable, and an answer key or guide that provides an identification of each 3D printed structure contained in each of the plurality of individually identifiable educational models. The 3D printed structures can be dimensioned for viewing with the naked eye or can be dimensioned for viewing under magnification.

IPC Classes  ?

• G09B 23/26 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for molecular structuresModels for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for crystallography

Abstract

Methods and devices are described that relate to spectral filters and associated eyewear that are specifically designed to mitigate the disruptive effects of electric lighting on the circadian clock that can cause sleep deprivation and other physiological and psychological maladies. An example wearable device for viewing a real or virtual environment includes one or more windows positioned and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-rhythm-disruptive spectra from reaching the wearer's eyes while providing viewability of the real or virtual environment by allowing light outside of the circadian-rhythm-disruptive spectra to reach the wearer's eyes.

IPC Classes  ?

• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses
• G02B 5/28 - Interference filters

Abstract

The present invention provides a sustained drug release system comprising IL-2 and anti-IL-2 incorporated into a thermosensitive hydrogel that is engineered to be in liquid form at low temperatures for delivery, but form a hydrogel at physiological body temperatures to act as a sustained release platform. The thermostable hydrogel solution slowly releases IL-2 and anti-IL-2 to provide optimal concentrations for effective treatment of autoimmune diseases.

IPC Classes  ?

• A61K 9/06 - OintmentsBases therefor
• A61K 38/20 - Interleukins
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons

Abstract

Disclosed is a heart rate monitoring system containing a machine learning platform containing self-learning and/or personalizable algorithms capable of detecting and filtering out artifacts in signals indicative of an individual's heart rate, such signals generated from one or more electrocardiogram sensors. The self-learning and/or personalizable algorithms are updated periodically. Accordingly, the machine learning platform improves its accuracy in detecting and/or rejecting/filtering out artifacts and/or becomes more personalized as further signals indicative of an individual's heart rate are processed. The machine learning platform performs detection and filtering out of artifacts via dimension reduction algorithms. The system further contains a first algorithm for real time measurement of heart rate variability (HRV). Also disclosed is a heart rate monitoring method that implements a heart rate monitoring system disclosed herein. The heart rate monitoring system and method can partition physiological components of HRV from other non-physiological components, particularly physical activity and/or breathing.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/024 - Measuring pulse rate or heart rate

Abstract

Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61M 16/01 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes specially adapted for anaesthetising
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

An MRI protocol employing a new flyback echo-planar imaging (EPI) pulse sequence configured to acquire flyback EPI data in which chemical-shift artifact and magnetic field inhomogeneity are inherently encoded and a novel flyback EPI reconstructive image transformation procedure resulting in generating EPI images(s) that are not only substantially free from the Nyquist artifact of the MRI process but also substantially free from the chemical-shift artifact and geometric distortion of the MRI process.

IPC Classes  ?

• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/485 - NMR imaging systems with selection of signal or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information
• G01R 33/50 - NMR imaging systems based on the determination of relaxation times

Abstract

Polymeric venous valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. Methods of making and using such polymeric venous valve systems are also described. The polymeric venous valve systems are well-suited for use in low pressure and low shear venous environments.

IPC Classes  ?

• A61F 2/24 - Heart valves
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

Addition of a light-recombiner in the form of a diffraction grating to an advanced-volume-hologram filter system (conventionally containing only a pre-disperser diffraction grating and a volume holographic filter VHF configured as a volume Bragg grating, VBG) demonstrated recollimation and spatial overlap of light components at different wavelengths in addition to the spectral bandwidth optimization and signal-to-noise improvement. Here, the wide spectral bandwidth is ensured by the angular Bragg-matching of the pre-disperser with the VBG. The signal-to-noise improvement is obtained by the wavefront selectivity of the VBG. The cancellation of the spectral dispersion is achieved by the light-recombiner. Utilization of a light-recombiner in the form of a diffraction grating as opposed to another dispersive optic such as an optical prism additionally eliminates the potential for spatial chirp that normally reduces the usability of the conventional AVHF system in optical imaging applications.

IPC Classes  ?

• G03H 1/26 - Processes or apparatus specially adapted to produce multiple holograms or to obtain images from them, e.g. multicolour technique

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperdinyl-formamide (or similar) structure which function as adrenoreceptor antagonists, and their use as therapeutics for the treatment and/or prevention of pain and related conditions. In addition, the present invention provides compositions comprising a mixture of opioid receptor agonist compounds and such adrenoreceptor antagonists for the treatment and/or prevention of pain and related conditions.

IPC Classes  ?

• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
• A61K 31/4525 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine

Abstract

Nonsense-mediated mRNA decay, a cellular mechanism that eliminates mRNAs containing premature termination codons, underlies the loss of mutant protein caused by two independent disease-causing mutations (e.g., cardiomyopathy) in LMOD2. To counteract this, steric-blocking oligonucleotides (SBOs) were developed to obstruct the deposition of the exon junction complex, thereby preventing nonsense-mediated mRNA decay of the mutant LMOD2 transcripts and restoring mutant protein expression. This approach forms the basis for methods of treating subjects suffering from cardiomyopathy using these SBOs.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights. By plotting a topographical representation of the diffraction efficiencies resulting from such a surface profile, step heights may be optimized to direct a desired level of light power into the diffraction orders corresponding to near, intermediate, and distance vision, thereby optimizing the lens performance.

IPC Classes  ?

• G02C 7/04 - Contact lenses for the eyes
• A61F 2/14 - Eye parts, e.g. lenses or corneal implantsArtificial eyes
• A61F 2/16 - Intraocular lenses
• G02B 5/18 - Diffracting gratings
• G02C 7/02 - LensesLens systems

Abstract

The present disclosure relates to compounds, compositions, and methods for inhibiting Nox4 signaling. Also described are methods of treating fibrotic disorders (e.g., pulmonary fibrosis, heart fibrosis, kidney fibrosis, liver fibrosis, skin fibrosis, mediastinal fibrosis, retroperitoneal cavity fibrosis, bone marrow fibrosis, scleroderma or systemic sclerosis) and acute respiratory distress syndrome (ARDS) using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/33 - Heterocyclic compounds

Abstract

Endometrial cancer (EC) is the most common gynecologic cancer in developed countries and the fourth most common cancer affecting women in the US. In contrast to other cancers, rates of EC continue to rise, and there are indications that social determinants of health and race and/or ethnicity contribute to risk. Thus, the methods described herein provide a non-invasive means of measuring protein biomarkers in the local cervicovaginal microenvironment. These novel biomarkers may be used for diagnosing and/or predicting women that are “at risk” for the development and progression of endometrial cancer (EC; e.g., EC type 1). Specifically, the methods herein may include obtaining a sample (e.g., CVL, vaginal swabs, or secretions) from a patient and producing a profile of at least five or more protein biomarkers from the collected sample.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Systems and methods for determining information representing an amount of an indicator of a soil trait based on a machine learning engine, and systems and methods for training the machine learning engine are described. An example method includes obtaining values of a plurality of environmental factors relating to a location, and determining the information representing the amount of the indicator by inputting the values of the plurality of environmental factors into a machine learning engine. The machine learning engine is trained using sample datasets each of which includes values of at least a portion of the plurality of environmental factors of a sample site and information representing an amount of the indicator of the sample site.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/24 - Earth materials

Abstract

Methods and systems for differentiating different phases of ice-to-water and water-to-ice transitions based on polarimetric values are described. One example method for discriminating ice from melting ice includes obtaining measured polarimetric values for a sample. The measured values are wavelength-resolved such that each of the measured values corresponds to a particular wavelength, or a particular range of wavelengths, in a long-wave infrared (LWIR) region, and the measured polarimetric values span a plurality of wavelengths, or ranges of wavelengths, within the LWIR region. The method further includes determining a plurality of wavelength-resolved degree of polarization (DoP) values based on the measured polarimetric values, comparing the plurality of wavelength-resolved DoP values to a reference set of DoP values, and distinguishing ice from melting ice based on the comparison to the reference set of DoP values.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties
• G01N 21/3554 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for determining moisture content
• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
• G01N 33/18 - Water
• G01J 4/04 - Polarimeters using electric detection means

Abstract

Solar balloons are a simple and lightweight option for aerial exploration and meteorological data collection both terrestrially and on other planets. By using lightweight materials that absorb visual light and emit low levels of thermal radiation, solar balloons behave similarly to hot air balloons but can ascend to much higher altitudes. Unlike hot air balloons, which use an onboard heat source to raise the temperature of the internal air, solar balloons generate heat by absorbing solar radiation, providing a free source of lift and eliminating the need for carrying an extra tank of lighter-than-air gas or fuel. The solar balloons of the present invention include mechanical vents on the tops of the balloons to store and release hot air. Using these mechanical vents, the balloons can adjust altitude to enter regions of the atmosphere with different wind flows, which can lead to horizontal controllability of the platform.

IPC Classes  ?

• B64B 1/44 - Balloons adapted to maintain predetermined altitude
• B64B 1/64 - Gas-valve operating mechanisms

Abstract

Methods for manipulating metabolism in astrocytes to improve astrocytic and neuronal function, as well as individual pathology hallmarks and symptoms during the development of neurodegeneration by increasing PPARa expression and activity specifically in astrocytes within the central nervous system to treat a variety of neurodegenerative conditions including but not limited to conditions involving neuronal lipid dysregulation, oxidative damage, accumulation of β-amyloid or other protein aggregates, dementia, and motor dysfunction.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C12N 15/86 - Viral vectors
• C12N 15/864 - Parvoviral vectors

Abstract

Examples systems including an apparatus for hydrogen production are disclosed, defining two or more reaction chambers for generating a redox reaction using a redox material. The reaction chambers are rotatable relative to a thermal or heat source for reciprocal reduction and oxidation reactions of each chamber. This differentiates the temperatures of each chamber to house different stages of thermochemical reactions for hydrogen production

IPC Classes  ?

• C01B 3/06 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 60/20 - Arrangements for storing heat collected by solar heat collectors using chemical reactions, e.g. thermochemical reactions or isomerisation reactions

Abstract

Disclosed herein is a fusion peptide comprising an inactive peptide fragment of Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and a cell internalization sequence, wherein the SGK1 fragment is capable of binding and sequestering glucocorticoid-induced leucine zipper (GILZ). In some embodiments, the inactive peptide fragment of SGK1 binds and sequesters GILZ, preventing it from binding and extending the half-life of endogenous SGK1. Also disclosed herein is a method for treating a disease associated with aberrant Serum/Glucocorticoid Regulated Kinase 1 (SGK1) activity in a subject that involves administering to the subject an agent that blocks the binding of endogenous SGK1 to endogenous glucocorticoid-induced leucine zipper (GILZ).

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

An electrospray needle comprising a coating inside the needle, wherein the coating is a non-conductive and non-ionizable organic material, and in some embodiments comprising a conductive outer coating; methods of making the electrospray needle, systems that use the electrospray needle, methods of detection using the electrospray needle, and a kit that includes the electrospray needle.

IPC Classes  ?

• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• C03C 17/00 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating
• C03C 17/06 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with metals
• C03C 17/30 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with organic material with silicon-containing compounds
• G01N 30/72 - Mass spectrometers

Abstract

An imaging probe includes a housing, an illumination fiber, a camera, a band-stop filter, and a sample collector. The housing has a distal tip. The illumination fiber spans between the distal tip and a proximal end of the housing, and terminates at the distal tip, such that light carried by the illumination fiber illuminates a target in front of the distal tip. The camera captures an image in a field of view that overlaps a field of illumination of the illumination fiber. The band-stop filter is between the distal tip and the camera. The sample collector collects a sample from the target. And each of the illumination fiber, the camera, the band-stop filter, and the sample collector is at least partially inside the housing.

IPC Classes  ?

• A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 10/02 - Instruments for taking cell samples or for biopsy

Abstract

5050 value down to about 0.4 nM). The potency of the disclosed PLpro inhibitors outperforms previously reported PLpro inhibitors, such as GRL0617, and non-covalent PLpro inhibitors. Pharmaceutical compositions containing the PLpro inhibitors are also described. Methods of using the PLpro inhibitors or the pharmaceutical compositions for preventing or treating diseases and/or disorders caused by a coronavirus are also described.

IPC Classes  ?

• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
• A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/14 - Antivirals for RNA viruses

Abstract

All-reflective objective lens devices and methods designing such devices are described. The objective lens configurations include one or more freeform surfaces that and have high numerical apertures. An example all-reflective objective lens configuration includes at least four mirrors, where each mirror has a freeform surface, and is positioned to allow light from an object to enter objective lens configuration and reflect from each of the at least four mirrors only once before reaching a location of an aperture stop identifying an exit location objective lens configuration. The mirrors are positioned within the objective lens configuration to provide an unobscured field of view, a local optical axis of each of the mirrors is not colinear with a global optical axis of the all-reflective objective lens configuration, and the aperture stop is not positioned internal to the all-reflective objective lens configuration.

IPC Classes  ?

• G02B 17/06 - Catoptric systems, e.g. image erecting and reversing system using mirrors only
• G02B 21/04 - Objectives involving mirrors
• G02B 17/02 - Catoptric systems, e.g. image erecting and reversing system

Abstract

The present invention is directed to polymers comprising glycolipids and methods for producing and using the same. In particular, the polymers of the invention comprise a polymer backbone and a plurality of glycolipid side chains. The glycolipid moieties present in polymers of the invention are metal ion complexing agents. As such, polymers described herein can be used for the remediation of aqueous solutions to remove metal ions.

IPC Classes  ?

• C08J 3/075 - Macromolecular gels
• C02F 1/56 - Macromolecular compounds
• C02F 101/20 - Heavy metals or heavy metal compounds
• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a 6,5-heterocyclic structure (e.g., compounds having a imidazopyridine, imidazopyrimidine, imidazopyrazine, imidazopyridazine, imidazotriazine, benzoimidazole, benzotriazole, benzoisoxazole, purine, indazole, triazolotriazine, triazolopyridazine, triazolopyrimidine, triazolopyrazine, triazolotetrazine, triazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolopyridazine, pyrazolotriazine, pyrazolopyridine, isoxazolopyrazine, isoxazolopyrimidine, isoxazolopyrdiazine, isoxazolotriazine, or isoxalopyridine structure) which function as inhibitors of DYRK1A, DYRK1B, and Clk-1, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, diabetes, glioblastoma, autoimmune diseases, cancer (e.g., glioblastoma, prostate cancer), inflammatory disorders (e.g., airway inflammation), and other diseases.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 487/04 - Ortho-condensed systems
• C07D 498/08 - Bridged systems

Abstract

Dust poses a significant threat to human and environmental health. In 2015, an estimated 4.2 million deaths, as well as numerous health issues, were attributed to dust. Unlike other major contaminant transport pathways (e.g., water, soil, biota), atmospheric transmission is relatively unobstructed, able to rapidly transport large masses of materials over long distances and broadly impact areas downwind on local to global scales. Accordingly, dust affects global biogeochemical cycles, pollutes water bodies and air masses, and impacts global climate. Therefore, developing innovative, environmentally-compatible technologies capable of mitigating dust emissions is crucial to protect human and environmental health from mining related dust. The present invention features a method for suppressing dust from a substrate surface, said method comprising applying an effective amount of dust suppressant composition to said substrate surface, wherein said dust suppressant composition comprises an aqueous solution of a glycolipid.

IPC Classes  ?

• C09K 3/22 - Materials not provided for elsewhere for dust-laying or dust-absorbing
• E21F 5/06 - Fluids used for spraying

Abstract

A system that uses a rule-based parser and/or one or more machine learning models—e.g., a bidirectional gated recurrent unit (BiGRU) model, a hybrid bidirectional long short-term memory (BiLSTM-H) model, and/or a multilabel BiLSTM (BiLSTM-M) model, a large language model (LLM)—to label natural language sentences as indicative of diagnostic criteria used to diagnose and/or assess the severity of a mental disorder or other medical condition. In some embodiments, the system also determines whether the identified diagnostic criteria are indicative of a disorder under established medical guidelines and provides a final diagnostic label. By outputting both a diagnosis consistent with established medical guidelines and an understanding of the identified diagnostic criteria used to make that diagnosis, the disclosed system provides more clinical value to practitioners than the existing “black box” models used for medical diagnoses.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

An educational application that leverages gold standard data—several thousand examples of natural language sentences, extracted from electronic health records and provided by laypersons in response to surveys, describing behaviors in children indicative of autism spectrum disorder—to enable practitioners to recognize the language used by clinicians and laypersons to describe behavior indicative of autism spectrum disorder. The application provides positive examples of behaviors labeled as being indicative of one of the diagnostic criteria used to diagnose autism as well as negative examples (e.g., randomly selected from electronic health records) that are not indicative of autism spectrum disorder. Accordingly, the disclosed educational application teaches users to distinguish between relevant and non-relevant behaviors (e.g., a positive example versus a negative example), learn the accurate diagnostic criterion label (e.g., an A1 diagnostic criterion versus an A2 diagnostic criterion), and/or diagnose a case based on the combination of labels present or missing.

IPC Classes  ?

• G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

Methods for enhancing the therapeutic effects of phenols comprising the oral coadministration or sequential oral administration of a phenol and glucuronidase, and compositions for enhancing the therapeutic effects of phenols.

IPC Classes  ?

• A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• A61K 31/12 - Ketones
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)

Abstract

Surface-engineered immune cells, such as natural killer cells, grafted with targeting moiety-drug complexes. The present invention combines chemotherapy and immunotherapy by engineering the immune cells to target specific tumor cells through antigen recognition and deliver potent chemotherapeutic agents, thereby destroying the tumor cells. The surface-engineered immune cells may be prepared using a one-step method. The present invention also provides kits for preparing the surface-engineered immune cells.

IPC Classes  ?

• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 35/00 - Antineoplastic agents

Abstract

Dividers for small vertebrate animal cages are provided. In one aspect, a small vertebrate animal cage including a floor and a plurality of walls forming a housing area and a divider dividing the housing area into a common milieu area and two or more segregated individual nesting areas. The divider includes two or more dividing walls connected together to form an angle therebetween.

IPC Classes  ?

• A01K 1/00 - Housing animalsEquipment therefor

Abstract

This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions comprising one or more of agents capable of protecting neurons from cell death and unregulated microglia phagocytic activity.

IPC Classes  ?

• A61K 31/26 - Cyanate or isocyanate estersThiocyanate or isothiocyanate esters
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Provided herein are compositions and methods for characterizing and treating cancer. In particular, provided herein are compositions and methods for identifying subjects with breast cancer with increased likelihood of bone metastasis and providing treatment to prevent such metastases.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.

IPC Classes  ?

• C07K 7/14 - AngiotensinsRelated peptides
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
• A61K 38/08 - Peptides having 5 to 11 amino acids
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 9/00 - Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequenceDerivatives thereof

Abstract

Polymers based on a poly(β-amino) ester (PBAE) backbone are provided, with improved targeting of the lung endothelium following parenteral delivery. The disclosed polymers are polymers of a primary amine (A2), a secondary amine (A1), a diacrylate (D) and at least one end-capping hydrophilic compound (C) such as amine. The polymer is halogenated (hereinafter, halogenated PBAE polymer), preferably, fluorinated. The hydrophobic PBAE backbone is end capped with a hydrophilic compound by covalent attachment of these capping agents to the PBAE backbones via Michael Addition to form a halogenated PBAE. The disclosed polymers can be used to encapsulate/incorporate an active agent for targeted delivery to lung endothelial cells.

IPC Classes  ?

• C08G 73/02 - Polyamines
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 9/51 - Nanocapsules
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

A model and testing device for creating repetitive, rotational head trauma in rodents is disclosed herein. The testing device induces angular rotational acceleration and deceleration forces that result in injury or insult to the integrity of the intracranial tissues of the brain for the test animal and can be used to characterize, test the effects of, and/or investigate a therapeutic agent for rotational traumatic brain injury. In some embodiments, the testing device contains an animal restraint that is configured to secure the animal therein, while allowing the animal's head to rotate about the coronal plane during and following impact. The testing device can include an animal restraint, a restraint mount, configured to receive the animal restraint, a helmet assembly attached to the subject restraint mount, such that the helmet assembly is in pivotal rotation about a central axis of rotation, a pendulum arm, and an impact fixture.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A01K 1/03 - Housing for domestic or laboratory animals

Abstract

A composition includes a polymer that is a reaction product of a co-monomer and one or more of elemental sulfur or a chalcogenide halide, wherein the co-monomer includes a vinyl monomer, isopropenyl monomer, acryl monomer, methacryl monomer, unsaturated hydrocarbon monomer, epoxide monomer, thiirane monomer, alkynyl monomer, diene monomer, butadiene monomer, isoprene monomer, norbornene monomer, amine monomer, thiol monomer, sulfide monomer, alkynyl unsaturated monomer, nitrone monomer, aldehyde monomer, ketone monomer, ethylenically unsaturated monomer, styrenic monomer, or a mixture of any two or more thereof; and the co-monomer comprises one or more deuterium atoms.

IPC Classes  ?

• G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
• C08L 25/08 - Copolymers of styrene

Abstract

An optical light propagator is provided, having a core formed of a high-κ dielectric material capable of transmitting wavelengths in the UV-visible range, and an outer coating on the core wherein the outer coating is formed of a low- κ dielectric material; wherein the outer coating has a plurality of porosities along the optical light propagator, wherein each of the plurality of porosities transits from an outer surface of the outer coating to an outer surface of the core at an interface between the outer coating and the core, such that wavelengths transmitted through the core of the optical light propagator are emitted through each of the plurality of porosities along the optical light propagator, and fibers, sheets, yarns, and articles made therefrom.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding

Abstract

Various examples are provided related to a human-robotic mimetic haptic control framework. In one example, a method for human-robotic mimetic haptic control includes obtaining tool operation data associated with a skilled user operating a tool during execution of an application process and training a robotic system to mimic operation of the tool based upon the tool operation data. In another example, a system for human-robotic mimetic haptic control includes one or more sensor(s) that can obtain tool operation data associated with a skilled user operating a hand tool during execution of a construction process and a computing device that can train a robotic system to mimic operation of the hand tool based upon the tool operation data.

IPC Classes  ?

• G06N 3/02 - Neural networks
• G06N 3/08 - Learning methods

Abstract

A method of producing a plurality of optical components, each having a substantially equivalent optical surface, includes providing a substrate of optical material, the substrate having an optically smooth surface; providing a mandrel having an optically smooth surface of a shape that is an inverse of a shape to be imparted to the optically smooth surface of the substrate; coating the optically smooth surface of the mandrel with a mold release material; changing a temperature of at least one of the substrate or the mandrel to be at a substantially same temperature; disposing the substrate on the mandrel such that the optically smooth surface of the substrate is on the optically smooth surface of the mandrel that is coated with the mold release material; heating the mandrel and the substrate together to soften the substrate to conform the optically smooth surface of the substrate to the shape of the mandrel; cooling the mandrel and the substrate together until the substrate is sufficiently rigid to maintain the optically smooth surface of the substrate as conformed to the shape of the mandrel; removing the substrate from the mandrel to provide a first optical component of the plurality of optical components; providing at least one additional substrate of optical material, each having an optically smooth surface; and repeating at least the changing a temperature, disposing, heating and removing for each at least one additional substrate to thereby produce the plurality of optical components. A telescope includes a plurality of the optical components.

Abstract

Differential expression of specific leukocyte genes involved in canonical pathways of neuroinflammation, oxidative stress, and lipid peroxidation, GABA (γ-aminobutyric acid) inhibition, and AMPA and NMDA receptor signaling is able to predict the severity of temporal lobe epilepsy (TLE). For example, high seizure frequency-TLE is distinguished prognostically from low seizure frequency-TLE by differentially increased specific leukocyte gene expression involved in GABA inhibition and NMDA receptor signaling. Thus, high and low seizure frequency patients represent two mechanistically different forms of temporal lobe epilepsy based on leukocyte gene expression and potentially require distinct treatments.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present disclosure provides a continuous power delivery system for implantable devices, including: a wearable device configured to be worn on a patient's body, the wearable device configured to communicate with a power transmitter and receive a first power signal via a first communication protocol, the wearable device including battery management circuitry to a control a charging of a battery using the first power signal and to control a discharge of the battery to generate a second power signal; the wearable device further configured to communicate the second power signal via a second communications and powering protocol; and an implant device configured to be implanted in the patient's body, the implant device configured to communicate with the wearable device and receive the second power signal via the second communications and powering protocol, the implant device include one or more implant components configured to be powered by the second power signal.

Abstract

Perceptual-driven foveated head-mounted display system, in which the angular pixel density decreases with an increase of field eccentricity according to a specified angular pixel density function. Minimally perceivable image artifacts and image resolution discontinuity can result optionally eliminating or limiting the need for an eyetracker or scanning mechanism. To simultaneously see a virtual image rendered by a display and a view of a real-world scene, a freeform prism is utilized as the optical combiner to merge the optical paths of the virtual image display and real-world view. Shapes of the optical surfaces of the freeform prism is controlled to yield spatially varying optical power to achieve a spatially varying angular pixel density distribution for a virtual display path. Exemplary designs yield a total field of view of over 80° while achieving a peak resolution of 2 arcminutes per pixel through a display panel of about 1900 by 1200 pixels.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G02B 27/09 - Beam shaping, e.g. changing the cross-sectioned area, not otherwise provided for
• G02B 5/04 - Prisms
• H04N 13/111 - Transformation of image signals corresponding to virtual viewpoints, e.g. spatial image interpolation
• H04N 13/332 - Displays for viewing with the aid of special glasses or head-mounted displays [HMD]
• G02B 25/00 - EyepiecesMagnifying glasses
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06T 15/06 - Ray-tracing
• G06T 19/00 - Manipulating 3D models or images for computer graphics

Abstract

Soybean, one of the world's most significant protein and oil crops, has been enhanced through genetic engineering and mutagenesis to introduce or enhance agronomic traits. Both transgenic modification and mutagenesis have shown considerable variation in phenotypes observed in crop species. The effects of these methods on soybean seed composition and gene expression were determined by subjecting stable transgenic soybean lines to mutagenesis, generating 100 mutagenized lines with altered GFP expression, which were subsequently analyzed for protein and oil content.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• A01H 4/00 - Plant reproduction by tissue culture techniques
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host

Abstract

This invention is in the field of medicinal chemistry and drug delivery. In particular, the invention relates to compositions comprising bioavailability (e.g., oral and local bioavailability) enhancing ionic liquid formulations and the use thereof for treating conditions or diseases in a subject.

IPC Classes  ?

• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 9/107 - Emulsions
• A61P 31/10 - Antimycotics
• A61P 31/18 - Antivirals for RNA viruses for HIV
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses
• A61P 33/00 - Antiparasitic agents
• A61P 35/00 - Antineoplastic agents
• A61K 31/133 - Amines, e.g. amantadine having hydroxy groups, e.g. sphingosine
• A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim

Abstract

A method for measuring a shape of a reflector surface of a heliostat at night using a bright star at different elevation and azimuthal settings according to an embodiment of the current invention includes setting the heliostat in fixed orientation such that aberrated and overlapping star images formed are translated due to Earth's rotation in a translation direction across the heliostat array receiver; viewing images of the bright star using a fixed array of cameras placed at or near an array receiver of the heliostat, wherein each camera of the fixed array of cameras has a large aperture lens, and simultaneous exposures are made quickly enough and repeated for long enough, so that, as they translate past the cameras, the aberrated star image is fully sampled in two dimensions, and wherein every point on the reflector surface of the heliostat appears in one or more of the recorded images as being bright from reflected starlight; and processing the recorded images from the fixed array of cameras with a data processor to obtain the surface shape by integration of the surface slopes.

IPC Classes  ?

• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
• F24S 50/20 - Arrangements for controlling solar heat collectors for tracking

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of oral bioavailability enhancing formulations of anthelmintic benzimidazole (e.g., oxfendazole) compounds. In particular, the present disclosure provides methods for treating or preventing infectious diseases with one or more oral bioavailability enhancing formulations of anthelmintic benzimidazole (e.g., oxfendazole) compounds, or pharmaceutically acceptable salts thereof, or compositions comprising the same and an additional anti-fungal agent, and pharmaceutical compositions comprising one or more oral bioavailability enhancing formulations of anthelmintic benzimidazole (e.g., oxfendazole) compounds and at least one additional anti-fungal agent.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 9/107 - Emulsions
• A61P 31/10 - Antimycotics
• A61P 33/10 - Anthelmintics

Abstract

Computed tomography image reconstruction uses neural field algorithms to reconstruct images for breast cancer screening and diagnosis. An Attenuation Field Network (AFN) uses x-ray liner attenuation coefficients that form the basis for CT images as a continuous function of imaging volume coordinates. The AFN uses a fully connected network trained on attenuation measurements, captured using a limited number of X-ray projections through an image volume, to learn a continuous function that maps each volumetric coordinate within the image volume to its respective attenuation coefficient. The AFN renders the entire attenuation field or synthesizes high-fidelity projections that are acquired or unacquired. The synthesized projections may be combined with existing projections to yield denser or complete projection data that may be used by other image reconstruction methods

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• A61B 6/40 - Arrangements for generating radiation specially adapted for radiation diagnosis
• A61B 6/42 - Arrangements for detecting radiation specially adapted for radiation diagnosis
• G06N 3/02 - Neural networks
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

π phase jump rotation operationresult of a transformation from the target operation result of the transformation from the π phase jump rotation operationresult of the transformation from the π phase jump rotation operation.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena
• G06N 3/048 - Activation functions
• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms

Abstract

4211-aldehydes in MCRs to afford products in high yield with no deuterium scrambling.

Abstract

Exemplary materials, methods and techniques disclosed and contemplated herein generally relate to methods for synthesizing α-deuterated α-amino acids and their derivatives.

Abstract

Methods, devices and systems are described to eliminate or reduce unwanted polarization aberrations associated with interference filters. An example method for producing a polarization aberration compensator for a thin film interference filter includes obtaining a set of Mueller matrix values based on polarization measurements of the thin film interference filter over a spectral range, and generating a metric based on a difference between a compensated Mueller matrix and an identity matrix over the spectral range. The compensated matrix represents a cumulative Mueller matrix for a combination of the thin film interference filter and the polarization aberration compensator. A configuration of the polarization aberration compensator is determined based on evaluating the metric that eliminates or reduces the difference between the compensated Mueller matrix and the identity matrix over the spectral range. Configuration parameters, including thicknesses of birefringent layers, fast-axis angles and the number of birefringent layers in the compensator are obtained.

IPC Classes  ?

• G02B 5/30 - Polarising elements
• G02B 5/28 - Interference filters

Abstract

The present disclosure concerns methods and compositions for inhibiting replication of viruses within an organism in need thereof. In some cases, the methods and compositions can be applicable to aquacultured organisms. The aquacultured organisms can include, but are not limited to, crustacean organisms such as shrimp.

IPC Classes  ?

• A61K 38/46 - Hydrolases (3)
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

e.g. e.g. an anion exchange resin and a cation exchange resin. The clean dialysate can be pumped into the inlet for the dialyzing machine, or into a storage tank. Optionally, following cleaning, the levels of electrolytes are measured, if needed additional electrolytes are added to the cleaned dialysate to provide the desired levels of electrolytes in the cleaned dialysate.

IPC Classes  ?

• B01D 61/24 - Dialysis
• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
• A61M 1/28 - Peritoneal dialysis
• B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties

Abstract

Microfluidic devices, organ-on-a-chip platforms (e.g. mimicking the human prostate gland), and uses thereof are described herein. The microfluidic device includes at least two layers and a porous membrane therebetween. Each layer includes a channel, and the first channel and the second channel are aligned such that a first region of a first channel overlaps with a region of the second channel, and a second region of the first channel does not overlap a second region of the second channel. A disease model using the microfluidic devices includes (i) placing a first type of cells in the first channel and (ii) flowing a first cell culture medium through the first channel. Optionally, in step (i) a second type of cells in the second channel and in step (ii) a second cell culture medium flows through the second channel. The microfluidic devices can be used in drug screening and testing.

Abstract

Provided herein are compositions and methods for diagnosing, prognosing, and treating neurodegenerative diseases in a male and female subject at risk of or diagnosed with a neurodegenerative disease. In particular, provided herein are customized metabolite analyses for characterizing and treating neurodegenerative diseases in specific subject groups from a sample from said subject.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

A method of regenerating a symmetrical redox flow battery includes: a first discharge process having a duration in which a capacity of the redox flow battery in a first polarity and comprising a membrane decreases from a first to a second capacity, the process comprising: flowing a catholyte through a catholyte compartment in the first polarity; flowing an anolyte through an anolyte compartment in the first polarity; wherein: the first polarity of the redox flow battery includes a membrane having a first face in fluid communication with the catholyte compartment and a second face in fluid communication with the anolyte compartment; and the first and the second faces of the membrane being opposing surfaces of the membrane; and a second discharge process comprising: reversing the polarity of the catholyte and anolyte compartments wherein: the redox flow battery in the second polarity exhibits an initial increased capacity compared to the second capacity from the first discharge process.

IPC Classes  ?

• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells
• H01M 8/0289 - Means for holding the electrolyte

Abstract

A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body

Abstract

Improved antibodies for detection of phosphorylated RBL1, H1.5, LARP6, SUV39H1, and FAM53C have been developed. Assays using them to detect the biomarkers: P-T143 FAM53C, P-T202 LARP6, P-S988 RBL1, P-S17 H1.5, and P-S391 SUV39H1, and diagnostic and prognostic applications stemming therefrom are also provided.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• G01N 33/537 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61P 35/00 - Antineoplastic agents

Abstract

An optical beam is provided from a transmitter aperture to a receiver aperture that receives the optical beam after displacement by a path shifting component. Received initial displacement information characterizing at least one of: an initial estimate of the displacement, or an indication that the displacement is below a predetermined threshold. Received input beams each have a different spatial mode, from a set of mutually orthogonal spatial modes that include: a lowest order spatial mode, a highest order spatial mode, and one or more intermediate order spatial modes. A relative amount of each of the input beams to be included in the optical beam is determined based at least in part on: corresponding diffraction loss estimates for each of the input beams, and the initial displacement information. One of the input beams that has a largest relative amount in the optical beam is one of the intermediate order spatial modes.

IPC Classes  ?

• G01S 7/48 - Details of systems according to groups , , of systems according to group
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• H04B 10/112 - Line-of-sight transmission over an extended range
• H04B 10/70 - Photonic quantum communication

Abstract

Acoustic wave devices, structures and methods are described that reduce or eliminate return losses due to reflections caused by impedance mismatch. The described features and benefits are achieved without increasing the footprint of the device and improve the power budget of the acoustic wave device. An example acoustic wave device includes an input transducer, an acoustic material, and an output transducer. The acoustic material includes a number of unit cells, each having a first layer and a second layer with differing materials. Impedance values associated with the input layer, the detection layer, and/or one or both of the first layer or the second layer of the unit cells are selected to allow the input acoustic wave to propagate within the acoustic material in a first direction with substantially no backscattered acoustic waves in the opposite direction.

IPC Classes  ?

• G01N 29/00 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
• G10K 11/00 - Methods or devices for transmitting, conducting or directing sound in generalMethods or devices for protecting against, or for damping, noise or other acoustic waves in general
• H03H 9/24 - Constructional features of resonators of material which is not piezoelectric, electrostrictive, or magnetostrictive
• H04R 3/12 - Circuits for transducers for distributing signals to two or more loudspeakers

Abstract

Methods, devices and systems for generating shaped, synthetic light patterns based on measured optical signals are described that are subsequently processed to generate the desired synthetic fields. By combining synthetic fields with particular amplitude, phase and/or spectral values, a desired synthetic light illumination pattern can be conceived based on the measured optical signals. The synthetic fields can then be computationally propagated in time and space to understand the characteristics of the propagated light and/or characteristics of the intervening objects.

IPC Classes  ?

• G01S 17/34 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated using transmission of continuous, frequency-modulated waves while heterodyning the received signal, or a signal derived therefrom, with a locally-generated signal related to the contemporaneously transmitted signal
• G01S 17/88 - Lidar systems, specially adapted for specific applications
• G01S 17/10 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01S 7/4912 - Receivers

Abstract

Entanglement is a unique quantum information processing (QIP) feature. Entanglement can be used to implement quantum sensors with improved sensitivity over classical sensors. Disclosed are systems and techniques for entanglement distribution over turbulent free-space optical (FSO) channels based on using adaptive optics. An apparatus can include a C-band tunable laser, amplifier, and periodically poled lithium niobate (PPLN) waveguide for generating entangled photon pairs. The entangled photon pairs are multiplexed with a classical laser beam and transmitted over a free-space optical (FSO) link. A reflected beam from an intermediate node, or a direct beam from a remote transmitter with line-of-sight, is received and provided to an adaptive optics (AO) system using the classical signal as a channel probe to determine a correction. The received beam is further reflected by a deformable mirror to apply the correction. The entangled photon pairs are demultiplexed from the received beam and provided to intended users.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• H04B 10/70 - Photonic quantum communication
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals

Abstract

Disclosed are systems and techniques for covert and/or low probability to intercept communications using thermal source-based signaling. A transmitter can generate a modulated signal by modulating a low-density parity check (LDPC)-coded modulation signal on an amplified spontaneous emission (ASE) noise source signal. The modulated signal can be amplified by one or more Erbium-Doped Fiber Amplifier (EDFA) amplification stages. A noise-masked signal can be generated by combining the modulated signal with an added noise signal from an additional EDFA, and can be transmitted to a receiver via a free-space optical (FSO) link. A receiver can apply adaptive optics (AO) corrections to the received noise-masked signal and apply a narrowband filter. The transmitted signal can be detected from the narrowband filtered signal by using a balanced detector and a local laser, wherein the balanced detector uses a beam from the local laser to perform heterodyne detection.

Abstract

A 3D PE/PAT imaging system and probe device includes a tissue coupling interface that enables closed-loop volumetric ultrasound and photoacoustic imaging and spectroscopy that does not depend on the operator. In addition to a probe device that incorporates light and sound signals into a coaligned axis for application to a target tissue area, the imaging system includes a volumetric scanning subsystem including a motor and a housing for the motor, the motor mechanically engaged with the probe device to actuate the probe device along a linear axis associated with a surface of the target tissue area for volumetric scanning. The tissue coupling interface includes a receiver plate that can magnetically interface with a tissue coupler element positionable around the target tissue area to minimize movement of the target tissue area, allow for hands-free operation and improve reproducibility of data generated by the imaging system.

IPC Classes  ?

• A61B 8/14 - Echo-tomography

Abstract

Improved membranes for various devices including encapsulation devices and delivery devices are provided. Membranes of the present disclosure provide various combinations and layers of structures and features shown and described herein. In some embodiments, a spacing is provided between certain layers to enhance vascularization of the device. The present disclosure further provides devices for delivery of drugs, agent, and for housing cells.

IPC Classes  ?

• A61F 2/02 - Prostheses implantable into the body
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61L 27/14 - Macromolecular materials
• A61L 27/38 - Animal cells
• A61L 27/56 - Porous or cellular materials
• A61L 31/14 - Materials characterised by their function or physical properties
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61M 5/142 - Pressure infusion, e.g. using pumps
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

Surgical training devices, kits, and associated methods are disclosed. The surgical training devices include a body shaped to correspond to an animal. The surgical training devices also include an insert for removable insertion into an opening in the body. The insert can be to be covered by a cover, which can be removably attached to the insert. An entirety or majority of the body, the insert, and the cover can be formed of materials sourced from sources other than the animal.

IPC Classes  ?

• G09B 23/34 - Anatomical models with removable parts

Abstract

Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). The present invention reveals that quinacrine directly binds to G4 RNAs found in genomic RNA of the COVID-19 virus, showing antiviral activity against COVID-19 using in vitro cell culture systems. An object of the present invention is thus a new pharmaceutical composition of quinacrine for the treatment of COVID-19. Another object of the invention is a method for administering quinacrine by various routes specifically for treatment, including oral administration, sterile intravenous injection, and others.

IPC Classes  ?

• C07D 219/12 - Aminoalkyl-amino radicals attached in position 9
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 31/14 - Antivirals for RNA viruses
• C07D 219/10 - Nitrogen atoms attached in position 9
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Inositol monophosphatase 1 (IMPA1) controls the activity of the primary cell proliferation signaling cascades activated through the inositol-dependent phosphorylation of Akt and PKCs. Furthermore, IMPA1-mediated control of cell proliferation involves the recruitment of cytosolic IMPA1 on a plasma membrane by the receptor for advanced glycation endproducts (RAGE). Interaction between IMPA1 and RAGE redistributes inositols from the cytosolic pool to membrane microdomains and amplifies the synthesis of membrane-bound phosphatidylinositols (PtdIns) to trigger inositol-dependent cell proliferation. Thus, the peptide compositions described herein inhibit the formation of the complex between IMPA1 and RAGE (e.g., a pathogenic complex) to control over-proliferative cells.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61P 9/12 - Antihypertensives

Abstract

An optical arrangement includes an optical printed circuit board (OPCB) having at least a first optical waveguide having a first end located on the OPCB. The optical arrangement also includes at least one photonic integrated circuit (PIC) mounted to the OPCB. The PIC includes a second optical waveguide. The first waveguide has a second end located on a portion of the second waveguide to optically couple light between the PIC and the first waveguide. The portion of the second waveguide on which the second end of the first waveguide is located has an inverse taper. The inverse tapered portion is defined by a plurality of segments. The segments of the inverse tapered portion each have a length and a taper rate that causes each segment to make an equal contribution to any radiation losses in the mode transformation of light being coupled between the first and second waveguides.

IPC Classes  ?

• G02B 6/122 - Basic optical elements, e.g. light-guiding paths
• G02B 6/02 - Optical fibres with cladding
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/126 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind using polarisation effects
• G02B 6/14 - Mode converters

Abstract

Methods and systems of preserving, treating and monitoring organs, tissues and implants are provided. In some embodiments, systems are provided that comprises a closed terminus and a substantially sealed system and wherein a parameter is detected in order to selectively control a flow of fluid to the system. Methods and system for preserving organs are provided with reduced material needs, improved energy efficiencies, and enhanced organ preservation are provided.

Abstract

Methods and print head configurations for fabrication of complex three-dimensional (3D) structures using anisotropic materials are described. One example 3D print head includes a tubular channel configured to receive an anisotropic material, and to allow the anisotropic material to move therein, and a chamber configured to heat the anisotropic material. The 3D print head also includes one or more electrodes positioned to at least partially surround a section of the tubular channel, where the one or more electrodes are configured to receive one or more voltages to establish an electric field across the tubular channel, and the one or more voltages are selectable to allow the electric field having a magnitude and direction to be established across the tubular channel.

Abstract

Conventional moving control surfaces on a typical tailless aircraft are replaced with sweeping Jet Actuators ("SJAs") for Active Flow Control ("AFC"). However, a large quantity of SJAs may be necessary in each array and efficacy of SJAs has only been demonstrated at low speeds (i.e., Mach 0.2 or less). In this disclosure, Supersonic Steady Jets (SSJs) are used as control surface replacements for aircraft. The SSJs are distributed on the aircraft in locations and orientations that take into consideration changing local flow conditions on the surface of the aircraft. In one example, when a single SSJ was used to control the pitch of the aircraft, the single SSJ increased the trimmed lift of the aircraft almost as well as an array of SJAs, while providing better yaw control at a small accompanying rolling moment.

Abstract

Several novel peptides to block various signaling domains of APN are disclosed. The peptides disclosed interrupt the action of APN (aminopeptidase N peptide) for the treatment of viral (i.e. covid) infections and PAH. The interruption is specifically accomplished by binding an antagonist/inhibitor (i.e. peptide, antibody, small molecule) to the intracellular portion of the APN.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A system including a combination of a photobioreactor fluidly coupled to a particle filtration system is provided. Also provided are methods of cultivating Coccolithophores in the system, which can be used to capture carbon dioxide in the culture medium into calcium carbonate.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

The present disclosure provides a wearable article including a 3D printed base, 3D printed antenna ground plane structure and a 3D printed a dipole antenna structure, wherein the base, ground plane structure and dipole antenna structure comprises a 3D printed mesh which is formed of a stretchable elastomeric polymer material. The wearable article also includes signal transmission and power harvesting circuitry comprising duplexing circuit to transmit and receive data and to receive wireless power from a power transmission unit.

Abstract

Methods for treating, ameliorating and/or preventing progression of cardiomyopathy and heart failure by drugs that reduce or inhibit Factor XII and/or activated Factor XII (collectively FXII(a)), diagnosing, and/or screening for Factor Xll(a)-inhibiting/suppressing drugs for heart failure and/or cardiomyopathy by detecting biomarkers selected from a group consisting of one or more of plasma renin activity (PRA), soluble pro-renin receptor (s(P)RR) and/or coagulation Factor XI la (FXII(a)). Reduction of Factor Xll(a) levels and/or activity is effective for treating, ameliorating and/or preventing progression of cardiomyopathy and/or heart failure in the subject.

Abstract

A polarimetric endoscope includes an insertion tube and a polarization imaging channel. The polarization imaging channel includes (i) an imaging fiber bundle having a plurality of optical fibers and being at least partially in the insertion tube, (ii) an imaging lens at a distal tube-end, of the insertion tube, that forms an image at a distal bundle-end of the imaging fiber bundle, and (iii) a polarizer array having a plurality of polarizers each aligned to a distal end of a respective one of the plurality of optical fibers and transmitting one of a plurality of polarization states. Each of the imaging fiber bundle and the first and second illumination channels is at least partially in the insertion tube.

IPC Classes  ?

• G02B 23/26 - Instruments for viewing the inside of hollow bodies, e.g. fibrescopes using light guides
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
• G02B 5/30 - Polarising elements
• G02B 23/24 - Instruments for viewing the inside of hollow bodies, e.g. fibrescopes

Abstract

Methods and devices are described that relate to eyewear that are specifically designed to allow emissions of circadian-active green light to reach the observer. An example wearable device includes one or more windows positioned to allow light from a light source to propagate toward a position of a wearer's eyes. and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number thicknesses of the layers are selected to provide designed transmission and blocking characteristics to allow circadian-active spectra to pass through while blocking spectral content other than the circadian-active spectra. The filter characteristics include one contiguous transmission region to transmit 98%-100% of a precisely-selected green region and two contiguous blocking regions that block 80-100% of the remaining spectral content.

IPC Classes  ?

• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses
• G02C 11/04 - Illuminating means

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a tetrahydroacridine (or similar) structure, an acridine (or similar) structure, a benzonaphthyridine (or similar) structure, or a tetrahydrobenzonaphthyridine (or similar) structure which function as autophagy inhibitors and/or histone deactylase inhibitors, and their use as therapeutics for the treatment of conditions characterized with aberrant autophagy activity and/or aberrant HDAC activity (e.g., cancer, pulmonary hypertension, diabetes, neurodegenerative disorders, aging, heart disease, rheumatoid arthritis, infectious discuses, conditions and symptoms caused by a viral infection (e.g., COVID-19)).

IPC Classes  ?

• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 11/00 - Drugs for disorders of the respiratory system
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Infectious diseases pose persistent threats to the health and wellbeing of humans and animals globally. Systems and methods for multi omics-based validation of gene expression data have been developed. The methods assess disease/infection/immunity data and identify treatment regimens most likely to yield beneficial patient outcomes. The methods are implemented in a computational program for integrated, queryable pathogen/host atlas of CDC “Urgent Threat” Pathogens. Methods of treatment for disease/infection/immunity using active agents according to the described methods are also provided. In some forms, the systems and methods determine optimal treatment regimens for subjects infected with Clostridioides difficile, or Neisseria gonorrhoeae. Exemplary subjects include farm animals and humans.

IPC Classes  ?

• G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae

Abstract

Provided are methods of treating a biological system with a gas marble, including related methods of making a gas marble from an identified gaseous chemical compound from a planetary source, including a planetary atmosphere. The collected gaseous chemical compound can be activated with a liquid having an assembly of composite nanomaterials to form stable gas marbles that are, in turn, used with a treatment method. Also provided are stable marbles gases useful in applications related to biological systems, including health-related applications by medical gas therapy.

IPC Classes  ?

• A61M 16/10 - Preparation of respiratory gases or vapours
• A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases

Abstract

Methods and devices are described that relate to spectral filters and associated eyewear that are specifically designed to block emissions of circadian-active blue light to reach the observer. An example wearable device that includes one or more windows, and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-active spectra while allowing spectral content outside of the circadian-active spectra to pass through the spectral filter. The spectral filter further includes an additional layer to effectuate a particular color such as the color pink.

IPC Classes  ?

• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses
• G02B 5/28 - Interference filters
• G02C 9/04 - Attaching auxiliary optical parts by fitting over or clamping on

Abstract

Provided herein are devices for self-testing for a plurality of biomarkers from a liquid biofluid sample. and related methods of using the devices to test for the biomarkers presence or absence. The devices comprise a specially configured vertical flow biosensor to provide a device platform that is safe and can be used at-home/in the field without need for any specialized equipment or external power sources.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Generation of a non-Gaussian quantum state uses a quantum optical frequency comb source comprising at least one nonlinear optical medium and providing spectral modes including a plurality of pairs of entangled spectral modes, each pair including: a first spectral mode centered at a first frequency, and a second spectral mode entangled with the first spectral mode and centered at a second frequency that is spaced from the first frequency at a multiple of the frequency-bin spacing. Electrically controllable optical transformation modules are connected in series with a first module receiving the spectral modes. Two or more of the modules each comprise: a spectral mode phase shifter applying respective phase shifts to different spectral modes based on at least a first electrical signal, and a spectral mode mixer coupled to the spectral mode phase shifter and coupling spectral modes centered at different frequencies based on at least a second electrical signal.

IPC Classes  ?

• G02F 1/35 - Non-linear optics
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/70 - Quantum error correction, detection or prevention, e.g. surface codes or magic state distillation

Abstract

The adaptive methodology of (purposefully, intentionally aperiodically) poling of an optical waveguide made in a nonlinear material substrate to achieve a continuous increase of overall nonlinear conversion efficiency with increase in the length of such waveguide. As a result of such poling, the variation of at least a waveguide thickness is compensated by adjusting the poling period along the waveguide to match the local momentum difference of the nonlinear process. For a second-harmonic generation, a near-ideal performance of the nonlinear energy conversion process was demonstrated even for a 21 mm long waveguide (with the SHG efficiency as high as 9415%/W and a 82.6% absolute power conversion efficiency). The adaptive poling methodology can also be applied to compensate other systematic inhomogeneity of a WG device in, for example, etching depth, diffusion depth, dose of lithographic exposure of the nonlinear material, and doping density across the nonlinear material substrate.

IPC Classes  ?

• G02F 1/355 - Non-linear optics characterised by the materials used
• G02F 1/377 - Non-linear optics for second-harmonic generation in an optical waveguide structure

Abstract

A surgical self-retaining retractor system includes a self-retaining retractor having first and second tissue engaging members that oppose one another and maintain an opening in an incision. First and second force sensors are respectively coupled to the first and second tissue engaging members such that the force sensors detect force being exerted thereon by tissue when the self-retaining retractor is maintaining an opening through the incision.

IPC Classes  ?

• A61B 17/3205 - Excision instruments

Abstract

An optical system for modulating a light beam emitted by a laser light source. The system includes a phase light modulation device positioned to receive the laser light beam, a 4f relay optics positioned to receive light emitted from the phase light modulation device, and having a tilt mirror positioned in the light path, the tilt mirror having a center hole that permits light to pass therethrough and relay to a focusing lens, whereby a modulated and linearly polarized beam is transmitted; a quarter wave plate having a polarized beam splitter positioned to receive the modulated and linearly polarized beam; and a digital micromirror device that includes an array of micromirrors and that modulates amplitude of light in a pixelated manner by redirecting light into two directions, on- and off-directions, by electrically controlling the tilt angle of each micromirror.

IPC Classes  ?

• G02B 26/02 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising

Abstract

Methods for determining laser pulse positions for shaping an optical element may comprise: determining a stress field for at least a portion of a substrate, wherein the stress field comprises at least three components of stress, wherein the stress field comprises a plurality of stress states for the at least a portion of the substrate; determining, based at least on the stress field and a calibration model, a spot density over the at least a portion of the substrate; determining, based on the spot density, a laser spot position allocation that arranges a number of laser pulses into a minimum number of lines that achieves the spot density; and causing, based on the laser spot position allocation, output of a machine program that coordinates a rotation stage, beam shaping, a translation stage, and a laser firing parameter for surface shaping of the at least a portion of the substrate.

IPC Classes  ?

• B23K 26/50 - Working by transmitting the laser beam through or within the workpiece
• B23K 26/0622 - Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
• B23K 26/08 - Devices involving relative movement between laser beam and workpiece
• B23K 103/00 - Materials to be soldered, welded or cut
• G01L 5/16 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring several components of force

Abstract

A networked system architecture including hardware and software elements permits data transmission between underwater systems. The network architecture includes data transmission between underwater computers, instruments, robotic vehicles, human-occupied underwater habitats, and/or worn sensor devices. Data is transmitted over wired communication channels, wireless communication channels, or a combination thereof. The network is established independent of surface connectivity (e.g., a topside connection) and creates a Local Area Network (LAN) or Wide Area Network (WAN) specific to an underwater environment. A system administrator, such as a diver, operates an underwater and waterproof computer to control and operate an underwater and waterproof device (e.g., a robotic vehicle) over the LAN/WAN. The underwater device may be a remotely operated vehicle (ROV), an autonomous underwater vehicle (AUV), a drifting sensor, a moored sensor, or the like.

IPC Classes  ?

• G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme

Abstract

A large balloon reflector, capable of launching and support itself at high altitudes, with a feed system capable of steering the beam quickly enough to perform target tracking of fast-moving terrestrial, stratospheric, or orbiting objects. The large balloon reflector antenna forms a suborbital antenna system that is suitable for operation from radio to infrared wavelengths and can be used, for example, for remote sensing of objects on the ground, in the atmosphere, or in space.

IPC Classes  ?

• H01Q 1/08 - Means for collapsing antennas or parts thereof
• B64U 10/60 - Tethered aircraft
• B64U 101/00 - UAVs specially adapted for particular uses or applications
• G01C 21/16 - NavigationNavigational instruments not provided for in groups by using measurement of speed or acceleration executed aboard the object being navigatedDead reckoning by integrating acceleration or speed, i.e. inertial navigation
• H01Q 15/16 - Reflecting surfacesEquivalent structures curved in two dimensions, e.g. paraboloidal