Abrégé

en faceen face, integration of a display as part of the microscope, increased signal level and imaging speed, reduction of detected specular reflection, and attachment methods onto a slit lamp biomicroscope or for hand-held use.

Classes IPC  ?

• A61B 3/12 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p. ex. ophtalmoscopes
• A61B 3/14 - Dispositions spécialement adaptées à la photographie de l'œil
• G02B 27/09 - Mise en forme du faisceau, p. ex. changement de la section transversale, non prévue ailleurs
• G02B 27/30 - Collimateurs
• G02B 5/18 - Grilles de diffraction
• G06T 7/11 - Découpage basé sur les zones
• G02B 5/30 - Éléments polarisants

Abrégé

Example embodiments disclosed herein include a method of preparing a resin for three-dimensional (3D) printing of a glass component based on two-photon polymerization (TPP). The method comprises: forming a first mixture comprising a monomer, a first liquid, and a second liquid; using an F- catalyzation mechanism to form a resin, based on the first mixture and comprising silsesquioxane, that is fully hydrolyzed and condensed; and purifying the resin by filtering the product.

Classes IPC  ?

• B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
• B29C 65/02 - Assemblage d'éléments préformésAppareils à cet effet par chauffage, avec ou sans pressage
• B29C 71/02 - Post-traitement thermique
• B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes
• C08G 77/04 - Polysiloxanes

Abrégé

A device for collecting a sample includes a tube having an open end and a second end having dropper tip for dispensing the sample; and a filter or analyte manipulation device in the tube adjacent to the dropper tip. Various components may be attached to the tube to facilitate collecting and dispensing a sample, include a funnel, a plunger and a separate dropper tip. The device may be used with a swab or a fluid solution.

Classes IPC  ?

• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Abrégé

Example embodiments disclosed herein include an optical system for image acquisition and projection, comprising: an illumination path including a first lens configured to receive infrared light and to direct the infrared light towards a sample; an imaging path including: a first beam splitter, a second lens configured to receive fluorescence light produced by the sample in response to illumination by the infrared light and to direct the fluorescence light towards the first beam splitter, and an imaging sensor configured to capture the fluorescence light after passing through the first beam splitter; and a projection path including a pixelated light source configured to project an image towards the sample using visible light, the image associated with the fluorescence light captured by the imaging sensor, the visible light passing through both the first beam splitter and the second lens.

Classes IPC  ?

• A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
• G01N 21/64 - FluorescencePhosphorescence
• G03B 15/14 - Procédés particuliers pour prendre des photographiesAppareillage à cet effet pour prendre des photographies pendant les opérations médicales
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

A hybrid lateral flow test device for detecting a target analyte in a sample includes an enclosed channel with a test area for binding to the target analyte. The channel is a microfluidic channel having an upstream opening and a downstream opening, an upstream wicking area abutting the upstream opening of the channel, a downstream absorbent pad abutting the downstream opening of the channel, a sample receiving area upstream of or encompassing the wicking area, and labeled conjugates for binding with the target analyte upstream of the test area.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/558 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant la diffusion ou la migration de l'anticorps ou de l'antigène
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières

Abrégé

A platform that uses artificial intelligence and machine learning (AI/ML) to integrate wearable sensor data to detect shifts in the underlying biology that signals when the body is getting ready for labor and before symptoms (e.g., contractions) become prevalent. Shift detection may leverage a multimodal distribution of physiological markers. Physiological markers may include, for example, body temperature, heart/respiration or heart rate variability, sleep, circadian or ultradian patterns, caloric expenditure/activity, etc. A predicted time before delivery may give the user a due date that is based on real-time physiological data gleaned from a wearable device.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients

Abrégé

22222 flow measurements.

Classes IPC  ?

• B01D 53/96 - Régénération, réactivation ou recyclage des réactifs
• B01J 20/34 - Régénération ou réactivation
• C01B 32/50 - Anhydride carbonique
• F24S 23/70 - Agencements pour concentrer les rayons solaires pour les collecteurs de chaleur solaire avec des réflecteurs
• B01D 53/83 - Procédés en phase solide avec des réactifs en mouvement

Abrégé

A technique, called the Coupling Assay for T-cell Specificity (CATS), to identify antigen-specific cells using cell lines expressing MHC II molecules with tethered peptides. CATS successfully identified antigen-specific T cells with a low-affinity peptide, while tetramer failed to identify cells with this same peptide. Increasing avidity on artificial antigen presenting cells can overcome low affinity TCR-pMHC interactions, can identify more responding endogenous populations, and may be specific for the MHCII.

Classes IPC  ?

• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A process for purifying an initial water source comprising water and an initial amount of one or more per- and polyfluorinated organics (PFAS), the process comprising the steps of contacting the initial water source with a sorbent composition comprising a sorbent substrate and a surface modifier composition to yield purified water and a waste composition comprising PFAS.

Classes IPC  ?

• B01D 53/70 - Composés halogénés organiques
• B01D 71/10 - CelluloseCellulose modifiée
• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
• B01J 20/34 - Régénération ou réactivation
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption

Abrégé

Methods and systems for analyzing the architecture of microservice systems using large language models (LLMs) are described. An example method for analyzing an architecture of a microservice system includes generating an intermediate representation that includes a representation of dependencies between a plurality of microservices of the microservice system, and generating, based on the intermediate representation and a general LLM, at least one answer to at least one question associated with the architecture of the microservice system. The method further includes performing, based on the at least one answer, one or more operations that reconfigure at least one microservice of the plurality of microservices. An example system includes one or more processors configured to implement the above-described method.

Classes IPC  ?

• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage
• G06F 9/44 - Dispositions pour exécuter des programmes spécifiques

Abrégé

A heliostat includes a reflector that has at least one segment arranged in a segment assembly and that defines a reflecting surface; a rigid spaceframe structure that includes a plurality of struts joined at nodes, the plurality of struts supporting the segment assembly so as to hold the reflecting surface in a concave toroidal shape; a dual-axis mount constructed and arranged to support and orient the rigid spaceframe structure and the segment assembly so as to reflect sunlight incident on the reflecting surface toward a distant receiving surface, the dual-axis mount including at least two drives; at least one mechanical linkage coupled to at least one drive of the dual-axis mount and configured to change a relative position of at least two nodes of the rigid spaceframe structure in synchronization with motion of the at least one drive, and thereby changing a shape of the rigid spaceframe structure and the reflector.

Classes IPC  ?

• G02B 7/183 - Montures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour prismesMontures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour miroirs pour miroirs spécialement adaptés à de très grands miroirs, p. ex. pour l'astronomie
• F24S 20/20 - Collecteurs de chaleur solaire pour recevoir de l’énergie solaire concentrée, p. ex. récepteurs pour centrales électriques solaires
• F24S 23/74 - Agencements pour concentrer les rayons solaires pour les collecteurs de chaleur solaire avec des réflecteurs avec des surfaces réfléchissantes en forme d’auge ou sous forme cylindro-parabolique
• F24S 30/45 - Agencements pour mouvoir ou orienter des modules de collecteurs de chaleur solaire pour le déplacement en rotation avec deux axes de rotation
• G02B 5/10 - Miroirs à surfaces courbes
• G02B 19/00 - Condenseurs
• G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière

Abrégé

An optical biasing system that injects a synthetic light field into the path provided to an event-based sensor, shifting irradiance levels from low-light regions (where noise events are common) to a higher brightness region with more stable noise rates. In some embodiments, the optical biasing system determines the ambient brightness level of the captured scene and outputs a synthetic (e.g., a temporally varying) light field having an irradiance level selected to optimize the signal-to-noise ratio at the determined ambient brightness level. In some embodiments, the optical biasing system determines the ambient brightness level at each pixel and outputs a light field having spatially varying irradiance levels to optimize the signal-to-noise ratio of each pixel. The disclosed system provides a number of benefits over existing EBS noise correction methods, most notably because the disclosed method does not require modifying sensor hardware or using active algorithms to control sensor parameters.

Classes IPC  ?

• H04N 5/21 - Circuits pour la suppression ou la diminution de perturbations, p. ex. moiré ou halo
• G06V 10/147 - Détails de capteurs, p. ex. lentilles de capteurs
• H04N 23/52 - Éléments optimisant le fonctionnement du capteur d'images, p. ex. pour la protection contre les interférences électromagnétiques [EMI] ou la commande de la température par des éléments de transfert de chaleur ou de refroidissement
• H04N 23/56 - Caméras ou modules de caméras comprenant des capteurs d'images électroniquesLeur commande munis de moyens d'éclairage
• H04N 25/47 - Capteurs d'images avec sortie d'adresse de pixelCapteurs d'images commandés par événementSélection des pixels à lire en fonction des données d'image
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux
• G06V 10/141 - Commande d’éclairage
• H04N 25/707 - Pixels pour la détection d’événements
• H10F 39/15 - Capteurs d’images à couplage de charge [CCD]

Abrégé

SARS-CoV-2 has caused a global pandemic with significant humanity and economic loss since the beginning of 2020. Flaviviruses such as Zika and Dengue viruses are also significant human pathogens. Although SARS-CoV-2 vaccines are effective in preventing severe disease outcomes, they are less effective in controlling infection or re-infection, particularly due to rapid evolution of viral variants of SARS-CoV-2. Currently only limited options are available to treat SARS-CoV-2 and flavivirus infections for vulnerable populations. Potential of a future pandemic of other viruses is high. The present invention features compositions and methods for a universal high throughput screening (HTS) assay to identify inhibitors targeting the S-adenosyl-L-methionine (SAM)-binding site of viral methyltransferases (MTases) using SAM as a methyl donor.

Classes IPC  ?

• A61K 31/12 - Cétones
• A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase

Abrégé

Methods and systems for the automated generation of test coverage metrics for microservice systems are disclosed. An example method for generating test coverage metrics for a test suite comprising multiple tests for a microservice system containing multiple microservices includes generating a first set of endpoints associated with the multiple microservices based on a static analysis of the corresponding microservice source code and a second set of endpoints based on generating traces and capturing interactions during operation of the corresponding microservice. The method further includes integrating the first and second sets of endpoints to generate a combined set of endpoints, and determining, based thereon, the test coverage metrics for the multiple tests. The method then reconfigures, based on the test coverage metrics, at least one of the multiple tests or at least one of the multiple microservices. An example system includes one or more processors configured to implement the above-described method.

Classes IPC  ?

• G06F 11/3668 - Test de logiciel
• G06F 11/34 - Enregistrement ou évaluation statistique de l'activité du calculateur, p. ex. des interruptions ou des opérations d'entrée–sortie
• G06F 8/75 - Analyse structurelle pour la compréhension des programmes
• G06F 11/00 - Détection d'erreursCorrection d'erreursContrôle de fonctionnement

Abrégé

A composition for treating inflammatory, neoplastic and obstructive lung diseases featuring a CC16-derived analog is described herein. The analog may include N-terminal acetylation and C -terminal amidation, enhancing stability. Adopting a helical conformation, the CC16-derived analog maintains activity akin to full-length CC16 protein. Effective for diverse lung diseases, the composition allows aerosolization, subcutaneous injection, and pulmonary delivery, with administration options including nasal inhalation, subcutaneous, or oral routes. A method for treating these diseases involves administering the CC16-derived analog to a subject in need. This innovation offers a versatile, efficacious solution for respiratory conditions, providing tailored treatment approaches.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 19/00 - Peptides hybrides
• A61P 35/00 - Agents anticancéreux

Abrégé

Methods, devices and systems are described that reduce polarization aberration of a metal coated surface. An example optical device includes a multi-layer structure that includes a reflective layer having retardance and diattenuation over a particular range of wavelengths. The multi-layer structure also includes a uniaxial birefringent layer positioned above the reflective layer, and an anti-reflection layer positioned above the uniaxial birefringent layer. The uniaxial birefringent layer's thickness is selected to compensate for at least a portion of the retardance of the reflective layer over the particular range of wavelengths. The anti-reflection layer's thickness is selected to compensate for at least a portion of the diattenuation associated with the reflective layer over the particular range of wavelengths. The uniaxial birefringent layer can be a C-plate, and example reflective layers include an aluminum layer, a silver layer or a gold layer.

Classes IPC  ?

• G02B 5/30 - Éléments polarisants
• G02B 1/116 - Multicouches comportant des couches conductrices électriques
• G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,

Abrégé

This present disclosure is directed to a method of treating mining tailings from mining operations using dust suppression composition disclosed herein.

Classes IPC  ?

• E21F 5/06 - Fluides employés pour la pulvérisation
• C09K 3/22 - Substances non couvertes ailleurs pour abattre la poussière ou pour l'absorber

Abrégé

(i.e.(i.e., realtime) size exclusion chromatography (SEC) operably linked to a charge detection mass spectrometer. The apparatuses contain a device—microcontroller—specifically configured to deliver pulsed injections from a large sample loop onto an SEC for online charge detection-mass spectrometry (CD-MS) analysis. Data showed a series of peaks spaced according to the pseudorandom injection sequence, which were demultiplexed with a Hadamard transform algorithm. The demultiplexed data revealed improved CD-MS signals while preserving the retention time information. This multiplexing approach provides a general solution to the inherent incompatibilities of online separations and CD-MS detection, and can be used in a range of applications.

Classes IPC  ?

• G01N 30/72 - Spectromètres de masse
• G01N 30/20 - Injection utilisant une valve d'échantillonnage
• G01N 30/86 - Analyse des signaux

Abrégé

A dynamic foot brace device for providing arch support to a foot of a user through energy storage at an ankle of the user during a step. The device includes a tension member including a first end coupled to an arch of the foot and a second end coupled to the ankle. The tension member may be configured to store energy from tension applied to the first end during a first phase of the step and release the energy to the foot as a propulsion force when the tension applied to the first end is released during a second phase of the step.

Classes IPC  ?

• A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles

Abrégé

Endometrial cancer (EC) is the most common gynecologic cancer in developed countries and the fourth most common cancer affecting women in the US. In contrast to other cancers, rates of EC continue to rise, and there are indications that social determinants of health and race and/or ethnicity contribute to risk. Thus, the methods described herein provide a non-invasive means of measuring biomarkers in the local cervicovaginal microenvironment. These novel biomarkers may be used for diagnosing and/or predicting women who are "at risk" for the development and progression of endometrial cancer (EC; e.g., EC type 1). Specifically, the methods herein may include obtaining a cervicovaginal lavage (CVL) or vaginal swab sample from a patient and producing a profile of at least five or more biomarkers from the collected sample.

Classes IPC  ?

• G01N 30/72 - Spectromètres de masse
• G01N 33/84 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des composés inorganiques ou le pH
• G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol

Abrégé

Pathogens developing resistance to available drugs are of main concern in various diseases, including cryptococcosis and tuberculosis. Hence there is a need for therapeutics with novel mechanisms of action. Described herein are compositions and methods for treating infections (e.g., fungal infections) caused by microbes (e.g., fungi) comprising inteins. An intein is a moving protein element inside a host protein. Splicing off intein from the host protein is required to maturate and activate the host protein. Calcimycin (CMN) is used as an intein splicing inhibitor to block intein splicing of the Prp8 protein of fungal pathogen C. neoformans and C. gattii the causative agents of cryptococcosis, to treat patients.

Classes IPC  ?

• A61K 31/423 - Oxazoles condensés avec des carbocycles
• A61P 31/10 - Antifongiques

Abrégé

SARS-CoV-2 has raised the alarm to search for effective therapy for this virus. To date several vaccines have been approved, but few available drugs reported recently still need approval from FDA. Antiviral compositions having niclosamide derivatives were prepared for treating COVID-19. Using a FRET-based enzymatic assay, three niclosamide derivatives, JMX0286, JMX0301, and JMX0941, were identified as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values similar to that of known covalent inhibitor boceprevir. In a cell-based antiviral assay, these inhibitors can inhibit the virus growth with EC50 in the range of 2-3 μM. The mechanism of action of JMX0286, JMX0301, and JMX0941 were characterized by enzyme kinetics, affinity binding and protein-based substrate digestion. Molecular docking suggested that JMX0286, JMX0301, and JMX0941 bind specifically to an allosteric pocket of the SARS-CoV-2 3CL protease.

Classes IPC  ?

• A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
• A61K 31/27 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carbamiques ou thiocarbamiques, p. ex. méprobamate, carbachol, néostigmine
• A61K 31/403 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des carbocycles, p. ex. carbazole
• A61K 31/4706 - 4-Aminoquinoléines8-Aminoquinoléines, p. ex. chloroquine, primaquine
• A61K 31/4965 - Pyrazines non condensées
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
• A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

Three-dimensional (3D) printing methods, systems and devices are described that enable high speed printing of multiple objects using two or more objective lenses and with a large field of view. One example optical system for 3D laser printing includes one or more beamsplitters that are configured to receive a collimated optical laser beam and to produce a plurality of optical beams. The optical system also includes a plurality of objective lenses, each positioned to receive one of the plurality of optical beams, and to focus the received optical beam onto a focal plane that is shared by all of the plurality of objective lenses. The focal plane coincides with a position of 3D printable material, and upon illumination of the 3D printable material by the beams received from the plurality of objective lenses, a plurality of 3D-printed objects are simultaneously generated.

Classes IPC  ?

• B23K 26/067 - Division du faisceau en faisceaux multiples, p. ex. foyers multiples
• B23K 26/08 - Dispositifs comportant un mouvement relatif entre le faisceau laser et la pièce
• B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
• B28B 1/00 - Fabrication d'objets façonnés à partir du matériau

Abrégé

Hyperspectral imaging methods, devices and systems are described that improve the hyperspectral accuracy, and reduce manufacturing costs, by using two images that enable the recovery of hyperspectral images with high fidelity. One hyperspectral imaging device includes one or more imaging lenses, one or more sensors positioned to receive light associated with an object from the one or more imaging lenses, and a spectral filter. The hyperspectral imaging device is configured to capture a first image produced without using the spectral filer and to capture a second image produced with the spectral filter. The first image and the second image have different spectral contents, and the first and the second images are processed using a trained neural network for producing hyperspectral imaging data associated with the first and second images.

Classes IPC  ?

• H04N 23/16 - Dispositions optiques associées aux capteurs, p. ex. pour diviser des faisceaux ou pour corriger la couleur
• G06T 7/00 - Analyse d'image
• H04N 23/45 - Caméras ou modules de caméras comprenant des capteurs d'images électroniquesLeur commande pour générer des signaux d'image à partir de plusieurs capteurs d'image de type différent ou fonctionnant dans des modes différents, p. ex. avec un capteur CMOS pour les images en mouvement en combinaison avec un dispositif à couplage de charge [CCD] pour les images fixes
• H04N 23/56 - Caméras ou modules de caméras comprenant des capteurs d'images électroniquesLeur commande munis de moyens d'éclairage
• H04N 23/74 - Circuits de compensation de la variation de luminosité dans la scène en influençant la luminosité de la scène à l'aide de moyens d'éclairage
• H04N 23/84 - Chaînes de traitement de la caméraLeurs composants pour le traitement de signaux de couleur

Abrégé

Example systems and methods for radio-frequency adversarial deep-learning inference for automated network coverage estimation include a generative adversarial network (GAN) based approach for synthesizing RF maps in indoor scenarios. In some examples, a semantic map is utilized—a high-level representation of the indoor environment to encode spatial relationships and attributes of objects within the environment and guide the radio frequency (RF) map generation process. A new gradient-based loss function is introduced that computes the magnitude and direction of change in RSS values from a point within the environment. Some examples incorporate this loss function along with the antenna pattern to capture signal propagation within a given indoor configuration and generate new patterns under new configuration, antenna (beam) pattern, and center frequency.

Classes IPC  ?

• H04W 48/16 - ExplorationTraitement d'informations sur les restrictions d'accès ou les accès
• G06N 3/0475 - Réseaux génératifs
• H04B 17/318 - Force du signal reçu
• H04W 24/02 - Dispositions pour optimiser l'état de fonctionnement

Abrégé

Methods and compositions for modulating, e.g., damping, contractile oscillations by targeting and/or mimicking My BP-C in heart and skeletal muscles, including therapeutics (e.g., small molecules, peptides, enzymes, antibodies, oligonucleotides, etc.) designed to directly target contractile oscillations and/or MyBP-C. The present invention also includes methods of treating cardiac arrhythmias and/or skeletal muscle tremors by modulating/damping contractile oscillations. e.g., by targeting and/or mimicking My BP-C in the appropriate muscles (e.g., heart, skeletal muscle).

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The methods described herein can be used to produce constructs that are stronger and more resilient when subjected to repeated cyclic loading. The constructs can be formed by fabricating the construct in its mid-point conformation, and then repositioning the construct in its deployment conformation. Alternatively or additionally, the constructs can be formed with additional polymeric material and/or metals added in particular locations that correspond with the pattern of principal stress distribution when the construct is in use. Alternatively or additionally, the constructs can be formed with a plurality of fibers or metal particles embedded therein, where the fibers/particles are oriented in the direction(s) of major load(s) that are applied to the construct during use. Also described are constructs formed by the methods described above. The constructs are used in devices, medical implants, plastic flaps, tubing and/or pipes, and/or the wings of an airplane that are subjected to repeated cyclic loading.

Classes IPC  ?

• B29C 70/54 - Parties constitutives, détails ou accessoiresOpérations auxiliaires
• B29C 51/12 - Façonnage par thermoformage, p. ex. façonnage de feuilles dans des moules en deux parties ou par emboutissage profondAppareils à cet effet d'objets comportant des inserts ou des renforcements
• B29C 51/42 - Chauffage ou refroidissement
• B29C 70/56 - Tensionnage des renforcements avant ou pendant le façonnage
• B29K 1/00 - Utilisation de cellulose, de cellulose modifiée ou de dérivés de cellulose, p. ex. de viscose, comme matière de moulage
• B29K 71/00 - Utilisation de polyéthers comme matière de moulage
• B29K 75/00 - Utilisation de polyurées ou de polyuréthanes comme matière de moulage

Abrégé

Exemplary materials, methods and techniques disclosed and contemplated herein generally relate to the photochemical synthesis of various deuterated 3-formyl indoles using deuterated glyoxylic acid (CDOCO2D).

Classes IPC  ?

• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique

Abrégé

An ultraviolet (UV)-curable composition. The composition includes a first precursor compound comprising more than one alkene groups and a second precursor compound including more than two thiol groups. The first precursor compound may consist of carbon, hydrogen, and optionally sulfur. The second precursor compound may consist of carbon, hydrogen, and sulfur. The composition may be used to form the polymeric material into substrates via 3D printing and UV-curing.

Classes IPC  ?

• C08F 2/48 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible
• C08F 8/34 - Introduction d'atomes de soufre ou de groupes contenant du soufre
• C08G 75/02 - Polythioéthers
• C08K 5/00 - Emploi d'ingrédients organiques
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

Modular systems tailored for vertical farming in bodies of water provide a versatile solution for crop cultivation. They encompass an undersea module and/or an above-sea module, offering versatility for independent use or seamless integration when combined. The undersea module has a modular frame and a plurality of growth components, including Growing Boards (G-Boards) and Growing Cages (G-Cages). The above-sea module features a frame, a plurality of growth components, and an enclosure for environmental control. The configuration of each of the modules enables ease of installation, maintenance, and harvesting. Combined, these modular systems offer an integrated approach to vertical farming, fostering efficiency and sustainability.

Classes IPC  ?

• A01K 61/00 - Élevage des animaux aquatiques
• A01D 44/00 - Récolte de la flore subaquatique, p. ex. récolte des algues
• A01G 31/02 - Appareils particuliers à cet effet
• A01G 31/06 - Culture hydroponique sur des étagères ou dans des conteneurs empilés
• A01G 33/00 - Culture des algues
• A01K 61/54 - Élevage des animaux aquatiques des coquillages des bivalves, p. ex. des huîtres ou des moules
• A01K 80/00 - Ramassage des huîtres, des moules, des éponges ou autres produits similaires

Abrégé

Methods, devices and systems are described that enable generation of images with enhanced resolution and/or enhance dynamic range. The described systems eliminate the need to laterally shift the system components, or in some systems, any shift all, and instead utilize multiple exposures made at different magnifications, zoom settings, and/or aperture settings to produce images with higher resolution and/or dynamic range. One example method includes acquiring a plurality of images where each image is acquired at a particular magnification factor different than other acquired images. Each of the acquired images is processed to obtain one or more parameters, functions or modified images, and then the images are combined based on the one or more parameters, functions or modified images to obtain an enhanced-resolution image having a resolution that is higher than a resolution of each of acquired images.

Classes IPC  ?

• G06T 5/50 - Amélioration ou restauration d'image utilisant plusieurs images, p. ex. moyenne ou soustraction
• G06T 5/92 - Modification de la plage dynamique d'images ou de parties d'images basée sur les propriétés globales des images

Abrégé

The present disclosure provides an unmanned vehicle system that includes: a first non-terminal cell enclosing a first plurality of terminal cells, each of the first plurality of terminal cells enclosing a respective unmanned arial vehicle (UAV); a second non-terminal cell enclosing a second plurality of terminal cells, each of the second plurality of terminal cells enclosing a respective UAV; a first non-terminal cell linkage member fixedly coupled to the first non-terminal cell; a second non-terminal cell linkage member movably coupled to the second non-terminal cell; and a non-terminal cell pivot joint to pivotally couple the first and second non-terminal cell linkage members; wherein the first and second non-terminal cells are arranged in a single plane, and first and second non-terminal cell linkage members and the non-terminal cell pivot joint provide controllable movement of the first and second non-terminal cells with respect to one another and within the single plane.

Classes IPC  ?

• B64U 10/14 - Plates-formes volantes comportant quatre axes distincts de rotors, p. ex. quadcoptères
• B64U 20/30 - Caractéristiques de construction de véhicules aériens sans pilote pour la sécurité, p. ex. avec des composants frangibles
• B64U 30/299 - Protections de rotor

Abrégé

Disclosed are systems and methods for implementing quantum-like gate operation using logical phi-bits of a quantum analogue system for achieving controllable classical entanglement. A method can include driving an array of elastically coupled acoustic waveguides using a first frequency and a second frequency different from the second frequency. A plurality of logical phi-bits can be determined based on acoustic field measurements associated with the waveguides. A tuning parameter value associated with a selected set of logical phi-bits can be determined, wherein the tuning parameter value is associated with a unitary transformation of a state of the selected set of logical phi-bits. A unitary gate operation can be implemented for the selected set of logical phi-bits by tuning an external driver coupled to a particular acoustic waveguide of the array by using the tuning parameter value to adjust one or more of the first frequency or the second frequency.

Classes IPC  ?

• H03K 19/195 - Circuits logiques, c.-à-d. ayant au moins deux entrées agissant sur une sortieCircuits d'inversion utilisant des éléments spécifiés utilisant des dispositifs supraconducteurs

Abrégé

Disclosed are systems and methods for scalable, large, multiple logical phi-bit quantum analogue system for achieving controllable classical entanglement (e.g., nonseparability). A method can include driving an array of elastically coupled acoustic waveguides by exciting at least a first acoustic waveguide of the array using a first frequency and a second acoustic waveguide of the array using a second frequency, wherein the first frequency is different from the second frequency. A plurality of acoustic fields propagating through the array of elastically coupled acoustic waveguides can be determined, each respective acoustic field generated based on the driving of the array using the first and second frequencies. A plurality of logical phi-bits can be determined based on spectrally partitioning the one or more acoustic fields, wherein each logical phi-bit of the plurality of logical phi-bits is associated with at least two independently measurable phases.

Classes IPC  ?

• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit

Abrégé

Polymeric heart valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. The polymeric leaflets are designed to possess variable thickness throughout and typically are formed having a semi-open profile to reduce stress. Methods of making and using such polymeric heart valve systems are also described.

Classes IPC  ?

• A61F 2/24 - Valvules de cœur

Abrégé

A device for generating forces or motions in accordance with sensor data. The device includes one or more compliant mechanism units and an electromagnetic actuator configured to actuate each compliant mechanism unit. By actuating a compliant mechanism unit using an electromagnetic actuator, the device can generate a force or motion in accordance with received sensor data using hardware components that are much smaller than the servo motors used in existing systems. In various embodiments, the device may actuate one or more compliant mechanism units to control the shape of a haptic meta-surface, activate and deactivate microswitches, open and close microfluidic channels, etc. In various embodiments, the device may actuate one or more compliant mechanism units in accordance with pixel values extracted from light detection and ranging (LiDAR) data, two-dimensional image data, or other sensor data.

Classes IPC  ?

• G05D 15/01 - Commande de la force ou de la contrainte mécaniqueCommande de la pression mécanique caractérisée par l'utilisation de moyens électriques
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur

Abrégé

A human 2D patient-derived organoid screening platform to study tissue patterning and kinase pathway dynamics in single cells. With the help of this system, it is discovered that waves of ERK signaling induced by apoptotic cells play a critical role in maintaining tissue patterning and homeostasis.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies

Abrégé

Artificial polymeric valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. The valve systems described can include supportive frames which have at least one non-circular cross-section with polymeric leaflets that are symmetrical or asymmetrical. The leaflets can also have variable thicknesses. Methods of making and using such artificial polymeric valve systems are also described.

Classes IPC  ?

• A61F 2/24 - Valvules de cœur

Abrégé

A multi-layer niosome nanocarrier drug composition for optimized drug delivery is described herein. The composition comprises chloroform extract of mint, Kaempferol Iodine-127 in the inner layer, and fulvic acid in the outer layer of the niosome. The method of preparing the composition is also described herein and may involve dissolving components in chloroform and incubating kaempferol-iodine-loaded niosomes in fulvic acid. The process ensures efficient drug release and enhanced therapeutic efficacy.

Classes IPC  ?

• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
• A61K 36/16 - Gynkgophyta, p. ex. Ginkgoaceae (famille du ginkgo)
• A61K 36/534 - Mentha (menthe)
• A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

Photonic quantum computation comprises generating n-qubit photonic states, the generating comprising: emitting from a two-dimensional (2D) array of photon emitters, photons that propagate in a direction substantially perpendicular to a first plane over which the 2D array of photon emitters are arranged, and generating the n-qubit photonic states based at least in part on the 2D array of photon emitters; modulating the n-qubit photonic states in a volumetric spatial light modulator (VSLM), the modulating comprising receiving at least a portion of the n-qubit photonic quantum states and generating a distribution of photonic quantum states; generating detection event signals from respective photon detectors distributed over a region that receives a portion of the distribution of photonic quantum states; and controlling at least some modulation applied by the VSLM based at least in part on detection event signals from two or more of the photon detectors.

Classes IPC  ?

• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
• B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron
• G01B 9/02 - Interféromètres
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux

Abrégé

A system and method for real-time, simultaneous, and adaptive beam steering into multiple regions of interest replaces conventional raster scanning, where only regions of interest are scanned by a laser or other optical beam. CUDA-OpenGL interoperability with a computationally time-efficient computer-generated hologram (CGH) calculation algorithm enables such beam steering by employing a phase-spatial light modulator (SLM). The real-time CGH generation and display algorithm is incorporated into the beam steering system with variable power and scan resolution, which are adaptively controlled by camera-based object recognition.

Classes IPC  ?

• G02F 1/29 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de la position ou de la direction des rayons lumineux, c.-à-d. déflexion
• G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière

Abrégé

Adenomyosis is a highly prevalent yet enigmatic disease that can be diagnosed only via histopathology among women undergoing hysterectomy, thus, leading to underdiagnosis. Unfortunately, research on adenomyosis has been limited due to a variety of challenges, and little work has been done on non-invasive diagnostics for adenomyosis. Currently, there is no FDA-approved non-invasive method for early detection of adenomyosis. By integrating immunoassays and metabolomics analyses, candidate biomarkers for the non-invasive diagnosis of adenomyosis in cervicovaginal lavages have been identified. Thus, methods for non-invasive diagnostic, screening, and early detection of adenomyosis in patients are described herein.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A nitric oxide detector includes a vessel defining a gas chamber therein; an optical resonator disposed in the gas chamber, the optical resonator having a whispering-gallery mode of resonance; an optical source arranged at least one of proximate the vessel or within the gas chamber to provide light to be coupled into the optical resonator to thereby excite the whispering-gallery mode of resonance; and an optical detector arranged at least one of proximate the vessel or within the gas chamber to receive light to be coupled out of the optical resonator to provide a detection signal.

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
• G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé

Abrégé

This disclosure relates to uses of fumaric acid, fumaric acid esters, dimethyl fumarate, monomethyl fumarate ester, salt, or derivatives thereof by pulmonary administration in the treatment, prevention, or reversal of fibrosis e.g., pulmonary fibrosis, idiopathic pulmonary fibrosis (IPF). In certain embodiments, this disclosure relates to treating a subject with fumaric acid, fumaric acid esters, dimethyl fumarate, monomethyl fumarate ester, salt, or derivatives inhibiting TGF-mediated pro-fibrotic phenotypes. In certain embodiments, the subject is a human of an advanced age.

Classes IPC  ?

• A61K 31/225 - Acides polycarboxyliques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/4418 - Pyridines non condenséesLeurs dérivés hydrogénés ayant un carbocycle lié directement à l'hétérocycle, p. ex. cyproheptadine
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

An optical architecture for enhancing phase modulation depth for a phase light modulator includes a laser light source, a 4f, 1:1 relay where a tilted mirror with a center hole is placed at the backfocal point of the first lens. A vertically polarized (VP) and collimated light is deflected by a polarized beam splitter (PBS), followed by passing through a Quarter Wave Plate (QWP) that converts linear polarization (LP) to right circular polarization (RCP). Upon interaction of the RCP light with PLM, spatial phase is modulated by 2kd(i,j). PLM reflects and modulates phase of light while changing the handness of polarization from RHP to left hand circular polarization (LCP). The 2nd interaction with QWP changes polarization of light from LCP to horizontally polarized (HP) light. The mirror M1 is placed at a half of the Talbot distance from the PLM as described later. The reflected light by M1 is a HP light, therefore it goes through the PBS and is converted to RCP by the 3rd interaction with QWP. Finally the light is modulated by the PLM with the same phase modulation profile and reflected to the direction along the incident laser beam via QWP and PBS. After the laser beam is doubly modulated, the laser beam diffracted towards direction defined by the CGH pattern displayed on PLM. The diffracted beam is reflected by the mirror placed in the 4f 1:1 collimating optics followed by a collimating optics for beam steering.

Classes IPC  ?

• G02B 26/06 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la phase de la lumière
• G02B 27/28 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour polariser

Abrégé

A composition containing 3-hydroxyanthanilic acid (3HAA) and a compound that alters iron homeostasis (an iron chelator or an iron supplement). The combination may be used as a new antibiotic drug. Combining 3HAA with iron chelation may have the dual benefit of inhibiting pathogen growth while repressing the pathological hyperinflammatory response in septic individuals. The combination may be effective at preserving food by preventing bacterial growth.

Classes IPC  ?

• A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
• A23B 2/762 - Composés organiques contenant de l'azote
• A61K 31/164 - Amides, p. ex. acides hydroxamiques d'un acide carboxylique avec un aminoalcool, p. ex. céramides
• A61K 33/26 - FerSes composés
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61P 31/04 - Agents antibactériens

Abrégé

In one aspect, the disclosure relates to small molecules useful as inhibitors of Pim and mTOR protein kinases, pharmaceutical compositions comprising the same, and methods of treating cancers associated with phosphorylation of protein Enhancer of Decapping 3 (EDC3) including, but not limited to, prostate cancer, as well as other cancers in which Pim and mTOR protein kinases are implicated, using the same. Also disclosed are combination therapies including at least one disclosed small molecule inhibitor and at least one AKT inhibitor.

Classes IPC  ?

• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
• A61K 31/4704 - 2-Quinolones, p. ex. carbostyrile
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C07D 215/227 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 2

Abrégé

The present invention provides methods and kits a) for preventing and/or treating neuroblastoma (e.g., high-risk neuroblastoma) that is linked, in part, to high levels of ODC activity and increased cellular polyamine content, b) for predicting cancer patient survival, especially cancer patients whose cancer is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and c) for selecting treatment options for such patients based on the allelic nucleotide sequence or SNP at positions +263 and/or +316 of the ODC1 gene. The invention also provides, cancer treatment methods comprising the determination of the ODC1 genotype at the +263 and/or +316 positions, as a means to guide treatment selection, which includes, in some aspects the administration of pharmaceutically effective amounts of α-difluoromethylornithine (DFMO), either as a monotherapy or in combination with one or more other drugs. In addition, the present invention provides methods for preventing and/or treating patients that have been determined to have cancer stem cells, such as patients in cancer remission that are at risk for relapse.

Classes IPC  ?

• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
• A61K 31/203 - Acides rétinoïques
• A61K 31/415 - 1,2-Diazoles
• A61K 31/616 - Acide salicyliqueSes dérivés ayant le groupe hydroxyle en position 2 estérifié, p. ex. acide salicylsulfurique par des acides carboxyliques, p. ex. acide acétylsalicylique
• A61K 31/69 - Composés du bore
• A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux
• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/34 - Hormone mélanotrope [MSH], p. ex. alpha- ou bêta-mélanotropine
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61K 49/00 - Préparations pour examen in vivo
• A61K 49/10 - Composés organiques
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 14/68 - Hormone mélanotrope [MSH]
• C07K 14/72 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des hormones

Abrégé

In accordance with a method of forming a waveguide in a polymer film disposed on a substrate, a plurality of regions on a polymer film are selectively exposed to a first dosage of radiation. The polymer film is formed from a material having a refractive index that decreases by exposure to the radiation and subsequent heating. At least one region of the polymer film that was not previously exposed to the radiation is selectively exposing to a second dosage of radiation. The second dosage of radiation is less than the first dosage of radiation. The polymer film is heated to complete curing of the polymer film.

Classes IPC  ?

• G02B 6/138 - Circuits optiques intégrés caractérisés par le procédé de fabrication en utilisant la polymérisation
• B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes

Abrégé

A high-output bubbling sprinkler device. The device may comprise an adapter configured to be fluidly coupled to a pipe such that water flowing through the pipe is directed through the adapter. The device may further comprise a nozzle fluidly coupled to the adapter, configured to accept water from the adapter. The device may further comprise a hollow dome component fluidly coupled to the nozzle, configured to accept the water from the nozzle such that the water is directed to an inner surface of the hollow dome component, and evenly distribute the water such that an area around the sprinkler device is evenly watered.

Classes IPC  ?

• A01G 25/02 - Systèmes d'arrosage placés au-dessus du sol qui utilisent des canalisations perforées ou des canalisations avec accessoires pour la distribution, p. ex. pour l'irrigation goutte à goutte
• B05B 13/02 - Moyens pour supporter l'ouvrageDisposition ou assemblage des têtes de pulvérisationAdaptation ou disposition des moyens pour entraîner des pièces
• A62C 35/68 - Détails, p. ex. de conduites ou de systèmes de soupapes
• B05B 15/658 - Aménagements de montage pour la liaison fluide de l’appareil de pulvérisation ou de ses sorties aux conduits d’écoulement l’axe de l’appareil de pulvérisation ou de sa sortie étant perpendiculaire au conduit d’écoulement

Abrégé

A framework that brings together application development, resource management, and accelerator design into a single compilation and runtime toolchain. In one example aspect, a method for enabling execution of multiple software applications on an embedded system includes receiving a first invocation of an Application Programing Interface (API) function by a first software application and a second invocation of the API function by a second software application, and determining available computing resources corresponding to the API function. The method includes selecting, based on one or more characteristics associated with the available computing resources, a first set of computing resources and a second set of computing resources. The method also includes scheduling the first invocation of the API function using the first set of computing resources and scheduling the second invocation of the API function using the second set of computing resources.

Classes IPC  ?

• G06F 8/41 - Compilation
• G06T 1/20 - Architectures de processeursConfiguration de processeurs p. ex. configuration en pipeline
• G06F 9/30 - Dispositions pour exécuter des instructions machines, p. ex. décodage d'instructions
• G06F 9/38 - Exécution simultanée d'instructions, p. ex. pipeline ou lecture en mémoire
• G06F 13/00 - Interconnexion ou transfert d'information ou d'autres signaux entre mémoires, dispositifs d'entrée/sortie ou unités de traitement
• G06F 15/78 - Architectures de calculateurs universels à programmes enregistrés comprenant une seule unité centrale

Abrégé

A framework that brings together application development, resource management, and accelerator design into a single compilation and runtime toolchain. In one example aspect, a platform for deploying a software application on an embedded system that comprises multiple types of processing elements includes a set of Application Programing Interface (API) functions; a set of program modules each comprising hardware-specific implementation of the set of API functions corresponding to one of the multiple types of processing elements; and a compiler. The compiler is configured to receive a set of instructions representing the software application, generate a binary object by compiling the set of instructions to link to at least part of the set of program modules that corresponds to one or more target types of processing elements.

Classes IPC  ?

• G06F 8/41 - Compilation
• G06T 1/20 - Architectures de processeursConfiguration de processeurs p. ex. configuration en pipeline
• G06F 9/38 - Exécution simultanée d'instructions, p. ex. pipeline ou lecture en mémoire
• G06F 13/00 - Interconnexion ou transfert d'information ou d'autres signaux entre mémoires, dispositifs d'entrée/sortie ou unités de traitement
• G06F 15/78 - Architectures de calculateurs universels à programmes enregistrés comprenant une seule unité centrale

Abrégé

Methods, devices and systems are described that enable identification of cancerous or pre-cancerous colon tissue. The described methods and systems rely on non-imaging. randomly sampled second harmonic generation (SHG) intensity measurements that are sufficient for differentiating between tumor and normal tissue. The disclosed methods and system further provide for angle-resolved SHG measurements associated with forward and backward scattered light that eliminate the need to obtain paired normal and cancer-suspicious measurements in each patient using the described techniques.

Classes IPC  ?

• A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
• A61B 1/005 - Endoscopes flexibles
• A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

Methods, devices and systems for characterizing polarization components are described. One example method includes illuminating an area of the polarization component with a uniform light beam in a particular polarization state, and receiving, at a pixelated detector, reflected or transmitted light from the polarization component in response to illuminating the area of the polarization component. Each group of pixels of the pixelated detector receives light from a corresponding spatial region of the polarization component to allow a plurality of spatial regions of the polarization component to be measured in via a single image. The method also includes obtaining Stokes parameters of the polarization component based on the received light at the pixelated detector, and determining one or more characteristics of the polarization component for each of the plurality of the spatial regions using the Stokes parameters.

Classes IPC  ?

• G01J 4/04 - Polarimètres utilisant des moyens de détection électriques
• G01J 4/02 - Polarimètres du type à champs séparésPolarimètres du type à pénombre
• G01J 11/00 - Mesure des caractéristiques d'impulsions lumineuses individuelles ou de trains d'impulsions lumineuses
• G02B 5/30 - Éléments polarisants
• G02F 1/1333 - Dispositions relatives à la structure
• F21V 9/14 - Éléments modifiant les caractéristiques spectrales, la polarisation ou l’intensité de la lumière émise, p. ex. filtres pour produire de la lumière polarisée
• G02B 1/08 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances polarisantes
• G02B 5/20 - Filtres
• G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur

Abrégé

The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) one or more of the following kinases: DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, CLK1, CLK2, CLK3, CLK4, CDK7, CDK8/19, PI3K, PDGFrA/B, mTOR, HIPKs, and/or CMGC kinases leading to inhibition of WNT signaling. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds one or more of the following kinases: DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, CLK1, CLK2, CLK3, CLK4, CDK7, CDK8/19, PI3K, PDGFrA/B, mTOR, HIPKs, and/or CMGC kinases leading to inhibition of WNT signaling, such that the one or more kinases is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of the one or more kinases. The bifunctional compounds serve as therapeutics for the treatment of Alzheimer's disease, down syndrome, diabetes, an autoimmune disease, an inflammatory disorder (e.g., airway inflammation, osteoarthritis (e.g., knee related osteoarthritis)), cancer (e.g., glioblastoma, prostate cancer, metastatic breast cancer, metastatic lung cancer, multiple myeloma, secondary metastatic tumors of the brain, colorectal cancer, acute myeloid leukemia, myelodysplastic syndrome), a viral infection (e.g., SARS-CoV-2 infection (e.g., COVID-19)), and other diseases.

Classes IPC  ?

• C07D 487/04 - Systèmes condensés en ortho
• A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61P 35/00 - Agents anticancéreux
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
• C07D 471/04 - Systèmes condensés en ortho

Abrégé

A spectral characteristic of operation of a laser source containing, within its V-cavity, a gain medium structured to include a stack of substantially spatially-periodically distributed semiconductor material, is being tuned or varied by reshaping the V-cavity due to repositioning/reorienting the outermost reflectors limiting such cavity. When laser source configured as a VECSEL includes multiple pairs of the outermost reflectors (each pair defining a corresponding constituent V-cavity having the corresponding optical resonance), these multiple V-cavities are coupled at least through the carrier distributions within the common gain medium that such cavities share. Different modes of operation of such laser source.

Classes IPC  ?

• H01S 5/183 - Lasers à émission de surface [lasers SE], p. ex. comportant à la fois des cavités horizontales et verticales comportant uniquement des cavités verticales, p. ex. lasers à émission de surface à cavité verticale [VCSEL]
• H01S 5/04 - Procédés ou appareils pour l'excitation, p. ex. pompage
• H01S 5/065 - Accrochage de modesSuppression de modesSélection de modes
• H01S 5/22 - Structure ou forme du corps semi-conducteur pour guider l'onde optique ayant une structure à nervures ou à bandes

Abrégé

The invention relates to cylindrical tunable fluidic lenses. The cylindrical optical power of the lenses may be continuously tuned within at least ±10 diopters, without inducing any significant spherical aberration, or any other significant aberrations. The lenses feature a geometry that produces minimal or no spherical defocus. These cylindrical tunable fluidic lenses could be used to induce and/or correct cylindrical optical aberrations in adaptive optical systems, particularly in ophthalmologic applications related to objective and automatic assessment of the refractive error of the eye, without the need of receiving feedback from the subjects.

Classes IPC  ?

• G02B 3/14 - Lentilles remplies d'un fluide ou à l'intérieur desquelles le vide a été fait à distance focale variable
• A61B 3/028 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure subjective, c.-à-d. appareils de d’examen nécessitant la participation active du patient pour examen d'acuité visuelleAppareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure subjective, c.-à-d. appareils de d’examen nécessitant la participation active du patient pour la détermination de la réfraction, p. ex. phoromètres
• A61B 3/04 - Montures d'essaiJeux de lentilles pour emploi dans ces montures
• G02B 3/00 - Lentilles simples ou composées
• G02B 3/06 - Lentilles simples ou composées à surfaces non sphériques à surfaces cylindriques ou en forme de tore
• G02C 7/02 - VerresSystèmes de verres

Abrégé

A method includes determining one or more surface reactions of C, O, and H containing molecules on transitional metal surfaces based on a surface reaction database; establishing a set of descriptors for each surface reaction in the one or more surface reactions based on a Bronsted-Evans-Polanyi relationship (BEP); and predicting, using a machine learning model, an activation energy of the one or more surface reactions based on set of descriptors.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
• C01B 3/32 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air
• C01B 3/38 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air par réaction d'hydrocarbures avec des agents gazéifiants avec des catalyseurs

Abrégé

Methods, systems and devices for administering green light to subjects are described. The described techniques can be used for managing cognitive deficits or memory impairments, reducing the symptoms associated with posttraumatic stress disorder (PTSD), anxiety and neurodegenerative diseases and other conditions. One example method for managing or minimizing cognitive deficits or memory impairments includes administering, for a first time period and according to a pre-arranged schedule of administrations, light with one or more wavelengths in the range between approximately 515 nm and approximately 535 nm to a retina of a subject. The method further includes administrating the light, for a second time and subsequent periods according to the pre-arranged schedule of administrations to the retina of the subject. The first, the second and the subsequent time periods occur on separate days, and the pre-arranged schedule of administrations includes administrations that span over at least one week.

Classes IPC  ?

• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux

Abrégé

Epilepsy is one of the most common neurological disorders. However, there are currently no drugs available to prevent and/or reduce the development of said disorder. Thus, compositions and methods described herein prevent and/or arrest the development of epilepsy. Specifically, angiotensin receptor blocker (ARB), such as candesartan, is described to treat epileptic patients and those at risk for developing epilepsy.

Classes IPC  ?

• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
• A61P 25/08 - AntiépileptiquesAnticonvulsivants

Abrégé

Objective lens configurations are described that can be used to implement dual-view microscopes with two fields of view (FOVs). An example dual-view microscope objective includes a rear lens group, a front lens group, and a waveguide positioned between the rear and front lens groups. The waveguide includes a reflective region that receives light from the front lens group and partially reflects the light in a lateral direction away from the rear lens group while allowing a portion of the received light to be transmitted through the waveguide toward the rear lens group. The front and rear lens groups allow viewing or imaging of a sample in a first viewing or imaging mode having a first FOV. The front lens group and the reflective region of the waveguide allow viewing or imaging of the sample in a second viewing or imaging mode having a larger FOV compared to the first FOV.

Classes IPC  ?

• G02B 21/22 - Aménagements stéréoscopiques
• A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement

Abrégé

A system and method are provided for low probability of detection (LPD) covert radar/lidar detection. A transmitter transmits a broadband light that is in a solar-radiation spectrum, and the broadband light is modulated using a constant amplitude modulation scheme such as M-ary phase shift keying (PSK), which makes the transmitted signal difficult to distinguish the signal from the background radiation. The radar return light from a target is collected and the target is detected by a cross-correlation calculation between the received light and the modulation pattern used to encode the transmitted signal. Further, in a turbulent environment, adaptive optics can be used to improve the detection probability.

Classes IPC  ?

• G01S 17/86 - Combinaisons de systèmes lidar avec des systèmes autres que lidar, radar ou sonar, p. ex. avec des goniomètres
• G01S 17/88 - Systèmes lidar, spécialement adaptés pour des applications spécifiques
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G01S 17/894 - Imagerie 3D avec mesure simultanée du temps de vol sur une matrice 2D de pixels récepteurs, p. ex. caméras à temps de vol ou lidar flash
• H04B 10/556 - Modulation numérique, p. ex. modulation par déplacement de phase différentielle [DPSK] ou modulation par déplacement de fréquence [FSK]
• G01S 17/32 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées
• G01S 17/66 - Systèmes de poursuite utilisant d'autres ondes électromagnétiques que les ondes radio
• G01S 17/87 - Combinaisons de systèmes utilisant des ondes électromagnétiques autres que les ondes radio
• H04B 10/548 - Modulation de phase ou de fréquence

Abrégé

Epilepsy is one of the most common neurological disorders. However, there are currently no drugs available to prevent and/or reduce the development of said disorder. Thus, compositions and methods described herein prevent and/or arrest the development of epilepsy. Specifically, angiotensin receptor blocker (ARB), such as candesartan, is described to treat epileptic patients and those at risk for developing epilepsy.

Classes IPC  ?

• A61K 31/4245 - Oxadiazoles
• A61K 31/4178 - 1,3-Diazoles non condensés et contenant d'autres hétérocycles, p. ex. pilocarpine, nitrofurantoïne
• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
• A61P 25/08 - AntiépileptiquesAnticonvulsivants

Abrégé

A system and method are provided for low probability to intercept (LPI) free-space optical (FSO) communications. A transmitter transmits a broadband light (e.g., but not limited to a full width half maximum of 10 nm or more) that is in a solar-radiation spectrum, and the broadband light is modulated using a modulation scheme (e.g., binary phase shift keying). The modulated light encodes a data packet that includes a header and a codeword generated using an error correction code. After propagating through an FSO channel, the receiver collects the transmitted modulated light and used one or more balanced detectors heterodyne detectors at different center wavelengths to convert the received light to respective RF signals, which are then processed to recover the information data encoded in the codeword.

Classes IPC  ?

• H04B 10/11 - Dispositions spécifiques à la transmission en espace libre, c.-à-d. dans l’air ou le vide
• H03M 13/03 - Détection d'erreurs ou correction d'erreurs transmises par redondance dans la représentation des données, c.-à-d. mots de code contenant plus de chiffres que les mots source

Abrégé

Provided herein are specially-configured apparatus for maximizing mechanical or acoustic transmission so that a biological material supported by the apparatus reliably experiences a mechanical or acoustic wave that has minimally degraded. In this manner, a biomarker may be reliably monitored and the effect of the mechanical or acoustic wave on the biological material determined. The platform is used to manipulate a cellular interaction with the mechanical or acoustic wave. Related methods of using and making are provided.

Classes IPC  ?

• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

A portable air-quality-monitoring apparatus configured to detect and measure micron- and sub-micron-sized particles (down to 100 nm in dimension) in real time. The apparatus includes a film of fluid deposited onto the coverslip that is used to collect particles before the apparatus is deployed at outdoor monitoring sites, and can be used both in the environment devoid of a conventional optical lens element and in the environment employing such optical lens element. The presence of the film increases the scattering cross-section of particles smaller than the pixel size, thereby enabling the sub-pixel and sub-diffraction-limit sized particles to be detected.

Classes IPC  ?

• G01N 15/06 - Recherche de la concentration des suspensions de particules
• G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
• G01N 21/94 - Recherche de souillures, p. ex. de poussières

Produits et services

Headwear; Clothing, namely, tops and bottoms; Clothing, namely, sweatshirts, shirts and shorts

Abrégé

High mobility group box protein 1 (HMGB1) is a nuclear protein released during cell damage and stimulates inflammatory and proliferative pathways in the surviving neighboring cells. HMGB1 contains three cysteine residues (e.g., 23/45/106) involved in the extracellular HMGB1 oligomerization and receptor binding. The peptide compositions described herein shield the aforementioned cysteine residues, which block HMGB1 from binding to DNA and, thus, reduce apoptotic signaling within a cell. Furthermore, methods of treating inflammatory disease (e.g., PAH) by administering said peptide composition are described herein.

Classes IPC  ?

• C08K 7/08 - Composés contenant de l'oxygène
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides

Abrégé

maxmaxmaxmaxmax, and display one or more subsequent waveforms compared to the target training pressure.

Classes IPC  ?

• A63B 23/18 - Appareils d'exercice spécialement adaptés à des parties déterminées du corps pour améliorer la fonction respiratoire
• A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
• A61B 5/091 - Mesure du volume des gaz inspirés ou expirés, p. ex. pour déterminer la capacité pulmonaire
• A61B 5/097 - Dispositifs pour faciliter la collecte du gaz respiré ou pour le diriger vers ou à travers des dispositions de mesure
• A61B 5/22 - ErgométrieMesure de la force musculaire ou de la force d'un coup musculaire

Abrégé

The present invention relates to compositions and methods for preventing and/or treating bacterial disease (e.g., disease caused by Neisseria sp. such as gonorrhea). In particular, the present invention provides vaccine compositions and agents targeting Neisseria host interaction genes.

Classes IPC  ?

• A61K 39/095 - Neisseria
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/04 - Agents antibactériens
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/86 - Vecteurs viraux
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A method of treating fibrosis and cancer comprising targeting circulating cells is described herein. These circulating cells may be mechanoresponsive immune cells or circulating mesenchymal cells.

Classes IPC  ?

• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61P 35/00 - Agents anticancéreux
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

Devices and electrochemical and spectroelectrochemical methods of characterizing a perovskite layer of a semiconductor device are described. One example method includes contacting the perovskite layer with a first surface of an electrolyte layer, where a second surface of the electrolyte layer is in contact with a first counter electrode. The method further includes embedding a first reference electrode in the electrolyte layer, applying a voltage to the first reference electrode, measuring a current between the first reference electrode and the first counter electrode, and characterizing the perovskite layer based on the applied voltage and the measured current between the first reference electrode the first counter electrode. Characterizing the perovskite layer includes characterizing cation defect states of the perovskite layer.

Classes IPC  ?

• G01N 27/26 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables électrochimiquesRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en utilisant l'électrolyse ou l'électrophorèse
• G01N 27/30 - Électrodes, p. ex. électrodes pour testsDemi-cellules
• H01L 21/67 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants
• G01N 27/406 - Cellules et sondes avec des électrolytes solides

Abrégé

An occlusion-capable viewing device includes an imaging lens, a collimating lens, and a virtual display module, and between the imaging lens and the collimating lens, an image inverter, and a spatial light modulator. The imaging lens projects a first inverted image of a scene on to an entrance surface of the image inverter. The image inverter rotates the first inverted image to yield a first upright image. The spatial light modulator attenuates a first image-region of the first upright image to produce a modulated optical beam. The virtual display module includes a display device and a light combiner, which combines (i) the collimated optical beam and (ii) illumination emitted by the display device to yield an occluded image.

Classes IPC  ?

• G02B 27/01 - Dispositifs d'affichage "tête haute"
• G02B 27/30 - Collimateurs

Abrégé

Methods and devices are described that rely on interference filter designs to provide a precise and granular spectral behavior by allowing emissions of circadian-active blue and green light to reach a viewer. An example wearable device includes one or more windows positioned to allow light from a light source to propagate toward a position of a wearer's eyes, and a spectral filter that includes a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to allow circadian-active spectra to reach the wearer's eyes while blocking spectral content other than the circadian-active spectra. The designed transmission and blocking characteristics include a contiguous transmission region and two contiguous blocking regions.

Classes IPC  ?

• G02C 7/10 - Filtres, p. ex. pour faciliter l'adaptation des yeux à l'obscuritéLunettes de soleil

Abrégé

Provided are devices that simulate in vivo conditions of a biological system and that are modular for reliable assembly and disassembly to improve handling of biological systems and subsequent analysis and experimentation therein. A center block having a fluidic network to support a biological material is in fluidic connection with a pair of side channels. With this platform, biological material may be supported and exposed to a plurality of well-defined fluidic characteristics and compositions.

Classes IPC  ?

• B67D 7/08 - Aménagements des dispositifs pour commander, indiquer, mesurer ou enregistrer la quantité ou le prix du liquide transféré
• C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces

Abrégé

Methods and devices are described that relate to spectral filters and associated eyewear that are specifically designed to mitigate the disruptive effects of electric lighting on the circadian clock that can cause sleep deprivation and other physiological and psychological maladies. An example wearable device for viewing a real or virtual environment includes one or more windows positioned and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-rhythm-disruptive spectra from reaching the wearer's eyes while providing viewability of the real or virtual environment by allowing light outside of the circadian-rhythm-disruptive spectra to reach the wearer's eyes.

Classes IPC  ?

• G02C 7/10 - Filtres, p. ex. pour faciliter l'adaptation des yeux à l'obscuritéLunettes de soleil
• G02B 5/28 - Filtres d'interférence

Abrégé

A temperature-corrected biochemical sensor includes an optical resonator disposed proximate a single-mode optical fiber, the optical resonator being optically coupled to the optical fiber to receive optical whispering-gallery output light; a sensor detection system arranged to receive and detect the optical whispering-gallery output light to provide sensor signals; a temperature-correcting optical system to provide a reference beam of light to be combined at least partially coherently with a return light from the resonator to provide an interference light and convert, the interference light to temperature-correction signals; a data storage device comprising temperature calibration data for at least the optical fiber and the optical resonator; and a data processing system to calculate at least one physical property of a particle in contact with the optical resonator using the sensor signals such that the calculated physical property is temperature corrected using the temperature calibration data and the temperature-correction signals.

Classes IPC  ?

• G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique

Abrégé

Provided herein are educational models that include a substrate and one or more 3D printed structures mounted or affixed thereon, where the one or more 3D printed structures resemble crystals, normal and/or abnormal cells, or casts found in a biofluid. Also provided herein are educational models that include one or more 3D printed structures contained (for example, dispersed or suspended) in a carrier, where the one or more 3D printed structures resemble crystals, normal and/or abnormal cells, or casts found in a biofluid. Also provided herein are kits having a plurality of educational models, where each of the educational model is individually identifiable, and an answer key or guide that provides an identification of each 3D printed structure contained in each of the plurality of individually identifiable educational models. The 3D printed structures can be dimensioned for viewing with the naked eye or can be dimensioned for viewing under magnification.

Classes IPC  ?

• G09B 23/26 - Modèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour l'étude des structures moléculairesModèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour la cristallographie

Abrégé

The present invention provides a sustained drug release system comprising IL-2 and anti-IL-2 incorporated into a thermosensitive hydrogel that is engineered to be in liquid form at low temperatures for delivery, but form a hydrogel at physiological body temperatures to act as a sustained release platform. The thermostable hydrogel solution slowly releases IL-2 and anti-IL-2 to provide optimal concentrations for effective treatment of autoimmune diseases.

Classes IPC  ?

• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 38/20 - Interleukines
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons

Abrégé

Disclosed is a heart rate monitoring system containing a machine learning platform containing self-learning and/or personalizable algorithms capable of detecting and filtering out artifacts in signals indicative of an individual's heart rate, such signals generated from one or more electrocardiogram sensors. The self-learning and/or personalizable algorithms are updated periodically. Accordingly, the machine learning platform improves its accuracy in detecting and/or rejecting/filtering out artifacts and/or becomes more personalized as further signals indicative of an individual's heart rate are processed. The machine learning platform performs detection and filtering out of artifacts via dimension reduction algorithms. The system further contains a first algorithm for real time measurement of heart rate variability (HRV). Also disclosed is a heart rate monitoring method that implements a heart rate monitoring system disclosed herein. The heart rate monitoring system and method can partition physiological components of HRV from other non-physiological components, particularly physical activity and/or breathing.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques

Abrégé

Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.

Classes IPC  ?

• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
• A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
• A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p. ex. indazole
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61M 16/01 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux spécialement conçus pour l'anesthésie
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

An MRI protocol employing a new flyback echo-planar imaging (EPI) pulse sequence configured to acquire flyback EPI data in which chemical-shift artifact and magnetic field inhomogeneity are inherently encoded and a novel flyback EPI reconstructive image transformation procedure resulting in generating EPI images(s) that are not only substantially free from the Nyquist artifact of the MRI process but also substantially free from the chemical-shift artifact and geometric distortion of the MRI process.

Classes IPC  ?

• G01R 33/561 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.-à-d. systèmes d'acquisition rapide, p. ex. utilisant des séquences d'impulsions écho-planar
• G01R 33/565 - Correction de distorsions d'image, p. ex. dues à des inhomogénéités de champ magnétique
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• G01R 33/485 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo basés sur l'information de déplacement chimique
• G01R 33/50 - Systèmes d'imagerie RMN basés sur la détermination des temps de relaxation

Abrégé

Polymeric venous valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. Methods of making and using such polymeric venous valve systems are also described. The polymeric venous valve systems are well-suited for use in low pressure and low shear venous environments.

Classes IPC  ?

• A61F 2/24 - Valvules de cœur
• A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents

Abrégé

Addition of a light-recombiner in the form of a diffraction grating to an advanced-volume-hologram filter system (conventionally containing only a pre-disperser diffraction grating and a volume holographic filter VHF configured as a volume Bragg grating, VBG) demonstrated recollimation and spatial overlap of light components at different wavelengths in addition to the spectral bandwidth optimization and signal-to-noise improvement. Here, the wide spectral bandwidth is ensured by the angular Bragg-matching of the pre-disperser with the VBG. The signal-to-noise improvement is obtained by the wavefront selectivity of the VBG. The cancellation of the spectral dispersion is achieved by the light-recombiner. Utilization of a light-recombiner in the form of a diffraction grating as opposed to another dispersive optic such as an optical prism additionally eliminates the potential for spatial chirp that normally reduces the usability of the conventional AVHF system in optical imaging applications.

Classes IPC  ?

• G03H 1/26 - Procédés ou appareils adaptés spécialement pour produire des hologrammes multiples ou pour en obtenir des images, p. ex. procédés pour l'holographie à plusieurs couleurs

Abrégé

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperdinyl-formamide (or similar) structure which function as adrenoreceptor antagonists, and their use as therapeutics for the treatment and/or prevention of pain and related conditions. In addition, the present invention provides compositions comprising a mixture of opioid receptor agonist compounds and such adrenoreceptor antagonists for the treatment and/or prevention of pain and related conditions.

Classes IPC  ?

• A61K 31/4468 - Pipéridines non condensées, p. ex. pipérocaïne ayant un atome d'azote lié directement en position 4, p. ex. clébopride, fentanyl
• A61K 31/4525 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
• A61K 31/4535 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle, p. ex. pizotifène
• A61K 31/485 - Dérivés du morphinane, p. ex. morphine, codéine

Abrégé

Nonsense-mediated mRNA decay, a cellular mechanism that eliminates mRNAs containing premature termination codons, underlies the loss of mutant protein caused by two independent disease-causing mutations (e.g., cardiomyopathy) in LMOD2. To counteract this, steric-blocking oligonucleotides (SBOs) were developed to obstruct the deposition of the exon junction complex, thereby preventing nonsense-mediated mRNA decay of the mutant LMOD2 transcripts and restoring mutant protein expression. This approach forms the basis for methods of treating subjects suffering from cardiomyopathy using these SBOs.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights. By plotting a topographical representation of the diffraction efficiencies resulting from such a surface profile, step heights may be optimized to direct a desired level of light power into the diffraction orders corresponding to near, intermediate, and distance vision, thereby optimizing the lens performance.

Classes IPC  ?

• G02C 7/04 - Lentilles de contact pour les yeux
• A61F 2/14 - Parties d'yeux, p. ex. cristallins ou implants de cornéeYeux artificiels
• A61F 2/16 - Lentilles intraoculaires
• G02B 5/18 - Grilles de diffraction
• G02C 7/02 - VerresSystèmes de verres
• G02C 7/06 - VerresSystèmes de verres bifocauxVerresSystèmes de verres multifocaux

Abrégé

The present disclosure relates to compounds, compositions, and methods for inhibiting Nox4 signaling. Also described are methods of treating fibrotic disorders (e.g., pulmonary fibrosis, heart fibrosis, kidney fibrosis, liver fibrosis, skin fibrosis, mediastinal fibrosis, retroperitoneal cavity fibrosis, bone marrow fibrosis, scleroderma or systemic sclerosis) and acute respiratory distress syndrome (ARDS) using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Classes IPC  ?

• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines
• A61K 31/404 - Indoles, p. ex. pindolol
• A61K 31/4045 - Indole-alkylaminesLeurs amides, p. ex. sérotonine, mélatonine
• A61K 31/33 - Composés hétérocycliques

Produits et services

Clothing, namely, tops and bottoms; Clothing, namely, sweatshirts, shirts and shorts; Headwear

Produits et services

Clothing, namely, tops and bottoms; Clothing, namely, sweatshirts, shirts and shorts; Headwear

Abrégé

Endometrial cancer (EC) is the most common gynecologic cancer in developed countries and the fourth most common cancer affecting women in the US. In contrast to other cancers, rates of EC continue to rise, and there are indications that social determinants of health and race and/or ethnicity contribute to risk. Thus, the methods described herein provide a non-invasive means of measuring protein biomarkers in the local cervicovaginal microenvironment. These novel biomarkers may be used for diagnosing and/or predicting women that are “at risk” for the development and progression of endometrial cancer (EC; e.g., EC type 1). Specifically, the methods herein may include obtaining a sample (e.g., CVL, vaginal swabs, or secretions) from a patient and producing a profile of at least five or more protein biomarkers from the collected sample.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

Systems and methods for determining information representing an amount of an indicator of a soil trait based on a machine learning engine, and systems and methods for training the machine learning engine are described. An example method includes obtaining values of a plurality of environmental factors relating to a location, and determining the information representing the amount of the indicator by inputting the values of the plurality of environmental factors into a machine learning engine. The machine learning engine is trained using sample datasets each of which includes values of at least a portion of the plurality of environmental factors of a sample site and information representing an amount of the indicator of the sample site.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/24 - Matériaux de la terre

Abrégé

Methods and systems for differentiating different phases of ice-to-water and water-to-ice transitions based on polarimetric values are described. One example method for discriminating ice from melting ice includes obtaining measured polarimetric values for a sample. The measured values are wavelength-resolved such that each of the measured values corresponds to a particular wavelength, or a particular range of wavelengths, in a long-wave infrared (LWIR) region, and the measured polarimetric values span a plurality of wavelengths, or ranges of wavelengths, within the LWIR region. The method further includes determining a plurality of wavelength-resolved degree of polarization (DoP) values based on the measured polarimetric values, comparing the plurality of wavelength-resolved DoP values to a reference set of DoP values, and distinguishing ice from melting ice based on the comparison to the reference set of DoP values.

Classes IPC  ?

• G01N 21/21 - Propriétés affectant la polarisation
• G01N 21/3554 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour la détermination de la teneur en eau
• G01N 21/3563 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de solidesPréparation des échantillons à cet effet
• G01N 21/3577 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p. ex. l'eau polluée
• G01N 21/3581 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge lointainCouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant un rayonnement térahertz
• G01N 33/18 - Eau
• G01J 4/04 - Polarimètres utilisant des moyens de détection électriques

Abrégé

Solar balloons are a simple and lightweight option for aerial exploration and meteorological data collection both terrestrially and on other planets. By using lightweight materials that absorb visual light and emit low levels of thermal radiation, solar balloons behave similarly to hot air balloons but can ascend to much higher altitudes. Unlike hot air balloons, which use an onboard heat source to raise the temperature of the internal air, solar balloons generate heat by absorbing solar radiation, providing a free source of lift and eliminating the need for carrying an extra tank of lighter-than-air gas or fuel. The solar balloons of the present invention include mechanical vents on the tops of the balloons to store and release hot air. Using these mechanical vents, the balloons can adjust altitude to enter regions of the atmosphere with different wind flows, which can lead to horizontal controllability of the platform.

Classes IPC  ?

• B64B 1/44 - Ballons adaptés pour conserver une altitude prédéterminée
• B64B 1/64 - Mécanismes de commande de la soupape du gaz

Abrégé

Methods for manipulating metabolism in astrocytes to improve astrocytic and neuronal function, as well as individual pathology hallmarks and symptoms during the development of neurodegeneration by increasing PPARa expression and activity specifically in astrocytes within the central nervous system to treat a variety of neurodegenerative conditions including but not limited to conditions involving neuronal lipid dysregulation, oxidative damage, accumulation of β-amyloid or other protein aggregates, dementia, and motor dysfunction.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• C12N 15/86 - Vecteurs viraux
• C12N 15/864 - Vecteurs parvoviraux

Abrégé

Examples systems including an apparatus for hydrogen production are disclosed, defining two or more reaction chambers for generating a redox reaction using a redox material. The reaction chambers are rotatable relative to a thermal or heat source for reciprocal reduction and oxidation reactions of each chamber. This differentiates the temperatures of each chamber to house different stages of thermochemical reactions for hydrogen production

Classes IPC  ?

• C01B 3/06 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés inorganiques comportant un hydrogène lié électropositivement, p. ex. de l'eau, des acides, des bases, de l'ammoniac, avec des agents réducteurs inorganiques
• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
• F24S 20/20 - Collecteurs de chaleur solaire pour recevoir de l’énergie solaire concentrée, p. ex. récepteurs pour centrales électriques solaires
• F24S 60/20 - Agencements pour l’emmagasinage de la chaleur collectée par les collecteurs de chaleur solaire utilisant des réactions chimiques, p. ex. thermochimiques ou isomérisation

Abrégé

Disclosed herein is a fusion peptide comprising an inactive peptide fragment of Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and a cell internalization sequence, wherein the SGK1 fragment is capable of binding and sequestering glucocorticoid-induced leucine zipper (GILZ). In some embodiments, the inactive peptide fragment of SGK1 binds and sequesters GILZ, preventing it from binding and extending the half-life of endogenous SGK1. Also disclosed herein is a method for treating a disease associated with aberrant Serum/Glucocorticoid Regulated Kinase 1 (SGK1) activity in a subject that involves administering to the subject an agent that blocks the binding of endogenous SGK1 to endogenous glucocorticoid-induced leucine zipper (GILZ).

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• A61K 38/00 - Préparations médicinales contenant des peptides
• C07K 16/40 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre des enzymes

Abrégé

An electrospray needle comprising a coating inside the needle, wherein the coating is a non-conductive and non-ionizable organic material, and in some embodiments comprising a conductive outer coating; methods of making the electrospray needle, systems that use the electrospray needle, methods of detection using the electrospray needle, and a kit that includes the electrospray needle.

Classes IPC  ?

• H01J 49/16 - Sources d'ionsCanons à ions utilisant une ionisation de surface, p. ex. émission thermo-ionique ou photo-électrique
• C03C 17/00 - Traitement de surface du verre, p. ex. du verre dévitrifié, autre que sous forme de fibres ou de filaments, par revêtement
• C03C 17/06 - Traitement de surface du verre, p. ex. du verre dévitrifié, autre que sous forme de fibres ou de filaments, par revêtement par des métaux
• C03C 17/30 - Traitement de surface du verre, p. ex. du verre dévitrifié, autre que sous forme de fibres ou de filaments, par revêtement par des matières organiques avec des composés contenant du silicium
• G01N 30/72 - Spectromètres de masse

Abrégé

An imaging probe includes a housing, an illumination fiber, a camera, a band-stop filter, and a sample collector. The housing has a distal tip. The illumination fiber spans between the distal tip and a proximal end of the housing, and terminates at the distal tip, such that light carried by the illumination fiber illuminates a target in front of the distal tip. The camera captures an image in a field of view that overlaps a field of illumination of the illumination fiber. The band-stop filter is between the distal tip and the camera. The sample collector collects a sample from the target. And each of the illumination fiber, the camera, the band-stop filter, and the sample collector is at least partially inside the housing.

Classes IPC  ?

• A61B 1/07 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement utilisant des moyens conduisant la lumière, p. ex. des fibres optiques
• A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie