Abrégé

Soybean, one of the world's most significant protein and oil crops, has been enhanced through genetic engineering and mutagenesis to introduce or enhance agronomic traits. Both transgenic modification and mutagenesis have shown considerable variation in phenotypes observed in crop species. The effects of these methods on soybean seed composition and gene expression were determined by subjecting stable transgenic soybean lines to mutagenesis, generating 100 mutagenized lines with altered GFP expression, which were subsequently analyzed for protein and oil content.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
• A01H 4/00 - Reproduction de plantes par des techniques de culture de tissus
• C07K 14/415 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de végétaux
• C12N 15/64 - Méthodes générales pour la préparation du vecteur, pour son introduction dans la cellule ou pour la sélection de l'hôte contenant le vecteur

Abrégé

This invention is in the field of medicinal chemistry and drug delivery. In particular, the invention relates to compositions comprising bioavailability (e.g., oral and local bioavailability) enhancing ionic liquid formulations and the use thereof for treating conditions or diseases in a subject.

Classes IPC  ?

• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p.ex. cholane, cholestane, ergostérol, sitostérol
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p.ex. phosphate de pyridoxal
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61K 9/107 - Emulsions
• A61P 31/10 - Antifongiques
• A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• A61P 33/00 - Agents antiparasitaires
• A61P 35/00 - Agents anticancéreux
• A61K 31/133 - Amines, p.ex. amantadine ayant des groupes hydroxyle, p.ex. sphingosine
• A61K 31/201 - Acides carboxyliques, p.ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p.ex. acides stéarique, palmitique ou arachidique ayant une ou deux doubles liaisons, p.ex. acides oléique ou linoléique
• A61K 31/505 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime

Abrégé

A method for measuring a shape of a reflector surface of a heliostat at night using a bright star at different elevation and azimuthal settings according to an embodiment of the current invention includes setting the heliostat in fixed orientation such that aberrated and overlapping star images formed are translated due to Earth's rotation in a translation direction across the heliostat array receiver; viewing images of the bright star using a fixed array of cameras placed at or near an array receiver of the heliostat, wherein each camera of the fixed array of cameras has a large aperture lens, and simultaneous exposures are made quickly enough and repeated for long enough, so that, as they translate past the cameras, the aberrated star image is fully sampled in two dimensions, and wherein every point on the reflector surface of the heliostat appears in one or more of the recorded images as being bright from reflected starlight; and processing the recorded images from the fixed array of cameras with a data processor to obtain the surface shape by integration of the surface slopes.

Classes IPC  ?

• G01B 11/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes
• F24S 50/20 - Agencements pour commander les collecteurs de chaleur solaire pour le suivi

Abrégé

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of oral bioavailability enhancing formulations of anthelmintic benzimidazole (e.g., oxfendazole) compounds. In particular, the present disclosure provides methods for treating or preventing infectious diseases with one or more oral bioavailability enhancing formulations of anthelmintic benzimidazole (e.g., oxfendazole) compounds, or pharmaceutically acceptable salts thereof, or compositions comprising the same and an additional anti-fungal agent, and pharmaceutical compositions comprising one or more oral bioavailability enhancing formulations of anthelmintic benzimidazole (e.g., oxfendazole) compounds and at least one additional anti-fungal agent.

Classes IPC  ?

• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p.ex. benzimidazoles
• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p.ex. cholane, cholestane, ergostérol, sitostérol
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61K 9/107 - Emulsions
• A61P 31/10 - Antifongiques
• A61P 33/10 - Anthelmintiques

Abrégé

Computed tomography image reconstruction uses neural field algorithms to reconstruct images for breast cancer screening and diagnosis. An Attenuation Field Network (AFN) uses x-ray liner attenuation coefficients that form the basis for CT images as a continuous function of imaging volume coordinates. The AFN uses a fully connected network trained on attenuation measurements, captured using a limited number of X-ray projections through an image volume, to learn a continuous function that maps each volumetric coordinate within the image volume to its respective attenuation coefficient. The AFN renders the entire attenuation field or synthesizes high-fidelity projections that are acquired or unacquired. The synthesized projections may be combined with existing projections to yield denser or complete projection data that may be used by other image reconstruction methods

Classes IPC  ?

• G16H 30/00 - TIC spécialement adaptées au maniement ou au traitement d’images médicales
• G06N 3/02 - Réseaux neuronaux

Abrégé

π phase jump rotation operationresult of a transformation from the target operation result of the transformation from the π phase jump rotation operationresult of the transformation from the π phase jump rotation operation.

Abrégé

4211-aldehydes in MCRs to afford products in high yield with no deuterium scrambling.

Abrégé

Exemplary materials, methods and techniques disclosed and contemplated herein generally relate to methods for synthesizing α-deuterated α-amino acids and their derivatives.

Abrégé

Methods, devices and systems are described to eliminate or reduce unwanted polarization aberrations associated with interference filters. An example method for producing a polarization aberration compensator for a thin film interference filter includes obtaining a set of Mueller matrix values based on polarization measurements of the thin film interference filter over a spectral range, and generating a metric based on a difference between a compensated Mueller matrix and an identity matrix over the spectral range. The compensated matrix represents a cumulative Mueller matrix for a combination of the thin film interference filter and the polarization aberration compensator. A configuration of the polarization aberration compensator is determined based on evaluating the metric that eliminates or reduces the difference between the compensated Mueller matrix and the identity matrix over the spectral range. Configuration parameters, including thicknesses of birefringent layers, fast-axis angles and the number of birefringent layers in the compensator are obtained.

Classes IPC  ?

• G02B 5/30 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES Éléments optiques autres que les lentilles Éléments polarisants
• G02B 5/28 - Filtres d'interférence

Abrégé

The present disclosure concerns methods and compositions for inhibiting replication of viruses within an organism in need thereof. In some cases, the methods and compositions can be applicable to aquacultured organisms. The aquacultured organisms can include, but are not limited to, crustacean organisms such as shrimp.

Classes IPC  ?

• A61K 38/46 - Hydrolases (3)
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12N 9/22 - Ribonucléases
• C12N 15/11 - Fragments d'ADN ou d'ARN; Leurs formes modifiées
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

e.g. e.g. an anion exchange resin and a cation exchange resin. The clean dialysate can be pumped into the inlet for the dialyzing machine, or into a storage tank. Optionally, following cleaning, the levels of electrolytes are measured, if needed additional electrolytes are added to the cleaned dialysate to provide the desired levels of electrolytes in the cleaned dialysate.

Classes IPC  ?

• B01D 61/24 - Dialyse
• A61M 1/16 - Systèmes de dialyse; Reins artificiels; Oxygénateurs du sang avec membranes
• A61M 1/28 - Dialyse péritonéale
• B01J 20/04 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des composés des métaux alcalins, des métaux alcalino-terreux ou du magnésium
• B01J 20/20 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone obtenu par des procédés de carbonisation
• B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques

Abrégé

Microfluidic devices, organ-on-a-chip platforms (e.g. mimicking the human prostate gland), and uses thereof are described herein. The microfluidic device includes at least two layers and a porous membrane therebetween. Each layer includes a channel, and the first channel and the second channel are aligned such that a first region of a first channel overlaps with a region of the second channel, and a second region of the first channel does not overlap a second region of the second channel. A disease model using the microfluidic devices includes (i) placing a first type of cells in the first channel and (ii) flowing a first cell culture medium through the first channel. Optionally, in step (i) a second type of cells in the second channel and in step (ii) a second cell culture medium flows through the second channel. The microfluidic devices can be used in drug screening and testing.

Abrégé

Provided herein are compositions and methods for diagnosing, prognosing, and treating neurodegenerative diseases in a male and female subject at risk of or diagnosed with a neurodegenerative disease. In particular, provided herein are customized metabolite analyses for characterizing and treating neurodegenerative diseases in specific subject groups from a sample from said subject.

Classes IPC  ?

• A61K 49/00 - Préparations pour examen in vivo
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p.ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/92 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des lipides, p.ex. le cholestérol

Abrégé

A method of regenerating a symmetrical redox flow battery includes: a first discharge process having a duration in which a capacity of the redox flow battery in a first polarity and comprising a membrane decreases from a first to a second capacity, the process comprising: flowing a catholyte through a catholyte compartment in the first polarity; flowing an anolyte through an anolyte compartment in the first polarity; wherein: the first polarity of the redox flow battery includes a membrane having a first face in fluid communication with the catholyte compartment and a second face in fluid communication with the anolyte compartment; and the first and the second faces of the membrane being opposing surfaces of the membrane; and a second discharge process comprising: reversing the polarity of the catholyte and anolyte compartments wherein: the redox flow battery in the second polarity exhibits an initial increased capacity compared to the second capacity from the first discharge process.

Classes IPC  ?

• H01M 8/18 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Éléments à combustible à régénération, p.ex. batteries à flux REDOX ou éléments à combustible secondaires
• H01M 8/0289 - Moyens pour maintenir l’électrolyte

Abrégé

A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

Classes IPC  ?

• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci

Abrégé

Improved antibodies for detection of phosphorylated RBL1, H1.5, LARP6, SUV39H1, and FAM53C have been developed. Assays using them to detect the biomarkers: P-T143 FAM53C, P-T202 LARP6, P-S988 RBL1, P-S17 H1.5, and P-S391 SUV39H1, and diagnostic and prognostic applications stemming therefrom are also provided.

Classes IPC  ?

• C07K 16/40 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre des enzymes
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p.ex. kinases (2.7)
• G01N 33/537 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec séparation du complexe immunologique de l'antigène ou de l'anticorps non liés
• G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
• A61P 35/00 - Agents anticancéreux

Abrégé

An optical beam is provided from a transmitter aperture to a receiver aperture that receives the optical beam after displacement by a path shifting component. Received initial displacement information characterizing at least one of: an initial estimate of the displacement, or an indication that the displacement is below a predetermined threshold. Received input beams each have a different spatial mode, from a set of mutually orthogonal spatial modes that include: a lowest order spatial mode, a highest order spatial mode, and one or more intermediate order spatial modes. A relative amount of each of the input beams to be included in the optical beam is determined based at least in part on: corresponding diffraction loss estimates for each of the input beams, and the initial displacement information. One of the input beams that has a largest relative amount in the optical beam is one of the intermediate order spatial modes.

Classes IPC  ?

• G01S 7/48 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
• G01S 7/481 - Caractéristiques de structure, p.ex. agencements d'éléments optiques
• H04B 10/112 - Transmission dans la ligne de visée sur une distance étendue
• H04B 10/70 - Communications quantiques photoniques

Abrégé

Acoustic wave devices, structures and methods are described that reduce or eliminate return losses due to reflections caused by impedance mismatch. The described features and benefits are achieved without increasing the footprint of the device and improve the power budget of the acoustic wave device. An example acoustic wave device includes an input transducer, an acoustic material, and an output transducer. The acoustic material includes a number of unit cells, each having a first layer and a second layer with differing materials. Impedance values associated with the input layer, the detection layer, and/or one or both of the first layer or the second layer of the unit cells are selected to allow the input acoustic wave to propagate within the acoustic material in a first direction with substantially no backscattered acoustic waves in the opposite direction.

Abrégé

Methods, devices and systems for generating shaped, synthetic light patterns based on measured optical signals are described that are subsequently processed to generate the desired synthetic fields. By combining synthetic fields with particular amplitude, phase and/or spectral values, a desired synthetic light illumination pattern can be conceived based on the measured optical signals. The synthetic fields can then be computationally propagated in time and space to understand the characteristics of the propagated light and/or characteristics of the intervening objects.

Abrégé

Entanglement is a unique quantum information processing (QIP) feature. Entanglement can be used to implement quantum sensors with improved sensitivity over classical sensors. Disclosed are systems and techniques for entanglement distribution over turbulent free-space optical (FSO) channels based on using adaptive optics. An apparatus can include a C-band tunable laser, amplifier, and periodically poled lithium niobate (PPLN) waveguide for generating entangled photon pairs. The entangled photon pairs are multiplexed with a classical laser beam and transmitted over a free-space optical (FSO) link. A reflected beam from an intermediate node, or a direct beam from a remote transmitter with line-of-sight, is received and provided to an adaptive optics (AO) system using the classical signal as a channel probe to determine a correction. The received beam is further reflected by a deformable mirror to apply the correction. The entangled photon pairs are demultiplexed from the received beam and provided to intended users.

Abrégé

Disclosed are systems and techniques for covert and/or low probability to intercept communications using thermal source-based signaling. A transmitter can generate a modulated signal by modulating a low-density parity check (LDPC)-coded modulation signal on an amplified spontaneous emission (ASE) noise source signal. The modulated signal can be amplified by one or more Erbium-Doped Fiber Amplifier (EDFA) amplification stages. A noise-masked signal can be generated by combining the modulated signal with an added noise signal from an additional EDFA, and can be transmitted to a receiver via a free-space optical (FSO) link. A receiver can apply adaptive optics (AO) corrections to the received noise-masked signal and apply a narrowband filter. The transmitted signal can be detected from the narrowband filtered signal by using a balanced detector and a local laser, wherein the balanced detector uses a beam from the local laser to perform heterodyne detection.

Abrégé

A 3D PE/PAT imaging system and probe device includes a tissue coupling interface that enables closed-loop volumetric ultrasound and photoacoustic imaging and spectroscopy that does not depend on the operator. In addition to a probe device that incorporates light and sound signals into a coaligned axis for application to a target tissue area, the imaging system includes a volumetric scanning subsystem including a motor and a housing for the motor, the motor mechanically engaged with the probe device to actuate the probe device along a linear axis associated with a surface of the target tissue area for volumetric scanning. The tissue coupling interface includes a receiver plate that can magnetically interface with a tissue coupler element positionable around the target tissue area to minimize movement of the target tissue area, allow for hands-free operation and improve reproducibility of data generated by the imaging system.

Classes IPC  ?

• A61B 8/14 - Echo-tomographie

Abrégé

Improved membranes for various devices including encapsulation devices and delivery devices are provided. Membranes of the present disclosure provide various combinations and layers of structures and features shown and described herein. In some embodiments, a spacing is provided between certain layers to enhance vascularization of the device. The present disclosure further provides devices for delivery of drugs, agent, and for housing cells.

Abrégé

Surgical training devices, kits, and associated methods are disclosed. The surgical training devices include a body shaped to correspond to an animal. The surgical training devices also include an insert for removable insertion into an opening in the body. The insert can be to be covered by a cover, which can be removably attached to the insert. An entirety or majority of the body, the insert, and the cover can be formed of materials sourced from sources other than the animal.

Classes IPC  ?

• G09B 23/34 - Modèles anatomiques avec des parties amovibles

Abrégé

Inositol monophosphatase 1 (IMPA1) controls the activity of the primary cell proliferation signaling cascades activated through the inositol-dependent phosphorylation of Akt and PKCs. Furthermore, IMPA1-mediated control of cell proliferation involves the recruitment of cytosolic IMPA1 on a plasma membrane by the receptor for advanced glycation endproducts (RAGE). Interaction between IMPA1 and RAGE redistributes inositols from the cytosolic pool to membrane microdomains and amplifies the synthesis of membrane-bound phosphatidylinositols (PtdIns) to trigger inositol-dependent cell proliferation. Thus, the peptide compositions described herein inhibit the formation of the complex between IMPA1 and RAGE (e.g., a pathogenic complex) to control over-proliferative cells.

Classes IPC  ?

• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61P 9/12 - Antihypertenseurs

Abrégé

An optical arrangement includes an optical printed circuit board (OPCB) having at least a first optical waveguide having a first end located on the OPCB. The optical arrangement also includes at least one photonic integrated circuit (PIC) mounted to the OPCB. The PIC includes a second optical waveguide. The first waveguide has a second end located on a portion of the second waveguide to optically couple light between the PIC and the first waveguide. The portion of the second waveguide on which the second end of the first waveguide is located has an inverse taper. The inverse tapered portion is defined by a plurality of segments. The segments of the inverse tapered portion each have a length and a taper rate that causes each segment to make an equal contribution to any radiation losses in the mode transformation of light being coupled between the first and second waveguides.

Classes IPC  ?

• G02B 6/122 - Elements optiques de base, p.ex. voies de guidage de la lumière
• G02B 6/02 - Fibres optiques avec revêtement
• G02B 6/12 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES - Détails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p.ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
• G02B 6/126 - OPTIQUE ÉLÉMENTS, SYSTÈMES OU APPAREILS OPTIQUES - Détails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p.ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré utilisant des effets de polarisation
• G02B 6/14 - Convertisseurs de mode

Abrégé

Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). The present invention reveals that quinacrine directly binds to G4 RNAs found in genomic RNA of the COVID-19 virus, showing antiviral activity against COVID-19 using in vitro cell culture systems. An object of the present invention is thus a new pharmaceutical composition of quinacrine for the treatment of COVID-19. Another object of the invention is a method for administering quinacrine by various routes specifically for treatment, including oral administration, sterile intravenous injection, and others.

Classes IPC  ?

• C07D 219/12 - Radicaux aminoalkylamino liés en position 9
• A61K 31/473 - Quinoléines; Isoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p.ex. acridines, phénantridines
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p.ex. rifampine, thiothixène
• A61K 31/5377 - 1,4-Oxazines, p.ex. morpholine non condensées et contenant d'autres hétérocycles, p.ex. timolol
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07D 219/10 - Atomes d'azote liés en position 9
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Abrégé

Methods and systems of preserving, treating and monitoring organs, tissues and implants are provided. In some embodiments, systems are provided that comprises a closed terminus and a substantially sealed system and wherein a parameter is detected in order to selectively control a flow of fluid to the system. Methods and system for preserving organs are provided with reduced material needs, improved energy efficiencies, and enhanced organ preservation are provided.

Abrégé

Methods and print head configurations for fabrication of complex three-dimensional (3D) structures using anisotropic materials are described. One example 3D print head includes a tubular channel configured to receive an anisotropic material, and to allow the anisotropic material to move therein, and a chamber configured to heat the anisotropic material. The 3D print head also includes one or more electrodes positioned to at least partially surround a section of the tubular channel, where the one or more electrodes are configured to receive one or more voltages to establish an electric field across the tubular channel, and the one or more voltages are selectable to allow the electric field having a magnitude and direction to be established across the tubular channel.

Abrégé

Conventional moving control surfaces on a typical tailless aircraft are replaced with sweeping Jet Actuators ("SJAs") for Active Flow Control ("AFC"). However, a large quantity of SJAs may be necessary in each array and efficacy of SJAs has only been demonstrated at low speeds (i.e., Mach 0.2 or less). In this disclosure, Supersonic Steady Jets (SSJs) are used as control surface replacements for aircraft. The SSJs are distributed on the aircraft in locations and orientations that take into consideration changing local flow conditions on the surface of the aircraft. In one example, when a single SSJ was used to control the pitch of the aircraft, the single SSJ increased the trimmed lift of the aircraft almost as well as an array of SJAs, while providing better yaw control at a small accompanying rolling moment.

Abrégé

Several novel peptides to block various signaling domains of APN are disclosed. The peptides disclosed interrupt the action of APN (aminopeptidase N peptide) for the treatment of viral (i.e. covid) infections and PAH. The interruption is specifically accomplished by binding an antagonist/inhibitor (i.e. peptide, antibody, small molecule) to the intracellular portion of the APN.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

A system including a combination of a photobioreactor fluidly coupled to a particle filtration system is provided. Also provided are methods of cultivating Coccolithophores in the system, which can be used to capture carbon dioxide in the culture medium into calcium carbonate.

Classes IPC  ?

• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

The present disclosure provides a wearable article including a 3D printed base, 3D printed antenna ground plane structure and a 3D printed a dipole antenna structure, wherein the base, ground plane structure and dipole antenna structure comprises a 3D printed mesh which is formed of a stretchable elastomeric polymer material. The wearable article also includes signal transmission and power harvesting circuitry comprising duplexing circuit to transmit and receive data and to receive wireless power from a power transmission unit.

Abrégé

Methods for treating, ameliorating and/or preventing progression of cardiomyopathy and heart failure by drugs that reduce or inhibit Factor XII and/or activated Factor XII (collectively FXII(a)), diagnosing, and/or screening for Factor Xll(a)-inhibiting/suppressing drugs for heart failure and/or cardiomyopathy by detecting biomarkers selected from a group consisting of one or more of plasma renin activity (PRA), soluble pro-renin receptor (s(P)RR) and/or coagulation Factor XI la (FXII(a)). Reduction of Factor Xll(a) levels and/or activity is effective for treating, ameliorating and/or preventing progression of cardiomyopathy and/or heart failure in the subject.

Abrégé

A polarimetric endoscope includes an insertion tube and a polarization imaging channel. The polarization imaging channel includes (i) an imaging fiber bundle having a plurality of optical fibers and being at least partially in the insertion tube, (ii) an imaging lens at a distal tube-end, of the insertion tube, that forms an image at a distal bundle-end of the imaging fiber bundle, and (iii) a polarizer array having a plurality of polarizers each aligned to a distal end of a respective one of the plurality of optical fibers and transmitting one of a plurality of polarization states. Each of the imaging fiber bundle and the first and second illumination channels is at least partially in the insertion tube.

Abrégé

Methods and devices are described that relate to eyewear that are specifically designed to allow emissions of circadian-active green light to reach the observer. An example wearable device includes one or more windows positioned to allow light from a light source to propagate toward a position of a wearer's eyes. and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number thicknesses of the layers are selected to provide designed transmission and blocking characteristics to allow circadian-active spectra to pass through while blocking spectral content other than the circadian-active spectra. The filter characteristics include one contiguous transmission region to transmit 98%-100% of a precisely-selected green region and two contiguous blocking regions that block 80-100% of the remaining spectral content.

Classes IPC  ?

• G02C 7/10 - Filtres, p.ex. pour faciliter l'adaptation des yeux à l'obscurité; Lunettes de soleil
• G02C 11/04 - Moyens d'éclairage

Abrégé

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a tetrahydroacridine (or similar) structure, an acridine (or similar) structure, a benzonaphthyridine (or similar) structure, or a tetrahydrobenzonaphthyridine (or similar) structure which function as autophagy inhibitors and/or histone deactylase inhibitors, and their use as therapeutics for the treatment of conditions characterized with aberrant autophagy activity and/or aberrant HDAC activity (e.g., cancer, pulmonary hypertension, diabetes, neurodegenerative disorders, aging, heart disease, rheumatoid arthritis, infectious discuses, conditions and symptoms caused by a viral infection (e.g., COVID-19)).

Classes IPC  ?

• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/4706 - 4-Aminoquinoléines; 8-Aminoquinoléines, p.ex. chloroquine, primaquine
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p.ex. phosphate de pyridoxal
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Abrégé

Infectious diseases pose persistent threats to the health and wellbeing of humans and animals globally. Systems and methods for multi omics-based validation of gene expression data have been developed. The methods assess disease/infection/immunity data and identify treatment regimens most likely to yield beneficial patient outcomes. The methods are implemented in a computational program for integrated, queryable pathogen/host atlas of CDC “Urgent Threat” Pathogens. Methods of treatment for disease/infection/immunity using active agents according to the described methods are also provided. In some forms, the systems and methods determine optimal treatment regimens for subjects infected with Clostridioides difficile, or Neisseria gonorrhoeae. Exemplary subjects include farm animals and humans.

Classes IPC  ?

• G16B 25/00 - TIC spécialement adaptées à l’hybridation; TIC spécialement adaptées à l’expression de gènes ou de protéines
• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues

Abrégé

Provided are methods of treating a biological system with a gas marble, including related methods of making a gas marble from an identified gaseous chemical compound from a planetary source, including a planetary atmosphere. The collected gaseous chemical compound can be activated with a liquid having an assembly of composite nanomaterials to form stable gas marbles that are, in turn, used with a treatment method. Also provided are stable marbles gases useful in applications related to biological systems, including health-related applications by medical gas therapy.

Classes IPC  ?

• A61M 16/10 - Préparation de gaz ou vapeurs à respirer
• A61M 16/12 - Préparation de gaz ou vapeurs à respirer par mélange de gaz différents

Abrégé

Methods and devices are described that relate to spectral filters and associated eyewear that are specifically designed to block emissions of circadian-active blue light to reach the observer. An example wearable device that includes one or more windows, and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction. The number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-active spectra while allowing spectral content outside of the circadian-active spectra to pass through the spectral filter. The spectral filter further includes an additional layer to effectuate a particular color such as the color pink.

Classes IPC  ?

• G02C 7/10 - Filtres, p.ex. pour faciliter l'adaptation des yeux à l'obscurité; Lunettes de soleil
• G02B 5/28 - Filtres d'interférence
• G02C 9/04 - Fixation de pièces optiques auxiliaires par ajustage ou agrafage

Abrégé

Provided herein are devices for self-testing for a plurality of biomarkers from a liquid biofluid sample. and related methods of using the devices to test for the biomarkers presence or absence. The devices comprise a specially configured vertical flow biosensor to provide a device platform that is safe and can be used at-home/in the field without need for any specialized equipment or external power sources.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes

Abrégé

Generation of a non-Gaussian quantum state uses a quantum optical frequency comb source comprising at least one nonlinear optical medium and providing spectral modes including a plurality of pairs of entangled spectral modes, each pair including: a first spectral mode centered at a first frequency, and a second spectral mode entangled with the first spectral mode and centered at a second frequency that is spaced from the first frequency at a multiple of the frequency-bin spacing. Electrically controllable optical transformation modules are connected in series with a first module receiving the spectral modes. Two or more of the modules each comprise: a spectral mode phase shifter applying respective phase shifts to different spectral modes based on at least a first electrical signal, and a spectral mode mixer coupled to the spectral mode phase shifter and coupling spectral modes centered at different frequencies based on at least a second electrical signal.

Classes IPC  ?

• G02F 1/35 - Optique non linéaire
• G06N 10/20 - Modèles d’informatique quantique, p.ex. circuits quantiques ou ordinateurs quantiques universels
• G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p.ex. codes de surface ou distillation d’état magique

Abrégé

The adaptive methodology of (purposefully, intentionally aperiodically) poling of an optical waveguide made in a nonlinear material substrate to achieve a continuous increase of overall nonlinear conversion efficiency with increase in the length of such waveguide. As a result of such poling, the variation of at least a waveguide thickness is compensated by adjusting the poling period along the waveguide to match the local momentum difference of the nonlinear process. For a second-harmonic generation, a near-ideal performance of the nonlinear energy conversion process was demonstrated even for a 21 mm long waveguide (with the SHG efficiency as high as 9415%/W and a 82.6% absolute power conversion efficiency). The adaptive poling methodology can also be applied to compensate other systematic inhomogeneity of a WG device in, for example, etching depth, diffusion depth, dose of lithographic exposure of the nonlinear material, and doping density across the nonlinear material substrate.

Classes IPC  ?

• G02F 1/355 - Optique non linéaire caractérisée par les matériaux utilisés
• G02F 1/377 - Optique non linéaire pour la génération de l'harmonique deux dans une structure de guide d'ondes optique

Abrégé

A surgical self-retaining retractor system includes a self-retaining retractor having first and second tissue engaging members that oppose one another and maintain an opening in an incision. First and second force sensors are respectively coupled to the first and second tissue engaging members such that the force sensors detect force being exerted thereon by tissue when the self-retaining retractor is maintaining an opening through the incision.

Classes IPC  ?

• A61B 17/3205 - Instruments pour l'excision

Abrégé

An optical system for modulating a light beam emitted by a laser light source. The system includes a phase light modulation device positioned to receive the laser light beam, a 4f relay optics positioned to receive light emitted from the phase light modulation device, and having a tilt mirror positioned in the light path, the tilt mirror having a center hole that permits light to pass therethrough and relay to a focusing lens, whereby a modulated and linearly polarized beam is transmitted; a quarter wave plate having a polarized beam splitter positioned to receive the modulated and linearly polarized beam; and a digital micromirror device that includes an array of micromirrors and that modulates amplitude of light in a pixelated manner by redirecting light into two directions, on- and off-directions, by electrically controlling the tilt angle of each micromirror.

Classes IPC  ?

• G02B 26/02 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander l'intensité de la lumière
• G01S 7/481 - Caractéristiques de structure, p.ex. agencements d'éléments optiques
• G02B 27/28 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour polariser

Abrégé

Methods for determining laser pulse positions for shaping an optical element may comprise: determining a stress field for at least a portion of a substrate, wherein the stress field comprises at least three components of stress, wherein the stress field comprises a plurality of stress states for the at least a portion of the substrate; determining, based at least on the stress field and a calibration model, a spot density over the at least a portion of the substrate; determining, based on the spot density, a laser spot position allocation that arranges a number of laser pulses into a minimum number of lines that achieves the spot density; and causing, based on the laser spot position allocation, output of a machine program that coordinates a rotation stage, beam shaping, a translation stage, and a laser firing parameter for surface shaping of the at least a portion of the substrate.

Classes IPC  ?

• B23K 26/50 - Travail par transmission du faisceau laser à travers ou dans la pièce à travailler
• B23K 26/0622 - Mise en forme du faisceau laser, p.ex. à l’aide de masques ou de foyers multiples par commande directe du faisceau laser par impulsions de mise en forme
• B23K 26/08 - Dispositifs comportant un mouvement relatif entre le faisceau laser et la pièce
• B23K 103/00 - Matières à braser, souder ou découper
• G01L 5/16 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques pour la mesure de plusieurs composantes de la force

Abrégé

A networked system architecture including hardware and software elements permits data transmission between underwater systems. The network architecture includes data transmission between underwater computers, instruments, robotic vehicles, human-occupied underwater habitats, and/or worn sensor devices. Data is transmitted over wired communication channels, wireless communication channels, or a combination thereof. The network is established independent of surface connectivity (e.g., a topside connection) and creates a Local Area Network (LAN) or Wide Area Network (WAN) specific to an underwater environment. A system administrator, such as a diver, operates an underwater and waterproof computer to control and operate an underwater and waterproof device (e.g., a robotic vehicle) over the LAN/WAN. The underwater device may be a remotely operated vehicle (ROV), an autonomous underwater vehicle (AUV), a drifting sensor, a moored sensor, or the like.

Classes IPC  ?

• G05B 19/4155 - Commande numérique (CN), c.à d. machines fonctionnant automatiquement, en particulier machines-outils, p.ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'u caractérisée par le déroulement du programme, c.à d. le déroulement d'un programme de pièce ou le déroulement d'une fonction machine, p.ex. choix d'un programme

Abrégé

A large balloon reflector, capable of launching and support itself at high altitudes, with a feed system capable of steering the beam quickly enough to perform target tracking of fast-moving terrestrial, stratospheric, or orbiting objects. The large balloon reflector antenna forms a suborbital antenna system that is suitable for operation from radio to infrared wavelengths and can be used, for example, for remote sensing of objects on the ground, in the atmosphere, or in space.

Classes IPC  ?

• H01Q 1/08 - Moyens pour replier tout ou partie des antennes
• B64U 10/60 - Aéronefs captifs
• B64U 101/00 - Véhicules aériens sans pilote spécialement adaptés à des utilisations ou à des applications spécifiques
• G01C 21/16 - Navigation; Instruments de navigation non prévus dans les groupes en utilisant des mesures de la vitesse ou de l'accélération exécutées à bord de l'objet navigant; Navigation à l'estime en intégrant l'accélération ou la vitesse, c. à d. navigation par inertie
• H01Q 15/16 - Surfaces réfléchissantes; Structures équivalentes courbes suivant deux dimensions, p.ex. paraboloïdales

Abrégé

Provided herein are synthetic RNAs comprising a piRNA sequence and a target sequence for a gene of interest. The synthetic RNAs find use in methods of gene editing, in particular in methods of silencing expression of the gene of interest.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens

Abrégé

The present invention features inhibitors of the eIF4A enzyme. These inhibitors have a novel mechanism for inhibiting the eIF4A enzyme by occupying a binding pocket within the eIF4A RNA-binding groove, thereby perturbing RNA binding, blocking ATP hydrolysis, and, consequently, inhibiting RNA helicase activity. Thus, the compounds of the present invention are RNA-competitive, ATP-uncompetitive elF4A inhibitors that directly bind elF4A and inhibit the protein.

Classes IPC  ?

• C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles

Abrégé

This invention is in the field of medicinal chemistry. In particular, the invention relates to compositions comprising phenyllactic acid, and related methods for treating, preventing, and/or ameliorating symptoms and/or conditions characterized with microbiome dysbiosis (e.g., sexually transmitted infections, urinary tract infections, bacterial vaginosis).

Abrégé

Methods and compositions related to mu/delta opioid receptor heterodimer (MDOR) antagonists, including novel compositions and modifications thereof and thereto. These novel methods and compositions may enhance the beneficial effects of MDOR antagonists as compared to MDOR antagonists that are formulated differently or that are unmodified. These compositions and methods may be used (including when used concomitantly with opioid agonist-based therapy) to: enhance the antinociceptive and/or analgesic effects of opioid therapy, to reduce the side effects and/or adverse effects of opioid therapy, and/or to treat opioid dependence.

Classes IPC  ?

• C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p.ex. poudres
• A61K 9/16 - Agglomérés; Granulés; Microbilles
• A61K 31/724 - Cyclodextrines
• A61P 25/30 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance

Abrégé

Methods are disclosed for leaching metal-containing materials, such as those contained in the cathode of spent lithium-ion batteries, using a leach solution of an amino acid and a reducing agent. The metal-containing material is treated with the leach solution to recover at least one metal. For example, when the metal-containing material is lithium cobalt (III) oxide (LiCoO2), leaching with the leach solution of the present invention enables the recovery of the lithium and/or cobalt metal.

Classes IPC  ?

• C22B 7/00 - Mise en œuvre de matériaux autres que des minerais, p.ex. des rognures, pour produire des métaux non ferreux ou leurs composés
• C22B 3/00 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés
• C22B 3/04 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation
• C22B 3/44 - Traitement ou purification de solutions, p.ex. de solutions obtenues par lixiviation par des procédés chimiques
• C22B 26/12 - Obtention du lithium
• C22B 47/00 - Obtention du manganèse
• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés

Abrégé

Glycopeptides comprising a peptide that is covalently linked to one or more saccharides. The glycopeptides of the invention have a significantly reduced VPAC2 receptor agonist activity compared to a native PACAP1-27 or PACAP1-38 while maintaining a good PAC1 and/or VPAC1 receptor agonist activity. In particular, the peptide portion of the glycopeptides of the invention has from about 20 to about 25 amino acid residues, and the saccharide moiety portion of the glycopeptides of the present invention comprises from 1 to about 8 carbohydrates. The present invention also discloses methods for using the glycopeptides of the invention in treating various neurodegenerative diseases.

Classes IPC  ?

• C07K 14/00 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique

Abrégé

Described herein are assays capable of detecting one or more shrimp or fish pathogens. Also described herein are kits configured for detecting one or more shrimp or fish pathogens. In some embodiments, the assays and kits are configured as a point of care test for one or more shrimp or fish pathogens.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques
• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries

Abrégé

In accordance with a method for transferring an image over an angularly bandlimited optical data channel, a plurality of sub-images that together make up an original image are defined. The sub-images are to be transferred over the optical data channel. Each of the sub-images have a field-of-view (FOV) less than a FOV of the original image and is able to be transferred through the data channel. The sub-images are generated from the original image such that the sub-images are able to be transferred into the data channel using (i) time multiplexing, (ii) wavelength and/or polarization multiplexing and (iii) diffractive order multiplexing such that the sub-images are spatially superimposed while traversing the data channel. The spatially superimposed sub-images are transferred into the data channel. The spatially superimposed sub-images are outcoupled from the optical data channel and then spatially expanded to reconstruct the original image using a wavelength and/or polarization demultiplexing device.

Classes IPC  ?

• G02B 27/01 - Dispositifs d'affichage "tête haute"
• H04N 19/119 - Aspects de subdivision adaptative, p.ex. subdivision d’une image en blocs de codage rectangulaires ou non
• H04N 19/172 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’unité de codage, c. à d. la partie structurelle ou sémantique du signal vidéo étant l’objet ou le sujet du codage adaptatif l’unité étant une zone de l'image, p.ex. un objet la zone étant une image, une trame ou un champ
• H04N 21/236 - Assemblage d'un flux multiplexé, p.ex. flux de transport, en combinant un flux vidéo avec d'autres contenus ou données additionnelles, p.ex. insertion d'une adresse universelle [URL] dans un flux vidéo, multiplexage de données de logiciel dans un flu; Remultiplexage de flux multiplexés; Insertion de bits de remplissage dans le flux multiplexé, p.ex. pour obtenir un débit constant; Assemblage d'un flux élémentaire mis en paquets

Abrégé

Methods and devices are described that relate to spectral filters and associated eyewear that are specifically designed to block emissions of circadian-active blue light to reach the observer. An example wearable device includes one or more windows positioned to allow light from a light source to propagate toward a position of a wearer's eyes, and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows. The spectral filter includes a multi-layer stack of dielectric material. The number and thicknesses of the layers are selected to provide designed transmission and blocking characteristics. The designed characteristics include a contiguous blocking region that blocks 98-100% of the circadian-active spectra and two contiguous transmission regions that transmit 80%-100% of the spectral content outside of the circadian-active spectra.

Classes IPC  ?

• G02C 7/10 - Filtres, p.ex. pour faciliter l'adaptation des yeux à l'obscurité; Lunettes de soleil

Abrégé

A hybrid cementitious material is disclosed which can be used for roof support in underground mines, and includes a first mixture and a second mixture. The first mixture can include a precursor, a superplasticizer and water, the precursor including fly ash, cement kiln dust, and/or ordinary Portland cement; the second mixture can include water, sodium hydroxide, sodium silicate and a biopolymer. The first mixture and second mixture can have sufficiently low viscosity to be pumpable over long distances such that upon arrival at a desired location, the first and second mixtures can be combined to form the cementitious material. The cementitious material when cured combines advantageous properties including: high peak and residual compressive strength, and good stability when exposed to air. Example methods are also provided for preparing the hybrid cementitious material.

Classes IPC  ?

• C04B 12/04 - Ciments à base de silicates de métaux alcalins ou d'ammonium
• C04B 18/08 - Cendres volantes
• C04B 28/04 - Ciments Portland
• C04B 28/18 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p.ex. contenant des ciments de polycarboxylates contenant des mélanges du type chaux et silice
• C04B 7/13 - Leurs mélanges avec des matières inorganiques cimentaires, p.ex. ciments Portland
• C04B 7/153 - Leurs mélanges avec d'autres matières inorganiques cimentaires ou avec d'autres activateurs
• C04B 14/04 - Matières riches en silice; Silicates

Abrégé

Provided herein are stretch devices and related methods for controlled three-dimensional stretching of scaffolds supported on a stretchable substrate. A stretchable substrate is capable of receiving the three-dimensional scaffold, and a stretchable substrate holder is configured to connect to the stretchable substrate. An actuator is connected to the stretchable substrate holder to exert a cyclic stretch on the stretchable substrate and periodically stretch the three-dimensional scaffold connected to the stretchable substrate. A sample holder is configured to immerse the three-dimensional scaffold in a tissue culture media.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p.ex. magnétisme, ondes sonores

Abrégé

Irregular circadian rhythm sleep disorder has been known to occur in individuals with conditions such as Alzheimer's disease and developmental disabilities but has not been described in patients with gut barrier dysfunction. Although there are animal studies demonstrating the circadian entrainment of murine peripheral tissues by oral administration of short-chain fatty acids (SCFA) that are traditionally produced by "good" bacteria within the gut microbiome, there have not been any reports of modification of circadian rhythms of the entire animal ("central circadian rhythm"). Surprisingly, the Inventors showed that a patient with leaky gut syndrome and irregular circadian rhythm sleep disorder (also termed "irregular sleep-wake sleep disorder") had an improved central circadian rhythm following oral short-chain fatty acids (SCFA) supplementation. The patient reported better consolidated sleep while a delayed sleep phase phenotype remained. The favorable effect of SCFA on circadian rhythms is a novel finding described herein.

Classes IPC  ?

• A61K 31/19 - Acides carboxyliques, p.ex. acide valproïque
• A23L 33/135 - Bactéries ou leurs dérivés, p.ex. probiotiques
• A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 25/20 - Hypnotiques; Sédatifs

Abrégé

Methods, devices and systems are described that enable monitoring the diffraction efficiency of holographic material in real-time while they are being formed. One example method includes directing a reference beam and an object beam toward a holographic material for formation of a diffraction grating and blocking one of the beams for at least a portion of time during which the diffraction grating is being formed. The method further includes, upon blockage of one of the beams, based on power level measurements, determining whether or not a first diffraction efficiency is reached. If the first diffraction efficiency is reached, one of the reference or the object beams is disabled or blocked while the other beam illuminates the holographic material with a particular duty cycle. Further measurements of the diffraction efficiency are made until the final diffraction efficiency is reached.

Classes IPC  ?

• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/02 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une image; Leurs détails spécifiques - Détails

Abrégé

Blood loss during surgery is inevitable. Currently, clamps may be used to try and stop the bleeding of blood vessels. However, some blood vessels cannot be adequately clamped and therefore are left to leak blood which is then sponged off. The present invention features devices and methods for occluding vascular vessels during surgery to help prevent blood loss. Specifically, the present invention features a device (i.e., a plug) that, when inserted into the vessel lumen of the vascular vessel, prevents blood flow by exerting a radial force on the vessel. The small and versatile plugs described herein help reduce blood loss during surgery and can work on all sizes of blood vessels.

Classes IPC  ?

• A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p.ex. les vaisseaux sanguins ou le cordon ombilical

Abrégé

It has been discovered that cancer cells obtain immune cell markers by trogocytosis. Thus, methods of identifying and characterizing non-immune cells by the presence of immune cell markers thereon are provided. The method can indicate that the non-immune cells (e.g., cancer cells) have undergone trogocytosis. Such a determination can be used to design and guide cancer treatment. Thus, compositions and methods for selectively targeting and/or killing cancer cells in a subject have also been developed. In some embodiments, the compositions include an antibody, preferably a bispecific antibody, that selectively targets tumor cells with an antigen binding domain that targets an immune cell marker present on cancer cells, preferably, one that is deposited from immune cells onto tumor cell surface. In additional/alternative embodiments, the compositions and methods include administering a subject a composition for inhibiting trogocytosis. In some forms, inhibition of trogocytosis enhances the therapeutic efficacy of existing cancer therapies.

Classes IPC  ?

• C07K 16/30 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire

Abrégé

Characterizing interactions between hosts and microbes in individual animals includes exposing a population of animals in a first environment to a first microbe for a first period. The first microbe is modified to express a fluorescent protein. Fluorescent images are captured of the individual animals within the population at multiple points in time. The background of the captured fluorescent images is removed. The remaining portions of the images, considered infected portions, are analyzed. Analysis of the infected portions includes identifying the infected area, quantifying the infected area and integrating a fluorescent intensity of the infected area.

Classes IPC  ?

• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• G01N 21/64 - Fluorescence; Phosphorescence
• A61K 35/741 - Probiotiques
• A61P 31/04 - Agents antibactériens
• A61P 33/00 - Agents antiparasitaires

Abrégé

This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a N-methyl-1-(naphthalen-1-yl)ethan-1-amine (or similar) structure (e.g.: Formula I) which function as inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which function as therapeutics for the treatment of viral infection characterized with PLpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with PLpro protease activity and/or expression. This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a N-methyl-1-(naphthalen-1-yl)ethan-1-amine (or similar) structure (e.g.: Formula I) which function as inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which function as therapeutics for the treatment of viral infection characterized with PLpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with PLpro protease activity and/or expression.

Classes IPC  ?

• A61K 31/137 - Arylalkylamines, p.ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 31/166 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome de carbone d'un groupe carboxamide lié directement au cycle aromatique, p.ex. procaïnamide, procarbazine, métoclopramide, labétalol
• A61K 31/18 - Sulfamides
• A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
• A61K 31/4045 - Indole-alkylamines; Leurs amides, p.ex. sérotonine, mélatonine
• A61K 31/415 - 1,2-Diazoles
• A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p.ex. indazole
• A61K 31/417 - Imidazole-alkylamines, p.ex. histamine, phentolamine
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. indolizine, bêta-carboline
• A61K 31/4406 - Pyridines non condensées; Leurs dérivés hydrogénés substituées uniquement en position 3, p.ex. zimeldine
• A61K 31/4412 - Pyridines non condensées; Leurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
• A61K 31/47 - Quinoléines; Isoquinoléines
• A61K 31/472 - Isoquinoléines non condensées, p.ex. papavérine
• A61K 31/4965 - Pyrazines non condensées
• A61K 31/513 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p.ex. cytosine
• A61K 31/538 - 1,4-Oxazines, p.ex. morpholine condensées en ortho ou en péri avec des systèmes carbocycliques
• A61K 31/69 - Composés du bore
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

Quantum squeezed or entangled light is used to enhance the sensitivity of gyroscopes. A quantum-enhanced gyroscopic device includes a mirror resonator and a light source that provides light to probe the mirror resonator. The light includes quantum-enhanced light, such as counter-propagating quantum squeezed light or quantum entangled light. The mirror resonator may include an optical ring cavity or an optical linear cavity. The use of the quantum light enhances the Pound-Drever-Hall (PDH) lock sensitivity and suppresses the extra noise induced by Kerr nonlinearities.

Abrégé

An autonomous ultrasonographic imaging device includes an ultrasound transducer array, a processor, and memory having instructions stored thereon that, when executed by the processor, cause the autonomous ultrasonographic imaging device to capture a plurality of ultrasound images of a target area of a subject using the ultrasound transducer array, evaluate the plurality of ultrasound images using an artificial intelligence model to detect a medical condition, and display an indication of whether the medical condition was detected via a user interface. In some implementations, the autonomous ultrasonographic imaging device includes an electrotechnical movement assembly that can incrementally adjust a positioning of the ultrasound transducer array, such as between captures of the plurality of ultrasound images.

Classes IPC  ?

• G06T 7/10 - Découpage; Détection de bords
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
• A61B 6/03 - Tomographes assistés par ordinateur
• A61B 8/13 - Tomographie
• A61N 7/00 - Thérapie par ultrasons

Abrégé

Described herein are engineered nodaviral vectors, systems, and uses thereof. In some embodiments, the engineered nodaviral vectors and/or systems can be used to deliver a cargo, such as a nucleic acid cargo, to a cell or cell population, or a subject. In some embodiments, the cargo is a therapeutic or preventative.

Classes IPC  ?

• C12N 15/86 - Vecteurs viraux
• C12N 9/22 - Ribonucléases
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p.ex. oligonucléotides anti-sens

Abrégé

To avoid the limitation imposed by the optical diffraction limit when using a conventional lens-free microscopy systems on spatial resolution to approximately one-half the wavelength of used light, a proposed implementation of a lens-less imaging system utilizes a randomly nanostructured mask (preferably with features of substantially equal sizes) positioned within the limits/extent of evanescent near field of the imaged object (and, preferably, at a non-zero separation distance from the object) to encode high spatial resolution information about the object that would normally be lost due to diffraction when a conventional lens-free imaging system is used

Classes IPC  ?

• G01N 21/64 - Fluorescence; Phosphorescence
• G02B 21/00 - Microscopes

Abrégé

The present disclosure provides a system for utilization of swarms for sample return and multipoint observation using inflatables. The system includes a communications circuitry; a signaling circuitry; an inflatable structure; and a first controller, the first controller configured to: receive a message from a target spacecraft indicating a need to be captured; acknowledge the message from the target spacecraft; receive sensitive data from the target spacecraft; determine a location on the inflatable structure for capturing the target spacecraft; signal the target spacecraft to the location; and capture the target spacecraft.

Classes IPC  ?

• B64G 1/22 - Parties de véhicules spatiaux ou équipements spécialement destinés à être fixés dans ou sur ces véhicules
• B64G 4/00 - Outils spécialement adaptés au travail dans l'espace

Abrégé

Sexual dysfunction, including symptoms of vaginal dryness, irritation, and dyspareunia, is a highly prevalent condition with a substantial impact on women's physical, mental, and social well-being. However, the underlying mechanisms responsible for these symptoms are largely unknown, often resulting in inadequate treatment options for patients. Thus, methods to determine interactions between vaginal microbiota, metabolites, and immune proteins in women with or without these symptoms are described herein. The objective of these methods is to improve the understanding of the pathologic mechanisms contributing to poor sexual health.

Classes IPC  ?

• C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

In an approach to distributed computer processing networks for lunar bases and space stations, a system includes one or more sensors; a communications network; and a plurality of tiles. The tiles are configured to monitor the one or more sensors via the communications network; track a location of each computing device using the communications network; and responsive to determining any tile of the plurality of tiles has failed, transfer one or more tasks from the tile that has failed to a neighboring tile.

Classes IPC  ?

• B64G 1/12 - Satellites artificiels; Systèmes de tels satellites; Véhicules interplanétaires habités
• H04L 67/1061 - Réseaux de pairs [P2P] en utilisant des mécanismes de découverte de pairs basés sur les nœuds
• H04L 67/12 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p.ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance

Abrégé

A smart external ventricular drain system for treating brain issues in a patient without overdraining. The system comprises a catheter and a collection vessel fluidly coupled to the catheter. The collection vessel may be configured to have an adjustable vertical position. The system may further comprise a means for determining a position of the patient relative to the collection vessel and a mechanism operatively coupled to the collection vessel. The mechanism may be configured to automatically adjust the vertical position of the collection vessel in response to the position of the patient relative to the collection vessel.

Classes IPC  ?

• A61M 27/00 - Appareillage pour drainage des blessures
• A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

One of three newly diagnosed cancers is skin cancer, making skin cancer the most common malignancy worldwide. Currently, no topically applied pharmacological interventions inhibit PD-L1 to protect against skin cancer and other solar radiation-induced skin damage. Thus, described herein are topical compositions comprising a small molecule antagonist of programmed death-ligand 1 (PD-L1), e.g., BSM-202, and methods of use thereof for skin protection.

Classes IPC  ?

• A61P 35/00 - Agents anticancéreux
• A61P 37/02 - Immunomodulateurs
• C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire

Abrégé

Described herein is an anticancer combination therapy comprising a PROTAC pro-drug having a transcyclooctene (TCO) moiety and one or more compound having a tetrazine. In one embodiment, the PROTAC pro-drug is not active in the absence of the one or more compound having a tetrazine. In another embodiment, the tetrazine is administered prior to the PROTAC pro-drug. Also described herein is an anticancer combination therapy comprising a PROTAC pro-drug having a galactose, or derivative thereof, and one or more antineoplastic agent. In one embodiment, the PROTAC pro-drug is not active in the absence of the one or more antineoplastic agent. In another embodiment, the antineoplastic agent is administered prior to the PROTAC pro-drug.

Classes IPC  ?

• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
• A61K 31/4965 - Pyrazines non condensées
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p.ex. pipérazine
• A61K 31/13 - Amines, p.ex. amantadine
• A61K 31/33 - Composés hétérocycliques

Abrégé

Methods and systems are described that use deflectometric information for precise and fast eye tracking. An example method for determining a gazing direction of an eye includes determining one or more reference correspondences based on one or more images corresponding to a reflected pattern from the eye that is illuminated with a known illumination pattern. The method further includes determining one or more candidate correspondences in a virtual environment and using an optimization technique to iteratively change a location or orientation of the eye model in the virtual environment a predetermined criterion is satisfied. The gazing direction of the eye in then determined based on the orientation of the model eye when the predetermined criterion is satisfied. The described eye tracking techniques can be implemented in, for example, virtual reality (VR), augmented reality (AR), or mixed reality (MR) headsets.

Classes IPC  ?

• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
• G06F 3/03 - Dispositions pour convertir sous forme codée la position ou le déplacement d'un élément
• G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,
• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

A rectal tonometer device for quantitatively detecting and measuring a rectal tone of a patient. The device includes a main body including a cavity within and a deformable tip, including a pressure sensor, partially disposed in the cavity and extending from the main body. Deforming the tip may actuate the pressure sensor. The rectal tonometer device further includes a circuit board disposed within the cavity, communicatively coupled to the deformable tip capable of accepting a pressure signal from the pressure sensor and measuring, based on the pressure signal, the rectal tone of the patient.

Classes IPC  ?

• A61B 5/22 - Ergométrie; Mesure de la force musculaire ou de la force d'un coup musculaire
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus

Abrégé

Described herein is a recombinant Eomes protein that restores the cytotoxic activity of exhausted immune cells. This protein comprises, a nuclear localization sequence (NLS), the transcription factor associated domain of Eomesodermin (Eomes), and a protein-transduction domain (PTD). The NLS-Eomes-PTD polypeptide spontaneously internalizes into NK cells and travels to the nucleus to control the transcription of its down-stream signaling pathways. Introduction of the NLS-Eomes-PTD polypeptide into ExNK cells (i) decreases the expression of an inhibitory antigen on ExNK cells; (ii) increases cytolytic activity: (iii) enhances cytokine secretion; (iv) improves proliferation; and (v) inhibits tumor growth.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61K 35/17 - Lymphocytes; Lymphocytes B; Lymphocytes T; Cellules tueuses naturelles; Lymphocytes activés par un interféron ou une cytokine
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 35/00 - Agents anticancéreux
• C12N 5/0783 - Cellules T; Cellules NK; Progéniteurs de cellules T ou NK

Abrégé

The present invention features a liquid, solvent-free, silica precursor and two-photon 3D printing process to meet the increasing needs of high-precision glass micro-optics and address the major limitations of current three-dimensional (3D) printing optics. The printed optical elements may be fully converted to transparent inorganic glass at temperatures as low as 600° C. with shrinkages as low as 17%. The present invention includes a complete process chain, from material development, printing process, and performance evaluation of the printed glass micro-optics. 3D printing of glass micro-optics with isotropic shrinkage, micrometer resolution, low deviation peak-to-valley value (<100 nm), and low surface roughness (<6 nm) has been demonstrated. The present invention enables the rapid fabrication of complex glass micro-optics previously impossible using conventional glass optics fabrication processes.

Classes IPC  ?

• B29C 64/188 - Procédés de fabrication additive impliquant des opérations supplémentaires effectuées sur les couches ajoutées, p.ex. lissage, meulage ou contrôle d’épaisseur
• B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p.ex. de buses de jet
• B29D 11/00 - Fabrication d'éléments optiques, p.ex. lentilles ou prismes
• B29K 105/00 - Présentation, forme ou état de la matière moulée
• B29K 105/16 - Charges
• B29K 509/08 - Verre
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 40/20 - Posttraitement, p.ex. durcissement, revêtement ou polissage
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• B33Y 80/00 - Produits obtenus par fabrication additive
• C03B 19/01 - Autres méthodes de façonnage du verre par fusion progressive d'une poudre de verre sur un substrat de formage, c. à d. accrétion
• C03B 19/06 - Autres méthodes de façonnage du verre par frittage

Abrégé

A low-cost, data-fitting-free robust methodology configured to distinguish the coupling condition of an arbitrary resonance, applicable in one example to a micro-resonator of a multi-micro-resonator optical integrated circuit. The method includes registering the resonator cavity response to a rapid-phase shift of the on-resonance pump field. From the registered feature of the time-dependent transmission characteristic acquired with an optical detector, the sign of a difference between the values of intrinsic loss of the cavity and the coupling rate (γi−γc) is directly read out, thereby resulting not only in a more accurate estimation of the intrinsic loss as compared with related art, but also in facilitating practically-realizable inspection of massively integrated photonic platforms with micro-resonators.

Classes IPC  ?

• G01M 11/00 - Test des appareils optiques; Test des structures ou des ouvrages par des méthodes optiques, non prévu ailleurs

Abrégé

sii are directly mixed on the BBS or the optical hybrid to form a mixed beam, and the BBS or optical hybrid splits the mixed beam into a first beam and a second beam and outputs the first and second beams to the balanced detector. The balanced detector detects either in-phase or quadrature components. For heterodyne detection, the 2-D entanglement assisted detection scheme is provided.

Classes IPC  ?

• H04B 10/70 - Communications quantiques photoniques
• H04B 10/61 - Récepteurs cohérents
• B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p.ex. calcul quantique ou logique à un électron
• G06N 10/20 - Modèles d’informatique quantique, p.ex. circuits quantiques ou ordinateurs quantiques universels

Abrégé

The present disclosure provides a system for autonomously docking a spacecraft, the system comprising: one or more electromagnets; one or more sensors; and a controller. The controller configured to: identify a target; cause movement of the spacecraft closer to the target; determine a change in an orientation of the one or more electromagnets and the mating adapter on the target; and adjust a current in the one or more electromagnets to produce a torque, wherein the torque causes the spacecraft to align with the target.

Classes IPC  ?

• B64G 1/24 - Appareils de guidage ou de commande, p.ex. de commande d'assiette
• B64G 1/64 - Systèmes pour réunir ou séparer des véhicules spatiaux ou des parties de ceux-ci, p.ex. aménagement pour l'accostage ou l'amarrage
• B64G 1/66 - Aménagements ou adaptations d'appareils ou d'instruments, non prévus ailleurs

Abrégé

Entangled optical outputs are generated using one or more heralded entanglement sources, each comprising: first and second free-running entanglement sources, each providing a first (third) optical output comprising a quantum superposition of a pair of orthogonal optical modes, and a second (fourth) optical output comprising a quantum superposition of a pair of orthogonal optical modes; an optical module configured to perform an interferometric measurement based on optical interference between at least a portion of the first optical output and at least a portion of the third optical output, and to generate one or more detection signals based on the interferometric measurement in a series of time slots; and a trigger module configured to generate a trigger signal based on the one or more detection signals to indicate one or more time slots in which the second optical output and the fourth optical output are entangled with each other.

Classes IPC  ?

• G02F 1/35 - Optique non linéaire

Abrégé

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds and methods for activating NAMPT in a subject. The compounds described herein are useful in treating a neurological disorder, disease, or condition. In another aspect, compounds described herein are useful in treating metabolic disorders and diabetes. Formula (I) In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds and methods for activating NAMPT in a subject. The compounds described herein are useful in treating a neurological disorder, disease, or condition. In another aspect, compounds described herein are useful in treating metabolic disorders and diabetes. Formula (I)

Classes IPC  ?

• A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p.ex. azélastine, pentylènetétrazole
• C07D 487/04 - Systèmes condensés en ortho
• C07D 491/048 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à cinq chaînons
• C07D 495/04 - Systèmes condensés en ortho
• C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou

Abrégé

Maize is vital to both US agriculture and the economy. The US provides over half of the maize global market. In the US, field maize production is a $75B endeavor and comprises 95% of the total US grain production. Worldwide there is a net loss of 16 million tons of maize due to aflatoxin contamination. In the US alone, aflatoxin contamination of food/feed results in an estimated $52M-$1.68B agricultural loss every year. Aflatoxin contamination in crops, and subsequently livestock, threatens greater agricultural development, food security and human health. Elimination of aflatoxin is a critical economic and health issue in the US. The present invention features composition and methods for the degradation of aflatoxin in crops post-harvest.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 9/58 - Protéinases provenant de champignons

Abrégé

Methods, systems and devices for improving design, testing and characterization of scenes and optical systems for generating those scenes are described. The described methodology can be used, for example, to improve the generation and characterization of compute generated and virtual/augmented reality sciences by taking into consideration polarizing light-matter interactions. One example method includes an improved ray tracing technique with reduced computational needs that includes generating an incoming polarized ray and determining an exitant ray of the system using a probabilistic computation after interaction with the one or more depolarizing components. The generation of the exitant ray includes selecting a Jones matrix and the parameters of the incoming ray to compute a direction and a radiance of the exitant ray after interaction with a material that is at least partially depolarizing. These steps are repeated until a convergence criterion is reached.

Classes IPC  ?

• G02B 27/28 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour polariser

Abrégé

Methods, devices and systems are described that can be used to measure small magnetic fields, such as nano-Tesla and sub nano-Tesla magnetic fields. An example magnetometer includes a core having a photonic material that receives and maintains the propagation of polarized light. The magnetometer's cladding includes a polymer-based magneto-optic (MO) material in contact with the core which surrounds at least part of the core. The core and the cladding are configured to allow at least a portion of the polarized light to enter the cladding to interact with the polymer-based MO material in presence of an external magnetic field. Measurements of the light's polarization state after interaction with the polymer-based magneto-optic (MO) material enable a determination of a strength of the magnetic field.

Classes IPC  ?

• G01R 33/032 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs magnéto-optiques, p.ex. par effet Faraday
• G01R 1/067 - Sondes de mesure
• G01R 15/24 - Adaptations fournissant une isolation en tension ou en courant, p.ex. adaptations pour les réseaux à haute tension ou à courant fort utilisant des dispositifs modulateurs de lumière

Abrégé

Glycopeptides comprising a peptide that is covalently linked to a saccharide. The peptide portion of the glycopeptides of the invention has from about 20 to about 40 amino acid residues and at least 75% sequence identity to SEQ ID NO:5. The saccharide moiety portion of the glycopeptides of the present invention comprises from 1 to about 8 carbohydrates. The present invention also relates to using the glycopeptides of the invention in treating various neurodegenerative diseases.

Classes IPC  ?

• C07K 14/575 - Hormones
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

A palladium reversible hydrogen electrode (RHE) article is provided for measuring pH, wherein the palladium in the RHE is dynamically loaded with hydrogen atoms to reversibly form Pd-H species. A pH measurement device is provided that includes the RHE, which in some embodiments serves as a cathode, and a method is provided for measuring pH using the device. The RHE article may be miniaturized on a chip or wafer, and may be used to detect ions in water (e.g. lead ions in water running through e.g., corroding pipes).

Classes IPC  ?

• G01N 27/30 - Composants de cellules électrolytiques Électrodes, p.ex. électrodes pour tests; Demi-cellules
• G01N 27/31 - Demi-cellules avec des membranes perméables, p.ex. des membranes semi-poreuses ou à perméabilité sélective
• G01N 27/416 - Systèmes

Abrégé

A virtual slit cycloidal mass spectrometer and spectrometry methods are disclosed. The spectrometer size-selects particles, which in turn serve as a “virtual slit” for a cycloidal mass analyzer. This virtual slit provides unprecedented resolution in a system that takes up a much smaller physical footprint than was previously achievable. This spectrometer may facilitate field sampling of isotopes, such as uranium isotopes.

Classes IPC  ?

• H01J 49/32 - Spectromètres statiques utilisant une focalisation double
• H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules - Détails

Abrégé

The present disclosure relates to methods of determining and administering a treatment course of action. In particular, the present disclosure relates to compositions and methods for monitoring and treating stroke (e.g., with anti-inflammation therapy).

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur 

Abrégé

An entanglement-assisted multistatic quantum radar detection technique employs the integrated entangled source shared among multiple transmitters and performing transmit side optical phase conjugation. EA receivers are based on classical homodyne detection schemes. The EA multistatic radar detection technique is evaluated against bistatic radar EA detection scheme and various coherent states-based quantum detection schemes (the optimum quantum detector, Helstrom threshold detector, and random phase optimum quantum detector). The EA multistatic target detection probability is significantly better than that of corresponding bistatic radar EA detection techniques, coherent states-based quantum detection techniques, and the classical radar detection schemes. When both scattered signal photon channels and idler channels are noisy and lossy, the scheme significantly outperforms the EA bistatic radar scheme.

Classes IPC  ?

• H04B 10/70 - Communications quantiques photoniques
• G01C 3/08 - Utilisation de détecteurs électriques de radiations
• G01S 7/282 - Emetteurs
• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit

Abrégé

An unmanned vehicle system includes a first non-terminal cell enclosing a plurality of terminal cells, a second non-terminal cell enclosing a second plurality of terminal cells, each terminal cell enclosing a respective UAV; a first linkage member fixedly coupled to the first non-terminal cell; a second linkage member movably coupled to the second non-terminal cell; a pivot joint to pivotally couple the first and second linkage members; the first and second non-terminal cells are arranged in a single plane, and first and second linkage members and the pivot joint provide controllable movement of the first and second non-terminal cells with respect to one another and within the single plane; and controller circuitry to control each respective UAV to generate a target upward force, a target roll, and a target pitch, and a target position of the first non-terminal cell with respect to the second non-terminal cell within the single plane.

Classes IPC  ?

• B64U 10/60 - Aéronefs captifs
• B64C 37/02 - Ensembles volants formés par des aéronefs distincts
• B64U 20/00 - Caractéristiques de construction de véhicules aériens sans pilote
• G05D 1/10 - Commande de la position ou du cap dans les trois dimensions simultanément
• G05D 1/08 - Commande de l'attitude, c. à d. élimination ou réduction des effets du roulis, du tangage ou des embardées

Abrégé

Provided herein are self-collection devices for collecting and/or processing biofluids. The biofluid, such as saliva, is collected in a collection tube. A tube insert in the collection tube is configured to work with a cap having an integrated reservoir volume holding a reagent. Upon connecting the cap to the collection tube, the material in the reservoir volume is effectively introduced to or mixed with the sample in the collection tube. In this manner, there is no risk of user exposure to the reagent and no adverse impact on the ability to reliably mix reagent with sample. The device can then be shipped to a testing facility. Alternatively, a biomarker detection membrane may be used to detect more immediately, without shipping, presence or absence of a material in the sample. This provides for an almost instantaneous read-out that is incorporated into the self-collection device.

Classes IPC  ?

• A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge

Abrégé

Described herein are metal organic framework (MOF) particles and methods for detecting and quantifying radioisotopes with such MOF particles, where detecting and quantifying such radioisotopes can occur in a solvent.

Classes IPC  ?

• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation

Abrégé

Triazenes and methods of producing diazonium species from said traizenes using ultraviolet (UV) light, which provide a fast, easy, stable, scalable, and selectively-triggerable means of modifying aromatic nucleophiles, including those on protein surfaces. Thus, the present invention also includes triazenes for use as bioconjugates, e.g., for use in protein modification, for use as probes (including but not limited to detectable probes such as fluorescent probes), protein crosslinking, etc.

Classes IPC  ?

• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 49/00 - Préparations pour examen in vivo

Abrégé

Disclosed are systems and methods for scalable, large, multiple logical phi-bit quantum analogue system for achieving controllable classical entanglement (e.g., nonseparability). A method can include driving an array of elastically coupled acoustic waveguides by exciting at least a first acoustic waveguide of the array using a first frequency and a second acoustic waveguide of the array using a second frequency, wherein the first frequency is different from the second frequency. A plurality of acoustic fields propagating through the array of elastically coupled acoustic waveguides can be determined, each respective acoustic field generated based on the driving of the array using the first and second frequencies. A plurality of logical phi-bits can be determined based on spectrally partitioning the one or more acoustic fields, wherein each logical phi-bit of the plurality of logical phi-bits is associated with at least two independently measurable phases.

Classes IPC  ?

• G02F 1/125 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments acousto-optiques, p.ex. en utilisant la diffraction variable par des ondes sonores ou des vibrations mécaniques analogues dans une structure de guide d'ondes optique
• G02F 1/335 - Dispositifs de déflexion acousto-optique ayant une structure de guide d'ondes optique
• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
• G10K 11/20 - Dispositions pour réfléchir le son
• G10K 11/24 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour conduire le son à travers des corps solides, p.ex. fils métalliques
• H01P 5/04 - Dispositifs de couplage du type guide d'ondes à coefficient de couplage variable
• G01R 23/02 - Dispositions pour procéder à la mesure de fréquences, p.ex. taux de répétition d'impulsions; Dispositions pour procéder à la mesure de la période d'un courant ou d'une tension
• G06N 10/60 - Algorithmes quantiques, p.ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard
• G06F 17/14 - Transformations de Fourier, de Walsh ou transformations d'espace analogues

Abrégé

Disclosed are systems and methods for implementing quantum-like gate operation using logical phi-bits of a quantum analogue system for achieving controllable classical entanglement. A method can include driving an array of elastically coupled acoustic waveguides using a first frequency and a second frequency different from the second frequency. A plurality of logical phi-bits can be determined based on acoustic field measurements associated with the waveguides. A tuning parameter value associated with a selected set of logical phi-bits can be determined, wherein the tuning parameter value is associated with a unitary transformation of a state of the selected set of logical phi-bits. A unitary gate operation can be implemented for the selected set of logical phi-bits by tuning an external driver coupled to a particular acoustic waveguide of the array by using the tuning parameter value to adjust one or more of the first frequency or the second frequency.

Classes IPC  ?

• G02F 1/125 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p.ex. commutation, ouverture de porte ou modulation; Optique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments acousto-optiques, p.ex. en utilisant la diffraction variable par des ondes sonores ou des vibrations mécaniques analogues dans une structure de guide d'ondes optique
• G02F 1/335 - Dispositifs de déflexion acousto-optique ayant une structure de guide d'ondes optique
• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
• G10K 11/20 - Dispositions pour réfléchir le son
• G10K 11/24 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour conduire le son à travers des corps solides, p.ex. fils métalliques
• H01P 5/04 - Dispositifs de couplage du type guide d'ondes à coefficient de couplage variable
• G01R 23/02 - Dispositions pour procéder à la mesure de fréquences, p.ex. taux de répétition d'impulsions; Dispositions pour procéder à la mesure de la période d'un courant ou d'une tension
• G06N 10/60 - Algorithmes quantiques, p.ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard
• G06F 17/14 - Transformations de Fourier, de Walsh ou transformations d'espace analogues

Abrégé

Methods and systems for measuring resonance frequency, damping and mode shape of mechanical structures are described. An example method for measuring a resonance characteristic of an object includes applying a force to the object with a clock signal to cause the object to be displaced in a displacement range as a function of time. Next, the object is illuminated with a plurality of optical pulses in synchronization with the applied force such that each optical pulse illuminates the object for only a predetermined time interval and for only a portion of the displacement range of the object. A plurality of measurements is then obtained at one or more detectors based on light received from the object upon reflection of the plurality of optical pulses from the object. Finally, the resonance characteristic of the object is determined based on the plurality of measurements.

Classes IPC  ?

• G01P 15/093 - Mesure de l'accélération; Mesure de la décélération; Mesure des chocs, c. à d. d'une variation brusque de l'accélération en ayant recours aux forces d'inertie avec conversion en valeurs électriques ou magnétiques au moyen de capteurs photo-électriques
• G01B 9/02001 - Interféromètres caractérisés par la commande ou la génération des propriétés intrinsèques du rayonnement
• G01B 9/02003 - Interféromètres caractérisés par la commande ou la génération des propriétés intrinsèques du rayonnement utilisant plusieurs fréquences utilisant des fréquences de battement

Abrégé

5050 less than 10 uM. These compounds represent novel antifungals with the potential to treat cryptococcosis. Thus, compositions and methods for treating a fungal infection (e.g., cryptococcosis) are described herein.

Classes IPC  ?

• A01P 3/00 - Fongicides
• A01N 25/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'application; Substances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles
• A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques
• A61P 31/04 - Agents antibactériens