NANJING SHENGDE BIOTECHNOLOGY RESEARCH INSTITUTE CO., LTD. (China)
Inventor
Shi, Luqiu
Li, Ping
Zhang, Shasha
Li, Huashan
Abstract
Disclosed are an amino acid derivative, a preparation method therefor, and a method for synthesizing L-glufosinate ammonium using the amino acid derivative as an intermediate. The derivative is obtained from L-homoserine by means of a conventional chemical reaction. The method for preparing glufosinate ammonium, particularly L-glufosinate ammonium, using the derivative comprises the following steps: conducting a condensation reaction on the amino acid derivative (compound I) and methyl phosphite in a proper solvent to obtain compound II, and further hydrolyzing and salifying the compound II to obtain the glufosinate ammonium. The preparation method of the present invention features a high reaction speed and a high raw material conversion rate, the obtained product has a high optical rotation purity, and the raw materials used are cheap and readily available, such that the preparation method is very suitable for scale production.
C07C 311/06 - Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
NANJING SHENGDE BIOTECHNOLOGY RESEARCH INSTITUTE CO., LTD. (China)
Inventor
Shi, Luqiu
Li, Ping
Zhang, Shasha
Li, Huashan
Abstract
Disclosed in the present invention are an amino acid derivative and a preparation method therefor, and a method for using the amino acid derivative as an intermediate to synthesize L-glufosinate-ammonium. The derivative is obtained from L-homoserine by means of a conventional chemical reaction. The method for preparing glufosinate ammonium, particularly preparing L-glufosinate-ammonium by using the derivative comprises the following steps: an amino acid derivative (compound (I)) and methyl phosphite undergo a condensation reaction in a proper solvent to obtain a compound (II), and the compound (II) then undergoes hydrolysis and salification to obtain glufosinate ammonium. The preparation method disclosed by the present invention has a high reaction speed and a high raw material conversion rate, the obtained product has high optical purity, the used raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.
NANJING SHENGDE BIOTECHNOLOGY RESEARCH INSTITUTE CO., LTD. (China)
Inventor
Shi, Luqiu
Li, Ping
Zhang, Shasha
Li, Huashan
Abstract
Disclosed are an amino acid derivative, a preparation method therefor, and a method for synthesizing L-glufosinate ammonium using the amino acid derivative as an intermediate. The derivative is obtained from L-homoserine by means of a conventional chemical reaction. The method for preparing glufosinate ammonium, particularly L-glufosinate ammonium, using the derivative comprises the following steps: conducting a condensation reaction on the amino acid derivative (compound (I)) and methyl phosphite in a proper solvent to obtain compound (II), and further hydrolyzing and salifying the compound II to obtain the glufosinate ammonium. The preparation method of the present invention features a high reaction speed and a high raw material conversion rate, the obtained product has a high optical rotation purity, and the raw materials used are cheap and readily available, such that the preparation method is very suitable for scale production.
An amino acid-based scalp and hair care composition. The composition comprises the following components, by weight percentage: Long carbon chain fatty acyl amino acid-based surfactants 0.5-5%, higher aliphatic alcohols 0.5-15%, and a solvent. A scalp and hair care product containing the amino acid-based scalp and hair care composition and a preparation method thereof. The amino acid-based scalp and hair care composition uses the long carbon chain fatty acyl amino acid-based anionic surfactants as the active ingredient. When applied to the scalp and used as a hair care product, the composition can repair the hydrophobicity of the hair surface through the long carbon chain, achieve the hair care effect, and reduces irritation to the scalp.
NANJING SHENGDE INSTITUTE OF BIOTECHNOLOGY CO., LTD. (China)
Inventor
Zhang, Shasha
Shi, Luqiu
Su, Guizhen
Abstract
Provided are a fusion protein and an immobilized enzyme comprising the fusion protein. The fusion protein comprises an epoxide hydrolase enzyme active moiety and a chitin protein binding moiety. By means of utilizing the specific affinity of chitin with fusion proteins, efficient immobilization of epoxide hydrolase is achieved, and, using ethylhexyl glycidyl ether as a substrate, ethylhexylglycerin is efficiently prepared and obtained by using the immobilized enzyme. Using the immobilization method has advantages such as low costs, high enzyme immobilization efficiency, minimal enzyme activity loss, and strong specificity, fundamentally solving problems such as non-recoverability of free enzymes, poor stability, and low repeatability of conventional whole-cell immobilization methods. Problems such as deep-colored downstream separation and purification and protein residue are solved.
NANJING SHENGDE INSTITUTE OF BIOTECHNOLOGY CO., LTD. (China)
NANJING HUASHI NEW MATERIAL CO., LTD (China)
Inventor
Shi, Luqiu
Zhao, Shilan
Xue, Hongyu
Wang, Shuai
Su, Guizhen
Abstract
Provided is a Lactobacillus plantarum WSH048. The Lactobacillus plantarum WSH048 has the effects of repairing ultraviolet damage, relieving inflammation, and preventing skin photoaging. The Lactobacillus plantarum WSH048 is Lactobacillus plantarum having a strain number of WSH048, preserved in China General Microbiological Culture Collection Center on 20 August 2021, and having a preservation number of CGMCC No. 23159. The present invention further provides a screening method for the Lactobacillus plantarum WSH048 and a preparation method for a fermentation product of the Lactobacillus plantarum WSH048. The Lactobacillus plantarum WSH048 has the effects of repairing ultraviolet damage, relieving inflammation, and preventing skin photoaging, so that the problem of side effects or high price existing in solving existing problems of relieving skin inflammation can be effectively solved.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
Disclosed is an amino acid scalp and hair care composition, characterized by, in terms of weight percentage, the composition comprising the following components: 0.5-5% a long carbon chain fatty acyl amino acid surfactant, 0.5-15% a higher fatty alcohol, and the remainder being a solvent. Further disclosed are a scalp and hair care product comprising said composition, and a preparation method for the product. The long carbon chain fatty acyl amino acid anionic surfactant is used as an active ingredient in the amino acid scalp hair care composition of the present invention; when the composition is applied in a scalp and hair care product, it can repair the hydrophobicity of the hair surface by means of a long carbon chain to achieve a hair care effect, and can also reduce scalp irritation.
The present invention discloses self-thickening compositions comprising one or more N-acyl acidic amino acid and/or a salts thereof and one or more amphoteric surfactant, methods of preparation thereof, and their applications in cosmetics and personal care, home care and other fields with excellent thickening performance and easy-to-use applicability, in particular in cleansing formulations to improve performance such as foam quality and mildness.
The present invention discloses self-thickening compositions comprising one or more N-acyl acidic amino acid and/or a salts thereof and one or more amphoteric surfactant, methods of preparation thereof, and their applications in cosmetics and personal care, home care and other fields with excellent thickening performance and easy- to-use applicability, in particular in cleansing formulations to improve performance such as foam quality and mildness.
A method for preparing superfine zinc oxide powder. Crude particle zinc oxide or metal zinc is used as a raw material; an organic acid zinc salt solution is generated by means of organic acid dissolution; oxalic acid is added to generate zinc oxalate sediment; filtering is carried out to obtain zinc oxalate solid and organic acid; organic acid is used as a raw material for dissolving the crude particle zinc oxide or metal zinc in the next batch; and the zinc oxalate is calcined to obtain uniform-particle zinc oxide powder. In the method, no waste liquid or waste solids are discharged in the preparation process, and the average particle size of particles of obtained zinc oxide powder ranges from 30 nm to 200 nm in average and can be adjusted by means of the raw material proportion.
The invention provides a preparation method of N-acyl acidic amino acid or a salt thereof, comprising subjecting a fatty acyl chloride and an amino acid to an amidation reaction under an alkaline condition. The preparation method is characterized in that in the amidation reaction, water is used as a solvent, an acidic amino acid or a salt thereof is used as a main raw material and a small amount of a neutral amino acid or a salt thereof is used as an auxiliary raw material, and the method comprises the following steps: under a stirring condition, firstly adding the fatty acyl chloride dropwise into an aqueous solution of the acidic amino acid or the salt thereof; adding an alkali to adjust the pH value of the reaction solution; after a certain amount of fatty acyl chloride having been added dropwise, adding an aqueous solution of the neutral amino acid or the salt thereof, and continuing to add the fatty acyl chloride dropwise until the addition is finished and stirring to maintain the reaction. The preparation method uses the reaction of the mixed amino acids and the fatty acyl chloride under a water-phase system, so that the conversion rates of the amino acids and the acyl chloride can be remarkably increased and the amount of residual amino acids is greatly reduced. The product can be directly used as a surfactant after simple post-treatment, and thus the cost is greatly reduced.
C07C 231/02 - Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
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