Abrégé

Disclosed are an amino acid derivative, a preparation method therefor, and a method for synthesizing L-glufosinate ammonium using the amino acid derivative as an intermediate. The derivative is obtained from L-homoserine by means of a conventional chemical reaction. The method for preparing glufosinate ammonium, particularly L-glufosinate ammonium, using the derivative comprises the following steps: conducting a condensation reaction on the amino acid derivative (compound I) and methyl phosphite in a proper solvent to obtain compound II, and further hydrolyzing and salifying the compound II to obtain the glufosinate ammonium. The preparation method of the present invention features a high reaction speed and a high raw material conversion rate, the obtained product has a high optical rotation purity, and the raw materials used are cheap and readily available, such that the preparation method is very suitable for scale production.

Classes IPC  ?

• C07C 311/06 - Sulfonamides ayant des atomes de soufre de groupes sulfonamide liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé ayant les atomes d'azote des groupes sulfonamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone acycliques de radicaux hydrocarbonés substitués par des groupes carboxyle
• C07F 9/30 - Acides phosphiniques [R2=P(:O)OH]Acides thiophosphiniques

Abrégé

Disclosed in the present invention are an amino acid derivative and a preparation method therefor, and a method for using the amino acid derivative as an intermediate to synthesize L-glufosinate-ammonium. The derivative is obtained from L-homoserine by means of a conventional chemical reaction. The method for preparing glufosinate ammonium, particularly preparing L-glufosinate-ammonium by using the derivative comprises the following steps: an amino acid derivative (compound (I)) and methyl phosphite undergo a condensation reaction in a proper solvent to obtain a compound (II), and the compound (II) then undergoes hydrolysis and salification to obtain glufosinate ammonium. The preparation method disclosed by the present invention has a high reaction speed and a high raw material conversion rate, the obtained product has high optical purity, the used raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

Classes IPC  ?

• C07C 309/66 - Méthanesulfonates
• C07C 309/63 - Esters d'acides sulfoniques
• C07F 9/30 - Acides phosphiniques [R2=P(:O)OH]Acides thiophosphiniques

Abrégé

Disclosed are an amino acid derivative, a preparation method therefor, and a method for synthesizing L-glufosinate ammonium using the amino acid derivative as an intermediate. The derivative is obtained from L-homoserine by means of a conventional chemical reaction. The method for preparing glufosinate ammonium, particularly L-glufosinate ammonium, using the derivative comprises the following steps: conducting a condensation reaction on the amino acid derivative (compound (I)) and methyl phosphite in a proper solvent to obtain compound (II), and further hydrolyzing and salifying the compound II to obtain the glufosinate ammonium. The preparation method of the present invention features a high reaction speed and a high raw material conversion rate, the obtained product has a high optical rotation purity, and the raw materials used are cheap and readily available, such that the preparation method is very suitable for scale production.

Classes IPC  ?

• C07D 263/26 - Atomes d'oxygène liés en position 2 avec des hétéro-atomes ou des radicaux acyle liés directement à l'atome d'azote du cycle
• C07F 9/547 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle
• C07F 9/653 - Cycles à cinq chaînons
• C07F 9/40 - Leurs esters
• C07F 9/32 - Leurs esters
• C07F 9/53 - Oxydes des organo-phospinesSulfures des organo-phosphines
• C07K 5/08 - Tripeptides
• A62D 101/04 - Pesticides, p. ex. insecticides, herbicides, fongicides ou nématicides

Abrégé

An amino acid-based scalp and hair care composition. The composition comprises the following components, by weight percentage: Long carbon chain fatty acyl amino acid-based surfactants 0.5-5%, higher aliphatic alcohols 0.5-15%, and a solvent. A scalp and hair care product containing the amino acid-based scalp and hair care composition and a preparation method thereof. The amino acid-based scalp and hair care composition uses the long carbon chain fatty acyl amino acid-based anionic surfactants as the active ingredient. When applied to the scalp and used as a hair care product, the composition can repair the hydrophobicity of the hair surface through the long carbon chain, achieve the hair care effect, and reduces irritation to the scalp.

Classes IPC  ?

• A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
• A61K 8/34 - Alcools
• A61Q 5/00 - Préparations pour les soins des cheveux

Abrégé

Provided are a fusion protein and an immobilized enzyme comprising the fusion protein. The fusion protein comprises an epoxide hydrolase enzyme active moiety and a chitin protein binding moiety. By means of utilizing the specific affinity of chitin with fusion proteins, efficient immobilization of epoxide hydrolase is achieved, and, using ethylhexyl glycidyl ether as a substrate, ethylhexylglycerin is efficiently prepared and obtained by using the immobilized enzyme. Using the immobilization method has advantages such as low costs, high enzyme immobilization efficiency, minimal enzyme activity loss, and strong specificity, fundamentally solving problems such as non-recoverability of free enzymes, poor stability, and low repeatability of conventional whole-cell immobilization methods. Problems such as deep-colored downstream separation and purification and protein residue are solved.

Classes IPC  ?

• C12N 11/10 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique le support étant un hydrate de carbone
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12P 7/18 - Polyols
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli

Abrégé

Provided is a Lactobacillus plantarum WSH048. The Lactobacillus plantarum WSH048 has the effects of repairing ultraviolet damage, relieving inflammation, and preventing skin photoaging. The Lactobacillus plantarum WSH048 is Lactobacillus plantarum having a strain number of WSH048, preserved in China General Microbiological Culture Collection Center on 20 August 2021, and having a preservation number of CGMCC No. 23159. The present invention further provides a screening method for the Lactobacillus plantarum WSH048 and a preparation method for a fermentation product of the Lactobacillus plantarum WSH048. The Lactobacillus plantarum WSH048 has the effects of repairing ultraviolet damage, relieving inflammation, and preventing skin photoaging, so that the problem of side effects or high price existing in solving existing problems of relieving skin inflammation can be effectively solved.

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• A61K 8/99 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de micro-organismes autres que des algues ou des champignons, p. ex. à base de protozoaires ou de bactéries
• A61Q 19/00 - Préparations pour les soins de la peau
• A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
• A61K 35/745 - Bifidobactéries
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• C12R 1/25 - Lactobacillus plantarum

Abrégé

Disclosed is an amino acid scalp and hair care composition, characterized by, in terms of weight percentage, the composition comprising the following components: 0.5-5% a long carbon chain fatty acyl amino acid surfactant, 0.5-15% a higher fatty alcohol, and the remainder being a solvent. Further disclosed are a scalp and hair care product comprising said composition, and a preparation method for the product. The long carbon chain fatty acyl amino acid anionic surfactant is used as an active ingredient in the amino acid scalp hair care composition of the present invention; when the composition is applied in a scalp and hair care product, it can repair the hydrophobicity of the hair surface by means of a long carbon chain to achieve a hair care effect, and can also reduce scalp irritation.

Classes IPC  ?

• A61K 8/34 - Alcools
• A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
• A61Q 5/12 - Préparations contenant des agents de conditionnement des cheveux

Abrégé

The present invention discloses self-thickening compositions comprising one or more N-acyl acidic amino acid and/or a salts thereof and one or more amphoteric surfactant, methods of preparation thereof, and their applications in cosmetics and personal care, home care and other fields with excellent thickening performance and easy-to-use applicability, in particular in cleansing formulations to improve performance such as foam quality and mildness.

Classes IPC  ?

• A61K 8/00 - Cosmétiques ou préparations similaires pour la toilette
• A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
• A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61Q 5/02 - Préparations pour le lavage des cheveux
• A61Q 19/10 - Préparations pour le nettoyage ou le bain
• C11D 1/94 - Mélanges avec des composés anioniques, cationiques ou non ioniques
• C11D 3/33 - Acides aminocarboxyliques
• C11D 1/88 - AmpholytesComposés électriquement neutres
• C11D 3/30 - AminesAmines substituées
• C11D 3/43 - Solvants
• C11D 1/83 - Mélanges de composés non ioniques et anioniques
• C11D 17/00 - Détergents ou savons caractérisés par leur forme ou leurs propriétés physiques
• C11D 1/90 - Bétaïnes
• C11D 1/92 - Sulfobétaïnes
• C11D 1/10 - Acides aminocarboxyliquesAcides iminocarboxyliquesLeurs produits de condensation avec des acides gras

Abrégé

The present invention discloses self-thickening compositions comprising one or more N-acyl acidic amino acid and/or a salts thereof and one or more amphoteric surfactant, methods of preparation thereof, and their applications in cosmetics and personal care, home care and other fields with excellent thickening performance and easy- to-use applicability, in particular in cleansing formulations to improve performance such as foam quality and mildness.

Classes IPC  ?

• C11D 1/10 - Acides aminocarboxyliquesAcides iminocarboxyliquesLeurs produits de condensation avec des acides gras
• C11D 1/88 - AmpholytesComposés électriquement neutres
• C11D 1/90 - Bétaïnes
• C11D 1/83 - Mélanges de composés non ioniques et anioniques
• C11D 3/30 - AminesAmines substituées
• C11D 3/43 - Solvants
• A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés

Abrégé

A method for preparing superfine zinc oxide powder. Crude particle zinc oxide or metal zinc is used as a raw material; an organic acid zinc salt solution is generated by means of organic acid dissolution; oxalic acid is added to generate zinc oxalate sediment; filtering is carried out to obtain zinc oxalate solid and organic acid; organic acid is used as a raw material for dissolving the crude particle zinc oxide or metal zinc in the next batch; and the zinc oxalate is calcined to obtain uniform-particle zinc oxide powder. In the method, no waste liquid or waste solids are discharged in the preparation process, and the average particle size of particles of obtained zinc oxide powder ranges from 30 nm to 200 nm in average and can be adjusted by means of the raw material proportion.

Classes IPC  ?

• C01G 9/02 - OxydesHydroxydes
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites

Abrégé

The invention provides a preparation method of N-acyl acidic amino acid or a salt thereof, comprising subjecting a fatty acyl chloride and an amino acid to an amidation reaction under an alkaline condition. The preparation method is characterized in that in the amidation reaction, water is used as a solvent, an acidic amino acid or a salt thereof is used as a main raw material and a small amount of a neutral amino acid or a salt thereof is used as an auxiliary raw material, and the method comprises the following steps: under a stirring condition, firstly adding the fatty acyl chloride dropwise into an aqueous solution of the acidic amino acid or the salt thereof; adding an alkali to adjust the pH value of the reaction solution; after a certain amount of fatty acyl chloride having been added dropwise, adding an aqueous solution of the neutral amino acid or the salt thereof, and continuing to add the fatty acyl chloride dropwise until the addition is finished and stirring to maintain the reaction. The preparation method uses the reaction of the mixed amino acids and the fatty acyl chloride under a water-phase system, so that the conversion rates of the amino acids and the acyl chloride can be remarkably increased and the amount of residual amino acids is greatly reduced. The product can be directly used as a surfactant after simple post-treatment, and thus the cost is greatly reduced.

Classes IPC  ?

• A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
• A61Q 19/10 - Préparations pour le nettoyage ou le bain
• C07C 231/02 - Préparation d'amides d'acides carboxyliques à partir d'acides carboxyliques ou à partir de leurs esters, anhydrides ou halogénures par réaction avec de l'ammoniac ou des amines